Donald W. Kufe, MD

Donald W. Kufe, MD

Researcher

Contact Information

Office Phone Number

(617) 632-3141

Fax

(617) 632-2934

Biography

Donald W. Kufe, MD

Dr. Kufe received his MD in 1970 from the University of Rochester School of Medicine. After a clinical fellowship in medical oncology at Dana-Farber Cancer Institute, he joined the staff in 1979. He has served as chief of the Division of Cancer Pharmacology, deputy director of the Dana-Farber Cancer Center, director of the Harvard Phase I Oncology Group and leader of the Experimental Therapeutics Program. He is an editor of the textbook "Cancer Medicine."

Researcher

Physician

Distinguished Physician, Dana-Farber Cancer Institute
Professor of Medicine, Harvard Medical School

Recent Awards

  • Richard P. and Claire W. Morse Scientific Award, DFCI 1997
  • Faculty Research Award, American Cancer Society 1982
  • Scholar Award, Burroughs-Wellcome 1986
  • Lung Cancer Research Foundation, Scientific Merit Award 2010

Research

    Identification and characterization of the oncogenic MUC1-C protein. The Kufe laboratory identified DF3/MUC1 in the 1980s as a glycoprotein that is aberrantly overexpressed in ~90% of human breast cancers. Cloning of the DF3/MUC1 gene further identified a unique physical structure comprised of 20 amino acid tandem repeats. Subsequent work showed that MUC1 is a complex consisting of an extracellular N-terminal subunit with glycosylated tandem repeats (MUC1-N; the mucin component) and a C-terminal transmembrane subunit (MUC1-C; the signaling component). In providing protection from the external environment, normal epithelial cells respond to stress with release of MUC1-N into the protective mucous barrier and MUC1-C functions in the transduction of signals to the interior of the cell to promote loss of polarity and induce wound healing and repair. Appropriation of this response by overexpression of MUC1-C, as found in carcinoma cells, was shown to be sufficient for inducing anchorage-independent growth and tumorigenicity, providing the first evidence that MUC1-C functions as an oncoprotein.

    MUC1-C activates cell membrane and nuclear signaling pathways. Subsequent work demonstrated that MUC1-C drives loss of polarity, forms complexes with RTKs, such as EGFR, HER2 and others at the cell membrane, and contributes to their activation. These findings were extended by the demonstration that MUC1-C transduces signals from the cell membrane to the nucleus. As one example, MUC1-C was found to directly activate the proinflammatory IKK→NF-κB→p65 pathway, form complexes with p65 on promoters of target genes and contribute to their regulation. Other work showed that MUC1-C promotes the inflammatory response through activation of nuclear STAT1/3 signaling pathways, supporting the notion that MUC1-C contributes to the association between inflammation and cancer.

    MUC1-C induces EMT, self-renewal and epigenetic reprogramming. The Kufe laboratory first demonstrated that MUC1-C functions in the regulation of genes that drive EMT and self-renewal of cancer stem-like cells. Further work linked MUC1-C to epigenetic reprogramming by showing that MUC1-C regulates DNA methylation by activating the DNMT1 and DNMT3b genes. Advances also included unrecognized roles for MUC1-C in activating the PRC1/BMI1 and PRC2/EZH2 complexes in driving the repression of tumor suppressor genes, such as CHD1, CDKN2A, PTEN, BRCA1 and RASSF1A. Other studies showed that MUC1-C activates the highly conserved NuRD complex, which regulates chromatin assembly and reorganization and is of importance for EMT and invasion. These findings linked MUC1-C to integrating DNA methylation, histone regulation and chromatin remodeling in cancer cells.

    MUC1-C promotes genotoxic and targeted drug resistance. The early finding that MUC1-C confers resistance to genotoxic anti-cancer agents was attributed in part to suppression of the DNA damage-induced apoptotic response. Other work in this area extended involvement of MUC1-C in the repair of DNA damage and, more recently, the integration of chromatin remodeling in that response. Other studies showed that MUC1-C confers resistance to targeted agents, such as trastuzumab, tamoxifen, afatinib and others, and that targeting MUC1-C is synergistic with these agents in resistant cells.

