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Status: RecruitingPhase: Phase 1Diagnosis: Solid Tumor/Phase INCT ID: NCT02142803
(View complete trial on ClinicalTrials.gov)
DFCI Protocol ID: 14-079
This phase I trial studies the side effects and best dose of raptor/rictor-mammalian target of rapamycin (mTOR) (TORC1/2) inhibitor MLN0128 when given in combination with bevacizumab in treating patients with glioblastoma, a type of brain tumor, or a solid tumor that has spread and not responded to standard treatment. TORC1/2 inhibitor MLN0128 may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Monoclonal antibodies, such as bevacizumab, may interfere with the ability of tumor cells to grow and spread. Bevacizumab may also stop the progression of tumors by blocking the growth of new blood vessels necessary for tumor growth.
Conducting Institutions: Dana-Farber Cancer Institute, Brigham and Women's Hospital, Massachusetts General Hospital
Overall PI: Lakshmi Nayak M.D.,
Dana Farber Cancer Institute
Contacts: Dana-Farber Cancer Institute:
Andrew Wolanski, 617-632-6623,