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National Marrow Donor Program Long-Term Donor Follow-Up

Status: Recruiting
Phase: N/A
Diagnosis: Hematopoietic Stem Cell Transplant
NCT ID: NCT01362179 (View complete trial on
DFCI Protocol ID: 10-704


This is an observational study of unstimulated bone marrow (BM) and filgrastim-mobilized peripheral blood stem cell (PBSC) donors. The primary goal is to evaluate the hypothesis that the incidence of targeted malignant, thrombotic and autoimmune disorders after unrelated hematopoietic stem cell donation are similar between unstimulated BM and filgrastim-mobilized PBSC donors.


Conducting Institutions:
Dana-Farber Cancer Institute

Overall PI:
Vincent Ho, MD, Dana-Farber Cancer Institute

Site-responsible Investigators:


Eligibility Criteria

Inclusion Criteria: 1. Unrelated donor who donated either unstimulated BM or filgrastim-mobilized PBSC between July 1, 1999 and approximately five years post study activation. 2. Unrelated donor who received at least one injection of filgrastim or more, but did not donate filgrastim-mobilized PBSC between July 1, 1999 and approximately five years post study activation. 3. Donation was managed by a U.S. NMDP donor center. 4. Signed informed consent for participation in this long-term donor follow-up study. Concurrent enrollment on other studies is permitted. Exclusion Criteria: 1. Unrelated donor who donated filgrastim-mobilized bone marrow. 2. Donation was managed by a non-U.S. donor center. 3. Donor is unable to verbally communicate in any of the following languages: English, Spanish, Mandarin Chinese, Cantonese Chinese, Vietnamese, Korean, or Portuguese.
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