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Stem Cell Transplantation at Dana-Farber/Brigham and Women's Cancer Center: A Photo Tour

  • Vincent Ho, MD, with a stem cell transplant patient

    Every year, thousands of people are diagnosed with blood cancers and other diseases of the blood and bone marrow. For some of these patients, the best course of treatment is a stem cell or bone marrow transplant.

    If you or a loved one may need a stem cell transplant, this photo tour is designed for you. We hope it will give you a helpful overview of the transplant process, as well as some of the many resources available to you in the Dana-Farber/Brigham and Women's Cancer Center (DF/BWCC) Adult Stem Cell Transplantation Program.

    While we know that preparing for a stem cell transplant is a difficult experience for you and your loved ones, rest assured that we will be with you at every step of the way throughout your transplant journey. We consider you and your caregivers to be part of the care team, too, and encourage you to ask questions and share your thoughts with us at any time.

  • How Stem Cells Are Used

    How stem cells are used to treat patients like you

    howstem cells are used

    What are stem cells?

    Stem cells are the "building blocks" of bone marrow and blood formation. They form white blood cells (which fight infections), red blood cells (which carry oxygen throughout the body), and platelets (which allow blood to clot, helping wounds heal) – all of the components your immune system needs to function.

    Where in the body are stem cells located?

    Stem cells are found in bone marrow (the tissue inside the bones) and in peripheral blood (the blood that circulates throughout the body, carrying vital nutrients). They are also found in the umbilical cord blood of newborn babies.

    What are the main types of stem cell transplant?

    Transplants performed here at DF/BWCC are either autologous (using your own stem cells) or allogeneic (using another person’s stem cells:

    • Autologous Transplant: Your own stem cells/bone marrow will be harvested from your body.
    • Allogeneic Transplant: >A donor — someone who is either related to you, or who is unrelated but has a type of cell protein called HLA that closely matches yours – will have their stem cells or bone marrow harvested for your transplant.

    Stem cell donor services, collection, and processing

    stem cell donor services

    Whether you are donating your own stem cells for your transplant, or are receiving cells from either a related or unrelated donor, we have all of the facilities and support services you need to make the process go smoothly.

    If I am not using my own stem cells for a transplant, how will I get the donor cells I need?

    If you are not using your own cells for an autologous transplant, your specially trained donor search coordinator can help find a donor for you. Dana-Farber is accredited by the National Marrow Donor Program (NMDP) to coordinate donor searches for patients. If you need an allogeneic transplant but do not have a related donor who is a match, your donor coordinator will help organize the search. The NMDP's Be The Match Registry® and all other appropriate unrelated donor registries and cord blood banks will be contacted to help find a suitable donor for you.

    What happens during the transplant process?

    During the actual stem cell transplant, your body is infused with healthy stem cells (either your own if you have an autologous transplant, or a donor’s if you have an allogeneic transplant). The infused stem cells then grow and produce all of the different parts of the blood that both your body and your immune system need.

    You will be closely monitored before and after your stem cell transplant. After you have received your new stem cells, your care team will check your blood counts every day to monitor for engraftment. Engraftment is when your transplanted stem cells begin to make new blood (red blood cells, platelets, and other components of the immune system) within your body. The time it takes to reach engraftment depends on several factors, including stem cell source, the type of transplant, and your pre-transplant therapies.

    Where are the stem cells used for transplant at DF/BWCC processed?

    Dana-Farber is home to the Connell and O’Reilly Families Cell Manipulation Core Facility, which is New England’s only state-of-the-art cell therapy facility at an academic medical center. Our facility processes all of the stem cells we use for transplant and other patient care purposes. How does DF/BWCC ensure the quality and safety of the stem cells used for transplant? DF/BWCC has an entire department dedicated to ensuring the highest standards of quality in the manufacturing and use of stem cells, as well as all other types of cellular products used for patients.