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The Role of Long Noncoding RNAs in Glioblastoma: What the Neurosurgeon Should Know. Neurosurgery. 2023 Mar 07.
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Reduced time to imaging, length of stay, and hospital charges following implementation of a novel postoperative pathway for craniotomy. J Neurosurg. 2023 Jan 06; 1-12.
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Cerebellar High-Grade Glioma: A Translationally Oriented Review of the Literature. Cancers (Basel). 2022 Dec 28; 15(1).
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Dual Immunostimulatory Pathway Agonism through a Synthetic Nanocarrier Triggers Robust Anti-Tumor Immunity in Murine Glioblastoma. Adv Mater. 2023 Feb; 35(7):e2208782.
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The emerging field of oncolytic virus-based cancer immunotherapy. Trends Cancer. 2023 Feb; 9(2):122-139.
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Specific targeting of glioblastoma with an oncolytic virus expressing a cetuximab-CCL5 fusion protein via innate and adaptive immunity. Nat Cancer. 2022 11; 3(11):1318-1335.
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Variants of the adeno-associated virus serotype 9 with enhanced penetration of the blood-brain barrier in rodents and primates. Nat Biomed Eng. 2022 11; 6(11):1257-1271.
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Treat and repeat: oncolytic virus therapy for brain cancer. Nat Med. 2022 08; 28(8):1540-1542.
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Perturbing DDR signaling enhances cytotoxic effects of local oncolytic virotherapy and modulates the immune environment in glioma. Mol Ther Oncolytics. 2022 Sep 15; 26:275-288.
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Carole A. Miller, MD: Matriarch of the Ohio State University's Department of Neurosurgery. World Neurosurg. 2022 10; 166:33-38.
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STING activation promotes robust immune response and NK cell-mediated tumor regression in glioblastoma models. Proc Natl Acad Sci U S A. 2022 07 12; 119(28):e2111003119.
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Clinical utility of targeted next-generation sequencing assay in IDH-wildtype glioblastoma for therapy decision-making. Neuro Oncol. 2022 07 01; 24(7):1140-1149.
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The current state of glioma data registries. Neurooncol Adv. 2022 Jan-Dec; 4(1):vdac099.
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Combined immunotherapy with controlled interleukin-12 gene therapy and immune checkpoint blockade in recurrent glioblastoma: An open-label, multi-institutional phase I trial. Neuro Oncol. 2022 06 01; 24(6):951-963.
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Target receptor identification and subsequent treatment of resected brain tumors with encapsulated and engineered allogeneic stem cells. Nat Commun. 2022 05 19; 13(1):2810.
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Agent-based computational modeling of glioblastoma predicts that stromal density is central to oncolytic virus efficacy. iScience. 2022 Jun 17; 25(6):104395.
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NOTCH-Induced MDSC Recruitment after oHSV Virotherapy in CNS Cancer Models Modulates Antitumor Immunotherapy. Clin Cancer Res. 2022 04 01; 28(7):1460-1473.
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Advances in local therapy for glioblastoma - taking the fight to the tumour. Nat Rev Neurol. 2022 04; 18(4):221-236.
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Tumor-Associated Macrophages/Microglia in Glioblastoma Oncolytic Virotherapy: A Double-Edged Sword. Int J Mol Sci. 2022 Feb 04; 23(3).
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Immune Checkpoint Inhibition in GBM Primed with Radiation by Engineered Extracellular Vesicles. ACS Nano. 2022 02 22; 16(2):1940-1953.
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Activity of PD-1 blockade with nivolumab among patients with recurrent atypical/anaplastic meningioma: phase II trial results. Neuro Oncol. 2022 01 05; 24(1):101-113.
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Autoimmune Cytopenias and Dysregulated Immunophenotype Act as Warning Signs of Inborn Errors of Immunity: Results From a Prospective Study. Front Immunol. 2021; 12:790455.
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Systemic high-dose dexamethasone treatment may modulate the efficacy of intratumoral viral oncolytic immunotherapy in glioblastoma models. J Immunother Cancer. 2022 01; 10(1).
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Quantitative imaging of apoptosis following oncolytic virotherapy by magnetic resonance fingerprinting aided by deep learning. Nat Biomed Eng. 2022 05; 6(5):648-657.
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Glial and myeloid heterogeneity in the brain tumour microenvironment. Nat Rev Cancer. 2021 12; 21(12):786-802.
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The Evolving Role of Neurosurgical Intervention for Central Nervous System Tumors. Hematol Oncol Clin North Am. 2022 02; 36(1):63-75.
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Treatment of glioblastoma with current oHSV variants reveals differences in efficacy and immune cell recruitment. Mol Ther Oncolytics. 2021 Sep 24; 22:444-453.
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Evolution of the Neurosurgeon's Role in Clinical Trials for Glioblastoma: A Systematic Overview of the Clinicaltrials.Gov Database. Neurosurgery. 2021 07 15; 89(2):196-203.
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The Current Landscape of Oncolytic Herpes Simplex Viruses as Novel Therapies for Brain Malignancies. Viruses. 2021 06 17; 13(6).
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Neurosurgery Research and Education Foundation funding conversion to National Institutes of Health funding. J Neurosurg. 2022 Jan 01; 136(1):287-294.
