Ennio A. Chiocca, MD, PhD

Ennio A. Chiocca, MD, PhD

Neurosurgery

Languages Spoken:

Italian

Contact Information

Office Phone Number

617-525-9419

Fax

617-734-8342

Appointments

617-732-6600

Researcher

Physician

Surgical Director, Center for Neuro-Oncology
Professor of Neurosurgery, Harvard Medical School

Centers/Programs

CNS Lymphoma Center

Clinical Interests

Brain, spine, and nerve tumors, Peripheral nerve surgery, Spine surgery

Board Certification

  • Neurological Surgery, 2000

Residency

  • Massachusetts General Hospital, Neurological Surgery

Medical School

  • University of Texas Medical School at Houston

Publications

    • Inaugural Results of the Individualized Screening Trial of Innovative Glioblastoma Therapy: A Phase II Platform Trial for Newly Diagnosed Glioblastoma Using Bayesian Adaptive Randomization. J Clin Oncol. 2023 Sep 18; JCO2300493. View in: Pubmed

    • Intratumoral drug-releasing microdevices allow in situ high-throughput pharmaco phenotyping in patients with gliomas. Sci Transl Med. 2023 Sep 06; 15(712):eadi0069. View in: Pubmed

    • Combined gene therapies for high-grade glioma. Lancet Oncol. 2023 Sep; 24(9):949-950. View in: Pubmed

    • Intracranial stimulation for brain cancer-The case for implantable, intracranial tumor treating fields. Neurooncol Adv. 2023 Jan-Dec; 5(1):vdad100. View in: Pubmed

    • Recent oncolytic virotherapy clinical trials outline a roadmap for the treatment of high-grade glioma. Neurooncol Adv. 2023 Jan-Dec; 5(1):vdad081. View in: Pubmed

    • Clinical Importance of the lncRNA NEAT1 in Cancer Patients Treated with Immune Checkpoint Inhibitors. Clin Cancer Res. 2023 06 13; 29(12):2226-2238. View in: Pubmed

    • Uncovering transcriptomic landscape alterations of CAN-2409 in in vitro and in vivo glioma models. Front Med (Lausanne). 2023; 10:1140352. View in: Pubmed

    • PPRX-1701, a nanoparticle formulation of 6'-bromoindirubin acetoxime, improves delivery and shows efficacy in preclinical GBM models. Cell Rep Med. 2023 05 16; 4(5):101019. View in: Pubmed

    • The Role of Long Noncoding Ribonucleic Acids in Glioblastoma: What the Neurosurgeon Should Know. Neurosurgery. 2023 06 01; 92(6):1104-1111. View in: Pubmed

    • Reduced time to imaging, length of stay, and hospital charges following implementation of a novel postoperative pathway for craniotomy. J Neurosurg. 2023 Jan 06; 1-12. View in: Pubmed

    • Cerebellar High-Grade Glioma: A Translationally Oriented Review of the Literature. Cancers (Basel). 2022 Dec 28; 15(1). View in: Pubmed

    • Dual Immunostimulatory Pathway Agonism through a Synthetic Nanocarrier Triggers Robust Anti-Tumor Immunity in Murine Glioblastoma. Adv Mater. 2023 Feb; 35(7):e2208782. View in: Pubmed

    • The emerging field of oncolytic virus-based cancer immunotherapy. Trends Cancer. 2023 02; 9(2):122-139. View in: Pubmed

    • Specific targeting of glioblastoma with an oncolytic virus expressing a cetuximab-CCL5 fusion protein via innate and adaptive immunity. Nat Cancer. 2022 11; 3(11):1318-1335. View in: Pubmed

    • Variants of the adeno-associated virus serotype 9 with enhanced penetration of the blood-brain barrier in rodents and primates. Nat Biomed Eng. 2022 11; 6(11):1257-1271. View in: Pubmed

    • Treat and repeat: oncolytic virus therapy for brain cancer. Nat Med. 2022 08; 28(8):1540-1542. View in: Pubmed

    • Perturbing DDR signaling enhances cytotoxic effects of local oncolytic virotherapy and modulates the immune environment in glioma. Mol Ther Oncolytics. 2022 Sep 15; 26:275-288. View in: Pubmed

    • Carole A. Miller, MD: Matriarch of the Ohio State University's Department of Neurosurgery. World Neurosurg. 2022 Oct; 166:33-38. View in: Pubmed

    • STING activation promotes robust immune response and NK cell-mediated tumor regression in glioblastoma models. Proc Natl Acad Sci U S A. 2022 07 12; 119(28):e2111003119. View in: Pubmed

    • Clinical utility of targeted next-generation sequencing assay in IDH-wildtype glioblastoma for therapy decision-making. Neuro Oncol. 2022 07 01; 24(7):1140-1149. View in: Pubmed

    • The current state of glioma data registries. Neurooncol Adv. 2022 Jan-Dec; 4(1):vdac099. View in: Pubmed

    • Combined immunotherapy with controlled interleukin-12 gene therapy and immune checkpoint blockade in recurrent glioblastoma: An open-label, multi-institutional phase I trial. Neuro Oncol. 2022 06 01; 24(6):951-963. View in: Pubmed

    • Target receptor identification and subsequent treatment of resected brain tumors with encapsulated and engineered allogeneic stem cells. Nat Commun. 2022 05 19; 13(1):2810. View in: Pubmed

    • Agent-based computational modeling of glioblastoma predicts that stromal density is central to oncolytic virus efficacy. iScience. 2022 Jun 17; 25(6):104395. View in: Pubmed

    • NOTCH-Induced MDSC Recruitment after oHSV Virotherapy in CNS Cancer Models Modulates Antitumor Immunotherapy. Clin Cancer Res. 2022 04 01; 28(7):1460-1473. View in: Pubmed

    • Advances in local therapy for glioblastoma - taking the fight to the tumour. Nat Rev Neurol. 2022 04; 18(4):221-236. View in: Pubmed

    • Tumor-Associated Macrophages/Microglia in Glioblastoma Oncolytic Virotherapy: A Double-Edged Sword. Int J Mol Sci. 2022 Feb 04; 23(3). View in: Pubmed

    • Immune Checkpoint Inhibition in GBM Primed with Radiation by Engineered Extracellular Vesicles. ACS Nano. 2022 02 22; 16(2):1940-1953. View in: Pubmed

    • Activity of PD-1 blockade with nivolumab among patients with recurrent atypical/anaplastic meningioma: phase II trial results. Neuro Oncol. 2022 01 05; 24(1):101-113. View in: Pubmed

    • Autoimmune Cytopenias and Dysregulated Immunophenotype Act as Warning Signs of Inborn Errors of Immunity: Results From a Prospective Study. Front Immunol. 2021; 12:790455. View in: Pubmed

    • Systemic high-dose dexamethasone treatment may modulate the efficacy of intratumoral viral oncolytic immunotherapy in glioblastoma models. J Immunother Cancer. 2022 01; 10(1). View in: Pubmed

    • Quantitative imaging of apoptosis following oncolytic virotherapy by magnetic resonance fingerprinting aided by deep learning. Nat Biomed Eng. 2022 05; 6(5):648-657. View in: Pubmed

    • Glial and myeloid heterogeneity in the brain tumour microenvironment. Nat Rev Cancer. 2021 12; 21(12):786-802. View in: Pubmed

    • The Evolving Role of Neurosurgical Intervention for Central Nervous System Tumors. Hematol Oncol Clin North Am. 2022 02; 36(1):63-75. View in: Pubmed

    • Treatment of glioblastoma with current oHSV variants reveals differences in efficacy and immune cell recruitment. Mol Ther Oncolytics. 2021 Sep 24; 22:444-453. View in: Pubmed

    • Evolution of the Neurosurgeon's Role in Clinical Trials for Glioblastoma: A Systematic Overview of the Clinicaltrials.Gov Database. Neurosurgery. 2021 07 15; 89(2):196-203. View in: Pubmed

    • The Current Landscape of Oncolytic Herpes Simplex Viruses as Novel Therapies for Brain Malignancies. Viruses. 2021 06 17; 13(6). View in: Pubmed

    • Neurosurgery Research and Education Foundation funding conversion to National Institutes of Health funding. J Neurosurg. 2022 Jan 01; 136(1):287-294. View in: Pubmed

    • Cytomegalovirus infection of glioblastoma cells leads to NF-?B dependent upregulation of the c-MET oncogenic tyrosine kinase. Cancer Lett. 2021 08 10; 513:26-35. View in: Pubmed

    • Role of surgery for glioblastoma: response to letters from Dr. Gerritsen and his colleagues and Dr. Vargas Lopez. Neuro Oncol. 2021 03 25; 23(3):506-507. View in: Pubmed

    • Unique challenges for glioblastoma immunotherapy-discussions across neuro-oncology and non-neuro-oncology experts in cancer immunology. Meeting Report from the 2019 SNO Immuno-Oncology Think Tank. Neuro Oncol. 2021 03 25; 23(3):356-375. View in: Pubmed

    • Oncolytic Virus Therapy Alters the Secretome of Targeted Glioblastoma Cells. Cancers (Basel). 2021 Mar 14; 13(6). View in: Pubmed

    • Biographies of international women leaders in neurosurgery. Neurosurg Focus. 2021 03; 50(3):E19. View in: Pubmed

    • Inhibitory CD161 receptor identified in glioma-infiltrating T cells by single-cell analysis. Cell. 2021 03 04; 184(5):1281-1298.e26. View in: Pubmed

    • Therapeutic cancer vaccines for pediatric malignancies: advances, challenges, and emerging technologies. Neurooncol Adv. 2021 Jan-Dec; 3(1):vdab027. View in: Pubmed

    • Targeting glioblastoma using a novel peptide specific to a deglycosylated isoform of brevican. Adv Ther (Weinh). 2021 Apr; 4(4). View in: Pubmed

    • The nuclear DICER-circular RNA complex drives the deregulation of the glioblastoma cell microRNAome. Sci Adv. 2020 12; 6(51). View in: Pubmed

    • HSV-1 Oncolytic Viruses from Bench to Bedside: An Overview of Current Clinical Trials. Cancers (Basel). 2020 Nov 26; 12(12). View in: Pubmed

    • Redesigned reporter gene for improved proton exchange-based molecular MRI contrast. Sci Rep. 2020 11 26; 10(1):20664. View in: Pubmed

    • Concurrent Dexamethasone Limits the Clinical Benefit of Immune Checkpoint Blockade in Glioblastoma. Clin Cancer Res. 2021 01 01; 27(1):276-287. View in: Pubmed

    • Oncolytic HSV Vectors and Anti-Tumor Immunity. Curr Issues Mol Biol. 2021; 41:381-468. View in: Pubmed

    • Glioblastoma in adults: a Society for Neuro-Oncology (SNO) and European Society of Neuro-Oncology (EANO) consensus review on current management and future directions. Neuro Oncol. 2020 08 17; 22(8):1073-1113. View in: Pubmed

    • Letter: Adaptation Under Fire: Two Harvard Neurosurgical Services During the COVID-19 Pandemic. Neurosurgery. 2020 08 01; 87(2):E173-E177. View in: Pubmed

    • National Institute of Neurological Disorders and Stroke: current funding status, opportunities, challenges, emerging scientific advances, and recommendations for neurosurgery. J Neurosurg. 2020 Jul 03; 1-6. View in: Pubmed

    • A Platinum(IV) Prodrug-Perfluoroaryl Macrocyclic Peptide Conjugate Enhances Platinum Uptake in the Brain. J Med Chem. 2020 07 09; 63(13):6741-6747. View in: Pubmed

    • Extracellular Vesicles Induce Mesenchymal Transition and Therapeutic Resistance in Glioblastomas through NF-?B/STAT3 Signaling. Adv Biosyst. 2020 12; 4(12):e1900312. View in: Pubmed

    • Tumor Interferon Signaling Is Regulated by a lncRNA INCR1 Transcribed from the PD-L1 Locus. Mol Cell. 2020 06 18; 78(6):1207-1223.e8. View in: Pubmed

    • Hypoxic Roadmap of Glioblastoma-Learning about Directions and Distances in the Brain Tumor Environment. Cancers (Basel). 2020 May 13; 12(5). View in: Pubmed

    • Immune Escape Mediated by Exosomal PD-L1 in Cancer. Adv Biosyst. 2020 12; 4(12):e2000017. View in: Pubmed

    • Editorial. COVID-19 and academic neurosurgery. J Neurosurg. 2020 Apr 17; 1-2. View in: Pubmed

