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Harvey Cantor, MD

Harvey Cantor, MD

Researcher
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Contact Information

Office Phone Number

617-632-3348

Fax

617-632-4630

Appointments

617-632-3348

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Biography

Harvey Cantor, MD

After receiving an MD from New York University in 1967, Dr. Cantor trained at the National Institutes of Health and National Institute for Medical Research in London. After a residency in medicine at Stanford, he joined the DFCI and Harvard faculty in 1974; since 1997, he has chaired the Department of Cancer Immunology and AIDS. He directed the DF/HCC Program in Cancer Immunology and now serves on its Steering Committee. He engages in teaching/training within the Harvard Medical School Graduate Program in Immunology and directs NIH postdoctoral training programs in AIDS research and cancer immunology.

Researcher

Physician

Baruj Benacerraf Professor and Principal Investigator, Cancer Immunology and Virology, Dana-Farber Cancer Institute
Professor of Immunology, Harvard Medical School

Recent Awards

  • Gershon Memorial Lecture, Yale University 2002
  • Crano Memorial Lecture, University of Pittsburgh 2003
  • Clontech Lecture, Indiana University 2005
  • Member, American Academy of Arts & Sciences 2010-
  • Fellow in Medical Sciences, American Association for the Advancement of Science 2005-
  • Member, National Academy of Sciences 2002-

Research

    View Dr. Cantor’s Research

    Development and function of T cells, their subsets and distinctive markers

    The Cantor lab investigates fundamental questions in the development of the immune response, and how it may be effectively stimulated by vaccines to fight against cancer and other diseases. Several distinct lines of research are currently underway and focus on the development and function of T cells, with special emphasis on the contribution of Qa-1-restricted CD8+ regulatory T cells (Treg) that recognize peptides associated with the murine class Ib MHC molecule Qa-1 (HLA-E in man) expressed at the surface of follicular T helper (TFH) cells.

    Identification of a suppressive sublineage of CD8 T cells that prevents generation of pathogenic autoantibody production and ensures self tolerance has fundamental relevance to understanding the immune system, and may also allow more efficient development of cancer vaccines in view of the propensity of tumors to induce high levels of suppressive T cells which prevent immune destruction by the host.

    While most approaches to immunotherapy have focused on the contribution of CD4+ regulatory T-cells, recent studies show that increased targeting of Qa-1+ TFH cells by CD8 Treg inhibits tumor immunity, and disruption of this inhibitory interaction enhances the protective immune response in a murine model of melanoma. Genetic disruption of CD8 Treg activity resulting in enhanced anti-tumor immunity is associated with a robust antibody response to tumor-associated antigens (TAA) that cooperate with CD8 effector T cells to constrain tumor growth. These studies suggest that the CD8+ T effector–Treg ratio in tumor lymphocyte infiltrates may represent a useful prognostic index for cancer development, and that specific depletion of CD8 Treg represents a novel and potentially effective strategy for cancer treatment.

    More recently, we have found that the transcription factor Helios acts as a guardian of self-tolerance in both CD4 and CD8 regulatory lineages. Definition of Helios as a key transcriptional regulator that ensures a stable Treg phenotype and maintenance of self-tolerance in the face of inflammatory and infectious challenge represents a critical new insight into T-cell biology, and suggests novel strategies for manipulating the immune response in the context of cancer. Ongoing investigations are aimed at identification of the human homologue of CD8+ Treg for analysis of their potential contribution to anti-tumor immunity.

    Research Departments

    Research Website

    https://www.dfhcc.harvard.edu/insider/member-detail?tx_hcc_persondetail%5Baction%5D=show&tx_hcc_persondetail%5Bcontroller%5D=Person&tx_hcc_persondetail%5Bperson%5D=486&cHash=8f077a96d586c38ee899b3bdcb7261fd

    Publications

      View Dr. Cantor's Publications

      • A narrow T cell receptor repertoire instructs thymic differentiation of MHC class Ib-restricted CD8+ regulatory T cells. J Clin Invest. 2024 Jan 02; 134(1). View in: Pubmed