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Cytomegalovirus infection of glioblastoma cells leads to NF-?B dependent upregulation of the c-MET oncogenic tyrosine kinase. Cancer Lett. 2021 08 10; 513:26-35.
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Role of surgery for glioblastoma: response to letters from Dr. Gerritsen and his colleagues and Dr. Vargas Lopez. Neuro Oncol. 2021 03 25; 23(3):506-507.
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Unique challenges for glioblastoma immunotherapy-discussions across neuro-oncology and non-neuro-oncology experts in cancer immunology. Meeting Report from the 2019 SNO Immuno-Oncology Think Tank. Neuro Oncol. 2021 03 25; 23(3):356-375.
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Oncolytic Virus Therapy Alters the Secretome of Targeted Glioblastoma Cells. Cancers (Basel). 2021 Mar 14; 13(6).
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Biographies of international women leaders in neurosurgery. Neurosurg Focus. 2021 03; 50(3):E19.
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Inhibitory CD161 receptor identified in glioma-infiltrating T cells by single-cell analysis. Cell. 2021 03 04; 184(5):1281-1298.e26.
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Therapeutic cancer vaccines for pediatric malignancies: advances, challenges, and emerging technologies. Neurooncol Adv. 2021 Jan-Dec; 3(1):vdab027.
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Targeting glioblastoma using a novel peptide specific to a deglycosylated isoform of brevican. Adv Ther (Weinh). 2021 Apr; 4(4).
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The nuclear DICER-circular RNA complex drives the deregulation of the glioblastoma cell microRNAome. Sci Adv. 2020 12; 6(51).
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HSV-1 Oncolytic Viruses from Bench to Bedside: An Overview of Current Clinical Trials. Cancers (Basel). 2020 Nov 26; 12(12).
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Redesigned reporter gene for improved proton exchange-based molecular MRI contrast. Sci Rep. 2020 11 26; 10(1):20664.
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Concurrent Dexamethasone Limits the Clinical Benefit of Immune Checkpoint Blockade in Glioblastoma. Clin Cancer Res. 2021 01 01; 27(1):276-287.
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Oncolytic HSV Vectors and Anti-Tumor Immunity. Curr Issues Mol Biol. 2021; 41:381-468.
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Glioblastoma in adults: a Society for Neuro-Oncology (SNO) and European Society of Neuro-Oncology (EANO) consensus review on current management and future directions. Neuro Oncol. 2020 08 17; 22(8):1073-1113.
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Letter: Adaptation Under Fire: Two Harvard Neurosurgical Services During the COVID-19 Pandemic. Neurosurgery. 2020 08 01; 87(2):E173-E177.
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National Institute of Neurological Disorders and Stroke: current funding status, opportunities, challenges, emerging scientific advances, and recommendations for neurosurgery. J Neurosurg. 2020 Jul 03; 1-6.
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A Platinum(IV) Prodrug-Perfluoroaryl Macrocyclic Peptide Conjugate Enhances Platinum Uptake in the Brain. J Med Chem. 2020 07 09; 63(13):6741-6747.
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Extracellular Vesicles Induce Mesenchymal Transition and Therapeutic Resistance in Glioblastomas through NF-?B/STAT3 Signaling. Adv Biosyst. 2020 12; 4(12):e1900312.
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Tumor Interferon Signaling Is Regulated by a lncRNA INCR1 Transcribed from the PD-L1 Locus. Mol Cell. 2020 06 18; 78(6):1207-1223.e8.
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Hypoxic Roadmap of Glioblastoma-Learning about Directions and Distances in the Brain Tumor Environment. Cancers (Basel). 2020 May 13; 12(5).
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Immune Escape Mediated by Exosomal PD-L1 in Cancer. Adv Biosyst. 2020 12; 4(12):e2000017.
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Editorial. COVID-19 and academic neurosurgery. J Neurosurg. 2020 Apr 17; 1-2.
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Mechanisms and therapeutic implications of hypermutation in gliomas. Nature. 2020 04; 580(7804):517-523.
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Cytomegalovirus Encephalopathy during Brain Tumor Irradiation. Clin Cancer Res. 2020 07 01; 26(13):3077-3078.
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KLF4K409Q-mutated meningiomas show enhanced hypoxia signaling and respond to mTORC1 inhibitor treatment. Acta Neuropathol Commun. 2020 04 03; 8(1):41.
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Preclinical Toxicology of rQNestin34.5v.2: An Oncolytic Herpes Virus with Transcriptional Regulation of the ICP34.5 Neurovirulence Gene. Mol Ther Methods Clin Dev. 2020 Jun 12; 17:871-893.
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Glioblastoma infiltration of both tumor- and virus-antigen specific cytotoxic T cells correlates with experimental virotherapy responses. Sci Rep. 2020 03 20; 10(1):5095.
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FASN Is a Biomarker Enriched in Malignant Glioma-Derived Extracellular Vesicles. Int J Mol Sci. 2020 Mar 12; 21(6).
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Targeting glioma-initiating cells via the tyrosine metabolic pathway. J Neurosurg. 2020 Feb 14; 134(3):721-732.
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Correction: Arming an Oncolytic Herpes Simplex Virus Type 1 with a Single-chain Fragment Variable Antibody against PD-1 for Experimental Glioblastoma Therapy. Clin Cancer Res. 2020 Feb 01; 26(3):758.