    MUC1-C inhibits immune recognition and destruction. The Kufe laboratory first demonstrated that MUC1-C activates the PD-L1 gene and represses expression of immune effectors in cancer cells. In concert with these functions, targeting MUC1-C with a novel inhibitor downregulates PD-L1 in mouse tumor models and activates CD8+ T-cells in the immune microenvironment. In addition, MUC1 expression in human cancers correlates negatively with that of the CD8 and IFNγ genes and is associated with poor clinical outcomes. These findings provided the first evidence that MUC1-C plays a role in immune evasion.

    MUC1-C drives dedifferentiation and pluripotency cancer cells. Understanding how MUC1-C drives cancer cell plasticity and the multiple above hallmarks of the cancer cell is of critical importance. The Kufe laboratory has found that MUC1-C induces dedifferentiation and pluripotency of breast and prostate cancer cells. In this way, MUC1-C drives stemness in association with induction of Yamanaka pluripotency factors, which have been shown to confer lineage plasticity and dedifferentiation of fibroblasts. These findings have uncovered new lines of ongoing investigation to more precisely define how MUC1-C integrates dedifferentiation, stemness and pluripotency in cancer.

    Targeting MUC1-C with agents under development. There are presently no clinically available therapeutic agents against the MUC1-C subunit. To address this unmet need, the Kufe laboratory has developed potential therapeutics that target the MUC1-C extracellular and cytoplasmic domains. The generation of monoclonal antibodies (mAbs) against the MUC1-C extracellular domain provided the basis for development of CAR T-cells, BiTEs and antibody-drug conjugates. A cell-penetrating peptide directed against the MUC1-C cytoplasmic domain CQC motif, which is necessary for MUC1-C homodimerization and oncogenic function, is also under development with NCI Moonshot funding based on its activity in suppressing MUC1-C-induced drug resistance and immune evasion.

    Please view a timeline of Kufe lab discoveries on our lab website for more information about our work.

    Publications

      • The Cancer Moonshot Immuno-Oncology Translational Network (IOTN) at age 5: Accelerating Cancer Immunotherapies. J Natl Cancer Inst. 2023 Aug 12. View in: Pubmed

      • Single-cell analysis of localized prostate cancer patients links high Gleason score with an immunosuppressive profile. Prostate. 2023 06; 83(9):840-849. View in: Pubmed

      • MUC1-C is necessary for SHP2 activation and BRAF inhibitor resistance in BRAF(V600E) mutant colorectal cancer. Cancer Lett. 2023 04 10; 559:216116. View in: Pubmed

      • MUC1-C Dictates PBRM1-Mediated Chronic Induction of Interferon Signaling, DNA Damage Resistance, and Immunosuppression in Triple-Negative Breast Cancer. Mol Cancer Res. 2023 03 01; 21(3):274-289. View in: Pubmed

      • Dependence on MUC1-C in Progression of Neuroendocrine Prostate Cancer. Int J Mol Sci. 2023 Feb 13; 24(4). View in: Pubmed

      • MUC1-C is a master regulator of MICA/B NKG2D ligand and exosome secretion in human cancer cells. J Immunother Cancer. 2023 02; 11(2). View in: Pubmed

      • Emergence of MUC1 in Mammals for Adaptation of Barrier Epithelia. Cancers (Basel). 2022 Sep 30; 14(19). View in: Pubmed

      • Dependence on the MUC1-C Oncoprotein in Classic, Variant, and Non-neuroendocrine Small Cell Lung Cancer. Mol Cancer Res. 2022 09 02; 20(9):1379-1390. View in: Pubmed

      • Addiction of Cancer Stem Cells to MUC1-C in Triple-Negative Breast Cancer Progression. Int J Mol Sci. 2022 Jul 26; 23(15). View in: Pubmed

      • Personalized tumor vaccine for pancreatic cancer. Cancer Immunol Immunother. 2022 Jul 14. View in: Pubmed

      • Addiction of Merkel cell carcinoma to MUC1-C identifies a potential new target for treatment. Oncogene. 2022 07; 41(27):3511-3523. View in: Pubmed

      • Targeting MUC1-C Suppresses Chronic Activation of Cytosolic Nucleotide Receptors and STING in Triple-Negative Breast Cancer. Cancers (Basel). 2022 May 24; 14(11). View in: Pubmed

