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Status: RecruitingPhase: Phase 2Diagnosis: Head and Neck CancerNCT ID: NCT01898494
(View complete trial on ClinicalTrials.gov)
DFCI Protocol ID: 14-044
This randomized phase II trial studies how well transoral surgery followed by low-dose or standard-dose radiation therapy works in treating patients with human papilloma virus (HPV) positive stage III-IVA oropharyngeal cancer. Radiation therapy uses high-energy x-rays to kill tumor cells. Drugs used in chemotherapy work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving radiation therapy with chemotherapy may kill any tumor cells that remain after surgery. It is not yet known how much extra treatment needs to be given after surgery.
Conducting Institutions: Brigham and Women's Hospital, Dana-Farber Cancer Institute
Overall PI: Tom Thomas, MD,
Dana Farber Cancer Institute
Contacts: Dana-Farber Cancer Institute: