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Recent oncolytic virotherapy clinical trials outline a roadmap for the treatment of high-grade glioma. Neurooncol Adv. 2023 Jan-Dec; 5(1):vdad081.
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Clinical Importance of the lncRNA NEAT1 in Cancer Patients Treated with Immune Checkpoint Inhibitors. Clin Cancer Res. 2023 06 13; 29(12):2226-2238.
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Uncovering transcriptomic landscape alterations of CAN-2409 in in vitro and in vivo glioma models. Front Med (Lausanne). 2023; 10:1140352.
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PPRX-1701, a nanoparticle formulation of 6'-bromoindirubin acetoxime, improves delivery and shows efficacy in preclinical GBM models. Cell Rep Med. 2023 05 16; 4(5):101019.
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The Role of Long Noncoding Ribonucleic Acids in Glioblastoma: What the Neurosurgeon Should Know. Neurosurgery. 2023 06 01; 92(6):1104-1111.
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Reduced time to imaging, length of stay, and hospital charges following implementation of a novel postoperative pathway for craniotomy. J Neurosurg. 2023 Jan 06; 1-12.
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Cerebellar High-Grade Glioma: A Translationally Oriented Review of the Literature. Cancers (Basel). 2022 Dec 28; 15(1).
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Dual Immunostimulatory Pathway Agonism through a Synthetic Nanocarrier Triggers Robust Anti-Tumor Immunity in Murine Glioblastoma. Adv Mater. 2023 Feb; 35(7):e2208782.
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The emerging field of oncolytic virus-based cancer immunotherapy. Trends Cancer. 2023 02; 9(2):122-139.
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Specific targeting of glioblastoma with an oncolytic virus expressing a cetuximab-CCL5 fusion protein via innate and adaptive immunity. Nat Cancer. 2022 11; 3(11):1318-1335.
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Variants of the adeno-associated virus serotype 9 with enhanced penetration of the blood-brain barrier in rodents and primates. Nat Biomed Eng. 2022 11; 6(11):1257-1271.
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Treat and repeat: oncolytic virus therapy for brain cancer. Nat Med. 2022 08; 28(8):1540-1542.
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Perturbing DDR signaling enhances cytotoxic effects of local oncolytic virotherapy and modulates the immune environment in glioma. Mol Ther Oncolytics. 2022 Sep 15; 26:275-288.
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Carole A. Miller, MD: Matriarch of the Ohio State University's Department of Neurosurgery. World Neurosurg. 2022 Oct; 166:33-38.
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STING activation promotes robust immune response and NK cell-mediated tumor regression in glioblastoma models. Proc Natl Acad Sci U S A. 2022 07 12; 119(28):e2111003119.
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Clinical utility of targeted next-generation sequencing assay in IDH-wildtype glioblastoma for therapy decision-making. Neuro Oncol. 2022 07 01; 24(7):1140-1149.
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The current state of glioma data registries. Neurooncol Adv. 2022 Jan-Dec; 4(1):vdac099.
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Combined immunotherapy with controlled interleukin-12 gene therapy and immune checkpoint blockade in recurrent glioblastoma: An open-label, multi-institutional phase I trial. Neuro Oncol. 2022 06 01; 24(6):951-963.
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Target receptor identification and subsequent treatment of resected brain tumors with encapsulated and engineered allogeneic stem cells. Nat Commun. 2022 05 19; 13(1):2810.
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Agent-based computational modeling of glioblastoma predicts that stromal density is central to oncolytic virus efficacy. iScience. 2022 Jun 17; 25(6):104395.
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NOTCH-Induced MDSC Recruitment after oHSV Virotherapy in CNS Cancer Models Modulates Antitumor Immunotherapy. Clin Cancer Res. 2022 04 01; 28(7):1460-1473.
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Advances in local therapy for glioblastoma - taking the fight to the tumour. Nat Rev Neurol. 2022 04; 18(4):221-236.
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Tumor-Associated Macrophages/Microglia in Glioblastoma Oncolytic Virotherapy: A Double-Edged Sword. Int J Mol Sci. 2022 Feb 04; 23(3).
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Immune Checkpoint Inhibition in GBM Primed with Radiation by Engineered Extracellular Vesicles. ACS Nano. 2022 02 22; 16(2):1940-1953.
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Activity of PD-1 blockade with nivolumab among patients with recurrent atypical/anaplastic meningioma: phase II trial results. Neuro Oncol. 2022 01 05; 24(1):101-113.
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Autoimmune Cytopenias and Dysregulated Immunophenotype Act as Warning Signs of Inborn Errors of Immunity: Results From a Prospective Study. Front Immunol. 2021; 12:790455.
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Systemic high-dose dexamethasone treatment may modulate the efficacy of intratumoral viral oncolytic immunotherapy in glioblastoma models. J Immunother Cancer. 2022 01; 10(1).
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Quantitative imaging of apoptosis following oncolytic virotherapy by magnetic resonance fingerprinting aided by deep learning. Nat Biomed Eng. 2022 05; 6(5):648-657.
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Glial and myeloid heterogeneity in the brain tumour microenvironment. Nat Rev Cancer. 2021 12; 21(12):786-802.
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The Evolving Role of Neurosurgical Intervention for Central Nervous System Tumors. Hematol Oncol Clin North Am. 2022 02; 36(1):63-75.
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Treatment of glioblastoma with current oHSV variants reveals differences in efficacy and immune cell recruitment. Mol Ther Oncolytics. 2021 Sep 24; 22:444-453.
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Evolution of the Neurosurgeon's Role in Clinical Trials for Glioblastoma: A Systematic Overview of the Clinicaltrials.Gov Database. Neurosurgery. 2021 07 15; 89(2):196-203.
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The Current Landscape of Oncolytic Herpes Simplex Viruses as Novel Therapies for Brain Malignancies. Viruses. 2021 06 17; 13(6).
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Neurosurgery Research and Education Foundation funding conversion to National Institutes of Health funding. J Neurosurg. 2022 Jan 01; 136(1):287-294.
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Cytomegalovirus infection of glioblastoma cells leads to NF-?B dependent upregulation of the c-MET oncogenic tyrosine kinase. Cancer Lett. 2021 08 10; 513:26-35.
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Role of surgery for glioblastoma: response to letters from Dr. Gerritsen and his colleagues and Dr. Vargas Lopez. Neuro Oncol. 2021 03 25; 23(3):506-507.
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Unique challenges for glioblastoma immunotherapy-discussions across neuro-oncology and non-neuro-oncology experts in cancer immunology. Meeting Report from the 2019 SNO Immuno-Oncology Think Tank. Neuro Oncol. 2021 03 25; 23(3):356-375.
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Oncolytic Virus Therapy Alters the Secretome of Targeted Glioblastoma Cells. Cancers (Basel). 2021 Mar 14; 13(6).
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Biographies of international women leaders in neurosurgery. Neurosurg Focus. 2021 03; 50(3):E19.
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Inhibitory CD161 receptor identified in glioma-infiltrating T cells by single-cell analysis. Cell. 2021 03 04; 184(5):1281-1298.e26.
