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Harvey Cantor, MD


Researcher

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Researcher

  • Baruj Benacerraf Professor and Principal Investigator, Cancer Immunology and Virology, Dana-Farber Cancer Institute
  • Professor of Immunology, Harvard Medical School

Contact Information

  • Office Phone Number617-632-3348
  • Fax617-632-4630

Bio

After receiving an MD from New York University in 1967, Dr. Cantor trained at the National Institutes of Health and National Institute for Medical Research in London. After a residency in medicine at Stanford, he joined the DFCI and Harvard faculty in 1974; since 1997, he has chaired the Department of Cancer Immunology and AIDS. He directed the DF/HCC Program in Cancer Immunology and now serves on its Steering Committee. He engages in teaching/training within the Harvard Medical School Graduate Program in Immunology and directs NIH postdoctoral training programs in AIDS research and cancer immunology.

Recent Awards:

  • Gershon Memorial Lecture, Yale University 2002
  • Crano Memorial Lecture, University of Pittsburgh 2003
  • Clontech Lecture, Indiana University 2005
  • Member, American Academy of Arts & Sciences 2010-
  • Fellow in Medical Sciences, American Association for the Advancement of Science 2005-
  • Member, National Academy of Sciences 2002-

Research

Development and function of T cells, their subsets and distinctive markers


The Cantor lab investigates fundamental questions in the development of the immune response, and how it may be effectively stimulated by vaccines to fight against cancer and other diseases. Several distinct lines of research are currently underway and focus on the development and function of T cells, with special emphasis on the contribution of Qa-1-restricted CD8+ regulatory T cells (Treg) that recognize peptides associated with the murine class Ib MHC molecule Qa-1 (HLA-E in man) expressed at the surface of follicular T helper (TFH) cells.

Identification of a suppressive sublineage of CD8 T cells that prevents generation of pathogenic autoantibody production and ensures self tolerance has fundamental relevance to understanding the immune system, and may also allow more efficient development of cancer vaccines in view of the propensity of tumors to induce high levels of suppressive T cells which prevent immune destruction by the host.

While most approaches to immunotherapy have focused on the contribution of CD4+ regulatory T-cells, recent studies show that increased targeting of Qa-1+ TFH cells by CD8 Treg inhibits tumor immunity, and disruption of this inhibitory interaction enhances the protective immune response in a murine model of melanoma. Genetic disruption of CD8 Treg activity resulting in enhanced anti-tumor immunity is associated with a robust antibody response to tumor-associated antigens (TAA) that cooperate with CD8 effector T cells to constrain tumor growth. These studies suggest that the CD8+ T effector–Treg ratio in tumor lymphocyte infiltrates may represent a useful prognostic index for cancer development, and that specific depletion of CD8 Treg represents a novel and potentially effective strategy for cancer treatment.

More recently, we have found that the transcription factor Helios acts as a guardian of self-tolerance in both CD4 and CD8 regulatory lineages. Definition of Helios as a key transcriptional regulator that ensures a stable Treg phenotype and maintenance of self-tolerance in the face of inflammatory and infectious challenge represents a critical new insight into T-cell biology, and suggests novel strategies for manipulating the immune response in the context of cancer. Ongoing investigations are aimed at identification of the human homologue of CD8+ Treg for analysis of their potential contribution to anti-tumor immunity.

From antibody specificity to T cell recognition. J Exp Med. 2021 04 05; 218(4).
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A new chapter in the CD8 T reg story. J Exp Med. 2021 01 04; 218(1).
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Mechanism of EBV inducing anti-tumour immunity and its therapeutic use. Nature. 2021 02; 590(7844):157-162.
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Overcoming Immune Checkpoint Blockade Resistance via EZH2 Inhibition. Trends Immunol. 2020 10; 41(10):948-963.
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Control of Germinal Center Localization and Lineage Stability of Follicular Regulatory T Cells by the Blimp1 Transcription Factor. Cell Rep. 2020 Apr 28; 31(4):107575.
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Regulatory CD8 T cells that recognize Qa-1 expressed by CD4 T-helper cells inhibit rejection of heart allografts. Proc Natl Acad Sci U S A. 2020 03 17; 117(11):6042-6046.
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NK Cells Regulate CD8+ T Cell Mediated Autoimmunity. Front Cell Infect Microbiol. 2020; 10:36.
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Control of Germinal Center Localization and Lineage Stability of Follicular Regulatory T Cells by the Blimp1 Transcription Factor. Cell Rep. 2019 11 12; 29(7):1848-1861.e6.
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Regulatory T cells subdue an autoimmune disease. Nature. 2019 08; 572(7770):443-445.
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New Insights Into the Biology of CD8 Regulatory T Cells. Adv Immunol. 2018; 140:1-20.
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Chromatin remodeling by the NuRD complex regulates development of follicular helper and regulatory T cells. Proc Natl Acad Sci U S A. 2018 06 26; 115(26):6780-6785.
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Comparative transcriptome analysis reveals distinct genetic modules associated with Helios expression in intratumoral regulatory T cells. Proc Natl Acad Sci U S A. 2018 02 27; 115(9):2162-2167.
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Signaling by the Epstein-Barr virus LMP1 protein induces potent cytotoxic CD4+ and CD8+ T cell responses. Proc Natl Acad Sci U S A. 2018 01 23; 115(4):E686-E695.
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?d T Cells Contribute to Injury in the Developing Brain. Am J Pathol. 2018 03; 188(3):757-767.
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Lymphocytes Negatively Regulate NK Cell Activity via Qa-1b following Viral Infection. Cell Rep. 2017 Nov 28; 21(9):2528-2540.
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Erratum: The microRNA miR-31 inhibits CD8+ T cell function in chronic viral infection. Nat Immunol. 2017 09 19; 18(10):1173.
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The microRNA miR-31 inhibits CD8+ T cell function in chronic viral infection. Nat Immunol. 2017 Jul; 18(7):791-799.
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MHC Ib molecule Qa-1 presents Mycobacterium tuberculosis peptide antigens to CD8+ T cells and contributes to protection against infection. PLoS Pathog. 2017 May; 13(5):e1006384.
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Suppression of Th17 cell differentiation by misshapen/NIK-related kinase MINK1. J Exp Med. 2017 05 01; 214(5):1453-1469.
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Instability of Helios-deficient Tregs is associated with conversion to a T-effector phenotype and enhanced antitumor immunity. Proc Natl Acad Sci U S A. 2016 May 31; 113(22):6248-53.
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Ezh2 regulates differentiation and function of natural killer cells through histone methyltransferase activity. Proc Natl Acad Sci U S A. 2015 Dec 29; 112(52):15988-93.
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Stable inhibitory activity of regulatory T cells requires the transcription factor Helios. Science. 2015 Oct 16; 350(6258):334-9.
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Intracellular osteopontin regulates homeostasis and function of natural killer cells. Proc Natl Acad Sci U S A. 2015 Jan 13; 112(2):494-9.
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A p85a-osteopontin axis couples the receptor ICOS to sustained Bcl-6 expression by follicular helper and regulatory T cells. Nat Immunol. 2015 Jan; 16(1):96-106.
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The path to reactivation of antitumor immunity and checkpoint immunotherapy. Cancer Immunol Res. 2014 Oct; 2(10):926-36.
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CD4 T-cell subsets and tumor immunity: the helpful and the not-so-helpful. Cancer Immunol Res. 2014 Feb; 2(2):91-8.
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In vivo discovery of immunotherapy targets in the tumour microenvironment. Nature. 2014 Feb 06; 506(7486):52-7.
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Disruption of CD8+ Treg activity results in expansion of T follicular helper cells and enhanced antitumor immunity. Cancer Immunol Res. 2014 Mar; 2(3):207-16.
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Genetic disruption of CD8+ Treg activity enhances the immune response to viral infection. Proc Natl Acad Sci U S A. 2013 Dec 24; 110(52):21089-94.
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Negative selection, not receptor editing, is a physiological response of autoreactive thymocytes. J Exp Med. 2013 Sep 23; 210(10):1911-8.
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Amelioration of arthritis through mobilization of peptide-specific CD8+ regulatory T cells. J Clin Invest. 2013 Mar; 123(3):1382-9.
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Glatiramer acetate ameliorates inflammatory bowel disease in mice through the induction of Qa-1-restricted CD8? regulatory cells. Eur J Immunol. 2013 Jan; 43(1):125-36.
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Regulation of self-tolerance by Qa-1-restricted CD8(+) regulatory T cells. Semin Immunol. 2011 Dec; 23(6):446-52.
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TCR-dependent transformation of mature memory phenotype T cells in mice. J Clin Invest. 2011 Oct; 121(10):3834-45.
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Mobilization of natural killer cells inhibits development of collagen-induced arthritis. Proc Natl Acad Sci U S A. 2011 Aug 30; 108(35):14584-9.