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GBM-Targeted oHSV Armed with Matrix Metalloproteinase 9 Enhances Anti-tumor Activity and Animal Survival. Mol Ther Oncolytics. 2019 Dec 20; 15:214-222.
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Letter: When Less is More: Dexamethasone Dosing for Brain Tumors. Neurosurgery. 2019 09 01; 85(3):E607-E608.
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Regulatable interleukin-12 gene therapy in patients with recurrent high-grade glioma: Results of a phase 1 trial. Sci Transl Med. 2019 08 14; 11(505).
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Characterization of single microvesicles in plasma from glioblastoma patients. Neuro Oncol. 2019 05 06; 21(5):606-615.
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Proteomic Analysis Implicates Vimentin in Glioblastoma Cell Migration. Cancers (Basel). 2019 Apr 03; 11(4).
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Radiation-Induced Targeted Nanoparticle-Based Gene Delivery for Brain Tumor Therapy. ACS Nano. 2019 04 23; 13(4):4028-4040.
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Imaging flow cytometry facilitates multiparametric characterization of extracellular vesicles in malignant brain tumours. J Extracell Vesicles. 2019; 8(1):1588555.
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Frameless Stereotactic Navigation during Insular Glioma Resection using Fusion of Three-Dimensional Rotational Angiography and Magnetic Resonance Imaging. World Neurosurg. 2019 Jun; 126:322-330.
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Cytomegalovirus promotes murine glioblastoma growth via pericyte recruitment and angiogenesis. J Clin Invest. 2019 03 11; 129(4):1671-1683.
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Molecular responses to immune checkpoint blockade in glioblastoma. Nat Med. 2019 03; 25(3):359-361.
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Pneumatosis Intestinalis After Molecular-Targeted Therapy. World Neurosurg. 2019 05; 125:312-315.
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The functional synergism of microRNA clustering provides therapeutically relevant epigenetic interference in glioblastoma. Nat Commun. 2019 01 25; 10(1):442.
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Amendments: Publisher Correction: An oncolytic herpesvirus expressing E-cadherin improves survival in mouse models of glioblastoma. Nat Biotechnol. 2019 01 03; 37(1):102.
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Viral and other therapies for recurrent glioblastoma: is a 24-month durable response unusual? Neuro Oncol. 2019 01 01; 21(1):14-25.
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Neoantigen vaccine generates intratumoral T cell responses in phase Ib glioblastoma trial. Nature. 2019 01; 565(7738):234-239.
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An oncolytic herpesvirus expressing E-cadherin improves survival in mouse models of glioblastoma. Nat Biotechnol. 2018 Nov 26.
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Viruses in cancer therapy - from benchwarmers to quarterbacks. Nat Rev Clin Oncol. 2018 11; 15(11):657-658.
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The multiple protective roles and molecular mechanisms of melatonin and its precursor N-acetylserotonin in targeting brain injury and liver damage and in maintaining bone health. Free Radic Biol Med. 2019 01; 130:215-233.
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Arming an Oncolytic Herpes Simplex Virus Type 1 with a Single-chain Fragment Variable Antibody against PD-1 for Experimental Glioblastoma Therapy. Clin Cancer Res. 2019 01 01; 25(1):290-299.
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A PDGFRa-driven mouse model of glioblastoma reveals a stathmin1-mediated mechanism of sensitivity to vinblastine. Nat Commun. 2018 08 06; 9(1):3116.
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Immunotherapy for glioblastoma: going viral. Nat Med. 2018 08; 24(8):1094-1096.
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Immune evasion mediated by PD-L1 on glioblastoma-derived extracellular vesicles. Sci Adv. 2018 03; 4(3):eaar2766.
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Toxicity and Efficacy of a Novel GADD34-expressing Oncolytic HSV-1 for the Treatment of Experimental Glioblastoma. Clin Cancer Res. 2018 06 01; 24(11):2574-2584.
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Endoscopic Endonasal Resection of a Suprasellar Pituitary Adenoma Mimicking Tuberculum Sellae Meningioma in a Patient with an Intrasellar Persistent Trigeminal Artery. J Neurol Surg B Skull Base. 2018 Apr; 79(Suppl 3):S285-S286.
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Adult Tethered Cord Syndrome Following Chiari Decompression. World Neurosurg. 2018 Apr; 112:205-208.
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Preclinical investigation of combined gene-mediated cytotoxic immunotherapy and immune checkpoint blockade in glioblastoma. Neuro Oncol. 2018 01 22; 20(2):225-235.
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Modeling tumor immunity of mouse glioblastoma by exhausted CD8+ T cells. Sci Rep. 2018 01 09; 8(1):208.
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Multiplexed Profiling of Single Extracellular Vesicles. ACS Nano. 2018 01 23; 12(1):494-503.
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Oncolytic viruses sensitize human tumor cells for NY-ESO-1 tumor antigen recognition by CD4+ effector T cells. Oncoimmunology. 2018; 7(3):e1407897.
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Anticancer activity of osmium(VI) nitrido complexes in patient-derived glioblastoma initiating cells and in vivo mouse models. Cancer Lett. 2018 03 01; 416:138-148.
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Development of a Function-Blocking Antibody Against Fibulin-3 as a Targeted Reagent for Glioblastoma. Clin Cancer Res. 2018 02 15; 24(4):821-833.
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Immunotherapy for glioblastoma: on the sidelines or in the game? Discov Med. 2017 11; 24(133):201-208.
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Perfluoroarene-Based Peptide Macrocycles to Enhance Penetration Across the Blood-Brain Barrier. J Am Chem Soc. 2017 11 08; 139(44):15628-15631.
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Detection of wild-type EGFR amplification and EGFRvIII mutation in CSF-derived extracellular vesicles of glioblastoma patients. Neuro Oncol. 2017 Oct 19; 19(11):1494-1502.
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Salvage re-irradiation for recurrent high-grade glioma and comparison to bevacizumab alone. J Neurooncol. 2017 Dec; 135(3):581-591.
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Human Cytomegalovirus is Present in Alveolar Soft Part Sarcoma. Appl Immunohistochem Mol Morphol. 2017 Oct; 25(9):615-619.
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The Fc Domain of Immunoglobulin Is Sufficient to Bridge NK Cells with Virally Infected Cells. Immunity. 2017 07 18; 47(1):159-170.e10.
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Blood-brain-barrier spheroids as an in vitro screening platform for brain-penetrating agents. Nat Commun. 2017 06 06; 8:15623.
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MicroRNA-Mediated Dynamic Bidirectional Shift between the Subclasses of Glioblastoma Stem-like Cells. Cell Rep. 2017 06 06; 19(10):2026-2032.
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Oncolytic Viruses in Cancer Treatment: A Review. JAMA Oncol. 2017 Jun 01; 3(6):841-849.
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Dissecting inherent intratumor heterogeneity in patient-derived glioblastoma culture models. Neuro Oncol. 2017 06 01; 19(6):820-832.
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MicroRNA Signatures and Molecular Subtypes of Glioblastoma: The Role of Extracellular Transfer. Stem Cell Reports. 2017 06 06; 8(6):1497-1505.
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Launching Effectiveness Research to Guide Practice in Neurosurgery: A National Institute Neurological Disorders and Stroke Workshop Report. Neurosurgery. 2017 04 01; 80(4):505-514.
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A Phase I Trial of Ad.hIFN-ß Gene Therapy for Glioma. Mol Ther. 2008 Mar; 16(3):618-626.
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Tannous et al. Respond. Mol Ther. 2009 Aug; 17(8):1311-1312.
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Frontal dermoid cyst coexisting with suprasellar craniopharyngioma: a spectrum of ectodermally derived epithelial-lined cystic lesions? Neurosurg Focus. 2016 12; 41(6):E16.
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Glioma and microglia, a double entendre. Nat Immunol. 2016 10 19; 17(11):1240-1242.
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Association between shunt-responsive idiopathic normal pressure hydrocephalus and alcohol. J Neurosurg. 2017 Aug; 127(2):240-248.
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The Long Non-coding RNA HIF1A-AS2 Facilitates the Maintenance of Mesenchymal Glioblastoma Stem-like Cells in Hypoxic Niches. Cell Rep. 2016 06 14; 15(11):2500-9.
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Design of a Microfluidic Chip for Magnetic-Activated Sorting of One-Bead-One-Compound Libraries. ACS Comb Sci. 2016 06 13; 18(6):271-8.
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A combinational therapy of EGFR-CAR NK cells and oncolytic herpes simplex virus 1 for breast cancer brain metastases. Oncotarget. 2016 May 10; 7(19):27764-77.
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Extracellular Vesicles from High-Grade Glioma Exchange Diverse Pro-oncogenic Signals That Maintain Intratumoral Heterogeneity. Cancer Res. 2016 05 15; 76(10):2876-81.
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Extracellular Vesicles and MicroRNAs: Their Role in Tumorigenicity and Therapy for Brain Tumors. Cell Mol Neurobiol. 2016 Apr; 36(3):361-76.
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Therapeutic potential of targeting microRNA-10b in established intracranial glioblastoma: first steps toward the clinic. EMBO Mol Med. 2016 Mar 01; 8(3):268-87.
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BKM-120 (Buparlisib): A Phosphatidyl-Inositol-3 Kinase Inhibitor with Anti-Invasive Properties in Glioblastoma. Sci Rep. 2016 Feb 05; 6:20189.
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Phase II multicenter study of gene-mediated cytotoxic immunotherapy as adjuvant to surgical resection for newly diagnosed malignant glioma. Neuro Oncol. 2016 08; 18(8):1137-45.
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Current State of Immune-Based Therapies for Glioblastoma. Am Soc Clin Oncol Educ Book. 2016; 35:e132-9.
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Experimental therapies: gene therapies and oncolytic viruses. Handb Clin Neurol. 2016; 134:183-97.
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Cancer immunotherapy: A vaccine from plant virus proteins. Nat Nanotechnol. 2016 Mar; 11(3):214-5.
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TGFß Treatment Enhances Glioblastoma Virotherapy by Inhibiting the Innate Immune Response. Cancer Res. 2015 Dec 15; 75(24):5273-82.
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Awake Craniotomy and Intraoperative MRI for Maximal Safe Resection in a Case of an Extensive Left Frontal and Insular Low-grade Glioma: 3-Dimensional Operative Video. Oper Neurosurg (Hagerstown). 2015 Dec 01; 11(4):578.
