Dipanjan Chowdhury, PhD

An autoinhibited state of 53BP1 revealed by small molecule antagonists and protein engineering. Nat Commun. 2023 Sep 29; 14(1):6091. View in: Pubmed

Targeting MCL-1 triggers DNA damage and an anti-proliferative response independent from apoptosis induction. Cell Rep. 2023 Sep 27; 42(10):113176. View in: Pubmed

Dynamics of the DYNLL1-MRE11 complex regulate DNA end resection and recruitment of Shieldin to DSBs. Nat Struct Mol Biol. 2023 Sep 11. View in: Pubmed

An autoinhibited state of 53BP1 revealed by small molecule antagonists and protein engineering. bioRxiv. 2023 Jul 18. View in: Pubmed

Identification of BRCA1/2 mutation female carriers using circulating microRNA profiles. Nat Commun. 2023 Jun 08; 14(1):3350. View in: Pubmed

Serum miRNA-based signature indicates radiation exposure and dose in humans: A multicenter diagnostic biomarker study. Radiother Oncol. 2023 Aug; 185:109731. View in: Pubmed

Dynamics of the DYNLL1/MRE11 complex regulates DNA end resection and recruitment of the Shieldin complex to DSBs. bioRxiv. 2023 Mar 27. View in: Pubmed

CCAR2 functions downstream of the Shieldin complex to promote double-strand break end-joining. Proc Natl Acad Sci U S A. 2022 12 06; 119(49):e2214935119. View in: Pubmed

Targeting replication stress in cancer therapy. Nat Rev Drug Discov. 2023 01; 22(1):38-58. View in: Pubmed

A druggable addiction to de novo pyrimidine biosynthesis in diffuse midline glioma. Cancer Cell. 2022 09 12; 40(9):957-972.e10. View in: Pubmed

TOPBPing up DSBs with PARylation. Mol Cell. 2022 07 21; 82(14):2538-2540. View in: Pubmed

A Translational Model to Improve Early Detection of Epithelial Ovarian Cancers. Front Oncol. 2022; 12:786154. View in: Pubmed

Combined PARP and HSP90 inhibition: preclinical and Phase 1 evaluation in patients with advanced solid tumours. Br J Cancer. 2022 04; 126(7):1027-1036. View in: Pubmed

MicroRNA profiling in a case-control study of African American women with uterine serous carcinoma. Gynecol Oncol. 2021 12; 163(3):453-458. View in: Pubmed

A Replication stress biomarker is associated with response to gemcitabine versus combined gemcitabine and ATR inhibitor therapy in ovarian cancer. Nat Commun. 2021 09 22; 12(1):5574. View in: Pubmed

ASTE1 cutting to block DNA end resection. Nat Cell Biol. 2021 08; 23(8):818-819. View in: Pubmed

TIRR inhibits the 53BP1-p53 complex to alter cell-fate programs. Mol Cell. 2021 06 17; 81(12):2583-2595.e6. View in: Pubmed

Correction to: A prototypical non-malignant epithelial model to study genome dynamics and concurrently monitor micro-RNAs and proteins in situ during oncogene-induced senescence. BMC Genomics. 2021 May 05; 22(1):327. View in: Pubmed

CHK1 Inhibitor Blocks Phosphorylation of FAM122A and Promotes Replication Stress. Mol Cell. 2020 11 05; 80(3):410-422.e6. View in: Pubmed

Tumor protein expression of the DNA repair gene BRCA1 and lethal prostate cancer. Carcinogenesis. 2020 07 14; 41(7):904-908. View in: Pubmed

Berzosertib plus gemcitabine versus gemcitabine alone in platinum-resistant high-grade serous ovarian cancer: a multicentre, open-label, randomised, phase 2 trial. Lancet Oncol. 2020 07; 21(7):957-968. View in: Pubmed

Author Correction: Immunogenomic profiling determines responses to combined PARP and PD-1 inhibition in ovarian cancer. Nat Commun. 2020 05 18; 11(1):2543. View in: Pubmed

Endogenous oxidized DNA bases and APE1 regulate the formation of G-quadruplex structures in the genome. Proc Natl Acad Sci U S A. 2020 05 26; 117(21):11409-11420. View in: Pubmed

Immunogenomic profiling determines responses to combined PARP and PD-1 inhibition in ovarian cancer. Nat Commun. 2020 03 19; 11(1):1459. View in: Pubmed

