Inclusion Criteria: 1. Patients with hematologic malignancies, who are at high risk of complications after conventional myeloablative transplantation 2. Patients must have a 6/6 matched, related donor. Matching at HLA Class II will be based on PCR of sequence specific primers (SSP). Among family member transplants, serologic matching at Class I is sufficient 3. Patient age greater than 18 4. Performance status 0-2 5. Life expectancy of > 100 days without transplantation 6. Written informed consent must be obtained in all cases from the patient Exclusion Criteria: 1. Pregnancy 2. Prior Allogeneic Stem Cell Transplantation from any donor 3. Evidence of HIV infection or active Hepatitis B or C infection 4. Heart failure uncontrolled by medications 5. Total bilirubin > 2.0 mg/dl that is due to hepatocellular dysfunction 6. AST > 90 7. Cholesterol > 300 mg/dl or Triglycerides > 400 mg/dl while adequately treated 8. Uncontrolled bacterial, viral or fungal infection 9. Requirement for voriconazole at the time of hospital admission