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Dipanjan Chowdhury, PhD


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Dipanjan Chowdhury, PhD

Researcher

  • Svanberg Family Chair
  • Professor of Radiation Oncology, Harvard Medical School

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Research

CCAR2 functions downstream of the Shieldin complex to promote double-strand break end-joining. Proc Natl Acad Sci U S A. 2022 12 06; 119(49):e2214935119.
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Targeting replication stress in cancer therapy. Nat Rev Drug Discov. 2023 01; 22(1):38-58.
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A druggable addiction to de novo pyrimidine biosynthesis in diffuse midline glioma. Cancer Cell. 2022 09 12; 40(9):957-972.e10.
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TOPBPing up DSBs with PARylation. Mol Cell. 2022 07 21; 82(14):2538-2540.
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A Translational Model to Improve Early Detection of Epithelial Ovarian Cancers. Front Oncol. 2022; 12:786154.
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Combined PARP and HSP90 inhibition: preclinical and Phase 1 evaluation in patients with advanced solid tumours. Br J Cancer. 2022 04; 126(7):1027-1036.
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MicroRNA profiling in a case-control study of African American women with uterine serous carcinoma. Gynecol Oncol. 2021 12; 163(3):453-458.
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A Replication stress biomarker is associated with response to gemcitabine versus combined gemcitabine and ATR inhibitor therapy in ovarian cancer. Nat Commun. 2021 09 22; 12(1):5574.
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ASTE1 cutting to block DNA end resection. Nat Cell Biol. 2021 08; 23(8):818-819.
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TIRR inhibits the 53BP1-p53 complex to alter cell-fate programs. Mol Cell. 2021 06 17; 81(12):2583-2595.e6.
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Correction to: A prototypical non-malignant epithelial model to study genome dynamics and concurrently monitor micro-RNAs and proteins in situ during oncogene-induced senescence. BMC Genomics. 2021 May 05; 22(1):327.
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CHK1 Inhibitor Blocks Phosphorylation of FAM122A and Promotes Replication Stress. Mol Cell. 2020 11 05; 80(3):410-422.e6.
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Tumor protein expression of the DNA repair gene BRCA1 and lethal prostate cancer. Carcinogenesis. 2020 07 14; 41(7):904-908.
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Berzosertib plus gemcitabine versus gemcitabine alone in platinum-resistant high-grade serous ovarian cancer: a multicentre, open-label, randomised, phase 2 trial. Lancet Oncol. 2020 07; 21(7):957-968.
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Author Correction: Immunogenomic profiling determines responses to combined PARP and PD-1 inhibition in ovarian cancer. Nat Commun. 2020 05 18; 11(1):2543.
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Endogenous oxidized DNA bases and APE1 regulate the formation of G-quadruplex structures in the genome. Proc Natl Acad Sci U S A. 2020 05 26; 117(21):11409-11420.
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Immunogenomic profiling determines responses to combined PARP and PD-1 inhibition in ovarian cancer. Nat Commun. 2020 03 19; 11(1):1459.
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A systemic approach to screening high-throughput RT-qPCR data for a suitable set of reference circulating miRNAs. BMC Genomics. 2020 Jan 31; 21(1):111.
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TRIP13 regulates DNA repair pathway choice through REV7 conformational change. Nat Cell Biol. 2020 01; 22(1):87-96.
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CDK phosphorylation of TRF2 controls t-loop dynamics during the cell cycle. Nature. 2019 11; 575(7783):523-527.
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Circulating microRNAs as Biomarkers of Radiation Exposure: A Systematic Review and Meta-Analysis. Int J Radiat Oncol Biol Phys. 2020 02 01; 106(2):390-402.
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A mitotic CDK5-PP4 phospho-signaling cascade primes 53BP1 for DNA repair in G1. Nat Commun. 2019 09 18; 10(1):4252.
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Identification of LIMK2 as a therapeutic target in castration resistant prostate cancer. Cancer Lett. 2019 04 28; 448:182-196.
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DYNLL1 binds to MRE11 to limit DNA end resection in BRCA1-deficient cells. Nature. 2018 11; 563(7732):522-526.
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Mechanism of 53BP1 activity regulation by RNA-binding TIRR and a designer protein. Nat Struct Mol Biol. 2018 07; 25(7):591-600.
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Potential of serum microRNAs as biomarkers of radiation injury and tools for individualization of radiotherapy. Transl Res. 2018 11; 201:71-83.
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Dual HDAC and PI3K Inhibition Abrogates NF?B- and FOXM1-Mediated DNA Damage Response to Radiosensitize Pediatric High-Grade Gliomas. Cancer Res. 2018 07 15; 78(14):4007-4021.
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Multifaceted Impact of MicroRNA 493-5p on Genome-Stabilizing Pathways Induces Platinum and PARP Inhibitor Resistance in BRCA2-Mutated Carcinomas. Cell Rep. 2018 04 03; 23(1):100-111.
