Gordon J. Freeman, PhD

Gordon J. Freeman, PhD

Researcher

Contact Information

Office Phone Number

(617) 632-4585

Fax

(617) 632-5167

Biography

Gordon J. Freeman, PhD

Gordon Freeman, PhD, Professor of Medicine at Dana-Farber Cancer Institute and Harvard Medical School, is renowned for discovering the PD-L1 and PD-L2 proteins. Dr. Freeman showed that PD-L1 and PD-L2 bound to PD-1 to turn off the immune response and that blockade of PD-L1/PD-1 enhanced immune responses.  He further showed that PD-L1 is highly expressed on many tumors and allows these tumors to resist immune attack. Dr. Freeman’s work led directly to the development of a successful strategy for cancer immunotherapy - blocking the PD-1-ligand interaction. Dr. Freeman has published over 400 scientific papers and holds over 90 US patents on immunotherapies. He was elected to the National Academy of Sciences and the National Academy of Inventors, is a Fellow of the AACR and SITC Academies, and has received numerous awards, including the William B. Coley Award for Distinguished Research in Tumor Immunology, the Warren Alpert Foundation Prize, and the Richard Smalley, MD, Memorial Award. Dr. Freeman received his Ph.D. degree in Microbiology and Molecular Genetics from Harvard University.

Researcher

Physician

Professor of Medicine, Harvard Medical School
Adjunct, Department of Immunology and Virology

Centers/Programs

Recent Awards

  • Damon Runyon-Walter Winchell Fellowship 1980
  • Fellowship, American Cancer Society 1982
  • Institute of Scientific Information highly cited researcher in Imunology 2003

Research

    About the Freeman Lab

    The Freeman Laboratory studies the contribution of costimulatory signals to the immune response. Following the discovery of PD-L1 and PD-L2 as the ligands for the PD-1 receptor on T cells, we demonstrated the inhibitory function of PD-L1 and PD-L2 on T cells and showed that blockade of this pathway enhanced T cell activation, proliferation, and cytokine production. Further studies showed that PD-L1 is highly expressed by many solid tumors/hematological malignancies, and that blockade of PD-L1 enhances killing of PD-L1 positive targets by CD8 T cells. Recently, PD-1 blocking antibodies were approved by the FDA for the treatment of melanoma and lung cancer.

    Our group also discovered the B7-1 and B7-2 molecules that bind to the costimulatory CD28 and coinhibitory CTLA-4 receptor and provide the critical costimulatory signal for full T cell activation, clonal expansion, and development of effector function through their interaction with CD28 on T cells. Following T cell activation, the B7-1–B7-2 interaction with CTLA-4, expressed on activated T cells, leads to down-regulation of T cell activation, whereas stimulation of the TCR alone leads to T cell clonal anergy. Thus, blockade of B7-1 and B7-2 can be used to establish antigen-specific tolerance for transplantation or the alleviation of autoimmunity.

    Conversely, B7-1/B7-2 expression can stimulate an immune response, and the introduction of B7-1 or B7-2 into tumors can stimulate an anti-tumor response leading to tumor rejection and anti-tumor immunity. Recently, we have cloned two novel members of the B7 gene family, which bind to receptors expressed on activated T cells and further regulate the development of an immune response. Current studies focus on the function of these novel B7 genes and their interactions with the B7/CD28-CTLA-4 pathway.

    Publications

      • Formate supplementation enhances anti-tumor CD8+ T cell fitness and efficacy of PD-1 blockade. Cancer Discov. 2023 Sep 20. View in: Pubmed

      • The CX3CL1-CX3CR1 chemokine axis can contribute to tumor immune evasion and blockade with a novel CX3CR1 monoclonal antibody enhances response to anti-PD-1 immunotherapy. Front Immunol. 2023; 14:1237715. View in: Pubmed

      • PD-1 blockade increases the self-renewal of stem-like CD8 T cells to compensate for their accelerated differentiation into effectors. Sci Immunol. 2023 08 04; 8(86):eadg0539. View in: Pubmed

      • Inverse relationship between Fusobacterium nucleatum amount and tumor CD274 (PD-L1) expression in colorectal carcinoma. Clin Transl Immunology. 2023; 12(8):e1453. View in: Pubmed

      • Novel Antimurine Thyroid-Stimulating Hormone Receptor Monoclonal Antibodies. Monoclon Antib Immunodiagn Immunother. 2023 Jun; 42(3):109-114. View in: Pubmed

      • Publisher Correction: Targeting PD-L2-RGMb overcomes microbiome-related immunotherapy resistance. Nature. 2023 Jun; 618(7966):E27. View in: Pubmed

      • PRMT1 mediated methylation of cGAS suppresses anti-tumor immunity. Nat Commun. 2023 05 17; 14(1):2806. View in: Pubmed

      • Targeting PD-L2-RGMb overcomes microbiome-related immunotherapy resistance. Nature. 2023 May; 617(7960):377-385. View in: Pubmed

      • PI3Kß controls immune evasion in PTEN-deficient breast tumours. Nature. 2023 May; 617(7959):139-146. View in: Pubmed

      • mTORC1 upregulates B7-H3/CD276 to inhibit antitumor T cells and drive tumor immune evasion. Nat Commun. 2023 03 03; 14(1):1214. View in: Pubmed

      • Losartan controls immune checkpoint blocker-induced edema and improves survival in glioblastoma mouse models. Proc Natl Acad Sci U S A. 2023 02 07; 120(6):e2219199120. View in: Pubmed

      • mTOR regulates T cell exhaustion and PD-1-targeted immunotherapy response during chronic viral infection. J Clin Invest. 2023 01 17; 133(2). View in: Pubmed

      • STING agonism overcomes STAT3-mediated immunosuppression and adaptive resistance to PARP inhibition in ovarian cancer. J Immunother Cancer. 2023 01; 11(1). View in: Pubmed

      • Optimized ACE2 decoys neutralize antibody-resistant SARS-CoV-2 variants through functional receptor mimicry and treat infection in vivo. Sci Adv. 2022 12 09; 8(49):eabq6527. View in: Pubmed

      • Immunoregulatory effects of RGMb in gut inflammation. Front Immunol. 2022; 13:960329. View in: Pubmed

      • PD-1 combination therapy with IL-2 modifies CD8+ T cell exhaustion program. Nature. 2022 10; 610(7930):173-181. View in: Pubmed

      • Preclinical models for development of immune-oncology therapies. Immuno-oncol Insights. 2022; 3(8):379-398. View in: Pubmed

      • Immune checkpoint expression on HIV-specific CD4+ T cells and response to their blockade are dependent on lineage and function. EBioMedicine. 2022 Oct; 84:104254. View in: Pubmed

      • Transcriptomic Correlates of Tumor Cell PD-L1 Expression and Response to Nivolumab Monotherapy in Metastatic Clear Cell Renal Cell Carcinoma. Clin Cancer Res. 2022 09 15; 28(18):4045-4055. View in: Pubmed

      • PD-1 blockade following ART interruption enhances control of pathogenic SIV in rhesus macaques. Proc Natl Acad Sci U S A. 2022 08 16; 119(33):e2202148119. View in: Pubmed

      • A Comparison of Murine PD-1 and PD-L1 Monoclonal Antibodies. Monoclon Antib Immunodiagn Immunother. 2022 Aug; 41(4):202-209. View in: Pubmed

      • Tumor cells dictate anti-tumor immune responses by altering pyruvate utilization and succinate signaling in CD8+ T cells. Cell Metab. 2022 08 02; 34(8):1137-1150.e6. View in: Pubmed

      • Insights into Immune Escape During Tumor Evolution and Response to Immunotherapy Using a Rat Model of Breast Cancer. Cancer Immunol Res. 2022 06 03; 10(6):680-697. View in: Pubmed

      • The Programmed Death-1 Pathway Counter-Regulates Inflammation-Induced Osteoclast Activity in Clinical and Experimental Settings. Front Immunol. 2022; 13:773946. View in: Pubmed

      • Soluble PD-L1 as an early marker of progressive disease on nivolumab. J Immunother Cancer. 2022 02; 10(2). View in: Pubmed

      • Anti-CAIX BB? CAR4/8 T cells exhibit superior efficacy in a ccRCC mouse model. Mol Ther Oncolytics. 2022 Mar 17; 24:385-399. View in: Pubmed

      • Monitoring PD-1 Phosphorylation to Evaluate PD-1 Signaling during Antitumor Immune Responses. Cancer Immunol Res. 2021 12; 9(12):1465-1475. View in: Pubmed

      • PD-1 blockade and vaccination provide therapeutic benefit against SIV by inducing broad and functional CD8+ T cells in lymphoid tissue. Sci Immunol. 2021 Sep 10; 6(63):eabh3034. View in: Pubmed

      • ULK1 inhibition overcomes compromised antigen presentation and restores antitumor immunity in LKB1 mutant lung cancer. Nat Cancer. 2021 05; 2(5):503-514. View in: Pubmed

      • Emerging concepts in PD-1 checkpoint biology. Semin Immunol. 2021 02; 52:101480. View in: Pubmed

      • Leukemia vaccine overcomes limitations of checkpoint blockade by evoking clonal T cell responses in a murine acute myeloid leukemia model. Haematologica. 2021 05 01; 106(5):1330-1342. View in: Pubmed

      • Energy status dictates PD-L1 protein abundance and anti-tumor immunity to enable checkpoint blockade. Mol Cell. 2021 06 03; 81(11):2317-2331.e6. View in: Pubmed

      • Spatial signatures identify immune escape via PD-1 as a defining feature of T-cell/histiocyte-rich large B-cell lymphoma. Blood. 2021 03 11; 137(10):1353-1364. View in: Pubmed

      • Association of Fusobacterium nucleatum with Specific T-cell Subsets in the Colorectal Carcinoma Microenvironment. Clin Cancer Res. 2021 05 15; 27(10):2816-2826. View in: Pubmed

      • Epitope spreading toward wild-type melanocyte-lineage antigens rescues suboptimal immune checkpoint blockade responses. Sci Transl Med. 2021 02 17; 13(581). View in: Pubmed

      • Therapeutically Increasing MHC-I Expression Potentiates Immune Checkpoint Blockade. Cancer Discov. 2021 06; 11(6):1524-1541. View in: Pubmed

      • Inhibitory CD161 receptor identified in glioma-infiltrating T cells by single-cell analysis. Cell. 2021 03 04; 184(5):1281-1298.e26. View in: Pubmed

      • VISTA: A Mediator of Quiescence and a Promising Target in Cancer Immunotherapy. Trends Immunol. 2021 03; 42(3):209-227. View in: Pubmed

