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Alexi A. Wright, MD, MPH


Medical Oncology

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Physician

  • Director, Gynecologic Oncology Outcomes Research
  • Physician
  • Assistant Professor of Medicine, Harvard Medical School

Centers/Programs

Clinical Interests

  • Cervical cancer
  • End-of-life care
  • Gynecologic cancers
  • Ovarian cancer
  • Quality of life

Contact Information

  • Appointments617-632-2334
  • Office Phone Number617-632-2334
  • Fax617-632-3479

Bio

Dr. Wright is an Assistant Professor of Medicine at Harvard Medical School and  Dana-Farber Cancer Institute.  She received her Medical Degree from University of Pennsylvania and completed a residency in Internal Medicine at Brigham and Women’s Hospital and a Medical Oncology fellowship at Dana-Farber Cancer Institute.   She also obtained a Masters in Public Health at the Harvard School of Public Health. In 2009 she joined the faculty of Dana-Farber Cancer Institute, where she is a practicing medical oncologist who specializes in gynecologic oncology and health outcomes research. 

Board Certification:

  • Internal Medicine, 2006
  • Medical Oncology, 2009

Fellowship:

  • Dana-Farber/Partners CancerCare, Medical Oncology

Residency:

  • Brigham and Women's Hospital, Internal Medicine

Medical School:

  • University of Pennsylvania School of Medicine

Recent Awards:

  • American Society for Clinical Oncology Career Development Award  2010
  • National Palliative Care Research Center Career Development Award 2010
  • American Cancer Society Mentored Research Scholar Grant 2013
  • National Cancer Institute K07 Career Development Award 2013
  • American Society of Clinical Oncology Young Investigator Award 2009
  • Wellness Community "Outstanding Caregiver Award" 2007
  • Brigham and Women's Hospital's Award for "Distinguished Resident Mentor" 2006
  • Brigham and Women's Hospital's "Dunne Award for Compassionate Clinical Care" 2003

Research

Health services, comparative effectiveness, intervention research, genomics

My research examines the ways that communication between physicians and patients shape advanced cancer patients' understanding of their disease, treatment decisions, and medical outcomes. I am developing interventions to improve patient-physician communication, ensure that patients' care is congruent with their values, and improves patients' quality of life. I also have a specific interest in cervical cancer and examining how genomic alterations influence patient outcomes at a population-level.