A systemic approach to screening high-throughput RT-qPCR data for a suitable set of reference circulating miRNAs. BMC Genomics. 2020 Jan 31; 21(1):111. View in: Pubmed

TRIP13 regulates DNA repair pathway choice through REV7 conformational change. Nat Cell Biol. 2020 01; 22(1):87-96. View in: Pubmed

CDK phosphorylation of TRF2 controls t-loop dynamics during the cell cycle. Nature. 2019 11; 575(7783):523-527. View in: Pubmed

Circulating microRNAs as Biomarkers of Radiation Exposure: A Systematic Review and Meta-Analysis. Int J Radiat Oncol Biol Phys. 2020 02 01; 106(2):390-402. View in: Pubmed

A mitotic CDK5-PP4 phospho-signaling cascade primes 53BP1 for DNA repair in G1. Nat Commun. 2019 09 18; 10(1):4252. View in: Pubmed

Identification of LIMK2 as a therapeutic target in castration resistant prostate cancer. Cancer Lett. 2019 04 28; 448:182-196. View in: Pubmed

DYNLL1 binds to MRE11 to limit DNA end resection in BRCA1-deficient cells. Nature. 2018 11; 563(7732):522-526. View in: Pubmed

Mechanism of 53BP1 activity regulation by RNA-binding TIRR and a designer protein. Nat Struct Mol Biol. 2018 07; 25(7):591-600. View in: Pubmed

Potential of serum microRNAs as biomarkers of radiation injury and tools for individualization of radiotherapy. Transl Res. 2018 11; 201:71-83. View in: Pubmed

Dual HDAC and PI3K Inhibition Abrogates NF?B- and FOXM1-Mediated DNA Damage Response to Radiosensitize Pediatric High-Grade Gliomas. Cancer Res. 2018 07 15; 78(14):4007-4021. View in: Pubmed

Multifaceted Impact of MicroRNA 493-5p on Genome-Stabilizing Pathways Induces Platinum and PARP Inhibitor Resistance in BRCA2-Mutated Carcinomas. Cell Rep. 2018 04 03; 23(1):100-111. View in: Pubmed

Mutational signatures reveal the role of RAD52 in p53-independent p21-driven genomic instability. Genome Biol. 2018 03 16; 19(1):37. View in: Pubmed

Serum microRNAs - potent biomarkers for radiation biodosimetry. Oncotarget. 2018 Mar 06; 9(18):14038-14039. View in: Pubmed

EWS/FLI Confers Tumor Cell Synthetic Lethality to CDK12 Inhibition in Ewing Sarcoma. Cancer Cell. 2018 02 12; 33(2):202-216.e6. View in: Pubmed

A prototypical non-malignant epithelial model to study genome dynamics and concurrently monitor micro-RNAs and proteins in situ during oncogene-induced senescence. BMC Genomics. 2018 01 10; 19(1):37. View in: Pubmed

Diagnostic potential for a serum miRNA neural network for detection of ovarian cancer. Elife. 2017 10 31; 6. View in: Pubmed

TIRR and 53BP1- partners in arms. Cell Cycle. 2017 07 03; 16(13):1235-1236. View in: Pubmed

Evolutionarily conserved serum microRNAs predict radiation-induced fatality in nonhuman primates. Sci Transl Med. 2017 03 01; 9(379). View in: Pubmed

TIRR regulates 53BP1 by masking its histone methyl-lysine binding function. Nature. 2017 03 09; 543(7644):211-216. View in: Pubmed

Clear cell ovarian cancers with microsatellite instability: A unique subset of ovarian cancers with increased tumor-infiltrating lymphocytes and PD-1/PD-L1 expression. Oncoimmunology. 2017; 6(2):e1277308. View in: Pubmed

334 A Functional Screen Identifies miRNAs that Induce Radioresistance in Glioblastomas. Neurosurgery. 2016 Aug; 63 Suppl 1:197-8. View in: Pubmed

Circulating miR-29a and miR-150 correlate with delivered dose during thoracic radiation therapy for non-small cell lung cancer. Radiat Oncol. 2016 Apr 27; 11:61. View in: Pubmed

