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Charlotta Lindvall, MD, PhD


Palliative Medicine

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Physician

  • Physician
  • Instructor in Medicine, Harvard Medical School

Centers/Programs

Contact Information

  • Office Phone Number617-632-6464

Board Certification:

  • Hospice and Palliative Medicine
  • Internal Medicine

Fellowship:

  • Dana-Farber Cancer Institute and Massachusetts General Hospital Palliative Care

Residency:

  • MSU College of Human Medicine

Medical School:

  • Karolinska Institutet, Stockholm, Sweden

Research

Agaronnik N, Lindvall C, El-Jawahri A, He W, Iezzoni L. Use of Natural Language Processing to Assess Frequency of Functional Status Documentation for Patients Newly Diagnosed With Colorectal Cancer. JAMA Oncol. 2020 Sep 03.
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Lee RY, Brumback LC, Lober WB, Sibley J, Nielsen EL, Treece PD, Kross EK, Loggers ET, Fausto JA, Lindvall C, Engelberg RA, Curtis JR. Identifying Goals of Care Conversations in the Electronic Health Record Using Natural Language Processing and Machine Learning. J Pain Symptom Manage. 2020 Aug 25.
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O'Hanlon CE, Lindvall C, Lorenz KA, Giannitrapani KF, Garrido M, Asch SM, Wenger N, Malin J, Dy SM, Canning M, Gamboa RC, Walling AM. Measure Scan and Synthesis of Palliative and End-of-Life Process Quality Measures for Advanced Cancer. JCO Oncol Pract. 2020 Aug 06; OP2000240.
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Lakin JR, Brannen EN, Tulsky JA, Paasche-Orlow MK, Lindvall C, Chang Y, Gundersen DA, El-Jawahri A, Volandes A. Advance Care Planning: Promoting Effective and Aligned Communication in the Elderly (ACP-PEACE): the study protocol for a pragmatic stepped-wedge trial of older patients with cancer. BMJ Open. 2020 07 14; 10(7):e040999.
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O'Hanlon CE, Walling AM, Lindvall C. Shortlist of Quality Indicators for End-of-Life Cancer Care. JAMA Oncol. 2020 Jul 01; 6(7):1118-1119.
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Geerse OP, Lamas DJ, Bernacki RE, Sanders JJ, Paladino J, Berendsen AJ, Hiltermann TJN, Lindvall C, Fromme EK, Block SD. Adherence and Concordance between Serious Illness Care Planning Conversations and Oncology Clinician Documentation among Patients with Advanced Cancer. J Palliat Med. 2020 Jun 22.
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Leiter RE, Santus E, Jin Z, Lee KC, Yusufov M, Chien I, Ramaswamy A, Moseley ET, Qian Y, Schrag D, Lindvall C. Deep Natural Language Processing to Identify Symptom Documentation in Clinical Notes for Patients With Heart Failure Undergoing Cardiac Resynchronization Therapy. J Pain Symptom Manage. 2020 Jun 22.
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DeCamp M, Lindvall C. Latent bias and the implementation of artificial intelligence in medicine. J Am Med Inform Assoc. 2020 Jun 18.
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Ouchi K, Lo Bello J, Moseley E, Lindvall C. Long-Term Prognosis of Older Adults Who Survive Emergency Mechanical Ventilation. J Pain Symptom Manage. 2020 Jun 12.
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Agaronnik ND, Lindvall C, El-Jawahri A, He W, Iezzoni LI. Challenges of Developing a Natural Language Processing Method With Electronic Health Records to Identify Persons With Chronic Mobility Disability. Arch Phys Med Rehabil. 2020 Oct; 101(10):1739-1746.
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Waring J, Lindvall C, Umeton R. Automated machine learning: Review of the state-of-the-art and opportunities for healthcare. Artif Intell Med. 2020 04; 104:101822.