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Combining HDAC inhibitors with oncolytic virotherapy for cancer therapy. Oncolytic Virother. 2015; 4:183-91.
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Reconstruction of Rare Skull Metastases Using Free Latissimus Dorsi Flap and the Role of Preoperative Embolization in Hypervascular Skull Tumors. J Craniofac Surg. 2015 Nov; 26(8):2289-92.
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Histone deacetylase 6 inhibition enhances oncolytic viral replication in glioma. J Clin Invest. 2015 Nov 02; 125(11):4269-80.
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Awake right hemisphere brain surgery. J Clin Neurosci. 2015 Dec; 22(12):1921-7.
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Oncolytic Virus-Mediated Immunotherapy: A Combinatorial Approach for Cancer Treatment. J Clin Oncol. 2015 Sep 01; 33(25):2812-4.
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In vitro screening of clinical drugs identifies sensitizers of oncolytic viral therapy in glioblastoma stem-like cells. Gene Ther. 2015 Dec; 22(12):947-59.
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Response to energy depletion: miR-451/AMPK loop. Oncotarget. 2015 Jul 20; 6(20):17851-2.
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CAR-Engineered NK Cells Targeting Wild-Type EGFR and EGFRvIII Enhance Killing of Glioblastoma and Patient-Derived Glioblastoma Stem Cells. Sci Rep. 2015 Jul 09; 5:11483.
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Incidence, risk factors, and reasons for hospitalization among glioblastoma patients receiving chemoradiation. J Neurooncol. 2015 Aug; 124(1):137-46.
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One size should not fit all: advancing toward personalized glioblastoma therapy. Discov Med. 2015 Jun; 19(107):471-7.
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Extracranial growth of glioblastoma multiforme. J Clin Neurosci. 2015 Sep; 22(9):1521-3.
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A cross-talk network that facilitates tumor virotherapy. Nat Med. 2015 May; 21(5):426-7.
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Glucose-based regulation of miR-451/AMPK signaling depends on the OCT1 transcription factor. Cell Rep. 2015 May 12; 11(6):902-909.
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Potentiating oncolytic viral therapy through an understanding of the initial immune responses to oncolytic viral infection. Curr Opin Virol. 2015 Aug; 13:25-32.
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Hypofractionated versus standard radiation therapy with or without temozolomide for older glioblastoma patients. Int J Radiat Oncol Biol Phys. 2015 Jun 01; 92(2):384-9.
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Modeling cytomegalovirus infection in mouse tumor models. Front Oncol. 2015; 5:61.
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Clinical implementation of integrated whole-genome copy number and mutation profiling for glioblastoma. Neuro Oncol. 2015 Oct; 17(10):1344-55.
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The Role of Radiation Therapy in Gross Totally Resected Meningiomas. World Neurosurg. 2015 Jul; 84(1):9-11.
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MicroRNA-10b inhibition reduces E2F1-mediated transcription and miR-15/16 activity in glioblastoma. Oncotarget. 2015 Feb 28; 6(6):3770-83.
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Editorial: the management of low-grade glioma in adults. Neurosurg Focus. 2015 Jan; 38(1):E8.
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Introduction: a focus on low-grade glioma. Neurosurg Focus. 2015 Jan; 38(1):E2.
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Superficial greater petrosal neuropathy. Neurol Clin Pract. 2014 Dec; 4(6):505-507.
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Interferon-stimulated gene 15 (ISG15) and ISG15-linked proteins can associate with members of the selective autophagic process, histone deacetylase 6 (HDAC6) and SQSTM1/p62. J Biol Chem. 2015 Jan 16; 290(3):1485-95.
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Belonging to a network--microRNAs, extracellular vesicles, and the glioblastoma microenvironment. Neuro Oncol. 2015 May; 17(5):652-62.
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Predicting outcomes: recursive partitioning analysis (RPA) prognostic algorithm for patients with metastatic sarcoma to the brain. World Neurosurg. 2014 Dec; 82(6):1030-2.
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Use of miRNA response sequences to block off-target replication and increase the safety of an unattenuated, glioblastoma-targeted oncolytic HSV. Mol Ther. 2015 Jan; 23(1):99-107.
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Immunotherapy advances for glioblastoma. Neuro Oncol. 2014 Nov; 16(11):1441-58.
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Skull base chordomas and chondrosarcomas: a population-based analysis. World Neurosurg. 2015 Apr; 83(4):468-70.
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Evolution of malignant glioma treatment: from chemotherapy to vaccines to viruses. Neurosurgery. 2014 Aug; 61 Suppl 1:74-83.
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Annexin A2 regulates angiogenesis and invasion phenotypes of malignant glioma. Neuro Oncol. 2014 Jul; 16 Suppl 3:iii10.
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Cytomegalovirus contributes to glioblastoma in the context of tumor suppressor mutations. Neuro Oncol. 2014 Jul; 16 Suppl 3:iii8.
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Low-grade gliomas and quality of life. World Neurosurg. 2014 Jul-Aug; 82(1-2):e133-4.
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How much is enough? The question of extent of resection in glioblastoma multiforme. World Neurosurg. 2014 Jul-Aug; 82(1-2):e109-10.
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Image-guided maximal resection of intrinsic tumors. World Neurosurg. 2014 Nov; 82(5):604-5.
