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Irene Ghobrial, MD


Medical Oncology

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Irene Ghobrial, MD

Physician

  • Director, Clinical Investigator Research Program
  • Lavine Family Chair for Preventative Cancer Therapies
  • Professor of Medicine, Harvard Medical School

Centers/Programs

Clinical Interests

  • Multiple myeloma
  • Waldenström’s Macroglobulinemia

Contact Information

  • Appointments617-632-3823 (new)
    617-632-4218 (follow-up)
  • Office Phone Number617-632-4218
  • Fax617-582-8608

Bio

Dr. Ghobrial received her MD in 1995 from Cairo University School of Medicine, Egypt. She completed her Internal Medicine training at Wayne State University, Mich., and her Hematology/Oncology subspecialty training at Mayo Clinic College of Medicine, Minn. She joined Dana-Farber in the field of Waldenstrom's macroglobulinemia and multiple myeloma in 2005. She is conducting research in the area of homing and migration of B cells and novel therapeutic agents in Waldenstrom's macroglobulinemia and multiple myeloma.

Board Certification:

  • Hematology, 2004
  • Internal Medicine, 2001
  • Medical Oncology, 2004

Fellowship:

  • Mayo Clinic, Graduate Medical Education, Hematology & Oncology

Residency:

  • Cairo University School of Medicine, Pediatrics
  • Sinai-Grace Hospital of Detroit, Internal Medicine

Medical School:

  • Cairo University School of Medicine

Research

Author Correction: Molecular bottlebrush prodrugs as mono- and triplex combination therapies for multiple myeloma. Nat Nanotechnol. 2023 Mar 13.
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Personalised progression prediction in patients with monoclonal gammopathy of undetermined significance or smouldering multiple myeloma (PANGEA): a retrospective, multicohort study. Lancet Haematol. 2023 Mar; 10(3):e203-e212.
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MinimuMM-seq: Genome Sequencing of Circulating Tumor Cells for Minimally Invasive Molecular Characterization of Multiple Myeloma Pathology. Cancer Discov. 2023 02 06; 13(2):348-363.
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Molecular bottlebrush prodrugs as mono- and triplex combination therapies for multiple myeloma. Nat Nanotechnol. 2023 02; 18(2):184-192.
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Single cell characterization of myeloma and its precursor conditions reveals transcriptional signatures of early tumorigenesis. Nat Commun. 2022 11 17; 13(1):7040.
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Immune biomarkers of response to immunotherapy in patients with high-risk smoldering myeloma. Cancer Cell. 2022 11 14; 40(11):1358-1373.e8.
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Simple Soft Tissue Biceps Tenodesis. Arthrosc Tech. 2022 Nov; 11(11):e1951-e1956.
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Kidney Organoids Generated Using an Allelic Series of NPHS2 Point Variants Reveal Distinct Intracellular Podocin Mistrafficking. J Am Soc Nephrol. 2023 01 01; 34(1):88-109.
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Single-cell multi-omics of human clonal hematopoiesis reveals that DNMT3A R882 mutations perturb early progenitor states through selective hypomethylation. Nat Genet. 2022 10; 54(10):1514-1526.
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The International Consensus Classification of Mature Lymphoid Neoplasms: a report from the Clinical Advisory Committee. Blood. 2022 09 15; 140(11):1229-1253.
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Quality of life, psychological distress, and prognostic perceptions in caregivers of patients with multiple myeloma. Blood Adv. 2022 09 13; 6(17):4967-4974.
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Multiple Myeloma With Amplification of Chr1q: Therapeutic Opportunity and Challenges. Front Oncol. 2022; 12:961421.
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Perspectives on the Risk-Stratified Treatment of Multiple Myeloma. Blood Cancer Discov. 2022 07 06; 3(4):273-284.
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Genetic subtypes of smoldering multiple myeloma are associated with distinct pathogenic phenotypes and clinical outcomes. Nat Commun. 2022 06 15; 13(1):3449.
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Triplet Therapy, Transplantation, and Maintenance until Progression in Myeloma. N Engl J Med. 2022 07 14; 387(2):132-147.
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Clonal hematopoiesis is associated with increased risk of progression of asymptomatic Waldenström macroglobulinemia. Blood Adv. 2022 04 12; 6(7):2230-2235.
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Prevalence of monoclonal gammopathies and clinical outcomes in a high-risk US population screened by mass spectrometry: a multicentre cohort study. Lancet Haematol. 2022 May; 9(5):e340-e349.
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Mass cytometry staining for human bone marrow clinical samples. STAR Protoc. 2022 03 18; 3(1):101163.
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Quality of life, psychological distress, and prognostic perceptions in patients with multiple myeloma. Cancer. 2022 05 15; 128(10):1996-2004.
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The emerging importance and evolving understanding of clonal hematopoiesis in multiple myeloma. Semin Oncol. 2022 02; 49(1):19-26.
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Single-cell profiling of tumour evolution in multiple myeloma - opportunities for precision medicine. Nat Rev Clin Oncol. 2022 04; 19(4):223-236.
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Attenuated response to SARS-CoV-2 vaccine in patients with asymptomatic precursor stages of multiple myeloma and Waldenstrom macroglobulinemia. Cancer Cell. 2022 01 10; 40(1):6-8.
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Regular Aspirin Use and Mortality in Patients with Multiple Myeloma. Cancer Epidemiol Biomarkers Prev. 2022 02; 31(2):479-485.
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Phase 1 study of ibrutinib and the CXCR4 antagonist ulocuplumab in CXCR4-mutated Waldenström macroglobulinemia. Blood. 2021 10 28; 138(17):1535-1539.
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Minimal Residual Disease in Myeloma: Application for Clinical Care and New Drug Registration. Clin Cancer Res. 2021 10 01; 27(19):5195-5212.
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ROBO1 Promotes Homing, Dissemination, and Survival of Multiple Myeloma within the Bone Marrow Microenvironment. Blood Cancer Discov. 2021 07; 2(4):338-353.
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The 2020 BMT CTN Myeloma Intergroup Workshop on Immune Profiling and Minimal Residual Disease Testing in Multiple Myeloma. Transplant Cell Ther. 2021 10; 27(10):807-816.
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Inflammatory stromal cells in the myeloma microenvironment. Nat Immunol. 2021 06; 22(6):677-678.
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Progression signature underlies clonal evolution and dissemination of multiple myeloma. Blood. 2021 04 29; 137(17):2360-2372.
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Autonomous Calcium Signaling in Human and Zebrafish Podocytes Controls Kidney Filtration Barrier Morphogenesis. J Am Soc Nephrol. 2021 Jul; 32(7):1697-1712.
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miR-15a/16-1 deletion in activated B cells promotes plasma cell and mature B-cell neoplasms. Blood. 2021 04 08; 137(14):1905-1919.
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Single-cell RNA sequencing: one step closer to the clinic. Nat Med. 2021 03; 27(3):375-376.
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Mapping the Degradable Kinome Provides a Resource for Expedited Degrader Development. Cell. 2020 12 10; 183(6):1714-1731.e10.
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An In Vitro Differentiation Protocol for Human Embryonic Bipotential Gonad and Testis Cell Development. Stem Cell Reports. 2020 12 08; 15(6):1377-1391.
