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Status: RecruitingPhase: Phase 2Diagnosis: Pediatric Hematopoietic Stem Cell Transplant (HSCT), Pediatric LeukemiaNCT ID: NCT01690520
(View complete trial on ClinicalTrials.gov)
DFCI Protocol ID: 13-042
This randomized phase II trial studies how well donor umbilical cord blood transplant with or without ex-vivo expanded cord blood progenitor cells works in treating patients with acute myeloid leukemia, acute lymphoblastic leukemia, chronic myelogenous leukemia, or myelodysplastic syndromes. Giving chemotherapy and total-body irradiation before a donor umbilical cord blood transplant helps stop the growth of cancer cells. It may also stop the patient's immune system from rejecting the donor's cells. When the healthy stem cells and ex-vivo expanded cord blood progenitor cells are infused into the patient they may help the patient's bone marrow make stem cells, red blood cells, white blood cells, and platelets. It is not yet known whether giving donor umbilical cord blood transplant plus ex-vivo expanded cord blood progenitor cells is more effective than giving a donor umbilical cord blood transplant alone.
Conducting Institutions: Dana-Farber Cancer Institute, Children's Hospital Boston
Overall PI: Christine Duncan, MD,
Dana-Farber Cancer Institute
Contacts: Dana-Farber Cancer Institute:
Childrens Hospital Pediatric Clinical Translation Investigation Program CTIP,