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James A. DeCaprio, MD


Medical Oncology

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Physician

  • Physician
  • Professor of Medicine, Harvard Medical School

Centers/Programs

Clinical Interests

  • Viral oncology

Contact Information

  • Appointments617-632-6140
  • Office Phone Number617-632-3825
  • Fax617-582-8601

Bio

Dr. DeCaprio received his MD in 1984 from the University at Buffalo School of Medicine and Biomedical Sciences. He completed his internal medicine residency at the University of Chicago, and his medical oncology fellowship at DFCI. In 1992, he joined the faculty of DFCI, where his laboratory has focused on mechanisms of cellular transformation and oncogenesis.

Fellowship:

  • Dana-Farber Cancer Institute, Medical Oncology

Residency:

  • University of Chicago, Internal Medicine

Medical School:

  • University at Buffalo School of Medicine and Biomedical Sciences

Recent Awards:

  • American Society for Clinical Investigation 1997
  • Scholar, Leukemia Society of America 1997
  • Stohlman Scholar, Leukemia & Lymphoma Society 2002
  • Biological and Biochemical Sciences HMS Award in Teaching 2000
  • Association of American Physicians 2004
  • Harvard University GSAS Everett Mendelsohn Excellence in Mentoring Award 2004

Research

Mechanisms of Cellular Transformation and Oncogenesis

Viral oncology

Our laboratory examines how viruses can cause human cancer. In particular, we study the family of small DNA tumor viruses that include human papilloma virus (HPV) and polyomavirus. HPV can cause cervical cancer and oropharyngeal cancer. The Merkel cell polyomavirus can cause Merkel cell carcinoma, a highly lethal form of skin cancer.  Our laboratory studies how these viruses infect normal human cells and the consequences of the subsequent interactions between the viral oncogenes and the cellular DNA, genes and proteins.

Cell Cycle

One hallmark of cancer is rapid and uncontrolled proliferation. A cancer cell retains the ability to replicate its DNA and undergo cell division similar to a normal cell. However, a cancer cell has lost important checkpoints that regulate entry into the cell cycle, resulting in continuous and inappropriate cell proliferation. Our laboratory has focused on transcription factors that regulate entry into and progression through the cell cycle. In addition, we study how a cell and a tumor can stop proliferating by exiting the cell cycle and entering into a state of cellular quiescence or senescence and tumor dormancy.