      • Associations of cortical SPP1 and ITGAX with cognition and common neuropathologies in older adults. Alzheimers Dement. 2023 Sep 19. View in: Pubmed

      • Renegade T cell clones and autoimmune disease. Proc Natl Acad Sci U S A. 2023 08; 120(31):e2310236120. View in: Pubmed

      • Definition of the contribution of an Osteopontin-producing CD11c+ microglial subset to Alzheimer's disease. Proc Natl Acad Sci U S A. 2023 02 07; 120(6):e2218915120. View in: Pubmed

      • Antibody-mediated blockade of the IL23 receptor destabilizes intratumoral regulatory T cells and enhances immunotherapy. Proc Natl Acad Sci U S A. 2022 05 03; 119(18):e2200757119. View in: Pubmed

      • Definition of a mouse microglial subset that regulates neuronal development and proinflammatory responses in the brain. Proc Natl Acad Sci U S A. 2022 02 22; 119(8). View in: Pubmed

      • From antibody specificity to T cell recognition. J Exp Med. 2021 04 05; 218(4). View in: Pubmed

      • A new chapter in the CD8 T reg story. J Exp Med. 2021 01 04; 218(1). View in: Pubmed

      • Mechanism of EBV inducing anti-tumour immunity and its therapeutic use. Nature. 2021 02; 590(7844):157-162. View in: Pubmed

      • Overcoming Immune Checkpoint Blockade Resistance via EZH2 Inhibition. Trends Immunol. 2020 10; 41(10):948-963. View in: Pubmed

      • Control of Germinal Center Localization and Lineage Stability of Follicular Regulatory T Cells by the Blimp1 Transcription Factor. Cell Rep. 2020 Apr 28; 31(4):107575. View in: Pubmed

      • Regulatory CD8 T cells that recognize Qa-1 expressed by CD4 T-helper cells inhibit rejection of heart allografts. Proc Natl Acad Sci U S A. 2020 03 17; 117(11):6042-6046. View in: Pubmed

      • NK Cells Regulate CD8+ T Cell Mediated Autoimmunity. Front Cell Infect Microbiol. 2020; 10:36. View in: Pubmed

      • Control of Germinal Center Localization and Lineage Stability of Follicular Regulatory T Cells by the Blimp1 Transcription Factor. Cell Rep. 2019 11 12; 29(7):1848-1861.e6. View in: Pubmed

      • Regulatory T cells subdue an autoimmune disease. Nature. 2019 08; 572(7770):443-445. View in: Pubmed

      • New Insights Into the Biology of CD8 Regulatory T Cells. Adv Immunol. 2018; 140:1-20. View in: Pubmed

      • Chromatin remodeling by the NuRD complex regulates development of follicular helper and regulatory T cells. Proc Natl Acad Sci U S A. 2018 06 26; 115(26):6780-6785. View in: Pubmed

      • Comparative transcriptome analysis reveals distinct genetic modules associated with Helios expression in intratumoral regulatory T cells. Proc Natl Acad Sci U S A. 2018 02 27; 115(9):2162-2167. View in: Pubmed

      • Signaling by the Epstein-Barr virus LMP1 protein induces potent cytotoxic CD4+ and CD8+ T cell responses. Proc Natl Acad Sci U S A. 2018 01 23; 115(4):E686-E695. View in: Pubmed

      • ?d T Cells Contribute to Injury in the Developing Brain. Am J Pathol. 2018 03; 188(3):757-767. View in: Pubmed

      • Lymphocytes Negatively Regulate NK Cell Activity via Qa-1b following Viral Infection. Cell Rep. 2017 Nov 28; 21(9):2528-2540. View in: Pubmed

      • Erratum: The microRNA miR-31 inhibits CD8+ T cell function in chronic viral infection. Nat Immunol. 2017 09 19; 18(10):1173. View in: Pubmed

      • The microRNA miR-31 inhibits CD8+ T cell function in chronic viral infection. Nat Immunol. 2017 Jul; 18(7):791-799. View in: Pubmed

      • MHC Ib molecule Qa-1 presents Mycobacterium tuberculosis peptide antigens to CD8+ T cells and contributes to protection against infection. PLoS Pathog. 2017 May; 13(5):e1006384. View in: Pubmed

