Skip Navigation

Coronavirus (COVID-19) information for Dana-Farber patients & families Learn more

A. Thomas Look, MD


Pediatric Hematology/Oncology

No Ratings Available - Why Not?

Researcher

  • Professor of Pediatrics, Harvard Medical School

Contact Information

  • Office Phone Number(617) 632-5826
  • Fax(617) 632-6989

Bio

Dr. Look received his MD in 1975 and residency training in pediatrics at the University of Michigan. He completed a fellowship in pediatric oncology at St. Jude Children's Research Hospital, where he trained in the molecular biology of cancer and eventually became chair of the Experimental Oncology Department. In 1999, he joined DFCI as vice chair for research in the Department of Pediatric Oncology.

Recent Awards:

  • Second Annual Giulio J. D'Angio Lecturer, University of Pennsylvania Cancer Center 1999
  • Award for Excellence in Pediatric Research, American Academy of Pediatrics 1995
  • 2nd Annual Lecturer in Leukemia at The Hospital for Sick Children, Toronto, Canada 2000
  • ASPHO Frank A. Oski Memorial Lectureship Award 2005
  • Member, Association of American Physicians 2005

Research

Genetic Models of Leukemogenesis and Neuroblastoma

We are using zebrafish, in combination with murine and cell culture systems, to dissect developmental pathways subverted in human cancer. Zebrafish have been shown to share conserved pathways of development and disease pathogenesis with humans, thus permitting the identification of novel genes that are activated (oncogenes) or inactivated (tumor suppressors) during malignant transformation. We are using transgenic strategies to generate conditional zebrafish models of leukemias and solid tumors.We have identified novel genes regulating myelopoiesis, and are currently studying their respective contributions to the molecular pathogenesis of myelodysplastic syndrome and acute myeloid leukemia. We are applying similar approaches to study peripheral sympathetic nervous system development and to identify tumor suppressors in childhood neuroblastoma. We have also isolated a tumor-prone, mutant p53 zebrafish to study pathways involving this key regulator of DNA repair, cell cycle regulation, and apoptosis. p53 is the most commonly mutated gene in human cancers, and our zebrafish model is allowing us to study its role in several types of cancer.Our most advanced zebrafish model involves a transgenic line that develops T cell acute lymphoblastic leukemia (T-ALL). We are using this model to conduct one of the first cancer-related vertebrate genetic modifier screens, which will allow us to identify enhancers and suppressors of T-ALL progression. Using in vitro genome-scale location analysis (GSLA), we are also identifying the direct targets of oncogenic transcription factors and validating candidate target genes utilizing short interfering RNA strategies in human T-ALL cell lines. Through the combined use of these approaches, we hope to uncover novel genes and targets for the development of small-molecule inhibitors as therapeutics.In addition, we are studying apoptotic pathways controlled by the Slug transcription factor. We have shown that, in developing blood cells, DNA damage and p53 induction leads to the activation of Slug, which itself is a direct repressor of puma, a pro-apoptotic BH3-only protein. Mice deficient in both genes survive irradiation doses that are lethal to mice lacking Slug alone. Thus, Slug provides a novel mechanism downstream of p53 to ensure cell survival, rescuing damaged hematopoietic progenitors from programmed cell death, and allowing restorative repopulation of blood cells after radiation and other insults that cause DNA damage.

Super-enhancer-based identification of a BATF3/IL-2R-module reveals vulnerabilities in anaplastic large cell lymphoma. Nat Commun. 2021 09 22; 12(1):5577.
View in: PubMed

Association of allele-specific methylation of the ASNS gene with asparaginase sensitivity and prognosis in T-ALL. Blood Adv. 2021 Sep 17.
View in: PubMed

Synergistic melanoma cell death mediated by inhibition of both MCL1 and BCL2 in high-risk tumors driven by NF1/PTEN loss. Oncogene. 2021 Sep; 40(38):5718-5729.
View in: PubMed

Metabolic Enzyme DLST Promotes Tumor Aggression and Reveals a Vulnerability to OXPHOS Inhibition in High-Risk Neuroblastoma. Cancer Res. 2021 Sep 01; 81(17):4417-4430.
View in: PubMed

Integrative network analysis reveals USP7 haploinsufficiency inhibits E-protein activity in pediatric T-lineage acute lymphoblastic leukemia (T-ALL). Sci Rep. 2021 Mar 04; 11(1):5154.
View in: PubMed

GAS7 Deficiency Promotes Metastasis in MYCN-Driven Neuroblastoma. Cancer Res. 2021 06 01; 81(11):2995-3007.
View in: PubMed

Targeting ganglioneuromas with mTOR inhibitors. Mol Cell Oncol. 2021 Jan 10; 8(1):1856621.
View in: PubMed

Correction: Dependency on the TYK2/STAT1/MCL1 axis in anaplastic large cell lymphoma. Leukemia. 2020 Nov; 34(11):3105.
View in: PubMed

Ganglioneuromas are driven by activated AKT and can be therapeutically targeted with mTOR inhibitors. J Exp Med. 2020 10 05; 217(10).
View in: PubMed

suz12 inactivation in p53- and nf1-deficient zebrafish accelerates the onset of malignant peripheral nerve sheath tumors and expands the spectrum of tumor types. Dis Model Mech. 2020 08 27; 13(8).
View in: PubMed

ARID1A loss in neuroblastoma promotes the adrenergic-to-mesenchymal transition by regulating enhancer-mediated gene expression. Sci Adv. 2020 Jul; 6(29):eaaz3440.
View in: PubMed

Discovery of regulatory noncoding variants in individual cancer genomes by using cis-X. Nat Genet. 2020 08; 52(8):811-818.
View in: PubMed

LIN28B regulates transcription and potentiates MYCN-induced neuroblastoma through binding to ZNF143 at target gene promotors. Proc Natl Acad Sci U S A. 2020 07 14; 117(28):16516-16526.
View in: PubMed