    • Mechanisms and therapeutic implications of hypermutation in gliomas. Nature. 2020 04; 580(7804):517-523. View in: Pubmed

    • Cytomegalovirus Encephalopathy during Brain Tumor Irradiation. Clin Cancer Res. 2020 07 01; 26(13):3077-3078. View in: Pubmed

    • KLF4K409Q-mutated meningiomas show enhanced hypoxia signaling and respond to mTORC1 inhibitor treatment. Acta Neuropathol Commun. 2020 04 03; 8(1):41. View in: Pubmed

    • Preclinical Toxicology of rQNestin34.5v.2: An Oncolytic Herpes Virus with Transcriptional Regulation of the ICP34.5 Neurovirulence Gene. Mol Ther Methods Clin Dev. 2020 Jun 12; 17:871-893. View in: Pubmed

    • Glioblastoma infiltration of both tumor- and virus-antigen specific cytotoxic T cells correlates with experimental virotherapy responses. Sci Rep. 2020 03 20; 10(1):5095. View in: Pubmed

    • FASN Is a Biomarker Enriched in Malignant Glioma-Derived Extracellular Vesicles. Int J Mol Sci. 2020 Mar 12; 21(6). View in: Pubmed

    • Targeting glioma-initiating cells via the tyrosine metabolic pathway. J Neurosurg. 2020 Feb 14; 134(3):721-732. View in: Pubmed

    • Correction: Arming an Oncolytic Herpes Simplex Virus Type 1 with a Single-chain Fragment Variable Antibody against PD-1 for Experimental Glioblastoma Therapy. Clin Cancer Res. 2020 Feb 01; 26(3):758. View in: Pubmed

    • GBM-Targeted oHSV Armed with Matrix Metalloproteinase 9 Enhances Anti-tumor Activity and Animal Survival. Mol Ther Oncolytics. 2019 Dec 20; 15:214-222. View in: Pubmed

    • Letter: When Less is More: Dexamethasone Dosing for Brain Tumors. Neurosurgery. 2019 09 01; 85(3):E607-E608. View in: Pubmed

    • Regulatable interleukin-12 gene therapy in patients with recurrent high-grade glioma: Results of a phase 1 trial. Sci Transl Med. 2019 08 14; 11(505). View in: Pubmed

    • Characterization of single microvesicles in plasma from glioblastoma patients. Neuro Oncol. 2019 05 06; 21(5):606-615. View in: Pubmed

    • Proteomic Analysis Implicates Vimentin in Glioblastoma Cell Migration. Cancers (Basel). 2019 Apr 03; 11(4). View in: Pubmed

    • Radiation-Induced Targeted Nanoparticle-Based Gene Delivery for Brain Tumor Therapy. ACS Nano. 2019 04 23; 13(4):4028-4040. View in: Pubmed

    • Imaging flow cytometry facilitates multiparametric characterization of extracellular vesicles in malignant brain tumours. J Extracell Vesicles. 2019; 8(1):1588555. View in: Pubmed

    • Frameless Stereotactic Navigation during Insular Glioma Resection using Fusion of Three-Dimensional Rotational Angiography and Magnetic Resonance Imaging. World Neurosurg. 2019 Jun; 126:322-330. View in: Pubmed

    • Cytomegalovirus promotes murine glioblastoma growth via pericyte recruitment and angiogenesis. J Clin Invest. 2019 03 11; 129(4):1671-1683. View in: Pubmed

    • Molecular responses to immune checkpoint blockade in glioblastoma. Nat Med. 2019 03; 25(3):359-361. View in: Pubmed

    • Pneumatosis Intestinalis After Molecular-Targeted Therapy. World Neurosurg. 2019 05; 125:312-315. View in: Pubmed

    • The functional synergism of microRNA clustering provides therapeutically relevant epigenetic interference in glioblastoma. Nat Commun. 2019 01 25; 10(1):442. View in: Pubmed

    • Amendments: Publisher Correction: An oncolytic herpesvirus expressing E-cadherin improves survival in mouse models of glioblastoma. Nat Biotechnol. 2019 01 03; 37(1):102. View in: Pubmed

    • Viral and other therapies for recurrent glioblastoma: is a 24-month durable response unusual? Neuro Oncol. 2019 01 01; 21(1):14-25. View in: Pubmed