      • Suppression of Th17 cell differentiation by misshapen/NIK-related kinase MINK1. J Exp Med. 2017 05 01; 214(5):1453-1469. View in: Pubmed

      • Instability of Helios-deficient Tregs is associated with conversion to a T-effector phenotype and enhanced antitumor immunity. Proc Natl Acad Sci U S A. 2016 May 31; 113(22):6248-53. View in: Pubmed

      • Ezh2 regulates differentiation and function of natural killer cells through histone methyltransferase activity. Proc Natl Acad Sci U S A. 2015 Dec 29; 112(52):15988-93. View in: Pubmed

      • Stable inhibitory activity of regulatory T cells requires the transcription factor Helios. Science. 2015 Oct 16; 350(6258):334-9. View in: Pubmed

      • Intracellular osteopontin regulates homeostasis and function of natural killer cells. Proc Natl Acad Sci U S A. 2015 Jan 13; 112(2):494-9. View in: Pubmed

      • A p85a-osteopontin axis couples the receptor ICOS to sustained Bcl-6 expression by follicular helper and regulatory T cells. Nat Immunol. 2015 Jan; 16(1):96-106. View in: Pubmed

      • The path to reactivation of antitumor immunity and checkpoint immunotherapy. Cancer Immunol Res. 2014 Oct; 2(10):926-36. View in: Pubmed

      • CD4 T-cell subsets and tumor immunity: the helpful and the not-so-helpful. Cancer Immunol Res. 2014 Feb; 2(2):91-8. View in: Pubmed

      • In vivo discovery of immunotherapy targets in the tumour microenvironment. Nature. 2014 Feb 06; 506(7486):52-7. View in: Pubmed

      • Disruption of CD8+ Treg activity results in expansion of T follicular helper cells and enhanced antitumor immunity. Cancer Immunol Res. 2014 Mar; 2(3):207-16. View in: Pubmed

      • Genetic disruption of CD8+ Treg activity enhances the immune response to viral infection. Proc Natl Acad Sci U S A. 2013 Dec 24; 110(52):21089-94. View in: Pubmed

      • Negative selection, not receptor editing, is a physiological response of autoreactive thymocytes. J Exp Med. 2013 Sep 23; 210(10):1911-8. View in: Pubmed

      • Amelioration of arthritis through mobilization of peptide-specific CD8+ regulatory T cells. J Clin Invest. 2013 Mar; 123(3):1382-9. View in: Pubmed

      • Glatiramer acetate ameliorates inflammatory bowel disease in mice through the induction of Qa-1-restricted CD8? regulatory cells. Eur J Immunol. 2013 Jan; 43(1):125-36. View in: Pubmed

      • Regulation of self-tolerance by Qa-1-restricted CD8(+) regulatory T cells. Semin Immunol. 2011 Dec; 23(6):446-52. View in: Pubmed

      • TCR-dependent transformation of mature memory phenotype T cells in mice. J Clin Invest. 2011 Oct; 121(10):3834-45. View in: Pubmed

      • Mobilization of natural killer cells inhibits development of collagen-induced arthritis. Proc Natl Acad Sci U S A. 2011 Aug 30; 108(35):14584-9. View in: Pubmed

      • Physiological induction of regulatory Qa-1-restricted CD8+ T cells triggered by endogenous CD4+ T cell responses. PLoS One. 2011; 6(6):e21628. View in: Pubmed

      • CD8+ T regulatory cells express the Ly49 Class I MHC receptor and are defective in autoimmune prone B6-Yaa mice. Proc Natl Acad Sci U S A. 2011 Feb 01; 108(5):2010-5. View in: Pubmed

      • Inhibition of follicular T-helper cells by CD8(+) regulatory T cells is essential for self tolerance. Nature. 2010 Sep 16; 467(7313):328-32. View in: Pubmed

      • Proinflammatory T helper type 17 cells are effective B-cell helpers. Proc Natl Acad Sci U S A. 2010 Aug 10; 107(32):14292-7. View in: Pubmed

