Arterial Spin Labeling Blood Flow MRI for Evaluation of Response to Antiangiogenic and Targeted Therapies of Renal Cell Carcinoma (RCC)
Status: Recruiting
Phase: N/A
Diagnosis: Kidney Cancer
NCT ID: NCT00749320
(View complete trial on ClinicalTrials.gov)
DFCI Protocol ID: 08-078
The purpose of this study is to assess magnetic resonance imaging (MRI) as a tool to track tumor growth for renal cell carcinoma while the participant is receiving clinical treatment therapy with sunitinib or pazopanib. An MRI is a sophisticated type of scan that uses powerful magnets to make clearer images or to focus on detailed medical information in the participants abdomen and pelvis. This imaging done for this study will use the ASL MRI technique that allows us to see blood flow changes which possibly may indicated tumor growth.
Conducting Institutions:
Dana-Farber Cancer Institute, Beth-Israel Deaconess Medical Center, Brigham and Women's Hospital
Overall PI:
Toni Choueiri, MD,
Dana-Farber Cancer Institute
Site-responsible Investigators:
Ivan Pedrosa, MD,
Beth Israel Deaconess Medical Center
Contacts:
Beth-Israel Deaconess Medical Center:
Cancer Trials Call Center, 617-667-3060
Dana-Farber Cancer Institute:
Judith Prisby, 617-632-5068,
jprisby@partners.org
Eligibility Criteria
Inclusion Criteria:
- Patients diagnosed with metastatic renal cell carcinoma and who will initiate
sunitinib
- Enrolled on protocol 06-105, "Collection of specimens and clinical data from patients
with renal cell carcinoma treated with targeted therapies"
- Found to have tumors that are 2.5cm or greater as determined by CT imaging
- Candidate lesions for ASL MRI should be 2.5cm or greater. Order of preference of
lesion location will be as follows: abdominal lesions, bone lesions and chest lesions
Exclusion Criteria:
- Contraindication to MRI