Association and prognostic significance of BRCA1/2-mutation status with neoantigen load, number of tumor-infiltrating lymphocytes and expression of PD-1/PD-L1 in high grade serous ovarian cancer. Oncotarget. 2016 Mar 22; 7(12):13587-98. View in: Pubmed

Platinum and PARP Inhibitor Resistance Due to Overexpression of MicroRNA-622 in BRCA1-Mutant Ovarian Cancer. Cell Rep. 2016 Jan 26; 14(3):429-439. View in: Pubmed

Serum microRNAs are early indicators of survival after radiation-induced hematopoietic injury. Sci Transl Med. 2015 May 13; 7(287):287ra69. View in: Pubmed

Emerging role of protein phosphatases changes the landscape of phospho-signaling in DNA damage response. DNA Repair (Amst). 2015 Aug; 32:58-65. View in: Pubmed

A functional screen identifies miRs that induce radioresistance in glioblastomas. Mol Cancer Res. 2014 Dec; 12(12):1767-78. View in: Pubmed

Phosphorylated RPA recruits PALB2 to stalled DNA replication forks to facilitate fork recovery. J Cell Biol. 2014 Aug 18; 206(4):493-507. View in: Pubmed

A genome-wide miRNA screen revealed miR-603 as a MGMT-regulating miRNA in glioblastomas. Oncotarget. 2014 Jun 30; 5(12):4026-39. View in: Pubmed

KAP-1 promotes resection of broken DNA ends not protected by ?-H2AX and 53BP1 in G1-phase lymphocytes. Mol Cell Biol. 2014 Aug; 34(15):2811-21. View in: Pubmed

Sublethal concentrations of 17-AAG suppress homologous recombination DNA repair and enhance sensitivity to carboplatin and olaparib in HR proficient ovarian cancer cells. Oncotarget. 2014 May 15; 5(9):2678-87. View in: Pubmed

MicroRNAs down-regulate homologous recombination in the G1 phase of cycling cells to maintain genomic stability. Elife. 2014 Apr 30; 3:e02445. View in: Pubmed

Distinct phosphatases antagonize the p53 response in different phases of the cell cycle. Proc Natl Acad Sci U S A. 2014 May 20; 111(20):7313-8. View in: Pubmed

Dephosphorylation enables the recruitment of 53BP1 to double-strand DNA breaks. Mol Cell. 2014 May 08; 54(3):512-25. View in: Pubmed

EGFR-mediated chromatin condensation protects KRAS-mutant cancer cells against ionizing radiation. Cancer Res. 2014 May 15; 74(10):2825-34. View in: Pubmed

Association of microRNAs and pathologic response to preoperative chemotherapy in triple negative breast cancer: preliminary report. Mol Biol Rep. 2014 May; 41(5):2851-7. View in: Pubmed

A p21-ZEB1 complex inhibits epithelial-mesenchymal transition through the microRNA 183-96-182 cluster. Mol Cell Biol. 2014 Feb; 34(3):533-50. View in: Pubmed

Stabilization of mutant BRCA1 protein confers PARP inhibitor and platinum resistance. Proc Natl Acad Sci U S A. 2013 Oct 15; 110(42):17041-6. View in: Pubmed

Charity begins at home: non-coding RNA functions in DNA repair. Nat Rev Mol Cell Biol. 2013 03; 14(3):181-9. View in: Pubmed

Inhibition of non-homologous end joining repair impairs pancreatic cancer growth and enhances radiation response. PLoS One. 2012; 7(6):e39588. View in: Pubmed

Phosphoproteomic analysis reveals that PP4 dephosphorylates KAP-1 impacting the DNA damage response. EMBO J. 2012 May 16; 31(10):2403-15. View in: Pubmed

DNA breaks and chromosome pulverization from errors in mitosis. Nature. 2012 Jan 18; 482(7383):53-8. View in: Pubmed

MYC is activated by USP2a-mediated modulation of microRNAs in prostate cancer. Cancer Discov. 2012 Mar; 2(3):236-47. View in: Pubmed

What goes on must come off: phosphatases gate-crash the DNA damage response. Trends Biochem Sci. 2011 Nov; 36(11):569-77. View in: Pubmed

Translational control of TOP2A influences doxorubicin efficacy. Mol Cell Biol. 2011 Sep; 31(18):3790-801. View in: Pubmed