      • Control of T cell reactivation by regulatory Qa-1-restricted CD8+ T cells. J Immunol. 2010 Jun 15; 184(12):6585-91. View in: Pubmed

      • Unexpected role of clathrin adaptor AP-1 in MHC-dependent positive selection of T cells. Proc Natl Acad Sci U S A. 2010 Feb 09; 107(6):2556-61. View in: Pubmed

      • Analysis of the cellular mechanism underlying inhibition of EAE after treatment with anti-NKG2A F(ab')2. Proc Natl Acad Sci U S A. 2010 Feb 09; 107(6):2562-7. View in: Pubmed

      • Reprogramming after chromosome transfer into mouse blastomeres. Curr Biol. 2009 Aug 25; 19(16):1403-9. View in: Pubmed

      • Regulation of T-helper-cell lineage development by osteopontin: the inside story. Nat Rev Immunol. 2009 02; 9(2):137-41. View in: Pubmed

      • Constitutive JAK3 activation induces lymphoproliferative syndromes in murine bone marrow transplantation models. Blood. 2009 Mar 19; 113(12):2746-54. View in: Pubmed

      • Regulation of CD8+ regulatory T cells: Interruption of the NKG2A-Qa-1 interaction allows robust suppressive activity and resolution of autoimmune disease. Proc Natl Acad Sci U S A. 2008 Dec 09; 105(49):19420-5. View in: Pubmed

      • Generation and regulation of CD8(+) regulatory T cells. Cell Mol Immunol. 2008 Dec; 5(6):401-6. View in: Pubmed

      • Engagement of the type I interferon receptor on dendritic cells inhibits T helper 17 cell development: role of intracellular osteopontin. Immunity. 2008 Jul 18; 29(1):68-78. View in: Pubmed

      • T-bet plays a key role in NK-mediated control of melanoma metastatic disease. J Immunol. 2008 Jun 15; 180(12):8004-10. View in: Pubmed

      • Alternative translation of osteopontin generates intracellular and secreted isoforms that mediate distinct biological activities in dendritic cells. Proc Natl Acad Sci U S A. 2008 May 20; 105(20):7235-9. View in: Pubmed

      • Cutting edge: engagement of NKG2A on CD8+ effector T cells limits immunopathology in influenza pneumonia. J Immunol. 2008 Jan 01; 180(1):25-9. View in: Pubmed

      • Qa-1(b)-dependent modulation of dendritic cell and NK cell cross-talk in vivo. J Immunol. 2007 Oct 01; 179(7):4608-15. View in: Pubmed

      • Regulation of activated CD4+ T cells by NK cells via the Qa-1-NKG2A inhibitory pathway. Immunity. 2007 May; 26(5):593-604. View in: Pubmed

      • The bridge between dendritic cells and asthma. Nat Med. 2007 May; 13(5):536-8. View in: Pubmed

      • The immunoregulatory effects of Qa-1. Immunol Rev. 2006 Aug; 212:51-9. View in: Pubmed

      • Osteopontin expression is essential for interferon-alpha production by plasmacytoid dendritic cells. Nat Immunol. 2006 May; 7(5):498-506. View in: Pubmed

      • T-bet-dependent expression of osteopontin contributes to T cell polarization. Proc Natl Acad Sci U S A. 2005 Nov 22; 102(47):17101-6. View in: Pubmed

      • Regulatory T cells and autoimmune disease. Immunol Rev. 2005 Apr; 204:195-207. View in: Pubmed

      • The role of innate immunity in autoimmunity. J Exp Med. 2004 Dec 20; 200(12):1527-31. View in: Pubmed

      • Signaling by the kinase MINK is essential in the negative selection of autoreactive thymocytes. Nat Immunol. 2005 Jan; 6(1):65-72. View in: Pubmed

      • Qa-1 restriction of CD8+ suppressor T cells. J Clin Invest. 2004 Nov; 114(9):1218-21. View in: Pubmed

      • Lack of requirement of osteopontin for inflammation, bone erosion, and cartilage damage in the K/BxN model of autoantibody-mediated arthritis. Arthritis Rheum. 2004 Aug; 50(8):2685-94. View in: Pubmed

