Ellis L. Reinherz, MD

Researcher

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Researcher

Professor of Medicine, Harvard Medical School

Contact Information

Office Phone Number617-632-3412
Fax617-632-3351

Bio

Dr. Ellis Reinherz received his MD from Harvard Medical School in 1975. After an internship and residency at Massachusetts General Hospital from 1975-1977 and a period as a hematology fellow at Brigham and Women's Hospital from 1977-1978, he joined DFCI. His work has revealed key functional and structural information about T cell receptors (TCRs), the CD3 signaling subunits, and how, with other molecules, TCRs bind to peptide-loaded MHC (pMHC). His findings have implications for rational vaccine design.

Research

View Dr. Reinherz's Research

Molecular Mechanisms of T Cell Recognition
The Ellis laboratory's focus is on the adaptive immune response with respect to those multiple subunit plasma membrane receptors, namely TCRs and preTCRs, that recognize peptides bound to pMHC. abTCRs specifically bind to "foreign" peptides, cradled in the groove of MHC molecules and displayed on infected or otherwise perturbed cells including tumor cells through a process that discriminates among potential ligands with exquisite specificity. The paradox that a mere handful of foreign peptides among 100,000 self-peptides is sufficient for cytotoxic T lymphocytes (CTLs) to accurately mount a deadly response or helper T cell to become activated despite apparent weak TCR-pMHC binding at thermal equilibrium was unexplained. Recently, however, it has become clear that TCRs and preTCRs, unlike antibodies, work far from thermal equilibrium, harnessing energy both externally from cell motion during migration and internally from underlying cytoskeletal elements and associated motor proteins. Force-dependent structural transitions and allostery regulate peptide discrimination and pMHC-receptor bond lifetime, allowing for essentially digital mechanosensing to initiate downstream signaling events and immunological synapse formation. Optical tweezers or related technologies to mimic in vivo bioforces can discriminate between T cells whose TCRs manifest outstanding recognition with those which are of poor acuity (several vs. hundreds of pMHC ligands per cell surface, respectively). By developing mechanobiology-dependent T cell readouts in conjunction with ultrasensitive physical detection (i.e. mass spectrometry) rivaling that of high avidity T cells, rational CTL-based vaccine design can follow. The implications for immunotherapeutic vaccines targeting neoantigens, as one example, are significant. Bioforce-dependent measurements can eliminate the micromolar peptide concentrations used to assess T cell recognition via current functional reverse immunology (RI). The latter encourages TCR crossreactivities at high antigen dose and zero force, resulting in false positive detections. In addition, RI is unable to detect stealth epitopes that fail to naturally stimulate T cells due to issues of immunodominance or crosspresentation failure. Notwithstanding, such epitopes may be ideal as targets for CTL vaccine programming.

View Dr. Reinherz's Publications

Pre-T cell receptor self-MHC sampling restricts thymocyte dedifferentiation. Nature. 2023 01; 613(7944):565-574.
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Dynamic HIV-1 spike motion creates vulnerability for its membrane-bound tripod to antibody attack. Nat Commun. 2022 10 27; 13(1):6393.
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TCR-mimic bispecific antibodies to target the HIV-1 reservoir. Proc Natl Acad Sci U S A. 2022 04 12; 119(15):e2123406119.
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Measuring aß T-Cell Receptor-Mediated Mechanosensing Using Optical Tweezers Combined with Fluorescence Imaging. Methods Mol Biol. 2022; 2478:727-753.
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Characterization of Conserved and Promiscuous Human Rhinovirus CD4 T Cell Epitopes. Cells. 2021 09 02; 10(9).
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Single Molecule Force Spectroscopy Reveals Distinctions in Key Biophysical Parameters of aß T-Cell Receptors Compared with Chimeric Antigen Receptors Directed at the Same Ligand. J Phys Chem Lett. 2021 Aug 12; 12(31):7566-7573.
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Molecular design of the ?dT cell receptor ectodomain encodes biologically fit ligand recognition in the absence of mechanosensing. Proc Natl Acad Sci U S A. 2021 06 29; 118(26).
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Intrinsic Immunogenicity of Small Cell Lung Carcinoma Revealed by Its Cellular Plasticity. Cancer Discov. 2021 08; 11(8):1952-1969.
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A general chemical crosslinking strategy for structural analyses of weakly interacting proteins applied to preTCR-pMHC complexes. J Biol Chem. 2021 Jan-Jun; 296:100255.
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A general chemical crosslinking strategy for structural analyses of weakly interacting proteins applied to preTCR-pMHC complexes. J Biol Chem. 2021 Jan 04.
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Pre-T cell receptors topologically sample self-ligands during thymocyte ß-selection. Science. 2021 01 08; 371(6525):181-185.
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The aßTCR mechanosensor exploits dynamic ectodomain allostery to optimize its ligand recognition site. Proc Natl Acad Sci U S A. 2020 09 01; 117(35):21336-21345.
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Cancer Neoepitopes for Immunotherapy: Discordance Between Tumor-Infiltrating T Cell Reactivity and Tumor MHC Peptidome Display. Front Immunol. 2019; 10:2766.
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Topological analysis of the gp41 MPER on lipid bilayers relevant to the metastable HIV-1 envelope prefusion state. Proc Natl Acad Sci U S A. 2019 11 05; 116(45):22556-22566.
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The structure of a T-cell mechanosensor. Nature. 2019 09; 573(7775):502-504.
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Pillars Article: Restoration of T Cell Development in RAG-2-Deficient Mice by Functional TCR Transgenes. Science. 1993. 259: 822-825. J Immunol. 2019 03 01; 202(5):1317-1320.
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NMR: an essential structural tool for integrative studies of T cell development, pMHC ligand recognition and TCR mechanobiology. J Biomol NMR. 2019 Jul; 73(6-7):319-332.
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The T Cell Antigen Receptor a Transmembrane Domain Coordinates Triggering through Regulation of Bilayer Immersion and CD3 Subunit Associations. Immunity. 2018 11 20; 49(5):829-841.e6.
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Co-delivery of a CD4 T cell helper epitope via covalent liposome attachment with a surface-arrayed B cell target antigen fosters higher affinity antibody responses. Vaccine. 2018 10 01; 36(41):6191-6201.
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aß T Cell Receptor Mechanosensing Forces out Serial Engagement. Trends Immunol. 2018 08; 39(8):596-609.
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Regulation of thymocyte trafficking by Tagap, a GAP domain protein linked to human autoimmunity. Sci Signal. 2018 06 12; 11(534).
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Surface-Matrix Screening Identifies Semi-specific Interactions that Improve Potency of a Near Pan-reactive HIV-1-Neutralizing Antibody. Cell Rep. 2018 02 13; 22(7):1798-1809.