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Therapeutic cancer vaccines for pediatric malignancies: advances, challenges, and emerging technologies. Neurooncol Adv. 2021 Jan-Dec; 3(1):vdab027.
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Targeting glioblastoma using a novel peptide specific to a deglycosylated isoform of brevican. Adv Ther (Weinh). 2021 Apr; 4(4).
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The nuclear DICER-circular RNA complex drives the deregulation of the glioblastoma cell microRNAome. Sci Adv. 2020 12; 6(51).
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HSV-1 Oncolytic Viruses from Bench to Bedside: An Overview of Current Clinical Trials. Cancers (Basel). 2020 Nov 26; 12(12).
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Redesigned reporter gene for improved proton exchange-based molecular MRI contrast. Sci Rep. 2020 11 26; 10(1):20664.
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Concurrent Dexamethasone Limits the Clinical Benefit of Immune Checkpoint Blockade in Glioblastoma. Clin Cancer Res. 2021 01 01; 27(1):276-287.
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Oncolytic HSV Vectors and Anti-Tumor Immunity. Curr Issues Mol Biol. 2021; 41:381-468.
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Glioblastoma in adults: a Society for Neuro-Oncology (SNO) and European Society of Neuro-Oncology (EANO) consensus review on current management and future directions. Neuro Oncol. 2020 08 17; 22(8):1073-1113.
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Letter: Adaptation Under Fire: Two Harvard Neurosurgical Services During the COVID-19 Pandemic. Neurosurgery. 2020 08 01; 87(2):E173-E177.
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National Institute of Neurological Disorders and Stroke: current funding status, opportunities, challenges, emerging scientific advances, and recommendations for neurosurgery. J Neurosurg. 2020 Jul 03; 1-6.
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A Platinum(IV) Prodrug-Perfluoroaryl Macrocyclic Peptide Conjugate Enhances Platinum Uptake in the Brain. J Med Chem. 2020 07 09; 63(13):6741-6747.
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Extracellular Vesicles Induce Mesenchymal Transition and Therapeutic Resistance in Glioblastomas through NF-?B/STAT3 Signaling. Adv Biosyst. 2020 12; 4(12):e1900312.
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Tumor Interferon Signaling Is Regulated by a lncRNA INCR1 Transcribed from the PD-L1 Locus. Mol Cell. 2020 06 18; 78(6):1207-1223.e8.
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Hypoxic Roadmap of Glioblastoma-Learning about Directions and Distances in the Brain Tumor Environment. Cancers (Basel). 2020 May 13; 12(5).
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Immune Escape Mediated by Exosomal PD-L1 in Cancer. Adv Biosyst. 2020 12; 4(12):e2000017.
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Editorial. COVID-19 and academic neurosurgery. J Neurosurg. 2020 Apr 17; 1-2.
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Mechanisms and therapeutic implications of hypermutation in gliomas. Nature. 2020 04; 580(7804):517-523.
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Cytomegalovirus Encephalopathy during Brain Tumor Irradiation. Clin Cancer Res. 2020 07 01; 26(13):3077-3078.
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KLF4K409Q-mutated meningiomas show enhanced hypoxia signaling and respond to mTORC1 inhibitor treatment. Acta Neuropathol Commun. 2020 04 03; 8(1):41.
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Preclinical Toxicology of rQNestin34.5v.2: An Oncolytic Herpes Virus with Transcriptional Regulation of the ICP34.5 Neurovirulence Gene. Mol Ther Methods Clin Dev. 2020 Jun 12; 17:871-893.
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Glioblastoma infiltration of both tumor- and virus-antigen specific cytotoxic T cells correlates with experimental virotherapy responses. Sci Rep. 2020 03 20; 10(1):5095.
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FASN Is a Biomarker Enriched in Malignant Glioma-Derived Extracellular Vesicles. Int J Mol Sci. 2020 Mar 12; 21(6).
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Targeting glioma-initiating cells via the tyrosine metabolic pathway. J Neurosurg. 2020 Feb 14; 134(3):721-732.
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Correction: Arming an Oncolytic Herpes Simplex Virus Type 1 with a Single-chain Fragment Variable Antibody against PD-1 for Experimental Glioblastoma Therapy. Clin Cancer Res. 2020 Feb 01; 26(3):758.
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GBM-Targeted oHSV Armed with Matrix Metalloproteinase 9 Enhances Anti-tumor Activity and Animal Survival. Mol Ther Oncolytics. 2019 Dec 20; 15:214-222.
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Letter: When Less is More: Dexamethasone Dosing for Brain Tumors. Neurosurgery. 2019 09 01; 85(3):E607-E608.
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Regulatable interleukin-12 gene therapy in patients with recurrent high-grade glioma: Results of a phase 1 trial. Sci Transl Med. 2019 08 14; 11(505).
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Characterization of single microvesicles in plasma from glioblastoma patients. Neuro Oncol. 2019 05 06; 21(5):606-615.
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Proteomic Analysis Implicates Vimentin in Glioblastoma Cell Migration. Cancers (Basel). 2019 Apr 03; 11(4).
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Radiation-Induced Targeted Nanoparticle-Based Gene Delivery for Brain Tumor Therapy. ACS Nano. 2019 04 23; 13(4):4028-4040.
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Imaging flow cytometry facilitates multiparametric characterization of extracellular vesicles in malignant brain tumours. J Extracell Vesicles. 2019; 8(1):1588555.
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Frameless Stereotactic Navigation during Insular Glioma Resection using Fusion of Three-Dimensional Rotational Angiography and Magnetic Resonance Imaging. World Neurosurg. 2019 Jun; 126:322-330.
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Cytomegalovirus promotes murine glioblastoma growth via pericyte recruitment and angiogenesis. J Clin Invest. 2019 03 11; 129(4):1671-1683.
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Molecular responses to immune checkpoint blockade in glioblastoma. Nat Med. 2019 03; 25(3):359-361.
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Pneumatosis Intestinalis After Molecular-Targeted Therapy. World Neurosurg. 2019 05; 125:312-315.
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The functional synergism of microRNA clustering provides therapeutically relevant epigenetic interference in glioblastoma. Nat Commun. 2019 01 25; 10(1):442.
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Amendments: Publisher Correction: An oncolytic herpesvirus expressing E-cadherin improves survival in mouse models of glioblastoma. Nat Biotechnol. 2019 01 03; 37(1):102.
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Viral and other therapies for recurrent glioblastoma: is a 24-month durable response unusual? Neuro Oncol. 2019 01 01; 21(1):14-25.
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Neoantigen vaccine generates intratumoral T cell responses in phase Ib glioblastoma trial. Nature. 2019 01; 565(7738):234-239.
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An oncolytic herpesvirus expressing E-cadherin improves survival in mouse models of glioblastoma. Nat Biotechnol. 2018 Nov 26.
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Viruses in cancer therapy - from benchwarmers to quarterbacks. Nat Rev Clin Oncol. 2018 11; 15(11):657-658.
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The multiple protective roles and molecular mechanisms of melatonin and its precursor N-acetylserotonin in targeting brain injury and liver damage and in maintaining bone health. Free Radic Biol Med. 2019 01; 130:215-233.
