Trial ID:NCT03075072
Protocol #:16-305
Condition(s):Brain Metastases
Phase:III
Principal Investigator:Aizer, Ayal
Site Investigator(s):Tanguturi, Shyam, Kumar
Tanguturi, Shyam, Kumar
Site Research Nurse(s):Mann, Eileen, Marie
Roper, Kristin,
Spicer, Beverly, A.
Trial Description:
This research study is studying two different types of radiation as treatment for brain
metastases (tumors in the brain that spread from a cancer that originated elsewhere in the
body)
Eligibility Requirements:
- Participants must have a biopsy proven solid malignancy with untreated (by radiation)
intracranial lesions radiographically consistent with or pathologically proven to be
brain metastases. Patients who have undergone prior systemic therapy are eligible
- Five-twenty intracranial lesions must be present on MRI of the brain
- Age 18-80 years at diagnosis of brain metastases
- Karnofsky performance status of at least 70
Exclusion Criteria:
- Participants who have undergone prior radiation for brain metastases.
- Patients who have undergone resection of one or more brain metastases but who have not
yet started adjuvant radiotherapy are eligible for the study
- Participants who cannot undergo a brain MRI
- Participants who cannot receive gadolinium (MRI contrast)
- Participants with stage IV-V chronic kidney disease or end stage renal disease
- Participants with widespread, definitive leptomeningeal disease
- Participants with small cell lung cancer, lymphoma, or myeloma
- Participants with a maximum tumor diameter exceeding 5 cm (if not resected)
Protocol #: 16-305