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NMR-directed design of pre-TCRß and pMHC molecules implies a distinct geometry for pre-TCR relative to aßTCR recognition of pMHC. J Biol Chem. 2018 01 19; 293(3):754-766.
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TCR-pMHC encounter differentially regulates transcriptomes of tissue-resident CD8 T cells. Eur J Immunol. 2018 01; 48(1):128-150.
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Mechanosensing drives acuity of aß T-cell recognition. Proc Natl Acad Sci U S A. 2017 09 26; 114(39):E8204-E8213.
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TANTIGEN: a comprehensive database of tumor T cell antigens. Cancer Immunol Immunother. 2017 Jun; 66(6):731-735.
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Germinal Center Hypoxia Potentiates Immunoglobulin Class Switch Recombination. J Immunol. 2016 11 15; 197(10):4014-4020.
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Pre-T Cell Receptors (Pre-TCRs) Leverage Vß Complementarity Determining Regions (CDRs) and Hydrophobic Patch in Mechanosensing Thymic Self-ligands. J Biol Chem. 2016 Dec 02; 291(49):25292-25305.
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Generation of Long-Lived Bone Marrow Plasma Cells Secreting Antibodies Specific for the HIV-1 gp41 Membrane-Proximal External Region in the Absence of Polyreactivity. J Virol. 2016 10 01; 90(19):8875-90.
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A computational method for identification of vaccine targets from protein regions of conserved human leukocyte antigen binding. BMC Med Genomics. 2015; 8 Suppl 4:S1.
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FluKB: A Knowledge-Based System for Influenza Vaccine Target Discovery and Analysis of the Immunological Properties of Influenza Viruses. J Immunol Res. 2015; 2015:380975.
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Structural Features of the aßTCR Mechanotransduction Apparatus That Promote pMHC Discrimination. Front Immunol. 2015; 6:441.
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Backbone resonance assignment of N15, N30 and D10 T cell receptor ß subunits. Biomol NMR Assign. 2016 Apr; 10(1):35-9.
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Pre-TCR ligand binding impacts thymocyte development before aßTCR expression. Proc Natl Acad Sci U S A. 2015 Jul 07; 112(27):8373-8.
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Reply to van de Sandt and Rimmelzwaan: Matching epitope display with functional avidity. Proc Natl Acad Sci U S A. 2015 May 12; 112(19):E2418.
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aß TCR-mediated recognition: relevance to tumor-antigen discovery and cancer immunotherapy. Cancer Immunol Res. 2015 Apr; 3(4):305-12.
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Codification of bidentate pMHC interaction with TCR and its co-receptor. Trends Immunol. 2015 May; 36(5):300-6.
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Physical detection of influenza A epitopes identifies a stealth subset on human lung epithelium evading natural CD8 immunity. Proc Natl Acad Sci U S A. 2015 Feb 17; 112(7):2151-6.
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Force-dependent transition in the T-cell receptor ß-subunit allosterically regulates peptide discrimination and pMHC bond lifetime. Proc Natl Acad Sci U S A. 2015 Feb 03; 112(5):1517-22.
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Liposomal vaccines incorporating molecular adjuvants and intrastructural T-cell help promote the immunogenicity of HIV membrane-proximal external region peptides. Vaccine. 2015 Feb 11; 33(7):861-8.
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Constitutively oxidized CXXC motifs within the CD3 heterodimeric ectodomains of the T cell receptor complex enforce the conformation of juxtaposed segments. J Biol Chem. 2015 Jan 2; 290(1):239.
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Human leukocyte antigen typing using a knowledge base coupled with a high-throughput oligonucleotide probe array analysis. Front Immunol. 2014; 5:597.
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Revisiting the Discovery of the aß TCR Complex and Its Co-Receptors. Front Immunol. 2014; 5:583.
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Forward Vaccinology: CTL Targeting Based upon Physical Detection of HLA-Bound Peptides. Front Immunol. 2014; 5:418.
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Constitutively oxidized CXXC motifs within the CD3 heterodimeric ectodomains of the T cell receptor complex enforce the conformation of juxtaposed segments. J Biol Chem. 2014 Jul 04; 289(27):18880-92.
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Quantitative phosphoproteomic analysis reveals system-wide signaling pathways downstream of SDF-1/CXCR4 in breast cancer stem cells. Proc Natl Acad Sci U S A. 2014 May 27; 111(21):E2182-90.
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HPVdb: a data mining system for knowledge discovery in human papillomavirus with applications in T cell immunology and vaccinology. Database (Oxford). 2014; 2014:bau031.
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Large-scale analysis of B-cell epitopes on influenza virus hemagglutinin - implications for cross-reactivity of neutralizing antibodies. Front Immunol. 2014; 5:38.
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Dynamic control of ß1 integrin adhesion by the plexinD1-sema3E axis. Proc Natl Acad Sci U S A. 2014 Jan 07; 111(1):379-84.
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Strict Major Histocompatibility Complex Molecule Class-Specific Binding by Co-Receptors Enforces MHC-Restricted aß?TCR Recognition during T Lineage Subset Commitment. Front Immunol. 2013 Nov 22; 4:383.
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Plxnd1 expression in thymocytes regulates their intrathymic migration while that in thymic endothelium impacts medullary topology. Front Immunol. 2013; 4:392.
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Disruption of helix-capping residues 671 and 674 reveals a role in HIV-1 entry for a specialized hinge segment of the membrane proximal external region of gp41. J Mol Biol. 2014 Mar 06; 426(5):1095-108.
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Immunogenicity of membrane-bound HIV-1 gp41 membrane-proximal external region (MPER) segments is dominated by residue accessibility and modulated by stereochemistry. J Biol Chem. 2013 Nov 01; 288(44):31888-901.
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BlockLogo: visualization of peptide and sequence motif conservation. J Immunol Methods. 2013 Dec 31; 400-401:37-44.
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Identification of human leucocyte antigen (HLA)-A*0201-restricted cytotoxic T lymphocyte epitopes derived from HLA-DOß as a novel target for multiple myeloma. Br J Haematol. 2013 Nov; 163(3):343-51.
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Anti-HIV IgA isotypes: differential virion capture and inhibition of transcytosis are linked to prevention of mucosal R5 SHIV transmission. AIDS. 2013 Jun 01; 27(9):F13-20.
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Pillars article: Separation of functional subsets of human T cells by a monoclonal antibody. Proc. Natl. Acad. Sci. 1979. 76: 4061-4065. J Immunol. 2013 Jun 01; 190(11):5346-50.
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Pillars article: Monoclonal antibodies defining distinctive human T cell surface antigens. Science. 1979. 206: 347-349. J Immunol. 2013 Jun 01; 190(11):5351-3.
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Revisiting the putative TCR Ca dimerization model through structural analysis. Front Immunol. 2013; 4:16.
