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Status: RecruitingPhase: Phase 2Diagnosis: Gastrointestinal Malignancies, Colorectal CancerNCT ID: NCT01516216
(View complete trial on ClinicalTrials.gov)
DFCI Protocol ID: 11-436
The Vitamin D receptor is found in colon cancer cells. When Vitamin D binds to the receptor in the cancer cells, it may stop cancer cells from growing abnormally and may cause cell death. Vitamin D has been used in other research studies and information from those other research studies suggests that Vitamin D may help in the treatment of colorectal cancer. In this research study, the investigators are comparing standard and higher dose Vitamin D treatment when given in combination with standard treatment for metastatic colorectal cancer. Standard treatment includes the chemotherapy combination of 5-FU, Leucovorin and Oxaliplatin (FOLFOX) with bevacizumab.
Conducting Institutions: Massachusetts General Hospital, Beth-Israel Deaconess Medical Center, Dana-Farber Cancer Institute, Dana Farber Cancer Institute at Milford, DF/BWCC at South Shore Hospital
Overall PI: Kimmie Ng, MD,
Dana-Farber Cancer Institute
Site-responsible Investigators: Rebecca Miksad, MD,
Beth Israel Deaconess Medical CenterRolf Freter, MD, Ph.D.,
Dana Farber Cancer Institute at South ShoreMichael Constantine, M.D.,
Dana Farber Cancer Institute at Milford HosptialDavid P. Ryan, MD,
Massachusetts General Hospital
Contacts: Dana-Farber Cancer Institute:
Gastrointestinal Research Line, 617-632-5960Beth-Israel Deaconess Medical Center:
Cancer Trials Call Center, 617-667-3060Massachusetts General Hospital:
Cancer Trials Call Center, 877-789-6100