Make your appointment or second opinion with Dana-Farber today to meet with an onsite specialist.

Adult Patients:877-442-3324

Pediatric Patients:888-733-4662

Make Appointment OnlineInternational Patients

Online second opinions

Can’t get to Boston? Explore our Online Second Opinion service to get expert advice from Dana-Farber oncologists.

Request a second opinion

Contact & Directions

Email Dana-Farber

Main Number617-632-3000

Toll-Free Number866-408-DFCI (3324)

Maps & DirectionsContact InformationSend us a Question or Comment

How to Help

Discover the ways to give and how to get involved to support Dana-Farber.

Learn More
Give now

Midostaurin (PKC412) for Locally Advanced Rectal Cancer

Status: Recruiting
Phase: Phase 1
Diagnosis: Radiation Oncology
NCT ID: NCT01282502 (View complete trial on
DFCI Protocol ID: 10-457


This study combines midostaurin (PKC412) with radiation and a standard chemotherapy drug call 5-Fluorouracil (5-FU) for subjects with advanced rectal cancer. Midostaurin is a type of kinase inhibitor which works by blocking proteins associated with cancer cell growth. Previous studies also suggest that midostaurin may help increase the effectiveness of radiation therapy. In this research we are looking for the highest dose of midostaurin that can be given safely in combination with standard chemoradiation.


Conducting Institutions:
Dana-Farber Cancer Institute, Massachusetts General Hospital

Overall PI:
Theodore Hong, MD, Massachusetts General Hospital

Site-responsible Investigators:
Harvey Mamon, MD, PhD, Brigham and Women's Hospital

Massachusetts General Hospital: Cancer Trials Call Center, 877-789-6100
Brigham and Women's Hospital: Kristin Roper, 617-525-7387,

Eligibility Criteria

Inclusion Criteria: - Adenocarcinoma of the rectum - T3/4 or N+ disease - Life expectancy > 3 months - Normal organ and marrow function Exclusion Criteria: - Metastatic disease - Pregnant or breastfeeding - Prior radiotherapy - Receiving other investigational agents - History of inflammatory bowel disease - Active scleroderma or CREST syndrome - Uncontrolled intercurrent illness - History of a different malignancy unless disease free for at least 5 years - HIV or active viral hepatitis - Impaired cardiac function
  •   Email
  •   Print
  •   Share
  • Make an Appointment

    • For adults:
      877-442-3324 (877-442-DFCI)

    • Quick access:
      Appointments as soon as the next day for new adult patients

    • For children:
      888-733-4662 (888-PEDI-ONC)

    • Make Appointment Online