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Chemical Biology Initiative

  • The Chemical Biology Initiative provides molecular solutions to problems posed by cancer, fostering basic biological discoveries and the translation of these discoveries into new drugs for cancer patients.

    lab equipment

    The scientific programs of Chemical Biology Initiative's core investigators focus on:

    • The discovery of novel protein kinase inhibitors
    • Determining the structure of signaling complexes that are involved in cancer
    • Creation of stapled peptides to study aberrant cell death pathways in cancer
    • Using NMR as a structure-guided approach to investigate protein-protein interactions
    • The discovery of novel deubiquitinylase inhibitors
    • Investigation of the mechanism of ubiquitin ligases in cancer
    • The discovery of novel inhibitors of epigenetic targets and transcription factors in cancer

    Contact Us

    If you are interested in collaborating with our Chemical Biology investigators — or in finding out more about the research being conducted by the Chemical Biology Initiative — please contact Nathanael Gray, PhD, at nathanael_gray@dfci.harvard.edu.