      • MUC1-C Dictates JUN and BAF-Mediated Chromatin Remodeling at Enhancer Signatures in Cancer Stem Cells. Mol Cancer Res. 2022 04 01; 20(4):556-567. View in: Pubmed

      • Chronic activation of MUC1-C in wound repair promotes progression to cancer stem cells. J Cancer Metastasis Treat. 2022; 8. View in: Pubmed

      • MUC1-C dictates neuroendocrine lineage specification in pancreatic ductal adenocarcinomas. Carcinogenesis. 2022 02 11; 43(1):67-76. View in: Pubmed

      • MUC1-C integrates type II interferon and chromatin remodeling pathways in immunosuppression of prostate cancer. Oncoimmunology. 2022; 11(1):2029298. View in: Pubmed

      • Novel insights into the roles and therapeutic implications of MUC1 oncoprotein via regulating proteins and non-coding RNAs in cancer. Theranostics. 2022; 12(3):999-1011. View in: Pubmed

      • The Cancer Epitope Database and Analysis Resource: A Blueprint for the Establishment of a New Bioinformatics Resource for Use by the Cancer Immunology Community. Front Immunol. 2021; 12:735609. View in: Pubmed

      • MUC1-C activates the PBAF chromatin remodeling complex in integrating redox balance with progression of human prostate cancer stem cells. Oncogene. 2021 07; 40(30):4930-4940. View in: Pubmed

      • Correction: Targeting the eIF4A RNA helicase blocks translation of the MUC1-C oncoprotein. Oncogene. 2021 May; 40(18):3347. View in: Pubmed

      • Leukemia vaccine overcomes limitations of checkpoint blockade by evoking clonal T cell responses in a murine acute myeloid leukemia model. Haematologica. 2021 05 01; 106(5):1330-1342. View in: Pubmed

      • MUC1-C integrates activation of the IFN-? pathway with suppression of the tumor immune microenvironment in triple-negative breast cancer. J Immunother Cancer. 2021 01; 9(1). View in: Pubmed

      • MUC1-C Activates the BAF (mSWI/SNF) Complex in Prostate Cancer Stem Cells. Cancer Res. 2021 02 15; 81(4):1111-1122. View in: Pubmed

      • MUC1-C in chronic inflammation and carcinogenesis; emergence as a target for cancer treatment. Carcinogenesis. 2020 09 24; 41(9):1173-1183. View in: Pubmed

      • Role of the MUC1-C oncoprotein in the acquisition of cisplatin resistance by urothelial carcinoma. Cancer Sci. 2020 Oct; 111(10):3639-3652. View in: Pubmed

      • Anti-MUC1-C Antibody-Conjugated Nanoparticles Potentiate the Efficacy of Fractionated Radiation Therapy. Int J Radiat Oncol Biol Phys. 2020 12 01; 108(5):1380-1389. View in: Pubmed

      • MUC1-C drives stemness in progression of colitis to colorectal cancer. JCI Insight. 2020 06 18; 5(12). View in: Pubmed

      • Cancer Moonshot Immuno-Oncology Translational Network (IOTN): accelerating the clinical translation of basic discoveries for improving immunotherapy and immunoprevention of cancer. J Immunother Cancer. 2020 06; 8(1). View in: Pubmed

      • Author Correction: MUC1-C regulates lineage plasticity driving progression to neuroendocrine prostate cancer. Nat Commun. 2020 Feb 24; 11(1):1095. View in: Pubmed

      • MUC1-C regulates lineage plasticity driving progression to neuroendocrine prostate cancer. Nat Commun. 2020 01 17; 11(1):338. View in: Pubmed

      • Correction: MUC1-C represses the RASSF1A tumor suppressor in human carcinoma cells. Oncogene. 2019 Nov; 38(47):7278. View in: Pubmed

      • MUC1-C Activates the NuRD Complex to Drive Dedifferentiation of Triple-Negative Breast Cancer Cells. Cancer Res. 2019 11 15; 79(22):5711-5722. View in: Pubmed

      • MUC1-C represses the RASSF1A tumor suppressor in human carcinoma cells. Oncogene. 2019 11; 38(47):7266-7277. View in: Pubmed

      • Targeting MUC1-C Inhibits TWIST1 Signaling in Triple-Negative Breast Cancer. Mol Cancer Ther. 2019 10; 18(10):1744-1754. View in: Pubmed