An analysis of the use of targeted therapies in patients with advanced Merkel cell carcinoma and an evaluation of genomic correlates of response. Cancer Med. 2021 Jul 16.
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MMB-FOXM1-driven premature mitosis is required for CHK1 inhibitor sensitivity. Cell Rep. 2021 Mar 02; 34(9):108808.
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The Merkel Cell Polyomavirus T Antigens Function as Tumor Promoters in Murine Skin. Cancers (Basel). 2021 Jan 09; 13(2).
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Pervasive generation of non-canonical subgenomic RNAs by SARS-CoV-2. Genome Med. 2020 12 01; 12(1):108.
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Predictors of immunotherapy benefit in Merkel cell carcinoma. Oncotarget. 2020 Nov 24; 11(47):4401-4410.
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Molecular Pathogenesis of Merkel Cell Carcinoma. Annu Rev Pathol. 2021 01 24; 16:69-91.
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Association between treatment center experience and survival after diagnosis of stage I to III Merkel cell carcinoma treated with surgery with or without postoperative radiation therapy. J Am Acad Dermatol. 2021 Mar; 84(3):875-877.
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CHK1 Inhibitor Blocks Phosphorylation of FAM122A and Promotes Replication Stress. Mol Cell. 2020 11 05; 80(3):410-422.e6.
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Real-world outcomes treating patients with advanced cutaneous squamous cell carcinoma with immune checkpoint inhibitors (CPI). Br J Cancer. 2020 11; 123(10):1535-1542.
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Association of Programmed Death 1 Protein Ligand (PD-L1) Expression With Prognosis in Merkel Cell Carcinoma. Front Med (Lausanne). 2020; 7:198.
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Author Correction: Merkel cell polyomavirus activates LSD1-mediated blockade of non-canonical BAF to regulate transformation and tumorigenesis. Nat Cell Biol. 2020 06; 22(6):752.
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Merkel cell polyomavirus activates LSD1-mediated blockade of non-canonical BAF to regulate transformation and tumorigenesis. Nat Cell Biol. 2020 05; 22(5):603-615.
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Comprehensive metagenomic analysis of blastic plasmacytoid dendritic cell neoplasm. Blood Adv. 2020 03 24; 4(6):1006-1011.
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Clinical and molecular characterization of virus-positive and virus-negative Merkel cell carcinoma. Genome Med. 2020 03 18; 12(1):30.
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ViroPanel: Hybrid Capture and Massively Parallel Sequencing for Simultaneous Detection and Profiling of Oncogenic Virus Infection and Tumor Genome. J Mol Diagn. 2020 04; 22(4):476-487.
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Denaturing Lysis of Cells for Immunoprecipitation. Cold Spring Harb Protoc. 2020 02 03; 2020(2):098616.
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STRIPAK directs PP2A activity toward MAP4K4 to promote oncogenic transformation of human cells. Elife. 2020 Jan 08; 9.
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Preparing Protein Antigens from Sodium Dodecyl Sulfate-Polyacrylamide Gels for Immunization. Cold Spring Harb Protoc. 2019 12 02; 2019(12).
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RB, p130 and p107 differentially repress G1/S and G2/M genes after p53 activation. Nucleic Acids Res. 2019 12 02; 47(21):11197-11208.
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The Genomic Landscape of Merkel Cell Carcinoma and Clinicogenomic Biomarkers of Response to Immune Checkpoint Inhibitor Therapy. Clin Cancer Res. 2019 10 01; 25(19):5961-5971.
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Cyclin D-CDK4 relieves cooperative repression of proliferation and cell cycle gene expression by DREAM and RB. Oncogene. 2019 06; 38(25):4962-4976.
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Transfected Dendritic Cell Immunizations. Cold Spring Harb Protoc. 2019 03 01; 2019(3).
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DYRK1A regulates the recruitment of 53BP1 to the sites of DNA damage in part through interaction with RNF169. . 2019 03; 18(5):531-551.
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A Murine Model of Chronic Lymphocytic Leukemia Based on B Cell-Restricted Expression of Sf3b1 Mutation and Atm Deletion. Cancer Cell. 2019 02 11; 35(2):283-296.e5.
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Merkel Cell Carcinoma in the HIV-1/AIDS Patient. Cancer Treat Res. 2019; 177:211-229.
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Dual inhibition of MDM2 and MDM4 in virus-positive Merkel cell carcinoma enhances the p53 response. Proc Natl Acad Sci U S A. 2019 01 15; 116(3):1027-1032.
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SPOP Promotes Nanog Destruction to Suppress Stem Cell Traits and Prostate Cancer Progression. Dev Cell. 2019 02 11; 48(3):329-344.e5.
