Irene Ghobrial, MD

Irene Ghobrial, MD

Medical Oncology

Contact Information

Office Phone Number

617-632-4218

Fax

617-751-7082

Appointments

617-632-3823 (new)

Biography

Irene Ghobrial, MD

Dr. Ghobrial is the Senior Vice President for Experimental Medicine, Director of the Center for Early Detection and Interception of Blood Cancers, Co-Leader of the Lymphoma/Myeloma Cancer Center Program, Lavine Family Chair for Preventative Cancer Therapies, Director of the Ghobrial Lab, and Professor of Medicine at Dana-Farber Cancer Institute and Harvard Medical School.

Her research focuses on precursor conditions of multiple myeloma, aiming to understand genetic, epigenetic, and immune mechanisms of disease progression, identify novel biomarkers, and develop therapies to eliminate disease before progression. She has led 15+ clinical trials in Waldenstrom macroglobulinemia and multiple myeloma precursor conditions.  

Dr. Ghobrial received her MD in 1995 from Cairo University School of Medicine, Egypt.  She completed her Internal Medicine training at Wayne State University, Mich., and her Hematology/Oncology subspecialty training at Mayo Clinic College of Medicine, Minn.  She joined Dana-Farber in the field of Waldenstrom's macroglobulinemia and multiple myeloma in 2005.

Researcher

Physician

Director of Center for Early Detection and Interception of Blood Cancers
Director, Clinical Investigator Research Program
Lavine Family Chair for Preventative Cancer Therapies
Professor of Medicine, Harvard Medical School

Centers/Programs

Multiple Myeloma Program
Stem Cell Transplantation
Waldenström’s Macroglobulinemia

Clinical Interests

Multiple myeloma, Waldenström’s Macroglobulinemia

Board Certification

  • Hematology, 2004
  • Internal Medicine, 2001
  • Medical Oncology, 2004

Fellowship

  • Mayo Clinic, Graduate Medical Education, Hematology & Oncology

Residency

  • Cairo University School of Medicine, Pediatrics
  • Sinai-Grace Hospital of Detroit, Internal Medicine

Medical School

  • Cairo University School of Medicine

Recent Awards

  • Jan Gosta Waldenstrom Award, International Workshop on Waldenstrom’s Macroglobulinemia
  • National Cancer Institute Outstanding Investigator Award
  • William Dameshek Prize, American Society of Hematology

Publications

    • Editor's Note: Targeting Akt and Heat Shock Protein 90 Produces Synergistic Multiple Myeloma Cell Cytotoxicity in the Bone Marrow Microenvironment. Clin Cancer Res. 2024 Feb 16; 30(4):922. View in: Pubmed

    • Editor's Note: Mechanisms of Activity of the TORC1 Inhibitor Everolimus in Waldenstrom Macroglobulinemia. Clin Cancer Res. 2024 Feb 16; 30(4):919. View in: Pubmed

    • Editor's Note: Eph-B2/Ephrin-B2 Interaction Plays a Major Role in the Adhesion and Proliferation of Waldenstrom's Macroglobulinemia. Clin Cancer Res. 2024 Feb 16; 30(4):920. View in: Pubmed

    • Mass spectrometry-detected MGUS is associated with obesity and other novel modifiable risk factors in a high-risk population. Blood Adv. 2024 Jan 11. View in: Pubmed

    • Clinical Outcomes and Evolution of Clonal Hematopoiesis in Patients with Newly Diagnosed Multiple Myeloma. Cancer Res Commun. 2023 Dec 18; 3(12):2560-2571. View in: Pubmed

    • Author Correction: Molecular bottlebrush prodrugs as mono- and triplex combination therapies for multiple myeloma. Nat Nanotechnol. 2023 Sep; 18(9):1116. View in: Pubmed

    • Single-cell multi-omics defines the cell-type-specific impact of splicing aberrations in human hematopoietic clonal outgrowths. Cell Stem Cell. 2023 09 07; 30(9):1262-1281.e8. View in: Pubmed

    • Systematic characterization of therapeutic vulnerabilities in Multiple Myeloma with Amp1q reveals increased sensitivity to the combination of MCL1 and PI3K inhibitors. bioRxiv. 2023 Aug 03. View in: Pubmed

    • Monoclonal B-cell lymphocytosis, monoclonal gammopathy of undetermined significance, and T-cell clones of uncertain significance: are these premalignant conditions sharing a common identity? Lancet Haematol. 2023 Jul; 10(7):e549-e556. View in: Pubmed

    • Selective Enhancer Dependencies in MYC -Intact and MYC -Rearranged Germinal Center B-cell Diffuse Large B-cell Lymphoma. bioRxiv. 2023 May 03. View in: Pubmed

    • Author Correction: Molecular bottlebrush prodrugs as mono- and triplex combination therapies for multiple myeloma. Nat Nanotechnol. 2023 Apr; 18(4):419. View in: Pubmed

    • Personalised progression prediction in patients with monoclonal gammopathy of undetermined significance or smouldering multiple myeloma (PANGEA): a retrospective, multicohort study. Lancet Haematol. 2023 Mar; 10(3):e203-e212. View in: Pubmed

    • Diagnostic TR-FRET assays for detection of antibodies in patient samples. Cell Rep Methods. 2023 03 27; 3(3):100421. View in: Pubmed

    • MinimuMM-seq: Genome Sequencing of Circulating Tumor Cells for Minimally Invasive Molecular Characterization of Multiple Myeloma Pathology. Cancer Discov. 2023 02 06; 13(2):348-363. View in: Pubmed

    • Molecular bottlebrush prodrugs as mono- and triplex combination therapies for multiple myeloma. Nat Nanotechnol. 2023 02; 18(2):184-192. View in: Pubmed

    • Single cell characterization of myeloma and its precursor conditions reveals transcriptional signatures of early tumorigenesis. Nat Commun. 2022 Nov 17; 13(1):7040. View in: Pubmed

    • Immune biomarkers of response to immunotherapy in patients with high-risk smoldering myeloma. Cancer Cell. 2022 11 14; 40(11):1358-1373.e8. View in: Pubmed

    • Simple Soft Tissue Biceps Tenodesis. Arthrosc Tech. 2022 Nov; 11(11):e1951-e1956. View in: Pubmed