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BELLINI: a renaissance for an era of precision therapy in multiple myeloma. Lancet Oncol. 2020 12; 21(12):1547-1549.
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Pregnancy outcomes, risk factors, and cell count trends in pregnant women with essential thrombocythemia. Leuk Res. 2020 11; 98:106459.
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Long-Term Follow-Up of Ibrutinib Monotherapy in Symptomatic, Previously Treated Patients With Waldenström Macroglobulinemia. J Clin Oncol. 2021 02 20; 39(6):565-575.
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Genome instability in multiple myeloma. Leukemia. 2020 11; 34(11):2887-2897.
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Pro-organic radical contrast agents ("pro-ORCAs") for real-time MRI of pro-drug activation in biological systems. Polym Chem. 2020 Aug 07; 11(29):4768-4779.
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Clonal hematopoiesis is associated with adverse outcomes in multiple myeloma patients undergoing transplant. Nat Commun. 2020 06 12; 11(1):2996.
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Monoclonal Gammopathy of Undetermined Significance (MGUS)-Not So Asymptomatic after All. Cancers (Basel). 2020 Jun 12; 12(6).
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Genomic Profiling of Smoldering Multiple Myeloma Identifies Patients at a High Risk of Disease Progression. J Clin Oncol. 2020 07 20; 38(21):2380-2389.
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The BTK inhibitor ibrutinib may protect against pulmonary injury in COVID-19-infected patients. Blood. 2020 05 21; 135(21):1912-1915.
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The COronavirus Pandemic Epidemiology (COPE) Consortium: A Call to Action. Cancer Epidemiol Biomarkers Prev. 2020 07; 29(7):1283-1289.
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Intensification and consolidation therapy in multiple myeloma in the current era. Lancet Haematol. 2020 06; 7(6):e427-e429.
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Single-cell RNA sequencing reveals compromised immune microenvironment in precursor stages of multiple myeloma. Nat Cancer. 2020 05; 1(5):493-506.
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Randomized, placebo-controlled, phase 3 study of perifosine combined with bortezomib and dexamethasone in patients with relapsed, refractory multiple myeloma previously treated with bortezomib. EJHaem. 2020 Jul; 1(1):94-102.
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Clinical Controversies in the Management of Smoldering Multiple Myeloma. Am Soc Clin Oncol Educ Book. 2020 Mar; 40:1-6.
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The microenvironment in myeloma. Curr Opin Oncol. 2020 03; 32(2):170-175.
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Bone marrow niches in haematological malignancies. Nat Rev Cancer. 2020 05; 20(5):285-298.
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Prediagnosis dietary pattern and survival in patients with multiple myeloma. Int J Cancer. 2020 10 01; 147(7):1823-1830.
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Genomic Landscape of Waldenström Macroglobulinemia and Its Impact on Treatment Strategies. J Clin Oncol. 2020 04 10; 38(11):1198-1208.
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Dissecting racial disparities in multiple myeloma. Blood Cancer J. 2020 02 17; 10(2):19.
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Circulating tumor markers: harmonizing the yin and yang of CTCs and ctDNA for precision medicine. Ann Oncol. 2019 Nov; 30(11):1845.
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Circulating tumor markers: harmonizing the yin and yang of CTCs and ctDNA for precision medicine. Ann Oncol. 2019 11 01; 30(11):1845.
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A Phase Ib/II Trial of the First-in-Class Anti-CXCR4 Antibody Ulocuplumab in Combination with Lenalidomide or Bortezomib Plus Dexamethasone in Relapsed Multiple Myeloma. Clin Cancer Res. 2020 01 15; 26(2):344-353.
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Antibody-targeting of ultra-small nanoparticles enhances imaging sensitivity and enables longitudinal tracking of multiple myeloma. Nanoscale. 2019 Nov 21; 11(43):20485-20496.
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Phase I/II trial of the CXCR4 inhibitor plerixafor in combination with bortezomib as a chemosensitization strategy in relapsed/refractory multiple myeloma. Am J Hematol. 2019 11; 94(11):1244-1253.
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Reply to F.D. Leonard. J Clin Oncol. 2019 10 10; 37(29):2701-2702.
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Fluorescence monitoring of rare circulating tumor cell and cluster dissemination in a multiple myeloma xenograft model in vivo. J Biomed Opt. 2019 08; 24(8):1-11.
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Correction: Resveratrol Exerts Antiproliferative Activity and Induces Apoptosis in Waldenström Macroglobulinemia. Clin Cancer Res. 2019 Aug 01; 25(15):4860.
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Author Correction: Mitochondrial metabolism promotes adaptation to proteotoxic stress. Nat Chem Biol. 2019 Jul; 15(7):757.
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Bone marrow niche in multiple myeloma and its precursor states. Hemasphere. 2019 Jun; 3(Suppl).
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Immunotherapy for hematological malignancies. J Life Sci (Westlake Village). 2019 Jun; 1(1):46-52.
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A Phase Ib/II Study of Oprozomib in Patients with Advanced Multiple Myeloma and Waldenström Macroglobulinemia. Clin Cancer Res. 2019 08 15; 25(16):4907-4916.
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Mitochondrial metabolism promotes adaptation to proteotoxic stress. Nat Chem Biol. 2019 07; 15(7):681-689.
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Dietary Pattern and Risk of Multiple Myeloma in Two Large Prospective US Cohort Studies. JNCI Cancer Spectr. 2019 Jun; 3(2):pkz025.
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Monoclonal gammopathy of undetermined significance. Blood. 2019 06 06; 133(23):2484-2494.
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Progression Risk Stratification of Asymptomatic Waldenström Macroglobulinemia. J Clin Oncol. 2019 06 01; 37(16):1403-1411.
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Citron Rho-interacting kinase silencing causes cytokinesis failure and reduces tumor growth in multiple myeloma. Blood Adv. 2019 04 09; 3(7):995-1002.
