Kai W. Wucherpfennig, MD, PhD

The CD58-CD2 axis is co-regulated with PD-L1 via CMTM6 and shapes anti-tumor immunity. Cancer Cell. 2023 07 10; 41(7):1207-1221.e12. View in: Pubmed

Injectable Oxygen Microparticles Boost Radiation-Mediated In Situ Vaccination and Systemic Antitumor Immune Responses. Int J Radiat Oncol Biol Phys. 2023 Jul 15; 116(4):906-915. View in: Pubmed

A chimeric antigen receptor uniquely recognizing MICA/B stress proteins provides an effective approach to target solid tumors. Med. 2023 Jul 14; 4(7):457-477.e8. View in: Pubmed

Addressing Tumor Heterogeneity by Sensitizing Resistant Cancer Cells to T cell-Secreted Cytokines. Cancer Discov. 2023 05 04; 13(5):1186-1209. View in: Pubmed

Systematic Interrogation of Tumor Cell Resistance to Chimeric Antigen Receptor T-cell Therapy in Pancreatic Cancer. Cancer Res. 2023 02 15; 83(4):613-625. View in: Pubmed

A structural platform for B cell receptor signaling. Cell Res. 2023 02; 33(2):95-96. View in: Pubmed

Cytokine conjugation to enhance T cell therapy. Proc Natl Acad Sci U S A. 2023 01 03; 120(1):e2213222120. View in: Pubmed

Breast cancer prevention by short-term inhibition of TGFß signaling. Nat Commun. 2022 12 07; 13(1):7558. View in: Pubmed

Designing Cancer Immunotherapies That Engage T Cells and NK Cells. Annu Rev Immunol. 2023 04 26; 41:17-38. View in: Pubmed

Oncometabolite d-2HG alters T cell metabolism to impair CD8+ T cell function. Science. 2022 09 30; 377(6614):1519-1529. View in: Pubmed

Mechanical checkpoint regulates monocyte differentiation in fibrotic niches. Nat Mater. 2022 08; 21(8):939-950. View in: Pubmed

Tissue-resident memory and circulating T cells are early responders to pre-surgical cancer immunotherapy. Cell. 2022 08 04; 185(16):2918-2935.e29. View in: Pubmed

A vaccine targeting resistant tumours by dual T cell plus NK cell attack. Nature. 2022 06; 606(7916):992-998. View in: Pubmed

MYC drives aggressive prostate cancer by disrupting transcriptional pause release at androgen receptor targets. Nat Commun. 2022 05 13; 13(1):2559. View in: Pubmed

A Conceptual Framework for Inducing T Cell-Mediated Immunity Against Glioblastoma. Semin Immunopathol. 2022 09; 44(5):697-707. View in: Pubmed

Augmenting NK cell-based immunotherapy by targeting mitochondrial apoptosis. Cell. 2022 04 28; 185(9):1521-1538.e18. View in: Pubmed

Quiescent cancer cells resist T cell attack by forming an immunosuppressive niche. Cell. 2022 05 12; 185(10):1694-1708.e19. View in: Pubmed

MICA/B-targeted antibody promotes NK cell-driven tumor immunity in patients with intrahepatic cholangiocarcinoma. Oncoimmunology. 2022; 11(1):2035919. View in: Pubmed

MICA/B antibody induces macrophage-mediated immunity against acute myeloid leukemia. Blood. 2022 01 13; 139(2):205-216. View in: Pubmed

Systematic investigation of cytokine signaling activity at the tissue and single-cell levels. Nat Methods. 2021 10; 18(10):1181-1191. View in: Pubmed

Interactions between cancer cells and immune cells drive transitions to mesenchymal-like states in glioblastoma. Cancer Cell. 2021 06 14; 39(6):779-792.e11. View in: Pubmed

cIAP1/2 antagonism eliminates MHC class I-negative tumors through T cell-dependent reprogramming of mononuclear phagocytes. Sci Transl Med. 2021 05 19; 13(594). View in: Pubmed

Inhibition of CDK4/6 Promotes CD8 T-cell Memory Formation. Cancer Discov. 2021 10; 11(10):2564-2581. View in: Pubmed

CARM1 Inhibition Enables Immunotherapy of Resistant Tumors by Dual Action on Tumor Cells and T Cells. Cancer Discov. 2021 08; 11(8):2050-2071. View in: Pubmed

Understanding and treating the inflammatory adverse events of cancer immunotherapy. Cell. 2021 03 18; 184(6):1575-1588. View in: Pubmed

Multimodal pooled Perturb-CITE-seq screens in patient models define mechanisms of cancer immune evasion. Nat Genet. 2021 03; 53(3):332-341. View in: Pubmed

Inhibitory CD161 receptor identified in glioma-infiltrating T cells by single-cell analysis. Cell. 2021 03 04; 184(5):1281-1298.e26. View in: Pubmed