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Physiological induction of regulatory Qa-1-restricted CD8+ T cells triggered by endogenous CD4+ T cell responses. PLoS One. 2011; 6(6):e21628.
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CD8+ T regulatory cells express the Ly49 Class I MHC receptor and are defective in autoimmune prone B6-Yaa mice. Proc Natl Acad Sci U S A. 2011 Feb 01; 108(5):2010-5.
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Inhibition of follicular T-helper cells by CD8(+) regulatory T cells is essential for self tolerance. Nature. 2010 Sep 16; 467(7313):328-32.
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Proinflammatory T helper type 17 cells are effective B-cell helpers. Proc Natl Acad Sci U S A. 2010 Aug 10; 107(32):14292-7.
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Control of T cell reactivation by regulatory Qa-1-restricted CD8+ T cells. J Immunol. 2010 Jun 15; 184(12):6585-91.
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Unexpected role of clathrin adaptor AP-1 in MHC-dependent positive selection of T cells. Proc Natl Acad Sci U S A. 2010 Feb 09; 107(6):2556-61.
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Analysis of the cellular mechanism underlying inhibition of EAE after treatment with anti-NKG2A F(ab')2. Proc Natl Acad Sci U S A. 2010 Feb 09; 107(6):2562-7.
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Reprogramming after chromosome transfer into mouse blastomeres. Curr Biol. 2009 Aug 25; 19(16):1403-9.
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Regulation of T-helper-cell lineage development by osteopontin: the inside story. Nat Rev Immunol. 2009 02; 9(2):137-41.
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Constitutive JAK3 activation induces lymphoproliferative syndromes in murine bone marrow transplantation models. Blood. 2009 Mar 19; 113(12):2746-54.
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Regulation of CD8+ regulatory T cells: Interruption of the NKG2A-Qa-1 interaction allows robust suppressive activity and resolution of autoimmune disease. Proc Natl Acad Sci U S A. 2008 Dec 09; 105(49):19420-5.
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Generation and regulation of CD8(+) regulatory T cells. Cell Mol Immunol. 2008 Dec; 5(6):401-6.
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Engagement of the type I interferon receptor on dendritic cells inhibits T helper 17 cell development: role of intracellular osteopontin. Immunity. 2008 Jul 18; 29(1):68-78.
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T-bet plays a key role in NK-mediated control of melanoma metastatic disease. J Immunol. 2008 Jun 15; 180(12):8004-10.
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Alternative translation of osteopontin generates intracellular and secreted isoforms that mediate distinct biological activities in dendritic cells. Proc Natl Acad Sci U S A. 2008 May 20; 105(20):7235-9.
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Cutting edge: engagement of NKG2A on CD8+ effector T cells limits immunopathology in influenza pneumonia. J Immunol. 2008 Jan 01; 180(1):25-9.
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Qa-1(b)-dependent modulation of dendritic cell and NK cell cross-talk in vivo. J Immunol. 2007 Oct 01; 179(7):4608-15.
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Regulation of activated CD4+ T cells by NK cells via the Qa-1-NKG2A inhibitory pathway. Immunity. 2007 May; 26(5):593-604.
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The bridge between dendritic cells and asthma. Nat Med. 2007 May; 13(5):536-8.
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The immunoregulatory effects of Qa-1. Immunol Rev. 2006 Aug; 212:51-9.
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Osteopontin expression is essential for interferon-alpha production by plasmacytoid dendritic cells. Nat Immunol. 2006 May; 7(5):498-506.
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T-bet-dependent expression of osteopontin contributes to T cell polarization. Proc Natl Acad Sci U S A. 2005 Nov 22; 102(47):17101-6.
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Regulatory T cells and autoimmune disease. Immunol Rev. 2005 Apr; 204:195-207.
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The role of innate immunity in autoimmunity. J Exp Med. 2004 Dec 20; 200(12):1527-31.
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Signaling by the kinase MINK is essential in the negative selection of autoreactive thymocytes. Nat Immunol. 2005 Jan; 6(1):65-72.
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Qa-1 restriction of CD8+ suppressor T cells. J Clin Invest. 2004 Nov; 114(9):1218-21.
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Lack of requirement of osteopontin for inflammation, bone erosion, and cartilage damage in the K/BxN model of autoantibody-mediated arthritis. Arthritis Rheum. 2004 Aug; 50(8):2685-94.
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Engagement of B7 on effector T cells by regulatory T cells prevents autoimmune disease. Proc Natl Acad Sci U S A. 2004 Jul 13; 101(28):10398-403.
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Detailed analysis of gene expression during development of T cell lineages in the thymus. Proc Natl Acad Sci U S A. 2004 Jun 22; 101(25):9339-44.
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Analysis of regulatory CD8 T cells in Qa-1-deficient mice. Nat Immunol. 2004 May; 5(5):516-23.
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Reviving suppression? Nat Immunol. 2004 Apr; 5(4):347-9.
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Suppression of autoimmune disease after vaccination with autoreactive T cells that express Qa-1 peptide complexes. J Clin Invest. 2004 Apr; 113(8):1218-24.
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Thymic selection can compensate for mutations affecting T cell activation and generate a normal T cell repertoire in mutant mice. Proc Natl Acad Sci U S A. 2004 Jan 06; 101(1):210-4.
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Phosphorylation-dependent interaction of osteopontin with its receptors regulates macrophage migration and activation. J Leukoc Biol. 2002 Oct; 72(4):752-61.
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Analysis of the complex genomic structure of Bcl-x and its relationship to Bcl-x(gamma) expression after CD28-dependent costimulation. Mol Immunol. 2002 Sep; 39(1-2):45-55.
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T cell costimulation through CD28 depends on induction of the Bcl-xgamma isoform: analysis of Bcl-xgamma-deficient mice. J Exp Med. 2002 Jul 01; 196(1):87-95.