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Arming an Oncolytic Herpes Simplex Virus Type 1 with a Single-chain Fragment Variable Antibody against PD-1 for Experimental Glioblastoma Therapy. Clin Cancer Res. 2019 01 01; 25(1):290-299.
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A PDGFRa-driven mouse model of glioblastoma reveals a stathmin1-mediated mechanism of sensitivity to vinblastine. Nat Commun. 2018 08 06; 9(1):3116.
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Immunotherapy for glioblastoma: going viral. Nat Med. 2018 08; 24(8):1094-1096.
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Immune evasion mediated by PD-L1 on glioblastoma-derived extracellular vesicles. Sci Adv. 2018 03; 4(3):eaar2766.
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Toxicity and Efficacy of a Novel GADD34-expressing Oncolytic HSV-1 for the Treatment of Experimental Glioblastoma. Clin Cancer Res. 2018 06 01; 24(11):2574-2584.
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Endoscopic Endonasal Resection of a Suprasellar Pituitary Adenoma Mimicking Tuberculum Sellae Meningioma in a Patient with an Intrasellar Persistent Trigeminal Artery. J Neurol Surg B Skull Base. 2018 Apr; 79(Suppl 3):S285-S286.
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Adult Tethered Cord Syndrome Following Chiari Decompression. World Neurosurg. 2018 Apr; 112:205-208.
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Preclinical investigation of combined gene-mediated cytotoxic immunotherapy and immune checkpoint blockade in glioblastoma. Neuro Oncol. 2018 01 22; 20(2):225-235.
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Modeling tumor immunity of mouse glioblastoma by exhausted CD8+ T cells. Sci Rep. 2018 01 09; 8(1):208.
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Multiplexed Profiling of Single Extracellular Vesicles. ACS Nano. 2018 01 23; 12(1):494-503.
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Oncolytic viruses sensitize human tumor cells for NY-ESO-1 tumor antigen recognition by CD4+ effector T cells. Oncoimmunology. 2018; 7(3):e1407897.
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Anticancer activity of osmium(VI) nitrido complexes in patient-derived glioblastoma initiating cells and in vivo mouse models. Cancer Lett. 2018 03 01; 416:138-148.
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Development of a Function-Blocking Antibody Against Fibulin-3 as a Targeted Reagent for Glioblastoma. Clin Cancer Res. 2018 02 15; 24(4):821-833.
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Immunotherapy for glioblastoma: on the sidelines or in the game? Discov Med. 2017 11; 24(133):201-208.
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Perfluoroarene-Based Peptide Macrocycles to Enhance Penetration Across the Blood-Brain Barrier. J Am Chem Soc. 2017 11 08; 139(44):15628-15631.
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Detection of wild-type EGFR amplification and EGFRvIII mutation in CSF-derived extracellular vesicles of glioblastoma patients. Neuro Oncol. 2017 Oct 19; 19(11):1494-1502.
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Salvage re-irradiation for recurrent high-grade glioma and comparison to bevacizumab alone. J Neurooncol. 2017 Dec; 135(3):581-591.
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Human Cytomegalovirus is Present in Alveolar Soft Part Sarcoma. Appl Immunohistochem Mol Morphol. 2017 Oct; 25(9):615-619.
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The Fc Domain of Immunoglobulin Is Sufficient to Bridge NK Cells with Virally Infected Cells. Immunity. 2017 07 18; 47(1):159-170.e10.
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Blood-brain-barrier spheroids as an in vitro screening platform for brain-penetrating agents. Nat Commun. 2017 06 06; 8:15623.
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MicroRNA-Mediated Dynamic Bidirectional Shift between the Subclasses of Glioblastoma Stem-like Cells. Cell Rep. 2017 06 06; 19(10):2026-2032.
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Oncolytic Viruses in Cancer Treatment: A Review. JAMA Oncol. 2017 Jun 01; 3(6):841-849.
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Dissecting inherent intratumor heterogeneity in patient-derived glioblastoma culture models. Neuro Oncol. 2017 06 01; 19(6):820-832.
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MicroRNA Signatures and Molecular Subtypes of Glioblastoma: The Role of Extracellular Transfer. Stem Cell Reports. 2017 06 06; 8(6):1497-1505.
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Launching Effectiveness Research to Guide Practice in Neurosurgery: A National Institute Neurological Disorders and Stroke Workshop Report. Neurosurgery. 2017 04 01; 80(4):505-514.
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A Phase I Trial of Ad.hIFN-ß Gene Therapy for Glioma. Mol Ther. 2008 Mar; 16(3):618-626.
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Tannous et al. Respond. Mol Ther. 2009 Aug; 17(8):1311-1312.
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Frontal dermoid cyst coexisting with suprasellar craniopharyngioma: a spectrum of ectodermally derived epithelial-lined cystic lesions? Neurosurg Focus. 2016 12; 41(6):E16.
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Glioma and microglia, a double entendre. Nat Immunol. 2016 10 19; 17(11):1240-1242.
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Association between shunt-responsive idiopathic normal pressure hydrocephalus and alcohol. J Neurosurg. 2017 Aug; 127(2):240-248.
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The Long Non-coding RNA HIF1A-AS2 Facilitates the Maintenance of Mesenchymal Glioblastoma Stem-like Cells in Hypoxic Niches. Cell Rep. 2016 06 14; 15(11):2500-9.
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Design of a Microfluidic Chip for Magnetic-Activated Sorting of One-Bead-One-Compound Libraries. ACS Comb Sci. 2016 06 13; 18(6):271-8.
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A combinational therapy of EGFR-CAR NK cells and oncolytic herpes simplex virus 1 for breast cancer brain metastases. Oncotarget. 2016 May 10; 7(19):27764-77.
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Extracellular Vesicles from High-Grade Glioma Exchange Diverse Pro-oncogenic Signals That Maintain Intratumoral Heterogeneity. Cancer Res. 2016 05 15; 76(10):2876-81.
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Extracellular Vesicles and MicroRNAs: Their Role in Tumorigenicity and Therapy for Brain Tumors. Cell Mol Neurobiol. 2016 Apr; 36(3):361-76.
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Therapeutic potential of targeting microRNA-10b in established intracranial glioblastoma: first steps toward the clinic. EMBO Mol Med. 2016 Mar 01; 8(3):268-87.
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BKM-120 (Buparlisib): A Phosphatidyl-Inositol-3 Kinase Inhibitor with Anti-Invasive Properties in Glioblastoma. Sci Rep. 2016 Feb 05; 6:20189.
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Phase II multicenter study of gene-mediated cytotoxic immunotherapy as adjuvant to surgical resection for newly diagnosed malignant glioma. Neuro Oncol. 2016 08; 18(8):1137-45.
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Current State of Immune-Based Therapies for Glioblastoma. Am Soc Clin Oncol Educ Book. 2016; 35:e132-9.
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Experimental therapies: gene therapies and oncolytic viruses. Handb Clin Neurol. 2016; 134:183-97.
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Cancer immunotherapy: A vaccine from plant virus proteins. Nat Nanotechnol. 2016 Mar; 11(3):214-5.
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TGFß Treatment Enhances Glioblastoma Virotherapy by Inhibiting the Innate Immune Response. Cancer Res. 2015 Dec 15; 75(24):5273-82.