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The structural basis of aß T-lineage immune recognition: TCR docking topologies, mechanotransduction, and co-receptor function. Immunol Rev. 2012 Nov; 250(1):102-19.
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Ultra-high resolution HLA genotyping and allele discovery by highly multiplexed cDNA amplicon pyrosequencing. BMC Genomics. 2012 Aug 06; 13:378.
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Identification and validation of reference genes for expression studies in human keratinocyte cell lines treated with and without interferon-? - a method for qRT-PCR reference gene determination. Exp Dermatol. 2012 Aug; 21(8):625-9.
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Stochastic optical active rheology. Appl Phys Lett. 2012 Jul 16; 101(3):31902.
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Pharmacology: A false sense of non-self. Nature. 2012 Jun 27; 486(7404):479-81.
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TCR Mechanobiology: Torques and Tunable Structures Linked to Early T Cell Signaling. Front Immunol. 2012; 3:76.
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Conservation analysis of dengue virus T-cell epitope-based vaccine candidates using Peptide block entropy. Front Immunol. 2011; 2:69.
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Direct identification of an HPV-16 tumor antigen from cervical cancer biopsy specimens. Front Immunol. 2011; 2:75.
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FLAVIdB: A data mining system for knowledge discovery in flaviviruses with direct applications in immunology and vaccinology. Immunome Res. 2011; 7(3):1-9.
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PB1-F2 Finder: scanning influenza sequences for PB1-F2 encoding RNA segments. BMC Bioinformatics. 2011; 12 Suppl 13:S6.
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A new angle on TCR activation. Immunity. 2011 Nov 23; 35(5):658-60.
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Antibody mechanics on a membrane-bound HIV segment essential for GP41-targeted viral neutralization. Nat Struct Mol Biol. 2011 Oct 16; 18(11):1235-43.
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Impaired B cell development and function in the absence of IkappaBNS. J Immunol. 2011 Oct 15; 187(8):3942-52.
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Dana-Farber repository for machine learning in immunology. J Immunol Methods. 2011 Nov 30; 374(1-2):18-25.
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Impaired tumor antigen processing by immunoproteasome-expressing CD40-activated B cells and dendritic cells. Cancer Immunol Immunother. 2011 Jun; 60(6):857-67.
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A conserved hydrophobic patch on Vß domains revealed by TCRß chain crystal structures: Implications for pre-TCR dimerization. Front Immunol. 2011; 2:5.
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Induction of anti-tumor cytotoxic T cell responses through PLGA-nanoparticle mediated antigen delivery. Biomaterials. 2011 May; 32(14):3666-78.
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Molecular T cell biology?--?basic and translational challenges in the twenty-first century. Front Immunol. 2011; 2:3.
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FLAVIdB: A data mining system for knowledge discovery in flaviviruses with direct applications in immunology and vaccinology. Immunome Res. 2011; 7(3).
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MULTIPRED2: a computational system for large-scale identification of peptides predicted to bind to HLA supertypes and alleles. J Immunol Methods. 2011 Nov 30; 374(1-2):53-61.
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Molecular detection of targeted major histocompatibility complex I-bound peptides using a probabilistic measure and nanospray MS3 on a hybrid quadrupole-linear ion trap. Anal Chem. 2010 Nov 01; 82(21):9090-9.
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Distinctive CD3 heterodimeric ectodomain topologies maximize antigen-triggered activation of alpha beta T cell receptors. J Immunol. 2010 Sep 01; 185(5):2951-9.
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A conserved E7-derived cytotoxic T lymphocyte epitope expressed on human papillomavirus 16-transformed HLA-A2+ epithelial cancers. J Biol Chem. 2010 Sep 17; 285(38):29608-22.
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Significant impact of sequence variations in the nucleoprotein on CD8 T cell-mediated cross-protection against influenza A virus infections. PLoS One. 2010 May 11; 5(5):e10583.
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Graft-versus-leukemia antigen CML66 elicits coordinated B-cell and T-cell immunity after donor lymphocyte infusion. Clin Cancer Res. 2010 May 15; 16(10):2729-39.
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Interactions between lipids and human anti-HIV antibody 4E10 can be reduced without ablating neutralizing activity. J Virol. 2010 Jan; 84(2):1076-88.
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The alphabeta T cell receptor is an anisotropic mechanosensor. J Biol Chem. 2009 Nov 06; 284(45):31028-37.
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Pyrin Modulates the Intracellular Distribution of PSTPIP1. PLoS One. 2009 Jul 07; 4(7):e6147.
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Broadly neutralizing anti-HIV-1 antibodies disrupt a hinge-related function of gp41 at the membrane interface. Proc Natl Acad Sci U S A. 2009 Jun 02; 106(22):9057-62.
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Immunogenicity of recombinant Modified Vaccinia Ankara following a single or multi-dose vaccine regimen in rhesus monkeys. Vaccine. 2009 Mar 04; 27(10):1549-56.
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The heterogeneity of human antibody responses to vaccinia virus revealed through use of focused protein arrays. Vaccine. 2009 Feb 18; 27(8):1154-65.
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Evaluation of MHC-II peptide binding prediction servers: applications for vaccine research. BMC Bioinformatics. 2008 Dec 12; 9 Suppl 12:S22.
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PlexinD1 glycoprotein controls migration of positively selected thymocytes into the medulla. Immunity. 2008 Dec 19; 29(6):888-98.
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Structural and functional evidence that Nck interaction with CD3epsilon regulates T-cell receptor activity. J Mol Biol. 2008 Jul 18; 380(4):704-16.
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PVS: a web server for protein sequence variability analysis tuned to facilitate conserved epitope discovery. Nucleic Acids Res. 2008 Jul 01; 36(Web Server issue):W35-41.
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Evaluation of MHC class I peptide binding prediction servers: applications for vaccine research. BMC Immunol. 2008 Mar 16; 9:8.
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Immunodominant-peptide recognition: beta testing TCRalphabeta. Immunity. 2008 Feb; 28(2):139-41.
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Polymer-supported lipid shells, onions, and flowers. Soft Matter. 2008; 4(9):1787-1791.
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HIV-1 broadly neutralizing antibody extracts its epitope from a kinked gp41 ectodomain region on the viral membrane. Immunity. 2008 Jan; 28(1):52-63.
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Functional role for I kappa BNS in T cell cytokine regulation as revealed by targeted gene disruption. J Immunol. 2007 Aug 01; 179(3):1681-92.
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CTL recognition of a protective immunodominant influenza A virus nucleoprotein epitope utilizes a highly restricted Vbeta but diverse Valpha repertoire: functional and structural implications. J Mol Biol. 2007 Sep 14; 372(2):535-48.