Immunosuppressive Myeloid Cells Induce Nitric Oxide-Dependent DNA Damage and p53 Pathway Activation in CD8+ T Cells. Cancer Immunol Res. 2021 04; 9(4):470-485. View in: Pubmed

Opposing immune and genetic mechanisms shape oncogenic programs in synovial sarcoma. Nat Med. 2021 02; 27(2):289-300. View in: Pubmed

Personal neoantigen vaccines induce persistent memory T cell responses and epitope spreading in patients with melanoma. Nat Med. 2021 03; 27(3):515-525. View in: Pubmed

Integrin avß6-TGFß-SOX4 Pathway Drives Immune Evasion in Triple-Negative Breast Cancer. Cancer Cell. 2021 01 11; 39(1):54-67.e9. View in: Pubmed

Mechanism of EBV inducing anti-tumour immunity and its therapeutic use. Nature. 2021 02; 590(7844):157-162. View in: Pubmed

Neoadjuvant Nivolumab or Nivolumab Plus Ipilimumab in Untreated Oral Cavity Squamous Cell Carcinoma: A Phase 2 Open-Label Randomized Clinical Trial. JAMA Oncol. 2020 10 01; 6(10):1563-1570. View in: Pubmed

Inhibition of MAN2A1 Enhances the Immune Response to Anti-PD-L1 in Human Tumors. Clin Cancer Res. 2020 11 15; 26(22):5990-6002. View in: Pubmed

Single-Cell RNA-Seq Reveals Cellular Hierarchies and Impaired Developmental Trajectories in Pediatric Ependymoma. Cancer Cell. 2020 07 13; 38(1):44-59.e9. View in: Pubmed

Correction: Hdac3 is an epigenetic inhibitor of the cytotoxicity program in CD8 T cells. J Exp Med. 2020 07 06; 217(7). View in: Pubmed

Hdac3 is an epigenetic inhibitor of the cytotoxicity program in CD8 T cells. J Exp Med. 2020 07 06; 217(7). View in: Pubmed

Molecular Pathways of Colon Inflammation Induced by Cancer Immunotherapy. Cell. 2020 08 06; 182(3):655-671.e22. View in: Pubmed

Metabolic labeling and targeted modulation of dendritic cells. Nat Mater. 2020 11; 19(11):1244-1252. View in: Pubmed

Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer. Mol Cell. 2020 06 18; 78(6):1096-1113.e8. View in: Pubmed

Acquired resistance to combined BET and CDK4/6 inhibition in triple-negative breast cancer. Nat Commun. 2020 05 11; 11(1):2350. View in: Pubmed

Inhibition of MICA and MICB Shedding Elicits NK-Cell-Mediated Immunity against Tumors Resistant to Cytotoxic T Cells. Cancer Immunol Res. 2020 06; 8(6):769-780. View in: Pubmed

Distinct Mesenchymal Cell Populations Generate the Essential Intestinal BMP Signaling Gradient. Cell Stem Cell. 2020 03 05; 26(3):391-402.e5. View in: Pubmed

Ascl2-Dependent Cell Dedifferentiation Drives Regeneration of Ablated Intestinal Stem Cells. Cell Stem Cell. 2020 03 05; 26(3):377-390.e6. View in: Pubmed

Replicational Dilution of H3K27me3 in Mammalian Cells and the Role of Poised Promoters. Mol Cell. 2020 04 02; 78(1):141-151.e5. View in: Pubmed

Inhibition of Haspin Kinase Promotes Cell-Intrinsic and Extrinsic Antitumor Activity. Cancer Res. 2020 02 15; 80(4):798-810. View in: Pubmed

Discovery of specialized NK cell populations infiltrating human melanoma metastases. JCI Insight. 2019 12 05; 4(23). View in: Pubmed

MHC-II neoantigens shape tumour immunity and response to immunotherapy. Nature. 2019 10; 574(7780):696-701. View in: Pubmed

T-Scan: A Genome-wide Method for the Systematic Discovery of T Cell Epitopes. Cell. 2019 08 08; 178(4):1016-1028.e13. View in: Pubmed

Subclonal cooperation drives metastasis by modulating local and systemic immune microenvironments. Nat Cell Biol. 2019 07; 21(7):879-888. View in: Pubmed

Publisher Correction: Landscape of B cell immunity and related immune evasion in human cancers. Nat Genet. 2019 Jun; 51(6):1068. View in: Pubmed

Visualization and quantification of NK cell-mediated cytotoxicity over extended time periods by image cytometry. J Immunol Methods. 2019 06; 469:47-51. View in: Pubmed

Epithelial endoplasmic reticulum stress orchestrates a protective IgA response. Science. 2019 03 01; 363(6430):993-998. View in: Pubmed

Landscape of B cell immunity and related immune evasion in human cancers. Nat Genet. 2019 03; 51(3):560-567. View in: Pubmed

Neoantigen vaccine generates intratumoral T cell responses in phase Ib glioblastoma trial. Nature. 2019 01; 565(7738):234-239. View in: Pubmed