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Contribution of DNA Replication to the FAM111A-Mediated Simian Virus 40 Host Range Phenotype. J Virol. 2019 01 01; 93(1).
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The biology and treatment of Merkel cell carcinoma: current understanding and research priorities. Nat Rev Clin Oncol. 2018 12; 15(12):763-776.
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Metabolic Labeling of Protein Antigens with [32P]Orthophosphate. Cold Spring Harb Protoc. 2018 09 04; 2018(9).
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Cabozantinib in Patients with Advanced Merkel Cell Carcinoma. Oncologist. 2018 07; 23(7):814-821.
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Epidemiology, biology and therapy of Merkel cell carcinoma: conclusions from the EU project IMMOMEC. Cancer Immunol Immunother. 2018 03; 67(3):341-351.
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Merkel cell carcinoma. Nat Rev Dis Primers. 2017 Oct 26; 3:17077.
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Merkel cell polyomavirus and Merkel cell carcinoma. Philos Trans R Soc Lond B Biol Sci. 2017 Oct 19; 372(1732).
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Merkel cell polyomavirus recruits MYCL to the EP400 complex to promote oncogenesis. PLoS Pathog. 2017 Oct; 13(10):e1006668.
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Transcriptional landscape of the human cell cycle. Proc Natl Acad Sci U S A. 2017 03 28; 114(13):3473-3478.
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Merkel Cell Polyomavirus Exhibits Dominant Control of the Tumor Genome and Transcriptome in Virus-Associated Merkel Cell Carcinoma. mBio. 2017 01 03; 8(1).
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Merkel Cell Polyomavirus Small T Antigen Promotes Pro-Glycolytic Metabolic Perturbations Required for Transformation. PLoS Pathog. 2016 Nov; 12(11):e1006020.
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Proteomic Landscape of Tissue-Specific Cyclin E Functions in Vivo. PLoS Genet. 2016 Nov; 12(11):e1006429.
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Merkel Cell Carcinoma: A Population Analysis on Survival. J Natl Compr Canc Netw. 2016 10; 14(10):1247-1257.
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APC/C and SCF(cyclin F) Constitute a Reciprocal Feedback Circuit Controlling S-Phase Entry. Cell Rep. 2016 09 20; 16(12):3359-3372.
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Integration of TP53, DREAM, MMB-FOXM1 and RB-E2F target gene analyses identifies cell cycle gene regulatory networks. Nucleic Acids Res. 2016 Jul 27; 44(13):6070-86.
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Inhibition of Rb Phosphorylation Leads to mTORC2-Mediated Activation of Akt. Mol Cell. 2016 06 16; 62(6):929-942.
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Does Arabidopsis thaliana DREAM of cell cycle control? EMBO J. 2015 Aug 04; 34(15):1987-9.
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Tumorigenic activity of merkel cell polyomavirus T antigens expressed in the stratified epithelium of mice. Cancer Res. 2015 Mar 15; 75(6):1068-79.
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Malawi polyomavirus is a prevalent human virus that interacts with known tumor suppressors. J Virol. 2015 Jan; 89(1):857-62.
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SMCX and components of the TIP60 complex contribute to E2 regulation of the HPV E6/E7 promoter. Virology. 2014 Nov; 468-470:311-321.
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The DREAM complex in antitumor activity of imatinib mesylate in gastrointestinal stromal tumors. Curr Opin Oncol. 2014 Jul; 26(4):415-21.
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PP2A-mediated regulation of Ras signaling in G2 is essential for stable quiescence and normal G1 length. Mol Cell. 2014 Jun 19; 54(6):932-45.
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Loss of the mammalian DREAM complex deregulates chondrocyte proliferation. Mol Cell Biol. 2014 Jun; 34(12):2221-34.
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Nuclear interferon-inducible protein 16 promotes silencing of herpesviral and transfected DNA. Proc Natl Acad Sci U S A. 2013 Nov 19; 110(47):E4492-501.
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Human papillomavirus type 16 E7 perturbs DREAM to promote cellular proliferation and mitotic gene expression. Oncogene. 2014 Jul 31; 33(31):4036-8.
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The DNA damage and the DNA replication checkpoints converge at the MBF transcription factor. Mol Biol Cell. 2013 Nov; 24(21):3350-7.
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The DREAM complex: master coordinator of cell cycle-dependent gene expression. Nat Rev Cancer. 2013 08; 13(8):585-95.
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The DREAM complex mediates GIST cell quiescence and is a novel therapeutic target to enhance imatinib-induced apoptosis. Cancer Res. 2013 Aug 15; 73(16):5120-9.