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Fas-dependent elimination of nonselected CD8 cells and lpr disease. J Immunol. 2002 May 15; 168(10):4960-7.
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T cell-dependent and -independent pathways to tissue destruction following herpes simplex virus-1 infection. Eur J Immunol. 2002 05; 32(5):1414-9.
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Absence of the CD44 gene prevents sarcoma metastasis. Cancer Res. 2002 Apr 15; 62(8):2281-6.
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Cutting edge: Attenuated experimental autoimmune encephalomyelitis in eta-1/osteopontin-deficient mice. J Immunol. 2002 Mar 01; 168(5):2096-9.
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Differential roles of osteopontin/Eta-1 in early and late lpr disease. Clin Exp Immunol. 2001 Dec; 126(3):578-83.
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Effect of Fas and Fas ligand deficiency in resistance of C57BL/6 mice to HSV-1 keratitis and chorioretinitis. Invest Ophthalmol Vis Sci. 2001 Oct; 42(11):2505-9.
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Analysis of the relationship between viral infection and autoimmune disease. Immunity. 2001 Jul; 15(1):137-47.
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Costimulation by extracellular matrix proteins determines the response to TCR ligation. Cell Immunol. 2001 May 25; 210(1):30-40.
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On the relationship between viral infection and autoimmunity. J Autoimmun. 2001 May; 16(3):341-5.
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Differential cytokine requirements for regulation of autoimmune gastritis and colitis by CD4(+)CD25(+) T cells. J Autoimmun. 2001 Mar; 16(2):115-23.
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Definition of a novel binding site on CD8 cells for a conserved region of the MHC class Ib molecule Qa-1 that regulates IFN-gamma expression. Eur J Immunol. 2001 Jan; 31(1):87-93.
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Eta-1 (osteopontin): an early component of type-1 (cell-mediated) immunity. Science. 2000 Feb 04; 287(5454):860-4.
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T-cell receptor crossreactivity and autoimmune disease. Adv Immunol. 2000; 75:209-33.
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Inactivation of misselected CD8 T cells by CD8 gene methylation and cell death. Science. 1999 May 14; 284(5417):1187-91.
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Activation of T cells by superantigen: cytokine production but not apoptosis depends on MEK-1 activity. Eur J Immunol. 1998 11; 28(11):3749-54.
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Molecular mimicry by herpes simplex virus-type 1: autoimmune disease after viral infection. Science. 1998 Feb 27; 279(5355):1344-7.
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Suppression of immune responses by CD8 cells. II. Qa-1 on activated B cells stimulates CD8 cell suppression of T helper 2 responses. J Immunol. 1998 Jan 15; 160(2):566-71.
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Suppression of immune responses by CD8 cells. I. Superantigen-activated CD8 cells induce unidirectional Fas-mediated apoptosis of antigen-activated CD4 cells. J Immunol. 1998 Jan 15; 160(2):559-65.
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A novel Bcl-x isoform connected to the T cell receptor regulates apoptosis in T cells. Immunity. 1997 Nov; 7(5):629-39.
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Localization and treatment of an oxidation-sensitive defect within the TCR-coupled signalling pathway that is associated with normal and premature immunologic aging. Growth Dev Aging. 1997 Fall-Winter; 61(3-4):191-207.
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Measurement of apoptosis in heterogenous cell populations. Cytometry. 1997 Feb 01; 27(2):136-44.
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Interaction between CD44 and osteopontin as a potential basis for metastasis formation. Proc Assoc Am Physicians. 1997 Jan; 109(1):1-9.
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The immunology of Eta-1/osteopontin. Cytokine Growth Factor Rev. 1996 Oct; 7(3):241-8.
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Receptor-ligand interaction between CD44 and osteopontin (Eta-1). Science. 1996 Jan 26; 271(5248):509-12.
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Resistance to herpes stromal keratitis conferred by an IgG2a-derived peptide. Nature. 1995 Aug 03; 376(6539):431-4.
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The role of Eta-1/osteopontin in the pathogenesis of immunological disorders. Ann N Y Acad Sci. 1995 Apr 21; 760:143-50.
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A signaling pathway coupled to T cell receptor ligation by MMTV superantigen leading to transient activation and programmed cell death. Immunity. 1995 Apr; 2(4):363-72.
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Activation of T cells by superantigen in class II-negative mice. J Immunol. 1994 Dec 01; 153(11):4853-61.
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Phosphatidylinositol synthesis is a proximal event in intracellular signaling coupled to T cell receptor ligation. Differential induction by conventional antigen and retroviral superantigen. J Immunol. 1994 May 01; 152(9):4433-43.
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Thymocyte development in major histocompatibility complex-deficient mice: evidence for stochastic commitment to the CD4 and CD8 lineages. Proc Natl Acad Sci U S A. 1993 Nov 15; 90(22):10739-43.
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HIV glycoprotein as a superantigen. A mechanism of autoimmunity and implications for a vaccination strategy. Med Hypotheses. 1993 Sep; 41(3):247-50.
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Structural features of two T-cell-specific genes that suggest a potential role in HTLV-I-associated pathology. AIDS Res Hum Retroviruses. 1993 Feb; 9(2):105-7.
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Immunoregulatory effects of superantigens: interactions of staphylococcal enterotoxins with host MHC and non-MHC products. Immunol Rev. 1993 Feb; 131:27-42.
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Molecular and cellular basis of genetic resistance to bacterial infection: the role of the early T-lymphocyte activation-1/osteopontin gene. Crit Rev Immunol. 1993; 13(3-4):225-46.