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Kidney micro-organoids in suspension culture as a scalable source of human pluripotent stem cell-derived kidney cells. Development. 2019 03 07; 146(5).
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Bone marrow biopsy in low-risk monoclonal gammopathy of undetermined significance reveals a novel smoldering multiple myeloma risk group. Am J Hematol. 2019 05; 94(5):E146-E149.
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Immunotherapy in Multiple Myeloma: Accelerating on the Path to the Patient. Clin Lymphoma Myeloma Leuk. 2019 06; 19(6):332-344.
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3D organoid-derived human glomeruli for personalised podocyte disease modelling and drug screening. Nat Commun. 2018 12 04; 9(1):5167.
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Autologous graft versus myeloma: it's not a myth. J Clin Invest. 2019 01 02; 129(1):48-50.
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Triply Loaded Nitroxide Brush-Arm Star Polymers Enable Metal-Free Millimetric Tumor Detection by Magnetic Resonance Imaging. ACS Nano. 2018 11 27; 12(11):11343-11354.
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Bortezomib overcomes the negative impact of CXCR4 mutations on survival of Waldenstrom macroglobulinemia patients. Blood. 2018 12 13; 132(24):2608-2612.
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Profiling of circulating exosomal miRNAs in patients with Waldenström Macroglobulinemia. PLoS One. 2018; 13(10):e0204589.
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A Phase I/II Study of Evofosfamide, A Hypoxia-activated Prodrug with or without Bortezomib in Subjects with Relapsed/Refractory Multiple Myeloma. Clin Cancer Res. 2019 01 15; 25(2):478-486.
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Acute lymphoblastic leukemia as a clonally unrelated second primary malignancy after multiple myeloma. Leukemia. 2019 01; 33(1):266-270.
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Inhibition of microRNA-138 enhances bone formation in multiple myeloma bone marrow niche. Leukemia. 2018 08; 32(8):1739-1750.
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Safety and immunogenicity of conjugate quadrivalent meningococcal vaccination after hematopoietic cell transplantation. Blood Adv. 2018 06 12; 2(11):1272-1276.
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Blocking IFNAR1 inhibits multiple myeloma-driven Treg expansion and immunosuppression. J Clin Invest. 2018 06 01; 128(6):2487-2499.
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A phase 2 study of modified lenalidomide, bortezomib and dexamethasone in transplant-ineligible multiple myeloma. Br J Haematol. 2018 07; 182(2):222-230.
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Whole-exome sequencing of cell-free DNA and circulating tumor cells in multiple myeloma. Nat Commun. 2018 04 27; 9(1):1691.
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Current use of monoclonal antibodies in the treatment of multiple myeloma. Br J Haematol. 2018 05; 181(4):447-459.
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Antibody-Dependent Cellular Phagocytosis by Macrophages is a Novel Mechanism of Action of Elotuzumab. Mol Cancer Ther. 2018 07; 17(7):1454-1463.
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Targeting MYC in multiple myeloma. Leukemia. 2018 06; 32(6):1295-1306.
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Platelets Enhance Multiple Myeloma Progression via IL-1ß Upregulation. Clin Cancer Res. 2018 05 15; 24(10):2430-2439.
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The bone-marrow niche in MDS and MGUS: implications for AML and MM. Nat Rev Clin Oncol. 2018 04; 15(4):219-233.
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Human regulatory T cells undergo self-inflicted damage via granzyme pathways upon activation. JCI Insight. 2017 11 02; 2(21).
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Metformin Affects Cortical Bone Mass and Marrow Adiposity in Diet-Induced Obesity in Male Mice. Endocrinology. 2017 10 01; 158(10):3369-3385.
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Bone Marrow Stroma and Vascular Contributions to Myeloma Bone Homing. Curr Osteoporos Rep. 2017 10; 15(5):499-506.
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A novel in vivo model for studying conditional dual loss of BLIMP-1 and p53 in B-cells, leading to tumor transformation. Am J Hematol. 2017 Aug; 92(8):E138-E145.
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IgM myeloma: A multicenter retrospective study of 134 patients. Am J Hematol. 2017 Aug; 92(8):746-751.
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The importance of the genomic landscape in Waldenström's Macroglobulinemia for targeted therapeutical interventions. Oncotarget. 2017 May 23; 8(21):35435-35444.
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Inhibiting the osteocyte-specific protein sclerostin increases bone mass and fracture resistance in multiple myeloma. Blood. 2017 06 29; 129(26):3452-3464.
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Inhibiting the oncogenic translation program is an effective therapeutic strategy in multiple myeloma. Sci Transl Med. 2017 05 10; 9(389).
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Serum IgM level as predictor of symptomatic hyperviscosity in patients with Waldenström macroglobulinaemia. Br J Haematol. 2017 06; 177(5):717-725.
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The Mutational Landscape of Circulating Tumor Cells in Multiple Myeloma. Cell Rep. 2017 04 04; 19(1):218-224.
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Proteomic characterization of human multiple myeloma bone marrow extracellular matrix. Leukemia. 2017 11; 31(11):2426-2434.
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Efficacy of the oral mTORC1 inhibitor everolimus in relapsed or refractory indolent lymphoma. Am J Hematol. 2017 May; 92(5):448-453.
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Circulating tumor markers: harmonizing the yin and yang of CTCs and ctDNA for precision medicine. Ann Oncol. 2017 03 01; 28(3):468-477.
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Prognostic role of circulating exosomal miRNAs in multiple myeloma. Blood. 2017 04 27; 129(17):2429-2436.
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Bone marrow stroma protects myeloma cells from cytotoxic damage via induction of the oncoprotein MUC1. Br J Haematol. 2017 03; 176(6):929-938.
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Established and Novel Prognostic Biomarkers in Multiple Myeloma. Am Soc Clin Oncol Educ Book. 2017; 37:548-560.