      • PD-1 blockade exacerbates Mycobacterium tuberculosis infection in rhesus macaques. Sci Immunol. 2021 01 15; 6(55). View in: Pubmed

      • PD-1 restraint of regulatory T cell suppressive activity is critical for immune tolerance. J Exp Med. 2021 01 04; 218(1). View in: Pubmed

      • Concurrent Dexamethasone Limits the Clinical Benefit of Immune Checkpoint Blockade in Glioblastoma. Clin Cancer Res. 2021 01 01; 27(1):276-287. View in: Pubmed

      • KIR3DL3 Is an Inhibitory Receptor for HHLA2 that Mediates an Alternative Immunoinhibitory Pathway to PD1. Cancer Immunol Res. 2021 02; 9(2):156-169. View in: Pubmed

      • Expression of T-Cell Exhaustion Molecules and Human Endogenous Retroviruses as Predictive Biomarkers for Response to Nivolumab in Metastatic Clear Cell Renal Cell Carcinoma. Clin Cancer Res. 2021 03 01; 27(5):1371-1380. View in: Pubmed

      • Clonal tracing reveals diverse patterns of response to immune checkpoint blockade. Genome Biol. 2020 10 15; 21(1):263. View in: Pubmed

      • Acetylation-dependent regulation of PD-L1 nuclear translocation dictates the efficacy of anti-PD-1 immunotherapy. Nat Cell Biol. 2020 09; 22(9):1064-1075. View in: Pubmed

      • The PD-1 Pathway Regulates Development and Function of Memory CD8+ T Cells following Respiratory Viral Infection. Cell Rep. 2020 06 30; 31(13):107827. View in: Pubmed

      • Retinoblastoma protein expression and its predictors in triple-negative breast cancer. NPJ Breast Cancer. 2020 Jun 05; 6(1):19. View in: Pubmed

      • Retinoblastoma protein expression and its predictors in triple-negative breast cancer. NPJ Breast Cancer. 2020; 6:19. View in: Pubmed

      • Interplay of somatic alterations and immune infiltration modulates response to PD-1 blockade in advanced clear cell renal cell carcinoma. Nat Med. 2020 06; 26(6):909-918. View in: Pubmed

      • Inactivation of Fbxw7 Impairs dsRNA Sensing and Confers Resistance to PD-1 Blockade. Cancer Discov. 2020 09; 10(9):1296-1311. View in: Pubmed

      • Interaction of SHP-2 SH2 domains with PD-1 ITSM induces PD-1 dimerization and SHP-2 activation. Commun Biol. 2020 03 17; 3(1):128. View in: Pubmed

      • The importance of exosomal PDL1 in tumour immune evasion. Nat Rev Immunol. 2020 04; 20(4):209-215. View in: Pubmed

      • Acidity changes immunology: a new VISTA pathway. Nat Immunol. 2020 01; 21(1):13-16. View in: Pubmed

      • CDK7 Inhibition Potentiates Genome Instability Triggering Anti-tumor Immunity in Small Cell Lung Cancer. Cancer Cell. 2020 01 13; 37(1):37-54.e9. View in: Pubmed

      • Programmed death ligand 2 - A link between inflammation and bone loss in rheumatoid arthritis. J Transl Autoimmun. 2020; 3:100028. View in: Pubmed

      • Proliferating Transitory T Cells with an Effector-like Transcriptional Signature Emerge from PD-1+ Stem-like CD8+ T Cells during Chronic Infection. Immunity. 2019 12 17; 51(6):1043-1058.e4. View in: Pubmed

      • Results of a Multicenter Phase II Study of Atezolizumab and Bevacizumab for Patients With Metastatic Renal Cell Carcinoma With Variant Histology and/or Sarcomatoid Features. J Clin Oncol. 2020 01 01; 38(1):63-70. View in: Pubmed

      • Blockade of TIM-1 on the donor graft ameliorates graft-versus-host disease following hematopoietic cell transplantation. Blood Adv. 2019 11 12; 3(21):3419-3431. View in: Pubmed

      • Metabolomic adaptations and correlates of survival to immune checkpoint blockade. Nat Commun. 2019 09 25; 10(1):4346. View in: Pubmed

      • PTPN2 regulates the generation of exhausted CD8+ T cell subpopulations and restrains tumor immunity. Nat Immunol. 2019 10; 20(10):1335-1347. View in: Pubmed

      • Immuno-PET identifies the myeloid compartment as a key contributor to the outcome of the antitumor response under PD-1 blockade. Proc Natl Acad Sci U S A. 2019 08 20; 116(34):16971-16980. View in: Pubmed

      • PD-L1 Expression and Clinical Outcomes to Cabozantinib, Everolimus, and Sunitinib in Patients with Metastatic Renal Cell Carcinoma: Analysis of the Randomized Clinical Trials METEOR and CABOSUN. Clin Cancer Res. 2019 10 15; 25(20):6080-6088. View in: Pubmed

      • Author Correction: Cyclin D-CDK4 kinase destabilizes PD-L1 via cullin 3-SPOP to control cancer immune surveillance. Nature. 2019 Jul; 571(7766):E10. View in: Pubmed

      • Intratumoral Activity of the CXCR3 Chemokine System Is Required for the Efficacy of Anti-PD-1 Therapy. Immunity. 2019 06 18; 50(6):1498-1512.e5. View in: Pubmed

      • Immune Profiling and Quantitative Analysis Decipher the Clinical Role of Immune-Checkpoint Expression in the Tumor Immune Microenvironment of DLBCL. Cancer Immunol Res. 2019 04; 7(4):644-657. View in: Pubmed

      • Blockade of RGMb inhibits allergen-induced airways disease. J Allergy Clin Immunol. 2019 07; 144(1):94-108.e11. View in: Pubmed

      • Anti-PD-1/PD-L1 therapy augments lenvatinib's efficacy by favorably altering the immune microenvironment of murine anaplastic thyroid cancer. Int J Cancer. 2019 05 01; 144(9):2266-2278. View in: Pubmed

      • irRECIST for the Evaluation of Candidate Biomarkers of Response to Nivolumab in Metastatic Clear Cell Renal Cell Carcinoma: Analysis of a Phase II Prospective Clinical Trial. Clin Cancer Res. 2019 04 01; 25(7):2174-2184. View in: Pubmed

      • A secreted PD-L1 splice variant that covalently dimerizes and mediates immunosuppression. Cancer Immunol Immunother. 2019 Mar; 68(3):421-432. View in: Pubmed

      • PARP Inhibition Elicits STING-Dependent Antitumor Immunity in Brca1-Deficient Ovarian Cancer. Cell Rep. 2018 12 11; 25(11):2972-2980.e5. View in: Pubmed

      • Successful Anti-PD-1 Cancer Immunotherapy Requires T Cell-Dendritic Cell Crosstalk Involving the Cytokines IFN-? and IL-12. Immunity. 2018 12 18; 49(6):1148-1161.e7. View in: Pubmed

      • Combinations of BRAF inhibitor and anti-PD-1/PD-L1 antibody improve survival and tumour immunity in an immunocompetent model of orthotopic murine anaplastic thyroid cancer. Br J Cancer. 2018 11; 119(10):1223-1232. View in: Pubmed

      • Arming an Oncolytic Herpes Simplex Virus Type 1 with a Single-chain Fragment Variable Antibody against PD-1 for Experimental Glioblastoma Therapy. Clin Cancer Res. 2019 01 01; 25(1):290-299. View in: Pubmed

      • Combination anti-PD-1 and antiretroviral therapy provides therapeutic benefit against SIV. JCI Insight. 2018 09 20; 3(18). View in: Pubmed

      • CD160 Stimulates CD8+ T Cell Responses and Is Required for Optimal Protective Immunity to Listeria monocytogenes. Immunohorizons. 2018 08 27; 2(7):238-250. View in: Pubmed

      • Signatures of T cell dysfunction and exclusion predict cancer immunotherapy response. Nat Med. 2018 10; 24(10):1550-1558. View in: Pubmed

      • BET Bromodomain Inhibition Cooperates with PD-1 Blockade to Facilitate Antitumor Response in Kras-Mutant Non-Small Cell Lung Cancer. Cancer Immunol Res. 2018 10; 6(10):1234-1245. View in: Pubmed

      • Immune Checkpoint Blockade Restores HIV-Specific CD4 T Cell Help for NK Cells. J Immunol. 2018 08 01; 201(3):971-981. View in: Pubmed

      • LSD1 Ablation Stimulates Anti-tumor Immunity and Enables Checkpoint Blockade. Cell. 2018 07 26; 174(3):549-563.e19. View in: Pubmed

      • PD-L1 Binds to B7-1 Only In Cis on the Same Cell Surface. Cancer Immunol Res. 2018 08; 6(8):921-929. View in: Pubmed

      • TSC2-deficient tumors have evidence of T cell exhaustion and respond to anti-PD-1/anti-CTLA-4 immunotherapy. JCI Insight. 2018 04 19; 3(8). View in: Pubmed

      • Role of PD-1 during effector CD8 T cell differentiation. Proc Natl Acad Sci U S A. 2018 05 01; 115(18):4749-4754. View in: Pubmed

      • TIME (Tumor Immunity in the MicroEnvironment) classification based on tumor CD274 (PD-L1) expression status and tumor-infiltrating lymphocytes in colorectal carcinomas. Oncoimmunology. 2018; 7(7):e1442999. View in: Pubmed

      • Dendritic Cell PD-L1 Limits Autoimmunity and Follicular T Cell Differentiation and Function. J Immunol. 2018 04 15; 200(8):2592-2602. View in: Pubmed

      • Immune evasion mediated by PD-L1 on glioblastoma-derived extracellular vesicles. Sci Adv. 2018 03; 4(3):eaar2766. View in: Pubmed

      • Preclinical investigation of combined gene-mediated cytotoxic immunotherapy and immune checkpoint blockade in glioblastoma. Neuro Oncol. 2018 01 22; 20(2):225-235. View in: Pubmed

      • Modeling tumor immunity of mouse glioblastoma by exhausted CD8+ T cells. Sci Rep. 2018 01 09; 8(1):208. View in: Pubmed

      • T cell-targeting nanoparticles focus delivery of immunotherapy to improve antitumor immunity. Nat Commun. 2017 11 23; 8(1):1747. View in: Pubmed

      • Cyclin D-CDK4 kinase destabilizes PD-L1 via cullin 3-SPOP to control cancer immune surveillance. Nature. 2018 01 04; 553(7686):91-95. View in: Pubmed

      • Ex Vivo Profiling of PD-1 Blockade Using Organotypic Tumor Spheroids. Cancer Discov. 2018 02; 8(2):196-215. View in: Pubmed