Meyer LA, He W, Sun CC, Zhao H, Wright AA, Suidan RS, Dottino J, Alejandro Rauh-Hain J, Lu KH, Giordano SH. Neoadjuvant chemotherapy in elderly women with ovarian cancer: Rates of use and effectiveness. Gynecol Oncol. 2018 Jun 29.
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Markt SC, Tang T, Cronin AM, Katz IT, Howitt BE, Horowitz NS, Lee LJ, Wright AA. Insurance status and cancer treatment mediate the association between race/ethnicity and cervical cancer survival. PLoS One. 2018; 13(2):e0193047.
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Wright AA, Katz IT. Beyond Burnout - Redesigning Care to Restore Meaning and Sanity for Physicians. N Engl J Med. 2018 Jan 25; 378(4):309-311.
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Melamed A, Fink G, Wright AA, Keating NL, Gockley AA, Del Carmen MG, Schorge JO, Rauh-Hain JA. Effect of adoption of neoadjuvant chemotherapy for advanced ovarian cancer on all cause mortality: quasi-experimental study. BMJ. 2018 01 03; 360:j5463.
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Melamed A, Wright AA. Patient Reported Outcomes: Recent Successes and Future Opportunities. Gynecol Oncol. 2018 01; 148(1):1-2.
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Harris JA, Perumalswami CR, Langa KM, Wright AA, Griggs JJ. The Relationship of Obesity to Hospice Use and Expenditures. Ann Intern Med. 2017 10 17; 167(8):605.
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Bober SL, Recklitis CJ, Michaud AL, Wright AA. Improvement in sexual function after ovarian cancer: Effects of sexual therapy and rehabilitation after treatment for ovarian cancer. Cancer. 2018 Jan 01; 124(1):176-182.
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Parikh RB, Wright AA. The Affordable Care Act and End-of-Life Care for Patients With Cancer. Cancer J. 2017 May/Jun; 23(3):190-193.
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Katz IT, Wright AA. Scientific Drought, Golden Eggs, and Global Leadership - Why Trump's NIH Funding Cuts Would Be a Disaster. N Engl J Med. 2017 05 04; 376(18):1701-1704.
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Harris JA, Byhoff E, Perumalswami CR, Langa KM, Wright AA, Griggs JJ. The Relationship of Obesity to Hospice Use and Expenditures: A Cohort Study. Ann Intern Med. 2017 Mar 21; 166(6):381-389.
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Edelson MI, Wright AA. Reply to D. Luvero et al. J Clin Oncol. 2017 Mar; 35(7):802.
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Meyer LA, Wright AA. Reply to M.S. Copur et al. J Clin Oncol. 2017 Mar; 35(7):803.
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Kumar P, Wright AA, Hatfield LA, Temel JS, Keating NL. Family Perspectives on Hospice Care Experiences of Patients with Cancer. J Clin Oncol. 2017 Feb; 35(4):432-439.
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Meyer LA, Cronin AM, Sun CC, Bixel K, Bookman MA, Cristea MC, Griggs JJ, Levenback CF, Burger RA, Mantia-Smaldone G, Matulonis UA, Niland JC, O'Malley DM, Wright AA. Use and Effectiveness of Neoadjuvant Chemotherapy for Treatment of Ovarian Cancer. J Clin Oncol. 2016 Nov 10; 34(32):3854-3863.
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Esselen KM, Cronin AM, Bixel K, Bookman MA, Burger RA, Cohn DE, Cristea M, Griggs JJ, Levenback CF, Mantia-Smaldone G, Meyer LA, Matulonis UA, Niland JC, Sun C, O'Malley DM, Wright AA. Use of CA-125 Tests and Computed Tomographic Scans for Surveillance in Ovarian Cancer. JAMA Oncol. 2016 Nov 01; 2(11):1427-1433.
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Mukamel DB, Cohn DE, Havrilesky L, Wright AA, Lipscomb J, Sparks L, Ladd H, Osann K. Time trade-offs in advanced ovarian cancer. J Clin Oncol. 2016 Oct 09; 34(26_suppl):20.
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Wright AA, Bohlke K, Edelson MI. Neoadjuvant Chemotherapy for Newly Diagnosed Advanced Ovarian Cancer: Society of Gynecologic Oncology and ASCO Clinical Practice Guideline Summary. J Oncol Pract. 2016 Dec; 12(12):1254-1257.
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Markt SC, Lago-Hernandez CA, Miller RE, Mahal BA, Bernard B, Albiges L, Frazier LA, Beard CJ, Wright AA, Sweeney CJ. Insurance status and disparities in disease presentation, treatment, and outcomes for men with germ cell tumors. Cancer. 2016 Oct 15; 122(20):3127-3135.
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Wright AA, Bohlke K, Armstrong DK, Bookman MA, Cliby WA, Coleman RL, Dizon DS, Kash JJ, Meyer LA, Moore KN, Olawaiye AB, Oldham J, Salani R, Sparacio D, Tew WP, Vergote I, Edelson MI. Neoadjuvant chemotherapy for newly diagnosed, advanced ovarian cancer: Society of Gynecologic Oncology and American Society of Clinical Oncology Clinical Practice Guideline. Gynecol Oncol. 2016 10; 143(1):3-15.