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Udelsman BV, Moseley ET, Sudore RL, Keating NL, Lindvall C. Deep Natural Language Processing Identifies Variation in Care Preference Documentation. J Pain Symptom Manage. 2020 Jun; 59(6):1186-1194.e3.
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Brizzi K, Zupanc SN, Udelsman BV, Tulsky JA, Wright AA, Poort H, Lindvall C. Natural Language Processing to Assess Palliative Care and End-of-Life Process Measures in Patients With Breast Cancer With Leptomeningeal Disease. Am J Hosp Palliat Care. 2020 May; 37(5):371-376.
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Hu SY, Santus E, Forsyth AW, Malhotra D, Haimson J, Chatterjee NA, Kramer DB, Barzilay R, Tulsky JA, Lindvall C. Can machine learning improve patient selection for cardiac resynchronization therapy? PLoS One. 2019; 14(10):e0222397.
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Udelsman BV, Lee KC, Lilley EJ, Chang DC, Lindvall C, Cooper Z. Variation in Serious Illness Communication among Surgical Patients Receiving Palliative Care. J Palliat Med. 2020 03; 23(3):411-414.
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Sanders JJ, Berrier AI, Nshuti L, Tulsky JA, Lindvall C. Differences by Race, Religiosity, and Mental Health in Preferences for Life-Prolonging Treatment Among Medicare Beneficiaries. J Gen Intern Med. 2019 10; 34(10):1981-1983.
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Lee KC, Udelsman BV, Streid J, Chang DC, Salim A, Livingston DH, Lindvall C, Cooper Z. Natural Language Processing Accurately Measures Adherence to Best Practice Guidelines for Palliative Care in Trauma. J Pain Symptom Manage. 2020 02; 59(2):225-232.e2.
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Udelsman BV, Lilley EJ, Qadan M, Chang DC, Lillemoe KD, Lindvall C, Cooper Z. Deficits in the Palliative Care Process Measures in Patients with Advanced Pancreatic Cancer Undergoing Operative and Invasive Nonoperative Palliative Procedures. Ann Surg Oncol. 2019 Dec; 26(13):4204-4212.
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Poort H, Zupanc SN, Leiter RE, Wright AA, Lindvall C. Documentation of Palliative and End-of-Life Care Process Measures Among Young Adults Who Died of Cancer: A Natural Language Processing Approach. J Adolesc Young Adult Oncol. 2020 02; 9(1):100-104.
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Udelsman B, Lee K, Qadan M, Lillemoe KD, Chang D, Lindvall C, Cooper Z. Management of Pneumoperitoneum: Role and Limits of Nonoperative Treatment. Ann Surg. 2019 Jul 23.
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Chua IS, Leiter RE, Brizzi KT, Coey CA, Mazzola E, Tulsky JA, Lindvall C. US National Trends in Opioid-Related Hospitalizations Among Patients With Cancer. JAMA Oncol. 2019 May 01; 5(5):734-735.
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Udelsman BV, Corey KE, Lindvall C, Gee DW, Meireles OR, Hutter MM, Chang DC, Witkowski ER. Risk factors and prevalence of liver disease in review of 2557 routine liver biopsies performed during bariatric surgery. Surg Obes Relat Dis. 2019 Jun; 15(6):843-849.
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Ouchi K, George N, Schuur JD, Aaronson EL, Lindvall C, Bernstein E, Sudore RL, Schonberg MA, Block SD, Tulsky JA. Goals-of-Care Conversations for Older Adults With Serious Illness in the Emergency Department: Challenges and Opportunities. Ann Emerg Med. 2019 08; 74(2):276-284.
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Lindvall C, Udelsman B, Malhotra D, Brovman EY, Urman RD, D'Alessandro DA, Tulsky JA. In-hospital mortality in older patients after ventricular assist device implantation: A national cohort study. J Thorac Cardiovasc Surg. 2019 08; 158(2):466-475.e4.