      • CDK4/6 Inhibition Augments Antitumor Immunity by Enhancing T-cell Activation. Cancer Discov. 2018 02; 8(2):216-233. View in: Pubmed

      • Tumor PDCD1LG2 (PD-L2) Expression and the Lymphocytic Reaction to Colorectal Cancer. Cancer Immunol Res. 2017 11; 5(11):1046-1055. View in: Pubmed

      • PD-1 Status in CD8+ T Cells Associates with Survival and Anti-PD-1 Therapeutic Outcomes in Head and Neck Cancer. Cancer Res. 2017 11 15; 77(22):6353-6364. View in: Pubmed

      • Topological analysis reveals a PD-L1-associated microenvironmental niche for Reed-Sternberg cells in Hodgkin lymphoma. Blood. 2017 11 30; 130(22):2420-2430. View in: Pubmed

      • Enhancing CD8+ T Cell Fatty Acid Catabolism within a Metabolically Challenging Tumor Microenvironment Increases the Efficacy of Melanoma Immunotherapy. Cancer Cell. 2017 09 11; 32(3):377-391.e9. View in: Pubmed

      • Immune Escape in Breast Cancer During In Situ to Invasive Carcinoma Transition. Cancer Discov. 2017 10; 7(10):1098-1115. View in: Pubmed

      • Soluble PD-L1 as a Biomarker in Malignant Melanoma Treated with Checkpoint Blockade. Cancer Immunol Res. 2017 06; 5(6):480-492. View in: Pubmed

      • Labeling Extracellular Vesicles for Nanoscale Flow Cytometry. Sci Rep. 2017 05 12; 7(1):1878. View in: Pubmed

      • In vivo imaging reveals a tumor-associated macrophage-mediated resistance pathway in anti-PD-1 therapy. Sci Transl Med. 2017 05 10; 9(389). View in: Pubmed

      • Differential Expression of PD-L1 in High Grade T1 vs Muscle Invasive Bladder Carcinoma and its Prognostic Implications. J Urol. 2017 10; 198(4):817-823. View in: Pubmed

      • Interleukin-17A Promotes Lung Tumor Progression through Neutrophil Attraction to Tumor Sites and Mediating Resistance to PD-1 Blockade. J Thorac Oncol. 2017 08; 12(8):1268-1279. View in: Pubmed

      • Aspirin Use and Colorectal Cancer Survival According to Tumor CD274 (Programmed Cell Death 1 Ligand 1) Expression Status. J Clin Oncol. 2017 Jun 01; 35(16):1836-1844. View in: Pubmed

      • PD-L1 on tumor cells is sufficient for immune evasion in immunogenic tumors and inhibits CD8 T cell cytotoxicity. J Exp Med. 2017 04 03; 214(4):895-904. View in: Pubmed

      • Rescue of exhausted CD8 T cells by PD-1-targeted therapies is CD28-dependent. Science. 2017 03 31; 355(6332):1423-1427. View in: Pubmed

      • Loss of PTEN Is Associated with Resistance to Anti-PD-1 Checkpoint Blockade Therapy in Metastatic Uterine Leiomyosarcoma. Immunity. 2017 02 21; 46(2):197-204. View in: Pubmed

      • Proceedings of the third international molecular pathological epidemiology (MPE) meeting. Cancer Causes Control. 2017 02; 28(2):167-176. View in: Pubmed

      • Increased expression of programmed death ligand 1 (PD-L1) in human pituitary tumors. Oncotarget. 2016 Nov 22; 7(47):76565-76576. View in: Pubmed

      • 5-Fluorouracil upregulates cell surface B7-H1 (PD-L1) expression in gastrointestinal cancers. J Immunother Cancer. 2016; 4:65. View in: Pubmed

      • Type 2 innate lymphoid cell suppression by regulatory T cells attenuates airway hyperreactivity and requires inducible T-cell costimulator-inducible T-cell costimulator ligand interaction. J Allergy Clin Immunol. 2017 May; 139(5):1468-1477.e2. View in: Pubmed

      • Defining CD8+ T cells that provide the proliferative burst after PD-1 therapy. Nature. 2016 09 15; 537(7620):417-421. View in: Pubmed

      • Synergy of radiotherapy and PD-1 blockade in Kras-mutant lung cancer. JCI Insight. 2016 06 16; 1(9):e87415. View in: Pubmed

      • Immune Profiling of Adenoid Cystic Carcinoma: PD-L2 Expression and Associations with Tumor-Infiltrating Lymphocytes. Cancer Immunol Res. 2016 08; 4(8):679-87. View in: Pubmed

      • Programmed death ligand-1 expression on donor T cells drives graft-versus-host disease lethality. J Clin Invest. 2016 07 01; 126(7):2642-60. View in: Pubmed

      • Correlation of Apobec Mrna Expression with overall Survival and pd-l1 Expression in Urothelial Carcinoma. Sci Rep. 2016 06 10; 6:27702. View in: Pubmed

      • Chimeric antigen receptor T cells secreting anti-PD-L1 antibodies more effectively regress renal cell carcinoma in a humanized mouse model. Oncotarget. 2016 Jun 07; 7(23):34341-55. View in: Pubmed

      • Nivolumab in Patients With Relapsed or Refractory Hematologic Malignancy: Preliminary Results of a Phase Ib Study. J Clin Oncol. 2016 08 10; 34(23):2698-704. View in: Pubmed

      • Abundant PD-L1 expression in Epstein-Barr Virus-infected gastric cancers. Oncotarget. 2016 May 31; 7(22):32925-32. View in: Pubmed

      • Coinhibitory Pathways in the B7-CD28 Ligand-Receptor Family. Immunity. 2016 05 17; 44(5):955-72. View in: Pubmed

      • Learning from PD-1 Resistance: New Combination Strategies. Trends Mol Med. 2016 06; 22(6):448-451. View in: Pubmed

      • Tumour CD274 (PD-L1) expression and T cells in colorectal cancer. Gut. 2017 08; 66(8):1463-1473. View in: Pubmed

      • PD-L1 and PD-L2 Genetic Alterations Define Classical Hodgkin Lymphoma and Predict Outcome. J Clin Oncol. 2016 08 10; 34(23):2690-7. View in: Pubmed

      • Genetic Basis for PD-L1 Expression in Squamous Cell Carcinomas of the Cervix and Vulva. JAMA Oncol. 2016 Apr; 2(4):518-22. View in: Pubmed

      • Expression of Programmed Cell Death 1 Ligands (PD-L1 and PD-L2) in Histiocytic and Dendritic Cell Disorders. Am J Surg Pathol. 2016 Apr; 40(4):443-53. View in: Pubmed

      • Combining BRAF inhibitor and anti PD-L1 antibody dramatically improves tumor regression and anti tumor immunity in an immunocompetent murine model of anaplastic thyroid cancer. Oncotarget. 2016 Mar 29; 7(13):17194-211. View in: Pubmed

      • Coinhibitory Pathways in Immunotherapy for Cancer. Annu Rev Immunol. 2016 05 20; 34:539-73. View in: Pubmed

      • Repulsive Guidance Molecule b (RGMb) Is Dispensable for Normal Gonadal Function in Mice. Biol Reprod. 2016 Apr; 94(4):78. View in: Pubmed

      • Prevalence and predictors of androgen receptor and programmed death-ligand 1 in BRCA1-associated and sporadic triple-negative breast cancer. NPJ Breast Cancer. 2016; 2:16002. View in: Pubmed

      • Adaptive resistance to therapeutic PD-1 blockade is associated with upregulation of alternative immune checkpoints. Nat Commun. 2016 Feb 17; 7:10501. View in: Pubmed

      • Immunogenic Chemotherapy Sensitizes Tumors to Checkpoint Blockade Therapy. Immunity. 2016 Feb 16; 44(2):343-54. View in: Pubmed

      • STK11/LKB1 Deficiency Promotes Neutrophil Recruitment and Proinflammatory Cytokine Production to Suppress T-cell Activity in the Lung Tumor Microenvironment. Cancer Res. 2016 Mar 01; 76(5):999-1008. View in: Pubmed

      • LLT1 and CD161 Expression in Human Germinal Centers Promotes B Cell Activation and CXCR4 Downregulation. J Immunol. 2016 Mar 01; 196(5):2085-94. View in: Pubmed

      • Blockade of Tim-1 and Tim-4 Enhances Atherosclerosis in Low-Density Lipoprotein Receptor-Deficient Mice. Arterioscler Thromb Vasc Biol. 2016 Mar; 36(3):456-65. View in: Pubmed

      • Targetable genetic features of primary testicular and primary central nervous system lymphomas. Blood. 2016 Feb 18; 127(7):869-81. View in: Pubmed

      • Identification of the Cell-Intrinsic and -Extrinsic Pathways Downstream of EGFR and IFN? That Induce PD-L1 Expression in Head and Neck Cancer. Cancer Res. 2016 Mar 01; 76(5):1031-43. View in: Pubmed

      • Expression of PD-1 and Its Ligands, PD-L1 and PD-L2, in Smokers and Never Smokers with KRAS-Mutant Lung Cancer. J Thorac Oncol. 2015 Dec; 10(12):1726-35. View in: Pubmed

      • Glioblastoma Eradication Following Immune Checkpoint Blockade in an Orthotopic, Immunocompetent Model. Cancer Immunol Res. 2016 Feb; 4(2):124-35. View in: Pubmed

      • PD-L1 Antibodies to Its Cytoplasmic Domain Most Clearly Delineate Cell Membranes in Immunohistochemical Staining of Tumor Cells. Cancer Immunol Res. 2015 Dec; 3(12):1308-15. View in: Pubmed

      • MicroRNA MIR21 and T Cells in Colorectal Cancer. Cancer Immunol Res. 2016 Jan; 4(1):33-40. View in: Pubmed

      • Deletion of CTLA-4 on regulatory T cells during adulthood leads to resistance to autoimmunity. J Exp Med. 2015 Sep 21; 212(10):1603-21. View in: Pubmed

      • Fusobacterium nucleatum in colorectal carcinoma tissue and patient prognosis. Gut. 2016 12; 65(12):1973-1980. View in: Pubmed

      • BTLA expression declines on B cells of the aged and is associated with low responsiveness to the trivalent influenza vaccine. Oncotarget. 2015 Aug 14; 6(23):19445-55. View in: Pubmed

      • Fusobacterium nucleatum and T Cells in Colorectal Carcinoma. JAMA Oncol. 2015 Aug; 1(5):653-61. View in: Pubmed

      • Combination cancer immunotherapy and new immunomodulatory targets. Nat Rev Drug Discov. 2015 Aug; 14(8):561-84. View in: Pubmed