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Wright AA, Bohlke K, Armstrong DK, Bookman MA, Cliby WA, Coleman RL, Dizon DS, Kash JJ, Meyer LA, Moore KN, Olawaiye AB, Oldham J, Salani R, Sparacio D, Tew WP, Vergote I, Edelson MI. Neoadjuvant Chemotherapy for Newly Diagnosed, Advanced Ovarian Cancer: Society of Gynecologic Oncology and American Society of Clinical Oncology Clinical Practice Guideline. J Clin Oncol. 2016 Oct 01; 34(28):3460-73.
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Katz IT, Butler LM, Crankshaw TL, Wright AA, Bramhill K, Leone DA, Giddy J, Mould S. Cervical Abnormalities in South African Women Living With HIV With High Screening and Referral Rates. J Glob Oncol. 2016 Dec; 2(6):375-380.
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Wright AA, Keating NL, Ayanian JZ, Chrischilles EA, Kahn KL, Ritchie CS, Weeks JC, Earle CC, Landrum MB. Family Perspectives on Aggressive Cancer Care Near the End of Life. JAMA. 2016 Jan 19; 315(3):284-92.
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Wright AA, Cronin A, O'Malley DM. Reply to G.B. Holt. J Clin Oncol. 2016 Mar 20; 34(9):1016-7.
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Meyer LA, Bohlke K, Wright AA. Postoperative Radiation Therapy for Endometrial Cancer: American Society of Clinical Oncology Clinical Practice Guideline Endorsement of the American Society for Radiation Oncology Evidence-Based Guideline. J Oncol Pract. 2016 Feb; 12(2):182-5.
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Wright AA, Cronin A, Milne DE, Bookman MA, Burger RA, Cohn DE, Cristea MC, Griggs JJ, Keating NL, Levenback CF, Mantia-Smaldone G, Matulonis UA, Meyer LA, Niland JC, Weeks JC, O'Malley DM. Use and Effectiveness of Intraperitoneal Chemotherapy for Treatment of Ovarian Cancer. J Clin Oncol. 2015 Sep 10; 33(26):2841-7.
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Narang AK, Wright AA, Nicholas LH. Trends in Advance Care Planning in Patients With Cancer: Results From a National Longitudinal Survey. JAMA Oncol. 2015 Aug; 1(5):601-8.
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Cohn DE, Havrilesky LJ, Osann K, Lipscomb J, Hsieh S, Walker JL, Wright AA, Alvarez RD, Karlan BY, Bristow RE, DiSilvestro PA, Wakabayashi MT, Morgan R, Mukamel DB, Wenzel L. Consensus in controversy: The modified Delphi method applied to Gynecologic Oncology practice. Gynecol Oncol. 2015 Sep; 138(3):712-6.
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Meyer LA, Bohlke K, Powell MA, Fader AN, Franklin GE, Lee LJ, Matei D, Coallier L, Wright AA. Postoperative Radiation Therapy for Endometrial Cancer: American Society of Clinical Oncology Clinical Practice Guideline Endorsement of the American Society for Radiation Oncology Evidence-Based Guideline. J Clin Oncol. 2015 Sep 10; 33(26):2908-13.
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Horowitz NS, Wright AA. Impact of obesity on chemotherapy management and outcomes in women with gynecologic malignancies. Gynecol Oncol. 2015 Jul; 138(1):201-6.
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Katz IT, Dietrich J, Tshabalala G, Essien T, Rough K, Wright AA, Bangsberg DR, Gray GE, Ware NC. Understanding treatment refusal among adults presenting for HIV-testing in Soweto, South Africa: a qualitative study. AIDS Behav. 2015 Apr; 19(4):704-14.
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Pirl WF, Greer JA, Irwin K, Lennes IT, Jackson VA, Park ER, Fujisawa D, Wright AA, Temel JS. Processes of discontinuing chemotherapy for metastatic non-small-cell lung cancer at the end of life. J Oncol Pract. 2015 May; 11(3):e405-12.
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Greer JA, Irwin K, Lennes IT, Jackson VA, Park ER, Fujisawa D, Wright AA, Temel JS. Processes of discontinuing chemotherapy for metastatic non-small cell lung cancer at the end of life. J Clin Oncol. 2014 Nov; 32(31_suppl):96.
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Salas Coronado D, Watts CD, Wright AA, Abel GA. Quality of end-of-life care: Are blood cancers different? J Clin Oncol. 2014 Oct 20; 32(30_suppl):195.
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Odejide OO, Salas Coronado DY, Watts CD, Wright AA, Abel GA. End-of-life care for blood cancers: a series of focus groups with hematologic oncologists. J Oncol Pract. 2014 Nov; 10(6):e396-403.