    • Neoantigen vaccine generates intratumoral T cell responses in phase Ib glioblastoma trial. Nature. 2019 01; 565(7738):234-239. View in: Pubmed

    • An oncolytic herpesvirus expressing E-cadherin improves survival in mouse models of glioblastoma. Nat Biotechnol. 2018 Nov 26. View in: Pubmed

    • Viruses in cancer therapy - from benchwarmers to quarterbacks. Nat Rev Clin Oncol. 2018 11; 15(11):657-658. View in: Pubmed

    • The multiple protective roles and molecular mechanisms of melatonin and its precursor N-acetylserotonin in targeting brain injury and liver damage and in maintaining bone health. Free Radic Biol Med. 2019 01; 130:215-233. View in: Pubmed

    • Arming an Oncolytic Herpes Simplex Virus Type 1 with a Single-chain Fragment Variable Antibody against PD-1 for Experimental Glioblastoma Therapy. Clin Cancer Res. 2019 01 01; 25(1):290-299. View in: Pubmed

    • A PDGFRa-driven mouse model of glioblastoma reveals a stathmin1-mediated mechanism of sensitivity to vinblastine. Nat Commun. 2018 08 06; 9(1):3116. View in: Pubmed

    • Immunotherapy for glioblastoma: going viral. Nat Med. 2018 08; 24(8):1094-1096. View in: Pubmed

    • Immune evasion mediated by PD-L1 on glioblastoma-derived extracellular vesicles. Sci Adv. 2018 03; 4(3):eaar2766. View in: Pubmed

    • Toxicity and Efficacy of a Novel GADD34-expressing Oncolytic HSV-1 for the Treatment of Experimental Glioblastoma. Clin Cancer Res. 2018 06 01; 24(11):2574-2584. View in: Pubmed

    • Endoscopic Endonasal Resection of a Suprasellar Pituitary Adenoma Mimicking Tuberculum Sellae Meningioma in a Patient with an Intrasellar Persistent Trigeminal Artery. J Neurol Surg B Skull Base. 2018 Apr; 79(Suppl 3):S285-S286. View in: Pubmed

    • Adult Tethered Cord Syndrome Following Chiari Decompression. World Neurosurg. 2018 Apr; 112:205-208. View in: Pubmed

    • Preclinical investigation of combined gene-mediated cytotoxic immunotherapy and immune checkpoint blockade in glioblastoma. Neuro Oncol. 2018 01 22; 20(2):225-235. View in: Pubmed

    • Modeling tumor immunity of mouse glioblastoma by exhausted CD8+ T cells. Sci Rep. 2018 01 09; 8(1):208. View in: Pubmed

    • Multiplexed Profiling of Single Extracellular Vesicles. ACS Nano. 2018 01 23; 12(1):494-503. View in: Pubmed

    • Oncolytic viruses sensitize human tumor cells for NY-ESO-1 tumor antigen recognition by CD4+ effector T cells. Oncoimmunology. 2018; 7(3):e1407897. View in: Pubmed

    • Anticancer activity of osmium(VI) nitrido complexes in patient-derived glioblastoma initiating cells and in vivo mouse models. Cancer Lett. 2018 03 01; 416:138-148. View in: Pubmed

    • Development of a Function-Blocking Antibody Against Fibulin-3 as a Targeted Reagent for Glioblastoma. Clin Cancer Res. 2018 02 15; 24(4):821-833. View in: Pubmed

    • Immunotherapy for glioblastoma: on the sidelines or in the game? Discov Med. 2017 11; 24(133):201-208. View in: Pubmed

    • Perfluoroarene-Based Peptide Macrocycles to Enhance Penetration Across the Blood-Brain Barrier. J Am Chem Soc. 2017 11 08; 139(44):15628-15631. View in: Pubmed

    • Detection of wild-type EGFR amplification and EGFRvIII mutation in CSF-derived extracellular vesicles of glioblastoma patients. Neuro Oncol. 2017 Oct 19; 19(11):1494-1502. View in: Pubmed

    • Salvage re-irradiation for recurrent high-grade glioma and comparison to bevacizumab alone. J Neurooncol. 2017 Dec; 135(3):581-591. View in: Pubmed