      • Hypomethylating agent alters the immune microenvironment in acute myeloid leukaemia (AML) and enhances the immunogenicity of a dendritic cell/AML vaccine. Br J Haematol. 2019 05; 185(4):679-690. View in: Pubmed

      • MUC1-C Integrates Chromatin Remodeling and PARP1 Activity in the DNA Damage Response of Triple-Negative Breast Cancer Cells. Cancer Res. 2019 04 15; 79(8):2031-2041. View in: Pubmed

      • Corrigendum to 'Concomitant delivery of paclitaxel and NuBCP-9 peptide for synergistic enhancement of cancer therapy' NANO 14 (2018) 1301-1313. Nanomedicine. 2018 10; 14(7):2129. View in: Pubmed

      • Targeting the human MUC1-C oncoprotein with an antibody-drug conjugate. JCI Insight. 2018 06 21; 3(12). View in: Pubmed

      • MUC1-C drives myeloid leukaemogenesis and resistance to treatment by a survivin-mediated mechanism. J Cell Mol Med. 2018 Aug; 22(8):3887-3898. View in: Pubmed

      • Targeting MUC1-C suppresses BCL2A1 in triple-negative breast cancer. Signal Transduct Target Ther. 2018; 3:13. View in: Pubmed

      • Concomitant Delivery of Paclitaxel and NuBCP-9 peptide for synergistic enhancement of cancer therapy. Nanomedicine. 2018 06; 14(4):1301-1313. View in: Pubmed

      • MUC1-C activates polycomb repressive complexes and downregulates tumor suppressor genes in human cancer cells. Oncogene. 2018 04; 37(16):2079-2088. View in: Pubmed

      • MUC1-C Induces PD-L1 and Immune Evasion in Triple-Negative Breast Cancer. Cancer Res. 2018 01 01; 78(1):205-215. View in: Pubmed

      • CBP501 induces immunogenic tumor cell death and CD8 T cell infiltration into tumors in combination with platinum, and increases the efficacy of immune checkpoint inhibitors against tumors in mice. Oncotarget. 2017 Oct 03; 8(45):78277-78288. View in: Pubmed

      • Targeting MUC1-C suppresses polycomb repressive complex 1 in multiple myeloma. Oncotarget. 2017 Sep 19; 8(41):69237-69249. View in: Pubmed

      • MUC1-C activates EZH2 expression and function in human cancer cells. Sci Rep. 2017 08 07; 7(1):7481. View in: Pubmed

      • Decitabine Priming Enhances Mucin 1 Inhibition Mediated Disruption of Redox Homeostasis in Cutaneous T-Cell Lymphoma. Mol Cancer Ther. 2017 10; 16(10):2304-2314. View in: Pubmed

      • CBP501 suppresses macrophage induced cancer stem cell like features and metastases. Oncotarget. 2017 Sep 08; 8(38):64015-64031. View in: Pubmed

      • MUC1-C promotes the suppressive immune microenvironment in non-small cell lung cancer. Oncoimmunology. 2017; 6(9):e1338998. View in: Pubmed

      • MUC1-C is a target in lenalidomide resistant multiple myeloma. Br J Haematol. 2017 09; 178(6):914-926. View in: Pubmed

      • CBP501 inhibits EGF-dependent cell migration, invasion and epithelial-to-mesenchymal transition of non-small cell lung cancer cells by blocking KRas to calmodulin binding. Oncotarget. 2017 Sep 26; 8(43):74006-74018. View in: Pubmed

      • CBP501 inhibits EGF-dependent cell migration, invasion and epithelial-to-mesenchymal transition of non-small cell lung cancer cells by blocking KRas to Calmodulin binding. Oncotarget. 2017 Jun 22. View in: Pubmed

      • MUC1 inhibition leads to decrease in PD-L1 levels via upregulation of miRNAs. Leukemia. 2017 12; 31(12):2780-2790. View in: Pubmed

      • Systemic delivery of the tumor necrosis factor gene to tumors by a novel dual DNA-nanocomplex in a nanoparticle system. Nanomedicine. 2017 07; 13(5):1833-1839. View in: Pubmed