Synthetic lethal targeting of TET2-mutant hematopoietic stem and progenitor cells (HSPCs) with TOP1-targeted drugs and PARP1 inhibitors. Leukemia. 2020 11; 34(11):2992-3006.
View in: PubMed

Allosteric Activators of Protein Phosphatase 2A Display Broad Antitumor Activity Mediated by Dephosphorylation of MYBL2. Cell. 2020 04 30; 181(3):702-715.e20.
View in: PubMed

Discovery of a selective inhibitor of doublecortin like kinase 1. Nat Chem Biol. 2020 06; 16(6):635-643.
View in: PubMed

suz12 inactivation in p53 and nf1 deficient zebrafish accelerates the onset of MPNSTs and expands the spectrum of tumor types to include adenocarcinoma, leukemia, and soft tissue sarcoma. Dis Model Mech. 2020 Jan 01.
View in: PubMed

ASCL1 is a MYCN- and LMO1-dependent member of the adrenergic neuroblastoma core regulatory circuitry. Nat Commun. 2019 12 09; 10(1):5622.
View in: PubMed

Mechanisms underlying synergy between DNA topoisomerase I-targeted drugs and mTOR kinase inhibitors in NF1-associated malignant peripheral nerve sheath tumors. Oncogene. 2019 09; 38(39):6585-6598.
View in: PubMed

High ENT1 and DCK gene expression levels are a potential biomarker to predict favorable response to nelarabine therapy in T-cell acute lymphoblastic leukemia. Hematol Oncol. 2019 Oct; 37(4):516-519.
View in: PubMed

Disruption of asxl1 results in myeloproliferative neoplasms in zebrafish. Dis Model Mech. 2019 05 07; 12(5).
View in: PubMed

Loss of atrx cooperates with p53-deficiency to promote the development of sarcomas and other malignancies. PLoS Genet. 2019 04; 15(4):e1008039.
View in: PubMed

Dependency on the TYK2/STAT1/MCL1 axis in anaplastic large cell lymphoma. Leukemia. 2019 03; 33(3):696-709.
View in: PubMed

Selective gene dependencies in MYCN-amplified neuroblastoma include the core transcriptional regulatory circuitry. Nat Genet. 2018 09; 50(9):1240-1246.
View in: PubMed

The MCL1-specific inhibitor S63845 acts synergistically with venetoclax/ABT-199 to induce apoptosis in T-cell acute lymphoblastic leukemia cells. Leukemia. 2019 01; 33(1):262-266.
View in: PubMed

JDP2: An oncogenic bZIP transcription factor in T cell acute lymphoblastic leukemia. J Exp Med. 2018 07 02; 215(7):1929-1945.
View in: PubMed

Cross-Cohort Analysis Identifies a TEAD4-MYCN Positive Feedback Loop as the Core Regulatory Element of High-Risk Neuroblastoma. Cancer Discov. 2018 05; 8(5):582-599.
View in: PubMed

Unraveling Neuroblastoma Pathogenesis with the Zebrafish. Cell Cycle. 2018; 17(4):395-396.
View in: PubMed

MYC Drives a Subset of High-Risk Pediatric Neuroblastomas and Is Activated through Mechanisms Including Enhancer Hijacking and Focal Enhancer Amplification. Cancer Discov. 2018 03; 8(3):320-335.
View in: PubMed

MYC-family protein overexpression and prominent nucleolar formation represent prognostic indicators and potential therapeutic targets for aggressive high-MKI neuroblastomas: a report from the children's oncology group. Oncotarget. 2018 Jan 19; 9(5):6416-6432.
View in: PubMed

TOX Regulates Growth, DNA Repair, and Genomic Instability in T-cell Acute Lymphoblastic Leukemia. Cancer Discov. 2017 11; 7(11):1336-1353.
View in: PubMed

LMO1 Synergizes with MYCN to Promote Neuroblastoma Initiation and Metastasis. Cancer Cell. 2017 09 11; 32(3):310-323.e5.
View in: PubMed

Zebrafish B Cell Development without a Pre-B Cell Stage, Revealed by CD79 Fluorescence Reporter Transgenes. J Immunol. 2017 09 01; 199(5):1706-1715.
View in: PubMed

Corrigendum: Small genomic insertions form enhancers that misregulate oncogenes. Nat Commun. 2017 06 01; 8:15797.
View in: PubMed

Critical Role for GAB2 in Neuroblastoma Pathogenesis through the Promotion of SHP2/MYCN Cooperation. Cell Rep. 2017 03 21; 18(12):2932-2942.
View in: PubMed

Anti-leukaemic activity of the TYK2 selective inhibitor NDI-031301 in T-cell acute lymphoblastic leukaemia. Br J Haematol. 2017 04; 177(2):271-282.
View in: PubMed

Activation of the LMO2 oncogene through a somatically acquired neomorphic promoter in T-cell acute lymphoblastic leukemia. Blood. 2017 06 15; 129(24):3221-3226.
View in: PubMed

The pre-rRNA processing factor DEF is rate limiting for the pathogenesis of MYCN-driven neuroblastoma. Oncogene. 2017 07 06; 36(27):3852-3867.
View in: PubMed

APOBEC signature mutation generates an oncogenic enhancer that drives LMO1 expression in T-ALL. Leukemia. 2017 10; 31(10):2057-2064.
View in: PubMed

Small genomic insertions form enhancers that misregulate oncogenes. Nat Commun. 2017 02 09; 8:14385.
View in: PubMed

Zebrafish models of leukemia. Methods Cell Biol. 2017; 138:563-592.
View in: PubMed

Combined targeting of SET and tyrosine kinases provides an effective therapeutic approach in human T-cell acute lymphoblastic leukemia. Oncotarget. 2016 Dec 20; 7(51):84214-84227.
View in: PubMed

Overexpression of PDGFRA cooperates with loss of NF1 and p53 to accelerate the molecular pathogenesis of malignant peripheral nerve sheath tumors. Oncogene. 2017 02 23; 36(8):1058-1068.
View in: PubMed

