Skip Navigation

Alejandro Gutierrez, MD, FAAP


Pediatric Hematology/Oncology

Make an Appointment

Physician

  • Physician
  • Associate Professor of Pediatrics, Harvard Medical School

Clinical Interests

  • Global health
  • Liposarcoma
  • T-cell acute lymphoblastic leukemia
  • Zebrafish drug screens

Contact Information

  • Appointments888-733-4662 (new)
    617-632-3270 (established)
  • Office Phone Number617-919-3660
  • Fax617-730-0934

Bio

Dr. Gutierrez received an MD degree from the University of Pennsylvania School of Medicine and completed a pediatrics residency at The Children's Hospital of Philadelphia, followed by a fellowship in pediatric hematology/oncology at Boston Children's Hospital/Dana-Farber Cancer Institute. His postdoctoral research training was with Dr. A. Thomas Look at Dana-Farber Cancer Institute. Dr. Gutierrez is a Scholar of the American Society of Hematology-Harold Amos Medical Faculty Development Program and recipient of the 2010 Young Investigators Award from the American Society of Pediatric Hematology/Oncology.

Board Certification:

  • Pediatric Hematology/Oncology, 2009
  • Pediatrics, 2004

Fellowship:

  • Boston Children's Hospital/Dana-Farber Cancer Institute, Pediatric Hematology/Oncology

Residency:

  • Children's Hospital of Philadelphia, Pediatrics

Medical School:

  • University of Pennsylvania School of Medicine

Recent Awards:

  • Milagras para Niños Award, Boston Children's Hospital, 2019
  • Barry H. Paw Award for Excellence in Teaching, 2018
  • Clinical Investigator Award, Damon Runyon Cancer Research Foundation, 2014
  • Elected Member, Society for Pediatric Research, 2013
  • Young Investigator Award, American Society of Pediatric Hematology/Oncology, 2010
  • American Society of Hematology/Amos Medical Faculty Career Development Award, 2009

Research



The Gutierrez laboratory is focused on discovery of molecular oncogenesis and novel therapeutic targets for chemoresistant human cancers, including high-risk T-cell acute lymphoblastic leukemia and treatment-resistant sarcomas. Our approach combines functional genetics, biochemistry, and small molecule screens, leveraging the zebrafish models of these high-risk human cancers we have recently developed.



Ganglioneuromas are driven by activated AKT and can be therapeutically targeted with mTOR inhibitors. J Exp Med. 2020 10 05; 217(10).
View in: PubMed

Exploiting the Therapeutic Interaction of WNT Pathway Activation and Asparaginase for Colorectal Cancer Therapy. Cancer Discov. 2020 Nov; 10(11):1690-1705.
View in: PubMed

Fanconi-BRCA pathway mutations in childhood T-cell acute lymphoblastic leukemia. PLoS One. 2019; 14(11):e0221288.
View in: PubMed

Synthetic Lethality of Wnt Pathway Activation and Asparaginase in Drug-Resistant Acute Leukemias. Cancer Cell. 2019 04 15; 35(4):664-676.e7.
View in: PubMed

PRC2 loss induces chemoresistance by repressing apoptosis in T cell acute lymphoblastic leukemia. J Exp Med. 2018 12 03; 215(12):3094-3114.
View in: PubMed

JDP2: An oncogenic bZIP transcription factor in T cell acute lymphoblastic leukemia. J Exp Med. 2018 07 02; 215(7):1929-1945.
View in: PubMed

Hedgehog pathway mutations drive oncogenic transformation in high-risk T-cell acute lymphoblastic leukemia. Leukemia. 2018 10; 32(10):2126-2137.
View in: PubMed

An "off-the-shelf" fratricide-resistant CAR-T for the treatment of T cell hematologic malignancies. Leukemia. 2018 09; 32(9):1970-1983.
View in: PubMed

Acute myeloid/T-lymphoblastic leukaemia (AMTL): a distinct category of acute leukaemias with common pathogenesis in need of improved therapy. Br J Haematol. 2018 03; 180(6):919-924.
View in: PubMed