      • MUC1-C Oncoprotein Integrates a Program of EMT, Epigenetic Reprogramming and Immune Evasion in Human Carcinomas. Biochim Biophys Acta Rev Cancer. 2017 Aug; 1868(1):117-122. View in: Pubmed

      • MUC1-C integrates PD-L1 induction with repression of immune effectors in non-small-cell lung cancer. Oncogene. 2017 07 13; 36(28):4037-4046. View in: Pubmed

      • Targeting MUC1-C inhibits the AKT-S6K1-elF4A pathway regulating TIGAR translation in colorectal cancer. Mol Cancer. 2017 02 02; 16(1):33. View in: Pubmed

      • MUC1-mediated induction of myeloid-derived suppressor cells in patients with acute myeloid leukemia. Blood. 2017 Mar 30; 129(13):1791-1801. View in: Pubmed

      • Bone marrow stroma protects myeloma cells from cytotoxic damage via induction of the oncoprotein MUC1. Br J Haematol. 2017 03; 176(6):929-938. View in: Pubmed

      • MUC1-C drives DNA methylation in cancer. Aging (Albany NY). 2016 12 28; 8(12):3155-3156. View in: Pubmed

      • Individualized vaccination of AML patients in remission is associated with induction of antileukemia immunity and prolonged remissions. Sci Transl Med. 2016 12 07; 8(368):368ra171. View in: Pubmed

      • Ad.Egr-TNF and Local Ionizing Radiation Suppress Metastases by Interferon-ß-Dependent Activation of Antigen-specific CD8+ T Cells. Mol Ther. 2010 May; 18(5):912-920. View in: Pubmed

      • MUC1-C activates BMI1 in human cancer cells. Oncogene. 2017 05 18; 36(20):2791-2801. View in: Pubmed

      • MUC1-C Represses the Crumbs Complex Polarity Factor CRB3 and Downregulates the Hippo Pathway. Mol Cancer Res. 2016 12; 14(12):1266-1276. View in: Pubmed

      • Multiparametric profiling of non-small-cell lung cancers reveals distinct immunophenotypes. JCI Insight. 2016 09 08; 1(14):e89014. View in: Pubmed

      • MUC1-C induces DNA methyltransferase 1 and represses tumor suppressor genes in acute myeloid leukemia. Oncotarget. 2016 Jun 28; 7(26):38974-38987. View in: Pubmed

      • MUC1 in hematological malignancies. Leuk Lymphoma. 2016 11; 57(11):2489-98. View in: Pubmed

      • MUC1-C Stabilizes MCL-1 in the Oxidative Stress Response of Triple-Negative Breast Cancer Cells to BCL-2 Inhibitors. Sci Rep. 2016 05 24; 6:26643. View in: Pubmed

      • DNA methylation by DNMT1 and DNMT3b methyltransferases is driven by the MUC1-C oncoprotein in human carcinoma cells. Oncogene. 2016 12 15; 35(50):6439-6445. View in: Pubmed

      • Functional interactions of the cystine/glutamate antiporter, CD44v and MUC1-C oncoprotein in triple-negative breast cancer cells. Oncotarget. 2016 Mar 15; 7(11):11756-69. View in: Pubmed

      • MUC1-C drives MYC in multiple myeloma. Blood. 2016 05 26; 127(21):2587-97. View in: Pubmed

      • Inhibition of MUC1-C Suppresses MYC Expression and Attenuates Malignant Growth in KRAS Mutant Lung Adenocarcinomas. Cancer Res. 2016 Mar 15; 76(6):1538-48. View in: Pubmed

      • Characterization of the MUC1-C Cytoplasmic Domain as a Cancer Target. PLoS One. 2015; 10(8):e0135156. View in: Pubmed

      • Mucin 1 is a potential therapeutic target in cutaneous T-cell lymphoma. Blood. 2015 Jul 16; 126(3):354-62. View in: Pubmed

      • Intracellular Targeting of the Oncogenic MUC1-C Protein with a Novel GO-203 Nanoparticle Formulation. Clin Cancer Res. 2015 May 15; 21(10):2338-47. View in: Pubmed

      • MUC1-C activates the TAK1 inflammatory pathway in colon cancer. Oncogene. 2015 Oct 01; 34(40):5187-97. View in: Pubmed

      • MUC1-C Induces the LIN28B?LET-7?HMGA2 Axis to Regulate Self-Renewal in NSCLC. Mol Cancer Res. 2015 Mar; 13(3):449-60. View in: Pubmed