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Oncolytic viruses targeting tumor stem cells. Cancer Res. 2014 Jul 01; 74(13):3396-8.
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Oncolytic viruses and their application to cancer immunotherapy. Cancer Immunol Res. 2014 Apr; 2(4):295-300.
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Who benefits from surgery for brain metastases? World Neurosurg. 2014 Jul-Aug; 82(1-2):e115-6.
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Phase 1 clinical trial of intratumoral reovirus infusion for the treatment of recurrent malignant gliomas in adults. Mol Ther. 2014 May; 22(5):1056-62.
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No free lunch: secondary neoplasms after stereotactic radiation. World Neurosurg. 2015 Mar; 83(3):330-1.
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Glioma virus therapies between bench and bedside. Neuro Oncol. 2014 Mar; 16(3):334-51.
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Genetic validation of the protein arginine methyltransferase PRMT5 as a candidate therapeutic target in glioblastoma. Cancer Res. 2014 Mar 15; 74(6):1752-65.
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Modification of HSV-1 to an oncolytic virus. Methods Mol Biol. 2014; 1144:117-27.
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Extracellular vesicles modulate the glioblastoma microenvironment via a tumor suppression signaling network directed by miR-1. Cancer Res. 2014 Feb 01; 74(3):738-750.
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Academic productivity in today's training climate: a fellowship's impact. World Neurosurg. 2015 Mar; 83(3):328-9.
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Switching a replication-defective adenoviral vector into a replication-competent, oncolytic adenovirus. J Virol. 2014 Jan; 88(1):345-53.
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Strategies in gene therapy for glioblastoma. Cancers (Basel). 2013 Oct 23; 5(4):1271-305.
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DNA demethylating agents synergize with oncolytic HSV1 against malignant gliomas. Clin Cancer Res. 2013 Nov 01; 19(21):5952-9.
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From localization to pathways: the continuing evolution of diffusion tensor imaging. World Neurosurg. 2014 Jul-Aug; 82(1-2):e47-8.
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Oncolytic virotherapy for gliomas: steps toward the future. CNS Oncol. 2013 Sep; 2(5):389-92.
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Methylation markers of malignant potential in meningiomas. J Neurosurg. 2013 Oct; 119(4):899-906.
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Toxicology and Biodistribution Studies for MGH2.1, an Oncolytic Virus that Expresses Two Prodrug-activating Genes, in Combination with Prodrugs. Mol Ther Nucleic Acids. 2013 Aug 06; 2:e113.
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STAT3 activation promotes oncolytic HSV1 replication in glioma cells. PLoS One. 2013; 8(8):e71932.
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Mutations in glioblastoma oncosuppressive pathways pave the way for oncomodulatory activity of cytomegalovirus. Oncoimmunology. 2013 Sep 01; 2(9):e25620.
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The integrin inhibitor cilengitide enhances the anti-glioma efficacy of vasculostatin-expressing oncolytic virus. Cancer Gene Ther. 2013 Aug; 20(8):437-44.
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Adult cerebellar glioblastomas: a distinct entity or parcel of the whole? World Neurosurg. 2013 Dec; 80(6):e181-3.
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MicroRNA-128 coordinately targets Polycomb Repressor Complexes in glioma stem cells. Neuro Oncol. 2013 Sep; 15(9):1212-24.
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Cytomegalovirus contributes to glioblastoma in the context of tumor suppressor mutations. Cancer Res. 2013 Jun 01; 73(11):3441-50.
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An update on vaccine therapy and other immunotherapeutic approaches for glioblastoma. Expert Rev Vaccines. 2013 Jun; 12(6):597-615.
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Gene expression profiling of the anti-glioma effect of Cilengitide. Springerplus. 2013 Dec; 2(1):160.
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Editorial: Glioblastoma multiforme and laser interstitial thermal therapy. J Neurosurg. 2013 Jun; 118(6):1199-200; discussion 1200-1.
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Uncovering a novel mechanism whereby NK cells interfere with glioblastoma virotherapy. Oncoimmunology. 2013 Apr 01; 2(4):e23658.
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"Infectious" optimism for treatment of hepatocellular carcinoma. Mol Ther. 2013 Apr; 21(4):722-4.
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Stereotactic radiosurgery and atypical meningiomas. J Neurosurg. 2013 Aug; 119(2):472-4.
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Anti-angiogenic gene therapy in the treatment of malignant gliomas. Neurosci Lett. 2012 Oct 11; 527(2):62-70.
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Understanding glioma invasion: a necessity for effective therapy. World Neurosurg. 2013 Sep-Oct; 80(3-4):281-3.
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Cellular automaton of idealized brain tumor growth dynamics. Biosystems. 2000 Feb; 55(1-3):119-27.
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Oncolytic viruses as novel anticancer agents: turning one scourge against another. Expert Opin Investig Drugs. 2000 Feb; 9(2):311-27.
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Solitary sciatic nerve lymphoma as an initial manifestation of diffuse neurolymphomatosis. Case report and review of the literature. J Neurosurg. 2000 Jan; 92(1):165-9.
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Single-step conversion of cells to retrovirus vector producers with herpes simplex virus-Epstein-Barr virus hybrid amplicons. J Virol. 1999 Dec; 73(12):10426-39.