Radiotherapy induces responses of lung cancer to CTLA-4 blockade. Nat Med. 2018 12; 24(12):1845-1851. View in: Pubmed

A Cancer Cell Program Promotes T Cell Exclusion and Resistance to Checkpoint Blockade. Cell. 2018 11 01; 175(4):984-997.e24. View in: Pubmed

FAP Delineates Heterogeneous and Functionally Divergent Stromal Cells in Immune-Excluded Breast Tumors. Cancer Immunol Res. 2018 12; 6(12):1472-1485. View in: Pubmed

Rapid CLIP dissociation from MHC II promotes an unusual antigen presentation pathway in autoimmunity. J Exp Med. 2018 10 01; 215(10):2617-2635. View in: Pubmed

Signatures of T cell dysfunction and exclusion predict cancer immunotherapy response. Nat Med. 2018 10; 24(10):1550-1558. View in: Pubmed

Engineered MBP-specific human Tregs ameliorate MOG-induced EAE through IL-2-triggered inhibition of effector T cells. J Autoimmun. 2018 08; 92:77-86. View in: Pubmed

Vaccine-elicited receptor-binding site antibodies neutralize two New World hemorrhagic fever arenaviruses. Nat Commun. 2018 05 14; 9(1):1884. View in: Pubmed

Developmental and oncogenic programs in H3K27M gliomas dissected by single-cell RNA-seq. Science. 2018 04 20; 360(6386):331-335. View in: Pubmed

Antibody-mediated inhibition of MICA and MICB shedding promotes NK cell-driven tumor immunity. Science. 2018 Mar 30; 359(6383):1537-1542. View in: Pubmed

Corrigendum: An immunogenic personal neoantigen vaccine for patients with melanoma. Nature. 2018 03 14; 555(7696):402. View in: Pubmed

A facile approach to enhance antigen response for personalized cancer vaccination. Nat Mater. 2018 06; 17(6):528-534. View in: Pubmed

Signaling by the Epstein-Barr virus LMP1 protein induces potent cytotoxic CD4+ and CD8+ T cell responses. Proc Natl Acad Sci U S A. 2018 01 23; 115(4):E686-E695. View in: Pubmed

A major chromatin regulator determines resistance of tumor cells to T cell-mediated killing. Science. 2018 02 16; 359(6377):770-775. View in: Pubmed

T cell-targeting nanoparticles focus delivery of immunotherapy to improve antitumor immunity. Nat Commun. 2017 11 23; 8(1):1747. View in: Pubmed

Immunotherapy for glioblastoma: on the sidelines or in the game? Discov Med. 2017 11; 24(133):201-208. View in: Pubmed

Erratum: The microRNA miR-31 inhibits CD8+ T cell function in chronic viral infection. Nat Immunol. 2017 09 19; 18(10):1173. View in: Pubmed

Immunomodulation for glioblastoma. Curr Opin Neurol. 2017 06; 30(3):361-369. View in: Pubmed

The microRNA miR-31 inhibits CD8+ T cell function in chronic viral infection. Nat Immunol. 2017 Jul; 18(7):791-799. View in: Pubmed

Noninvasive Imaging of Human Immune Responses in a Human Xenograft Model of Graft-Versus-Host Disease. J Nucl Med. 2017 06; 58(6):1003-1008. View in: Pubmed

Multicomponent Injectable Hydrogels for Antigen-Specific Tolerogenic Immune Modulation. Adv Healthc Mater. 2017 Mar; 6(6). View in: Pubmed

Studying Dynamic Plasma Membrane Binding of TCR-CD3 Chains During Immunological Synapse Formation Using Donor-Quenching FRET and FLIM-FRET. Methods Mol Biol. 2017; 1584:259-289. View in: Pubmed

Cytotoxic T Cells in PD-L1-Positive Malignant Pleural Mesotheliomas Are Counterbalanced by Distinct Immunosuppressive Factors. Cancer Immunol Res. 2016 12; 4(12):1038-1048. View in: Pubmed

Binding of the cytoplasmic domain of CD28 to the plasma membrane inhibits Lck recruitment and signaling. Sci Signal. 2016 07 26; 9(438):ra75. View in: Pubmed

Genetic screens to study the immune system in cancer. Curr Opin Immunol. 2016 08; 41:55-61. View in: Pubmed

Clinical and MRI phenotype of children with MOG antibodies. Mult Scler. 2016 Feb; 22(2):174-84. View in: Pubmed

Molecular mechanisms for contribution of MHC molecules to autoimmune diseases. Curr Opin Immunol. 2014 Dec; 31:24-30. View in: Pubmed

Immunotherapy advances for glioblastoma. Neuro Oncol. 2014 Nov; 16(11):1441-58. View in: Pubmed

B cell homeostasis and follicle confines are governed by fibroblastic reticular cells. Nat Immunol. 2014 Oct; 15(10):973-81. View in: Pubmed