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Major neutralizing sites on vaccinia virus glycoprotein B5 are exposed differently on variola virus ortholog B6. J Virol. 2007 Aug; 81(15):8131-9.
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Importance of the CD3gamma ectodomain terminal beta-strand and membrane proximal stalk in thymic development and receptor assembly. J Immunol. 2007 Mar 15; 178(6):3668-79.
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Proteome informatics for cancer research: from molecules to clinic. Proteomics. 2007 Mar; 7(6):976-91.
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Definition of MHC supertypes through clustering of MHC peptide-binding repertoires. Methods Mol Biol. 2007; 409:163-73.
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Prediction of peptide-MHC binding using profiles. Methods Mol Biol. 2007; 409:185-200.
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Immunogenicity of recombinant human immunodeficiency virus type 1-like particles expressing gp41 derivatives in a pre-fusion state. Vaccine. 2007 Jun 28; 25(27):5102-14.
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The TCR C beta FG loop regulates alpha beta T cell development. J Immunol. 2006 Jun 01; 176(11):6812-23.
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Elicitation from virus-naive individuals of cytotoxic T lymphocytes directed against conserved HIV-1 epitopes. Med Immunol. 2006 May 18; 5:1.
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CD2BP1 modulates CD2-dependent T cell activation via linkage to protein tyrosine phosphatase (PTP)-PEST. J Immunol. 2006 May 15; 176(10):5898-907.
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Recognition and classification of histones using support vector machine. J Comput Biol. 2006 Jan-Feb; 13(1):102-12.
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Structural and mutational analyses of a CD8alphabeta heterodimer and comparison with the CD8alphaalpha homodimer. Immunity. 2005 Dec; 23(6):661-71.
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CD8 alpha alpha homodimer expression and role in CD8 T cell memory generation during influenza virus A infection in mice. Eur J Immunol. 2005 Nov; 35(11):3103-10.
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Prediction of methylated CpGs in DNA sequences using a support vector machine. FEBS Lett. 2005 Aug 15; 579(20):4302-8.
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PEPVAC: a web server for multi-epitope vaccine development based on the prediction of supertypic MHC ligands. Nucleic Acids Res. 2005 Jul 01; 33(Web Server issue):W138-42.
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Design, expression, and immunogenicity of a soluble HIV trimeric envelope fragment adopting a prefusion gp41 configuration. J Biol Chem. 2005 Jun 17; 280(24):23138-46.
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Molecular basis for the high affinity interaction between the thymic leukemia antigen and the CD8alphaalpha molecule. J Immunol. 2005 Mar 15; 174(6):3501-7.
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Antiviral chemotherapy facilitates control of poxvirus infections through inhibition of cellular signal transduction. J Clin Invest. 2005 Feb; 115(2):379-87.
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EPIMHC: a curated database of MHC-binding peptides for customized computational vaccinology. Bioinformatics. 2005 May 01; 21(9):2140-1.
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Comparison of HIV Type 1 ADA gp120 monomers versus gp140 trimers as immunogens for the induction of neutralizing antibodies. AIDS Res Hum Retroviruses. 2005 Jan; 21(1):58-67.
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Crystal structures of murine MHC Class I H-2 D(b) and K(b) molecules in complex with CTL epitopes from influenza A virus: implications for TCR repertoire selection and immunodominance. J Mol Biol. 2005 Feb 04; 345(5):1099-110.
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New approaches to eliciting protective immunity through T cell repertoire manipulation: the concept of thymic vaccination. Med Immunol. 2004 Dec 08; 3(1):2.
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Solution structure of the CD3epsilondelta ectodomain and comparison with CD3epsilongamma as a basis for modeling T cell receptor topology and signaling. Proc Natl Acad Sci U S A. 2004 Nov 30; 101(48):16867-72.
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In vivo selection of a TCR Vbeta repertoire directed against an immunodominant influenza virus CTL epitope. Int Immunol. 2004 Nov; 16(11):1549-59.
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Enhancement to the RANKPEP resource for the prediction of peptide binding to MHC molecules using profiles. Immunogenetics. 2004 Sep; 56(6):405-19.
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Peptide variants of viral CTL epitopes mediate positive selection and emigration of Ag-specific thymocytes in vivo. J Immunol. 2004 Jul 15; 173(2):1140-50.
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A chimeric protein of simian immunodeficiency virus envelope glycoprotein gp140 and Escherichia coli aspartate transcarbamoylase. J Virol. 2004 May; 78(9):4508-16.
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Biochemical and functional analysis of smallpox growth factor (SPGF) and anti-SPGF monoclonal antibodies. J Biol Chem. 2004 Jun 11; 279(24):25838-48.
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Phage-displayed libraries of peptide/major histocompatibility complexes. Eur J Immunol. 2004 Feb; 34(2):598-607.
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Gene expression analysis of thymocyte selection in vivo. Int Immunol. 2003 Oct; 15(10):1237-48.
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Structural investigations of a GYF domain covalently linked to a proline-rich peptide. J Biomol NMR. 2003 Oct; 27(2):143-9.
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Genome-wide characterization of a viral cytotoxic T lymphocyte epitope repertoire. J Biol Chem. 2003 Nov 14; 278(46):45135-44.
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Sequence variability analysis of human class I and class II MHC molecules: functional and structural correlates of amino acid polymorphisms. J Mol Biol. 2003 Aug 15; 331(3):623-41.
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CD2 engagement induces dendritic cell activation: implications for immune surveillance and T-cell activation. Blood. 2003 Sep 01; 102(5):1745-52.
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CD2BP3, CIN85 and the structurally related adaptor protein CMS bind to the same CD2 cytoplasmic segment, but elicit divergent functional activities. Int Immunol. 2003 Mar; 15(3):313-29.
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The crystal structure of a TL/CD8alphaalpha complex at 2.1 A resolution: implications for modulation of T cell activation and memory. Immunity. 2003 Feb; 18(2):205-15.
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Disparate peptide-dependent thymic selection outcomes in beta2M-deficient mice versus TAP-1-deficient mice: implications for repertoire formation. Eur J Immunol. 2003 Feb; 33(2):368-80.
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Sialic acid capping of CD8beta core 1-O-glycans controls thymocyte-major histocompatibility complex class I interaction. J Biol Chem. 2003 Feb 28; 278(9):7240-6.
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Dynamic interaction of CD2 with the GYF and the SH3 domain of compartmentalized effector molecules. EMBO J. 2002 Nov 15; 21(22):5985-95.
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Peptide-independent folding and CD8 alpha alpha binding by the nonclassical class I molecule, thymic leukemia antigen. J Immunol. 2002 Nov 15; 169(10):5708-14.
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Prediction of MHC class I binding peptides using profile motifs. Hum Immunol. 2002 Sep; 63(9):701-9.