      • Engagement of B7 on effector T cells by regulatory T cells prevents autoimmune disease. Proc Natl Acad Sci U S A. 2004 Jul 13; 101(28):10398-403. View in: Pubmed

      • Detailed analysis of gene expression during development of T cell lineages in the thymus. Proc Natl Acad Sci U S A. 2004 Jun 22; 101(25):9339-44. View in: Pubmed

      • Analysis of regulatory CD8 T cells in Qa-1-deficient mice. Nat Immunol. 2004 May; 5(5):516-23. View in: Pubmed

      • Reviving suppression? Nat Immunol. 2004 Apr; 5(4):347-9. View in: Pubmed

      • Suppression of autoimmune disease after vaccination with autoreactive T cells that express Qa-1 peptide complexes. J Clin Invest. 2004 Apr; 113(8):1218-24. View in: Pubmed

      • Thymic selection can compensate for mutations affecting T cell activation and generate a normal T cell repertoire in mutant mice. Proc Natl Acad Sci U S A. 2004 Jan 06; 101(1):210-4. View in: Pubmed

      • Phosphorylation-dependent interaction of osteopontin with its receptors regulates macrophage migration and activation. J Leukoc Biol. 2002 Oct; 72(4):752-61. View in: Pubmed

      • Analysis of the complex genomic structure of Bcl-x and its relationship to Bcl-x(gamma) expression after CD28-dependent costimulation. Mol Immunol. 2002 Sep; 39(1-2):45-55. View in: Pubmed

      • T cell costimulation through CD28 depends on induction of the Bcl-xgamma isoform: analysis of Bcl-xgamma-deficient mice. J Exp Med. 2002 Jul 01; 196(1):87-95. View in: Pubmed

      • Fas-dependent elimination of nonselected CD8 cells and lpr disease. J Immunol. 2002 May 15; 168(10):4960-7. View in: Pubmed

      • T cell-dependent and -independent pathways to tissue destruction following herpes simplex virus-1 infection. Eur J Immunol. 2002 05; 32(5):1414-9. View in: Pubmed

      • Absence of the CD44 gene prevents sarcoma metastasis. Cancer Res. 2002 Apr 15; 62(8):2281-6. View in: Pubmed

      • Cutting edge: Attenuated experimental autoimmune encephalomyelitis in eta-1/osteopontin-deficient mice. J Immunol. 2002 Mar 01; 168(5):2096-9. View in: Pubmed

      • Differential roles of osteopontin/Eta-1 in early and late lpr disease. Clin Exp Immunol. 2001 Dec; 126(3):578-83. View in: Pubmed

      • Effect of Fas and Fas ligand deficiency in resistance of C57BL/6 mice to HSV-1 keratitis and chorioretinitis. Invest Ophthalmol Vis Sci. 2001 Oct; 42(11):2505-9. View in: Pubmed

      • Analysis of the relationship between viral infection and autoimmune disease. Immunity. 2001 Jul; 15(1):137-47. View in: Pubmed

      • Costimulation by extracellular matrix proteins determines the response to TCR ligation. Cell Immunol. 2001 May 25; 210(1):30-40. View in: Pubmed

      • On the relationship between viral infection and autoimmunity. J Autoimmun. 2001 May; 16(3):341-5. View in: Pubmed

      • Differential cytokine requirements for regulation of autoimmune gastritis and colitis by CD4(+)CD25(+) T cells. J Autoimmun. 2001 Mar; 16(2):115-23. View in: Pubmed

      • Definition of a novel binding site on CD8 cells for a conserved region of the MHC class Ib molecule Qa-1 that regulates IFN-gamma expression. Eur J Immunol. 2001 Jan; 31(1):87-93. View in: Pubmed

      • Eta-1 (osteopontin): an early component of type-1 (cell-mediated) immunity. Science. 2000 Feb 04; 287(5454):860-4. View in: Pubmed

      • T-cell receptor crossreactivity and autoimmune disease. Adv Immunol. 2000; 75:209-33. View in: Pubmed

      • Inactivation of misselected CD8 T cells by CD8 gene methylation and cell death. Science. 1999 May 14; 284(5417):1187-91. View in: Pubmed