Membrane association of the CD3e signaling domain is required for optimal T cell development and function. J Immunol. 2014 Jul 01; 193(1):258-67. View in: Pubmed

Abnormal B cell memory subsets dominate HIV-specific responses in infected individuals. J Clin Invest. 2014 Jul; 124(7):3252-62. View in: Pubmed

Deconstructing the peptide-MHC specificity of T cell recognition. Cell. 2014 May 22; 157(5):1073-87. View in: Pubmed

Discovering cancer immunotherapy targets in vivo. Oncoimmunology. 2014; 3:e28500. View in: Pubmed

The tumor microenvironment shapes lineage, transcriptional, and functional diversity of infiltrating myeloid cells. Cancer Immunol Res. 2014 Jul; 2(7):655-67. View in: Pubmed

Polarized release of T-cell-receptor-enriched microvesicles at the immunological synapse. Nature. 2014 Mar 06; 507(7490):118-23. View in: Pubmed

In vivo discovery of immunotherapy targets in the tumour microenvironment. Nature. 2014 Feb 06; 506(7486):52-7. View in: Pubmed

Mechanisms of peptide repertoire selection by HLA-DM. Trends Immunol. 2013 Oct; 34(10):495-501. View in: Pubmed

Cracking the code of human T-cell immunity. Nat Biotechnol. 2013 Jul; 31(7):609-10. View in: Pubmed

An update on vaccine therapy and other immunotherapeutic approaches for glioblastoma. Expert Rev Vaccines. 2013 Jun; 12(6):597-615. View in: Pubmed

Crossreactivity of a human autoimmune TCR is dominated by a single TCR loop. Nat Commun. 2013; 4:2623. View in: Pubmed

Crystal structure of the HLA-DM-HLA-DR1 complex defines mechanisms for rapid peptide selection. Cell. 2012 Dec 21; 151(7):1557-68. View in: Pubmed

Local changes in lipid environment of TCR microclusters regulate membrane binding by the CD3e cytoplasmic domain. J Exp Med. 2012 Dec 17; 209(13):2423-39. View in: Pubmed

Identification of HIV-1-specific regulatory T-cells using HLA class II tetramers. AIDS. 2012 Oct 23; 26(16):2112-5. View in: Pubmed

Functional single-cell analysis of T-cell activation by supported lipid bilayer-tethered ligands on arrays of nanowells. Lab Chip. 2013 Jan 07; 13(1):90-9. View in: Pubmed

Alternative RISC assembly: binding and repression of microRNA-mRNA duplexes by human Ago proteins. RNA. 2012 Nov; 18(11):2041-55. View in: Pubmed

Podoplanin-rich stromal networks induce dendritic cell motility via activation of the C-type lectin receptor CLEC-2. Immunity. 2012 Aug 24; 37(2):276-89. View in: Pubmed

Self-reactive human CD4 T cell clones form unusual immunological synapses. J Exp Med. 2012 Feb 13; 209(2):335-52. View in: Pubmed

Th17 cells induce ectopic lymphoid follicles in central nervous system tissue inflammation. Immunity. 2011 Dec 23; 35(6):986-96. View in: Pubmed

The mechanism of HLA-DM induced peptide exchange in the MHC class II antigen presentation pathway. Curr Opin Immunol. 2012 Feb; 24(1):105-11. View in: Pubmed

Autoimmune diseases have been the focus of intense research efforts. Curr Opin Immunol. 2011 Dec; 23(6):699-701. View in: Pubmed

Cell surface display of functional human MHC class II proteins: yeast display versus insect cell display. Protein Eng Des Sel. 2011 Sep; 24(9):701-9. View in: Pubmed

Ex vivo characterization and isolation of rare memory B cells with antigen tetramers. Blood. 2011 Jul 14; 118(2):348-57. View in: Pubmed

T cell receptor recognition of self and foreign antigens in the induction of autoimmunity. Semin Immunol. 2011 Apr; 23(2):84-91. View in: Pubmed

Impaired thymic tolerance to a-myosin directs autoimmunity to the heart in mice and humans. J Clin Invest. 2011 Apr; 121(4):1561-73. View in: Pubmed

MicroRNA expression profiling identifies activated B cell status in chronic lymphocytic leukemia cells. PLoS One. 2011 Mar 08; 6(3):e16956. View in: Pubmed

A highly tilted binding mode by a self-reactive T cell receptor results in altered engagement of peptide and MHC. J Exp Med. 2011 Jan 17; 208(1):91-102. View in: Pubmed

HLA-DM captures partially empty HLA-DR molecules for catalyzed removal of peptide. Nat Immunol. 2011 Jan; 12(1):54-61. View in: Pubmed

The first structures of T cell receptors bound to peptide-MHC. J Immunol. 2010 Dec 01; 185(11):6391-3. View in: Pubmed