      • MUC1-C confers EMT and KRAS independence in mutant KRAS lung cancer cells. Oncotarget. 2014 Oct 15; 5(19):8893-905. View in: Pubmed

      • CBS9106-induced CRM1 degradation is mediated by cullin ring ligase activity and the neddylation pathway. Mol Cancer Ther. 2014 Dec; 13(12):3013-23. View in: Pubmed

      • Targeting the oncogenic MUC1-C protein inhibits mutant EGFR-mediated signaling and survival in non-small cell lung cancer cells. Clin Cancer Res. 2014 Nov 01; 20(21):5423-34. View in: Pubmed

      • Activation of Nrf2 pathways correlates with resistance of NSCLC cell lines to CBP501 in vitro. Mol Cancer Ther. 2014 Sep; 13(9):2215-25. View in: Pubmed

      • Targeting the MUC1-C oncoprotein inhibits self-renewal capacity of breast cancer cells. Oncotarget. 2014 May 15; 5(9):2622-34. View in: Pubmed

      • Novel polymeric nanoparticles for intracellular delivery of peptide Cargos: antitumor efficacy of the BCL-2 conversion peptide NuBCP-9. Cancer Res. 2014 Jun 15; 74(12):3271-81. View in: Pubmed

      • Targeting MUC1-C is synergistic with bortezomib in downregulating TIGAR and inducing ROS-mediated myeloma cell death. Blood. 2014 May 08; 123(19):2997-3006. View in: Pubmed

      • MUC1-C oncoprotein promotes FLT3 receptor activation in acute myeloid leukemia cells. Blood. 2014 Jan 30; 123(5):734-42. View in: Pubmed

      • MUC1-C oncoprotein activates ERK?C/EBPß signaling and induction of aldehyde dehydrogenase 1A1 in breast cancer cells. J Biol Chem. 2013 Oct 25; 288(43):30892-903. View in: Pubmed

      • Targeting the MUC1-C oncoprotein downregulates HER2 activation and abrogates trastuzumab resistance in breast cancer cells. Oncogene. 2014 Jun 26; 33(26):3422-31. View in: Pubmed

      • MUC1 is a potential target for the treatment of acute myeloid leukemia stem cells. Cancer Res. 2013 Sep 01; 73(17):5569-79. View in: Pubmed

      • Vaccination with dendritic cell/tumor fusions following autologous stem cell transplant induces immunologic and clinical responses in multiple myeloma patients. Clin Cancer Res. 2013 Jul 01; 19(13):3640-8. View in: Pubmed

      • MUC1-C oncoprotein activates the ZEB1/miR-200c regulatory loop and epithelial-mesenchymal transition. Oncogene. 2014 Mar 27; 33(13):1680-9. View in: Pubmed

      • Oncogenic MUC1-C promotes tamoxifen resistance in human breast cancer. Mol Cancer Res. 2013 Jul; 11(7):714-23. View in: Pubmed

      • Inhibition of the MUC1-C oncoprotein is synergistic with cytotoxic agents in the treatment of breast cancer cells. Cancer Biol Ther. 2013 Feb; 14(2):127-34. View in: Pubmed

      • Induction of antitumor immunity ex vivo using dendritic cells transduced with fowl pox vector expressing MUC1, CEA, and a triad of costimulatory molecules (rF-PANVAC). J Immunother. 2012 Sep; 35(7):555-69. View in: Pubmed

      • Cooperative interaction between the MUC1-C oncoprotein and the Rab31 GTPase in estrogen receptor-positive breast cancer cells. PLoS One. 2012; 7(7):e39432. View in: Pubmed

      • Lenalidomide enhances anti-myeloma cellular immunity. Cancer Immunol Immunother. 2013 Jan; 62(1):39-49. View in: Pubmed

      • Targeting the eIF4A RNA helicase blocks translation of the MUC1-C oncoprotein. Oncogene. 2013 Apr 25; 32(17):2179-88. View in: Pubmed

      • Dendritic/tumor fusion cells as cancer vaccines. Semin Oncol. 2012 Jun; 39(3):287-95. View in: Pubmed