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Wright AA, Hatfield LA, Earle CC, Keating NL. End-of-life care for older patients with ovarian cancer is intensive despite high rates of hospice use. J Clin Oncol. 2014 Nov 01; 32(31):3534-9.
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Wright AA, Zhang B, Keating NL, Weeks JC, Prigerson HG. Associations between palliative chemotherapy and adult cancer patients' end of life care and place of death: prospective cohort study. BMJ. 2014 Mar 04; 348:g1219.
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Ojesina AI, Lichtenstein L, Freeman SS, Pedamallu CS, Imaz-Rosshandler I, Pugh TJ, Cherniack AD, Ambrogio L, Cibulskis K, Bertelsen B, Romero-Cordoba S, Treviño V, Vazquez-Santillan K, Guadarrama AS, Wright AA, Rosenberg MW, Duke F, Kaplan B, Wang R, Nickerson E, Walline HM, Lawrence MS, Stewart C, Carter SL, McKenna A, Rodriguez-Sanchez IP, Espinosa-Castilla M, Woie K, Bjorge L, Wik E, Halle MK, Hoivik EA, Krakstad C, Gabiño NB, Gómez-Macías GS, Valdez-Chapa LD, Garza-Rodríguez ML, Maytorena G, Vazquez J, Rodea C, Cravioto A, Cortes ML, Greulich H, Crum CP, Neuberg DS, Hidalgo-Miranda A, Escareno CR, Akslen LA, Carey TE, Vintermyr OK, Gabriel SB, Barrera-Saldaña HA, Melendez-Zajgla J, Getz G, Salvesen HB, Meyerson M. Landscape of genomic alterations in cervical carcinomas. Nature. 2014 Feb 20; 506(7488):371-5.
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Katz IT, Bassett IV, Wright AA. PEPFAR in transition--implications for HIV care in South Africa. N Engl J Med. 2013 Oct 10; 369(15):1385-7.
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Krishnan MS, Epstein-Peterson Z, Chen YH, Tseng YD, Wright AA, Temel JS, Catalano P, Balboni TA. Predicting life expectancy in patients with metastatic cancer receiving palliative radiotherapy: the TEACHH model. Cancer. 2014 Jan 01; 120(1):134-41.
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Katz IT, Nkala B, Dietrich J, Wallace M, Bekker LG, Pollenz K, Bogart LM, Wright AA, Tsai AC, Bangsberg DR, Gray GE. A qualitative analysis of factors influencing HPV vaccine uptake in Soweto, South Africa among adolescents and their caregivers. PLoS One. 2013; 8(8):e72094.
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Wright AA, Howitt BE, Myers AP, Dahlberg SE, Palescandolo E, Van Hummelen P, MacConaill LE, Shoni M, Wagle N, Jones RT, Quick CM, Laury A, Katz IT, Hahn WC, Matulonis UA, Hirsch MS. Oncogenic mutations in cervical cancer: genomic differences between adenocarcinomas and squamous cell carcinomas of the cervix. Cancer. 2013 Nov 01; 119(21):3776-83.
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Dizon DS, Ambrosio AJ, Feltmate C, Wright AA, Campos SM, Viswanathan A. Pushing the bar in treatment of cervical cancer: what can comprehensive cancer centers do on their own? Gynecol Oncol. 2013 Nov; 131(2):464-6.
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Krishnan M, Temel JS, Wright AA, Bernacki R, Selvaggi K, Balboni T. Predicting life expectancy in patients with advanced incurable cancer: a review. J Support Oncol. 2013 Jun; 11(2):68-74.
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Wright AA, Stieglitz H, Kupersztoch YM, Paulk ME, Kim Y, Katz IT, Munoz F, Jimenez RB, Mutchler J, Rivera L, Back AL, Prigerson HG. United states acculturation and cancer patients' end-of-life care. PLoS One. 2013; 8(3):e58663.
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Shoni M, Parra-Herran CE, May T, Wright AA, Feltmate CM. Multiple synchronous primary gynecologic malignancies in an MSH2 mutation carrier with endometriosis. J Clin Oncol. 2013 Jan 20; 31(3):e33-6.
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Gao X, Prigerson HG, Diamond EL, Zhang B, Wright AA, Meyer F, Maciejewski PK. Minor cognitive impairments in cancer patients magnify the effect of caregiver preferences on end-of-life care. J Pain Symptom Manage. 2013 Apr; 45(4):650-9.
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Maciejewski PK, Phelps AC, Kacel EL, Balboni TA, Balboni M, Wright AA, Pirl W, Prigerson HG. Religious coping and behavioral disengagement: opposing influences on advance care planning and receipt of intensive care near death. Psychooncology. 2012 Jul; 21(7):714-23.
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Wright AA, Cook CE, Flynn TW, Baxter GD, Abbott JH. Predictors of response to physical therapy intervention in patients with primary hip osteoarthritis. Phys Ther. 2011 Apr; 91(4):510-24.
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Wright AA, Mack JW, Kritek PA, Balboni TA, Massaro AF, Matulonis UA, Block SD, Prigerson HG. Influence of patients' preferences and treatment site on cancer patients' end-of-life care. Cancer. 2010 Oct 01; 116(19):4656-63.