      • Activation of T cells by superantigen: cytokine production but not apoptosis depends on MEK-1 activity. Eur J Immunol. 1998 11; 28(11):3749-54. View in: Pubmed

      • Molecular mimicry by herpes simplex virus-type 1: autoimmune disease after viral infection. Science. 1998 Feb 27; 279(5355):1344-7. View in: Pubmed

      • Suppression of immune responses by CD8 cells. II. Qa-1 on activated B cells stimulates CD8 cell suppression of T helper 2 responses. J Immunol. 1998 Jan 15; 160(2):566-71. View in: Pubmed

      • Suppression of immune responses by CD8 cells. I. Superantigen-activated CD8 cells induce unidirectional Fas-mediated apoptosis of antigen-activated CD4 cells. J Immunol. 1998 Jan 15; 160(2):559-65. View in: Pubmed

      • A novel Bcl-x isoform connected to the T cell receptor regulates apoptosis in T cells. Immunity. 1997 Nov; 7(5):629-39. View in: Pubmed

      • Localization and treatment of an oxidation-sensitive defect within the TCR-coupled signalling pathway that is associated with normal and premature immunologic aging. Growth Dev Aging. 1997 Fall-Winter; 61(3-4):191-207. View in: Pubmed

      • Measurement of apoptosis in heterogenous cell populations. Cytometry. 1997 Feb 01; 27(2):136-44. View in: Pubmed

      • Interaction between CD44 and osteopontin as a potential basis for metastasis formation. Proc Assoc Am Physicians. 1997 Jan; 109(1):1-9. View in: Pubmed

      • The immunology of Eta-1/osteopontin. Cytokine Growth Factor Rev. 1996 Oct; 7(3):241-8. View in: Pubmed

      • Receptor-ligand interaction between CD44 and osteopontin (Eta-1). Science. 1996 Jan 26; 271(5248):509-12. View in: Pubmed

      • Resistance to herpes stromal keratitis conferred by an IgG2a-derived peptide. Nature. 1995 Aug 03; 376(6539):431-4. View in: Pubmed

      • The role of Eta-1/osteopontin in the pathogenesis of immunological disorders. Ann N Y Acad Sci. 1995 Apr 21; 760:143-50. View in: Pubmed

      • A signaling pathway coupled to T cell receptor ligation by MMTV superantigen leading to transient activation and programmed cell death. Immunity. 1995 Apr; 2(4):363-72. View in: Pubmed

      • Activation of T cells by superantigen in class II-negative mice. J Immunol. 1994 Dec 01; 153(11):4853-61. View in: Pubmed

      • Phosphatidylinositol synthesis is a proximal event in intracellular signaling coupled to T cell receptor ligation. Differential induction by conventional antigen and retroviral superantigen. J Immunol. 1994 May 01; 152(9):4433-43. View in: Pubmed

      • Thymocyte development in major histocompatibility complex-deficient mice: evidence for stochastic commitment to the CD4 and CD8 lineages. Proc Natl Acad Sci U S A. 1993 Nov 15; 90(22):10739-43. View in: Pubmed

      • HIV glycoprotein as a superantigen. A mechanism of autoimmunity and implications for a vaccination strategy. Med Hypotheses. 1993 Sep; 41(3):247-50. View in: Pubmed

      • Structural features of two T-cell-specific genes that suggest a potential role in HTLV-I-associated pathology. AIDS Res Hum Retroviruses. 1993 Feb; 9(2):105-7. View in: Pubmed

      • Immunoregulatory effects of superantigens: interactions of staphylococcal enterotoxins with host MHC and non-MHC products. Immunol Rev. 1993 Feb; 131:27-42. View in: Pubmed

      • Molecular and cellular basis of genetic resistance to bacterial infection: the role of the early T-lymphocyte activation-1/osteopontin gene. Crit Rev Immunol. 1993; 13(3-4):225-46. View in: Pubmed

      • Clonal unresponsiveness results from an interaction between staphylococcal enterotoxin B and T cells expressing unexpected V beta elements. Int Immunol. 1992 Aug; 4(8):851-9. View in: Pubmed