    • Kidney Organoids Generated Using an Allelic Series of NPHS2 Point Variants Reveal Distinct Intracellular Podocin Mistrafficking. J Am Soc Nephrol. 2023 01 01; 34(1):88-109. View in: Pubmed

    • Single-cell multi-omics of human clonal hematopoiesis reveals that DNMT3A R882 mutations perturb early progenitor states through selective hypomethylation. Nat Genet. 2022 10; 54(10):1514-1526. View in: Pubmed

    • The International Consensus Classification of Mature Lymphoid Neoplasms: a report from the Clinical Advisory Committee. Blood. 2022 09 15; 140(11):1229-1253. View in: Pubmed

    • Quality of life, psychological distress, and prognostic perceptions in caregivers of patients with multiple myeloma. Blood Adv. 2022 09 13; 6(17):4967-4974. View in: Pubmed

    • Multiple Myeloma With Amplification of Chr1q: Therapeutic Opportunity and Challenges. Front Oncol. 2022; 12:961421. View in: Pubmed

    • Perspectives on the Risk-Stratified Treatment of Multiple Myeloma. Blood Cancer Discov. 2022 07 06; 3(4):273-284. View in: Pubmed

    • Genetic subtypes of smoldering multiple myeloma are associated with distinct pathogenic phenotypes and clinical outcomes. Nat Commun. 2022 06 15; 13(1):3449. View in: Pubmed

    • Triplet Therapy, Transplantation, and Maintenance until Progression in Myeloma. N Engl J Med. 2022 07 14; 387(2):132-147. View in: Pubmed

    • Clonal hematopoiesis is associated with increased risk of progression of asymptomatic Waldenström macroglobulinemia. Blood Adv. 2022 04 12; 6(7):2230-2235. View in: Pubmed

    • Prevalence of monoclonal gammopathies and clinical outcomes in a high-risk US population screened by mass spectrometry: a multicentre cohort study. Lancet Haematol. 2022 May; 9(5):e340-e349. View in: Pubmed

    • Mass cytometry staining for human bone marrow clinical samples. STAR Protoc. 2022 03 18; 3(1):101163. View in: Pubmed

    • Quality of life, psychological distress, and prognostic perceptions in patients with multiple myeloma. Cancer. 2022 05 15; 128(10):1996-2004. View in: Pubmed

    • The emerging importance and evolving understanding of clonal hematopoiesis in multiple myeloma. Semin Oncol. 2022 02; 49(1):19-26. View in: Pubmed

    • Single-cell profiling of tumour evolution in multiple myeloma - opportunities for precision medicine. Nat Rev Clin Oncol. 2022 04; 19(4):223-236. View in: Pubmed

    • Attenuated response to SARS-CoV-2 vaccine in patients with asymptomatic precursor stages of multiple myeloma and Waldenstrom macroglobulinemia. Cancer Cell. 2022 01 10; 40(1):6-8. View in: Pubmed

    • Regular Aspirin Use and Mortality in Patients with Multiple Myeloma. Cancer Epidemiol Biomarkers Prev. 2022 02; 31(2):479-485. View in: Pubmed

    • Phase 1 study of ibrutinib and the CXCR4 antagonist ulocuplumab in CXCR4-mutated Waldenström macroglobulinemia. Blood. 2021 10 28; 138(17):1535-1539. View in: Pubmed

    • Minimal Residual Disease in Myeloma: Application for Clinical Care and New Drug Registration. Clin Cancer Res. 2021 10 01; 27(19):5195-5212. View in: Pubmed

    • ROBO1 Promotes Homing, Dissemination, and Survival of Multiple Myeloma within the Bone Marrow Microenvironment. Blood Cancer Discov. 2021 07; 2(4):338-353. View in: Pubmed

    • The 2020 BMT CTN Myeloma Intergroup Workshop on Immune Profiling and Minimal Residual Disease Testing in Multiple Myeloma. Transplant Cell Ther. 2021 10; 27(10):807-816. View in: Pubmed

    • Inflammatory stromal cells in the myeloma microenvironment. Nat Immunol. 2021 06; 22(6):677-678. View in: Pubmed

    • Progression signature underlies clonal evolution and dissemination of multiple myeloma. Blood. 2021 04 29; 137(17):2360-2372. View in: Pubmed

    • Autonomous Calcium Signaling in Human and Zebrafish Podocytes Controls Kidney Filtration Barrier Morphogenesis. J Am Soc Nephrol. 2021 Jul; 32(7):1697-1712. View in: Pubmed

    • miR-15a/16-1 deletion in activated B cells promotes plasma cell and mature B-cell neoplasms. Blood. 2021 04 08; 137(14):1905-1919. View in: Pubmed

    • Single-cell RNA sequencing: one step closer to the clinic. Nat Med. 2021 03; 27(3):375-376. View in: Pubmed

    • Mapping the Degradable Kinome Provides a Resource for Expedited Degrader Development. Cell. 2020 12 10; 183(6):1714-1731.e10. View in: Pubmed

    • An In Vitro Differentiation Protocol for Human Embryonic Bipotential Gonad and Testis Cell Development. Stem Cell Reports. 2020 12 08; 15(6):1377-1391. View in: Pubmed

    • BELLINI: a renaissance for an era of precision therapy in multiple myeloma. Lancet Oncol. 2020 12; 21(12):1547-1549. View in: Pubmed

    • Pregnancy outcomes, risk factors, and cell count trends in pregnant women with essential thrombocythemia. Leuk Res. 2020 11; 98:106459. View in: Pubmed

    • Long-Term Follow-Up of Ibrutinib Monotherapy in Symptomatic, Previously Treated Patients With Waldenström Macroglobulinemia. J Clin Oncol. 2021 02 20; 39(6):565-575. View in: Pubmed

    • Genome instability in multiple myeloma. Leukemia. 2020 11; 34(11):2887-2897. View in: Pubmed

    • Pro-organic radical contrast agents ("pro-ORCAs") for real-time MRI of pro-drug activation in biological systems. Polym Chem. 2020 Aug 07; 11(29):4768-4779. View in: Pubmed

    • Clonal hematopoiesis is associated with adverse outcomes in multiple myeloma patients undergoing transplant. Nat Commun. 2020 06 12; 11(1):2996. View in: Pubmed

    • Monoclonal Gammopathy of Undetermined Significance (MGUS)-Not So Asymptomatic after All. Cancers (Basel). 2020 Jun 12; 12(6). View in: Pubmed