The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice. Cancer Cell. 2016 07 11; 30(1):183.
View in: PubMed

KPT-8602, a second-generation inhibitor of XPO1-mediated nuclear export, is well tolerated and highly active against AML blasts and leukemia-initiating cells. Leukemia. 2017 01; 31(1):143-150.
View in: PubMed

Synergy between loss of NF1 and overexpression of MYCN in neuroblastoma is mediated by the GAP-related domain. Elife. 2016 04 27; 5.
View in: PubMed

The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice. Cancer Cell. 2016 04 11; 29(4):574-586.
View in: PubMed

Imaging tumour cell heterogeneity following cell transplantation into optically clear immune-deficient zebrafish. Nat Commun. 2016 Jan 21; 7:10358.
View in: PubMed

Malignant Peripheral Nerve Sheath Tumors. Adv Exp Med Biol. 2016; 916:495-530.
View in: PubMed

Genetic predisposition to neuroblastoma mediated by a LMO1 super-enhancer polymorphism. Nature. 2015 Dec 17; 528(7582):418-21.
View in: PubMed

From bench to patient: model systems in drug discovery. Dis Model Mech. 2015 Oct 01; 8(10):1171-4.
View in: PubMed

HSP90 inhibition leads to degradation of the TYK2 kinase and apoptotic cell death in T-cell acute lymphoblastic leukemia. Leukemia. 2016 Jan; 30(1):219-28.
View in: PubMed

Activity of a selective inhibitor of nuclear export, selinexor (KPT-330), against AML-initiating cells engrafted into immunosuppressed NSG mice. Leukemia. 2016 Jan; 30(1):190-9.
View in: PubMed

A zebrafish model of myelodysplastic syndrome produced through tet2 genomic editing. Mol Cell Biol. 2015 Mar; 35(5):789-804.
View in: PubMed

Oncogene regulation. An oncogenic super-enhancer formed through somatic mutation of a noncoding intergenic element. Science. 2014 Dec 12; 346(6215):1373-7.
View in: PubMed

Cyclin C is a haploinsufficient tumour suppressor. Nat Cell Biol. 2014 Nov; 16(11):1080-91.
View in: PubMed

Targeting oncogenic interleukin-7 receptor signalling with N-acetylcysteine in T cell acute lymphoblastic leukaemia. Br J Haematol. 2015 Jan; 168(2):230-8.
View in: PubMed

The chromatin remodeling factor CHD5 is a transcriptional repressor of WEE1. PLoS One. 2014; 9(9):e108066.
View in: PubMed

Age-dependent prognostic effect by Mitosis-Karyorrhexis Index in neuroblastoma: a report from the Children's Oncology Group. Pediatr Dev Pathol. 2014 Nov-Dec; 17(6):441-9.
View in: PubMed

L-Leucine improves the anaemia in models of Diamond Blackfan anaemia and the 5q- syndrome in a TP53-independent way. Br J Haematol. 2014 Nov; 167(4):524-528.
View in: PubMed

Ribonucleoprotein HNRNPA2B1 interacts with and regulates oncogenic KRAS in pancreatic ductal adenocarcinoma cells. Gastroenterology. 2014 Oct; 147(4):882-892.e8.
View in: PubMed

Loss of function tp53 mutations do not accelerate the onset of myc-induced T-cell acute lymphoblastic leukaemia in the zebrafish. Br J Haematol. 2014 Jul; 166(1):84-90.
View in: PubMed

Notch signaling: switching an oncogene to a tumor suppressor. Blood. 2014 Apr 17; 123(16):2451-9.
View in: PubMed

Repression of BIM mediates survival signaling by MYC and AKT in high-risk T-cell acute lymphoblastic leukemia. Leukemia. 2014 Sep; 28(9):1819-27.
View in: PubMed

Phenothiazines induce PP2A-mediated apoptosis in T cell acute lymphoblastic leukemia. J Clin Invest. 2014 Feb; 124(2):644-55.
View in: PubMed

c-Myc inhibition prevents leukemia initiation in mice and impairs the growth of relapsed and induction failure pediatric T-ALL cells. Blood. 2014 Feb 13; 123(7):1040-50.
View in: PubMed

Immature MEF2C-dysregulated T-cell leukemia patients have an early T-cell precursor acute lymphoblastic leukemia gene signature and typically have non-rearranged T-cell receptors. Haematologica. 2014 Jan; 99(1):94-102.
View in: PubMed

Neuroblastoma of undifferentiated subtype, prognostic significance of prominent nucleolar formation, and MYC/MYCN protein expression: a report from the Children's Oncology Group. Cancer. 2013 Oct 15; 119(20):3718-26.
View in: PubMed

MYBL2 is a sub-haploinsufficient tumor suppressor gene in myeloid malignancy. Elife. 2013 Jul 16; 2:e00825.
View in: PubMed

The TAL1 complex targets the FBXW7 tumor suppressor by activating miR-223 in human T cell acute lymphoblastic leukemia. J Exp Med. 2013 Jul 29; 210(8):1545-57.
View in: PubMed

Discovery of a selective irreversible BMX inhibitor for prostate cancer. ACS Chem Biol. 2013 Jul 19; 8(7):1423-8.
View in: PubMed

TYK2-STAT1-BCL2 pathway dependence in T-cell acute lymphoblastic leukemia. Cancer Discov. 2013 May; 3(5):564-77.
View in: PubMed

The requirement for cyclin D function in tumor maintenance. Cancer Cell. 2012 Oct 16; 22(4):438-51.
View in: PubMed

Inactivation of ribosomal protein L22 promotes transformation by induction of the stemness factor, Lin28B. Blood. 2012 Nov 01; 120(18):3764-73.
View in: PubMed

Distinct and dynamic requirements for mTOR signaling in hematopoiesis and leukemogenesis. Cell Stem Cell. 2012 Sep 07; 11(3):281-2.
View in: PubMed