    • Human Cytomegalovirus is Present in Alveolar Soft Part Sarcoma. Appl Immunohistochem Mol Morphol. 2017 Oct; 25(9):615-619. View in: Pubmed

    • The Fc Domain of Immunoglobulin Is Sufficient to Bridge NK Cells with Virally Infected Cells. Immunity. 2017 07 18; 47(1):159-170.e10. View in: Pubmed

    • Blood-brain-barrier spheroids as an in vitro screening platform for brain-penetrating agents. Nat Commun. 2017 06 06; 8:15623. View in: Pubmed

    • MicroRNA-Mediated Dynamic Bidirectional Shift between the Subclasses of Glioblastoma Stem-like Cells. Cell Rep. 2017 06 06; 19(10):2026-2032. View in: Pubmed

    • Oncolytic Viruses in Cancer Treatment: A Review. JAMA Oncol. 2017 Jun 01; 3(6):841-849. View in: Pubmed

    • Dissecting inherent intratumor heterogeneity in patient-derived glioblastoma culture models. Neuro Oncol. 2017 06 01; 19(6):820-832. View in: Pubmed

    • MicroRNA Signatures and Molecular Subtypes of Glioblastoma: The Role of Extracellular Transfer. Stem Cell Reports. 2017 06 06; 8(6):1497-1505. View in: Pubmed

    • Launching Effectiveness Research to Guide Practice in Neurosurgery: A National Institute Neurological Disorders and Stroke Workshop Report. Neurosurgery. 2017 04 01; 80(4):505-514. View in: Pubmed

    • A Phase I Trial of Ad.hIFN-ß Gene Therapy for Glioma. Mol Ther. 2008 Mar; 16(3):618-626. View in: Pubmed

    • Tannous et al. Respond. Mol Ther. 2009 Aug; 17(8):1311-1312. View in: Pubmed

    • Frontal dermoid cyst coexisting with suprasellar craniopharyngioma: a spectrum of ectodermally derived epithelial-lined cystic lesions? Neurosurg Focus. 2016 12; 41(6):E16. View in: Pubmed

    • Glioma and microglia, a double entendre. Nat Immunol. 2016 10 19; 17(11):1240-1242. View in: Pubmed

    • Association between shunt-responsive idiopathic normal pressure hydrocephalus and alcohol. J Neurosurg. 2017 Aug; 127(2):240-248. View in: Pubmed

    • The Long Non-coding RNA HIF1A-AS2 Facilitates the Maintenance of Mesenchymal Glioblastoma Stem-like Cells in Hypoxic Niches. Cell Rep. 2016 06 14; 15(11):2500-9. View in: Pubmed

    • Design of a Microfluidic Chip for Magnetic-Activated Sorting of One-Bead-One-Compound Libraries. ACS Comb Sci. 2016 06 13; 18(6):271-8. View in: Pubmed

    • A combinational therapy of EGFR-CAR NK cells and oncolytic herpes simplex virus 1 for breast cancer brain metastases. Oncotarget. 2016 May 10; 7(19):27764-77. View in: Pubmed

    • Extracellular Vesicles from High-Grade Glioma Exchange Diverse Pro-oncogenic Signals That Maintain Intratumoral Heterogeneity. Cancer Res. 2016 05 15; 76(10):2876-81. View in: Pubmed

    • Extracellular Vesicles and MicroRNAs: Their Role in Tumorigenicity and Therapy for Brain Tumors. Cell Mol Neurobiol. 2016 Apr; 36(3):361-76. View in: Pubmed

    • Therapeutic potential of targeting microRNA-10b in established intracranial glioblastoma: first steps toward the clinic. EMBO Mol Med. 2016 Mar 01; 8(3):268-87. View in: Pubmed

    • BKM-120 (Buparlisib): A Phosphatidyl-Inositol-3 Kinase Inhibitor with Anti-Invasive Properties in Glioblastoma. Sci Rep. 2016 Feb 05; 6:20189. View in: Pubmed

    • Phase II multicenter study of gene-mediated cytotoxic immunotherapy as adjuvant to surgical resection for newly diagnosed malignant glioma. Neuro Oncol. 2016 08; 18(8):1137-45. View in: Pubmed

    • Current State of Immune-Based Therapies for Glioblastoma. Am Soc Clin Oncol Educ Book. 2016; 35:e132-9. View in: Pubmed