      • A phase I first-in-human trial of bardoxolone methyl in patients with advanced solid tumors and lymphomas. Clin Cancer Res. 2012 Jun 15; 18(12):3396-406. View in: Pubmed

      • MUC1-C oncoprotein as a target in breast cancer: activation of signaling pathways and therapeutic approaches. Oncogene. 2013 Feb 28; 32(9):1073-81. View in: Pubmed

      • The MUC1-C oncoprotein binds to the BH3 domain of the pro-apoptotic BAX protein and blocks BAX function. J Biol Chem. 2012 Jun 15; 287(25):20866-75. View in: Pubmed

      • MUC1-C oncoprotein confers androgen-independent growth of human prostate cancer cells. Prostate. 2012 Nov; 72(15):1659-68. View in: Pubmed

      • MUC1-C oncoprotein induces TCF7L2 transcription factor activation and promotes cyclin D1 expression in human breast cancer cells. J Biol Chem. 2012 Mar 23; 287(13):10703-10713. View in: Pubmed

      • Targeting cysteine-mediated dimerization of the MUC1-C oncoprotein in human cancer cells. Int J Oncol. 2012 May; 40(5):1643-9. View in: Pubmed

      • A monoclonal antibody against the oncogenic mucin 1 cytoplasmic domain. Hybridoma (Larchmt). 2011 Dec; 30(6):531-5. View in: Pubmed

      • MUC1-C oncoprotein regulates glycolysis and pyruvate kinase M2 activity in cancer cells. PLoS One. 2011; 6(11):e28234. View in: Pubmed

      • Inhibition of the MUC1-C oncoprotein induces multiple myeloma cell death by down-regulating TIGAR expression and depleting NADPH. Blood. 2012 Jan 19; 119(3):810-6. View in: Pubmed

      • CBS9106 is a novel reversible oral CRM1 inhibitor with CRM1 degrading activity. Blood. 2011 Oct 06; 118(14):3922-31. View in: Pubmed

      • CBP501-calmodulin binding contributes to sensitizing tumor cells to cisplatin and bleomycin. Mol Cancer Ther. 2011 Oct; 10(10):1929-38. View in: Pubmed

      • PD-1 blockade by CT-011, anti-PD-1 antibody, enhances ex vivo T-cell responses to autologous dendritic cell/myeloma fusion vaccine. J Immunother. 2011 Jun; 34(5):409-18. View in: Pubmed

      • MUC1-C oncoprotein suppresses reactive oxygen species-induced terminal differentiation of acute myelogenous leukemia cells. Blood. 2011 May 05; 117(18):4863-70. View in: Pubmed

      • Dependence on the MUC1-C oncoprotein in non-small cell lung cancer cells. Mol Cancer Ther. 2011 May; 10(5):806-16. View in: Pubmed

      • Mucin 1 C-terminal subunit oncoprotein is a target for small-molecule inhibitors. Mol Pharmacol. 2011 May; 79(5):886-93. View in: Pubmed

      • MUC1-C oncoprotein promotes STAT3 activation in an autoinductive regulatory loop. Sci Signal. 2011 Feb 15; 4(160):ra9. View in: Pubmed

      • Androgen receptor regulates expression of the MUC1-C oncoprotein in human prostate cancer cells. Prostate. 2011 Sep; 71(12):1299-308. View in: Pubmed

      • Phase I studies of CBP501, a G2 checkpoint abrogator, as monotherapy and in combination with cisplatin in patients with advanced solid tumors. Clin Cancer Res. 2011 May 15; 17(10):3431-42. View in: Pubmed

      • MUC1-C Oncoprotein Blocks Terminal Differentiation of Chronic Myelogenous Leukemia Cells by a ROS-Mediated Mechanism. Genes Cancer. 2011 Jan; 2(1):56-64. View in: Pubmed

      • Vaccination with dendritic cell/tumor fusion cells results in cellular and humoral antitumor immune responses in patients with multiple myeloma. Blood. 2011 Jan 13; 117(2):393-402. View in: Pubmed

      • Terminal differentiation of chronic myelogenous leukemia cells is induced by targeting of the MUC1-C oncoprotein. Cancer Biol Ther. 2010 Sep 01; 10(5):483-91. View in: Pubmed

      • Oncogenic function of the MUC1 receptor subunit in gene regulation. Oncogene. 2010 Oct 21; 29(42):5663-6. View in: Pubmed