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Involvement of the TCR Cbeta FG loop in thymic selection and T cell function. J Exp Med. 2002 Jun 03; 195(11):1419-31.
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CD2 molecules redistribute to the uropod during T cell scanning: implications for cellular activation and immune surveillance. Proc Natl Acad Sci U S A. 2002 May 28; 99(11):7582-7.
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Structural basis of T cell recognition of peptides bound to MHC molecules. Mol Immunol. 2002 May; 38(14):1039-49.
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Peptide-induced negative selection of thymocytes activates transcription of an NF-kappa B inhibitor. Mol Cell. 2002 Mar; 9(3):637-48.
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CD2 facilitates differentiation of CD4 Th cells without affecting Th1/Th2 polarization. J Immunol. 2002 Feb 01; 168(3):1113-22.
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T cell responses modulated through interaction between CD8alphaalpha and the nonclassical MHC class I molecule, TL. Science. 2001 Nov 30; 294(5548):1936-9.
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Developmentally regulated glycosylation of the CD8alphabeta coreceptor stalk modulates ligand binding. Cell. 2001 Nov 16; 107(4):501-12.
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Critical role of NK but not NKT cells in acute rejection of parental bone marrow cells in F1 hybrid mice. Eur J Immunol. 2001 Nov; 31(11):3147-52.
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A naturally processed mitochondrial self-peptide in complex with thymic MHC molecules functions as a selecting ligand for a viral-specific T cell receptor. J Exp Med. 2001 Oct 01; 194(7):883-92.
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Molecular dissection of the CD2-CD58 counter-receptor interface identifies CD2 Tyr86 and CD58 Lys34 residues as the functional "hot spot". J Mol Biol. 2001 Sep 28; 312(4):711-20.
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The stoichiometry of trimeric SIV glycoprotein interaction with CD4 differs from that of anti-envelope antibody Fab fragments. J Biol Chem. 2001 Nov 16; 276(46):42667-76.
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Crystal structure of the human CD4 N-terminal two-domain fragment complexed to a class II MHC molecule. Proc Natl Acad Sci U S A. 2001 Sep 11; 98(19):10799-804.
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The CD8alphabeta co-receptor on double-positive thymocytes binds with differing affinities to the products of distinct class I MHC loci. Eur J Immunol. 2001 Sep; 31(9):2791-9.
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Expression, purification, and characterization of recombinant HIV gp140. The gp41 ectodomain of HIV or simian immunodeficiency virus is sufficient to maintain the retroviral envelope glycoprotein as a trimer. J Biol Chem. 2001 Oct 26; 276(43):39577-85.
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Expression of endothelial nitric oxide synthase in the ischemic penumbra: relationship to expression of neuronal nitric oxide synthase and vascular endothelial growth factor. Brain Res. 2001 Aug 03; 909(1-2):1-7.
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Mechanisms contributing to T cell receptor signaling and assembly revealed by the solution structure of an ectodomain fragment of the CD3 epsilon gamma heterodimer. Cell. 2001 Jun 29; 105(7):913-23.
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Dynamic recruitment of human CD2 into lipid rafts. Linkage to T cell signal transduction. J Biol Chem. 2001 Jun 01; 276(22):18775-85.
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A critical role for CD2 in both thymic selection events and mature T cell function. J Immunol. 2001 Feb 15; 166(4):2394-403.
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T Cell Receptor Binding to a pMHCII Ligand Is Kinetically Distinct from and Independent of CD4. J Biol Chem. 2001 Feb 23; 276(8):5659-67.
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A critical role for p59(fyn) in CD2-based signal transduction. Eur J Immunol. 2000 Dec; 30(12):3507-15.
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Clonal analysis of B cell growth and differentiation activities induced from T lymphocytes upon triggering of T3-Ti and T11 pathways. J Immunol. 1985 Sep; 135(3):1884-90.
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The human T lymphocyte receptor complex for antigen and MHC. Behring Inst Mitt. 1985 Aug; (77):1-21.
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Production and characterization of antibody probes directed at constant regions of the alpha and beta subunit of the human T cell receptor. Eur J Immunol. 1985 Aug; 15(8):821-7.
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MHC class II gene products specific autoreactive T cell clones provide inducer as well as amplifier function for B cell Ig production. Behring Inst Mitt. 1985 Aug; (77):93-104.
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Genes encoding the T-cell receptor alpha and beta subunits are transcribed in an ordered manner during intrathymic ontogeny. Proc Natl Acad Sci U S A. 1985 Aug; 82(16):5510-4.
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Regional location of T cell receptor gene Ti alpha on human chromosome 14. J Exp Med. 1985 Jul 01; 162(1):387-92.
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The role of interleukin 2 and T11 E rosette antigen in activation and proliferation of human NK clones. J Immunol. 1985 Jul; 135(1):672-8.
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Analysis of T-cell receptor gene rearrangement and expression in human natural killer clones. Science. 1985 Jun 28; 228(4707):1540-3.
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Molecular aspects of human T lymphocyte antigen recognition. Transplantation. 1985 Jun; 39(6):571-82.
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Molecular analysis of T cell receptor (Ti) variable region (V) gene expression. Evidence that a single Ti beta V gene family can be used in formation of V domains on phenotypically and functionally diverse T cell populations. J Exp Med. 1985 Jun 01; 161(6):1326-43.
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In vivo activated T lymphocytes in the peripheral blood and cerebrospinal fluid of patients with multiple sclerosis. N Engl J Med. 1985 May 30; 312(22):1405-11.
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The human T-cell receptor. J Clin Immunol. 1985 May; 5(3):141-57.
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The human T-cell receptor. Structure and function. N Engl J Med. 1985 Apr 25; 312(17):1100-11.
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Systemic lupus erythematosus: delineation of subpopulations by clinical, serologic, and T cell subset analysis. Am J Med Sci. 1985 Apr; 289(4):139-47.
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Functional and phenotypic studies of Japanese adult T cell leukemia cells. J Clin Invest. 1985 Mar; 75(3):836-43.
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A molecular basis for thymic selection: regulation of T11 induced thymocyte expansion by the T3-Ti antigen/MHC receptor pathway. Immunol Today. 1985 Mar; 6(3):75-9.
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Structural invariance of T4 molecules from T cell clones of different antigen and major histocompatibility complex specificities. Eur J Immunol. 1985 Mar; 15(3):291-5.
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Molecular analysis of the human T-cell-antigen receptor. Biochem Soc Trans. 1985 Feb; 13(1):6-10.
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Activation of human thymocytes via the 50KD T11 sheep erythrocyte binding protein induces the expression of interleukin 2 receptors on both T3+ and T3- populations. J Immunol. 1985 Jan; 134(1):330-5.
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[Phorbol diester induces phenotypic and functional changes in human T-lymphocyte clones]. C R Acad Sci III. 1985; 301(4):121-4.