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Clonal unresponsiveness results from an interaction between staphylococcal enterotoxin B and T cells expressing unexpected V beta elements. Int Immunol. 1992 Aug; 4(8):851-9.
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Polyclonal B cell activation by the Eta-1 cytokine and the development of systemic autoimmune disease. J Immunol. 1991 Nov 01; 147(9):2902-6.
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Conventional antigen and superantigen may be coupled to distinct and cooperative T-cell activation pathways. Proc Natl Acad Sci U S A. 1991 Oct 01; 88(19):8705-9.
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Differential induction of interferon gamma gene expression after activation of CD4+ T cells by conventional antigen and Mls superantigen. Proc Natl Acad Sci U S A. 1991 Apr 01; 88(7):2736-9.
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Dysregulated expression of the T cell cytokine Eta-1 in CD4-8- lymphocytes during the development of murine autoimmune disease. J Exp Med. 1990 Oct 01; 172(4):1177-83.
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Limiting dilution analysis of ontogeny of self- and allo-reactive thymocytes of C57BL/6J mouse. Thymus. 1990 Sep; 16(2):89-98.
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Alternative pathways of T-cell activation and positive clonal selection. Immunol Rev. 1990 Aug; 116:85-100.
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Definition of a specific interaction between the early T lymphocyte activation 1 (Eta-1) protein and murine macrophages in vitro and its effect upon macrophages in vivo. J Exp Med. 1990 Jun 01; 171(6):1931-42.
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Definition of T-cell specific DNA-binding factors that interact with a 3'-silencer in the CD4+ T-cell gene Rpt-1. Gene. 1989 Dec 28; 85(2):461-9.
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Structural and functional studies of the early T lymphocyte activation 1 (Eta-1) gene. Definition of a novel T cell-dependent response associated with genetic resistance to bacterial infection. J Exp Med. 1989 07 01; 170(1):145-61.
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Isolation of antigen-specific T cell clones from nonresponder mice. Eur J Immunol. 1988 Jan; 18(1):145-52.
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Alloreactivity of an OVA-specific T-cell clone. I. Stimulation by class II MHC and novel non-MHC B-cell determinants. Immunogenetics. 1987; 26(4-5):193-203.
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Activation requirements of cloned inducer T cells. III. Need for two stimulator cells in the response of a cloned line to Mls determinants. J Immunol. 1986 Aug 15; 137(4):1109-14.
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Analysis of insulin-specific T cell clones. I. Strategy for production of clonotypic antibody. J Immunol. 1986 May 01; 136(9):3184-8.
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High efficiency gene transfer into murine T cell clones using a retroviral vector. J Immunol. 1986 Mar 01; 136(5):1876-9.
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Activation requirements of cloned inducer T cells. II. The failure of some clones to respond to antigen presented by activated B cells. J Immunol. 1986 Jan; 136(2):446-51.
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Cloning of Ly-5 cDNA. Proc Natl Acad Sci U S A. 1985 Nov; 82(21):7360-3.
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Activation requirements of cloned inducer T cells. I. Differential inhibition by anti-L3T4 or anti-I-A is determined by the accessory cell population. J Immunol. 1985 Oct; 135(4):2243-8.
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B cell activation: role of dendritic and T cell factors in the response to thymic-independent and -dependent antigens. J Immunol. 1985 May; 134(5):2860-6.
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Antigen processing by macrophages: definition of the ligand recognized by T-inducer cells. Eur J Immunol. 1985 Apr; 15(4):362-8.
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A subset of Ly-1 inducer T cell clones activates B cell proliferation but directly inhibits subsequent IgG secretion. J Exp Med. 1985 Apr 01; 161(4):785-804.
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T cell regulation of antibody responses: an I-A-specific, autoreactive T cell collaborates with antigen-specific helper T cells to promote IgG responses. J Immunol. 1985 Feb; 134(2):691-4.
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A cloned MCGF cDNA encodes a multilineage hematopoietic growth factor: multiple activities of interleukin 3. J Immunol. 1985 Feb; 134(2):910-4.
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Evidence for defects in accessory and T cell subsets in mice expressing the xid defect. J Mol Cell Immunol. 1985; 2(2):61-9.
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Monoclonal helper T cells induce B cell responses to T-independent antigens: antigen-specific T cells are directly stimulated by activated B cells in the absence of antigen. J Immunol. 1985 Jan; 134(1):86-90.
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Identification of a unique B-cell-stimulating factor produced by a cloned dendritic cell. Proc Natl Acad Sci U S A. 1985 Jan; 82(1):183-7.
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Immunoregulation of T-dependent responses by a cloned dendritic cell. J Immunol. 1984 Sep; 133(3):1174-8.
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Cloned mouse mast cells derived from immunized lymph node cells and from foetal liver cells exhibit characteristics of bone marrow-derived mast cells containing chondroitin sulphate E proteoglycan. Immunology. 1984 Jul; 52(3):563-75.
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T cell surface I-J glycoprotein. Concerted action of chromosome-4 and -17 genes forms an epitope dependent on alpha-D-mannosyl residues. J Exp Med. 1984 Jun 01; 159(6):1604-17.
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Immunoregulatory activities of autoreactive T cells: an I-A-specific T cell clone mediates both help and suppression of antibody responses. J Immunol. 1984 May; 132(5):2237-43.
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Analogs that compete for antigen binding to an arsonate-reactive T-cell clone inhibit the functional response to arsonate. Cell. 1984 Apr; 36(4):889-95.