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Multiple Myeloma and the Immune Microenvironment. Curr Cancer Drug Targets. 2017; 17(9):806-818.
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Brief treatment with a highly selective immunoproteasome inhibitor promotes long-term cardiac allograft acceptance in mice. Proc Natl Acad Sci U S A. 2016 12 27; 113(52):E8425-E8432.
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Prospective, Multicenter Clinical Trial of Everolimus as Primary Therapy in Waldenstrom Macroglobulinemia (WMCTG 09-214). Clin Cancer Res. 2017 May 15; 23(10):2400-2404.
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The LIN28B/let-7 axis is a novel therapeutic pathway in multiple myeloma. Leukemia. 2017 04; 31(4):853-860.
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Epigenomics in Waldenstrom's macroglobulinaemia. Best Pract Res Clin Haematol. 2016 06; 29(2):156-160.
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Genomic complexity of multiple myeloma and its clinical implications. Nat Rev Clin Oncol. 2017 02; 14(2):100-113.
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Cell autonomous and microenvironmental regulation of tumor progression in precursor states of multiple myeloma. Curr Opin Hematol. 2016 07; 23(4):426-33.
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Management of refractory autoimmune hemolytic anemia via allogeneic stem cell transplantation. Bone Marrow Transplant. 2016 11; 51(11):1504-1506.
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TAK-228 (formerly MLN0128), an investigational oral dual TORC1/2 inhibitor: A phase I dose escalation study in patients with relapsed or refractory multiple myeloma, non-Hodgkin lymphoma, or Waldenström's macroglobulinemia. Am J Hematol. 2016 Jun; 91(4):400-5.
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The Use of Silk as a Scaffold for Mature, Sustainable Unilocular Adipose 3D Tissue Engineered Systems. Adv Healthc Mater. 2016 07; 5(13):1667-77.
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Myeloma Cell Dynamics in Response to Treatment Supports a Model of Hierarchical Differentiation and Clonal Evolution. Clin Cancer Res. 2016 Aug 15; 22(16):4206-4214.
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Response to ibrutinib in a patient with IgG lymphoplasmacytic lymphoma carrying the MYD88 L265P gene mutation. Leuk Lymphoma. 2016 11; 57(11):2699-701.
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Exome sequencing reveals recurrent germ line variants in patients with familial Waldenström macroglobulinemia. Blood. 2016 05 26; 127(21):2598-606.
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Targeting vasculogenesis to prevent progression in multiple myeloma. Leukemia. 2016 05; 30(5):1103-15.
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Cancer Cell Dissemination and Homing to the Bone Marrow in a Zebrafish Model. Cancer Res. 2016 Jan 15; 76(2):463-71.
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Exosomes in Tumor Angiogenesis. Methods Mol Biol. 2016; 1464:25-34.
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Epigenetics in Multiple Myeloma. Cancer Treat Res. 2016; 169:35-49.
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Genomic Aberrations in Multiple Myeloma. Cancer Treat Res. 2016; 169:23-34.
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Future Directions in the Evaluation and Treatment of Precursor Plasma Cell Disorders. Am Soc Clin Oncol Educ Book. 2016; 35:e400-6.
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Central nervous system involvement by Waldenström macroglobulinaemia (Bing-Neel syndrome): a multi-institutional retrospective study. Br J Haematol. 2016 Mar; 172(5):709-15.
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Targeting SDF-1 in multiple myeloma tumor microenvironment. Cancer Lett. 2016 09 28; 380(1):315-8.
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Waldenström's macroglobulinemia: a clinical perspective in the era of novel therapeutics. Ann Oncol. 2016 Feb; 27(2):233-40.
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Aberrant Levels of miRNAs in Bone Marrow Microenvironment and Peripheral Blood of Myeloma Patients and Disease Progression. J Mol Diagn. 2015 Nov; 17(6):669-78.
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Drug-Related Pneumonitis During Mammalian Target of Rapamycin Inhibitor Therapy: Radiographic Pattern-Based Approach in Waldenström Macroglobulinemia as a Paradigm. Oncologist. 2015 Sep; 20(9):1077-83.
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CXCR4 Regulates Extra-Medullary Myeloma through Epithelial-Mesenchymal-Transition-like Transcriptional Activation. Cell Rep. 2015 Jul 28; 12(4):622-35.
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Phase I/II trial of everolimus in combination with bortezomib and rituximab (RVR) in relapsed/refractory Waldenstrom macroglobulinemia. Leukemia. 2015 Dec; 29(12):2338-46.
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Development of extramedullary myeloma in the era of novel agents: no evidence of increased risk with lenalidomide-bortezomib combinations. Br J Haematol. 2015 Jun; 169(6):843-50.
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Biological properties of extracellular vesicles and their physiological functions. J Extracell Vesicles. 2015; 4:27066.
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Cyclophosphamide, bortezomib, and dexamethasone combination in waldenstrom macroglobulinemia. Am J Hematol. 2015 Jun; 90(6):E122-3.
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The road to cure in multiple myeloma starts with smoldering disease. Expert Opin Orphan Drugs. 2015 Apr 12; 3(6).
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Ibrutinib in previously treated Waldenström's macroglobulinemia. N Engl J Med. 2015 Apr 09; 372(15):1430-40.
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Incidence and clinical features of extramedullary multiple myeloma in patients who underwent stem cell transplantation. Br J Haematol. 2015 Jun; 169(6):851-8.
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American Society of Hematology Annual Meeting 2014: highlights in multiple myeloma. Expert Rev Hematol. 2015 Jun; 8(3):273-5.
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Metabolic signature identifies novel targets for drug resistance in multiple myeloma. Cancer Res. 2015 May 15; 75(10):2071-82.
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Dynamic interplay between bone and multiple myeloma: emerging roles of the osteoblast. Bone. 2015 Jun; 75:161-9.
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The cancer glycome: carbohydrates as mediators of metastasis. Blood Rev. 2015 Jul; 29(4):269-79.