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Genes encoding the Ti beta subunit of the antigen/MHC receptor undergo rearrangement during intrathymic ontogeny prior to surface T3-Ti expression. Cell. 1984 Dec; 39(2 Pt 1):261-6.
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Calcium dependency of antigen-specific (T3-Ti) and alternative (T11) pathways of human T-cell activation. Proc Natl Acad Sci U S A. 1984 Nov; 81(21):6836-40.
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Homology of Ti alpha-subunit of a T-cell antigen-MHC receptor with immunoglobulin. Nature. 1984 Nov 15-21; 312(5991):269-71.
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Chromosomal location of human T-cell receptor gene Ti beta. Science. 1984 Oct 19; 226(4672):348-9.
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T3-Ti receptor triggering of T8+ suppressor T cells leads to unresponsiveness to interleukin-2. Nature. 1984 Oct 11-17; 311(5986):565-7.
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Clonotypic surface structure on human T lymphocytes: functional and biochemical analysis of the antigen receptor complex. Immunol Rev. 1984 Oct; 81:95-129.
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Cellular interaction between subsets of T8 population for maximal suppression of antigen-specific antibody response. Cell Immunol. 1984 Oct 01; 88(1):75-84.
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T cell regulation of myelopoiesis: analysis at a clonal level. J Immunol. 1984 Oct; 133(4):1863-8.
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Ta1, a novel 105 KD human T cell activation antigen defined by a monoclonal antibody. J Immunol. 1984 Sep; 133(3):1250-6.
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Identification of a 140-kDa activation antigen as a target structure for a series of human cloned natural killer cell lines. Eur J Immunol. 1984 Sep; 14(9):844-52.
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Functional isotypes are not encoded by the constant region genes of the beta subunit of the T cell receptor for antigen/major histocompatibility complex. J Exp Med. 1984 Sep 01; 160(3):947-52.
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Surface molecules involved in self-recognition and T cell activation in the autologous mixed lymphocyte reaction. J Immunol. 1984 Sep; 133(3):1093-100.
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Natural killer-like activity mediated by activated T lymphocytes. Cell Immunol. 1984 Sep; 87(2):327-39.
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Natural killer-like function of activated T lymphocytes: differential blocking effects of monoclonal antibodies specific for a 90-kDa clonotypic structure. Cell Immunol. 1984 Jul; 86(2):381-92.
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Purification and NH2-terminal amino acid sequencing of the beta subunit of a human T-cell antigen receptor. Proc Natl Acad Sci U S A. 1984 Jun; 81(12):3851-5.
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Total lymphoid irradiation therapy in refractory rheumatoid arthritis. Fifteen- to forty-month followup. Arthritis Rheum. 1984 May; 27(5):481-8.
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Characterization of human thymic epithelial cells grown in serum-free medium. Clin Immunol Immunopathol. 1984 Apr; 31(1):56-64.
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An alternative pathway of T-cell activation: a functional role for the 50 kd T11 sheep erythrocyte receptor protein. Cell. 1984 Apr; 36(4):897-906.
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Triggering of the T3-Ti antigen-receptor complex results in clonal T-cell proliferation through an interleukin 2-dependent autocrine pathway. Proc Natl Acad Sci U S A. 1984 Mar; 81(5):1509-13.
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Relationship between systemic lupus erythematosus T cell subsets, anti-T cell antibodies, and T cell functions. J Clin Invest. 1984 Mar; 73(3):689-700.
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Delineation of an immunoregulatory amplifier population recognizing autologous Ia molecules. Analysis with human T cell clones. J Exp Med. 1984 Feb 01; 159(2):559-76.
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Human T-cell subsets in health and disease. Springer Semin Immunopathol. 1984; 7(1):9-18.
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Immunoregulatory subsets of the T helper and T suppressor cell populations in homosexual men with chronic unexplained lymphadenopathy. J Clin Invest. 1984 Jan; 73(1):191-201.
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The human T-cell receptor. Annu Rev Immunol. 1984; 2:23-50.
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Reactivity of inducer cell subsets and T8-cell activation during the human autologous mixed lymphocyte reaction. Clin Immunol Immunopathol. 1984 Jan; 30(1):117-28.
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Identification of the receptor for antigen and major histocompatibility complex on human inducer T lymphocytes. Science. 1983 Dec 16; 222(4629):1239-42.
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Treatment of acute renal allograft rejection with monoclonal anti-T12 antibody. Transplantation. 1983 Dec; 36(6):620-6.
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Identification of a clonally restricted 90 kD heterodimer on two human cloned natural killer cell lines. Its role in cytotoxic effector function. J Exp Med. 1983 Nov 01; 158(5):1547-60.
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Peptide variability exists within alpha and beta subunits of the T cell receptor for antigen. J Exp Med. 1983 Oct 01; 158(4):1368-73.
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Immunohistochemical staining of human brain with monoclonal antibodies that identify lymphocytes, monocytes, and the Ia antigen. J Neuroimmunol. 1983 Oct; 5(2):197-205.
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The human T cell receptor: appearance in ontogeny and biochemical relationship of alpha and beta subunits on IL-2 dependent clones and T cell tumors. Cell. 1983 Oct; 34(3):717-26.
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Generation of antigen-specific suppressor cells in vitro in man. J Immunol. 1983 Sep; 131(3):1209-13.
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Immunoregulatory human T lymphocytes triggered as a consequence of viral infection: clonal analysis of helper, suppressor inducer and suppressor effector cell populations. J Immunol. 1983 Sep; 131(3):1167-72.
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Antigen-like effects of monoclonal antibodies directed at receptors on human T cell clones. J Exp Med. 1983 Sep 01; 158(3):988-93.
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Comparison of T3-associated 49- and 43-kilodalton cell surface molecules on individual human T-cell clones: evidence for peptide variability in T-cell receptor structures. Proc Natl Acad Sci U S A. 1983 Jul; 80(13):4104-8.
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Contrasting effects of cyclophosphamide and prednisolone on the phenotype of human peripheral blood leukocytes. Clin Immunol Immunopathol. 1983 Jul; 28(1):101-14.
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Human cytotoxic T cell clones directed at autologous virus-transformed targets: further evidence for linkage of genetic restriction to T4 and T8 surface glycoproteins. J Immunol. 1983 Jul; 131(1):186-90.
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Evidence for the T3-associated 90K heterodimer as the T-cell antigen receptor. Nature. 1983 Jun 30; 303(5920):808-10.
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Identification of circulating maternal T and B lymphocytes in uncomplicated severe combined immunodeficiency by HLA typing of subpopulations of T cells separated by the fluorescence-activated cell sorter and of Epstein Barr virus-derived B cell lines. J Immunol. 1983 Jun; 130(6):2493-5.