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Awake Craniotomy and Intraoperative MRI for Maximal Safe Resection in a Case of an Extensive Left Frontal and Insular Low-grade Glioma: 3-Dimensional Operative Video. Oper Neurosurg (Hagerstown). 2015 Dec 01; 11(4):578.
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Combining HDAC inhibitors with oncolytic virotherapy for cancer therapy. Oncolytic Virother. 2015; 4:183-91.
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Reconstruction of Rare Skull Metastases Using Free Latissimus Dorsi Flap and the Role of Preoperative Embolization in Hypervascular Skull Tumors. J Craniofac Surg. 2015 Nov; 26(8):2289-92.
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Histone deacetylase 6 inhibition enhances oncolytic viral replication in glioma. J Clin Invest. 2015 Nov 02; 125(11):4269-80.
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Awake right hemisphere brain surgery. J Clin Neurosci. 2015 Dec; 22(12):1921-7.
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Oncolytic Virus-Mediated Immunotherapy: A Combinatorial Approach for Cancer Treatment. J Clin Oncol. 2015 Sep 01; 33(25):2812-4.
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In vitro screening of clinical drugs identifies sensitizers of oncolytic viral therapy in glioblastoma stem-like cells. Gene Ther. 2015 Dec; 22(12):947-59.
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Response to energy depletion: miR-451/AMPK loop. Oncotarget. 2015 Jul 20; 6(20):17851-2.
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CAR-Engineered NK Cells Targeting Wild-Type EGFR and EGFRvIII Enhance Killing of Glioblastoma and Patient-Derived Glioblastoma Stem Cells. Sci Rep. 2015 Jul 09; 5:11483.
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Incidence, risk factors, and reasons for hospitalization among glioblastoma patients receiving chemoradiation. J Neurooncol. 2015 Aug; 124(1):137-46.
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One size should not fit all: advancing toward personalized glioblastoma therapy. Discov Med. 2015 Jun; 19(107):471-7.
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Extracranial growth of glioblastoma multiforme. J Clin Neurosci. 2015 Sep; 22(9):1521-3.
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A cross-talk network that facilitates tumor virotherapy. Nat Med. 2015 May; 21(5):426-7.
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Glucose-based regulation of miR-451/AMPK signaling depends on the OCT1 transcription factor. Cell Rep. 2015 May 12; 11(6):902-909.
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Potentiating oncolytic viral therapy through an understanding of the initial immune responses to oncolytic viral infection. Curr Opin Virol. 2015 Aug; 13:25-32.
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Hypofractionated versus standard radiation therapy with or without temozolomide for older glioblastoma patients. Int J Radiat Oncol Biol Phys. 2015 Jun 01; 92(2):384-9.
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Modeling cytomegalovirus infection in mouse tumor models. Front Oncol. 2015; 5:61.
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Clinical implementation of integrated whole-genome copy number and mutation profiling for glioblastoma. Neuro Oncol. 2015 Oct; 17(10):1344-55.
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The Role of Radiation Therapy in Gross Totally Resected Meningiomas. World Neurosurg. 2015 Jul; 84(1):9-11.
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MicroRNA-10b inhibition reduces E2F1-mediated transcription and miR-15/16 activity in glioblastoma. Oncotarget. 2015 Feb 28; 6(6):3770-83.
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Editorial: the management of low-grade glioma in adults. Neurosurg Focus. 2015 Jan; 38(1):E8.
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Introduction: a focus on low-grade glioma. Neurosurg Focus. 2015 Jan; 38(1):E2.
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Superficial greater petrosal neuropathy. Neurol Clin Pract. 2014 Dec; 4(6):505-507.
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Interferon-stimulated gene 15 (ISG15) and ISG15-linked proteins can associate with members of the selective autophagic process, histone deacetylase 6 (HDAC6) and SQSTM1/p62. J Biol Chem. 2015 Jan 16; 290(3):1485-95.
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Belonging to a network--microRNAs, extracellular vesicles, and the glioblastoma microenvironment. Neuro Oncol. 2015 May; 17(5):652-62.
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Predicting outcomes: recursive partitioning analysis (RPA) prognostic algorithm for patients with metastatic sarcoma to the brain. World Neurosurg. 2014 Dec; 82(6):1030-2.
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Use of miRNA response sequences to block off-target replication and increase the safety of an unattenuated, glioblastoma-targeted oncolytic HSV. Mol Ther. 2015 Jan; 23(1):99-107.
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Immunotherapy advances for glioblastoma. Neuro Oncol. 2014 Nov; 16(11):1441-58.
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Skull base chordomas and chondrosarcomas: a population-based analysis. World Neurosurg. 2015 Apr; 83(4):468-70.
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Evolution of malignant glioma treatment: from chemotherapy to vaccines to viruses. Neurosurgery. 2014 Aug; 61 Suppl 1:74-83.
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Annexin A2 regulates angiogenesis and invasion phenotypes of malignant glioma. Neuro Oncol. 2014 Jul; 16 Suppl 3:iii10.
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Cytomegalovirus contributes to glioblastoma in the context of tumor suppressor mutations. Neuro Oncol. 2014 Jul; 16 Suppl 3:iii8.
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Low-grade gliomas and quality of life. World Neurosurg. 2014 Jul-Aug; 82(1-2):e133-4.
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How much is enough? The question of extent of resection in glioblastoma multiforme. World Neurosurg. 2014 Jul-Aug; 82(1-2):e109-10.
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Image-guided maximal resection of intrinsic tumors. World Neurosurg. 2014 Nov; 82(5):604-5.
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Oncolytic viruses targeting tumor stem cells. Cancer Res. 2014 Jul 01; 74(13):3396-8.
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Oncolytic viruses and their application to cancer immunotherapy. Cancer Immunol Res. 2014 Apr; 2(4):295-300.
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Who benefits from surgery for brain metastases? World Neurosurg. 2014 Jul-Aug; 82(1-2):e115-6.
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Phase 1 clinical trial of intratumoral reovirus infusion for the treatment of recurrent malignant gliomas in adults. Mol Ther. 2014 May; 22(5):1056-62.
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No free lunch: secondary neoplasms after stereotactic radiation. World Neurosurg. 2015 Mar; 83(3):330-1.
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Glioma virus therapies between bench and bedside. Neuro Oncol. 2014 Mar; 16(3):334-51.
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Genetic validation of the protein arginine methyltransferase PRMT5 as a candidate therapeutic target in glioblastoma. Cancer Res. 2014 Mar 15; 74(6):1752-65.
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Modification of HSV-1 to an oncolytic virus. Methods Mol Biol. 2014; 1144:117-27.
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Extracellular vesicles modulate the glioblastoma microenvironment via a tumor suppression signaling network directed by miR-1. Cancer Res. 2014 Feb 01; 74(3):738-750.
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Academic productivity in today's training climate: a fellowship's impact. World Neurosurg. 2015 Mar; 83(3):328-9.
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Switching a replication-defective adenoviral vector into a replication-competent, oncolytic adenovirus. J Virol. 2014 Jan; 88(1):345-53.