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Merkel cell polyomavirus large T antigen has growth-promoting and inhibitory activities. J Virol. 2013 Jun; 87(11):6118-26.
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A cornucopia of human polyomaviruses. Nat Rev Microbiol. 2013 Apr; 11(4):264-76.
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Improved detection suggests all Merkel cell carcinomas harbor Merkel polyomavirus. J Clin Invest. 2012 Dec; 122(12):4645-53.
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Identification of FAM111A as an SV40 host range restriction and adenovirus helper factor. PLoS Pathog. 2012; 8(10):e1002949.
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Interpreting cancer genomes using systematic host network perturbations by tumour virus proteins. Nature. 2012 Jul 26; 487(7408):491-5.
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Viral perturbations of host networks reflect disease etiology. PLoS Comput Biol. 2012; 8(6):e1002531.
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Structure of a glomulin-RBX1-CUL1 complex: inhibition of a RING E3 ligase through masking of its E2-binding surface. Mol Cell. 2012 Aug 10; 47(3):371-82.
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Negative regulation of the stability and tumor suppressor function of Fbw7 by the Pin1 prolyl isomerase. Mol Cell. 2012 Jun 29; 46(6):771-83.
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The glomuvenous malformation protein Glomulin binds Rbx1 and regulates cullin RING ligase-mediated turnover of Fbw7. Mol Cell. 2012 Apr 13; 46(1):67-78.
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The MuvB complex sequentially recruits B-Myb and FoxM1 to promote mitotic gene expression. Genes Dev. 2012 Mar 01; 26(5):474-89.
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The CHR promoter element controls cell cycle-dependent gene transcription and binds the DREAM and MMB complexes. Nucleic Acids Res. 2012 Feb; 40(4):1561-78.
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DYRK1A protein kinase promotes quiescence and senescence through DREAM complex assembly. Genes Dev. 2011 Apr 15; 25(8):801-13.
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A kinase shRNA screen links LATS2 and the pRB tumor suppressor. Genes Dev. 2011 Apr 15; 25(8):814-30.
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Rictor forms a complex with Cullin-1 to promote SGK1 ubiquitination and destruction. Mol Cell. 2010 Sep 10; 39(5):797-808.
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Does detection of Merkel cell polyomavirus in Merkel cell carcinoma provide prognostic information? J Natl Cancer Inst. 2009 Jul 01; 101(13):905-7.
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A compendium of potential biomarkers of pancreatic cancer. PLoS Med. 2009 Apr 07; 6(4):e1000046.
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Cellular transformation by Simian Virus 40 and Murine Polyoma Virus T antigens. Semin Cancer Biol. 2009 Aug; 19(4):218-28.
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How the Rb tumor suppressor structure and function was revealed by the study of Adenovirus and SV40. Virology. 2009 Feb 20; 384(2):274-84.
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Plakophilin3 downregulation leads to a decrease in cell adhesion and promotes metastasis. Int J Cancer. 2008 Nov 15; 123(10):2303-14.
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Does a new polyomavirus contribute to Merkel cell carcinoma? Genome Biol. 2008; 9(6):228.
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AMP-activated protein kinase is essential for survival in chronic hypoxia. Biochem Biophys Res Commun. 2008 May 30; 370(2):230-4.
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Disruption of the Fbxw8 gene results in pre- and postnatal growth retardation in mice. Mol Cell Biol. 2008 Jan; 28(2):743-51.
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The tumor suppressor PP2A Abeta regulates the RalA GTPase. Cell. 2007 Jun 01; 129(5):969-82.
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Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence. Mol Cell. 2007 May 25; 26(4):539-51.
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PARC and CUL7 form atypical cullin RING ligase complexes. Cancer Res. 2007 Mar 01; 67(5):2006-14.
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Inhibition of Simian virus 40 large T antigen helicase activity by fluoroquinolones. Antivir Ther. 2007; 12(1):1-6.
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Is there a role for SV40 in human cancer? J Clin Oncol. 2006 Sep 10; 24(26):4356-65.
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A novel p53-binding domain in CUL7. Biochem Biophys Res Commun. 2006 Sep 15; 348(1):132-8.
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Targeting of p300/CREB binding protein coactivators by simian virus 40 is mediated through p53. J Virol. 2006 May; 80(9):4292-303.