Ccdc94 protects cells from ionizing radiation by inhibiting the expression of p53. PLoS Genet. 2012; 8(8):e1002922.
View in: PubMed

Core transcriptional regulatory circuit controlled by the TAL1 complex in human T cell acute lymphoblastic leukemia. Cancer Cell. 2012 Aug 14; 22(2):209-21.
View in: PubMed

Antileukemic activity of nuclear export inhibitors that spare normal hematopoietic cells. Leukemia. 2013 Jan; 27(1):66-74.
View in: PubMed

PIDD death-domain phosphorylation by ATM controls prodeath versus prosurvival PIDDosome signaling. Mol Cell. 2012 Sep 14; 47(5):681-93.
View in: PubMed

Zebrafish neurofibromatosis type 1 genes have redundant functions in tumorigenesis and embryonic development. Dis Model Mech. 2012 Nov; 5(6):881-94.
View in: PubMed

Autocrine activation of the MET receptor tyrosine kinase in acute myeloid leukemia. Nat Med. 2012 Jul; 18(7):1118-22.
View in: PubMed

NOTCH1 signaling promotes human T-cell acute lymphoblastic leukemia initiating cell regeneration in supportive niches. PLoS One. 2012; 7(6):e39725.
View in: PubMed

Peripheral neuroblastic tumors with genotype-phenotype discordance: a report from the Children's Oncology Group and the International Neuroblastoma Pathology Committee. Pediatr Blood Cancer. 2013 Mar; 60(3):363-70.
View in: PubMed

L-Leucine improves the anemia and developmental defects associated with Diamond-Blackfan anemia and del(5q) MDS by activating the mTOR pathway. Blood. 2012 Sep 13; 120(11):2214-24.
View in: PubMed

Notch signaling expands a pre-malignant pool of T-cell acute lymphoblastic leukemia clones without affecting leukemia-propagating cell frequency. Leukemia. 2012 Sep; 26(9):2069-78.
View in: PubMed

Activated ALK collaborates with MYCN in neuroblastoma pathogenesis. Cancer Cell. 2012 Mar 20; 21(3):362-73.
View in: PubMed

Kinome-wide selectivity profiling of ATP-competitive mammalian target of rapamycin (mTOR) inhibitors and characterization of their binding kinetics. J Biol Chem. 2012 Mar 23; 287(13):9742-9752.
View in: PubMed

Discovery of a secreted tumor suppressor provides a promising therapeutic strategy for follicular lymphoma. Cancer Cell. 2011 Nov 15; 20(5):559-61.
View in: PubMed

Evaluation and application of modularly assembled zinc-finger nucleases in zebrafish. Development. 2011 Oct; 138(20):4555-64.
View in: PubMed

Aberrant AKT activation drives well-differentiated liposarcoma. Proc Natl Acad Sci U S A. 2011 Sep 27; 108(39):16386-91.
View in: PubMed

p63 mediates an apoptotic response to pharmacological and disease-related ER stress in the developing epidermis. Dev Cell. 2011 Sep 13; 21(3):492-505.
View in: PubMed

The BCL11B tumor suppressor is mutated across the major molecular subtypes of T-cell acute lymphoblastic leukemia. Blood. 2011 Oct 13; 118(15):4169-73.
View in: PubMed

NUP98-HOXA9-transgenic zebrafish develop a myeloproliferative neoplasm and provide new insight into mechanisms of myeloid leukaemogenesis. Br J Haematol. 2011 Oct; 155(2):167-81.
View in: PubMed

Pten mediates Myc oncogene dependence in a conditional zebrafish model of T cell acute lymphoblastic leukemia. J Exp Med. 2011 Aug 01; 208(8):1595-603.
View in: PubMed

Ddx18 is essential for cell-cycle progression in zebrafish hematopoietic cells and is mutated in human AML. Blood. 2011 Jul 28; 118(4):903-15.
View in: PubMed

Repression of tumor suppressor miR-451 is essential for NOTCH1-induced oncogenesis in T-ALL. J Exp Med. 2011 Apr 11; 208(4):663-75.
View in: PubMed

cpsf1 is required for definitive HSC survival in zebrafish. Blood. 2011 Apr 14; 117(15):3996-4007.
View in: PubMed

Zebrafish as a model for the study of human cancer. Methods Cell Biol. 2011; 105:309-37.
View in: PubMed

mll ortholog containing functional domains of human MLL is expressed throughout the zebrafish lifespan and in haematopoietic tissues. Br J Haematol. 2011 Feb; 152(3):307-21.
View in: PubMed

Zebrafish microRNA-126 determines hematopoietic cell fate through c-Myb. Leukemia. 2011 Mar; 25(3):506-14.
View in: PubMed

T-lymphoblastic lymphoma cells express high levels of BCL2, S1P1, and ICAM1, leading to a blockade of tumor cell intravasation. Cancer Cell. 2010 Oct 19; 18(4):353-66.
View in: PubMed

Outcome after reduced chemotherapy for intermediate-risk neuroblastoma. N Engl J Med. 2010 Sep 30; 363(14):1313-23.
View in: PubMed

Oligodendrocyte progenitor cell numbers and migration are regulated by the zebrafish orthologs of the NF1 tumor suppressor gene. Hum Mol Genet. 2010 Dec 01; 19(23):4643-53.
View in: PubMed

Absence of biallelic TCRgamma deletion predicts early treatment failure in pediatric T-cell acute lymphoblastic leukemia. J Clin Oncol. 2010 Aug 20; 28(24):3816-23.
View in: PubMed

ATM-deficient thymic lymphoma is associated with aberrant tcrd rearrangement and gene amplification. J Exp Med. 2010 Jul 05; 207(7):1369-80.
View in: PubMed

Aberrant induction of LMO2 by the E2A-HLF chimeric transcription factor and its implication in leukemogenesis of B-precursor ALL with t(17;19). Blood. 2010 Aug 12; 116(6):962-70.
View in: PubMed