      • Defective TFH Cell Function and Increased TFR Cells Contribute to Defective Antibody Production in Aging. Cell Rep. 2015 Jul 14; 12(2):163-71. View in: Pubmed

      • Epithelial PD-L2 Expression Marks Barrett's Esophagus and Esophageal Adenocarcinoma. Cancer Immunol Res. 2015 Oct; 3(10):1123-1129. View in: Pubmed

      • Differential Expression of PD-L1 between Primary and Metastatic Sites in Clear-Cell Renal Cell Carcinoma. Cancer Immunol Res. 2015 Oct; 3(10):1158-64. View in: Pubmed

      • A New B7:CD28 Family Checkpoint Target for Cancer Immunotherapy: HHLA2. Clin Cancer Res. 2015 May 15; 21(10):2201-3. View in: Pubmed

      • The Next Immune-Checkpoint Inhibitors: PD-1/PD-L1 Blockade in Melanoma. Clin Ther. 2015 Apr 01; 37(4):764-82. View in: Pubmed

      • PD-1 alters T-cell metabolic reprogramming by inhibiting glycolysis and promoting lipolysis and fatty acid oxidation. Nat Commun. 2015 Mar 26; 6:6692. View in: Pubmed

      • B7-H3 expression in donor T cells and host cells negatively regulates acute graft-versus-host disease lethality. Blood. 2015 05 21; 125(21):3335-46. View in: Pubmed

      • Biologic Activity of Autologous, Granulocyte-Macrophage Colony-Stimulating Factor Secreting Alveolar Soft-Part Sarcoma and Clear Cell Sarcoma Vaccines. Clin Cancer Res. 2015 Jul 15; 21(14):3178-86. View in: Pubmed

      • Increased expression of the immune modulatory molecule PD-L1 (CD274) in anaplastic meningioma. Oncotarget. 2015 Mar 10; 6(7):4704-16. View in: Pubmed

      • ICOS:ICOS-ligand interaction is required for type 2 innate lymphoid cell function, homeostasis, and induction of airway hyperreactivity. Immunity. 2015 Mar 17; 42(3):538-51. View in: Pubmed

      • Interferon-?-induced activation of JAK1 and JAK2 suppresses tumor cell susceptibility to NK cells through upregulation of PD-L1 expression. Oncoimmunology. 2015 Jun; 4(6):e1008824. View in: Pubmed

      • Programmed death ligand-1 expression in adrenocortical carcinoma: an exploratory biomarker study. J Immunother Cancer. 2015; 3:3. View in: Pubmed

      • Orchestration and Prognostic Significance of Immune Checkpoints in the Microenvironment of Primary and Metastatic Renal Cell Cancer. Clin Cancer Res. 2015 Jul 01; 21(13):3031-40. View in: Pubmed

      • Novel roles of c-Met in the survival of renal cancer cells through the regulation of HO-1 and PD-L1 expression. J Biol Chem. 2015 Mar 27; 290(13):8110-20. View in: Pubmed

      • Nef promotes evasion of human immunodeficiency virus type 1-infected cells from the CTLA-4-mediated inhibition of T-cell activation. J Gen Virol. 2015 Jun; 96(Pt 6):1463-1477. View in: Pubmed

      • The microsatellite instable subset of colorectal cancer is a particularly good candidate for checkpoint blockade immunotherapy. Cancer Discov. 2015 Jan; 5(1):16-8. View in: Pubmed

      • PD-1 blockade with nivolumab in relapsed or refractory Hodgkin's lymphoma. N Engl J Med. 2015 Jan 22; 372(4):311-9. View in: Pubmed

      • Expression of programmed cell death 1 ligand 2 (PD-L2) is a distinguishing feature of primary mediastinal (thymic) large B-cell lymphoma and associated with PDCD1LG2 copy gain. Am J Surg Pathol. 2014 Dec; 38(12):1715-23. View in: Pubmed

      • Checkpoint blockade cancer immunotherapy targets tumour-specific mutant antigens. Nature. 2014 Nov 27; 515(7528):577-81. View in: Pubmed

      • OX40- and CD27-mediated costimulation synergizes with anti-PD-L1 blockade by forcing exhausted CD8+ T cells to exit quiescence. J Immunol. 2015 Jan 01; 194(1):125-133. View in: Pubmed

      • CD161 defines a transcriptional and functional phenotype across distinct human T cell lineages. Cell Rep. 2014 Nov 06; 9(3):1075-88. View in: Pubmed

      • Immunotherapy advances for glioblastoma. Neuro Oncol. 2014 Nov; 16(11):1441-58. View in: Pubmed

      • Interplay between regulatory T cells and PD-1 in modulating T cell exhaustion and viral control during chronic LCMV infection. J Exp Med. 2014 Aug 25; 211(9):1905-18. View in: Pubmed

      • Comment on "Tim-3 directly enhances CD8 T cell responses to acute Listeria monocytogenes infection". J Immunol. 2014 Jul 15; 193(2):467. View in: Pubmed

      • Immune checkpoint blockade for glioblastoma: preclinical activity of single agent and combinatorial therapy. Neuro Oncol. 2014 Jul; 16 Suppl 3:iii11-iii12. View in: Pubmed

      • Increased T follicular helper cells and germinal center B cells are required for cGVHD and bronchiolitis obliterans. Blood. 2014 Jun 19; 123(25):3988-98. View in: Pubmed

      • Loss of Lkb1 and Pten leads to lung squamous cell carcinoma with elevated PD-L1 expression. Cancer Cell. 2014 May 12; 25(5):590-604. View in: Pubmed

      • Response to BRAF inhibition in melanoma is enhanced when combined with immune checkpoint blockade. Cancer Immunol Res. 2014 Jul; 2(7):643-54. View in: Pubmed

      • RGMb is a novel binding partner for PD-L2 and its engagement with PD-L2 promotes respiratory tolerance. J Exp Med. 2014 May 05; 211(5):943-59. View in: Pubmed

      • Inclusion of CD80 in HSV targets the recombinant virus to PD-L1 on DCs and allows productive infection and robust immune responses. PLoS One. 2014; 9(1):e87617. View in: Pubmed

      • Dual blockade of PD-1 and CTLA-4 combined with tumor vaccine effectively restores T-cell rejection function in tumors--response. Cancer Res. 2014 Jan 15; 74(2):633-4; discussion 635. View in: Pubmed

      • Differential impact of PD-1 and/or interleukin-10 blockade on HIV-1-specific CD4 T cell and antigen-presenting cell functions. J Virol. 2014 Mar; 88(5):2508-18. View in: Pubmed

      • PD-1 blockade in chronically HIV-1-infected humanized mice suppresses viral loads. PLoS One. 2013; 8(10):e77780. View in: Pubmed

      • Liver environment and HCV replication affect human T-cell phenotype and expression of inhibitory receptors. Gastroenterology. 2014 Feb; 146(2):550-61. View in: Pubmed

      • Activation of the PD-1 pathway contributes to immune escape in EGFR-driven lung tumors. Cancer Discov. 2013 Dec; 3(12):1355-63. View in: Pubmed

      • Host programmed death ligand 1 is dominant over programmed death ligand 2 expression in regulating graft-versus-host disease lethality. Blood. 2013 Oct 24; 122(17):3062-73. View in: Pubmed

      • DEC-205-mediated antigen targeting to steady-state dendritic cells induces deletion of diabetogenic CD8? T cells independently of PD-1 and PD-L1. Int Immunol. 2013 Nov; 25(11):651-60. View in: Pubmed

      • Immunotherapy of chronic hepatitis C virus infection with antibodies against programmed cell death-1 (PD-1). Proc Natl Acad Sci U S A. 2013 Sep 10; 110(37):15001-6. View in: Pubmed

      • Therapeutic PD-1 pathway blockade augments with other modalities of immunotherapy T-cell function to prevent immune decline in ovarian cancer. Cancer Res. 2013 Dec 01; 73(23):6900-12. View in: Pubmed

      • Costimulatory genes: hotspots of conflict between host defense and autoimmunity. Immunity. 2013 Jun 27; 38(6):1083-5. View in: Pubmed

      • An update on vaccine therapy and other immunotherapeutic approaches for glioblastoma. Expert Rev Vaccines. 2013 Jun; 12(6):597-615. View in: Pubmed

      • PD-L1 blockade synergizes with IL-2 therapy in reinvigorating exhausted T cells. J Clin Invest. 2013 Jun; 123(6):2604-15. View in: Pubmed

      • PD-L1 expression is characteristic of a subset of aggressive B-cell lymphomas and virus-associated malignancies. Clin Cancer Res. 2013 Jul 01; 19(13):3462-73. View in: Pubmed

      • T-cell immunoglobulin and mucin domain 1 deficiency eliminates airway hyperreactivity triggered by the recognition of airway cell death. J Allergy Clin Immunol. 2013 Aug; 132(2):414-25.e6. View in: Pubmed

      • Dual blockade of PD-1 and CTLA-4 combined with tumor vaccine effectively restores T-cell rejection function in tumors. Cancer Res. 2013 Jun 15; 73(12):3591-603. View in: Pubmed

      • Strength of PD-1 signaling differentially affects T-cell effector functions. Proc Natl Acad Sci U S A. 2013 Jul 02; 110(27):E2480-9. View in: Pubmed

      • CD160Ig fusion protein targets a novel costimulatory pathway and prolongs allograft survival. PLoS One. 2013; 8(4):e60391. View in: Pubmed

      • TIM-family proteins promote infection of multiple enveloped viruses through virion-associated phosphatidylserine. PLoS Pathog. 2013 Mar; 9(3):e1003232. View in: Pubmed

      • Inadequate T follicular cell help impairs B cell immunity during HIV infection. Nat Med. 2013 Apr; 19(4):494-9. View in: Pubmed

      • Increased T-bet is associated with senescence of influenza virus-specific CD8 T cells in aged humans. J Leukoc Biol. 2013 Jun; 93(6):825-36. View in: Pubmed

      • Down-regulation of CTLA-4 by HIV-1 Nef protein. PLoS One. 2013; 8(1):e54295. View in: Pubmed

      • TIM-4, expressed by medullary macrophages, regulates respiratory tolerance by mediating phagocytosis of antigen-specific T cells. Mucosal Immunol. 2013 May; 6(3):580-90. View in: Pubmed

      • Cell-intrinsic abrogation of TGF-ß signaling delays but does not prevent dysfunction of self/tumor-specific CD8 T cells in a murine model of autochthonous prostate cancer. J Immunol. 2012 Oct 15; 189(8):3936-46. View in: Pubmed

      • Intact B7-H3 signaling promotes allograft prolongation through preferential suppression of Th1 effector responses. Eur J Immunol. 2012 Sep; 42(9):2343-53. View in: Pubmed