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Multiple sclerosis. Distribution of T cells, T cell subsets and Ia-positive macrophages in lesions of different ages. J Neuroimmunol. 1983 Jun; 4(3):201-21.
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CSF cells in multiple sclerosis: monoclonal antibody analysis and relationship to peripheral blood T-cell subsets. Neurology. 1983 May; 33(5):575-9.
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T-cell surface antigens in a patient with blast crisis of chronic myeloid leukemia. Blood. 1983 Apr; 61(4):640-4.
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Circulating lymphocyte populations in Hodgkin's disease after mantle and paraaortic irradiation. Blood. 1983 Apr; 61(4):705-8.
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T lymphocyte surface antigens in primates. Eur J Immunol. 1983 Apr; 13(4):345-7.
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Immunoregulatory T-cells and lymphocytotoxic antibodies in active multiple sclerosis: weekly analysis over a six-month period. Ann Neurol. 1983 Apr; 13(4):418-25.
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Clonotypic structures involved in antigen-specific human T cell function. Relationship to the T3 molecular complex. J Exp Med. 1983 Feb 01; 157(2):705-19.
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Multiple sclerosis: distribution of T cell subsets within active chronic lesions. Science. 1983 Jan 21; 219(4582):308-10.
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Phenotypic and functional heterogeneity of human cloned natural killer cell lines. Nature. 1983 Jan 13; 301(5896):158-60.
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The human T cell receptor: analysis with cytotoxic T cell clones. Immunol Rev. 1983; 74:83-112.
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Direct demonstration of the human suppressor inducer subset by anti-T cell antibodies. J Immunol. 1983 Jan; 130(1):157-61.
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The delineation of antigen receptors on human T lymphocytes. Immunol Today. 1983 Jan; 4(1):5-8.
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Monoclonal anti-T12 antibody as therapy for renal allograft rejection. Trans Assoc Am Physicians. 1983; 96:84-92.
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Monoclonal anti-T cell antibodies are applicable to the study of inflammatory infiltrates in the central nervous system. J Neuroimmunol. 1982 Dec; 3(4):365-73.
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T-cell subsets in human autoimmune diseases. Neurology. 1982 Nov; 32(11):1320-1.
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Surface structures involved in target recognition by human cytotoxic T lymphocytes. Science. 1982 Oct 29; 218(4571):471-3.
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Reconstitution after transplantation with T-lymphocyte-depleted HLA haplotype-mismatched bone marrow for severe combined immunodeficiency. Proc Natl Acad Sci U S A. 1982 Oct; 79(19):6047-51.
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Antigen recognition by human T lymphocytes is linked to surface expression of the T3 molecular complex. Cell. 1982 Oct; 30(3):735-43.
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Generation of a cloned NK cell line derived from the "null cell" fraction of human peripheral blood. J Immunol. 1982 Sep; 129(3):1299-305.
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Acquisition of immune competence by a subset of human cortical thymocytes expressing mature T cell antigens. J Immunol. 1982 Sep; 129(3):1054-60.
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Cellular origin of interleukin 2 (IL 2) in man: evidence for stimulus-restricted IL 2 production by T4+ and T8+ T lymphocytes. J Immunol. 1982 Sep; 129(3):1076-9.
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Clonal analysis of human cytotoxic T lymphocytes: T4+ and T8+ effector T cells recognize products of different major histocompatibility complex regions. Proc Natl Acad Sci U S A. 1982 Jul; 79(14):4395-9.
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Childhood multiple sclerosis: clinical features and demonstration of changes in T cell subsets with disease activity. Ann Neurol. 1982 May; 11(5):463-8.
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T-cell ratios in homosexuals. Lancet. 1982 Apr 17; 1(8277):908.
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Immunoregulatory abnormalities in mucocutaneous lymph node syndrome. Clin Immunol Immunopathol. 1982 Apr; 23(1):100-12.
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Communicative interactions between subpopulations of human T lymphocytes required for generation of suppressor effector function in a primary antibody response. J Immunol. 1982 Apr; 128(4):1645-50.
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The characterization and function of human immunoregulatory T lymphocyte subsets. Pharmacol Rev. 1982 Mar; 34(1):17-22.
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Alterations of T-cell subsets in primary biliary cirrhosis. Clin Exp Immunol. 1982 Feb; 47(2):351-8.
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Comparison in T- and B-cell markers in patients with Sjögren's syndrome and systemic lupus erythematosus. Clin Immunol Immunopathol. 1982 Feb; 22(2):270-8.
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In situ immunologic characterization of cellular constituents in lymph nodes and spleens involved by Hodgkin's disease. Blood. 1982 Feb; 59(2):226-32.
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Heterogeneity of human T4+ inducer T cells defined by a monoclonal antibody that delineates two functional subpopulations. J Immunol. 1982 Jan; 128(1):463-8.
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Antibody directed at a surface structure inhibits cytolytic but not suppressor function of human T lymphocytes. Nature. 1981 Nov 12; 294(5837):168-70.
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Comparative expression of T9, T10, and Ia antigens on activated human T cell subsets. Hum Immunol. 1981 Nov; 3(3):247-59.
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Derivation of human T-cell leukemias. Cancer Res. 1981 Nov; 41(11 Pt 2):4767-70.
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A rapid method for separating functionally intact human T lymphocytes with monoclonal antibodies. Clin Immunol Immunopathol. 1981 Nov; 21(2):257-66.
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Expression of a 26,000-dalton glycoprotein on activated human T cells. Cell Immunol. 1981 Oct; 64(1):192-9.
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New concepts of immunodeficiency. Am J Med. 1981 Oct; 71(4):511-3.
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Antibody-dependent cellular cytotoxicity and natural-killer-like activity are mediated by subsets of activated T cells. Clin Immunol Immunopathol. 1981 Oct; 21(1):134-40.
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Lymphoid subpopulations of peripheral blood and spleen in untreated Hodgkin's disease. Cancer. 1981 Sep 01; 48(5):1170-6.
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Abnormalities of T cell maturation and regulation in human beings with immunodeficiency disorders. J Clin Invest. 1981 Sep; 68(3):699-705.
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Deficiency of suppressor T cells in the hyperimmunoglobulin E syndrome. J Clin Invest. 1981 Sep; 68(3):783-91.
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Primary in vitro anti-KLH antibody formation by peripheral blood lymphocytes in man: detection with a radioimmunoassay. J Immunol. 1981 Aug; 127(2):514-7.
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Severe combined immunodeficiency with quantitatively normal but abnormally differentiated T lymphocytes. J Pediatr. 1981 Aug; 99(2):261-4.
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Regulation of in vitro primary anti-DNP antibody production by functional subsets of T lymphocytes in man. J Immunol. 1981 Jul; 127(1):69-73.