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B-myb promoter retargeting of herpes simplex virus gamma34.5 gene-mediated virulence toward tumor and cycling cells. J Virol. 1999 Sep; 73(9):7556-64.
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Multimodal cancer treatment mediated by a replicating oncolytic virus that delivers the oxazaphosphorine/rat cytochrome P450 2B1 and ganciclovir/herpes simplex virus thymidine kinase gene therapies. Cancer Res. 1999 Aug 15; 59(16):3861-5.
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Oncolytic virus therapy of multiple tumors in the brain requires suppression of innate and elicited antiviral responses. Nat Med. 1999 Aug; 5(8):881-7.
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Inhibition of NF2-negative and NF2-positive primary human meningioma cell proliferation by overexpression of merlin due to vector-mediated gene transfer. J Neurosurg. 1999 Jul; 91(1):85-92.
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Cerebrovascular Biology and the various neural barriers: challenges and future directions. Neurosurgery. 1999 Mar; 44(3):604-8; discussion 608-9.
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Intraarterial delivery of adenovirus vectors and liposome-DNA complexes to experimental brain neoplasms. Hum Gene Ther. 1999 Jan 20; 10(2):311-8.
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Neurogenetic surgery: current limitations and the promise of gene- and virus-based therapies. Clin Neurosurg. 1999; 45:226-46.
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A review of gene therapy for the treatment of central nervous system tumors. Crit Rev Oncog. 1999; 10(4):261-74.
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Intra-arterial virus and nonvirus vector-mediated gene transfer to experimental rat brain tumors. Front Radiat Ther Oncol. 1999; 33:227-40.
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Selective delivery of herpes virus vectors to experimental brain tumors using RMP-7. Cancer Gene Ther. 1999 Jan-Feb; 6(1):14-20.
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Influence of p53 on herpes simplex virus type 1 vectors for cancer gene therapy. J Gastrointest Surg. 1999 Jan-Feb; 3(1):34-48.
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Herpes simplex virus type 1 DNA amplified as bacterial artificial chromosome in Escherichia coli: rescue of replication-competent virus progeny and packaging of amplicon vectors. Hum Gene Ther. 1998 Dec 10; 9(18):2787-94.
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Cancer gene therapy using a replication-competent herpes simplex virus type 1 vector. Ann Surg. 1998 Sep; 228(3):366-74.
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Gene therapy for tumors of the central nervous system. Surg Oncol Clin N Am. 1998 Jul; 7(3):589-602.
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New prodrug activation gene therapy for cancer using cytochrome P450 4B1 and 2-aminoanthracene/4-ipomeanol. Hum Gene Ther. 1998 Jun 10; 9(9):1261-73.
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Pre-existing herpes simplex virus 1 (HSV-1) immunity decreases, but does not abolish, gene transfer to experimental brain tumors by a HSV-1 vector. Gene Ther. 1998 Jun; 5(6):809-19.
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Petroclival meningioma presenting with pathological laughter. Neurology. 1998 Jun; 50(6):1918-9.
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Long-term survival in a rodent brain tumor model by bradykinin-enhanced intra-arterial delivery of a therapeutic herpes simplex virus vector. Cancer Gene Ther. 1998 May-Jun; 5(3):158-62.
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An oncolytic viral mutant that delivers the CYP2B1 transgene and augments cyclophosphamide chemotherapy. Nat Biotechnol. 1998 May; 16(5):444-8.
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Measuring transferrin receptor gene expression by NMR imaging. Biochim Biophys Acta. 1998 Apr 24; 1402(3):239-49.
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Effects on brain tumor cell proliferation by an adenovirus vector that bears the interleukin-4 gene. J Neurovirol. 1998 Apr; 4(2):237-41.
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Synergistic anticancer effects of ganciclovir/thymidine kinase and 5-fluorocytosine/cytosine deaminase gene therapies. J Natl Cancer Inst. 1998 Mar 04; 90(5):370-80.
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Co-expression of Fas and Fas ligand in malignant glial tumors and cell lines. Acta Neuropathol. 1998 Mar; 95(3):287-90.
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Marker gene transfer and oncolysis of human Y79 retinoblastoma cells mediated by herpes simplex virus mutants. Ophthalmic Res. 1998; 30(1):30-6.
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A chimeric fusion protein of cytochrome CYP4B1 and green fluorescent protein for detection of pro-drug activating gene delivery and for gene therapy in malignant glioma. Adv Exp Med Biol. 1998; 451:393-403.
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Therapeutic efficiency and safety of a second-generation replication-conditional HSV1 vector for brain tumor gene therapy. Hum Gene Ther. 1997 Nov 20; 8(17):2057-68.
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Regression of experimental brain tumors with 6-thioxanthine and Escherichia coli gpt gene therapy. Hum Gene Ther. 1997 Nov 20; 8(17):2043-55.
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The effect of ganciclovir on herpes simplex virus-mediated oncolysis. J Surg Res. 1997 May; 69(2):413-7.
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Long-term survival in a rodent model of disseminated brain tumors by combined intrathecal delivery of herpes vectors and ganciclovir treatment. Hum Gene Ther. 1996 Oct 20; 7(16):1989-94.
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A novel 'piggyback' packaging system for herpes simplex virus amplicon vectors. Hum Gene Ther. 1996 Oct 20; 7(16):2003-13.
