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About the Chen-Huang Center for EGFR-Mutant Lung Cancers

  • Pasi Jänne, MD, PhD, Director of the Chen-Huang Center for EGFR-Mutant Lung Cancers

    Pasi Jänne, MD, PhD, Director of the Chen-Huang Center for EGFR-Mutant Lung Cancers


  • "Living with EGFR-Mutant Lung Cancer? You Are Not Alone!"
    Join Our 6-Week Virtual Course for Patients: June 15, June 22, June 29, July 6, July 13, July 20

    Facilitated by Michelle Jacobo, PhD, and Suzanne Welsh Lobacki, LICSW, you will learn to:

    • Restore balance, connection, and calm in your life
    • Develop clear, concise questions for your oncology team
    • Generate and communicate personalized solutions
    • Quick, easy, portable relaxation techniques
    • Enhance your social support
    • Reduce your physical and emotional symptoms
    • Apply research-tested strategies to help manage stress
    • Develop evidence-based coping skills for common EGFR concerns

    To learn more and/or enroll, contact Suzanne Welsh Lobacki, LICSW, at 617-632-6849 or suzanne_welshlobacki@dfci.harvard.edu.

    Mission and Goals

    Lung cancer remains the most common cause of cancer-related deaths in the United States for both men and women. Epidermal growth factor receptor (EGFR) mutations are found in 15 percent of lung cancer patients in the United States and European Union, and in 50 percent of lung cancer patients in Asia.

    Leading the Way

    In 2004, Dana-Farber investigators discovered that a subset of lung cancers exhibited mutations in the EGFR gene. These mutations were predictive of the clinical efficacy of EGFR kinase inhibitors. This discovery was one of the first examples of precision medicine for lung cancer, and helped catalyze the entire field of precision medicine for patients with lung cancer.

    Dana-Farber became one of the first American centers to begin routine clinical testing for EGFR mutations — which is now the standard of care worldwide. EGFR inhibitors are now used as the initial systemic therapy (instead of chemotherapy) for newly diagnosed patients with advanced EGFR-mutant lung cancers.

    Our Mission

    As part of Dana-Farber's Thoracic (Lung) Cancer Treatment Center, the Chen-Huang Center for EGFR-Mutant Lung Cancers will push the boundaries of knowledge in treating lung cancer, to develop new and better therapies. The mission of the Center is to improve the lives of patients with EGFR-mutant lung cancer through innovative research and cutting edge clinical care. This will be accomplished through the seamless integration of preclinical, translational, and clinical research, including:

    • New and novel clinical trials for patients with EGFR-mutant lung cancers
    • Translational studies of EGFR-mutant lung cancers to ultimately help refine therapeutic approaches for patients
    • Discovery studies that focus on the generation of research models
    • Education, training, and knowledge exchange opportunities for clinicians, researchers, and trainees from the U.S. and around the world, focusing on EGFR-mutant lung cancers

    About Winston Chen and Phyllis Huang

    The Chen-Huang Center was established with a $5 million gift from Winston Chen, PhD, and his wife, Phyllis Huang, to stimulate research, promote clinical trials, and strengthen Dana-Farber's capabilities for studying and treating EGFR-mutant lung cancer.

    For many years, the couple's family foundation, the Paramitas Foundation, focused on supporting higher education. Their recent funding has shifted to health care projects, specifically lung cancer care and research led by Pasi Jänne, MD, PhD, director of the Carole M. and Philip L. Lowe Center for Thoracic Oncology, and director of the Robert and Renée Belfer Center for Applied Cancer Science at Dana-Farber.

    "Phyllis and I hope our gift will bring much needed attention to lung cancer, and will illustrate how vital financial support is for making discoveries," said Chen. "We support Dr. Jänne and Dana-Farber because of their impressive centers, research facilities, and the discoveries they are making every day."

    Learn how you can help support the work of this Center.


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  • Pasi Jänne, MD, PhD, Director of the Chen-Huang Center for EGFR-Mutant Lung Cancers, describes how the Center will support and care for patients with epidermal growth factor receptor (EGFR)-mutant lung cancers.

  • A triathlete shares her powerful journey fighting EGFR-mutant lung cancer. And Pasi Jänne, MD, PhD, director of the Lowe Center for Thoracic Oncology and the Chen-Huang Center for EGFR-Mutant Lung Cancers, details the latest research into this disease.


  • View “Living with EGFR-Mutant Lung Cancer: A Virtual Forum for Patients and Caregivers,” the May, 2021 patient and caregiver forum hosted by the Chen-Huang Center for EGFR-Mutant Lung Cancers.


  • More Information on the Chen-Huang Center for EGFR-Mutant Lung Cancers

    Press release announcing the Chen-Huang Center

    Boston Herald's feature story about the Chen-Huang Center

    Hear from a patient treated for EFGR-mutant lung cancer