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Strategies in gene therapy for glioblastoma. Cancers (Basel). 2013 Oct 23; 5(4):1271-305.
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DNA demethylating agents synergize with oncolytic HSV1 against malignant gliomas. Clin Cancer Res. 2013 Nov 01; 19(21):5952-9.
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From localization to pathways: the continuing evolution of diffusion tensor imaging. World Neurosurg. 2014 Jul-Aug; 82(1-2):e47-8.
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Oncolytic virotherapy for gliomas: steps toward the future. CNS Oncol. 2013 Sep; 2(5):389-92.
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Methylation markers of malignant potential in meningiomas. J Neurosurg. 2013 Oct; 119(4):899-906.
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Toxicology and Biodistribution Studies for MGH2.1, an Oncolytic Virus that Expresses Two Prodrug-activating Genes, in Combination with Prodrugs. Mol Ther Nucleic Acids. 2013 Aug 06; 2:e113.
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STAT3 activation promotes oncolytic HSV1 replication in glioma cells. PLoS One. 2013; 8(8):e71932.
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Mutations in glioblastoma oncosuppressive pathways pave the way for oncomodulatory activity of cytomegalovirus. Oncoimmunology. 2013 Sep 01; 2(9):e25620.
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The integrin inhibitor cilengitide enhances the anti-glioma efficacy of vasculostatin-expressing oncolytic virus. Cancer Gene Ther. 2013 Aug; 20(8):437-44.
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Adult cerebellar glioblastomas: a distinct entity or parcel of the whole? World Neurosurg. 2013 Dec; 80(6):e181-3.
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MicroRNA-128 coordinately targets Polycomb Repressor Complexes in glioma stem cells. Neuro Oncol. 2013 Sep; 15(9):1212-24.
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Cytomegalovirus contributes to glioblastoma in the context of tumor suppressor mutations. Cancer Res. 2013 Jun 01; 73(11):3441-50.
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An update on vaccine therapy and other immunotherapeutic approaches for glioblastoma. Expert Rev Vaccines. 2013 Jun; 12(6):597-615.
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Gene expression profiling of the anti-glioma effect of Cilengitide. Springerplus. 2013 Dec; 2(1):160.
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Editorial: Glioblastoma multiforme and laser interstitial thermal therapy. J Neurosurg. 2013 Jun; 118(6):1199-200; discussion 1200-1.
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Uncovering a novel mechanism whereby NK cells interfere with glioblastoma virotherapy. Oncoimmunology. 2013 Apr 01; 2(4):e23658.
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"Infectious" optimism for treatment of hepatocellular carcinoma. Mol Ther. 2013 Apr; 21(4):722-4.
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Editorial: Tumor and antiepileptic drugs: clinical article. J Neurosurg. 2013 Jun; 118(6):1181-2; discussion 1182.
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Editorial: Intraoperative magnetic resonance spectroscopy and gliomas. J Neurosurg. 2013 Jun; 118(6):1188-9; discussion 1189-90.
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Neoplasm development after stereotactic radiosurgery for arteriovenous malformations. World Neurosurg. 2014 Sep-Oct; 82(3-4):304-6.
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Nanotechnology-based strategies for the diagnosis and treatment of intracranial neoplasms. World Neurosurg. 2013 Jul-Aug; 80(1-2):53-5.
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Stereotactic radiosurgery and atypical meningiomas. J Neurosurg. 2013 Aug; 119(2):472-4.
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Editorial: postoperative ischemia. J Neurosurg. 2013 Apr; 118(4):799-800; discussion 800.
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Expression of HSV-1 receptors in EBV-associated lymphoproliferative disease determines susceptibility to oncolytic HSV. Gene Ther. 2013 Jul; 20(7):761-9.
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Comparative effectiveness of antinociceptive gene therapies in animal models of diabetic neuropathic pain. Gene Ther. 2013 Jul; 20(7):742-50.
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The spectrum of vaccine therapies for patients with glioblastoma multiforme. Curr Treat Options Oncol. 2012 Dec; 13(4):437-50.
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NK cells impede glioblastoma virotherapy through NKp30 and NKp46 natural cytotoxicity receptors. Nat Med. 2012 Dec; 18(12):1827-34.
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Quantitative analysis of surgical exposure and maneuverability associated with the endoscope and the microscope in the retrosigmoid and various posterior petrosectomy approaches to the petroclival region using computer tomograpy-based frameless stereotaxy. A cadaveric study. Clin Neurol Neurosurg. 2013 Jul; 115(7):1058-62.
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Proteomics-based analysis of invasion-related proteins in malignant gliomas. Neuropathology. 2013 Jun; 33(3):264-75.
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Editorial: glioblastoma and surgery. J Neurosurg. 2013 Apr; 118(4):809-11; discussion 810-1.
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Effective treatment of an orthotopic xenograft model of human glioblastoma using an EGFR-retargeted oncolytic herpes simplex virus. Mol Ther. 2013 Mar; 21(3):561-9.
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Cytomegalovirus infection leads to pleomorphic rhabdomyosarcomas in Trp53+/- mice. Cancer Res. 2012 Nov 15; 72(22):5669-74.
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Bimodal anti-glioma mechanisms of cilengitide demonstrated by novel invasive glioma models. Neuropathology. 2013 Apr; 33(2):162-74.
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Von Hippel-Lindau disease and pregnancy. J Neurosurg. 2012 Nov; 117(5):815-6; discussion 816-7.
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Editorial: radiosurgery and atypical meningiomas. J Neurosurg. 2012 Oct; 117(4):676-8.
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Editorial: meningioma and radiotherapy. J Neurosurg. 2012 Oct; 117(4):666-8.
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Anti-angiogenic gene therapy in the treatment of malignant gliomas. Neurosci Lett. 2012 Oct 11; 527(2):62-70.
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Editorial: dural tail sign. J Neurosurg. 2012 Oct; 117(4):643-4.
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Editorial: functional neurooncology. J Neurosurg. 2012 Sep; 117(3):463-4; discussion 464-5.
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Copper chelation enhances antitumor efficacy and systemic delivery of oncolytic HSV. Clin Cancer Res. 2012 Sep 15; 18(18):4931-41.
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Oncolytic HSV-1 virotherapy: clinical experience and opportunities for progress. Curr Pharm Biotechnol. 2012 Jul; 13(9):1842-51.
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Stage IV melanoma. J Neurosurg. 2012 Aug; 117(2):225-6; discussion 226.
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Do meningioma patients benefit from antiepileptic drug treatment? World Neurosurg. 2013 Mar-Apr; 79(3-4):433-4.
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Convection-enhanced delivery. J Neurosurg. 2012 Aug; 117(2):193-5; discussion 195-6.
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Treatment for paragangliomas: passing the test of time. World Neurosurg. 2012 May-Jun; 77(5-6):639-41.
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In-training factors predictive of choosing and sustaining a productive academic career path in neurological surgery. Neurosurgery. 2012 Apr; 70(4):1024-32.
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Family history of cancer in benign brain tumor subtypes versus gliomas. Front Oncol. 2012; 2:19.