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Wright AA, Keating NL, Balboni TA, Matulonis UA, Block SD, Prigerson HG. Place of death: correlations with quality of life of patients with cancer and predictors of bereaved caregivers' mental health. J Clin Oncol. 2010 Oct 10; 28(29):4457-64.
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Alcorn SR, Balboni MJ, Prigerson HG, Reynolds A, Phelps AC, Wright AA, Block SD, Peteet JR, Kachnic LA, Balboni TA. "If God wanted me yesterday, I wouldn't be here today": religious and spiritual themes in patients' experiences of advanced cancer. J Palliat Med. 2010 May; 13(5):581-8.
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Mack JW, Weeks JC, Wright AA, Block SD, Prigerson HG. End-of-life discussions, goal attainment, and distress at the end of life: predictors and outcomes of receipt of care consistent with preferences. J Clin Oncol. 2010 Mar 01; 28(7):1203-8.
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Balboni TA, Paulk ME, Balboni MJ, Phelps AC, Loggers ET, Wright AA, Block SD, Lewis EF, Peteet JR, Prigerson HG. Provision of spiritual care to patients with advanced cancer: associations with medical care and quality of life near death. J Clin Oncol. 2010 Jan 20; 28(3):445-52.
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Loggers ET, Maciejewski PK, Paulk E, DeSanto-Madeya S, Nilsson M, Viswanath K, Wright AA, Balboni TA, Temel J, Stieglitz H, Block S, Prigerson HG. Racial differences in predictors of intensive end-of-life care in patients with advanced cancer. J Clin Oncol. 2009 Nov 20; 27(33):5559-64.
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Phelps AC, Maciejewski PK, Nilsson M, Balboni TA, Wright AA, Paulk ME, Trice E, Schrag D, Peteet JR, Block SD, Prigerson HG. Religious coping and use of intensive life-prolonging care near death in patients with advanced cancer. JAMA. 2009 Mar 18; 301(11):1140-7.
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Zhang B, Wright AA, Huskamp HA, Nilsson ME, Maciejewski ML, Earle CC, Block SD, Maciejewski PK, Prigerson HG. Health care costs in the last week of life: associations with end-of-life conversations. Arch Intern Med. 2009 Mar 09; 169(5):480-8.
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Nilsson ME, Maciejewski PK, Zhang B, Wright AA, Trice ED, Muriel AC, Friedlander RJ, Fasciano KM, Block SD, Prigerson HG. Mental health, treatment preferences, advance care planning, location, and quality of death in advanced cancer patients with dependent children. Cancer. 2009 Jan 15; 115(2):399-409.
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Katz IT, Wright AA. Circumcision--a surgical strategy for HIV prevention in Africa. N Engl J Med. 2008 Dec 04; 359(23):2412-5.
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Wright AA, Zhang B, Ray A, Mack JW, Trice E, Balboni T, Mitchell SL, Jackson VA, Block SD, Maciejewski PK, Prigerson HG. Associations between end-of-life discussions, patient mental health, medical care near death, and caregiver bereavement adjustment. JAMA. 2008 Oct 08; 300(14):1665-73.
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Wright AA, Katz IT. Letting go of the rope--aggressive treatment, hospice care, and open access. N Engl J Med. 2007 Jul 26; 357(4):324-7.
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Wright AA, Katz IT. Tobacco tightrope--balancing disease prevention and economic development in China. N Engl J Med. 2007 Apr 12; 356(15):1493-6.
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Wright AA, Katz IT. Roe versus reality--abortion and women's health. N Engl J Med. 2006 Jul 06; 355(1):1-9.
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Katz IT, Wright AA. Preventing cervical cancer in the developing world. N Engl J Med. 2006 Mar 16; 354(11):1110.
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Wright AA, Katz IT. Home testing for HIV. N Engl J Med. 2006 Feb 02; 354(5):437-40.
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Wright AA, Katz IT. Bar coding for patient safety. N Engl J Med. 2005 Jul 28; 353(4):329-31.
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Katz IT, Wright AA. Collateral damage--Médecins sans Frontières leaves Afghanistan and Iraq. N Engl J Med. 2004 Dec 16; 351(25):2571-3.
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Wright AA, Katz IT. Match point? N Engl J Med. 2004 Sep 16; 351(12):1165-7.
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Research Departments:

Location

Dana-Farber Cancer Institute
450 Brookline Avenue
Boston MA, 02215
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