    • Genomic Profiling of Smoldering Multiple Myeloma Identifies Patients at a High Risk of Disease Progression. J Clin Oncol. 2020 07 20; 38(21):2380-2389. View in: Pubmed

    • The BTK inhibitor ibrutinib may protect against pulmonary injury in COVID-19-infected patients. Blood. 2020 05 21; 135(21):1912-1915. View in: Pubmed

    • The COronavirus Pandemic Epidemiology (COPE) Consortium: A Call to Action. Cancer Epidemiol Biomarkers Prev. 2020 07; 29(7):1283-1289. View in: Pubmed

    • Intensification and consolidation therapy in multiple myeloma in the current era. Lancet Haematol. 2020 06; 7(6):e427-e429. View in: Pubmed

    • Single-cell RNA sequencing reveals compromised immune microenvironment in precursor stages of multiple myeloma. Nat Cancer. 2020 05; 1(5):493-506. View in: Pubmed

    • Randomized, placebo-controlled, phase 3 study of perifosine combined with bortezomib and dexamethasone in patients with relapsed, refractory multiple myeloma previously treated with bortezomib. EJHaem. 2020 Jul; 1(1):94-102. View in: Pubmed

    • Clinical Controversies in the Management of Smoldering Multiple Myeloma. Am Soc Clin Oncol Educ Book. 2020 Mar; 40:1-6. View in: Pubmed

    • The microenvironment in myeloma. Curr Opin Oncol. 2020 03; 32(2):170-175. View in: Pubmed

    • Bone marrow niches in haematological malignancies. Nat Rev Cancer. 2020 05; 20(5):285-298. View in: Pubmed

    • Prediagnosis dietary pattern and survival in patients with multiple myeloma. Int J Cancer. 2020 10 01; 147(7):1823-1830. View in: Pubmed

    • Genomic Landscape of Waldenström Macroglobulinemia and Its Impact on Treatment Strategies. J Clin Oncol. 2020 04 10; 38(11):1198-1208. View in: Pubmed

    • Dissecting racial disparities in multiple myeloma. Blood Cancer J. 2020 02 17; 10(2):19. View in: Pubmed

    • Circulating tumor markers: harmonizing the yin and yang of CTCs and ctDNA for precision medicine. Ann Oncol. 2019 Nov; 30(11):1845. View in: Pubmed

    • Circulating tumor markers: harmonizing the yin and yang of CTCs and ctDNA for precision medicine. Ann Oncol. 2019 11 01; 30(11):1845. View in: Pubmed

    • A Phase Ib/II Trial of the First-in-Class Anti-CXCR4 Antibody Ulocuplumab in Combination with Lenalidomide or Bortezomib Plus Dexamethasone in Relapsed Multiple Myeloma. Clin Cancer Res. 2020 01 15; 26(2):344-353. View in: Pubmed

    • Antibody-targeting of ultra-small nanoparticles enhances imaging sensitivity and enables longitudinal tracking of multiple myeloma. Nanoscale. 2019 Nov 21; 11(43):20485-20496. View in: Pubmed

    • Phase I/II trial of the CXCR4 inhibitor plerixafor in combination with bortezomib as a chemosensitization strategy in relapsed/refractory multiple myeloma. Am J Hematol. 2019 11; 94(11):1244-1253. View in: Pubmed

    • Reply to F.D. Leonard. J Clin Oncol. 2019 10 10; 37(29):2701-2702. View in: Pubmed

    • Fluorescence monitoring of rare circulating tumor cell and cluster dissemination in a multiple myeloma xenograft model in vivo. J Biomed Opt. 2019 08; 24(8):1-11. View in: Pubmed

    • Correction: Resveratrol Exerts Antiproliferative Activity and Induces Apoptosis in Waldenström Macroglobulinemia. Clin Cancer Res. 2019 Aug 01; 25(15):4860. View in: Pubmed

    • Author Correction: Mitochondrial metabolism promotes adaptation to proteotoxic stress. Nat Chem Biol. 2019 Jul; 15(7):757. View in: Pubmed

    • Bone marrow niche in multiple myeloma and its precursor states. Hemasphere. 2019 Jun; 3(Suppl). View in: Pubmed

    • Immunotherapy for hematological malignancies. J Life Sci (Westlake Village). 2019 Jun; 1(1):46-52. View in: Pubmed

    • A Phase Ib/II Study of Oprozomib in Patients with Advanced Multiple Myeloma and Waldenström Macroglobulinemia. Clin Cancer Res. 2019 08 15; 25(16):4907-4916. View in: Pubmed

    • Mitochondrial metabolism promotes adaptation to proteotoxic stress. Nat Chem Biol. 2019 07; 15(7):681-689. View in: Pubmed

    • Dietary Pattern and Risk of Multiple Myeloma in Two Large Prospective US Cohort Studies. JNCI Cancer Spectr. 2019 Jun; 3(2):pkz025. View in: Pubmed

    • Monoclonal gammopathy of undetermined significance. Blood. 2019 06 06; 133(23):2484-2494. View in: Pubmed

    • Progression Risk Stratification of Asymptomatic Waldenström Macroglobulinemia. J Clin Oncol. 2019 06 01; 37(16):1403-1411. View in: Pubmed

    • Citron Rho-interacting kinase silencing causes cytokinesis failure and reduces tumor growth in multiple myeloma. Blood Adv. 2019 04 09; 3(7):995-1002. View in: Pubmed

    • Kidney micro-organoids in suspension culture as a scalable source of human pluripotent stem cell-derived kidney cells. Development. 2019 03 07; 146(5). View in: Pubmed

    • Bone marrow biopsy in low-risk monoclonal gammopathy of undetermined significance reveals a novel smoldering multiple myeloma risk group. Am J Hematol. 2019 05; 94(5):E146-E149. View in: Pubmed

    • Immunotherapy in Multiple Myeloma: Accelerating on the Path to the Patient. Clin Lymphoma Myeloma Leuk. 2019 06; 19(6):332-344. View in: Pubmed

    • 3D organoid-derived human glomeruli for personalised podocyte disease modelling and drug screening. Nat Commun. 2018 12 04; 9(1):5167. View in: Pubmed

    • Autologous graft versus myeloma: it's not a myth. J Clin Invest. 2019 01 02; 129(1):48-50. View in: Pubmed