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Chan A, Chien I, Moseley E, Salman S, Kaminer Bourland S, Lamas D, Walling AM, Tulsky JA, Lindvall C. Deep learning algorithms to identify documentation of serious illness conversations during intensive care unit admissions. Palliat Med. 2019 02; 33(2):187-196.
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Lindvall C, Lilley EJ, Zupanc SN, Chien I, Udelsman BV, Walling A, Cooper Z, Tulsky JA. Natural Language Processing to Assess End-of-Life Quality Indicators in Cancer Patients Receiving Palliative Surgery. J Palliat Med. 2019 02; 22(2):183-187.
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Udelsman B, Chien I, Ouchi K, Brizzi K, Tulsky JA, Lindvall C. Needle in a Haystack: Natural Language Processing to Identify Serious Illness. J Palliat Med. 2019 02; 22(2):179-182.
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Ouchi K, Lindvall C, Chai PR, Boyer EW. Machine Learning to Predict, Detect, and Intervene Older Adults Vulnerable for Adverse Drug Events in the Emergency Department. J Med Toxicol. 2018 09; 14(3):248-252.
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Brovman EY, Walsh EC, Burton BN, Kuo CE, Lindvall C, Gabriel RA, Urman RD. Postoperative outcomes in patients with a do-not-resuscitate (DNR) order undergoing elective procedures. J Clin Anesth. 2018 Aug; 48:81-88.
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Lilley EJ, Lindvall C, Lillemoe KD, Tulsky JA, Wiener DC, Cooper Z. Measuring Processes of Care in Palliative Surgery: A Novel Approach Using Natural Language Processing. Ann Surg. 2018 05; 267(5):823-825.
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Forsyth AW, Barzilay R, Hughes KS, Lui D, Lorenz KA, Enzinger A, Tulsky JA, Lindvall C. Machine Learning Methods to Extract Documentation of Breast Cancer Symptoms From Electronic Health Records. J Pain Symptom Manage. 2018 06; 55(6):1492-1499.
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Urman RD, Lilley EJ, Changala M, Lindvall C, Hepner DL, Bader AM. A Pilot Study to Evaluate Compliance with Guidelines for Preprocedural Reconsideration of Code Status Limitations. J Palliat Med. 2018 08; 21(8):1152-1156.
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Curtis JR, Sathitratanacheewin S, Starks H, Lee RY, Kross EK, Downey L, Sibley J, Lober W, Loggers ET, Fausto JA, Lindvall C, Engelberg RA. Using Electronic Health Records for Quality Measurement and Accountability in Care of the Seriously Ill: Opportunities and Challenges. J Palliat Med. 2018 03; 21(S2):S52-S60.
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Zehm A, Lindvall C, Parks K, Schaefer K, Chittenden E. Prognosis, Communication, and Advance Care Planning in Heart Failure: A Module for Students, Residents, Fellows, and Practicing Clinicians. MedEdPORTAL. 2017 Jun 16; 13:10596.
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Chatterjee NA, Borgquist R, Chang Y, Lewey J, Jackson VA, Singh JP, Metlay JP, Lindvall C. Increasing sex differences in the use of cardiac resynchronization therapy with or without implantable cardioverter-defibrillator. Eur Heart J. 2017 May 14; 38(19):1485-1494.
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Zhang H, Barysauskas C, Rickerson E, Catalano P, Jacobson J, Dalby C, Lindvall C, Selvaggi K. The Intensive Palliative Care Unit: Changing Outcomes for Hospitalized Cancer Patients in an Academic Medical Center. J Palliat Med. 2017 03; 20(3):285-289.
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Lindvall C, Chatterjee NA, Chang Y, Chernack B, Jackson VA, Singh JP, Metlay JP. National Trends in the Use of Cardiac Resynchronization Therapy With or Without Implantable Cardioverter-Defibrillator. Circulation. 2016 Jan 19; 133(3):273-81.
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Rickerson E, Barysauskas C, Catalano PJ, Jacobson JO, Dalby CK, Lindvall C, Selvaggi KJ. The Intensive Palliative Care Unit (IPCU): Changing outcomes for hospitalized cancer patients in an academic medical center. J Clin Oncol. 2015 Oct 10; 33(29_suppl):135.
