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Effect of Eltrombopag Plus Granulocyte Colony-stimulating Factor (G-CSF) on Human CD34+ Cell Mobilization in Multiple Myeloma Patients Undergoing Autologous Stem Cell Transplant (ASCT)

Status: Recruiting
Phase: N/A
Diagnosis: Multiple Myeloma
NCT ID: NCT01286675 (View complete trial on
DFCI Protocol ID: 10-346


Eltrombopag may improve the cell collection available for Autologous Stem Cell Transplant(ASCT). The overall goal is to determine if adding Eltrombopag to the standard ASCT will increase the number of blood cells collected and reduce the number of times blood needs to be collected. This study will also determine the highest dose of Eltrombopag that can be used without causing serious side effects.


Conducting Institutions:
Dana-Farber Cancer Institute, Brigham and Women's Hospital

Overall PI:
Gary Vanasse. M.D., Brigham and Women's Hospital

Site-responsible Investigators:

Dana-Farber Cancer Institute: Muriel Gannon, 617-632-4597,

Eligibility Criteria

Inclusion Criteria: - Multiple myeloma - Stable or responsive disease after at least 2 cycles of conventional chemotherapy - Slated to undergo autologous peripheral blood stem cell transplant - Normal organ and marrow function Exclusion Criteria: - Myocardial infarction within 6 months of treatment - Receiving other study agents - Pregnant or breastfeeding - Uncontrolled intercurrent illness - Evidence of active or recent history of thromboembolic disease - Previous history of primary platelet disorder or bleeding disorder - History of a different malignancy unless disease free for at least 5 years
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