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Enhancement of gene therapy specificity for diffuse colon carcinoma liver metastases with recombinant herpes simplex virus. Ann Surg. 1996 Sep; 224(3):323-9; discussion 329-30.
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The subtemporal-transpetrous approach for excision of petroclival tumors. Am J Otol. 1996 Sep; 17(5):773-9.
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Escherichia coli gpt gene sensitizes rat glioma cells to killing by 6-thioxanthine or 6-thioguanine. Cancer Gene Ther. 1996 May-Jun; 3(3):155-62.
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Herpes vector-mediated delivery of marker genes to disseminated central nervous system tumors. Hum Gene Ther. 1996 Feb 10; 7(3):291-300.
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Comparison of intracerebral inoculation and osmotic blood-brain barrier disruption for delivery of adenovirus, herpesvirus, and iron oxide particles to normal rat brain. Am J Pathol. 1995 Dec; 147(6):1840-51.
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Selective uptake of viral and monocrystalline particles delivered intra-arterially to experimental brain neoplasms. Hum Gene Ther. 1995 Dec; 6(12):1543-52.
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Transgene inheritance and retroviral infection contribute to the efficiency of gene expression in solid tumors inoculated with retroviral vector producer cells. Gene Ther. 1995 Oct; 2(8):531-8.
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Gene therapy for brain tumors. Brain Pathol. 1995 Oct; 5(4):345-81.
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Diffusible cytotoxic metabolites contribute to the in vitro bystander effect associated with the cyclophosphamide/cytochrome P450 2B1 cancer gene therapy paradigm. Clin Cancer Res. 1995 Oct; 1(10):1171-7.
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Enhancement of interleukin-4-mediated tumor regression in athymic mice by in situ retroviral gene transfer. Hum Gene Ther. 1995 Apr; 6(4):437-43.
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Brain tumor gene therapy in mice with a novel "suicide" gene: the cyclophosphamide-activating CYP2B1 gene. Clin Neurosurg. 1995; 42:370-82.
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[Gene therapy for brain tumors: gene therapy for malignant brain tumors using prodrug-sensitivity genes (series 4)]. No Shinkei Geka. 1994 Dec; 22(12):1099-110.
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Long-term survival of rats harboring brain neoplasms treated with ganciclovir and a herpes simplex virus vector that retains an intact thymidine kinase gene. Cancer Res. 1994 Nov 15; 54(22):5745-51.
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Deep sylvian fissure meningioma without dural attachment in an adult: case report. Neurosurgery. 1994 Nov; 35(5):944-6; discussion 946.
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Antitumor activity and reporter gene transfer into rat brain neoplasms inoculated with herpes simplex virus vectors defective in thymidine kinase or ribonucleotide reductase. Gene Ther. 1994 Sep; 1(5):323-31.
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Experimental tumor therapy in mice using the cyclophosphamide-activating cytochrome P450 2B1 gene. Hum Gene Ther. 1994 Aug; 5(8):969-78.
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Nerve growth factor protects against herpes simplex virus type 1 neurotoxicity in the rat striatum. Neuroreport. 1994 Apr 14; 5(8):993-6.
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Gene transfer into experimental brain tumors mediated by adenovirus, herpes simplex virus, and retrovirus vectors. Hum Gene Ther. 1994 Feb; 5(2):183-91.
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Treatment of glioma by engineered interleukin 4-secreting cells. Cancer Res. 1993 Jul 01; 53(13):3125-8.
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Growth of human acoustic neuromas, neurofibromas and schwannomas in the subrenal capsule and sciatic nerve of the nude mouse. J Neurooncol. 1992 Oct; 14(2):101-12.
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Isolation and characterization of cDNA clones to mouse macrophage and human endothelial cell tissue transglutaminases. J Biol Chem. 1991 Jan 05; 266(1):478-83.
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Inhibition of growth and angiogenesis of human neurofibrosarcoma by heparin and hydrocortisone. J Neurosurg. 1990 Sep; 73(3):429-35.
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Transfer and expression of the lacZ gene in rat brain neurons mediated by herpes simplex virus mutants. New Biol. 1990 Aug; 2(8):739-46.
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Growth of human schwannomas in the subrenal capsule of the nude mouse. Neurosurgery. 1990 Apr; 26(4):598-605.
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Stereotactic radiofrequency thermal cingulotomy for obsessive compulsive disorder. J Neuropsychiatry Clin Neurosci. 1990; 2(3):331-6.
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Regulation of tissue transglutaminase gene expression as a molecular model for retinoid effects on proliferation and differentiation. J Cell Biochem. 1989 Mar; 39(3):293-304.
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Retinoids as generalized regulators of cellular growth and differentiation. Am J Med Sci. 1988 Sep; 296(3):164-70.
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The molecular basis of retinoic acid action. Transcriptional regulation of tissue transglutaminase gene expression in macrophages. J Biol Chem. 1988 Aug 15; 263(23):11584-9.
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Retinoid--regulated expression of tissue transglutaminase in normal and leukemic myeloid cells. Adv Exp Med Biol. 1988; 231:63-71.
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Transglutaminases and their regulation: implications for polyamine metabolism. Adv Exp Med Biol. 1988; 250:391-401.
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