Phosphatase-dependent and -independent functions of Shp2 in neural crest cells underlie LEOPARD syndrome pathogenesis. Dev Cell. 2010 May 18; 18(5):750-62.
View in: PubMed

Deletion of proapoptotic Puma selectively protects hematopoietic stem and progenitor cells against high-dose radiation. Blood. 2010 Jun 10; 115(23):4707-14.
View in: PubMed

SNP array analysis in hematologic malignancies: avoiding false discoveries. Blood. 2010 May 27; 115(21):4157-61.
View in: PubMed

Expression of the cytoplasmic NPM1 mutant (NPMc+) causes the expansion of hematopoietic cells in zebrafish. Blood. 2010 Apr 22; 115(16):3329-40.
View in: PubMed

Inactivation of LEF1 in T-cell acute lymphoblastic leukemia. Blood. 2010 Apr 08; 115(14):2845-51.
View in: PubMed

Studying peripheral sympathetic nervous system development and neuroblastoma in zebrafish. Methods Cell Biol. 2010; 100:127-52.
View in: PubMed

Interconnecting molecular pathways in the pathogenesis and drug sensitivity of T-cell acute lymphoblastic leukemia. Blood. 2010 Mar 04; 115(9):1735-45.
View in: PubMed

Nfil3/E4bp4 is required for the development and maturation of NK cells in vivo. J Exp Med. 2009 Dec 21; 206(13):2977-86.
View in: PubMed

Cardiac and vascular functions of the zebrafish orthologues of the type I neurofibromatosis gene NFI. Proc Natl Acad Sci U S A. 2009 Dec 29; 106(52):22305-10.
View in: PubMed

Up-regulation of survivin by the E2A-HLF chimera is indispensable for the survival of t(17;19)-positive leukemia cells. J Biol Chem. 2010 Jan 15; 285(3):1850-60.
View in: PubMed

Clinicopathological characteristics of ganglioneuroma and ganglioneuroblastoma: a report from the CCG and COG. Pediatr Blood Cancer. 2009 Oct; 53(4):563-9.
View in: PubMed

Emi1 maintains genomic integrity during zebrafish embryogenesis and cooperates with p53 in tumor suppression. Mol Cell Biol. 2009 Nov; 29(21):5911-22.
View in: PubMed

The ENTH domain protein Clint1 is required for epidermal homeostasis in zebrafish. Development. 2009 Aug; 136(15):2591-600.
View in: PubMed

A tissue-scale gradient of hydrogen peroxide mediates rapid wound detection in zebrafish. Nature. 2009 Jun 18; 459(7249):996-9.
View in: PubMed

High frequency of PTEN, PI3K, and AKT abnormalities in T-cell acute lymphoblastic leukemia. Blood. 2009 Jul 16; 114(3):647-50.
View in: PubMed

Comparison of primary neuroblastoma tumors and derivative early-passage cell lines using genome-wide single nucleotide polymorphism array analysis. Cancer Res. 2009 May 15; 69(10):4143-9.
View in: PubMed

Accurate detection of uniparental disomy and microdeletions by SNP array analysis in myelodysplastic syndromes with normal cytogenetics. Leukemia. 2009 Sep; 23(9):1605-13.
View in: PubMed

CHK1 inhibition as a strategy for targeting Fanconi Anemia (FA) DNA repair pathway deficient tumors. Mol Cancer. 2009 Apr 16; 8:24.
View in: PubMed

Inhibition of NOTCH signaling by gamma secretase inhibitor engages the RB pathway and elicits cell cycle exit in T-cell acute lymphoblastic leukemia cells. Cancer Res. 2009 Apr 01; 69(7):3060-8.
View in: PubMed

Anaplastic lymphoma kinase: role in cancer pathogenesis and small-molecule inhibitor development for therapy. Expert Rev Anticancer Ther. 2009 Mar; 9(3):331-56.
View in: PubMed

Smooth muscle cells give rise to osteochondrogenic precursors and chondrocytes in calcifying arteries. Circ Res. 2009 Mar 27; 104(6):733-41.
View in: PubMed

Construction and application of a zebrafish array comparative genomic hybridization platform. Genes Chromosomes Cancer. 2009 Feb; 48(2):155-70.
View in: PubMed

Muscle degeneration and leukocyte infiltration caused by mutation of zebrafish Fad24. Dev Dyn. 2009 Jan; 238(1):86-99.
View in: PubMed

Activating mutations in ALK provide a therapeutic target in neuroblastoma. Nature. 2008 Oct 16; 455(7215):975-8.
View in: PubMed

In vivo interstitial migration of primitive macrophages mediated by JNK-matrix metalloproteinase 13 signaling in response to acute injury. J Immunol. 2008 Aug 01; 181(3):2155-64.
View in: PubMed

Chk1 suppresses a caspase-2 apoptotic response to DNA damage that bypasses p53, Bcl-2, and caspase-3. Cell. 2008 May 30; 133(5):864-77.
View in: PubMed

BIM and other BCL-2 family proteins exhibit cross-species conservation of function between zebrafish and mammals. Cell Death Differ. 2008 Jun; 15(6):1063-72.
View in: PubMed

Acute lymphoblastic leukaemia. Lancet. 2008 Mar 22; 371(9617):1030-43.
View in: PubMed

Co-injection strategies to modify radiation sensitivity and tumor initiation in transgenic Zebrafish. Oncogene. 2008 Jul 10; 27(30):4242-8.
View in: PubMed

The kinesin KIF1Bbeta acts downstream from EglN3 to induce apoptosis and is a potential 1p36 tumor suppressor. Genes Dev. 2008 Apr 01; 22(7):884-93.
View in: PubMed

SOS1 mutations are rare in human malignancies: implications for Noonan Syndrome patients. Genes Chromosomes Cancer. 2008 Mar; 47(3):253-9.
View in: PubMed