TOX Regulates Growth, DNA Repair, and Genomic Instability in T-cell Acute Lymphoblastic Leukemia. Cancer Discov. 2017 11; 7(11):1336-1353.
View in: PubMed

Inactivation of Capicua in adult mice causes T-cell lymphoblastic lymphoma. Genes Dev. 2017 07 15; 31(14):1456-1468.
View in: PubMed

The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice. Cancer Cell. 2016 07 11; 30(1):183.
View in: PubMed

The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice. Cancer Cell. 2016 04 11; 29(4):574-586.
View in: PubMed

Zebrafish Models of Human Leukemia: Technological Advances and Mechanistic Insights. Adv Exp Med Biol. 2016; 916:335-69.
View in: PubMed

Complete hematologic response of early T-cell progenitor acute lymphoblastic leukemia to the ?-secretase inhibitor BMS-906024: genetic and epigenetic findings in an outlier case. Cold Spring Harb Mol Case Stud. 2015 Oct; 1(1):a000539.
View in: PubMed

A strategy to improve treatment-related mortality and abandonment of therapy for childhood ALL in a developing country reveals the impact of treatment delays. Pediatr Blood Cancer. 2015 Aug; 62(8):1395-402.
View in: PubMed

An X-linked tumor suppressor in T-ALL. Blood. 2015 Jan 01; 125(1):3-4.
View in: PubMed

Oncogene regulation. An oncogenic super-enhancer formed through somatic mutation of a noncoding intergenic element. Science. 2014 Dec 12; 346(6215):1373-7.
View in: PubMed

Cyclin C is a haploinsufficient tumour suppressor. Nat Cell Biol. 2014 Nov; 16(11):1080-91.
View in: PubMed

Thymocyte transformation enhanced. Nat Med. 2014 Oct; 20(10):1096-7.
View in: PubMed

Maturation stage of T-cell acute lymphoblastic leukemia determines BCL-2 versus BCL-XL dependence and sensitivity to ABT-199. Cancer Discov. 2014 Sep; 4(9):1074-87.
View in: PubMed

Letter to the editor: Pseudopapillary tumor of the pancreas in a child with hemihypertrophy and a history of Wilms tumor. Pediatr Blood Cancer. 2014 Oct; 61(10):1901-2.
View in: PubMed

Loss of function tp53 mutations do not accelerate the onset of myc-induced T-cell acute lymphoblastic leukaemia in the zebrafish. Br J Haematol. 2014 Jul; 166(1):84-90.
View in: PubMed

Leukemia propagating cells Akt up. Cancer Cell. 2014 Mar 17; 25(3):263-5.
View in: PubMed

An epigenetic mechanism of resistance to targeted therapy in T cell acute lymphoblastic leukemia. Nat Genet. 2014 Apr; 46(4):364-70.
View in: PubMed

Phenothiazines induce PP2A-mediated apoptosis in T cell acute lymphoblastic leukemia. J Clin Invest. 2014 Feb; 124(2):644-55.
View in: PubMed

c-Myc inhibition prevents leukemia initiation in mice and impairs the growth of relapsed and induction failure pediatric T-ALL cells. Blood. 2014 Feb 13; 123(7):1040-50.
View in: PubMed

Immature MEF2C-dysregulated T-cell leukemia patients have an early T-cell precursor acute lymphoblastic leukemia gene signature and typically have non-rearranged T-cell receptors. Haematologica. 2014 Jan; 99(1):94-102.
View in: PubMed

The TAL1 complex targets the FBXW7 tumor suppressor by activating miR-223 in human T cell acute lymphoblastic leukemia. J Exp Med. 2013 Jul 29; 210(8):1545-57.
View in: PubMed

TYK2-STAT1-BCL2 pathway dependence in T-cell acute lymphoblastic leukemia. Cancer Discov. 2013 May; 3(5):564-77.
View in: PubMed

Inactivation of ribosomal protein L22 promotes transformation by induction of the stemness factor, Lin28B. Blood. 2012 Nov 01; 120(18):3764-73.
View in: PubMed

Core transcriptional regulatory circuit controlled by the TAL1 complex in human T cell acute lymphoblastic leukemia. Cancer Cell. 2012 Aug 14; 22(2):209-21.
View in: PubMed