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Mutational signatures reveal the role of RAD52 in p53-independent p21-driven genomic instability. Genome Biol. 2018 03 16; 19(1):37.
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Serum microRNAs - potent biomarkers for radiation biodosimetry. Oncotarget. 2018 Mar 06; 9(18):14038-14039.
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EWS/FLI Confers Tumor Cell Synthetic Lethality to CDK12 Inhibition in Ewing Sarcoma. Cancer Cell. 2018 02 12; 33(2):202-216.e6.
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A prototypical non-malignant epithelial model to study genome dynamics and concurrently monitor micro-RNAs and proteins in situ during oncogene-induced senescence. BMC Genomics. 2018 01 10; 19(1):37.
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Diagnostic potential for a serum miRNA neural network for detection of ovarian cancer. Elife. 2017 10 31; 6.
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TIRR and 53BP1- partners in arms. Cell Cycle. 2017 07 03; 16(13):1235-1236.
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Evolutionarily conserved serum microRNAs predict radiation-induced fatality in nonhuman primates. Sci Transl Med. 2017 03 01; 9(379).
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TIRR regulates 53BP1 by masking its histone methyl-lysine binding function. Nature. 2017 03 09; 543(7644):211-216.
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Clear cell ovarian cancers with microsatellite instability: A unique subset of ovarian cancers with increased tumor-infiltrating lymphocytes and PD-1/PD-L1 expression. Oncoimmunology. 2017; 6(2):e1277308.
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334 A Functional Screen Identifies miRNAs that Induce Radioresistance in Glioblastomas. Neurosurgery. 2016 Aug; 63 Suppl 1:197-8.
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Circulating miR-29a and miR-150 correlate with delivered dose during thoracic radiation therapy for non-small cell lung cancer. Radiat Oncol. 2016 Apr 27; 11:61.
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Association and prognostic significance of BRCA1/2-mutation status with neoantigen load, number of tumor-infiltrating lymphocytes and expression of PD-1/PD-L1 in high grade serous ovarian cancer. Oncotarget. 2016 Mar 22; 7(12):13587-98.
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Platinum and PARP Inhibitor Resistance Due to Overexpression of MicroRNA-622 in BRCA1-Mutant Ovarian Cancer. Cell Rep. 2016 Jan 26; 14(3):429-439.
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Serum microRNAs are early indicators of survival after radiation-induced hematopoietic injury. Sci Transl Med. 2015 May 13; 7(287):287ra69.
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Emerging role of protein phosphatases changes the landscape of phospho-signaling in DNA damage response. DNA Repair (Amst). 2015 Aug; 32:58-65.
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A functional screen identifies miRs that induce radioresistance in glioblastomas. Mol Cancer Res. 2014 Dec; 12(12):1767-78.
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Phosphorylated RPA recruits PALB2 to stalled DNA replication forks to facilitate fork recovery. J Cell Biol. 2014 Aug 18; 206(4):493-507.
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A genome-wide miRNA screen revealed miR-603 as a MGMT-regulating miRNA in glioblastomas. Oncotarget. 2014 Jun 30; 5(12):4026-39.
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KAP-1 promotes resection of broken DNA ends not protected by ?-H2AX and 53BP1 in G1-phase lymphocytes. Mol Cell Biol. 2014 Aug; 34(15):2811-21.
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Sublethal concentrations of 17-AAG suppress homologous recombination DNA repair and enhance sensitivity to carboplatin and olaparib in HR proficient ovarian cancer cells. Oncotarget. 2014 May 15; 5(9):2678-87.
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MicroRNAs down-regulate homologous recombination in the G1 phase of cycling cells to maintain genomic stability. Elife. 2014 Apr 30; 3:e02445.
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Distinct phosphatases antagonize the p53 response in different phases of the cell cycle. Proc Natl Acad Sci U S A. 2014 May 20; 111(20):7313-8.
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Dephosphorylation enables the recruitment of 53BP1 to double-strand DNA breaks. Mol Cell. 2014 May 08; 54(3):512-25.
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EGFR-mediated chromatin condensation protects KRAS-mutant cancer cells against ionizing radiation. Cancer Res. 2014 May 15; 74(10):2825-34.
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Association of microRNAs and pathologic response to preoperative chemotherapy in triple negative breast cancer: preliminary report. Mol Biol Rep. 2014 May; 41(5):2851-7.
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A p21-ZEB1 complex inhibits epithelial-mesenchymal transition through the microRNA 183-96-182 cluster. Mol Cell Biol. 2014 Feb; 34(3):533-50.
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Stabilization of mutant BRCA1 protein confers PARP inhibitor and platinum resistance. Proc Natl Acad Sci U S A. 2013 Oct 15; 110(42):17041-6.
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Charity begins at home: non-coding RNA functions in DNA repair. Nat Rev Mol Cell Biol. 2013 03; 14(3):181-9.