    • Experimental therapies: gene therapies and oncolytic viruses. Handb Clin Neurol. 2016; 134:183-97. View in: Pubmed

    • Cancer immunotherapy: A vaccine from plant virus proteins. Nat Nanotechnol. 2016 Mar; 11(3):214-5. View in: Pubmed

    • TGFß Treatment Enhances Glioblastoma Virotherapy by Inhibiting the Innate Immune Response. Cancer Res. 2015 Dec 15; 75(24):5273-82. View in: Pubmed

    • Awake Craniotomy and Intraoperative MRI for Maximal Safe Resection in a Case of an Extensive Left Frontal and Insular Low-grade Glioma: 3-Dimensional Operative Video. Oper Neurosurg (Hagerstown). 2015 Dec 01; 11(4):578. View in: Pubmed

    • Combining HDAC inhibitors with oncolytic virotherapy for cancer therapy. Oncolytic Virother. 2015; 4:183-91. View in: Pubmed

    • Reconstruction of Rare Skull Metastases Using Free Latissimus Dorsi Flap and the Role of Preoperative Embolization in Hypervascular Skull Tumors. J Craniofac Surg. 2015 Nov; 26(8):2289-92. View in: Pubmed

    • Histone deacetylase 6 inhibition enhances oncolytic viral replication in glioma. J Clin Invest. 2015 Nov 02; 125(11):4269-80. View in: Pubmed

    • Awake right hemisphere brain surgery. J Clin Neurosci. 2015 Dec; 22(12):1921-7. View in: Pubmed

    • Oncolytic Virus-Mediated Immunotherapy: A Combinatorial Approach for Cancer Treatment. J Clin Oncol. 2015 Sep 01; 33(25):2812-4. View in: Pubmed

    • In vitro screening of clinical drugs identifies sensitizers of oncolytic viral therapy in glioblastoma stem-like cells. Gene Ther. 2015 Dec; 22(12):947-59. View in: Pubmed

    • Response to energy depletion: miR-451/AMPK loop. Oncotarget. 2015 Jul 20; 6(20):17851-2. View in: Pubmed

    • CAR-Engineered NK Cells Targeting Wild-Type EGFR and EGFRvIII Enhance Killing of Glioblastoma and Patient-Derived Glioblastoma Stem Cells. Sci Rep. 2015 Jul 09; 5:11483. View in: Pubmed

    • Incidence, risk factors, and reasons for hospitalization among glioblastoma patients receiving chemoradiation. J Neurooncol. 2015 Aug; 124(1):137-46. View in: Pubmed

    • One size should not fit all: advancing toward personalized glioblastoma therapy. Discov Med. 2015 Jun; 19(107):471-7. View in: Pubmed

    • Extracranial growth of glioblastoma multiforme. J Clin Neurosci. 2015 Sep; 22(9):1521-3. View in: Pubmed

    • A cross-talk network that facilitates tumor virotherapy. Nat Med. 2015 May; 21(5):426-7. View in: Pubmed

    • Glucose-based regulation of miR-451/AMPK signaling depends on the OCT1 transcription factor. Cell Rep. 2015 May 12; 11(6):902-909. View in: Pubmed

    • Potentiating oncolytic viral therapy through an understanding of the initial immune responses to oncolytic viral infection. Curr Opin Virol. 2015 Aug; 13:25-32. View in: Pubmed

    • Hypofractionated versus standard radiation therapy with or without temozolomide for older glioblastoma patients. Int J Radiat Oncol Biol Phys. 2015 Jun 01; 92(2):384-9. View in: Pubmed

    • Modeling cytomegalovirus infection in mouse tumor models. Front Oncol. 2015; 5:61. View in: Pubmed

    • Clinical implementation of integrated whole-genome copy number and mutation profiling for glioblastoma. Neuro Oncol. 2015 Oct; 17(10):1344-55. View in: Pubmed

    • The Role of Radiation Therapy in Gross Totally Resected Meningiomas. World Neurosurg. 2015 Jul; 84(1):9-11. View in: Pubmed

    • MicroRNA-10b inhibition reduces E2F1-mediated transcription and miR-15/16 activity in glioblastoma. Oncotarget. 2015 Feb 28; 6(6):3770-83. View in: Pubmed