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The histone deacetylase inhibitor valproic acid lessens NK cell action against oncolytic virus-infected glioblastoma cells by inhibition of STAT5/T-BET signaling and generation of gamma interferon. J Virol. 2012 Apr; 86(8):4566-77.
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Oral tocotrienols are transported to human tissues and delay the progression of the model for end-stage liver disease score in patients. J Nutr. 2012 Mar; 142(3):513-9.
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Perioperative mortality. J Neurosurg. 2012 Apr; 116(4):821-2; discussion 822-4.
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Editorial: urinary tract infection. J Neurosurg. 2012 Apr; 116(4):909; discussion 910.
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Gene and viral therapy for glioblastoma: a review of clinical trials and future directions. Cancer J. 2012 Jan-Feb; 18(1):82-8.
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Reprogramming of the tumour microenvironment by stromal PTEN-regulated miR-320. Nat Cell Biol. 2011 Dec 18; 14(2):159-67.
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Deciphering the Multifaceted Relationship between Oncolytic Viruses and Natural Killer Cells. Adv Virol. 2012; 2012:702839.
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Bringing the endovascular neurosurgeon into the neuro-oncology treatment team. World Neurosurg. 2012 Jan; 77(1):59-61.
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Novel animal glioma models that separately exhibit two different invasive and angiogenic phenotypes of human glioblastomas. World Neurosurg. 2012 Dec; 78(6):670-82.
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Meningioma-toward an improved understanding of the role of sex steroids in tumor development and progression. World Neurosurg. 2011 Nov; 76(5):409-11.
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Understanding glioma invasion: a necessity for effective therapy. World Neurosurg. 2013 Sep-Oct; 80(3-4):281-3.
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Hope and challenges for dendritic cell-based vaccine therapy for glioblastoma. World Neurosurg. 2012 May-Jun; 77(5-6):633-5.
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Molecular and genetic characterization of meningiomas: future predictive assays and "personalized" treatment. World Neurosurg. 2013 Feb; 79(2):247-8.
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Antitumor efficacy of 34.5ENVE: a transcriptionally retargeted and "Vstat120"-expressing oncolytic virus. Mol Ther. 2012 Feb; 20(2):287-97.
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Performing Quality Research in an Era of Reforms. Neurosurgery. 2011 Sep 01; 58(CN_suppl_1):72-78.
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Glioma cell migration on three-dimensional nanofiber scaffolds is regulated by substrate topography and abolished by inhibition of STAT3 signaling. Neoplasia. 2011 Sep; 13(9):831-40.
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Stroke and heart disease: the "also-rans" of radiation exposure. World Neurosurg. 2011 Sep-Oct; 76(3-4):216.
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Clinical and economic outcomes of low-field intraoperative MRI-guided tumor resection neurosurgery. J Magn Reson Imaging. 2011 Nov; 34(5):1022-30.
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Phase IB study of gene-mediated cytotoxic immunotherapy adjuvant to up-front surgery and intensive timing radiation for malignant glioma. J Clin Oncol. 2011 Sep 20; 29(27):3611-9.
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Use of 5-aminolevulinic acid for visualization of low-grade gliomas. J Neurosurg. 2011 Oct; 115(4):737-8; discussion 738-9.
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A viral strategy to ambush tumors. Nat Med. 2011 Jul 07; 17(7):784-5.
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Neoplastic meningitis. J Neurosurg. 2011 Oct; 115(4):728-9; discussion 729.
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Prognosis and treatment of melanoma metastases to the central nervous system: lots of retrospective data, very few certainties. World Neurosurg. 2011 Jul-Aug; 76(1-2):48-50.
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Indirubins decrease glioma invasion by blocking migratory phenotypes in both the tumor and stromal endothelial cell compartments. Cancer Res. 2011 Aug 15; 71(16):5374-80.
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Low Karnofsky Performance Scale score and glioblastoma multiforme. J Neurosurg. 2011 Aug; 115(2):217-8; discussion 218-9.
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Central nervous system cancers. J Natl Compr Canc Netw. 2011 Apr; 9(4):352-400.
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Measuring versus seeing. J Neurosurg. 2011 Jul; 115(1):9-10; discussion 10.
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Extent of resection. J Neurosurg. 2011 Jul; 115(1):1-2; discussion 2.
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Preoperative comorbidity scores and intangible neurosurgical wisdom. World Neurosurg. 2011 Feb; 75(2):215-6.
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Intraoperative MRI (ioMRI) in the setting of awake craniotomies for supratentorial glioma resection. Acta Neurochir Suppl. 2011; 109:43-8.
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Chondroitinase ABC I-mediated enhancement of oncolytic virus spread and antitumor efficacy. Clin Cancer Res. 2011 Mar 15; 17(6):1362-72.
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Finding drugs against CD133+ glioma subpopulations. J Neurosurg. 2011 Mar; 114(3):648; discussion 648-50.
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Potential role of miRNAs and their inhibitors in glioma treatment. Expert Rev Anticancer Ther. 2010 Nov; 10(11):1753-62.
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Long-term outcomes of patients with spinal cord gliomas treated by modern conformal radiation techniques. Int J Radiat Oncol Biol Phys. 2011 Sep 01; 81(1):232-8.
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Multiple craniotomies. J Neurosurg. 2011 Mar; 114(3):574-5; discussion 575.
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Neurosurgical "pearls" and neurosurgical evidence. J Neurosurg. 2010 Aug; 113(2):179; discussion 179-80.
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Treating glioblastoma multiforme with electrical fields. World Neurosurg. 2010 Aug-Sep; 74(2-3):208-11.
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Monoclonal antibodies. J Neurosurg. 2010 Aug; 113(2):190; discussion 190-1.
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Meningioma surgery. J Neurosurg. 2011 Mar; 114(3):695; discussion 696.
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microRNA-451: A conditional switch controlling glioma cell proliferation and migration. Cell Cycle. 2010 Jul 15; 9(14):2742-8.
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A retrospective cohort-matched comparison of conscious sedation versus general anesthesia for supratentorial glioma resection. Clinical article. J Neurosurg. 2011 Mar; 114(3):633-9.
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The many functions of microRNAs in glioblastoma. World Neurosurg. 2010 Jun; 73(6):598-601.
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MicroRNA-451 regulates LKB1/AMPK signaling and allows adaptation to metabolic stress in glioma cells. Mol Cell. 2010 Mar 12; 37(5):620-32.
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Directing systemic oncolytic viral delivery to tumors via carrier cells. Cytokine Growth Factor Rev. 2010 Apr-Jun; 21(2-3):119-26.
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Allergy and inflammatory transcriptome is predominantly negatively correlated with CD133 expression in glioblastoma. Neuro Oncol. 2010 Apr; 12(4):320-7.
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The neuronal microRNA miR-326 acts in a feedback loop with notch and has therapeutic potential against brain tumors. J Neurosci. 2009 Dec 02; 29(48):15161-8.
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Quantitative analysis of complex glioma cell migration on electrospun polycaprolactone using time-lapse microscopy. Tissue Eng Part C Methods. 2009 Dec; 15(4):531-40.
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Enhanced antitumor efficacy of vasculostatin (Vstat120) expressing oncolytic HSV-1. Mol Ther. 2010 Feb; 18(2):285-94.