The structural basis for intramembrane assembly of an activating immunoreceptor complex. Nat Immunol. 2010 Nov; 11(11):1023-9. View in: Pubmed

Response multilayered control of T cell receptor phosphorylation. Cell. 2010 Sep 03; 142(5):669-71. View in: Pubmed

Targeted regulation of self-peptide presentation prevents type I diabetes in mice without disrupting general immunocompetence. J Clin Invest. 2010 Apr; 120(4):1324-36. View in: Pubmed

Structural biology of the T-cell receptor: insights into receptor assembly, ligand recognition, and initiation of signaling. Cold Spring Harb Perspect Biol. 2010 Apr; 2(4):a005140. View in: Pubmed

Positively selecting peptides: their job does not end in the thymus. Nat Immunol. 2009 Nov; 10(11):1143-4. View in: Pubmed

Structural alterations in peptide-MHC recognition by self-reactive T cell receptors. Curr Opin Immunol. 2009 Dec; 21(6):590-5. View in: Pubmed

Age-dependent B cell autoimmunity to a myelin surface antigen in pediatric multiple sclerosis. J Immunol. 2009 Sep 15; 183(6):4067-76. View in: Pubmed

In vivo enhancement of peptide display by MHC class II molecules with small molecule catalysts of peptide exchange. J Immunol. 2009 May 15; 182(10):6342-52. View in: Pubmed

Suppression of autoimmune diabetes by soluble galectin-1. J Immunol. 2009 Mar 01; 182(5):2641-53. View in: Pubmed

Regulation of T cell receptor activation by dynamic membrane binding of the CD3epsilon cytoplasmic tyrosine-based motif. Cell. 2008 Nov 14; 135(4):702-13. View in: Pubmed

Variable patterns of programmed death-1 expression on fully functional memory T cells after spontaneous resolution of hepatitis C virus infection. J Virol. 2008 May; 82(10):5109-14. View in: Pubmed

Induction of antigen-specific regulatory T cells in wild-type mice: visualization and targets of suppression. Proc Natl Acad Sci U S A. 2008 Mar 04; 105(9):3479-84. View in: Pubmed

B cells and autoantibodies in the pathogenesis of multiple sclerosis and related inflammatory demyelinating diseases. Adv Immunol. 2008; 98:121-49. View in: Pubmed

Ex vivo analysis of human T lymphotropic virus type 1-specific CD4+ cells by use of a major histocompatibility complex class II tetramer composed of a neurological disease-susceptibility allele and its immunodominant peptide. J Infect Dis. 2007 Dec 15; 196(12):1761-72. View in: Pubmed

Common themes in the assembly and architecture of activating immune receptors. Nat Rev Immunol. 2007 Nov; 7(11):841-50. View in: Pubmed

Empty class II major histocompatibility complex created by peptide photolysis establishes the role of DM in peptide association. J Biol Chem. 2007 Jul 20; 282(29):21425-36. View in: Pubmed

Dominant-negative effect of the heterozygous C104R TACI mutation in common variable immunodeficiency (CVID). J Clin Invest. 2007 Jun; 117(6):1550-7. View in: Pubmed

Regulation of activated CD4+ T cells by NK cells via the Qa-1-NKG2A inhibitory pathway. Immunity. 2007 May; 26(5):593-604. View in: Pubmed

Polyspecificity of T cell and B cell receptor recognition. Semin Immunol. 2007 Aug; 19(4):216-24. View in: Pubmed

Myelin-specific regulatory T cells accumulate in the CNS but fail to control autoimmune inflammation. Nat Med. 2007 Apr; 13(4):423-31. View in: Pubmed

Structural basis of T-cell specificity and activation by the bacterial superantigen TSST-1. EMBO J. 2007 Feb 21; 26(4):1187-97. View in: Pubmed

Self-antigen tetramers discriminate between myelin autoantibodies to native or denatured protein. Nat Med. 2007 Feb; 13(2):211-7. View in: Pubmed

The structure of the zetazeta transmembrane dimer reveals features essential for its assembly with the T cell receptor. Cell. 2006 Oct 20; 127(2):355-68. View in: Pubmed

A membrane-proximal tetracysteine motif contributes to assembly of CD3deltaepsilon and CD3gammaepsilon dimers with the T cell receptor. J Biol Chem. 2006 Dec 01; 281(48):36977-84. View in: Pubmed

Transient immunological control during acute hepatitis C virus infection: ex vivo analysis of helper T-cell responses. J Viral Hepat. 2006 Oct; 13(10):708-14. View in: Pubmed

The assembly of diverse immune receptors is focused on a polar membrane-embedded interaction site. PLoS Biol. 2006 May; 4(5):e142. View in: Pubmed

Small molecules that enhance the catalytic efficiency of HLA-DM. J Immunol. 2006 Apr 01; 176(7):4208-20. View in: Pubmed