      • CD40L-Tri, a novel formulation of recombinant human CD40L that effectively activates B cells. Cancer Immunol Immunother. 2013 Feb; 62(2):347-57. View in: Pubmed

      • PD-1 blockade during chronic SIV infection reduces hyperimmune activation and microbial translocation in rhesus macaques. J Clin Invest. 2012 May; 122(5):1712-6. View in: Pubmed

      • Binding of hepatitis A virus to its cellular receptor 1 inhibits T-regulatory cell functions in humans. Gastroenterology. 2012 Jun; 142(7):1516-25.e3. View in: Pubmed

      • Immune surveillance and therapy of lymphomas driven by Epstein-Barr virus protein LMP1 in a mouse model. Cell. 2012 Feb 17; 148(4):739-51. View in: Pubmed

      • A new therapeutic strategy for malaria: targeting T cell exhaustion. Nat Immunol. 2012 Jan 19; 13(2):113-5. View in: Pubmed

      • Antigen-specific CD4 T-cell help rescues exhausted CD8 T cells during chronic viral infection. Proc Natl Acad Sci U S A. 2011 Dec 27; 108(52):21182-7. View in: Pubmed

      • Pillars article: CTLA-4 can function as a negative regulator of T cell activation. Immunity. 1994. 1: 405-413. J Immunol. 2011 Oct 01; 187(7):3466-74. View in: Pubmed

      • Tight regulation of memory CD8(+) T cells limits their effectiveness during sustained high viral load. Immunity. 2011 Aug 26; 35(2):285-98. View in: Pubmed

      • 4-1BB signaling synergizes with programmed death ligand 1 blockade to augment CD8 T cell responses during chronic viral infection. J Immunol. 2011 Aug 15; 187(4):1634-42. View in: Pubmed

      • The programmed death-1 ligand 1:B7-1 pathway restrains diabetogenic effector T cells in vivo. J Immunol. 2011 Aug 01; 187(3):1097-105. View in: Pubmed

      • The novel costimulatory programmed death ligand 1/B7.1 pathway is functional in inhibiting alloimmune responses in vivo. J Immunol. 2011 Aug 01; 187(3):1113-9. View in: Pubmed

      • Responsiveness of HIV-specific CD4 T cells to PD-1 blockade. Blood. 2011 Jul 28; 118(4):965-74. View in: Pubmed

      • Impairment of the programmed cell death-1 pathway increases atherosclerotic lesion development and inflammation. Arterioscler Thromb Vasc Biol. 2011 May; 31(5):1100-7. View in: Pubmed

      • Phenotype, function, and gene expression profiles of programmed death-1(hi) CD8 T cells in healthy human adults. J Immunol. 2011 Apr 01; 186(7):4200-12. View in: Pubmed

      • A polymorphism in TIM1 is associated with susceptibility to severe hepatitis A virus infection in humans. J Clin Invest. 2011 Mar; 121(3):1111-8. View in: Pubmed

      • The role of LAT in increased CD8+ T cell exhaustion in trigeminal ganglia of mice latently infected with herpes simplex virus 1. J Virol. 2011 May; 85(9):4184-97. View in: Pubmed

      • Expression of PD-L1 and PD-L2 on human macrophages is up-regulated by HIV-1 and differentially modulated by IL-10. J Leukoc Biol. 2011 Apr; 89(4):507-15. View in: Pubmed

      • TIM-4, a receptor for phosphatidylserine, controls adaptive immunity by regulating the removal of antigen-specific T cells. J Immunol. 2010 Dec 01; 185(11):6839-49. View in: Pubmed

      • Acute depletion of activated memory B cells involves the PD-1 pathway in rapidly progressing SIV-infected macaques. J Clin Invest. 2010 Nov; 120(11):3878-90. View in: Pubmed

      • Nonhematopoietic antigen blocks memory programming of alloreactive CD8+ T cells and drives their eventual exhaustion in mouse models of bone marrow transplantation. J Clin Invest. 2010 Nov; 120(11):3855-68. View in: Pubmed

      • Transcriptional analysis of HIV-specific CD8+ T cells shows that PD-1 inhibits T cell function by upregulating BATF. Nat Med. 2010 Oct; 16(10):1147-51. View in: Pubmed

      • Apoptotic cells activate NKT cells through T cell Ig-like mucin-like-1 resulting in airway hyperreactivity. J Immunol. 2010 Nov 01; 185(9):5225-35. View in: Pubmed

      • Cooperation of Tim-3 and PD-1 in CD8 T-cell exhaustion during chronic viral infection. Proc Natl Acad Sci U S A. 2010 Aug 17; 107(33):14733-8. View in: Pubmed

      • The phosphatidylserine receptors, T cell immunoglobulin mucin proteins 3 and 4, are markers of histiocytic sarcoma and other histiocytic and dendritic cell neoplasms. Hum Pathol. 2010 Oct; 41(10):1486-94. View in: Pubmed

      • PD-1 on immature and PD-1 ligands on migratory human Langerhans cells regulate antigen-presenting cell activity. J Invest Dermatol. 2010 Sep; 130(9):2222-30. View in: Pubmed

      • TIM genes: a family of cell surface phosphatidylserine receptors that regulate innate and adaptive immunity. Immunol Rev. 2010 May; 235(1):172-89. View in: Pubmed

      • Role of PD-1 in regulating acute infections. Curr Opin Immunol. 2010 Jun; 22(3):397-401. View in: Pubmed

      • T cell/transmembrane, Ig, and mucin-3 allelic variants differentially recognize phosphatidylserine and mediate phagocytosis of apoptotic cells. J Immunol. 2010 Feb 15; 184(4):1918-30. View in: Pubmed

      • Regulation of T-cell chemotaxis by programmed death-ligand 1 (PD-L1) in dry eye-associated corneal inflammation. Invest Ophthalmol Vis Sci. 2010 Jul; 51(7):3418-23. View in: Pubmed

      • Dual control of antitumor CD8 T cells through the programmed death-1/programmed death-ligand 1 pathway and immunosuppressive CD4 T cells: regulation and counterregulation. J Immunol. 2009 Dec 15; 183(12):7898-908. View in: Pubmed

      • PD-L1 regulates the development, maintenance, and function of induced regulatory T cells. J Exp Med. 2009 Dec 21; 206(13):3015-29. View in: Pubmed

      • Tissue-specific differences in PD-1 and PD-L1 expression during chronic viral infection: implications for CD8 T-cell exhaustion. J Virol. 2010 Feb; 84(4):2078-89. View in: Pubmed

      • Inhibitory TCR coreceptor PD-1 is a sensitive indicator of low-level replication of SIV and HIV-1. J Immunol. 2010 Jan 01; 184(1):476-87. View in: Pubmed

      • Upregulation of interleukin 7 receptor alpha and programmed death 1 marks an epitope-specific CD8+ T-cell response that disappears following primary Epstein-Barr virus infection. J Virol. 2009 Sep; 83(18):9068-78. View in: Pubmed

      • Targeting Tim-1 to overcome resistance to transplantation tolerance mediated by CD8 T17 cells. Proc Natl Acad Sci U S A. 2009 Jun 30; 106(26):10734-9. View in: Pubmed

      • Induction of robust cellular and humoral virus-specific adaptive immune responses in human immunodeficiency virus-infected humanized BLT mice. J Virol. 2009 Jul; 83(14):7305-21. View in: Pubmed

      • Role of the immune modulator programmed cell death-1 during development and apoptosis of mouse retinal ganglion cells. Invest Ophthalmol Vis Sci. 2009 Oct; 50(10):4941-8. View in: Pubmed

      • The CD160, BTLA, LIGHT/HVEM pathway: a bidirectional switch regulating T-cell activation. Immunol Rev. 2009 May; 229(1):244-58. View in: Pubmed

      • Synergistic reversal of intrahepatic HCV-specific CD8 T cell exhaustion by combined PD-1/CTLA-4 blockade. PLoS Pathog. 2009 Feb; 5(2):e1000313. View in: Pubmed

      • Intestinal tolerance is converted to autoimmune enteritis upon PD-1 ligand blockade. J Immunol. 2009 Feb 15; 182(4):2102-12. View in: Pubmed

      • Constitutive neuronal expression of the immune regulator, programmed death 1 (PD-1), identified during experimental autoimmune uveitis. Ocul Immunol Inflamm. 2009 Jan-Feb; 17(1):47-55. View in: Pubmed

      • IL-10 and PD-L1 operate through distinct pathways to suppress T-cell activity during persistent viral infection. Proc Natl Acad Sci U S A. 2008 Dec 23; 105(51):20428-33. View in: Pubmed

      • Enhancing SIV-specific immunity in vivo by PD-1 blockade. Nature. 2009 Mar 12; 458(7235):206-10. View in: Pubmed

      • Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection. Nat Immunol. 2009 Jan; 10(1):29-37. View in: Pubmed

      • Simian immunodeficiency virus (SIV)-specific CD8+ T-cell responses in vervet African green monkeys chronically infected with SIVagm. J Virol. 2008 Dec; 82(23):11577-88. View in: Pubmed

      • Selective expansion of a subset of exhausted CD8 T cells by alphaPD-L1 blockade. Proc Natl Acad Sci U S A. 2008 Sep 30; 105(39):15016-21. View in: Pubmed

      • Telomerase activity of HIV-1-specific CD8+ T cells: constitutive up-regulation in controllers and selective increase by blockade of PD ligand 1 in progressors. Blood. 2008 Nov 01; 112(9):3679-87. View in: Pubmed

      • Impaired hepatitis C virus (HCV)-specific effector CD8+ T cells undergo massive apoptosis in the peripheral blood during acute HCV infection and in the liver during the chronic phase of infection. J Virol. 2008 Oct; 82(20):9808-22. View in: Pubmed

      • Structures of PD-1 with its ligands: sideways and dancing cheek to cheek. Proc Natl Acad Sci U S A. 2008 Jul 29; 105(30):10275-6. View in: Pubmed

      • Interaction of human PD-L1 and B7-1. Mol Immunol. 2008 Aug; 45(13):3567-72. View in: Pubmed

      • Peripheral deletional tolerance of alloreactive CD8 but not CD4 T cells is dependent on the PD-1/PD-L1 pathway. Blood. 2008 Sep 01; 112(5):2149-55. View in: Pubmed

      • Transient blockade of the inducible costimulator pathway generates long-term tolerance to factor VIII after nonviral gene transfer into hemophilia A mice. Blood. 2008 Sep 01; 112(5):1662-72. View in: Pubmed

      • ICOS/ICOSL interaction is required for CD4+ invariant NKT cell function and homeostatic survival. J Immunol. 2008 Apr 15; 180(8):5448-56. View in: Pubmed