Mutations in the neutral sphingomyelinase gene SMPD3 implicate the ceramide pathway in human leukemias. Blood. 2008 May 01; 111(9):4716-22.
View in: PubMed

Clinical significance of MYCN amplification and ploidy in favorable-stage neuroblastoma: a report from the Children's Oncology Group. J Clin Oncol. 2008 Feb 20; 26(6):913-8.
View in: PubMed

Alu elements mediate MYB gene tandem duplication in human T-ALL. J Exp Med. 2007 Dec 24; 204(13):3059-66.
View in: PubMed

Neuroblastoma cells isolated from bone marrow metastases contain a naturally enriched tumor-initiating cell. Cancer Res. 2007 Dec 01; 67(23):11234-43.
View in: PubMed

NOTCH and PI3K-AKT pathways intertwined. Cancer Cell. 2007 Nov; 12(5):411-3.
View in: PubMed

Mechanisms of transcription factor deregulation in lymphoid cell transformation. Oncogene. 2007 Oct 15; 26(47):6838-49.
View in: PubMed

Live imaging of chronic inflammation caused by mutation of zebrafish Hai1. J Cell Sci. 2007 Oct 01; 120(Pt 19):3372-83.
View in: PubMed

A Rap GTPase interactor, RADIL, mediates migration of neural crest precursors. Genes Dev. 2007 Sep 01; 21(17):2131-6.
View in: PubMed

FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to gamma-secretase inhibitors. J Exp Med. 2007 Aug 06; 204(8):1813-24.
View in: PubMed

Heat-shock induction of T-cell lymphoma/leukaemia in conditional Cre/lox-regulated transgenic zebrafish. Br J Haematol. 2007 Jul; 138(2):169-75.
View in: PubMed

Targeting transcription factors in acute leukemia in children. Curr Drug Targets. 2007 Jun; 8(6):727-37.
View in: PubMed

Chromosomally unstable mouse tumours have genomic alterations similar to diverse human cancers. Nature. 2007 Jun 21; 447(7147):966-71.
View in: PubMed

Genome-wide analysis of neuroblastomas using high-density single nucleotide polymorphism arrays. PLoS One. 2007 Feb 28; 2(2):e255.
View in: PubMed

Beta-catenin stabilization stalls the transition from double-positive to single-positive stage and predisposes thymocytes to malignant transformation. Blood. 2007 Jun 15; 109(12):5463-72.
View in: PubMed

Apoptosis in T cell acute lymphoblastic leukemia cells after cell cycle arrest induced by pharmacological inhibition of notch signaling. Chem Biol. 2007 Feb; 14(2):209-19.
View in: PubMed

Dominant-interfering C/EBPalpha stimulates primitive erythropoiesis in zebrafish. Exp Hematol. 2007 Feb; 35(2):230-9.
View in: PubMed

NOTCH1-induced T-cell leukemia in transgenic zebrafish. Leukemia. 2007 Mar; 21(3):462-71.
View in: PubMed

Identification of structural aberrations in cancer by SNP array analysis. Genome Biol. 2007; 8(7):219.
View in: PubMed

Zebrafish as a powerful vertebrate model system for in vivo studies of cell death. Semin Cancer Biol. 2007 Apr; 17(2):154-65.
View in: PubMed

Chromosome 5q deletion and epigenetic suppression of the gene encoding alpha-catenin (CTNNA1) in myeloid cell transformation. Nat Med. 2007 Jan; 13(1):78-83.
View in: PubMed

NOTCH1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth. Proc Natl Acad Sci U S A. 2006 Nov 28; 103(48):18261-6.
View in: PubMed

Does MYCN amplification manifested as homogeneously staining regions at diagnosis predict a worse outcome in children with neuroblastoma? A Children's Oncology Group study. Clin Cancer Res. 2006 Oct 01; 12(19):5693-7.
View in: PubMed

Resolution of inflammation by retrograde chemotaxis of neutrophils in transgenic zebrafish. J Leukoc Biol. 2006 Dec; 80(6):1281-8.
View in: PubMed

Notch 1 activation in the molecular pathogenesis of T-cell acute lymphoblastic leukaemia. Nat Rev Cancer. 2006 May; 6(5):347-59.
View in: PubMed

Transcriptional regulatory networks downstream of TAL1/SCL in T-cell acute lymphoblastic leukemia. Blood. 2006 Aug 01; 108(3):986-92.
View in: PubMed

Zebrafish foxd3 is selectively required for neural crest specification, migration and survival. Dev Biol. 2006 Apr 01; 292(1):174-88.
View in: PubMed

Fishing for cancer models. Nat Biotechnol. 2006 Jan; 24(1):45-6.
View in: PubMed

Small molecules thwart crash and burn. Nat Chem Biol. 2005 Dec; 1(7):351-3.
View in: PubMed

Outcomes of children with intermediate-risk neuroblastoma after treatment stratified by MYCN status and tumor cell ploidy. J Clin Oncol. 2005 Dec 01; 23(34):8819-27.
View in: PubMed

Chromosome 1p and 11q deletions and outcome in neuroblastoma. N Engl J Med. 2005 Nov 24; 353(21):2243-53.
View in: PubMed

Slug antagonizes p53-mediated apoptosis of hematopoietic progenitors by repressing puma. Cell. 2005 Nov 18; 123(4):641-53.
View in: PubMed

State of the Art and Future Needs in Cytogenetic/Molecular Genetics/Arrays in childhood lymphoma: summary report of workshop at the First International Symposium on childhood and adolescent non-Hodgkin lymphoma, April 9, 2003, New York City, NY. Pediatr Blood Cancer. 2005 Oct 15; 45(5):616-22.
View in: PubMed

Activating Notch1 mutations in mouse models of T-ALL. Blood. 2006 Jan 15; 107(2):781-5.
View in: PubMed

Molecular genetics of acute lymphoblastic leukemia. J Clin Oncol. 2005 Sep 10; 23(26):6306-15.
View in: PubMed