    • Triply Loaded Nitroxide Brush-Arm Star Polymers Enable Metal-Free Millimetric Tumor Detection by Magnetic Resonance Imaging. ACS Nano. 2018 11 27; 12(11):11343-11354. View in: Pubmed

    • Bortezomib overcomes the negative impact of CXCR4 mutations on survival of Waldenstrom macroglobulinemia patients. Blood. 2018 12 13; 132(24):2608-2612. View in: Pubmed

    • Profiling of circulating exosomal miRNAs in patients with Waldenström Macroglobulinemia. PLoS One. 2018; 13(10):e0204589. View in: Pubmed

    • A Phase I/II Study of Evofosfamide, A Hypoxia-activated Prodrug with or without Bortezomib in Subjects with Relapsed/Refractory Multiple Myeloma. Clin Cancer Res. 2019 01 15; 25(2):478-486. View in: Pubmed

    • Acute lymphoblastic leukemia as a clonally unrelated second primary malignancy after multiple myeloma. Leukemia. 2019 01; 33(1):266-270. View in: Pubmed

    • Inhibition of microRNA-138 enhances bone formation in multiple myeloma bone marrow niche. Leukemia. 2018 08; 32(8):1739-1750. View in: Pubmed

    • Safety and immunogenicity of conjugate quadrivalent meningococcal vaccination after hematopoietic cell transplantation. Blood Adv. 2018 06 12; 2(11):1272-1276. View in: Pubmed

    • Blocking IFNAR1 inhibits multiple myeloma-driven Treg expansion and immunosuppression. J Clin Invest. 2018 06 01; 128(6):2487-2499. View in: Pubmed

    • A phase 2 study of modified lenalidomide, bortezomib and dexamethasone in transplant-ineligible multiple myeloma. Br J Haematol. 2018 07; 182(2):222-230. View in: Pubmed

    • Whole-exome sequencing of cell-free DNA and circulating tumor cells in multiple myeloma. Nat Commun. 2018 04 27; 9(1):1691. View in: Pubmed

    • Current use of monoclonal antibodies in the treatment of multiple myeloma. Br J Haematol. 2018 05; 181(4):447-459. View in: Pubmed

    • Antibody-Dependent Cellular Phagocytosis by Macrophages is a Novel Mechanism of Action of Elotuzumab. Mol Cancer Ther. 2018 07; 17(7):1454-1463. View in: Pubmed

    • Targeting MYC in multiple myeloma. Leukemia. 2018 06; 32(6):1295-1306. View in: Pubmed

    • Platelets Enhance Multiple Myeloma Progression via IL-1ß Upregulation. Clin Cancer Res. 2018 05 15; 24(10):2430-2439. View in: Pubmed

    • The bone-marrow niche in MDS and MGUS: implications for AML and MM. Nat Rev Clin Oncol. 2018 04; 15(4):219-233. View in: Pubmed

    • Human regulatory T cells undergo self-inflicted damage via granzyme pathways upon activation. JCI Insight. 2017 11 02; 2(21). View in: Pubmed

    • Metformin Affects Cortical Bone Mass and Marrow Adiposity in Diet-Induced Obesity in Male Mice. Endocrinology. 2017 10 01; 158(10):3369-3385. View in: Pubmed

    • Bone Marrow Stroma and Vascular Contributions to Myeloma Bone Homing. Curr Osteoporos Rep. 2017 10; 15(5):499-506. View in: Pubmed

    • A novel in vivo model for studying conditional dual loss of BLIMP-1 and p53 in B-cells, leading to tumor transformation. Am J Hematol. 2017 Aug; 92(8):E138-E145. View in: Pubmed

    • IgM myeloma: A multicenter retrospective study of 134 patients. Am J Hematol. 2017 Aug; 92(8):746-751. View in: Pubmed

    • The importance of the genomic landscape in Waldenström's Macroglobulinemia for targeted therapeutical interventions. Oncotarget. 2017 May 23; 8(21):35435-35444. View in: Pubmed

    • Inhibiting the osteocyte-specific protein sclerostin increases bone mass and fracture resistance in multiple myeloma. Blood. 2017 06 29; 129(26):3452-3464. View in: Pubmed

    • Inhibiting the oncogenic translation program is an effective therapeutic strategy in multiple myeloma. Sci Transl Med. 2017 05 10; 9(389). View in: Pubmed

    • Serum IgM level as predictor of symptomatic hyperviscosity in patients with Waldenström macroglobulinaemia. Br J Haematol. 2017 06; 177(5):717-725. View in: Pubmed

    • The Mutational Landscape of Circulating Tumor Cells in Multiple Myeloma. Cell Rep. 2017 04 04; 19(1):218-224. View in: Pubmed

    • Proteomic characterization of human multiple myeloma bone marrow extracellular matrix. Leukemia. 2017 11; 31(11):2426-2434. View in: Pubmed

    • Efficacy of the oral mTORC1 inhibitor everolimus in relapsed or refractory indolent lymphoma. Am J Hematol. 2017 May; 92(5):448-453. View in: Pubmed

    • Circulating tumor markers: harmonizing the yin and yang of CTCs and ctDNA for precision medicine. Ann Oncol. 2017 03 01; 28(3):468-477. View in: Pubmed

    • Prognostic role of circulating exosomal miRNAs in multiple myeloma. Blood. 2017 04 27; 129(17):2429-2436. View in: Pubmed

    • Bone marrow stroma protects myeloma cells from cytotoxic damage via induction of the oncoprotein MUC1. Br J Haematol. 2017 03; 176(6):929-938. View in: Pubmed

    • Established and Novel Prognostic Biomarkers in Multiple Myeloma. Am Soc Clin Oncol Educ Book. 2017; 37:548-560. View in: Pubmed

    • Multiple Myeloma and the Immune Microenvironment. Curr Cancer Drug Targets. 2017; 17(9):806-818. View in: Pubmed

    • Brief treatment with a highly selective immunoproteasome inhibitor promotes long-term cardiac allograft acceptance in mice. Proc Natl Acad Sci U S A. 2016 12 27; 113(52):E8425-E8432. View in: Pubmed

    • Prospective, Multicenter Clinical Trial of Everolimus as Primary Therapy in Waldenstrom Macroglobulinemia (WMCTG 09-214). Clin Cancer Res. 2017 May 15; 23(10):2400-2404. View in: Pubmed