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Biology, prognosis, and therapy of Waldenström Macroglobulinemia. Cancer Treat Res. 2015; 165:177-95.
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Targeting the bone marrow microenvironment in multiple myeloma. Immunol Rev. 2015 Jan; 263(1):160-72.
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Extramedullary Waldenström macroglobulinemia. Am J Hematol. 2015 Feb; 90(2):100-4.
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Global epigenetic regulation of microRNAs in multiple myeloma. PLoS One. 2014; 9(10):e110973.
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How I treat smoldering multiple myeloma. Blood. 2014 Nov 27; 124(23):3380-8.
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Team work matters: dual inhibition puts non-hodgkin lymphoma under siege. Clin Cancer Res. 2014 Dec 01; 20(23):5863-5.
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SDF-1 inhibition targets the bone marrow niche for cancer therapy. Cell Rep. 2014 Oct 09; 9(1):118-128.
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Hypoxia promotes dissemination and colonization in new bone marrow niches in Waldenström macroglobulinemia. Mol Cancer Res. 2015 Feb; 13(2):263-72.
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Pyk2 promotes tumor progression in multiple myeloma. Blood. 2014 Oct 23; 124(17):2675-86.
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Investigating osteogenic differentiation in multiple myeloma using a novel 3D bone marrow niche model. Blood. 2014 Nov 20; 124(22):3250-9.
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Targeting survival and cell trafficking in multiple myeloma and Waldenstrom macroglobulinemia using pan-class I PI3K inhibitor, buparlisib. Am J Hematol. 2014 Nov; 89(11):1030-6.
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The sialyltransferase ST3GAL6 influences homing and survival in multiple myeloma. Blood. 2014 Sep 11; 124(11):1765-76.
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Altered cytokine and chemokine profiles in multiple myeloma and its precursor disease. Cytokine. 2014 Oct; 69(2):294-7.
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Treatment recommendations for patients with Waldenström macroglobulinemia (WM) and related disorders: IWWM-7 consensus. Blood. 2014 Aug 28; 124(9):1404-11.
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Engineered nanomedicine for myeloma and bone microenvironment targeting. Proc Natl Acad Sci U S A. 2014 Jul 15; 111(28):10287-92.
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Clinical perspective: Linking psychosocial care to the disease continuum in patients with multiple myeloma. Palliat Support Care. 2015 Aug; 13(4):829-38.
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Biomarkers of bone remodeling in multiple myeloma patients to tailor bisphosphonate therapy. Clin Cancer Res. 2014 Aug 01; 20(15):3955-61.
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Carfilzomib, rituximab, and dexamethasone (CaRD) treatment offers a neuropathy-sparing approach for treating Waldenström's macroglobulinemia. Blood. 2014 Jul 24; 124(4):503-10.
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Outcomes in patients with relapsed or refractory multiple myeloma in a phase I study of everolimus in combination with lenalidomide. Br J Haematol. 2014 Aug; 166(3):401-9.
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Distinct roles of class I PI3K isoforms in multiple myeloma cell survival and dissemination. Blood Cancer J. 2014 Apr 25; 4:e204.
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C1013G/CXCR4 acts as a driver mutation of tumor progression and modulator of drug resistance in lymphoplasmacytic lymphoma. Blood. 2014 Jun 26; 123(26):4120-31.
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Role of endothelial progenitor cells in cancer progression. Biochim Biophys Acta. 2014 Aug; 1846(1):26-39.
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miR-630 targets IGF1R to regulate response to HER-targeting drugs and overall cancer cell progression in HER2 over-expressing breast cancer. Mol Cancer. 2014 Mar 24; 13:71.
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Long-term results of the phase II trial of the oral mTOR inhibitor everolimus (RAD001) in relapsed or refractory Waldenstrom Macroglobulinemia. Am J Hematol. 2014 Mar; 89(3):237-42.
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Regulation of microRNAs in cancer metastasis. Biochim Biophys Acta. 2014 Apr; 1845(2):255-65.
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A phase 2 trial of lenalidomide, bortezomib, and dexamethasone in patients with relapsed and relapsed/refractory myeloma. Blood. 2014 Mar 06; 123(10):1461-9.
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Waldenström macroglobulinemia: from biology to treatment. Expert Rev Hematol. 2014 Feb; 7(1):157-68.
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Biological and Clinical Implications of Clonal Heterogeneity and Clonal Evolution in Multiple Myeloma. Curr Cancer Ther Rev. 2014; 10(2):70-79.
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microRNA aberrations and their role in supporting hematologic malignancies. Microrna. 2014; 2(3):157.
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The role of miRNAs in plasma cell dyscrasias. Microrna. 2014; 2(3):165-73.
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Novel treatment options for Waldenström macroglobulinemia. Clin Lymphoma Myeloma Leuk. 2013 Sep; 13 Suppl 2:S310-6.
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Targeting apoptosis pathways in cancer therapy. CA Cancer J Clin. 2005 May-Jun; 55(3):178-94.
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Experimental design and analysis of antibody microarrays: applying methods from cDNA arrays. Cancer Res. 2005 Apr 15; 65(8):2985-9.
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Prognostic factors in patients with post-transplant lymphoproliferative disorders (PTLD) in the rituximab era. Leuk Lymphoma. 2005 Feb; 46(2):191-6.
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Differences between early and late posttransplant lymphoproliferative disorders in solid organ transplant patients: are they two different diseases? Transplantation. 2005 Jan 27; 79(2):244-7.
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Proteomic analysis of mantle-cell lymphoma by protein microarray. Blood. 2005 May 01; 105(9):3722-30.
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Role of the CXCR4 inhibitor AMD3100 in mulitple myeloma (MM). ASH. 2005.