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Jacobsen J, Whitlock SN, Lee H, Lindvall C, Jackson V. Teaching colleagues how to discuss prognosis as part of a hospital-wide quality improvement project: the positive impact of a 90-minute workshop. J Pain Symptom Manage. 2015 May; 49(5):960-3.
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Lindvall C, Hultman TD, Jackson VA. Overcoming the barriers to palliative care referral for patients with advanced heart failure. J Am Heart Assoc. 2014 Feb 28; 3(1):e000742.
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Liu Z, Li Q, Li K, Chen L, Li W, Hou M, Liu T, Yang J, Lindvall C, Björkholm M, Jia J, Xu D. Telomerase reverse transcriptase promotes epithelial-mesenchymal transition and stem cell-like traits in cancer cells. Oncogene. 2013 Sep 05; 32(36):4203-13.
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Wan M, Li J, Herbst K, Zhang J, Yu B, Wu X, Qiu T, Lei W, Lindvall C, Williams BO, Ma H, Zhang F, Cao X. LRP6 mediates cAMP generation by G protein-coupled receptors through regulating the membrane targeting of Ga(s). Sci Signal. 2011 Mar 15; 4(164):ra15.
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Diegel CR, Cho KR, El-Naggar AK, Williams BO, Lindvall C. Mammalian target of rapamycin-dependent acinar cell neoplasia after inactivation of Apc and Pten in the mouse salivary gland: implications for human acinic cell carcinoma. Cancer Res. 2010 Nov 15; 70(22):9143-52.
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Badders NM, Goel S, Clark RJ, Klos KS, Kim S, Bafico A, Lindvall C, Williams BO, Alexander CM. The Wnt receptor, Lrp5, is expressed by mouse mammary stem cells and is required to maintain the basal lineage. PLoS One. 2009 Aug 12; 4(8):e6594.
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Lindvall C, Zylstra CR, Evans N, West RA, Dykema K, Furge KA, Williams BO. The Wnt co-receptor Lrp6 is required for normal mouse mammary gland development. PLoS One. 2009 Jun 05; 4(6):e5813.
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Zylstra CR, Wan C, VanKoevering KK, Sanders AK, Lindvall C, Clemens TL, Williams BO. Gene targeting approaches in mice: assessing the roles of LRP5 and LRP6 in osteoblasts. J Musculoskelet Neuronal Interact. 2008 Oct-Dec; 8(4):291-3.
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Bonte D, Lindvall C, Liu H, Dykema K, Furge K, Weinreich M. Cdc7-Dbf4 kinase overexpression in multiple cancers and tumor cell lines is correlated with p53 inactivation. Neoplasia. 2008 Sep; 10(9):920-31.
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Lindvall C, Bu W, Williams BO, Li Y. Wnt signaling, stem cells, and the cellular origin of breast cancer. Stem Cell Rev. 2007 Jun; 3(2):157-68.
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Hjortsberg L, Lindvall C, Corcoran M, Arulampalam V, Chan D, Thyrell L, Nordenskjold M, Grandér D, Pokrovskaja K. Phosphoinositide 3-kinase regulates a subset of interferon-alpha-stimulated genes. Exp Cell Res. 2007 Jan 15; 313(2):404-14.
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Lindvall C, Evans NC, Zylstra CR, Li Y, Alexander CM, Williams BO. The Wnt signaling receptor Lrp5 is required for mammary ductal stem cell activity and Wnt1-induced tumorigenesis. J Biol Chem. 2006 Nov 17; 281(46):35081-7.
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Inoki K, Ouyang H, Zhu T, Lindvall C, Wang Y, Zhang X, Yang Q, Bennett C, Harada Y, Stankunas K, Wang CY, He X, MacDougald OA, You M, Williams BO, Guan KL. TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth. Cell. 2006 Sep 08; 126(5):955-68.