NOTCH1 signaling promotes human T-cell acute lymphoblastic leukemia initiating cell regeneration in supportive niches. PLoS One. 2012; 7(6):e39725.
View in: PubMed

Aberrant AKT activation drives well-differentiated liposarcoma. Proc Natl Acad Sci U S A. 2011 Sep 27; 108(39):16386-91.
View in: PubMed

The BCL11B tumor suppressor is mutated across the major molecular subtypes of T-cell acute lymphoblastic leukemia. Blood. 2011 Oct 13; 118(15):4169-73.
View in: PubMed

Pten mediates Myc oncogene dependence in a conditional zebrafish model of T cell acute lymphoblastic leukemia. J Exp Med. 2011 Aug 01; 208(8):1595-603.
View in: PubMed

Shared acquired genomic changes in zebrafish and human T-ALL. Oncogene. 2011 Oct 13; 30(41):4289-96.
View in: PubMed

SCF(FBW7) regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction. Nature. 2011 Mar 03; 471(7336):104-9.
View in: PubMed

T-lymphoblastic lymphoma cells express high levels of BCL2, S1P1, and ICAM1, leading to a blockade of tumor cell intravasation. Cancer Cell. 2010 Oct 19; 18(4):353-66.
View in: PubMed

Absence of biallelic TCRgamma deletion predicts early treatment failure in pediatric T-cell acute lymphoblastic leukemia. J Clin Oncol. 2010 Aug 20; 28(24):3816-23.
View in: PubMed

Inactivation of LEF1 in T-cell acute lymphoblastic leukemia. Blood. 2010 Apr 08; 115(14):2845-51.
View in: PubMed

Resolution of cerebral artery stenosis in a child with sickle cell anemia treated with hydroxyurea. Am J Hematol. 2010 Feb; 85(2):135-7.
View in: PubMed

Liquid chromatography-mass spectrometry (LC-MS) of steroid hormone metabolites and its applications. J Steroid Biochem Mol Biol. 2010 Aug; 121(3-5):546-55.
View in: PubMed

Interconnecting molecular pathways in the pathogenesis and drug sensitivity of T-cell acute lymphoblastic leukemia. Blood. 2010 Mar 04; 115(9):1735-45.
View in: PubMed

Emi1 maintains genomic integrity during zebrafish embryogenesis and cooperates with p53 in tumor suppression. Mol Cell Biol. 2009 Nov; 29(21):5911-22.
View in: PubMed

High frequency of PTEN, PI3K, and AKT abnormalities in T-cell acute lymphoblastic leukemia. Blood. 2009 Jul 16; 114(3):647-50.
View in: PubMed

Cell and molecular biology of human leukaemias. Oxford Textbook of Medicine. 2009.

Pathobiology of Acute Lymphoblastic Leukemia. Hematology: Basic Principles and Practice. Editors: Hoffman R et al. 2009.

Alu elements mediate MYB gene tandem duplication in human T-ALL. J Exp Med. 2007 Dec 24; 204(13):3059-66.
View in: PubMed

NOTCH and PI3K-AKT pathways intertwined. Cancer Cell. 2007 Nov; 12(5):411-3.
View in: PubMed

Heat-shock induction of T-cell lymphoma/leukaemia in conditional Cre/lox-regulated transgenic zebrafish. Br J Haematol. 2007 Jul; 138(2):169-75.
View in: PubMed

Chromosomally unstable mouse tumours have genomic alterations similar to diverse human cancers. Nature. 2007 Jun 21; 447(7147):966-71.
View in: PubMed

Liquid chromatography/electron capture atmospheric pressure chemical ionization/mass spectrometry: analysis of pentafluorobenzyl derivatives of biomolecules and drugs in the attomole range. Anal Chem. 2000 Jul 15; 72(14):3007-13.
View in: PubMed

Research Website:

Location

Boston Children's Hospital
300 Longwood Ave.
Boston, MA 02115
Get Directions

Dana-Farber Cancer Institute
450 Brookline Avenue
Boston, MA 02215
Get Directions

Top