      • Variable patterns of programmed death-1 expression on fully functional memory T cells after spontaneous resolution of hepatitis C virus infection. J Virol. 2008 May; 82(10):5109-14. View in: Pubmed

      • Enhancing therapeutic vaccination by blocking PD-1-mediated inhibitory signals during chronic infection. J Exp Med. 2008 Mar 17; 205(3):543-55. View in: Pubmed

      • Functional restoration of HCV-specific CD8 T cells by PD-1 blockade is defined by PD-1 expression and compartmentalization. Gastroenterology. 2008 Jun; 134(7):1927-37, 1937.e1-2. View in: Pubmed

      • The PD-1/PD-L costimulatory pathway critically affects host resistance to the pathogenic fungus Histoplasma capsulatum. Proc Natl Acad Sci U S A. 2008 Feb 19; 105(7):2658-63. View in: Pubmed

      • CD160 inhibits activation of human CD4+ T cells through interaction with herpesvirus entry mediator. Nat Immunol. 2008 Feb; 9(2):176-85. View in: Pubmed

      • TIM gene family and their role in atopic diseases. Curr Top Microbiol Immunol. 2008; 321:201-15. View in: Pubmed

      • PD-1 and its ligands in tolerance and immunity. Annu Rev Immunol. 2008; 26:677-704. View in: Pubmed

      • High level of PD-1 expression on hepatitis C virus (HCV)-specific CD8+ and CD4+ T cells during acute HCV infection, irrespective of clinical outcome. J Virol. 2008 Mar; 82(6):3154-60. View in: Pubmed

      • Structures of T cell immunoglobulin mucin protein 4 show a metal-Ion-dependent ligand binding site where phosphatidylserine binds. Immunity. 2007 Dec; 27(6):941-51. View in: Pubmed

      • TIM-1 and TIM-4 glycoproteins bind phosphatidylserine and mediate uptake of apoptotic cells. Immunity. 2007 Dec; 27(6):927-40. View in: Pubmed

      • Endothelial programmed death-1 ligand 1 (PD-L1) regulates CD8+ T-cell mediated injury in the heart. Circulation. 2007 Oct 30; 116(18):2062-71. View in: Pubmed

      • PD-1 regulates self-reactive CD8+ T cell responses to antigen in lymph nodes and tissues. J Immunol. 2007 Oct 15; 179(8):5064-70. View in: Pubmed

      • PD-1 expression on human CD8 T cells depends on both state of differentiation and activation status. AIDS. 2007 Oct 01; 21(15):2005-13. View in: Pubmed

      • Upregulation of CTLA-4 by HIV-specific CD4+ T cells correlates with disease progression and defines a reversible immune dysfunction. Nat Immunol. 2007 Nov; 8(11):1246-54. View in: Pubmed

      • Role of ICOS pathway in autoimmune and alloimmune responses in NOD mice. Clin Immunol. 2008 Feb; 126(2):140-7. View in: Pubmed

      • Viral targeting of fibroblastic reticular cells contributes to immunosuppression and persistence during chronic infection. Proc Natl Acad Sci U S A. 2007 Sep 25; 104(39):15430-5. View in: Pubmed

      • The function of donor versus recipient programmed death-ligand 1 in corneal allograft survival. J Immunol. 2007 Sep 15; 179(6):3672-9. View in: Pubmed

      • In-fusion assembly: seamless engineering of multidomain fusion proteins, modular vectors, and mutations. Biotechniques. 2007 Sep; 43(3):354-9. View in: Pubmed

      • A novel alloantigen-specific CD8+PD1+ regulatory T cell induced by ICOS-B7h blockade in vivo. J Immunol. 2007 Jul 15; 179(2):786-96. View in: Pubmed

      • Programmed death-1 ligand 1 interacts specifically with the B7-1 costimulatory molecule to inhibit T cell responses. Immunity. 2007 Jul; 27(1):111-22. View in: Pubmed

      • Twisted gastrulation (Tsg) is regulated by Tob and enhances TGF-beta signaling in activated T lymphocytes. Blood. 2007 Apr 01; 109(7):2944-52. View in: Pubmed

      • Elevated expression levels of inhibitory receptor programmed death 1 on simian immunodeficiency virus-specific CD8 T cells during chronic infection but not after vaccination. J Virol. 2007 Jun; 81(11):5819-28. View in: Pubmed

      • The function of programmed cell death 1 and its ligands in regulating autoimmunity and infection. Nat Immunol. 2007 Mar; 8(3):239-45. View in: Pubmed

      • PD-1:PD-L1 interactions contribute to the functional suppression of virus-specific CD8+ T lymphocytes in the liver. J Immunol. 2007 Mar 01; 178(5):2714-20. View in: Pubmed

      • Immunoglobulin A (IgA) is a natural ligand of hepatitis A virus cellular receptor 1 (HAVCR1), and the association of IgA with HAVCR1 enhances virus-receptor interactions. J Virol. 2007 Apr; 81(7):3437-46. View in: Pubmed

      • Liver-infiltrating lymphocytes in chronic human hepatitis C virus infection display an exhausted phenotype with high levels of PD-1 and low levels of CD127 expression. J Virol. 2007 Mar; 81(6):2545-53. View in: Pubmed

      • Reinvigorating exhausted HIV-specific T cells via PD-1-PD-1 ligand blockade. J Exp Med. 2006 Oct 02; 203(10):2223-7. View in: Pubmed

      • Innate immunity in multiple sclerosis: myeloid dendritic cells in secondary progressive multiple sclerosis are activated and drive a proinflammatory immune response. J Immunol. 2006 Sep 15; 177(6):4196-202. View in: Pubmed

      • PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression. Nature. 2006 Sep 21; 443(7109):350-4. View in: Pubmed

      • Programmed death-1 (PD-1) is a marker of germinal center-associated T cells and angioimmunoblastic T-cell lymphoma. Am J Surg Pathol. 2006 Jul; 30(7):802-10. View in: Pubmed

      • Tyk2 negatively regulates adaptive Th1 immunity by mediating IL-10 signaling and promoting IFN-gamma-dependent IL-10 reactivation. J Immunol. 2006 Jun 15; 176(12):7263-71. View in: Pubmed

      • Tissue expression of PD-L1 mediates peripheral T cell tolerance. J Exp Med. 2006 Apr 17; 203(4):883-95. View in: Pubmed

      • The ICOS-ligand B7-H2, expressed on human type II alveolar epithelial cells, plays a role in the pulmonary host defense system. Eur J Immunol. 2006 Apr; 36(4):906-18. View in: Pubmed

      • PD-L1 and PD-L2 have distinct roles in regulating host immunity to cutaneous leishmaniasis. Eur J Immunol. 2006 Jan; 36(1):58-64. View in: Pubmed

      • Restoring function in exhausted CD8 T cells during chronic viral infection. Nature. 2006 Feb 09; 439(7077):682-7. View in: Pubmed

      • Programmed death-1 (PD-1):PD-ligand 1 interactions inhibit TCR-mediated positive selection of thymocytes. J Immunol. 2005 Dec 01; 175(11):7372-9. View in: Pubmed

      • Engagement of CD83 ligand induces prolonged expansion of CD8+ T cells and preferential enrichment for antigen specificity. Blood. 2006 Feb 15; 107(4):1528-36. View in: Pubmed

      • Rap1-GTP is a negative regulator of Th cell function and promotes the generation of CD4+CD103+ regulatory T cells in vivo. J Immunol. 2005 Sep 01; 175(5):3133-9. View in: Pubmed

      • CD226 is specifically expressed on the surface of Th1 cells and regulates their expansion and effector functions. J Immunol. 2005 Aug 01; 175(3):1558-65. View in: Pubmed

      • TIM-1 induces T cell activation and inhibits the development of peripheral tolerance. Nat Immunol. 2005 May; 6(5):447-54. View in: Pubmed

      • The B7 family revisited. Annu Rev Immunol. 2005; 23:515-48. View in: Pubmed

      • Targeting of inducible costimulator (ICOS) expressed on alloreactive T cells down-regulates graft-versus-host disease (GVHD) and facilitates engraftment of allogeneic bone marrow (BM). Blood. 2005 Apr 15; 105(8):3372-80. View in: Pubmed

      • RIAM, an Ena/VASP and Profilin ligand, interacts with Rap1-GTP and mediates Rap1-induced adhesion. Dev Cell. 2004 Oct; 7(4):585-95. View in: Pubmed

      • Induction of T helper type 1-like regulatory cells that express Foxp3 and protect against airway hyper-reactivity. Nat Immunol. 2004 Nov; 5(11):1149-56. View in: Pubmed

      • PD-1 ligands, negative regulators for activation of naive, memory, and recently activated human CD4+ T cells. Cell Immunol. 2004 Aug; 230(2):89-98. View in: Pubmed

      • PD-L1-deficient mice show that PD-L1 on T cells, antigen-presenting cells, and host tissues negatively regulates T cells. Proc Natl Acad Sci U S A. 2004 Jul 20; 101(29):10691-6. View in: Pubmed

      • CD4+CD25+ T regulatory cells dependent on ICOS promote regulation of effector cells in the prediabetic lesion. J Exp Med. 2004 Jun 07; 199(11):1479-89. View in: Pubmed

      • An autoimmune disease-associated CTLA-4 splice variant lacking the B7 binding domain signals negatively in T cells. Immunity. 2004 May; 20(5):563-75. View in: Pubmed

      • Endothelial expression of PD-L1 and PD-L2 down-regulates CD8+ T cell activation and cytolysis. Eur J Immunol. 2003 Nov; 33(11):3117-26. View in: Pubmed

      • Interaction of Tim-3 and Tim-3 ligand regulates T helper type 1 responses and induction of peripheral tolerance. Nat Immunol. 2003 Nov; 4(11):1102-10. View in: Pubmed

      • Immunology: hepatitis A virus link to atopic disease. Nature. 2003 Oct 09; 425(6958):576. View in: Pubmed

      • Regulation of PD-1, PD-L1, and PD-L2 expression during normal and autoimmune responses. Eur J Immunol. 2003 Oct; 33(10):2706-16. View in: Pubmed

      • The role of the ICOS-B7h T cell costimulatory pathway in transplantation immunity. J Clin Invest. 2003 Jul; 112(2):234-43. View in: Pubmed

      • The TIM gene family: emerging roles in immunity and disease. Nat Rev Immunol. 2003 Jun; 3(6):454-62. View in: Pubmed

      • The BAL-binding protein BBAP and related Deltex family members exhibit ubiquitin-protein isopeptide ligase activity. J Biol Chem. 2003 Jun 13; 278(24):21930-7. View in: Pubmed