Zoledronic acid inhibits CXCR-4-mediated prostate cancer cell invasion through an NFɻB independent pathway in vitro. AACR. 2005.

Proteomic Analysis of Multiple Myeloma Identifies Potential Targets for Drug Therapy. 10Th International Myeloma Workshop. 2005.

Molecular Mechanisms Involved in Homing and Migration of Plasma Cells in Response to CXCR4 Stimulation and Downstream Activation of The PI3K Pathway. 10Th International Myeloma Workshop. 2005.

The effect of rapamycin, 17-AAG and the combination on the bone marrow microenvironment in Multiple Myeloma (MM). ASH. 2005.

Proteomic analysis identifies differences in multiple myeloma (MM) cells sensitive and resistant to AKT inhibition. ASH. 2005.

The Role of CXCR4 inhibitors as Novel Antiangiogenesis Agents in Cancer Therapy. 10th Annyal Internation Myeloma Workshop. 2005.

Differential response to proteosome inhibition in EBV positive and negative lymphoma cell lines: clinical implications in post transplant lymphoproliferative disorders (PtLD). 2005.

Proteomic Analysis of Multiple Myeloma Identifies Potential Targets for Drug Therapy. 10th Annual Myeloma Workshop. 2005.

Role of cathepsin K in prostate cancer skeletal metastasis. AACR. 2005.

Combination of the AKT inhibitor perifosine with the HSP90 inhibitor 17-(dimethylaminoethyulamino)-17-demethoxygeldanamycin (17-DMAG) has synergistic activity in Multiple Myeloma (MM). ASH. 2005.

Zoledronic acid inhibits CXCR-4 mediated prostate cancer cell invasion through an NFE>>B independent pathway in vitro. AACR. 2005.

Combination of the mTOR inhibitor rapamycin with the HSP90 inhibitor 17-AAG has synergistic activity in EBV positive and negative post transplant lymphoproliferative disorders (PTLD). ASH. 2005.

Proteomic analysis of Waldenstrom Macroglobulinemia (WM) using nanoscale protein microarray techniques. ASH. 2005.

Role of cathepsin K in prostate cancer skeletal meastasis. AACR. 2005.

The Role of CXCR4 Inhibitors as Novel Antiangiogenesis Agents in Cancer Therapy. 10Th International Myeloma Workshop. 2005.

The role of the AKT inhibitor perifosine in migration and adhesion in multiple myeloma (MM). ASH. 2005.

Proteomic Analysis of Targeted Therapeutic Agents in Multiple Myeloma (MM). 10th International Myeloma Workshop. 2005.

Role of the chemokine receptor CXCR4 in Waldenstrom Macroglobulinemia. ASH. 2005.

Molecular mechanisms regulating migration and adhesion in response to the chemokine SDF-1 in multiple myeloma (MM). ASH. 2005.

Combination of the mTOR inhibitor Rapamycin and HSP90 inhibitor 17AAG in Multiple Myeloma. ASCO. 2005.

Proteomic analysis of post transplant lymphoproliferative disorders (PTLD) using nanoscale protein microarray techniques. ASH. 2005.

Initial immunoglobulin M 'flare' after rituximab therapy in patients diagnosed with Waldenstrom macroglobulinemia: an Eastern Cooperative Oncology Group Study. Cancer. 2004 Dec 01; 101(11):2593-8.
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Initial increase in the cryoglobulin level after rituximab therapy for type II cryoglobulinemia secondary to Waldenström macroglobulinemia does not indicate failure of response. Am J Hematol. 2004 Dec; 77(4):329-30.
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Proteomic analysis of patients with mantle cell lymphoma identifies Hsp90, and other proteins as potential target(s) for drug therapy. J Clin Oncol. 2004 Jul 15; 22(14_suppl):6530.
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Waldenström macroglobulinemia. Curr Treat Options Oncol. 2004 Jun; 5(3):239-47.
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High-dose intravenous methotrexate followed by autologous stem cell transplantation as a potentially effective therapy for neurolymphomatosis. Cancer. 2004 Jun 01; 100(11):2403-7.
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Radioimmunotherapy: a new treatment modality for B-cell non-Hodgkin's lymphoma. Oncology (Williston Park). 2004 May; 18(5):623-30; discussion 633-4, 637-8, 640.
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Expression of the chemokine receptors CXCR4 and CCR7 and disease progression in B-cell chronic lymphocytic leukemia/ small lymphocytic lymphoma. Mayo Clin Proc. 2004 Mar; 79(3):318-25.
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Fatal coronary artery disease after unrelated donor bone marrow transplantation. Mayo Clin Proc. 2004 Mar; 79(3):403-6.
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Therapeutic options in patients with lymphoma and severe liver dysfunction. Mayo Clin Proc. 2004 Feb; 79(2):169-75.
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Anti-Tumor Activity of Single-Agent CCI-779 for Relapsed Mantle Cell Lymphoma: A Phase II Trial in the North Central Cancer Treatment Group. ASH . 2004.