      • Polyclonal B cell activation by the Eta-1 cytokine and the development of systemic autoimmune disease. J Immunol. 1991 Nov 01; 147(9):2902-6. View in: Pubmed

      • Conventional antigen and superantigen may be coupled to distinct and cooperative T-cell activation pathways. Proc Natl Acad Sci U S A. 1991 Oct 01; 88(19):8705-9. View in: Pubmed

      • Differential induction of interferon gamma gene expression after activation of CD4+ T cells by conventional antigen and Mls superantigen. Proc Natl Acad Sci U S A. 1991 Apr 01; 88(7):2736-9. View in: Pubmed

      • Dysregulated expression of the T cell cytokine Eta-1 in CD4-8- lymphocytes during the development of murine autoimmune disease. J Exp Med. 1990 Oct 01; 172(4):1177-83. View in: Pubmed

      • Limiting dilution analysis of ontogeny of self- and allo-reactive thymocytes of C57BL/6J mouse. Thymus. 1990 Sep; 16(2):89-98. View in: Pubmed

      • Alternative pathways of T-cell activation and positive clonal selection. Immunol Rev. 1990 Aug; 116:85-100. View in: Pubmed

      • Definition of a specific interaction between the early T lymphocyte activation 1 (Eta-1) protein and murine macrophages in vitro and its effect upon macrophages in vivo. J Exp Med. 1990 Jun 01; 171(6):1931-42. View in: Pubmed

      • Definition of T-cell specific DNA-binding factors that interact with a 3'-silencer in the CD4+ T-cell gene Rpt-1. Gene. 1989 Dec 28; 85(2):461-9. View in: Pubmed

      • Structural and functional studies of the early T lymphocyte activation 1 (Eta-1) gene. Definition of a novel T cell-dependent response associated with genetic resistance to bacterial infection. J Exp Med. 1989 07 01; 170(1):145-61. View in: Pubmed

      • Isolation of antigen-specific T cell clones from nonresponder mice. Eur J Immunol. 1988 Jan; 18(1):145-52. View in: Pubmed

      • Alloreactivity of an OVA-specific T-cell clone. I. Stimulation by class II MHC and novel non-MHC B-cell determinants. Immunogenetics. 1987; 26(4-5):193-203. View in: Pubmed

      • Activation requirements of cloned inducer T cells. III. Need for two stimulator cells in the response of a cloned line to Mls determinants. J Immunol. 1986 Aug 15; 137(4):1109-14. View in: Pubmed

      • Analysis of insulin-specific T cell clones. I. Strategy for production of clonotypic antibody. J Immunol. 1986 May 01; 136(9):3184-8. View in: Pubmed

      • High efficiency gene transfer into murine T cell clones using a retroviral vector. J Immunol. 1986 Mar 01; 136(5):1876-9. View in: Pubmed

      • Activation requirements of cloned inducer T cells. II. The failure of some clones to respond to antigen presented by activated B cells. J Immunol. 1986 Jan; 136(2):446-51. View in: Pubmed

      • Cloning of Ly-5 cDNA. Proc Natl Acad Sci U S A. 1985 Nov; 82(21):7360-3. View in: Pubmed

      • Activation requirements of cloned inducer T cells. I. Differential inhibition by anti-L3T4 or anti-I-A is determined by the accessory cell population. J Immunol. 1985 Oct; 135(4):2243-8. View in: Pubmed

      • B cell activation: role of dendritic and T cell factors in the response to thymic-independent and -dependent antigens. J Immunol. 1985 May; 134(5):2860-6. View in: Pubmed

      • Antigen processing by macrophages: definition of the ligand recognized by T-inducer cells. Eur J Immunol. 1985 Apr; 15(4):362-8. View in: Pubmed

      • A subset of Ly-1 inducer T cell clones activates B cell proliferation but directly inhibits subsequent IgG secretion. J Exp Med. 1985 Apr 01; 161(4):785-804. View in: Pubmed

      • T cell regulation of antibody responses: an I-A-specific, autoreactive T cell collaborates with antigen-specific helper T cells to promote IgG responses. J Immunol. 1985 Feb; 134(2):691-4. View in: Pubmed

