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Recent Publications from the Chemical Biology Initiative

  • Longwood Center

    View a selection of recent publications from investigators in the Chemical Biology Initiative:

    Nishikawa JL, Boeszoermenyi A, Vale-Silva LA, Torelli R, Posteraro B, Sohn YJ, Ji F, Gelev V, Sanglard D, Sanguinetti M, Sadreyev RI, Mukherjee G, Bhyravabhotla J, Buhrlage SJ, Gray NS, Wagner G, Näär AM, Arthanari H. Inhibiting fungal multidrug resistance by disrupting an activator-Mediator interaction . Nature 2016 Feb 25; 530(7591):485-9. PMID: 26886795.

    Cavadini, S., Fischer, E.S., Bunker, R.D., Potenza, A., Lingaraju, G.M., Goldie, K.N., Mohamed, W.I., Faty, M., Petzold, G., Beckwith, R.E.J., Tichkule, R., Hassiepen, U., Abdulrahman, W., Pantelic, R.S., Matsumoto, S., Sugasawa, K., Stahlberg, H., Thomä, N.H. Cullin-RING ubiquitin E3 ligase regulation by the COP9 signalosome . Nature 2016; 531(7596):598-603.

    Tan L, Akahane K, McNally R, Reyskens KM, Ficarro SB, Liu S, Herter-Sprie GS, Koyama S, Pattison MJ, Labella K, Johannessen L, Akbay EA, Wong KK, Frank DA, Marto JA, Look TA, Arthur JS, Eck MJ, Gray NS. Development of Selective Covalent Janus Kinase 3 Inhibitors . J Med Chem. 2015 Aug 27; 58(16):6589-606. PubMed PMID: 26258521; PubMed Central PMCID: PMC4777322.

    Barclay LA, Wales TE, Garner TP, Wachter F, Lee S, Guerra RM, Stewart ML, Braun CR, Bird GH, Gavathiotis E, Engen JR, Walensky LD. Inhibition of Pro-apoptotic BAX by a noncanonical interaction mechanism . Mol Cell. 2015 Mar 5; 57(5):873-86 PubMed PMID: 25684204; PubMed Central PMCID: PMC4384643.

    Ritorto MS, Ewan R, Perez-Oliva AB, Knebel A, Buhrlage SJ, Wightman M, Kelly SM, Wood NT, Virdee S, Gray NS, Morrice NA, Alessi DR, Trost M. Screening of DUB activity and specificity by MALDI-TOF mass spectrometry . Nat Commun. 2014 Aug 27; 5:4763. PubMed PMID: 25159004; PubMed Central PMCID: PMC4147353.

    Filippakopoulos P, Qi J, Picaud S, Shen Y, Smith WB, Fedorov O, Morse EM, Keates T, Hickman TT, Felletar I, Philpott M, Munro S, West N, Cameron MJ, Heightman TD, Thangue NL, Kung AL, French CA, Wiest O, Knapp S, Bradner JE. Selective inhibition of BET bromodomains . Nature, 2010; 468, 1067-1073. PMCID: PMC3010259