Zebrafish as a model for myelopoiesis during embryogenesis. Exp Hematol. 2005 Sep; 33(9):997-1006.
View in: PubMed

Hyperdiploidy plus nonamplified MYCN confers a favorable prognosis in children 12 to 18 months old with disseminated neuroblastoma: a Pediatric Oncology Group study. J Clin Oncol. 2005 Sep 20; 23(27):6466-73.
View in: PubMed

The JAK2V617F activating mutation occurs in chronic myelomonocytic leukemia and acute myeloid leukemia, but not in acute lymphoblastic leukemia or chronic lymphocytic leukemia. Blood. 2005 Nov 15; 106(10):3377-9.
View in: PubMed

CD34+ cell selection is required to assess HOXA9 expression levels in patients with myelodysplastic syndrome. Br J Haematol. 2005 Jul; 130(1):83-6.
View in: PubMed

Evidence for an age cut-off greater than 365 days for neuroblastoma risk group stratification in the Children's Oncology Group (COG). J Clin Oncol. 2005 Jun; 23(16_suppl):8500.
View in: PubMed

A phase I study of decitabine (DCT) in combination with doxorubicin (DOX) and cyclophosphamide (CTX) in the treatment of relapsed or refractory solid tumors: A Children's Oncology Group Study. J Clin Oncol. 2005 Jun; 23(16_suppl):8530.
View in: PubMed

Cre/lox-regulated transgenic zebrafish model with conditional myc-induced T cell acute lymphoblastic leukemia. Proc Natl Acad Sci U S A. 2005 Apr 26; 102(17):6068-73.
View in: PubMed

The BCL2A1 gene as a pre-T cell receptor-induced regulator of thymocyte survival. J Exp Med. 2005 Feb 21; 201(4):603-14.
View in: PubMed

BRAF mutations are sufficient to promote nevi formation and cooperate with p53 in the genesis of melanoma. Curr Biol. 2005 Feb 08; 15(3):249-54.
View in: PubMed

TEF, an antiapoptotic bZIP transcription factor related to the oncogenic E2A-HLF chimera, inhibits cell growth by down-regulating expression of the common beta chain of cytokine receptors. Blood. 2005 Jun 01; 105(11):4437-44.
View in: PubMed

tp53 mutant zebrafish develop malignant peripheral nerve sheath tumors. Proc Natl Acad Sci U S A. 2005 Jan 11; 102(2):407-12.
View in: PubMed

Molecular Pathogenesis of MDS. Hematology Am Soc Hematol Educ Program. 2005; 156-60.
View in: PubMed

Interplay of pu.1 and gata1 determines myelo-erythroid progenitor cell fate in zebrafish. Dev Cell. 2005 Jan; 8(1):97-108.
View in: PubMed

Suppression of apoptosis by bcl-2 overexpression in lymphoid cells of transgenic zebrafish. Blood. 2005 Apr 15; 105(8):3278-85.
View in: PubMed

Molecular pathways in T-cell acute lympho-blastic leukemia: ramifications for therapy. Clin Adv Hematol Oncol. 2004 Dec; 2(12):779-80.
View in: PubMed

DNA microarrays in the diagnosis and management of acute lymphoblastic leukemia. Int J Hematol. 2004 Dec; 80(5):395-400.
View in: PubMed

Hematopoietic gene expression profile in zebrafish kidney marrow. Proc Natl Acad Sci U S A. 2004 Nov 16; 101(46):16240-5.
View in: PubMed

Targeted expression of human MYCN selectively causes pancreatic neuroendocrine tumors in transgenic zebrafish. Cancer Res. 2004 Oct 15; 64(20):7256-62.
View in: PubMed

Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia. Science. 2004 Oct 08; 306(5694):269-71.
View in: PubMed

Fusion of NUP214 to ABL1 on amplified episomes in T-cell acute lymphoblastic leukemia. Nat Genet. 2004 Oct; 36(10):1084-9.
View in: PubMed

Effects of lethal irradiation in zebrafish and rescue by hematopoietic cell transplantation. Blood. 2004 Sep 01; 104(5):1298-305.
View in: PubMed

In vivo tracking of T cell development, ablation, and engraftment in transgenic zebrafish. Proc Natl Acad Sci U S A. 2004 May 11; 101(19):7369-74.
View in: PubMed

The use of zebrafish to understand immunity. Immunity. 2004 Apr; 20(4):367-79.
View in: PubMed

Activating FLT3 mutations in CD117/KIT(+) T-cell acute lymphoblastic leukemias. Blood. 2004 Jul 15; 104(2):558-60.
View in: PubMed

The pu.1 promoter drives myeloid gene expression in zebrafish. Blood. 2004 Sep 01; 104(5):1291-7.
View in: PubMed

Prognostic importance of TLX1 (HOX11) oncogene expression in adults with T-cell acute lymphoblastic leukaemia. Lancet. 2004 Feb 14; 363(9408):535-6.
View in: PubMed

Lessons from transgenic zebrafish expressing the green fluorescent protein (GFP) in the myeloid lineage. Methods Cell Biol. 2004; 77:333-47.
View in: PubMed

Zebrafish sperm cryopreservation. Methods Cell Biol. 2004; 77:645-59.
View in: PubMed

Development of the peripheral sympathetic nervous system in zebrafish. Methods Cell Biol. 2004; 76:237-60.
View in: PubMed

Regulation of annexin II by cytokine-initiated signaling pathways and E2A-HLF oncoprotein. Blood. 2004 Apr 15; 103(8):3185-91.
View in: PubMed

Knockdown of zebrafish Fancd2 causes developmental abnormalities via p53-dependent apoptosis. Dev Cell. 2003 Dec; 5(6):903-14.
View in: PubMed

IL-7-dependent human leukemia T-cell line as a valuable tool for drug discovery in T-ALL. Blood. 2004 Mar 01; 103(5):1891-900.
View in: PubMed