Expansion and contraction of HIV-specific CD4 T cells with short bursts of viremia, but physical loss of the majority of these cells with sustained viral replication. J Immunol. 2005 Nov 15; 175(10):6948-58. View in: Pubmed

Cutting edge: CD4+CD25+ regulatory T cells contribute to gender differences in susceptibility to experimental autoimmune encephalomyelitis. J Immunol. 2005 Nov 01; 175(9):5591-5. View in: Pubmed

Unusual features of self-peptide/MHC binding by autoimmune T cell receptors. Immunity. 2005 Oct; 23(4):351-60. View in: Pubmed

Antibodies from inflamed central nervous system tissue recognize myelin oligodendrocyte glycoprotein. J Immunol. 2005 Aug 01; 175(3):1974-82. View in: Pubmed

The activating NKG2D receptor assembles in the membrane with two signaling dimers into a hexameric structure. Proc Natl Acad Sci U S A. 2005 May 24; 102(21):7641-6. View in: Pubmed

Unconventional topology of self peptide-major histocompatibility complex binding by a human autoimmune T cell receptor. Nat Immunol. 2005 May; 6(5):490-6. View in: Pubmed

Convergence on a distinctive assembly mechanism by unrelated families of activating immune receptors. Immunity. 2005 Apr; 22(4):427-38. View in: Pubmed

The structural interactions between T cell receptors and MHC-peptide complexes place physical limits on self-nonself discrimination. Curr Top Microbiol Immunol. 2005; 296:19-37. View in: Pubmed

The T cell receptor: critical role of the membrane environment in receptor assembly and function. Annu Rev Immunol. 2005; 23:101-25. View in: Pubmed

The solvent-inaccessible Cys67 residue of HLA-B27 contributes to T cell recognition of HLA-B27/peptide complexes. J Immunol. 2004 Dec 01; 173(11):6564-73. View in: Pubmed

Measuring T cell immunity to influenza vaccination in children after haemopoietic stem cell transplantation. Br J Haematol. 2004 Nov; 127(3):322-5. View in: Pubmed

Myelin proteolipid protein-specific CD4+CD25+ regulatory cells mediate genetic resistance to experimental autoimmune encephalomyelitis. Proc Natl Acad Sci U S A. 2004 Oct 26; 101(43):15434-9. View in: Pubmed

Self-peptides that bind with low affinity to the diabetes-associated I-A(g7) molecule readily induce T cell tolerance in non-obese diabetic mice. Eur J Immunol. 2004 Oct; 34(10):2656-63. View in: Pubmed

Prevention of type 1 diabetes by gene therapy. J Clin Invest. 2004 Oct; 114(7):969-78. View in: Pubmed

Cross-reactive TCR responses to self antigens presented by different MHC class II molecules. J Immunol. 2004 Aug 01; 173(3):1689-98. View in: Pubmed

Expression of the B7.1 costimulatory molecule on pancreatic beta cells abrogates the requirement for CD4 T cells in the development of type 1 diabetes. J Immunol. 2004 Jul 15; 173(2):787-96. View in: Pubmed

Stoichiometry of the T-cell receptor-CD3 complex and key intermediates assembled in the endoplasmic reticulum. EMBO J. 2004 Jun 16; 23(12):2348-57. View in: Pubmed

Suppression of autoimmune disease after vaccination with autoreactive T cells that express Qa-1 peptide complexes. J Clin Invest. 2004 Apr; 113(8):1218-24. View in: Pubmed

Molecular mechanisms for the assembly of the T cell receptor-CD3 complex. Mol Immunol. 2004 Apr; 40(18):1295-305. View in: Pubmed

A spontaneous model for autoimmune myocarditis using the human MHC molecule HLA-DQ8. J Immunol. 2004 Feb 15; 172(4):2651-8. View in: Pubmed

T cell receptor crossreactivity as a general property of T cell recognition. Mol Immunol. 2004 Feb; 40(14-15):1009-17. View in: Pubmed

Presentation of a self-peptide in two distinct conformations by a disease-associated HLA-B27 subtype. J Exp Med. 2004 Jan 19; 199(2):151-4. View in: Pubmed

Detailed analysis of the effects of Glu/Lys beta69 human leukocyte antigen-DP polymorphism on peptide-binding specificity. Tissue Antigens. 2003 Dec; 62(6):459-71. View in: Pubmed

MHC-linked susceptibility to type 1 diabetes: a structural perspective. Ann N Y Acad Sci. 2003 Nov; 1005:119-27. View in: Pubmed

Ex vivo analysis of thymic CD4 T cells in nonobese diabetic mice with tetramers generated from I-A(g7)/class II-associated invariant chain peptide precursors. J Immunol. 2003 Oct 15; 171(8):4175-86. View in: Pubmed

Ex vivo analysis of human memory CD4 T cells specific for hepatitis C virus using MHC class II tetramers. J Clin Invest. 2003 Sep; 112(6):831-42. View in: Pubmed