Molecular Mechanisms Involved in Homing and Migration of B-Chronic Lymphocytic Leukemia (CLL) in Response to CXCR4 Stimulation and Downstream Activation of the PI3K Pathway. ASH. 2004.

Proteomic Analysis of Waldenstrom Macroglobulinemia (WM) and IgM Monoclonal Gammopathy of Undetermined Significance (IgM-MGUS) Identifies Potential Targets for Drug Therapy. ASH. 2004.

The Role of CXCR4 Inhibitors as Novel Antiangiogenesis Agents in Cancer Therapy. ASH. 2004.

Experimental Design & Analysis of Protein Array Data: Applying Methods from cDNA Arrays. ASH. 2004.

Expression of the chemokine receptors CXCR4 and CCR7 and disease progression in B-cell chronic lymphocytic leukemia/ small lymphocytic lymphoma. National Institute of Health. 2004.

Proteomic analysis of mantle cell lymphoma. National Institute of Health. 2004.

Proteomic analysis of patients with mantle cell lymphoma identifies Hsp90 and other proteins as potential target(s) for drug therapy. ASCO. 2004.

Proteomic Analysis of Multiple Myeloma Identifies Potential Targets for Drug Therapy . ASH. 2004.

Proteomic Analysis of Targeted Therapeutic Agents in Multiple Myeloma (MM). ASH. 2004.

Molecular Mechanisms Involved in Homing and Migration of Plasma Cells in Response to CXCR4 Stimulation and Downstream Activation of The PI3K Pathway. ASH. 2004.

Characterization of Waldenström Macroglobulinemia Subtypes Using Global Gene Expression Profiling. ASH. 2004.

CCI-779 inhibits phosphorylation of ribosomal S6 (pS6) in mantle cell lymphoma. AACR. 2004.

Renal cell carcinoma with acrometastasis and scalp metastasis. Mayo Clin Proc. 2004 Jan; 79(1):76.
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An EBV-positive lymphoproliferative disorder after therapy with alemtuzumab. N Engl J Med. 2003 Dec 25; 349(26):2570-2; discussion 2570-2.
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Waldenström macroglobulinaemia. Lancet Oncol. 2003 Nov; 4(11):679-85.
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Management of thalidomide toxicity. J Support Oncol. 2003 Sep-Oct; 1(3):194-205.
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Effect of thalidomide on stem cell collection and engraftment in patients with multiple myeloma. Bone Marrow Transplant. 2003 Sep; 32(6):587-92.
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Rituximab and IPI are prognostic indicators in post transplant lymphoproliferative disorders (PTLD). American Society of Clinical Oncology. 2003.

Prognostic model for patients with Post Transplant Lymphoproliferative Disorders. Blood. 2003.

The IgM flare in patients diagnosed with Waldenstrom Macroglobulinemia and treated with rituximab: an ECOG study. Blood. 2003.

CNS Post Transplant Lymphoproliferative Disorders: therapy with rituximab. Blood. 2003.

Expression of the chemokine receptors CXCR4 and CCR7 and disease progression in B-cell chronic lymphocytic leukemia/small lymphocytic lymphoma. Panpacific Lymphoma Conference. 2003.

Differences between early and late Post Transplant Lymphoproliferative Disorders: are they two different diseases. Blood. 2003.

Prognostic model for 506 patients diagnosed with Waldenstrom Macroglobulinemia,. Blood. 2003.

Therapeutic options in patients with lymphoma and severe liver dysfunction. Blood. 2003.

Deletions of 6q predominantly involve band q23 and distinguish Waldenström macroglobulinemia from IgM monoclonal gammopathy of undetermined significance. Blood. 2003.

Subcutaneous Panniculitis-like T cell lymphoma: clinical presentation and follow up of 17 patients. Blood. 2003.

Inhibitors of the ras oncogene as therapeutic targets. Hematol Oncol Clin North Am. 2002 Oct; 16(5):1065-88.
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T-cell activation and lymphokine production induced by antihuman CD3 monoclonal antibodies. Transplant Proc. 1991 Feb; 23(1 Pt 1):81-2.
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The mechanism of anti-CD3 monoclonal antibodies. Mediation of cytolysis by inter-T cell bridging. Transplantation. 1990 Oct; 50(4):683-9.
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T cells in patients undergoing chronic hemodialysis: mitogenic response, suppressor activity, and interleukin-2 production and receptor generation. Diagn Immunol. 1986; 4(4):209-16.
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