    • The LIN28B/let-7 axis is a novel therapeutic pathway in multiple myeloma. Leukemia. 2017 04; 31(4):853-860. View in: Pubmed

    • Epigenomics in Waldenstrom's macroglobulinaemia. Best Pract Res Clin Haematol. 2016 06; 29(2):156-160. View in: Pubmed

    • Genomic complexity of multiple myeloma and its clinical implications. Nat Rev Clin Oncol. 2017 02; 14(2):100-113. View in: Pubmed

    • Cell autonomous and microenvironmental regulation of tumor progression in precursor states of multiple myeloma. Curr Opin Hematol. 2016 07; 23(4):426-33. View in: Pubmed

    • Management of refractory autoimmune hemolytic anemia via allogeneic stem cell transplantation. Bone Marrow Transplant. 2016 11; 51(11):1504-1506. View in: Pubmed

    • TAK-228 (formerly MLN0128), an investigational oral dual TORC1/2 inhibitor: A phase I dose escalation study in patients with relapsed or refractory multiple myeloma, non-Hodgkin lymphoma, or Waldenström's macroglobulinemia. Am J Hematol. 2016 Jun; 91(4):400-5. View in: Pubmed

    • The Use of Silk as a Scaffold for Mature, Sustainable Unilocular Adipose 3D Tissue Engineered Systems. Adv Healthc Mater. 2016 07; 5(13):1667-77. View in: Pubmed

    • Myeloma Cell Dynamics in Response to Treatment Supports a Model of Hierarchical Differentiation and Clonal Evolution. Clin Cancer Res. 2016 Aug 15; 22(16):4206-4214. View in: Pubmed

    • Response to ibrutinib in a patient with IgG lymphoplasmacytic lymphoma carrying the MYD88 L265P gene mutation. Leuk Lymphoma. 2016 11; 57(11):2699-701. View in: Pubmed

    • Exome sequencing reveals recurrent germ line variants in patients with familial Waldenström macroglobulinemia. Blood. 2016 05 26; 127(21):2598-606. View in: Pubmed

    • Targeting vasculogenesis to prevent progression in multiple myeloma. Leukemia. 2016 05; 30(5):1103-15. View in: Pubmed

    • Cancer Cell Dissemination and Homing to the Bone Marrow in a Zebrafish Model. Cancer Res. 2016 Jan 15; 76(2):463-71. View in: Pubmed

    • Exosomes in Tumor Angiogenesis. Methods Mol Biol. 2016; 1464:25-34. View in: Pubmed

    • Epigenetics in Multiple Myeloma. Cancer Treat Res. 2016; 169:35-49. View in: Pubmed

    • Genomic Aberrations in Multiple Myeloma. Cancer Treat Res. 2016; 169:23-34. View in: Pubmed

    • Future Directions in the Evaluation and Treatment of Precursor Plasma Cell Disorders. Am Soc Clin Oncol Educ Book. 2016; 35:e400-6. View in: Pubmed

    • Central nervous system involvement by Waldenström macroglobulinaemia (Bing-Neel syndrome): a multi-institutional retrospective study. Br J Haematol. 2016 Mar; 172(5):709-15. View in: Pubmed

    • Targeting SDF-1 in multiple myeloma tumor microenvironment. Cancer Lett. 2016 09 28; 380(1):315-8. View in: Pubmed

    • Waldenström's macroglobulinemia: a clinical perspective in the era of novel therapeutics. Ann Oncol. 2016 Feb; 27(2):233-40. View in: Pubmed

    • Aberrant Levels of miRNAs in Bone Marrow Microenvironment and Peripheral Blood of Myeloma Patients and Disease Progression. J Mol Diagn. 2015 Nov; 17(6):669-78. View in: Pubmed

    • Drug-Related Pneumonitis During Mammalian Target of Rapamycin Inhibitor Therapy: Radiographic Pattern-Based Approach in Waldenström Macroglobulinemia as a Paradigm. Oncologist. 2015 Sep; 20(9):1077-83. View in: Pubmed

    • CXCR4 Regulates Extra-Medullary Myeloma through Epithelial-Mesenchymal-Transition-like Transcriptional Activation. Cell Rep. 2015 Jul 28; 12(4):622-35. View in: Pubmed

    • Phase I/II trial of everolimus in combination with bortezomib and rituximab (RVR) in relapsed/refractory Waldenstrom macroglobulinemia. Leukemia. 2015 Dec; 29(12):2338-46. View in: Pubmed

    • Development of extramedullary myeloma in the era of novel agents: no evidence of increased risk with lenalidomide-bortezomib combinations. Br J Haematol. 2015 Jun; 169(6):843-50. View in: Pubmed

    • Biological properties of extracellular vesicles and their physiological functions. J Extracell Vesicles. 2015; 4:27066. View in: Pubmed

    • Cyclophosphamide, bortezomib, and dexamethasone combination in waldenstrom macroglobulinemia. Am J Hematol. 2015 Jun; 90(6):E122-3. View in: Pubmed

    • The road to cure in multiple myeloma starts with smoldering disease. Expert Opin Orphan Drugs. 2015 Apr 12; 3(6). View in: Pubmed

    • Ibrutinib in previously treated Waldenström's macroglobulinemia. N Engl J Med. 2015 Apr 09; 372(15):1430-40. View in: Pubmed

    • Incidence and clinical features of extramedullary multiple myeloma in patients who underwent stem cell transplantation. Br J Haematol. 2015 Jun; 169(6):851-8. View in: Pubmed

    • American Society of Hematology Annual Meeting 2014: highlights in multiple myeloma. Expert Rev Hematol. 2015 Jun; 8(3):273-5. View in: Pubmed

    • Metabolic signature identifies novel targets for drug resistance in multiple myeloma. Cancer Res. 2015 May 15; 75(10):2071-82. View in: Pubmed

    • Dynamic interplay between bone and multiple myeloma: emerging roles of the osteoblast. Bone. 2015 Jun; 75:161-9. View in: Pubmed

    • The cancer glycome: carbohydrates as mediators of metastasis. Blood Rev. 2015 Jul; 29(4):269-79. View in: Pubmed

    • Biology, prognosis, and therapy of Waldenström Macroglobulinemia. Cancer Treat Res. 2015; 165:177-95. View in: Pubmed