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Binding of antigen in the absence of histocompatibility proteins by arsonate-reactive T-cell clones. Cell. 1984 Apr; 36(4):879-88.
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Chromosome 4 Jt gene controls murine T cell surface I-J expression. Science. 1984 Feb 10; 223(4636):559-63.
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Activation specificity of arsonate-reactive T cell clones. Structural requirements for hapten recognition and comparison with monoclonal antibodies. J Exp Med. 1984 Feb 01; 159(2):479-94.
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Isolation and characterization of a mouse cDNA clone that expresses mast-cell growth-factor activity in monkey cells. Proc Natl Acad Sci U S A. 1984 Feb; 81(4):1070-4.
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Acquisition of paralytic activity by inducer cells. J Mol Cell Immunol. 1984; 1(2):91-100.
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Hapten reactive inducer T cells. II. Evidence that a secreted form of the T cell receptor induces antibody production. J Exp Med. 1983 Dec 01; 158(6):1881-94.
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Affinity-purified antigen-specific products produced by T cells share epitopes recognized by heterologous antisera raised against several different antigen-specific products from T cells. Cell Immunol. 1983 Dec; 82(2):232-45.
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Lysis of inducer T cell clones by activated macrophages and macrophage-like cell lines. J Exp Med. 1983 Oct 01; 158(4):1243-58.
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Specificity of T cell clones for antigen and autologous major histocompatibility complex products determines specificity for foreign major histocompatibility complex products. J Exp Med. 1983 Aug 01; 158(2):428-37.
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Sequential expression of new gene programs in inducer T-cell clones. Proc Natl Acad Sci U S A. 1983 Jul; 80(13):4094-8.
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Definition of two pathways for generation of suppressor T-cell activity. Proc Natl Acad Sci U S A. 1983 Jun; 80(12):3779-81.
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Hapten-reactive inducer T cells. I. Definition of two classes of hapten-specific inducer cells. J Exp Med. 1983 Jun 01; 157(6):1906-19.
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Disparate functional properties of two interleukin 1-responsive Ly-1+2- T cell clones: distinction of T cell growth factor and T cell-replacing factor activities. J Immunol. 1983 Apr; 130(4):1743-8.
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Cloned mouse cells with natural killer function and cloned suppressor T cells express ultrastructural and biochemical features not shared by cloned inducer T cells. J Exp Med. 1983 Mar 01; 157(3):843-61.
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Alloreactive T-cell clones. Ly phenotypes predict both function and specificity for major histocompatibility complex products. Immunogenetics. 1983; 17(2):147-65.
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Mouse mast cell clones: modulation of functional maturity in vitro. Monogr Allergy. 1983; 18:166-70.
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Mast cell clones: a model for the analysis of cellular maturation. J Cell Biol. 1982 Nov; 95(2 Pt 1):435-44.
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Proteins synthesized by inducer T cells: evidence for a mitogenic peptide shared by inducer molecules that stimulate different cell types. Cell. 1982 Oct; 30(3):707-13.
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A cloned cell line mediating natural killer cell function inhibits immunoglobulin secretion. J Exp Med. 1982 Aug 01; 156(2):658-63.
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A cloned cell with NK function resembles basophils by ultrastructure and expresses IgE receptors. Nature. 1982 Jul 15; 298(5871):288-90.
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T-cell sets that control B-cell secretion of antigen-specific immunoglobulin also control secretion of nonspecific immunoglobulin. Cell Immunol. 1982 Jul 01; 70(2):271-6.
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Ultrastructural identification of the mouse basophil. Blood. 1982 Jun; 59(6):1279-85.
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Antigen-specific T lymphocyte clones. III. Papain splits purified T suppressor molecules into two functional domains. J Exp Med. 1982 Apr 01; 155(4):981-93.
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Specific regulation of immune responses by products of T cell clones. Pharmacol Rev. 1982 Mar; 34(1):63-4.
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The immune response to agents that cause acute and chronic diseases. J Cell Biochem. 1982; 20(2):105-12.
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Analysis of an antigen-specific H-2-restricted cell-free products(s) made by "I-J-" Ly-2 cells (Ly-2 TsF) that suppresses Ly-2 cell-depleted spleen cell activity. Eur J Immunol. 1981 Nov; 11(11):913-8.
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Analysis of antigen-specific, Ig-restricted cell-free material made by I-J+ Ly-1 cells (Ly-1 TsiF) that induces Ly-2+ cells to express suppressive activity. Eur J Immunol. 1981 Nov; 11(11):905-12.
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Regulation of immune responses: analysis with lymphocyte clones. Cell. 1981 Jul; 25(1):7-8.
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Multiple activities of a cloned cell line mediating natural killer cell function. J Exp Med. 1981 Jun 01; 153(6):1582-91.
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Contrasuppression. A novel immunoregulatory activity. J Exp Med. 1981 Jun 01; 153(6):1533-46.
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Inducer T lymphocytes synthesize a factor that stimulates proliferation of cloned mast cells. Nature. 1981 May 28; 291(5813):332-4.
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Antigen-specific T lymphocyte clones. II. Purification and biological characterization of an antigen-specific suppressive protein synthesized by cloned T cells. J Exp Med. 1981 May 01; 153(5):1260-74.
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Antigen-specific T lymphocyte clones. I. Characterization of a T lymphocyte clone expressing antigen-specific suppressive activity. J Exp Med. 1981 May 01; 153(5):1246-59.