      • Blockade of programmed death-1 ligands on dendritic cells enhances T cell activation and cytokine production. J Immunol. 2003 Feb 01; 170(3):1257-66. View in: Pubmed

      • CD4+CD25+ regulatory cells from human peripheral blood express very high levels of CD25 ex vivo. Novartis Found Symp. 2003; 252:67-88; discussion 88-91, 106-14. View in: Pubmed

      • Cutting edge: CD94/NKG2 is expressed on Th1 but not Th2 cells and costimulates Th1 effector functions. J Immunol. 2002 Nov 15; 169(10):5382-6. View in: Pubmed

      • Differential expression of PD-L1 and PD-L2, ligands for an inhibitory receptor PD-1, in the cells of lymphohematopoietic tissues. Immunol Lett. 2002 Oct 21; 84(1):57-62. View in: Pubmed

      • Protect the killer: CTLs need defenses against the tumor. Nat Med. 2002 Aug; 8(8):787-9. View in: Pubmed

      • Antigen-specific regulatory T cells develop via the ICOS-ICOS-ligand pathway and inhibit allergen-induced airway hyperreactivity. Nat Med. 2002 Sep; 8(9):1024-32. View in: Pubmed

      • Critical role of CD81 in cognate T-B cell interactions leading to Th2 responses. Int Immunol. 2002 May; 14(5):513-23. View in: Pubmed

      • Expression and regulation of the PD-L1 immunoinhibitory molecule on microvascular endothelial cells. Microcirculation. 2002 Apr; 9(2):133-45. View in: Pubmed

      • PD-1:PD-L inhibitory pathway affects both CD4(+) and CD8(+) T cells and is overcome by IL-2. Eur J Immunol. 2002 03; 32(3):634-43. View in: Pubmed

      • The B7-CD28 superfamily. Nat Rev Immunol. 2002 Feb; 2(2):116-26. View in: Pubmed

      • Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease. Nature. 2002 Jan 31; 415(6871):536-41. View in: Pubmed

      • Tob is a negative regulator of activation that is expressed in anergic and quiescent T cells. Nat Immunol. 2001 Dec; 2(12):1174-82. View in: Pubmed

      • Identification of Tapr (an airway hyperreactivity regulatory locus) and the linked Tim gene family. Nat Immunol. 2001 Dec; 2(12):1109-16. View in: Pubmed

      • Characterization of endogenous Chinese hamster ovary cell surface molecules that mediate T cell costimulation. Cell Immunol. 2001 Nov 01; 213(2):83-93. View in: Pubmed

      • CD4+CD25high regulatory cells in human peripheral blood. J Immunol. 2001 Aug 01; 167(3):1245-53. View in: Pubmed

      • Molecular cloning of Porimin, a novel cell surface receptor mediating oncotic cell death. Proc Natl Acad Sci U S A. 2001 Aug 14; 98(17):9778-83. View in: Pubmed

      • B7-dependent T-cell costimulation in mice lacking CD28 and CTLA4. J Clin Invest. 2001 Apr; 107(7):881-7. View in: Pubmed

      • PD-L2 is a second ligand for PD-1 and inhibits T cell activation. Nat Immunol. 2001 Mar; 2(3):261-8. View in: Pubmed

      • ICOS is critical for CD40-mediated antibody class switching. Nature. 2001 Jan 04; 409(6816):102-5. View in: Pubmed

      • Intercellular adhesion molecule 1 is critical for activation of CD28-deficient T cells. J Immunol. 2000 Dec 01; 165(11):6091-8. View in: Pubmed

      • Examination of CD8+ T cell function in humans using MHC class I tetramers: similar cytotoxicity but variable proliferation and cytokine production among different clonal CD8+ T cells specific to a single viral epitope. J Immunol. 2000 Dec 01; 165(11):6214-20. View in: Pubmed

      • Mouse inducible costimulatory molecule (ICOS) expression is enhanced by CD28 costimulation and regulates differentiation of CD4+ T cells. J Immunol. 2000 Nov 01; 165(9):5035-40. View in: Pubmed

      • Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation. J Exp Med. 2000 Oct 02; 192(7):1027-34. View in: Pubmed

      • Expression of MHC class II-associated invariant chain (Ii;CD74) in thymic epithelial neoplasms. Appl Immunohistochem Mol Morphol. 2000 Sep; 8(3):210-5. View in: Pubmed

      • p27kip1 functions as an anergy factor inhibiting interleukin 2 transcription and clonal expansion of alloreactive human and mouse helper T lymphocytes. Nat Med. 2000 Mar; 6(3):290-7. View in: Pubmed

      • Molecular characterisation of a NADH ubiquinone oxidoreductase subunit 5 from Schistosoma mansoni and inhibition of mitochondrial respiratory chain function by testosterone. Mol Cell Biochem. 1999 Dec; 202(1-2):149-58. View in: Pubmed

      • Ox40-ligand has a critical costimulatory role in dendritic cell:T cell interactions. Immunity. 1999 Dec; 11(6):689-98. View in: Pubmed

      • PTPROt: an alternatively spliced and developmentally regulated B-lymphoid phosphatase that promotes G0/G1 arrest. Blood. 1999 Oct 01; 94(7):2403-13. View in: Pubmed

      • Regulation of human intestinal intraepithelial lymphocyte cytolytic function by biliary glycoprotein (CD66a). J Immunol. 1999 Aug 01; 163(3):1363-70. View in: Pubmed

      • B7-2 expressed on EL4 lymphoma suppresses antitumor immunity by an interleukin 4-dependent mechanism. J Exp Med. 1999 Mar 15; 189(6):919-30. View in: Pubmed

      • Changes in the strength of co-stimulation through the B7/CD28 pathway alter functional T cell responses to altered peptide ligands. Int Immunol. 1999 Mar; 11(3):407-16. View in: Pubmed

      • CD48-deficient mice have a pronounced defect in CD4(+) T cell activation. Proc Natl Acad Sci U S A. 1999 Feb 02; 96(3):1019-23. View in: Pubmed

      • Cutting edge: MHC class I triggering by a novel cell surface ligand costimulates proliferation of activated human T cells. J Immunol. 1999 Feb 01; 162(3):1223-6. View in: Pubmed

      • Cloning of BY55, a novel Ig superfamily member expressed on NK cells, CTL, and intestinal intraepithelial lymphocytes. J Immunol. 1998 Sep 15; 161(6):2780-90. View in: Pubmed

      • The BB1 monoclonal antibody recognizes both cell surface CD74 (MHC class II-associated invariant chain) as well as B7-1 (CD80), resolving the question regarding a third CD28/CTLA-4 counterreceptor. J Immunol. 1998 Sep 15; 161(6):2708-15. View in: Pubmed

      • Attractin (DPPT-L), a member of the CUB family of cell adhesion and guidance proteins, is secreted by activated human T lymphocytes and modulates immune cell interactions. Proc Natl Acad Sci U S A. 1998 Sep 15; 95(19):11336-41. View in: Pubmed

      • The leukocyte semaphorin CD100 is expressed in most T-cell, but few B-cell, non-Hodgkin's lymphomas. Am J Pathol. 1998 Jul; 153(1):255-62. View in: Pubmed

      • Expansion of autoreactive T cells in multiple sclerosis is independent of exogenous B7 costimulation. J Immunol. 1998 Feb 01; 160(3):1532-8. View in: Pubmed

      • In vivo expression of B7-1 and B7-2 by follicular lymphoma cells can prevent induction of T-cell anergy but is insufficient to induce significant T-cell proliferation. Blood. 1997 Dec 01; 90(11):4297-306. View in: Pubmed

      • Expression of a hypoglycosylated form of CD86 (B7-2) on human T cells with altered binding properties to CD28 and CTLA-4. J Immunol. 1997 Nov 15; 159(10):4799-805. View in: Pubmed

      • Maintenance of human T cell anergy: blocking of IL-2 gene transcription by activated Rap1. Science. 1997 Oct 03; 278(5335):124-8. View in: Pubmed

      • Induction of T cell clonal anergy results in resistance, whereas CD28-mediated costimulation primes for susceptibility to Fas- and Bax-mediated programmed cell death. J Immunol. 1997 Oct 01; 159(7):3156-67. View in: Pubmed

      • Weak peptide agonists reveal functional differences in B7-1 and B7-2 costimulation of human T cell clones. J Immunol. 1997 Aug 15; 159(4):1669-75. View in: Pubmed

      • Ex vivo generation of human anti-pre-B leukemia-specific autologous cytolytic T cells. Blood. 1997 Jul 15; 90(2):549-61. View in: Pubmed

      • Role of the CD40 and CD95 (APO-1/Fas) antigens in the apoptosis of human B-cell malignancies. Br J Haematol. 1997 May; 97(2):409-17. View in: Pubmed

      • B7.2 expressed by T cells does not induce CD28-mediated costimulatory activity but retains CTLA4 binding: implications for induction of antitumor immunity to T cell tumors. J Immunol. 1997 Mar 01; 158(5):2025-34. View in: Pubmed

      • B7-1 and B7-2 have overlapping, critical roles in immunoglobulin class switching and germinal center formation. Immunity. 1997 Mar; 6(3):303-13. View in: Pubmed

      • Breast cancer-associated antigen, DF3/MUC1, induces apoptosis of activated human T cells. Nat Med. 1996 Dec; 2(12):1367-70. View in: Pubmed

      • Human CD100, a novel leukocyte semaphorin that promotes B-cell aggregation and differentiation. Proc Natl Acad Sci U S A. 1996 Oct 15; 93(21):11780-5. View in: Pubmed

      • Activation of human T cell lymphotropic virus type I-infected T cells is independent of B7 costimulation. J Immunol. 1996 Oct 01; 157(7):2932-8. View in: Pubmed

      • The role of B7-1/B7-2:CD28/CLTA-4 pathways in the prevention of anergy, induction of productive immunity and down-regulation of the immune response. Immunol Rev. 1996 Oct; 153:5-26. View in: Pubmed

      • Differential association of protein tyrosine kinases with the T cell receptor is linked to the induction of anergy and its prevention by B7 family-mediated costimulation. J Exp Med. 1996 Aug 01; 184(2):365-76. View in: Pubmed

      • Pre-B acute lymphoblastic leukemia cells may induce T-cell anergy to alloantigen. Blood. 1996 Jul 01; 88(1):41-8. View in: Pubmed

      • Complete blockade of B7 family-mediated costimulation is necessary to induce human alloantigen-specific anergy: a method to ameliorate graft-versus-host disease and extend the donor pool. Blood. 1996 Jun 01; 87(11):4887-93. View in: Pubmed