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"Buy one get one free": armed viruses for the treatment of cancer cells and their microenvironment. Curr Gene Ther. 2009 Oct; 9(5):341-55.
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Anesthesia for brain tumor resection using intraoperative magnetic resonance imaging (iMRI) with the Polestar N-20 system: experience and challenges. J Clin Anesth. 2009 Aug; 21(5):371-6.
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The predictive value of low-field strength magnetic resonance imaging for intraoperative residual tumor detection. Clinical article. J Neurosurg. 2009 Aug; 111(2):252-7.
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Spinal angiography and epidural venography in juvenile muscular atrophy of the distal arm "Hirayama disease". Muscle Nerve. 2009 Aug; 40(2):206-12.
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Reversal of neurological deficit after chemotherapy in BCL-6-positive neurolymphomatosis. Case report. J Neurosurg. 2009 Aug; 111(2):247-51.
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A mathematical model for pattern formation of glioma cells outside the tumor spheroid core. J Theor Biol. 2009 Oct 07; 260(3):359-71.
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Gene- and viral-based therapies for brain tumors. Neurotherapeutics. 2009 Jul; 6(3):547-57.
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Pharmacologic and chemical adjuvants in tumor virotherapy. Chem Rev. 2009 Jul; 109(7):3125-40.
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The Gs-linked receptor GPR3 inhibits the proliferation of cerebellar granule cells during postnatal development. PLoS One. 2009 Jun 15; 4(6):e5922.
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MicroRNAs and glioblastoma; the stem cell connection. Cell Death Differ. 2010 Feb; 17(2):221-8.
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Emerging functions of microRNAs in glioblastoma. J Neurooncol. 2009 May; 92(3):297-306.
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Physiological transgene regulation and functional complementation of a neurological disease gene deficiency in neurons. Mol Ther. 2009 Sep; 17(9):1517-26.
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Design and application of oncolytic HSV vectors for glioblastoma therapy. Expert Rev Neurother. 2009 Apr; 9(4):505-17.
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ICP0 inhibits the decrease of HSV amplicon-mediated transgene expression. Mol Ther. 2009 Apr; 17(4):707-15.
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Phase ib trial of oncolytic herpes virus G207 shows safety of multiple injections and documents viral replication. Mol Ther. 2009 Jan; 17(1):8-9.
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Targeting of the Bmi-1 oncogene/stem cell renewal factor by microRNA-128 inhibits glioma proliferation and self-renewal. Cancer Res. 2008 Nov 15; 68(22):9125-30.
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Modeling the effects of resection, radiation and chemotherapy in glioblastoma. J Neurooncol. 2009 Feb; 91(3):287-93.
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Stable transgene expression from HSV amplicon vectors in the brain: potential involvement of immunoregulatory signals. Mol Ther. 2008 Oct; 16(10):1727-36.
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Lithium inhibits invasion of glioma cells; possible involvement of glycogen synthase kinase-3. Neuro Oncol. 2008 Oct; 10(5):690-9.
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Histone deacetylase inhibitors augment antitumor efficacy of herpes-based oncolytic viruses. Mol Ther. 2008 Sep; 16(9):1546-55.
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Oncolytic HSV-1 infection of tumors induces angiogenesis and upregulates CYR61. Mol Ther. 2008 Aug; 16(8):1382-91.
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microRNA-7 inhibits the epidermal growth factor receptor and the Akt pathway and is down-regulated in glioblastoma. Cancer Res. 2008 May 15; 68(10):3566-72.
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Being old is no fun: treatment of glioblastoma multiforme in the elderly. J Neurosurg. 2008 Apr; 108(4):639-40.
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Efficacy and safety of the oncolytic herpes simplex virus rRp450 alone and combined with cyclophosphamide. Mol Ther. 2008 May; 16(5):879-85.
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The host response to cancer virotherapy. Curr Opin Mol Ther. 2008 Feb; 10(1):38-45.
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A phase I trial of Ad.hIFN-beta gene therapy for glioma. Mol Ther. 2008 Mar; 16(3):618-26.
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Progress and prospects: gene therapy clinical trials (part 2). Gene Ther. 2007 Nov; 14(22):1555-63.
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Depletion of peripheral macrophages and brain microglia increases brain tumor titers of oncolytic viruses. Cancer Res. 2007 Oct 01; 67(19):9398-406.
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Estimating the cell density and invasive radius of three-dimensional glioblastoma tumor spheroids grown in vitro. Appl Opt. 2007 Aug 01; 46(22):5110-8.
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C2/C3 pathologic fractures from polyostotic fibrous dysplasia of the cervical spine treated with percutaneous vertebroplasty. Eur Spine J. 2007 Dec; 16 Suppl 3:250-4.
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Gliomas and venous thromboembolism: how common? J Neurosurg. 2007 Apr; 106(4):599-600; discussion 600.
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A retrospective analysis of reasons for reoperation following initially successful peripheral nerve stimulation. J Neurosurg. 2007 Mar; 106(3):388-90.
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The status of gene therapy for brain tumors. Expert Opin Biol Ther. 2007 Feb; 7(2):197-208.
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Personalizing oncolytic virotherapy? Mol Ther. 2007 Jan; 15(1):6-7.
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GNOSIS: guidelines for neuro-oncology: standards for investigational studies--reporting of surgically based therapeutic clinical trials. J Neurooncol. 2007 Apr; 82(2):211-20.
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Oncolytic viruses: extreme treatment for an extreme disease. Future Microbiol. 2006 Dec; 1(4):351-3.
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Cyclophosphamide increases transgene expression mediated by an oncolytic adenovirus in glioma-bearing mice monitored by bioluminescence imaging. Mol Ther. 2006 Dec; 14(6):779-88.
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Tumor stromal-derived factor-1 recruits vascular progenitors to mitotic neovasculature, where microenvironment influences their differentiated phenotypes. Cancer Res. 2006 Sep 15; 66(18):9054-64.
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Cyclophosphamide enhances glioma virotherapy by inhibiting innate immune responses. Proc Natl Acad Sci U S A. 2006 Aug 22; 103(34):12873-8.
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Imaging immediate-early and strict-late promoter activity during oncolytic herpes simplex virus type 1 infection and replication in tumors. Gene Ther. 2006 Dec; 13(24):1731-6.
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Gene therapeutics: the future of brain tumor therapy? Expert Rev Anticancer Ther. 2006 Jul; 6(7):1053-64.
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Gene therapy for glioblastoma. Neurosurg Focus. 2006 Apr 15; 20(4):E18.
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Brain tumor imaging and surgical management: the neurosurgeon's perspective. Top Magn Reson Imaging. 2006 Apr; 17(2):121-6.
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Development of a rapid method to generate multiple oncolytic HSV vectors and their in vivo evaluation using syngeneic mouse tumor models. Gene Ther. 2006 Apr; 13(8):705-14.
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Genetic strategies for brain tumor therapy. Cancer Gene Ther. 2006 Mar; 13(3):225-33.
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Glioma virotherapy: effects of innate immune suppression and increased viral replication capacity. Cancer Res. 2006 Feb 15; 66(4):2314-9.