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Multiple biologic activities of a cloned inducer T-cell population. Proc Natl Acad Sci U S A. 1981 Feb; 78(2):1157-61.
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Use of cloned populations of mouse lymphocytes to analyze cellular differentiation. Cell. 1981 Jan; 23(1):19-28.
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The role of T cell sets in the rejection of a methylcholanthrene-induced sarcoma (S1509a) in syngeneic mice. Am J Pathol. 1981 Jan; 102(1):20-7.
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Preliminary studies on the use of monoclonal antibodies as probes for sympathetic development. J Exp Biol. 1980 Dec; 89:73-83.
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Ly phenotype of lymphocytes producing murine migration inhibitory factor (MIF). J Immunol. 1980 Sep; 125(3):1117-9.
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Mode of regulation of natural killer cell activity by interferon. J Exp Med. 1980 Jul 01; 152(1):124-37.
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The origins of alloreactivity: differentiation of prekiller cells to viral infection results in alloreactive cytolytic T lymphocytes. J Immunol. 1980 Apr; 124(4):1858-60.
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Feedback suppression of the immune response in vitro. I. Activity of antigen-stimulated B cells. J Exp Med. 1980 Mar 01; 151(3):667-80.
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T cell-mediated immunity to oncornavirus-induced tumors. I. Ly phenotype of precursor and effector cytolytic T lymphocytes. J Immunol. 1980 Feb; 124(2):846-50.
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T cell-mediated immunity to oncornavirus-induced tumors. II. Ability of different T cell sets to prevent tumor growth in vivo. J Immunol. 1980 Feb; 124(2):851-4.
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V(H) gene products allow specific communication among immunologic cell sets. Contemp Top Immunobiol. 1980; 11:227-44.
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Stimulation of regulatory T cell circuits by immunoglobulin-dependent structures on activated B cells. Eur J Immunol. 1980 Jan; 10(1):21-6.
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Ly-1 inducer and Ly-1,2 acceptor T cells in the feedback suppression circuit bear an I-J-subregion controlled determinant. Immunogenetics. 1980; 11(6):549-57.
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Cellular communication and differentiation. Arthritis Rheum. 1979 Nov; 22(11):1153-60.
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Genetic control of immunoregulatory circuits. Genes linked to the Ig locus govern communication between regulatory T-cell sets. J Exp Med. 1979 Jul 01; 150(1):44-50.
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Immunological circuits: cellular composition. Fed Proc. 1979 Jun; 38(7):2058-64.
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Direct evidence that natural killer cells in nonimmune spleen cell populations prevent tumor growth in vivo. J Exp Med. 1979 May 01; 149(5):1260-4.
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Immunoregulatory circuits among T cell sets: effect of mode of immunization on determining which Lyl T cell sets will be activated. J Immunol. 1979 May; 122(5):1663-5.
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Control of the immune system by inhibitor and inducer T lymphocytes. Annu Rev Med. 1979; 30:269-77.
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Migratory patterns of the Ly subsets of T lymphocytes in the mouse. Adv Exp Med Biol. 1979; 114:51-4.
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Immunogenetic analysis of "natural killer" activity in the mouse. Immunol Rev. 1979; 44:3-12.
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The biologic significance of alloreactivity. The ontogeny of T-cell sets specific for alloantigens or modified self antigens. J Exp Med. 1978 Nov 01; 148(5):1414-22.
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The Qa-1 antigenic system. Relation of Qa-1 phenotypes to lymphocyte sets, mitogen responses, and immune functions. J Exp Med. 1978 Oct 01; 148(4):963-73.
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Biological significance of alloreactivity: T cells stimulated by Sendai virus-coated syngeneic cells specifically lyse allogeneic target cells. Proc Natl Acad Sci U S A. 1978 Oct; 75(10):5145-9.
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Immunoregulatory circuits among T-cell sets. Identification of a subpopulation of T-helper cells that induces feedback inhibition. J Exp Med. 1978 Oct 01; 148(4):871-7.
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Idiotype-specific T helper cells are required to induce idiotype-positive B memory cells to secrete antibody. Eur J Immunol. 1978 Aug; 8(8):600-6.
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Association of defective feedback suppressor T cell activity with autoimmunity in NZB mice. Arthritis Rheum. 1978 Jun; 21(5 Suppl):S180-4.
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Analysis of the cellular basis of idiotype-specific suppression. J Immunol. 1978 Jun; 120(6):2016-9.
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Molecular identification of a surface structure on B cells (Lyb-3) and its relationship to B cell triggering. J Immunol. 1978 May; 120(5):1733-40.
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Immunoregulatory circuits among T-cell sets. II. Physiologic role of feedback inhibition in vivo: absence in NZB mice. J Exp Med. 1978 Apr 01; 147(4):1116-25.
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Immunoregulatory circuits among T-cell sets. I. T-helper cells induce other T-cell sets to exert feedback inhibition. J Exp Med. 1978 Apr 01; 147(4):1106-15.
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Immunogenetic aspects of biologic communication: a hypothesis of evolution by program duplication. Birth Defects Orig Artic Ser. 1978; 14(2):249-83.
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Surface characteristics of T-lymphocyte subpopulations. Hosp Pract. 1977 Apr; 12(4):81-8.
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Identification of a B-cell surface structure involved in antigen-dependent triggering: absence of this structure on B cells from CBA/N mutant mice. J Exp Med. 1977 Jan 01; 145(1):10-20.