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Cell surface characterization of malignant T cells from lymphoblastic lymphoma using monoclonal antibodies: evidence for phenotypic differences between malignant T cells from patients with acute lymphoblastic leukemia and lymphoblastic lymphoma. Blood. 1981 Jun; 57(6):1105-10.
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Immunodeficiency associated with loss of T4+ inducer T-cell function. N Engl J Med. 1981 Apr 02; 304(14):811-6.
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The characterization and function of human immunoregulatory T lymphocyte subsets. Immunol Today. 1981 Apr; 2(4):69-75.
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Biochemical studies of the human thymocyte cell-surface antigens T6, T9 and T10. Cell. 1981 Mar; 23(3):771-80.
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Autoantibody to an immunoregulatory inducer population in patients with juvenile rheumatoid arthritis. J Clin Invest. 1981 Mar; 67(3):753-61.
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Surface antigens on malignant Sézary and T-CLL cells correspond to those of mature T cells. Blood. 1981 Mar; 57(3):526-30.
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Characterization of T cell surface glycoproteins T 1 and T 3 present on all human peripheral T lymphocytes and functionally mature thymocytes. Eur J Immunol. 1981 Jan; 11(1):18-21.
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Distribution of T cell subsets in human lymph nodes. J Exp Med. 1981 Jan 01; 153(1):30-41.
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Diagnosis and treatment of human leukemias and lymphomas utilizing monoclonal antibodies. Prog Hematol. 1981; 12:187-225.
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Subpopulations of the T4+ inducer T cell subset in man: evidence for an amplifier population preferentially expressing Ia antigen upon activation. J Immunol. 1981 Jan; 126(1):67-70.
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Delineation of an effector population responsible for natural killing and antibody-dependent cellular cytotoxicity in man. Clin Immunol Immunopathol. 1981 Jan; 18(1):145-50.
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Alterations in immunoregulatory T cell subsets in active systemic lupus erythematosus. J Clin Invest. 1980 Nov; 66(5):1171-4.
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Location of T cell and major histocompatibility complex antigens in the human thymus. J Exp Med. 1980 Oct 01; 152(4):771-82.
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A monoclonal antibody blocking human T cell function. Eur J Immunol. 1980 Oct; 10(10):758-62.
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Human macrophage-lymphocyte interaction in proliferation to soluble antigen. I. Specific delection of lymphocyte proliferative activity on macrophage monolayers. Cell Immunol. 1980 Sep 15; 55(1):114-23.
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Delineation of a human T cell subset responsible for lepromin-induced suppression in leprosy patients. J Immunol. 1980 Sep; 125(3):1183-8.
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The cellular basis for viral-induced immunodeficiency: analysis by monoclonal antibodies. J Immunol. 1980 Sep; 125(3):1269-74.
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Current concepts in immunology: Regulation of the immune response--inducer and suppressor T-lymphocyte subsets in human beings. N Engl J Med. 1980 Aug 14; 303(7):370-3.
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Mature bone marrow erythroid burst-forming units do not require T cells for induction of erythropoietin-dependent differentiation. J Exp Med. 1980 Aug 01; 152(2):350-60.
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Characteristics of anti-T-cell antibodies in systemic lupus erythematosus: evidence for selective reactivity with normal suppressor cells defined by monoclonal antibodies. Clin Immunol Immunopathol. 1980 Aug; 16(4):474-84.
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Biochemical analysis of human T lymphocyte differentiation antigens T4 and T5. Science. 1980 Jul 25; 209(4455):520-1.
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Loss of suppressor T cells in active multiple sclerosis. Analysis with monoclonal antibodies. N Engl J Med. 1980 Jul 17; 303(3):125-9.
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Regulation of B cell immunoglobulin secretion by functional subsets of T lymphocytes in man. Eur J Immunol. 1980 Jul; 10(7):570-2.
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Heterogeneity of T-cell lymphoblastic malignancies. Blood. 1980 May; 55(5):806-10.
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Human T lymphocyte subpopulations defined by Fc receptors and monoclonal antibodies. A comparison. J Exp Med. 1980 Apr 01; 151(4):969-74.
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The differentiation and function of human T lymphocytes. Cell. 1980 Apr; 19(4):821-7.
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A monoclonal antibody reactive with human peripheral blood monocytes. J Immunol. 1980 Apr; 124(4):1943-8.
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T cell requirements for generation of helper factor(s) in man: analysis of the subsets involved. J Immunol. 1980 Apr; 124(4):1883-7.
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A monoclonal antibody reactive with the human cytotoxic/suppressor T cell subset previously defined by a heteroantiserum termed TH2. J Immunol. 1980 Mar; 124(3):1301-7.
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Discrete stages of human intrathymic differentiation: analysis of normal thymocytes and leukemic lymphoblasts of T-cell lineage. Proc Natl Acad Sci U S A. 1980 Mar; 77(3):1588-92.
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Absence of expression of Ia antigen on human cytotoxic T cells. Immunogenetics. 1980; 11(4):421-6.
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The T lymphoblastic malignancies. Cancer Chemother Pharmacol. 1980; 4(1):11-5.
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Further characterization of the human inducer T cell subset defined by monoclonal antibody. J Immunol. 1979 Dec; 123(6):2894-6.
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Ia determinants on human T-cell subsets defined by monoclonal antibody. Activation stimuli required for expression. J Exp Med. 1979 Dec 01; 150(6):1472-82.
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Abnormalities of immunoregulatory T cells in disorders of immune function. N Engl J Med. 1979 Nov 08; 301(19):1018-22.
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Monoclonal antibodies defining distinctive human T cell surface antigens. Science. 1979 Oct 19; 206(4416):347-9.
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Acute graft-versus-host disease in recipients of bone-marrow transplants from identical twin donors. Lancet. 1979 Oct 06; 2(8145):717-20.
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A monoclonal antibody with selective reactivity with functionally mature human thymocytes and all peripheral human T cells. J Immunol. 1979 Sep; 123(3):1312-7.
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Separation of functional subsets of human T cells by a monoclonal antibody. Proc Natl Acad Sci U S A. 1979 Aug; 76(8):4061-5.
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Subset derivation of T-cell acute lymphoblastic leukemia in man. J Clin Invest. 1979 Aug; 64(2):392-7.
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Phenotypic and functional distinctions between the TH2+ and JRA+ T cell subsets in man. J Immunol. 1979 Jul; 123(1):83-6.
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T-cell-subset characterization of human T-CLL. Blood. 1979 Jun; 53(6):1066-75.
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Aberrations of suppressor T cells in human graft-versus-host disease. N Engl J Med. 1979 May 10; 300(19):1061-8.
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Con A-inducible suppression of MLC: evidence for mediation by the TH2 + T cell subset in man. J Immunol. 1979 Apr; 122(4):1335-41.
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