      • A cell type-specific enhancer in the human B7.1 gene regulated by NF-kappaB. J Exp Med. 1996 Mar 01; 183(3):777-89. View in: Pubmed

      • B7-1 is superior to B7-2 costimulation in the induction and maintenance of T cell-mediated antileukemia immunity. Further evidence that B7-1 and B7-2 are functionally distinct. J Immunol. 1996 Feb 01; 156(3):1126-31. View in: Pubmed

      • Differential expression of alternate mB7-2 transcripts. J Immunol. 1995 Dec 15; 155(12):5490-7. View in: Pubmed

      • Follicular lymphomas can be induced to present alloantigen efficiently: a conceptual model to improve their tumor immunogenicity. Proc Natl Acad Sci U S A. 1995 Aug 29; 92(18):8200-4. View in: Pubmed

      • Role of B7-1 in mediating an immune response to myeloid leukemia cells. Blood. 1995 May 01; 85(9):2507-15. View in: Pubmed

      • B7-1 and B7-2 do not deliver identical costimulatory signals, since B7-2 but not B7-1 preferentially costimulates the initial production of IL-4. Immunity. 1995 May; 2(5):523-32. View in: Pubmed

      • CD40 ligand triggered interleukin-6 secretion in multiple myeloma. Blood. 1995 Apr 01; 85(7):1903-12. View in: Pubmed

      • The critical role of CD28 signalling in the prevention of human T-cell anergy. Res Immunol. 1995 Mar-Apr; 146(3):140-9. View in: Pubmed

      • CTLA4 mediates antigen-specific apoptosis of human T cells. Proc Natl Acad Sci U S A. 1995 Jan 31; 92(3):811-5. View in: Pubmed

      • Characterization of the murine B7-1 genomic locus reveals an additional exon encoding an alternative cytoplasmic domain and a chromosomal location of chromosome 16, band B5. J Immunol. 1994 Dec 01; 153(11):5038-48. View in: Pubmed

      • Pivotal role of the B7:CD28 pathway in transplantation tolerance and tumor immunity. Blood. 1994 Nov 15; 84(10):3261-82. View in: Pubmed

      • Prevention of T cell anergy by signaling through the gamma c chain of the IL-2 receptor. Science. 1994 Nov 11; 266(5187):1039-42. View in: Pubmed

      • CD2 is involved in maintenance and reversal of human alloantigen-specific clonal anergy. J Exp Med. 1994 Nov 01; 180(5):1665-73. View in: Pubmed

      • Blockade of the CD28 co-stimulatory pathway: a means to induce tolerance. Curr Opin Immunol. 1994 Oct; 6(5):797-807. View in: Pubmed

      • Role of CD27 in T cell immune response. Analysis by recombinant soluble CD27. J Immunol. 1994 Aug 15; 153(4):1421-9. View in: Pubmed

      • Expression cloning of a cDNA for human leukotriene C4 synthase, an integral membrane protein conjugating reduced glutathione to leukotriene A4. Proc Natl Acad Sci U S A. 1994 Aug 02; 91(16):7663-7. View in: Pubmed

      • A negative regulatory function of B7 revealed in B7-1 transgenic mice. Immunity. 1994 Aug; 1(5):415-21. View in: Pubmed

      • Murine B7-2, an alternative CTLA4 counter-receptor that costimulates T cell proliferation and interleukin 2 production. J Exp Med. 1993 Dec 01; 178(6):2185-92. View in: Pubmed

      • Activated human B lymphocytes express three CTLA-4 counterreceptors that costimulate T-cell activation. Proc Natl Acad Sci U S A. 1993 Dec 01; 90(23):11059-63. View in: Pubmed

      • [Failing B7 costimulation engenders a peripheral clonal T-cell anergy in a human antigen-specific model]. Schweiz Med Wochenschr. 1993 Nov 27; 123(47):2255-6. View in: Pubmed

      • Cloning of B7-2: a CTLA-4 counter-receptor that costimulates human T cell proliferation. Science. 1993 Nov 05; 262(5135):909-11. View in: Pubmed

      • Uncovering of functional alternative CTLA-4 counter-receptor in B7-deficient mice. Science. 1993 Nov 05; 262(5135):907-9. View in: Pubmed

      • The 4F9 antigen is a member of the tetra spans transmembrane protein family and functions as an accessory molecule in T cell activation and adhesion. Cell Immunol. 1993 Nov; 152(1):249-60. View in: Pubmed

      • B7 but not intercellular adhesion molecule-1 costimulation prevents the induction of human alloantigen-specific tolerance. J Exp Med. 1993 Nov 01; 178(5):1753-63. View in: Pubmed

      • Human T-cell clonal anergy is induced by antigen presentation in the absence of B7 costimulation. Proc Natl Acad Sci U S A. 1993 Jul 15; 90(14):6586-90. View in: Pubmed

      • Identification, by protein sequencing and gene transfection, of sgp-60 as the murine homologue of CD48. Proc Natl Acad Sci U S A. 1993 Apr 15; 90(8):3418-22. View in: Pubmed

      • Effects of cyclosporin A, FK 506, and mycalamide A on the activation of murine CD4+ T cells by the murine B7 antigen. Eur J Immunol. 1993 Jan; 23(1):283-6. View in: Pubmed

      • Murine B7 antigen provides a sufficient costimulatory signal for antigen-specific and MHC-restricted T cell activation. J Immunol. 1992 Dec 15; 149(12):3802-8. View in: Pubmed

      • CTLA-4 and CD28 mRNA are coexpressed in most T cells after activation. Expression of CTLA-4 and CD28 mRNA does not correlate with the pattern of lymphokine production. J Immunol. 1992 Dec 15; 149(12):3795-801. View in: Pubmed

      • Early signaling defects in human T cells anergized by T cell presentation of autoantigen. J Exp Med. 1992 Jul 01; 176(1):177-86. View in: Pubmed

      • Expression and function of the murine B7 antigen, the major costimulatory molecule expressed by peritoneal exudate cells. Proc Natl Acad Sci U S A. 1992 May 01; 89(9):4210-4. View in: Pubmed

      • The gene for B7, a costimulatory signal for T-cell activation, maps to chromosomal region 3q13.3-3q21. Blood. 1992 Jan 15; 79(2):489-94. View in: Pubmed

      • The HB-6, CDw75, and CD76 differentiation antigens are unique cell-surface carbohydrate determinants generated by the beta-galactoside alpha 2,6-sialyltransferase. J Cell Biol. 1992 Jan; 116(2):423-35. View in: Pubmed

      • Murine B7 antigen provides an efficient costimulatory signal for activation of murine T lymphocytes via the T-cell receptor/CD3 complex. Proc Natl Acad Sci U S A. 1992 Jan 01; 89(1):271-5. View in: Pubmed

      • All advanced stage non-Hodgkin's lymphomas with a polymerase chain reaction amplifiable breakpoint of bcl-2 have residual cells containing the bcl-2 rearrangement at evaluation and after treatment. Blood. 1991 Dec 15; 78(12):3275-80. View in: Pubmed

      • Immunologic purging of marrow assessed by PCR before autologous bone marrow transplantation for B-cell lymphoma. N Engl J Med. 1991 Nov 28; 325(22):1525-33. View in: Pubmed

      • Selective induction of B7/BB-1 on interferon-gamma stimulated monocytes: a potential mechanism for amplification of T cell activation through the CD28 pathway. Cell Immunol. 1991 Oct 15; 137(2):429-37. View in: Pubmed

      • Structure, expression, and T cell costimulatory activity of the murine homologue of the human B lymphocyte activation antigen B7. J Exp Med. 1991 Sep 01; 174(3):625-31. View in: Pubmed

      • B-cell surface antigen B7 provides a costimulatory signal that induces T cells to proliferate and secrete interleukin 2. Proc Natl Acad Sci U S A. 1991 Aug 01; 88(15):6575-9. View in: Pubmed

      • Follicular dendritic cells contain a unique gene repertoire demonstrated by single-cell polymerase chain reaction. Blood. 1991 Feb 15; 77(4):787-91. View in: Pubmed

      • Definition of T-cell specific DNA-binding factors that interact with a 3'-silencer in the CD4+ T-cell gene Rpt-1. Gene. 1989 Dec 28; 85(2):461-9. View in: Pubmed

      • Activation primes human B lymphocytes to respond to heat shock. J Exp Med. 1989 Nov 01; 170(5):1763-8. View in: Pubmed

      • B7, a new member of the Ig superfamily with unique expression on activated and neoplastic B cells. J Immunol. 1989 Oct 15; 143(8):2714-22. View in: Pubmed

      • Structural and functional studies of the early T lymphocyte activation 1 (Eta-1) gene. Definition of a novel T cell-dependent response associated with genetic resistance to bacterial infection. J Exp Med. 1989 07 01; 170(1):145-61. View in: Pubmed

      • Isolated human follicular dendritic cells display a unique antigenic phenotype. J Exp Med. 1989 Jun 01; 169(6):2043-58. View in: Pubmed

      • Interleukin 6 gene expression in normal and neoplastic B cells. J Clin Invest. 1989 May; 83(5):1512-8. View in: Pubmed

      • Expression and regulation of CD5 on in vitro activated human B cells. Eur J Immunol. 1989 May; 19(5):849-55. View in: Pubmed

      • Cloning and expression of a gamma-interferon-inducible gene in monocytes: a new member of a cytokine gene family. Int Immunol. 1989; 1(4):388-97. View in: Pubmed

      • Studies of in vitro activated CD5+ B cells. Blood. 1989 Jan; 73(1):202-8. View in: Pubmed

      • Pre-exposure of human B cells to recombinant IL-1 enhances subsequent proliferation. J Immunol. 1988 Nov 15; 141(10):3398-404. View in: Pubmed

      • rpt-1, an intracellular protein from helper/inducer T cells that regulates gene expression of interleukin 2 receptor and human immunodeficiency virus type 1. Proc Natl Acad Sci U S A. 1988 Apr; 85(8):2733-7. View in: Pubmed

      • B7, a B-cell-restricted antigen that identifies preactivated B cells. J Immunol. 1987 Nov 15; 139(10):3260-7. View in: Pubmed

      • Cloning and characterization of a novel T cell activation gene. J Immunol. 1987 Nov 01; 139(9):3126-31. View in: Pubmed

      Locations

      Location Avtar

      Dana-Farber Cancer Institute

      450 Brookline Avenue Dana 530 Boston, MA 02215
      Get Directions

      Dana-Farber Cancer Institute

      Location Avtar

      Dana-Farber Cancer Institute

      450 Brookline Avenue Dana 530 Boston, MA 02215
      Get Direction
      42.3374, -71.1082