    • Targeting the bone marrow microenvironment in multiple myeloma. Immunol Rev. 2015 Jan; 263(1):160-72. View in: Pubmed

    • Extramedullary Waldenström macroglobulinemia. Am J Hematol. 2015 Feb; 90(2):100-4. View in: Pubmed

    • Global epigenetic regulation of microRNAs in multiple myeloma. PLoS One. 2014; 9(10):e110973. View in: Pubmed

    • How I treat smoldering multiple myeloma. Blood. 2014 Nov 27; 124(23):3380-8. View in: Pubmed

    • Team work matters: dual inhibition puts non-hodgkin lymphoma under siege. Clin Cancer Res. 2014 Dec 01; 20(23):5863-5. View in: Pubmed

    • SDF-1 inhibition targets the bone marrow niche for cancer therapy. Cell Rep. 2014 Oct 09; 9(1):118-128. View in: Pubmed

    • Hypoxia promotes dissemination and colonization in new bone marrow niches in Waldenström macroglobulinemia. Mol Cancer Res. 2015 Feb; 13(2):263-72. View in: Pubmed

    • Pyk2 promotes tumor progression in multiple myeloma. Blood. 2014 Oct 23; 124(17):2675-86. View in: Pubmed

    • Investigating osteogenic differentiation in multiple myeloma using a novel 3D bone marrow niche model. Blood. 2014 Nov 20; 124(22):3250-9. View in: Pubmed

    • Targeting survival and cell trafficking in multiple myeloma and Waldenstrom macroglobulinemia using pan-class I PI3K inhibitor, buparlisib. Am J Hematol. 2014 Nov; 89(11):1030-6. View in: Pubmed

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    • Perifosine, an oral bioactive AKT inhibitor induces in vitro and in vivo antitumor activity in Waldenstrom Macroglobulinemia. XIth Internatinal Workshop on Multiple Myeloma & IVth International Workshop on Waldenstrom's Macroglobulinemia. 2007. View in: Pubmed

    • The combination of the mTOR inhibitor rapamycin and proteasome inhibitor Bortezomib is synergistic in vitro in Multiple Myeloma. XIth Internatinal Workshop on Multiple Myeloma & IVth International Workshop on Waldenstrom's Macroglobulinemia. 2007. View in: Pubmed

    • The treatment of relapsed and refractory multiple myeloma. Hematology Am Soc Hematol Educ Program. 2007; 317-23. View in: Pubmed

    • Targeting Akt and HSP90 produces synergistic Multiple Myeloma cell cytoxicity in the bone marrow microenvironment. Blood. 2007. View in: Pubmed

    • The CXCR4/SDF-1 axis regulates migration and adhesion in Waldenstrom macroglobulinemia. XIth Internatinal Workshop on Multiple Myeloma & IVth International Workshop on Waldenstrom's Macroglobulinemia. 2007. View in: Pubmed

    • Targeting the PI3K pathway in Multiple Myeloma. Clinical Cancer Research. 2007. View in: Pubmed

    • New frontiers in the treatment of multiple myeloma. ScientificWorldJournal. 2006 Dec 06; 6:1475-503. View in: Pubmed

    • Combination mammalian target of rapamycin inhibitor rapamycin and HSP90 inhibitor 17-allylamino-17-demethoxygeldanamycin has synergistic activity in multiple myeloma. Clin Cancer Res. 2006 Nov 15; 12(22):6826-35. View in: Pubmed

    • Beyond single-agent bortezomib: combination regimens in relapsed multiple myeloma. Curr Opin Oncol. 2006 Nov; 18(6):598-608. View in: Pubmed

    • A novel Bcl-2/Bcl-X(L)/Bcl-w inhibitor ABT-737 as therapy in multiple myeloma. Oncogene. 2007 Apr 05; 26(16):2374-80. View in: Pubmed

    • Chemokines in multiple myeloma. Exp Hematol. 2006 Oct; 34(10):1289-95. View in: Pubmed

    • The emerging role of novel therpeutic agents int he management of patients with multiple myeloma. Community Oncology. 2006; 3(9):575-582. View in: Pubmed

    • 6q deletion discriminates Waldenström macroglobulinemia from IgM monoclonal gammopathy of undetermined significance. Cancer Genet Cytogenet. 2006 Sep; 169(2):150-3. View in: Pubmed

    • Gene-expression profiling of Waldenstrom macroglobulinemia reveals a phenotype more similar to chronic lymphocytic leukemia than multiple myeloma. Blood. 2006 Oct 15; 108(8):2755-63. View in: Pubmed

    • Sildenafil citrate suppresses disease progression in patients with Waldenstrom's macroglobulinemia. J Clin Oncol. 2006 Jun 20; 24(18_suppl):7556. View in: Pubmed

    • Prognostic model for disease-specific and overall mortality in newly diagnosed symptomatic patients with Waldenstrom macroglobulinaemia. Br J Haematol. 2006 Apr; 133(2):158-64. View in: Pubmed

    • The PI3K/Akt pathway is an important regulator of homing and adhesion in Waldenstrom Macroglobulinemia. ASH. 2006. View in: Pubmed

    • A selection protein kinase C inhibitor Enzastaurin, induces in vitro and in vivo cytotoxicity in Waldenstrom Macroglobulinemia. ASH. 2006. View in: Pubmed

    • The Proteasome inhibitor NPI-0052 incombination with bortezomib induces antitumor activity in Waldenstrom Macroglobulinemia. ASH. 2006. View in: Pubmed

    • The CXCR4/SDF-1 axis regulates migration and adhesion in Waldenstrom Macroglobulinemia. ASH. 2006. View in: Pubmed

    • Novel Agent Perifosine enhances antitumor activity of Bortezomib and rituximab in Waldenstrom Macroglobulinemia. ASH. 2006. View in: Pubmed

    • A novel real-time in vivo homing model of multiple myeloma. ASH. 2006. View in: Pubmed

    • The combination of the mTOR inhibitor rapamycin and proteasome inhibitor Bortezomib in synergistic in vitro in Multiple Myeloma. ASH. 2006. View in: Pubmed

    • Perifosine, an oral bioactive AKT inhibitor induces in vitro and in vivo antitumor activity in Waldenstroms Macroglobulinemia. ASH. 2006. View in: Pubmed

    • Thalidomide derivative CC-4047 inhibits osteoclast formation by down-regulation of PU.1. Blood. 2006 Apr 15; 107(8):3098-105. View in: Pubmed