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Lymphocytes as models for the study of mammalian cellular differentiation. Immunol Rev. 1977 Jan; 33:105-24.
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Identification of a cell-surface antigen selectively expressed on the natural killer cell. J Exp Med. 1977 Jan 01; 145(1):1-9.
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Regulation of cellular and humoral immune responses by T-cell subclasses. Cold Spring Harb Symp Quant Biol. 1977; 41 Pt 1:23-32.
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Regulation of the immune response by T-cell subclasses. Contemp Top Immunobiol. 1977; 7:47-67.
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Maintenance of hyporesponsiveness to antigen by a distinct subclass of T lymphocytes. J Immunol. 1976 Dec; 117(6):2209-12.
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Independent differentiative pathways of Ly1 and Ly23 subclasses of T cells. Experimental production of mice deprived of selected T-cell subclasses. J Exp Med. 1976 Oct 01; 144(4):1128-33.
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T-cell regulation of antibody responses: demonstration of allotype-specific helper T cells and their specific removal by suppressor T cells. J Exp Med. 1976 Aug 01; 144(2):330-44.
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Terminal deoxynucleotidyl transferase is found in prothymocytes. J Exp Med. 1976 Aug 01; 144(2):543-8.
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Cell-mediated immunity: delayed-type hypersensitivity and cytotoxic responses are mediated by different T-cell subclasses. J Exp Med. 1976 Jun 01; 143(6):1534-9.
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Separation of helper T cells from suppressor T cells expressing different Ly components. I. Polyclonal activation: suppressor and helper activities are inherent properties of distinct T-cell subclasses. J Exp Med. 1976 Jun 01; 143(6):1382-90.
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Separation of helper T cells from suppressor T cells expressing different Ly components. II. Activation by antigen: after immunization, antigen-specific suppressor and helper activities are mediated by distinct T-cell subclasses. J Exp Med. 1976 Jun 01; 143(6):1391-40.
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Development and function of subpopulations of thymocytes and T lymphocytes. Prog Allergy. 1976; 20:1-64.
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Functional subclasses of T lymphocytes bearing different Ly antigens. II. Cooperation between subclasses of Ly+ cells in the generation of killer activity. J Exp Med. 1975 Jun 01; 141(6):1390-9.
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Functional subclasses of T-lymphocytes bearing different Ly antigens. I. The generation of functionally distinct T-cell subclasses is a differentiative process independent of antigen. J Exp Med. 1975 Jun 01; 141(6):1376-89.
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Regulation of the immune response by subclasses of T lymphocytes. II. The effect of adult thymectomy upon humoral and cellular responses in mice. Eur J Immunol. 1975 May; 5(5):337-43.
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Regulation of the immune response by subclasses of T lymphocytes. I. Interactions between pre-killer T cells and regulatory T cells obtained from peripheral lymphoid tissues of mice. Eur J Immunol. 1975 May; 5(5):330-6.
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Development and function of subclasses of T cells. J Reticuloendothel Soc. 1975 Feb; 17(2):115-8.
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Characterization of subpopulations of T lymphocytes. I. Separation and functional studies of peripheral T-cells binding different amounts of fluorescent anti-Thy 1.2 (theta) antibody using a fluorescence-activated cell sorter (FACS). Cell Immunol. 1975 Jan; 15(1):180-96.
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The relationship of cell division to the generation of cytotoxic activity in mixed lymphocyte culture. J Exp Med. 1974 Dec 01; 140(6):1712-6.
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Immunological disease induced by injecting F1 lymphoid cells into certain parental strains. Immunology. 1974 Dec; 27(6):989-1007.
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Another approach to the problem of disparities between HL-A serotyping and mixed lymphocyte culturte response. Transplant Proc. 1972 Jun; 4(2):227-30.
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Maturation of reactivity to histocompatibility antigens. Transplant Proc. 1972 Jun; 4(2):159-62.
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Synergy among lymphoid cells mediating the graft-versus-host response. 3. Evidence for interaction between two types of thymus-derived cells. J Exp Med. 1972 Apr 01; 135(4):764-79.
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The effects of anti-theta antiserum upon graft-versus-host activity of spleen and lymph node cells. Cell Immunol. 1972 Mar; 3(3):461-9.
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T cells and the immune response. Prog Biophys Mol Biol. 1972; 25:73-82.
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Functional maturation of mouse thymic lymphocytes. Eur J Immunol. 1971 Dec; 1(6):459-61.
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Differential migration of helper and precursor spleen cells following immunization. Eur J Immunol. 1971 Dec; 1(6):462-4.
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The effect of polyinosinic-polycytidylic acid upon graft-vs-host activity in BALB/c mice. J Immunol. 1970 Apr; 104(4):1035-8.
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Studies of thoracic duct lymphocytes of mice. II. A quantitative comparison of the capacity of thoracic duct lymphocytes and other lymphoid cells to induce graft-versus-host reactions. J Immunol. 1970 Feb; 104(2):409-13.
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Synergy among lymphoid cells mediating the graft-versus-host response. I. Synergy in graft-versus-host reactions produced by cells from NZB-Bl mice. J Exp Med. 1970 Feb; 131(2):223-34.
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Synergy among lymphoid cells mediating the graft-versus-host response. II. Synergy in graft-versus-host reactions produced by Balb-c lymphoid cells of differing anatomic origin. J Exp Med. 1970 Feb; 131(2):235-46.
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