Cancer Genetics and Prevention

Below is a list of our current genetics and prevention trials and studies:

Breast cancer prevention studies

• BFOR: BRCA Founder Outreach (BFOR) Study
• The PROMISE Trial
• TamGel: 4-Hydroxytamoxifen Topical Gel in Breast Cancer Trial

Colon cancer studies

• Biomarker Trial of Naproxen for Patients with Lynch Syndrome
• FACES: Families Affected with Colon and Endometrial Cancers

Li-Fraumeni Syndrome research

• Li-Fraumeni and TP53: (LiFT UP)
• Li-Fraumeni Whole Body MRI Study

Lung cancer studies

• Clinical trials for EGFR-mutant lung cancers

Lynch syndrome research

• PREMM5: Prediction Model for Gene Mutations Application Study

Ovarian cancer prevention studies

• Denosumab: Pilot Study of Denosumab in BRCA1 or BRCA2 Mutation Carriers Scheduling Risk-Reducing Salpingo-Oophorectomy

Pancreatic cancer studies

• CAPS: Cancer of the Pancreas Screening Study
• GENERATE: GENetic Education, Risk Assessment, and TEsting
• PAGES: Clinical Study for Families with Multiple Cases of Pancreatic Cancer

Genetic studies

• ACT for Others: Tissue Repository Research Study
• EDRN 10: Early Detection Research Network
• IMPACT: Identification of Men with a Genetic Predisposition to Prostate Cancer: Targeted Screening in Men at Higher Genetic Risk and Controls
• MyFam: Multiple Myeloma in Families
• PROACTIVE: Research Study Looking at Inherited Genetic Material
• Project SEARCH Specimen Banking Protocol: Study of Environmental and Hereditary Factors Responsible for Cancer History
• PROMPT: Prospective Registry Of MultiPlex Testing

Why take part in a genetic research study?

While most genetic disorders cannot be cured, genetic research has provided – and continues to provide – new and improved treatments for individuals found to have genetic mutations associated with disease. Through continued research, doctors and scientists hope to provide more personalized disease treatments, while improving the speed and accuracy of genetic testing.

Progress in the identification of cancer genes and genetic syndromes, and in the management of individuals who have increased cancer risk, all comes from cancer research. Participation in clinical trials provides individuals with an opportunity to volunteer to become part of genetic research in a meaningful way. For those who elect to take part, clinical trials may provide access to new drugs and treatments, as well as closer monitoring by health care professionals.