    • Editorial: the management of low-grade glioma in adults. Neurosurg Focus. 2015 Jan; 38(1):E8. View in: Pubmed

    • Introduction: a focus on low-grade glioma. Neurosurg Focus. 2015 Jan; 38(1):E2. View in: Pubmed

    • Superficial greater petrosal neuropathy. Neurol Clin Pract. 2014 Dec; 4(6):505-507. View in: Pubmed

    • Interferon-stimulated gene 15 (ISG15) and ISG15-linked proteins can associate with members of the selective autophagic process, histone deacetylase 6 (HDAC6) and SQSTM1/p62. J Biol Chem. 2015 Jan 16; 290(3):1485-95. View in: Pubmed

    • Belonging to a network--microRNAs, extracellular vesicles, and the glioblastoma microenvironment. Neuro Oncol. 2015 May; 17(5):652-62. View in: Pubmed

    • Predicting outcomes: recursive partitioning analysis (RPA) prognostic algorithm for patients with metastatic sarcoma to the brain. World Neurosurg. 2014 Dec; 82(6):1030-2. View in: Pubmed

    • Use of miRNA response sequences to block off-target replication and increase the safety of an unattenuated, glioblastoma-targeted oncolytic HSV. Mol Ther. 2015 Jan; 23(1):99-107. View in: Pubmed

    • Immunotherapy advances for glioblastoma. Neuro Oncol. 2014 Nov; 16(11):1441-58. View in: Pubmed

    • Skull base chordomas and chondrosarcomas: a population-based analysis. World Neurosurg. 2015 Apr; 83(4):468-70. View in: Pubmed

    • Evolution of malignant glioma treatment: from chemotherapy to vaccines to viruses. Neurosurgery. 2014 Aug; 61 Suppl 1:74-83. View in: Pubmed

    • Annexin A2 regulates angiogenesis and invasion phenotypes of malignant glioma. Neuro Oncol. 2014 Jul; 16 Suppl 3:iii10. View in: Pubmed

    • Cytomegalovirus contributes to glioblastoma in the context of tumor suppressor mutations. Neuro Oncol. 2014 Jul; 16 Suppl 3:iii8. View in: Pubmed

    • Low-grade gliomas and quality of life. World Neurosurg. 2014 Jul-Aug; 82(1-2):e133-4. View in: Pubmed

    • How much is enough? The question of extent of resection in glioblastoma multiforme. World Neurosurg. 2014 Jul-Aug; 82(1-2):e109-10. View in: Pubmed

    • Image-guided maximal resection of intrinsic tumors. World Neurosurg. 2014 Nov; 82(5):604-5. View in: Pubmed

    • Oncolytic viruses targeting tumor stem cells. Cancer Res. 2014 Jul 01; 74(13):3396-8. View in: Pubmed

    • Oncolytic viruses and their application to cancer immunotherapy. Cancer Immunol Res. 2014 Apr; 2(4):295-300. View in: Pubmed

    • Who benefits from surgery for brain metastases? World Neurosurg. 2014 Jul-Aug; 82(1-2):e115-6. View in: Pubmed

    • Phase 1 clinical trial of intratumoral reovirus infusion for the treatment of recurrent malignant gliomas in adults. Mol Ther. 2014 May; 22(5):1056-62. View in: Pubmed

    • No free lunch: secondary neoplasms after stereotactic radiation. World Neurosurg. 2015 Mar; 83(3):330-1. View in: Pubmed

    • Glioma virus therapies between bench and bedside. Neuro Oncol. 2014 Mar; 16(3):334-51. View in: Pubmed

    • Genetic validation of the protein arginine methyltransferase PRMT5 as a candidate therapeutic target in glioblastoma. Cancer Res. 2014 Mar 15; 74(6):1752-65. View in: Pubmed

    • Modification of HSV-1 to an oncolytic virus. Methods Mol Biol. 2014; 1144:117-27. View in: Pubmed

    • Extracellular vesicles modulate the glioblastoma microenvironment via a tumor suppression signaling network directed by miR-1. Cancer Res. 2014 Feb 01; 74(3):738-750. View in: Pubmed

    • Academic productivity in today's training climate: a fellowship's impact. World Neurosurg. 2015 Mar; 83(3):328-9. View in: Pubmed

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