    • Prognostic analysis for survival in adult solid organ transplant recipients with post-transplantation lymphoproliferative disorders. J Clin Oncol. 2005 Oct 20; 23(30):7574-82. View in: Pubmed

    • Phase II trial of single-agent temsirolimus (CCI-779) for relapsed mantle cell lymphoma. J Clin Oncol. 2005 Aug 10; 23(23):5347-56. View in: Pubmed

    • IL-3 is a potential inhibitor of osteoblast differentiation in multiple myeloma. Blood. 2005 Aug 15; 106(4):1407-14. View in: Pubmed

    • Clinical outcome of patients with subcutaneous panniculitis-like T-cell lymphoma. Leuk Lymphoma. 2005 May; 46(5):703-8. View in: Pubmed

    • Targeting apoptosis pathways in cancer therapy. CA Cancer J Clin. 2005 May-Jun; 55(3):178-94. View in: Pubmed

    • Experimental design and analysis of antibody microarrays: applying methods from cDNA arrays. Cancer Res. 2005 Apr 15; 65(8):2985-9. View in: Pubmed

    • Prognostic factors in patients with post-transplant lymphoproliferative disorders (PTLD) in the rituximab era. Leuk Lymphoma. 2005 Feb; 46(2):191-6. View in: Pubmed

    • Differences between early and late posttransplant lymphoproliferative disorders in solid organ transplant patients: are they two different diseases? Transplantation. 2005 Jan 27; 79(2):244-7. View in: Pubmed

    • Proteomic analysis of mantle-cell lymphoma by protein microarray. Blood. 2005 May 01; 105(9):3722-30. View in: Pubmed

    • Role of the CXCR4 inhibitor AMD3100 in mulitple myeloma (MM). ASH. 2005. View in: Pubmed

    • Zoledronic acid inhibits CXCR-4-mediated prostate cancer cell invasion through an NFÉ»B independent pathway in vitro. AACR. 2005. View in: Pubmed

    • Proteomic Analysis of Multiple Myeloma Identifies Potential Targets for Drug Therapy. 10Th International Myeloma Workshop. 2005. View in: Pubmed

    • Molecular Mechanisms Involved in Homing and Migration of Plasma Cells in Response to CXCR4 Stimulation and Downstream Activation of The PI3K Pathway. 10Th International Myeloma Workshop. 2005. View in: Pubmed

    • The effect of rapamycin, 17-AAG and the combination on the bone marrow microenvironment in Multiple Myeloma (MM). ASH. 2005. View in: Pubmed

    • Proteomic analysis identifies differences in multiple myeloma (MM) cells sensitive and resistant to AKT inhibition. ASH. 2005. View in: Pubmed

    • The Role of CXCR4 inhibitors as Novel Antiangiogenesis Agents in Cancer Therapy. 10th Annyal Internation Myeloma Workshop. 2005. View in: Pubmed

    • Differential response to proteosome inhibition in EBV positive and negative lymphoma cell lines: clinical implications in post transplant lymphoproliferative disorders (PtLD). 2005. View in: Pubmed

    • Proteomic Analysis of Multiple Myeloma Identifies Potential Targets for Drug Therapy. 10th Annual Myeloma Workshop. 2005. View in: Pubmed

    • Role of cathepsin K in prostate cancer skeletal metastasis. AACR. 2005. View in: Pubmed

    • Combination of the AKT inhibitor perifosine with the HSP90 inhibitor 17-(dimethylaminoethyulamino)-17-demethoxygeldanamycin (17-DMAG) has synergistic activity in Multiple Myeloma (MM). ASH. 2005. View in: Pubmed

    • Zoledronic acid inhibits CXCR-4 mediated prostate cancer cell invasion through an NFE>>B independent pathway in vitro. AACR. 2005. View in: Pubmed

    • Combination of the mTOR inhibitor rapamycin with the HSP90 inhibitor 17-AAG has synergistic activity in EBV positive and negative post transplant lymphoproliferative disorders (PTLD). ASH. 2005. View in: Pubmed

    • Proteomic analysis of Waldenstrom Macroglobulinemia (WM) using nanoscale protein microarray techniques. ASH. 2005. View in: Pubmed

    • Role of cathepsin K in prostate cancer skeletal meastasis. AACR. 2005. View in: Pubmed

    • The Role of CXCR4 Inhibitors as Novel Antiangiogenesis Agents in Cancer Therapy. 10Th International Myeloma Workshop. 2005. View in: Pubmed

    • The role of the AKT inhibitor perifosine in migration and adhesion in multiple myeloma (MM). ASH. 2005. View in: Pubmed

    • Proteomic Analysis of Targeted Therapeutic Agents in Multiple Myeloma (MM). 10th International Myeloma Workshop. 2005. View in: Pubmed

    • Role of the chemokine receptor CXCR4 in Waldenstrom Macroglobulinemia. ASH. 2005. View in: Pubmed

    • Molecular mechanisms regulating migration and adhesion in response to the chemokine SDF-1 in multiple myeloma (MM). ASH. 2005. View in: Pubmed

    • Combination of the mTOR inhibitor Rapamycin and HSP90 inhibitor 17AAG in Multiple Myeloma. ASCO. 2005. View in: Pubmed

    • Proteomic analysis of post transplant lymphoproliferative disorders (PTLD) using nanoscale protein microarray techniques. ASH. 2005. View in: Pubmed

    • Initial immunoglobulin M 'flare' after rituximab therapy in patients diagnosed with Waldenstrom macroglobulinemia: an Eastern Cooperative Oncology Group Study. Cancer. 2004 Dec 01; 101(11):2593-8. View in: Pubmed

    • Initial increase in the cryoglobulin level after rituximab therapy for type II cryoglobulinemia secondary to Waldenström macroglobulinemia does not indicate failure of response. Am J Hematol. 2004 Dec; 77(4):329-30. View in: Pubmed

    • Proteomic analysis of patients with mantle cell lymphoma identifies Hsp90, and other proteins as potential target(s) for drug therapy. J Clin Oncol. 2004 Jul 15; 22(14_suppl):6530. View in: Pubmed

    • Waldenström macroglobulinemia. Curr Treat Options Oncol. 2004 Jun; 5(3):239-47. View in: Pubmed