The shared tumor-associated antigen cytochrome P450 1B1 is recognized by specific cytotoxic T cells. Blood. 2003 Nov 01; 102(9):3287-94. View in: Pubmed

Myelin basic protein-reactive autoantibodies in the serum and cerebrospinal fluid of multiple sclerosis patients are characterized by low-affinity interactions. J Neuroimmunol. 2003 Mar; 136(1-2):140-8. View in: Pubmed

Detection of autoreactive myelin proteolipid protein 139-151-specific T cells by using MHC II (IAs) tetramers. J Immunol. 2003 Jan 15; 170(2):870-7. View in: Pubmed

The organizing principle in the formation of the T cell receptor-CD3 complex. Cell. 2002 Dec 27; 111(7):967-79. View in: Pubmed

Structural factors contributing to DM susceptibility of MHC class II/peptide complexes. J Immunol. 2002 Nov 01; 169(9):5109-17. View in: Pubmed

A functional and structural basis for TCR cross-reactivity in multiple sclerosis. Nat Immunol. 2002 Oct; 3(10):940-3. View in: Pubmed

Infectious triggers for inflammatory neurological diseases. Nat Med. 2002 May; 8(5):455-7. View in: Pubmed

Human primary and memory cytotoxic T lymphocyte responses are efficiently induced by means of CD40-activated B cells as antigen-presenting cells: potential for clinical application. Blood. 2002 May 01; 99(9):3319-25. View in: Pubmed

Insights into autoimmunity gained from structural analysis of MHC-peptide complexes. Curr Opin Immunol. 2001 Dec; 13(6):650-6. View in: Pubmed

Equivalent induction of telomerase-specific cytotoxic T lymphocytes from tumor-bearing patients and healthy individuals. Cancer Res. 2001 Dec 01; 61(23):8366-70. View in: Pubmed

Mechanisms for the induction of autoimmunity by infectious agents. J Clin Invest. 2001 Oct; 108(8):1097-104. View in: Pubmed

Conserved CDR3 regions in T-cell receptor (TCR) CD8(+) T cells that recognize the Tax11-19/HLA-A*0201 complex in a subject infected with human T-cell leukemia virus type 1: relationship of T-cell fine specificity and major histocompatibility complex/peptide/TCR crystal structure. J Virol. 2001 Oct; 75(20):9836-43. View in: Pubmed

Type 1 diabetes. Nat Immunol. 2001 Sep; 2(9):767-8. View in: Pubmed

Analysis of the relationship between viral infection and autoimmune disease. Immunity. 2001 Jul; 15(1):137-47. View in: Pubmed

Structure of a human insulin peptide-HLA-DQ8 complex and susceptibility to type 1 diabetes. Nat Immunol. 2001 Jun; 2(6):501-7. View in: Pubmed

Structural basis of molecular mimicry. J Autoimmun. 2001 May; 16(3):293-302. View in: Pubmed

Anergy induction by dimeric TCR ligands. J Immunol. 2001 Apr 15; 166(8):5279-85. View in: Pubmed

Selective activation and expansion of high-affinity CD4+ T cells in resistant mice upon infection with Leishmania major. Immunity. 2000 Dec; 13(6):771-82. View in: Pubmed

Binding of conserved islet peptides by human and murine MHC class II molecules associated with susceptibility to type I diabetes. Eur J Immunol. 2000 Sep; 30(9):2497-506. View in: Pubmed

Visualization of myelin basic protein (MBP) T cell epitopes in multiple sclerosis lesions using a monoclonal antibody specific for the human histocompatibility leukocyte antigen (HLA)-DR2-MBP 85-99 complex. J Exp Med. 2000 Apr 17; 191(8):1395-412. View in: Pubmed

Kinetics of T-cell receptor binding by bivalent HLA-DR. Peptide complexes that activate antigen-specific human T-cells. J Biol Chem. 2000 Jan 07; 275(1):312-21. View in: Pubmed

A humanized model for multiple sclerosis using HLA-DR2 and a human T-cell receptor. Nat Genet. 1999 Nov; 23(3):343-7. View in: Pubmed

pH-dependent peptide binding properties of the type I diabetes-associated I-Ag7 molecule: rapid release of CLIP at an endosomal pH. J Exp Med. 1999 Jun 07; 189(11):1723-34. View in: Pubmed

Peptide recognition by two HLA-A2/Tax11-19-specific T cell clones in relationship to their MHC/peptide/TCR crystal structures. J Immunol. 1999 May 01; 162(9):5389-97. View in: Pubmed

Binding motifs of copolymer 1 to multiple sclerosis- and rheumatoid arthritis-associated HLA-DR molecules. J Immunol. 1999 Apr 15; 162(8):4697-704. View in: Pubmed

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Crystal structure of HLA-DR2 (DRA*0101, DRB1*1501) complexed with a peptide from human myelin basic protein. J Exp Med. 1998 Oct 19; 188(8):1511-20. View in: Pubmed