Biallelic transcriptional activation of oncogenic transcription factors in T-cell acute lymphoblastic leukemia. Blood. 2004 Mar 01; 103(5):1909-11.
View in: PubMed

Zebrafish as a model organism for blood diseases. Br J Haematol. 2003 Nov; 123(4):568-76.
View in: PubMed

Zebrafish sperm cryopreservation with N,N-dimethylacetamide. Biotechniques. 2003 Nov; 35(5):956-8, 960, 962 passim.
View in: PubMed

Gene expression profiling in T-cell acute lymphoblastic leukemia. Semin Hematol. 2003 Oct; 40(4):274-80.
View in: PubMed

Turning on a dimer: new insights into MLL chimeras. Cancer Cell. 2003 Aug; 4(2):81-3.
View in: PubMed

Gene expression signatures in MLL-rearranged T-lineage and B-precursor acute leukemias: dominance of HOX dysregulation. Blood. 2003 Jul 01; 102(1):262-8.
View in: PubMed

Myc-induced T cell leukemia in transgenic zebrafish. Science. 2003 Feb 07; 299(5608):887-90.
View in: PubMed

No evidence for the presence of an imprinted neuroblastoma suppressor gene within chromosome sub-band 1p36.3. Cancer Res. 2002 Nov 15; 62(22):6481-4.
View in: PubMed

Slug, a highly conserved zinc finger transcriptional repressor, protects hematopoietic progenitor cells from radiation-induced apoptosis in vivo. Cancer Cell. 2002 Oct; 2(4):279-88.
View in: PubMed

Molecular cloning and developmental expression of Tlx (Hox11) genes in zebrafish (Danio rerio). Mech Dev. 2002 Sep; 117(1-2):243-8.
View in: PubMed

A leukemogenic twist for GATA1. Nat Genet. 2002 Sep; 32(1):83-4.
View in: PubMed

Evolutionary conservation of zebrafish linkage group 14 with frequently deleted regions of human chromosome 5 in myeloid malignancies. Proc Natl Acad Sci U S A. 2002 Apr 30; 99(9):6136-41.
View in: PubMed

Gene expression signatures define novel oncogenic pathways in T cell acute lymphoblastic leukemia. Cancer Cell. 2002 Feb; 1(1):75-87.
View in: PubMed

E2A-HLF usurps control of evolutionarily conserved survival pathways. Oncogene. 2001 Sep 10; 20(40):5718-25.
View in: PubMed

The E2A-HLF oncoprotein activates Groucho-related genes and suppresses Runx1. Mol Cell Biol. 2001 Sep; 21(17):5935-45.
View in: PubMed

Myelopoiesis in the zebrafish, Danio rerio. Blood. 2001 Aug 01; 98(3):643-51.
View in: PubMed

Zebrafish myelopoiesis and blood cell development. Curr Opin Hematol. 2001 Jul; 8(4):245-51.
View in: PubMed

The association of the TEL-AML1 chromosomal translocation with the accumulation of methotrexate polyglutamates in lymphoblasts and with ploidy in childhood B-progenitor cell acute lymphoblastic leukemia: a Pediatric Oncology Group study. Leukemia. 2001 Jul; 15(7):1081-8.
View in: PubMed

Downregulation of Bim, a proapoptotic relative of Bcl-2, is a pivotal step in cytokine-initiated survival signaling in murine hematopoietic progenitors. Mol Cell Biol. 2001 Feb; 21(3):854-64.
View in: PubMed

Clinical implications of recurring chromosomal and associated molecular abnormalities in acute lymphoblastic leukemia. Semin Hematol. 2000 Oct; 37(4):381-95.
View in: PubMed

Parental smoking and alcohol consumption and risk of neuroblastoma. Cancer Epidemiol Biomarkers Prev. 2000 Sep; 9(9):967-72.
View in: PubMed

SLUG, a ces-1-related zinc finger transcription factor gene with antiapoptotic activity, is a downstream target of the E2A-HLF oncoprotein. Mol Cell. 1999 Sep; 4(3):343-52.
View in: PubMed

Netrin-1: interaction with deleted in colorectal cancer (DCC) and alterations in brain tumors and neuroblastomas. Cell Growth Differ. 1999 Jan; 10(1):35-42.
View in: PubMed

Inactivating mutations in an SH2 domain-encoding gene in X-linked lymphoproliferative syndrome. Proc Natl Acad Sci U S A. 1998 Nov 10; 95(23):13765-70.
View in: PubMed

Developmental regulation of Zbu1, a DNA-binding member of the SWI2/SNF2 family. Dev Biol. 1997 Mar 15; 183(2):166-82.
View in: PubMed

Identification and characterization of neogenin, a DCC-related gene. Oncogene. 1997 Mar 13; 14(10):1129-36.
View in: PubMed

cDNA cloning, tissue distribution, and chromosomal localization of myelodysplasia/myeloid leukemia factor 2 (MLF2). Genomics. 1996 Jul 15; 35(2):392-6.
View in: PubMed

Identification of a region which directs the monocytic activity of the colony-stimulating factor 1 (macrophage colony-stimulating factor) receptor promoter and binds PEBP2/CBF (AML1). Mol Cell Biol. 1994 Dec; 14(12):8085-95.
View in: PubMed

Hematopoietic differentiation antigens that are membrane-associated enzymes: cutting is the key! Blood. 1993 Aug 15; 82(4):1052-70.
View in: PubMed

Germline mutations of the p53 tumor-suppressor gene in children and young adults with second malignant neoplasms. N Engl J Med. 1992 May 14; 326(20):1309-15.
View in: PubMed

The human t(1;19) translocation in pre-B ALL produces multiple nuclear E2A-Pbx1 fusion proteins with differing transforming potentials. Genes Dev. 1991 Mar; 5(3):358-68.
View in: PubMed

Research Departments:

Support My Research

Location

Dana-Farber Cancer Institute
450 Brookline Avenue
Mayer 630
Boston, MA 02215
Get Directions

Top