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Cyclophosphamide allows for in vivo dose reduction of a potent oncolytic virus. Cancer Res. 2005 Dec 15; 65(24):11255-8.
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Tissue inhibitor of metalloproteinase-3 expression from an oncolytic adenovirus inhibits matrix metalloproteinase activity in vivo without affecting antitumor efficacy in malignant glioma. Cancer Res. 2005 Oct 15; 65(20):9398-405.
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Central nervous system cancers: Clinical Practice Guidelines in Oncology. J Natl Compr Canc Netw. 2005 Sep; 3(5):644-90.
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Contribution of bone marrow-derived cells to blood vessels in ischemic tissues and tumors. Mol Ther. 2005 Dec; 12(6):994-1005.
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885 Braingate: Turning Thought into Action-First Experience with a Human Neuromotor Prosthesis. Neurosurgery. 2005 Aug 01; 57(2):425.
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Brain tumor oncolysis with replication-conditional herpes simplex virus type 1 expressing the prodrug-activating genes, CYP2B1 and secreted human intestinal carboxylesterase, in combination with cyclophosphamide and irinotecan. Cancer Res. 2005 Aug 01; 65(15):6850-7.
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Diagnostic criteria for schwannomatosis. Neurology. 2005 Jun 14; 64(11):1838-45.
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An oncolytic HSV-1 mutant expressing ICP34.5 under control of a nestin promoter increases survival of animals even when symptomatic from a brain tumor. Cancer Res. 2005 Apr 01; 65(7):2832-9.
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A phase I open-label, dose-escalation, multi-institutional trial of injection with an E1B-Attenuated adenovirus, ONYX-015, into the peritumoral region of recurrent malignant gliomas, in the adjuvant setting. Mol Ther. 2004 Nov; 10(5):958-66.
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Infectious delivery of the 132 kb CDKN2A/CDKN2B genomic DNA region results in correctly spliced gene expression and growth suppression in glioma cells. Gene Ther. 2004 Aug; 11(15):1195-204.
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[Molecular imaging of transgene expression in brain tumors]. No Shinkei Geka. 2004 Aug; 32(8):805-24.
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Neurosurgical delivery of chemotherapeutics, targeted toxins, genetic and viral therapies in neuro-oncology. J Neurooncol. 2004 Aug-Sep; 69(1-3):101-17.
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The combination of adenoviral HSV TK gene therapy and radiation is effective in athymic mouse glioblastoma xenografts without increasing toxic side effects. J Neurooncol. 2004 Mar-Apr; 67(1-2):177-88.
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Replicative oncolytic herpes simplex viruses in combination cancer therapies. Curr Gene Ther. 2004 Mar; 4(1):41-51.
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Glial tumor grading and outcome prediction using dynamic spin-echo MR susceptibility mapping compared with conventional contrast-enhanced MR: confounding effect of elevated rCBV of oligodendrogliomas [corrected]. AJNR Am J Neuroradiol. 2004 Feb; 25(2):214-21.
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Altered expression of antiviral cytokine mRNAs associated with cyclophosphamide's enhancement of viral oncolysis. Gene Ther. 2004 Jan; 11(2):214-23.
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Cytochrome p450-based gene therapies for cancer. Methods Mol Med. 2004; 90:203-22.
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An HSV amplicon-based helper system for helper-dependent adenoviral vectors. Biochem Biophys Res Commun. 2003 Aug 08; 307(4):826-30.
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Development of a novel non-human primate model for preclinical gene vector safety studies. Determining the effects of intracerebral HSV-1 inoculation in the common marmoset: a comparative study. Gene Ther. 2003 Aug; 10(15):1225-33.
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Gene therapy: a primer for neurosurgeons. Neurosurgery. 2003 Aug; 53(2):364-73; discussion 373.
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Functional response of tumor vasculature to PaCO2: determination of total and microvascular blood volume by MRI. Neoplasia. 2003 Jul-Aug; 5(4):330-8.
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Effects of innate immunity on herpes simplex virus and its ability to kill tumor cells. Gene Ther. 2003 Jun; 10(11):983-90.
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Potentiated gene delivery to tumors using herpes simplex virus/Epstein-Barr virus/RV tribrid amplicon vectors. Hum Gene Ther. 2003 May 01; 14(7):611-26.
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PTEN decreases in vivo vascularization of experimental gliomas in spite of proangiogenic stimuli. Cancer Res. 2003 May 01; 63(9):2300-5.
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Infectious delivery of a 135-kb LDLR genomic locus leads to regulated complementation of low-density lipoprotein receptor deficiency in human cells. Mol Ther. 2003 May; 7(5 Pt 1):604-12.
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Viral therapy for glioblastoma. Cancer J. 2003 May-Jun; 9(3):167-79.
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Oncolytic viruses for the therapy of brain tumors and other solid malignancies: a review. Front Biosci. 2003 May 01; 8:e346-60.
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Genetically engineered herpes simplex viral vectors in the treatment of brain tumors: a review. Cancer Invest. 2003 Apr; 21(2):278-92.
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Improved HSV-1 amplicon packaging system using ICP27-deleted, oversized HSV-1 BAC DNA. Methods Mol Med. 2003; 76:51-60.
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In vivo 3-T MR spectroscopy in the distinction of recurrent glioma versus radiation effects: initial experience. Radiology. 2002 Dec; 225(3):871-9.
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MRI of transgene expression: correlation to therapeutic gene expression. Neoplasia. 2002 Nov-Dec; 4(6):523-30.
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Prodrug bioactivation and oncolysis of diffuse liver metastases by a herpes simplex virus 1 mutant that expresses the CYP2B1 transgene. Cancer. 2002 Sep 01; 95(5):1171-81.
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Regulation of herpes simplex virus gamma(1)34.5 expression and oncolysis of diffuse liver metastases by Myb34.5. J Clin Invest. 2002 Apr; 109(7):871-82.
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Intra-arterial delivery of p53-containing adenoviral vector into experimental brain tumors. Cancer Gene Ther. 2002 Mar; 9(3):228-35.
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Guided genes for tumor warfare. Nat Biotechnol. 2002 Mar; 20(3):235-6.
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The complement response against an oncolytic virus is species-specific in its activation pathways. Mol Ther. 2002 Mar; 5(3):275-82.
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Massive growth of a meningioma into the brachial plexus and thoracic cavity after intraspinal and supraclavicular resection. Case report and review of the literature. J Neurosurg. 2002 Jan; 96(1 Suppl):107-11.
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An infectious transfer and expression system for genomic DNA loci in human and mouse cells. Nat Biotechnol. 2001 Nov; 19(11):1067-70.
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Comparative analyses of transgene delivery and expression in tumors inoculated with a replication-conditional or -defective viral vector. Cancer Res. 2001 Jul 15; 61(14):5336-9.
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Improved helper virus-free packaging system for HSV amplicon vectors using an ICP27-deleted, oversized HSV-1 DNA in a bacterial artificial chromosome. Mol Ther. 2001 Apr; 3(4):591-601.
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Intraneoplastic polymer-based delivery of cyclophosphamide for intratumoral bioconversion by a replicating oncolytic viral vector. Cancer Res. 2001 Feb 01; 61(3):864-8.
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