Expression and crystallization of the complex of HLA-DR2 (DRA, DRB1*1501) and an immunodominant peptide of human myelin basic protein. Proc Natl Acad Sci U S A. 1998 Sep 29; 95(20):11828-33. View in: Pubmed

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Microbial peptides and superantigens in the pathogenesis of autoimmune diseases of the central nervous system. Semin Immunol. 1998 Feb; 10(1):57-67. View in: Pubmed

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Tolerance induction to myelin basic protein by intravenous synthetic peptides containing epitope P85 VVHFFKNIVTP96 in chronic progressive multiple sclerosis. J Neurol Sci. 1997 Nov 06; 152(1):31-8. View in: Pubmed

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Expression of recombinant HLA-DR2 molecules. Replacement of the hydrophobic transmembrane region by a leucine zipper dimerization motif allows the assembly and secretion of soluble DR alpha beta heterodimers. J Biol Chem. 1996 Aug 16; 271(33):20156-62. View in: Pubmed

Structural basis for major histocompatibility complex (MHC)-linked susceptibility to autoimmunity: charged residues of a single MHC binding pocket confer selective presentation of self-peptides in pemphigus vulgaris. Proc Natl Acad Sci U S A. 1995 Dec 05; 92(25):11935-9. View in: Pubmed

Structure of human T-cell receptors specific for an immunodominant myelin basic protein peptide: positioning of T-cell receptors on HLA-DR2/peptide complexes. Proc Natl Acad Sci U S A. 1995 Sep 12; 92(19):8896-900. View in: Pubmed

A review of T-cell receptors in multiple sclerosis: clonal expansion and persistence of human T-cells specific for an immunodominant myelin basic protein peptide. Ann N Y Acad Sci. 1995 Jul 07; 756:241-58. View in: Pubmed

Selective binding of self peptides to disease-associated major histocompatibility complex (MHC) molecules: a mechanism for MHC-linked susceptibility to human autoimmune diseases. J Exp Med. 1995 May 01; 181(5):1597-601. View in: Pubmed

Molecular mimicry in T cell-mediated autoimmunity: viral peptides activate human T cell clones specific for myelin basic protein. Cell. 1995 Mar 10; 80(5):695-705. View in: Pubmed

Functional three-domain single-chain T-cell receptors. Proc Natl Acad Sci U S A. 1994 Dec 20; 91(26):12654-8. View in: Pubmed

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Structural requirements for binding of an immunodominant myelin basic protein peptide to DR2 isotypes and for its recognition by human T cell clones. J Exp Med. 1994 Jan 01; 179(1):279-90. View in: Pubmed

Human fetal liver gamma/delta T cells predominantly use unusual rearrangements of the T cell receptor delta and gamma loci expressed on both CD4+CD8- and CD4-CD8- gamma/delta T cells. J Exp Med. 1993 Feb 01; 177(2):425-32. View in: Pubmed

Characterization of HTLV-I in vivo infected T cell clones. IL-2-independent growth of nontransformed T cells. J Immunol. 1992 May 15; 148(10):3256-63. View in: Pubmed

Gamma delta T-cell receptor repertoire in acute multiple sclerosis lesions. Proc Natl Acad Sci U S A. 1992 May 15; 89(10):4588-92. View in: Pubmed

T cell receptor V alpha-V beta repertoire and cytokine gene expression in active multiple sclerosis lesions. J Exp Med. 1992 Apr 01; 175(4):993-1002. View in: Pubmed

T-cell activation by autologous human T-cell leukemia virus type I-infected T-cell clones. Proc Natl Acad Sci U S A. 1992 Mar 15; 89(6):2110-4. View in: Pubmed

The potential of restricted T cell recognition of myelin basic protein epitopes in the therapy of multiple sclerosis. Ann N Y Acad Sci. 1991 Dec 30; 636:251-65. View in: Pubmed

Oligoclonal expansion and CD1 recognition by human intestinal intraepithelial lymphocytes. Science. 1991 Sep 20; 253(5026):1411-5. View in: Pubmed

T-cell recognition of myelin basic protein. Immunol Today. 1991 Aug; 12(8):277-82. View in: Pubmed

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Common T-cell receptor V beta usage in oligoclonal T lymphocytes derived from cerebrospinal fluid and blood of patients with multiple sclerosis. Ann Neurol. 1991 Jan; 29(1):33-40. View in: Pubmed

Shared human T cell receptor V beta usage to immunodominant regions of myelin basic protein. Science. 1990 May 25; 248(4958):1016-9. View in: Pubmed

Immunologic mechanisms in chronic demyelinating diseases of the central and peripheral nervous system. Res Publ Assoc Res Nerv Ment Dis. 1990; 68:105-16. View in: Pubmed

Gene activation during experimental allergic encephalomyelitis. Cloning of new cDNAs. Ann N Y Acad Sci. 1988; 540:264-5. View in: Pubmed