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Inhibition of non-homologous end joining repair impairs pancreatic cancer growth and enhances radiation response. PLoS One. 2012; 7(6):e39588.
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Phosphoproteomic analysis reveals that PP4 dephosphorylates KAP-1 impacting the DNA damage response. EMBO J. 2012 May 16; 31(10):2403-15.
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DNA breaks and chromosome pulverization from errors in mitosis. Nature. 2012 Jan 18; 482(7383):53-8.
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MYC is activated by USP2a-mediated modulation of microRNAs in prostate cancer. Cancer Discov. 2012 Mar; 2(3):236-47.
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What goes on must come off: phosphatases gate-crash the DNA damage response. Trends Biochem Sci. 2011 Nov; 36(11):569-77.
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Translational control of TOP2A influences doxorubicin efficacy. Mol Cell Biol. 2011 Sep; 31(18):3790-801.
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Personalized therapy for urothelial cancer: review of the clinical evidence. Clin Investig (Lond). 2011 Apr; 1(4):546-555.
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miR-182-mediated downregulation of BRCA1 impacts DNA repair and sensitivity to PARP inhibitors. Mol Cell. 2011 Jan 21; 41(2):210-20.
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A PP4 phosphatase complex dephosphorylates RPA2 to facilitate DNA repair via homologous recombination. Nat Struct Mol Biol. 2010 Mar; 17(3):365-72.
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Distinct passenger strand and mRNA cleavage activities of human Argonaute proteins. Nat Struct Mol Biol. 2009 Dec; 16(12):1259-66.
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miR-24 Inhibits cell proliferation by targeting E2F2, MYC, and other cell-cycle genes via binding to "seedless" 3'UTR microRNA recognition elements. Mol Cell. 2009 Sep 11; 35(5):610-25.
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The cytotoxic T lymphocyte protease granzyme A cleaves and inactivates poly(adenosine 5'-diphosphate-ribose) polymerase-1. Blood. 2009 Aug 06; 114(6):1205-16.
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Human RIF1 encodes an anti-apoptotic factor required for DNA repair. Carcinogenesis. 2009 Aug; 30(8):1314-9.
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miR-24-mediated downregulation of H2AX suppresses DNA repair in terminally differentiated blood cells. Nat Struct Mol Biol. 2009 May; 16(5):492-8.
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Protein phosphatase PP4 is overexpressed in human breast and lung tumors. Cell Res. 2008 Sep; 18(9):974-7.
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A PP4-phosphatase complex dephosphorylates gamma-H2AX generated during DNA replication. Mol Cell. 2008 Jul 11; 31(1):33-46.
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Death by a thousand cuts: granzyme pathways of programmed cell death. Annu Rev Immunol. 2008; 26:389-420.
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RNA interference and cancer: endogenous pathways and therapeutic approaches. Adv Exp Med Biol. 2008; 615:299-329.
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Granzymes and cell death. Methods Enzymol. 2008; 442:213-30.
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Repeat organization and epigenetic regulation of the DH-Cmu domain of the immunoglobulin heavy-chain gene locus. Mol Cell. 2007 Sep 07; 27(5):842-50.
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Mutations in the gene encoding the 3'-5' DNA exonuclease TREX1 are associated with systemic lupus erythematosus. Nat Genet. 2007 Sep; 39(9):1065-7.
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A mutation in TREX1 that impairs susceptibility to granzyme A-mediated cell death underlies familial chilblain lupus. J Mol Med (Berl). 2007 May; 85(5):531-7.
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The exonuclease TREX1 is in the SET complex and acts in concert with NM23-H1 to degrade DNA during granzyme A-mediated cell death. Mol Cell. 2006 Jul 07; 23(1):133-42.
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Granzyme A, which causes single-stranded DNA damage, targets the double-strand break repair protein Ku70. EMBO Rep. 2006 Apr; 7(4):431-7.
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gamma-H2AX dephosphorylation by protein phosphatase 2A facilitates DNA double-strand break repair. Mol Cell. 2005 Dec 09; 20(5):801-9.
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An siRNA-based microbicide protects mice from lethal herpes simplex virus 2 infection. Nature. 2006 Jan 05; 439(7072):89-94.
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A phosphatase complex that dephosphorylates gammaH2AX regulates DNA damage checkpoint recovery. Nature. 2006 Jan 26; 439(7075):497-501.
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Potential roles for short RNAs in lymphocytes. Immunol Cell Biol. 2005 Jun; 83(3):201-10.
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Antibody mediated in vivo delivery of small interfering RNAs via cell-surface receptors. Nat Biotechnol. 2005 Jun; 23(6):709-17.
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RNAi and RNA-based regulation of immune system function. Adv Immunol. 2005; 88:267-92.
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Mechanisms for feedback inhibition of the immunoglobulin heavy chain locus. Curr Opin Immunol. 2004 Apr; 16(2):235-40.
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