      • A cloned MCGF cDNA encodes a multilineage hematopoietic growth factor: multiple activities of interleukin 3. J Immunol. 1985 Feb; 134(2):910-4. View in: Pubmed

      • Evidence for defects in accessory and T cell subsets in mice expressing the xid defect. J Mol Cell Immunol. 1985; 2(2):61-9. View in: Pubmed

      • Monoclonal helper T cells induce B cell responses to T-independent antigens: antigen-specific T cells are directly stimulated by activated B cells in the absence of antigen. J Immunol. 1985 Jan; 134(1):86-90. View in: Pubmed

      • Identification of a unique B-cell-stimulating factor produced by a cloned dendritic cell. Proc Natl Acad Sci U S A. 1985 Jan; 82(1):183-7. View in: Pubmed

      • Immunoregulation of T-dependent responses by a cloned dendritic cell. J Immunol. 1984 Sep; 133(3):1174-8. View in: Pubmed

      • Cloned mouse mast cells derived from immunized lymph node cells and from foetal liver cells exhibit characteristics of bone marrow-derived mast cells containing chondroitin sulphate E proteoglycan. Immunology. 1984 Jul; 52(3):563-75. View in: Pubmed

      • T cell surface I-J glycoprotein. Concerted action of chromosome-4 and -17 genes forms an epitope dependent on alpha-D-mannosyl residues. J Exp Med. 1984 Jun 01; 159(6):1604-17. View in: Pubmed

      • Immunoregulatory activities of autoreactive T cells: an I-A-specific T cell clone mediates both help and suppression of antibody responses. J Immunol. 1984 May; 132(5):2237-43. View in: Pubmed

      • Analogs that compete for antigen binding to an arsonate-reactive T-cell clone inhibit the functional response to arsonate. Cell. 1984 Apr; 36(4):889-95. View in: Pubmed

      • Binding of antigen in the absence of histocompatibility proteins by arsonate-reactive T-cell clones. Cell. 1984 Apr; 36(4):879-88. View in: Pubmed

      • Chromosome 4 Jt gene controls murine T cell surface I-J expression. Science. 1984 Feb 10; 223(4636):559-63. View in: Pubmed

      • Activation specificity of arsonate-reactive T cell clones. Structural requirements for hapten recognition and comparison with monoclonal antibodies. J Exp Med. 1984 Feb 01; 159(2):479-94. View in: Pubmed

      • Isolation and characterization of a mouse cDNA clone that expresses mast-cell growth-factor activity in monkey cells. Proc Natl Acad Sci U S A. 1984 Feb; 81(4):1070-4. View in: Pubmed

      • Acquisition of paralytic activity by inducer cells. J Mol Cell Immunol. 1984; 1(2):91-100. View in: Pubmed

      • Hapten reactive inducer T cells. II. Evidence that a secreted form of the T cell receptor induces antibody production. J Exp Med. 1983 Dec 01; 158(6):1881-94. View in: Pubmed

      • Affinity-purified antigen-specific products produced by T cells share epitopes recognized by heterologous antisera raised against several different antigen-specific products from T cells. Cell Immunol. 1983 Dec; 82(2):232-45. View in: Pubmed

      • Lysis of inducer T cell clones by activated macrophages and macrophage-like cell lines. J Exp Med. 1983 Oct 01; 158(4):1243-58. View in: Pubmed

      • Specificity of T cell clones for antigen and autologous major histocompatibility complex products determines specificity for foreign major histocompatibility complex products. J Exp Med. 1983 Aug 01; 158(2):428-37. View in: Pubmed

      • Sequential expression of new gene programs in inducer T-cell clones. Proc Natl Acad Sci U S A. 1983 Jul; 80(13):4094-8. View in: Pubmed

      • Definition of two pathways for generation of suppressor T-cell activity. Proc Natl Acad Sci U S A. 1983 Jun; 80(12):3779-81. View in: Pubmed

      • Hapten-reactive inducer T cells. I. Definition of two classes of hapten-specific inducer cells. J Exp Med. 1983 Jun 01; 157(6):1906-19. View in: Pubmed

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