      • miR-1226 targets expression of the mucin 1 oncoprotein and induces cell death. Int J Oncol. 2010 Jul; 37(1):61-9. View in: Pubmed

      • Combining the FLT3 inhibitor PKC412 and the triterpenoid CDDO-Me synergistically induces apoptosis in acute myeloid leukemia with the internal tandem duplication mutation. Mol Cancer Res. 2010 Jul; 8(7):986-93. View in: Pubmed

      • MUC1-associated proliferation signature predicts outcomes in lung adenocarcinoma patients. BMC Med Genomics. 2010 May 06; 3:16. View in: Pubmed

      • Survival of human multiple myeloma cells is dependent on MUC1 C-terminal transmembrane subunit oncoprotein function. Mol Pharmacol. 2010 Aug; 78(2):166-74. View in: Pubmed

      • Ad.Egr-TNF and local ionizing radiation suppress metastases by interferon-beta-dependent activation of antigen-specific CD8+ T cells. Mol Ther. 2010 May; 18(5):912-20. View in: Pubmed

      • MUC1-C Oncoprotein Interacts Directly with ATM and Promotes the DNA Damage Response to Ionizing Radiation. Genes Cancer. 2010 Mar; 1(3):239-250. View in: Pubmed

      • Generation of tumor-specific T lymphocytes using dendritic cell/tumor fusions and anti-CD3/CD28. J Immunother. 2010 Feb-Mar; 33(2):155-66. View in: Pubmed

      • Immunomodulatory effects of vitamin D: implications for GVHD. Bone Marrow Transplant. 2010 Sep; 45(9):1463-8. View in: Pubmed

      • MUCIN 1 ONCOPROTEIN EXPRESSION IS SUPPRESSED BY THE miR-125b ONCOMIR. Genes Cancer. 2010 Jan 01; 1(1):62-68. View in: Pubmed

      • Mucins in cancer: function, prognosis and therapy. Nat Rev Cancer. 2009 Dec; 9(12):874-85. View in: Pubmed

      • Cooperativity of the MUC1 oncoprotein and STAT1 pathway in poor prognosis human breast cancer. Oncogene. 2010 Feb 11; 29(6):920-9. View in: Pubmed

      • MUC1 oncoprotein is a druggable target in human prostate cancer cells. Mol Cancer Ther. 2009 Nov; 8(11):3056-65. View in: Pubmed

      • MUC1-C oncoprotein functions as a direct activator of the nuclear factor-kappaB p65 transcription factor. Cancer Res. 2009 Sep 01; 69(17):7013-21. View in: Pubmed

      • Functional targeting of the MUC1 oncogene in human cancers. Cancer Biol Ther. 2009 Jul; 8(13):1197-203. View in: Pubmed

      • Direct targeting of the mucin 1 oncoprotein blocks survival and tumorigenicity of human breast carcinoma cells. Cancer Res. 2009 Jun 15; 69(12):5133-41. View in: Pubmed

      • MUC1 oncoprotein promotes autophagy in a survival response to glucose deprivation. Int J Oncol. 2009 Jun; 34(6):1691-9. View in: Pubmed

      • Translation of the radio- and chemo-inducible TNFerade vector to the treatment of human cancers. Cancer Gene Ther. 2009 Aug; 16(8):609-19. View in: Pubmed

      • MUC1-induced transcriptional programs associated with tumorigenesis predict outcome in breast and lung cancer. Cancer Res. 2009 Apr 01; 69(7):2833-7. View in: Pubmed

      • MUC1-induced alterations in a lipid metabolic gene network predict response of human breast cancers to tamoxifen treatment. Proc Natl Acad Sci U S A. 2009 Apr 07; 106(14):5837-41. View in: Pubmed

      • MUC1 oncoprotein suppresses activation of the ARF-MDM2-p53 pathway. Cancer Biol Ther. 2008 Dec; 7(12):1959-67. View in: Pubmed

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      Dana-Farber Cancer Institute

      450 Brookline Avenue Dana 830B Boston, MA 02215
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      Dana-Farber Cancer Institute

      Location Avtar

      Dana-Farber Cancer Institute

      450 Brookline Avenue Dana 830B Boston, MA 02215
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      42.3374, -71.1082