    • High-dose intravenous methotrexate followed by autologous stem cell transplantation as a potentially effective therapy for neurolymphomatosis. Cancer. 2004 Jun 01; 100(11):2403-7. View in: Pubmed

    • Radioimmunotherapy: a new treatment modality for B-cell non-Hodgkin's lymphoma. Oncology (Williston Park). 2004 May; 18(5):623-30; discussion 633-4, 637-8, 640. View in: Pubmed

    • Expression of the chemokine receptors CXCR4 and CCR7 and disease progression in B-cell chronic lymphocytic leukemia/ small lymphocytic lymphoma. Mayo Clin Proc. 2004 Mar; 79(3):318-25. View in: Pubmed

    • Fatal coronary artery disease after unrelated donor bone marrow transplantation. Mayo Clin Proc. 2004 Mar; 79(3):403-6. View in: Pubmed

    • Therapeutic options in patients with lymphoma and severe liver dysfunction. Mayo Clin Proc. 2004 Feb; 79(2):169-75. View in: Pubmed

    • Anti-Tumor Activity of Single-Agent CCI-779 for Relapsed Mantle Cell Lymphoma: A Phase II Trial in the North Central Cancer Treatment Group. ASH . 2004. View in: Pubmed

    • Molecular Mechanisms Involved in Homing and Migration of B-Chronic Lymphocytic Leukemia (CLL) in Response to CXCR4 Stimulation and Downstream Activation of the PI3K Pathway. ASH. 2004. View in: Pubmed

    • Proteomic Analysis of Waldenstrom Macroglobulinemia (WM) and IgM Monoclonal Gammopathy of Undetermined Significance (IgM-MGUS) Identifies Potential Targets for Drug Therapy. ASH. 2004. View in: Pubmed

    • The Role of CXCR4 Inhibitors as Novel Antiangiogenesis Agents in Cancer Therapy. ASH. 2004. View in: Pubmed

    • Experimental Design & Analysis of Protein Array Data: Applying Methods from cDNA Arrays. ASH. 2004. View in: Pubmed

    • Expression of the chemokine receptors CXCR4 and CCR7 and disease progression in B-cell chronic lymphocytic leukemia/ small lymphocytic lymphoma. National Institute of Health. 2004. View in: Pubmed

    • Proteomic analysis of mantle cell lymphoma. National Institute of Health. 2004. View in: Pubmed

    • Proteomic analysis of patients with mantle cell lymphoma identifies Hsp90 and other proteins as potential target(s) for drug therapy. ASCO. 2004. View in: Pubmed

    • Proteomic Analysis of Multiple Myeloma Identifies Potential Targets for Drug Therapy . ASH. 2004. View in: Pubmed

    • Proteomic Analysis of Targeted Therapeutic Agents in Multiple Myeloma (MM). ASH. 2004. View in: Pubmed

    • Molecular Mechanisms Involved in Homing and Migration of Plasma Cells in Response to CXCR4 Stimulation and Downstream Activation of The PI3K Pathway. ASH. 2004. View in: Pubmed

    • Characterization of Waldenström Macroglobulinemia Subtypes Using Global Gene Expression Profiling. ASH. 2004. View in: Pubmed

    • CCI-779 inhibits phosphorylation of ribosomal S6 (pS6) in mantle cell lymphoma. AACR. 2004. View in: Pubmed

    • Renal cell carcinoma with acrometastasis and scalp metastasis. Mayo Clin Proc. 2004 Jan; 79(1):76. View in: Pubmed

    • An EBV-positive lymphoproliferative disorder after therapy with alemtuzumab. N Engl J Med. 2003 Dec 25; 349(26):2570-2; discussion 2570-2. View in: Pubmed

    • Waldenström macroglobulinaemia. Lancet Oncol. 2003 Nov; 4(11):679-85. View in: Pubmed

    • Management of thalidomide toxicity. J Support Oncol. 2003 Sep-Oct; 1(3):194-205. View in: Pubmed

    • Effect of thalidomide on stem cell collection and engraftment in patients with multiple myeloma. Bone Marrow Transplant. 2003 Sep; 32(6):587-92. View in: Pubmed

    • Rituximab and IPI are prognostic indicators in post transplant lymphoproliferative disorders (PTLD). American Society of Clinical Oncology. 2003. View in: Pubmed

    • Prognostic model for patients with Post Transplant Lymphoproliferative Disorders. Blood. 2003. View in: Pubmed

    • The IgM flare in patients diagnosed with Waldenstrom Macroglobulinemia and treated with rituximab: an ECOG study. Blood. 2003. View in: Pubmed

    • CNS Post Transplant Lymphoproliferative Disorders: therapy with rituximab. Blood. 2003. View in: Pubmed

    • Expression of the chemokine receptors CXCR4 and CCR7 and disease progression in B-cell chronic lymphocytic leukemia/small lymphocytic lymphoma. Panpacific Lymphoma Conference. 2003. View in: Pubmed

    • Differences between early and late Post Transplant Lymphoproliferative Disorders: are they two different diseases. Blood. 2003. View in: Pubmed

    • Prognostic model for 506 patients diagnosed with Waldenstrom Macroglobulinemia,. Blood. 2003. View in: Pubmed

    • Therapeutic options in patients with lymphoma and severe liver dysfunction. Blood. 2003. View in: Pubmed

    • Deletions of 6q predominantly involve band q23 and distinguish Waldenström macroglobulinemia from IgM monoclonal gammopathy of undetermined significance. Blood. 2003. View in: Pubmed

    • Subcutaneous Panniculitis-like T cell lymphoma: clinical presentation and follow up of 17 patients. Blood. 2003. View in: Pubmed

    • Inhibitors of the ras oncogene as therapeutic targets. Hematol Oncol Clin North Am. 2002 Oct; 16(5):1065-88. View in: Pubmed

    • T-cell activation and lymphokine production induced by antihuman CD3 monoclonal antibodies. Transplant Proc. 1991 Feb; 23(1 Pt 1):81-2. View in: Pubmed

    • The mechanism of anti-CD3 monoclonal antibodies. Mediation of cytolysis by inter-T cell bridging. Transplantation. 1990 Oct; 50(4):683-9. View in: Pubmed

    • T cells in patients undergoing chronic hemodialysis: mitogenic response, suppressor activity, and interleukin-2 production and receptor generation. Diagn Immunol. 1986; 4(4):209-16. View in: Pubmed

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