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Chen F, Liu C, Lindvall C, Xu D, Ernberg I. Epstein-Barr virus latent membrane 2A (LMP2A) down-regulates telomerase reverse transcriptase (hTERT) in epithelial cell lines. Int J Cancer. 2005 Jan 10; 113(2):284-9.
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Lindvall C, Furge K, Björkholm M, Guo X, Haab B, Blennow E, Nordenskjöld M, Teh BT. Combined genetic and transcriptional profiling of acute myeloid leukemia with normal and complex karyotypes. Haematologica. 2004 Sep; 89(9):1072-81.
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Poppe B, Vandesompele J, Schoch C, Lindvall C, Mrozek K, Bloomfield CD, Beverloo HB, Michaux L, Dastugue N, Herens C, Yigit N, De Paepe A, Hagemeijer A, Speleman F. Expression analyses identify MLL as a prominent target of 11q23 amplification and support an etiologic role for MLL gain of function in myeloid malignancies. Blood. 2004 Jan 01; 103(1):229-35.
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Lindvall C, Hou M, Komurasaki T, Zheng C, Henriksson M, Sedivy JM, Björkholm M, Teh BT, Nordenskjöld M, Xu D. Molecular characterization of human telomerase reverse transcriptase-immortalized human fibroblasts by gene expression profiling: activation of the epiregulin gene. Cancer Res. 2003 Apr 15; 63(8):1743-7.
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Zhang A, Zheng C, Hou M, Lindvall C, Li KJ, Erlandsson F, Björkholm M, Gruber A, Blennow E, Xu D. Deletion of the telomerase reverse transcriptase gene and haploinsufficiency of telomere maintenance in Cri du chat syndrome. Am J Hum Genet. 2003 Apr; 72(4):940-8.
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Panagopoulos I, Isaksson M, Lindvall C, Hagemeijer A, Mitelman F, Johansson B. Genomic characterization of MOZ/CBP and CBP/MOZ chimeras in acute myeloid leukemia suggests the involvement of a damage-repair mechanism in the origin of the t(8;16)(p11;p13). Genes Chromosomes Cancer. 2003 Jan; 36(1):90-8.
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Zhang A, Zheng C, Hou M, Lindvall C, Wallin KL, Angström T, Yang X, Hellström AC, Blennow E, Björkholm M, Zetterberg A, Gruber A, Xu D. Amplification of the telomerase reverse transcriptase (hTERT) gene in cervical carcinomas. Genes Chromosomes Cancer. 2002 Jul; 34(3):269-75.
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Castaños-Vélez E, Heiden T, Lindvall C, Capello D, Sandlund A, Imreh S, Blennow E, Andersson LC, Gaidano G, Nordenskjöld M, Biberfeld P. Simian AIDS-related lymphoma growth in severe combined immunodeficiency mice is independent of karyotypic abnormalities or Bcl-6 mutations. AIDS Res Hum Retroviruses. 2002 Mar 20; 18(5):383-90.
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Lindvall C, Nordenskjöld M, Porwit A, Björkholm M, Blennow E. Molecular cytogenetic characterization of acute myeloid leukemia and myelodysplastic syndromes with multiple chromosome rearrangements. Haematologica. 2001 Nov; 86(11):1158-64.
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Zhang A, Zheng C, Lindvall C, Hou M, Ekedahl J, Lewensohn R, Yan Z, Yang X, Henriksson M, Blennow E, Nordenskjöld M, Zetterberg A, Björkholm M, Gruber A, Xu D. Frequent amplification of the telomerase reverse transcriptase gene in human tumors. Cancer Res. 2000 Nov 15; 60(22):6230-5.
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Panagopoulos I, Isaksson M, Lindvall C, Björkholm M, Ahlgren T, Fioretos T, Heim S, Mitelman F, Johansson B. RT-PCR analysis of the MOZ-CBP and CBP-MOZ chimeric transcripts in acute myeloid leukemias with t(8;16)(p11;p13). Genes Chromosomes Cancer. 2000 Aug; 28(4):415-24.
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Location

Dana-Farber Cancer Institute
450 Brookline Avenue
Boston, MA 02215
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