Personalized therapy for urothelial cancer: review of the clinical evidence. Clin Investig (Lond). 2011 Apr; 1(4):546-555. View in: Pubmed

miR-182-mediated downregulation of BRCA1 impacts DNA repair and sensitivity to PARP inhibitors. Mol Cell. 2011 Jan 21; 41(2):210-20. View in: Pubmed

A PP4 phosphatase complex dephosphorylates RPA2 to facilitate DNA repair via homologous recombination. Nat Struct Mol Biol. 2010 Mar; 17(3):365-72. View in: Pubmed

Distinct passenger strand and mRNA cleavage activities of human Argonaute proteins. Nat Struct Mol Biol. 2009 Dec; 16(12):1259-66. View in: Pubmed

miR-24 Inhibits cell proliferation by targeting E2F2, MYC, and other cell-cycle genes via binding to "seedless" 3'UTR microRNA recognition elements. Mol Cell. 2009 Sep 11; 35(5):610-25. View in: Pubmed

The cytotoxic T lymphocyte protease granzyme A cleaves and inactivates poly(adenosine 5'-diphosphate-ribose) polymerase-1. Blood. 2009 Aug 06; 114(6):1205-16. View in: Pubmed

Human RIF1 encodes an anti-apoptotic factor required for DNA repair. Carcinogenesis. 2009 Aug; 30(8):1314-9. View in: Pubmed

miR-24-mediated downregulation of H2AX suppresses DNA repair in terminally differentiated blood cells. Nat Struct Mol Biol. 2009 May; 16(5):492-8. View in: Pubmed

Protein phosphatase PP4 is overexpressed in human breast and lung tumors. Cell Res. 2008 Sep; 18(9):974-7. View in: Pubmed

A PP4-phosphatase complex dephosphorylates gamma-H2AX generated during DNA replication. Mol Cell. 2008 Jul 11; 31(1):33-46. View in: Pubmed

Death by a thousand cuts: granzyme pathways of programmed cell death. Annu Rev Immunol. 2008; 26:389-420. View in: Pubmed

RNA interference and cancer: endogenous pathways and therapeutic approaches. Adv Exp Med Biol. 2008; 615:299-329. View in: Pubmed

Granzymes and cell death. Methods Enzymol. 2008; 442:213-30. View in: Pubmed

Repeat organization and epigenetic regulation of the DH-Cmu domain of the immunoglobulin heavy-chain gene locus. Mol Cell. 2007 Sep 07; 27(5):842-50. View in: Pubmed

Mutations in the gene encoding the 3'-5' DNA exonuclease TREX1 are associated with systemic lupus erythematosus. Nat Genet. 2007 Sep; 39(9):1065-7. View in: Pubmed

A mutation in TREX1 that impairs susceptibility to granzyme A-mediated cell death underlies familial chilblain lupus. J Mol Med (Berl). 2007 May; 85(5):531-7. View in: Pubmed

The exonuclease TREX1 is in the SET complex and acts in concert with NM23-H1 to degrade DNA during granzyme A-mediated cell death. Mol Cell. 2006 Jul 07; 23(1):133-42. View in: Pubmed

Granzyme A, which causes single-stranded DNA damage, targets the double-strand break repair protein Ku70. EMBO Rep. 2006 Apr; 7(4):431-7. View in: Pubmed

gamma-H2AX dephosphorylation by protein phosphatase 2A facilitates DNA double-strand break repair. Mol Cell. 2005 Dec 09; 20(5):801-9. View in: Pubmed

An siRNA-based microbicide protects mice from lethal herpes simplex virus 2 infection. Nature. 2006 Jan 05; 439(7072):89-94. View in: Pubmed

A phosphatase complex that dephosphorylates gammaH2AX regulates DNA damage checkpoint recovery. Nature. 2006 Jan 26; 439(7075):497-501. View in: Pubmed

Potential roles for short RNAs in lymphocytes. Immunol Cell Biol. 2005 Jun; 83(3):201-10. View in: Pubmed

Antibody mediated in vivo delivery of small interfering RNAs via cell-surface receptors. Nat Biotechnol. 2005 Jun; 23(6):709-17. View in: Pubmed

RNAi and RNA-based regulation of immune system function. Adv Immunol. 2005; 88:267-92. View in: Pubmed

Mechanisms for feedback inhibition of the immunoglobulin heavy chain locus. Curr Opin Immunol. 2004 Apr; 16(2):235-40. View in: Pubmed