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The carboxyl-terminal domain of large T antigen rescues SV40 host range activity in trans independent of acetylation. Virology. 2006 May 25; 349(1):212-21.
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Simian virus 40 large T antigen's association with the CUL7 SCF complex contributes to cellular transformation. J Virol. 2005 Sep; 79(18):11685-92.
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Dimerization of CUL7 and PARC is not required for all CUL7 functions and mouse development. Mol Cell Biol. 2005 Jul; 25(13):5579-89.
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Glycogen synthase kinase 3 phosphorylates RBL2/p130 during quiescence. Mol Cell Biol. 2004 Oct; 24(20):8970-80.
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p53 targets simian virus 40 large T antigen for acetylation by CBP. J Virol. 2004 Aug; 78(15):8245-53.
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Activation of a DNA damage checkpoint response in a TAF1-defective cell line. Mol Cell Biol. 2004 Jun; 24(12):5332-9.
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14-3-3 family members act coordinately to regulate mitotic progression. . 2004 May; 3(5):672-7.
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Cul7/p185/p193 binding to simian virus 40 large T antigen has a role in cellular transformation. J Virol. 2004 Mar; 78(6):2749-57.
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Molecular cloning and characterization of the von Hippel-Lindau-like protein. Mol Cancer Res. 2004 Jan; 2(1):43-52.
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Proteomics-based target identification: bengamides as a new class of methionine aminopeptidase inhibitors. J Biol Chem. 2003 Dec 26; 278(52):52964-71.
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SV40 large T antigen promotes dephosphorylation of p130. J Biol Chem. 2003 Nov 21; 278(47):46482-7.
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Targeted disruption of p185/Cul7 gene results in abnormal vascular morphogenesis. Proc Natl Acad Sci U S A. 2003 Aug 19; 100(17):9855-60.
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Telomerase maintains telomere structure in normal human cells. Cell. 2003 Jul 25; 114(2):241-53.
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Fludarabine-induced apoptosis of B chronic lymphocytic leukemia cells includes early cleavage of p27kip1 by caspases. Leukemia. 2003 Jun; 17(6):1104-11.
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Structure of the replicative helicase of the oncoprotein SV40 large tumour antigen. Nature. 2003 May 29; 423(6939):512-8.
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Processing, localization, and requirement of human separase for normal anaphase progression. Proc Natl Acad Sci U S A. 2003 Apr 15; 100(8):4574-9.
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Western blot screening for monoclonal antibodies against human separase. J Immunol Methods. 2003 Mar 01; 274(1-2):105-13.
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NFATc2-mediated repression of cyclin-dependent kinase 4 expression. Mol Cell. 2002 Nov; 10(5):1071-81.
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Enumeration of the simian virus 40 early region elements necessary for human cell transformation. Mol Cell Biol. 2002 Apr; 22(7):2111-23.
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14-3-3 transits to the nucleus and participates in dynamic nucleocytoplasmic transport. J Cell Biol. 2002 Mar 04; 156(5):817-28.
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Nucleocytoplasmic shuttling of p130/RBL2: novel regulatory mechanism. Mol Cell Biol. 2002 Jan; 22(2):453-68.
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Feedback regulation of the MBF transcription factor by cyclin Cig2. Nat Cell Biol. 2001 Dec; 3(12):1043-50.
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HIRA, the human homologue of yeast Hir1p and Hir2p, is a novel cyclin-cdk2 substrate whose expression blocks S-phase progression. Mol Cell Biol. 2001 Mar; 21(5):1854-65.
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Cellular transformation by SV40 large T antigen: interaction with host proteins. Semin Cancer Biol. 2001 Feb; 11(1):15-23.
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Binding of SV40 large T antigen to the retinoblastoma susceptibility gene product and related proteins. Methods Mol Biol. 2001; 165:213-8.
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Cells degrade a novel inhibitor of differentiation with E1A-like properties upon exiting the cell cycle. Mol Cell Biol. 2000 Dec; 20(23):8889-902.
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Phosphorylation of the retinoblastoma-related protein p130 in growth-arrested cells. Oncogene. 2000 Oct 19; 19(44):5116-22.
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Loss of p19(ARF) eliminates the requirement for the pRB-binding motif in simian virus 40 large T antigen-mediated transformation. Mol Cell Biol. 2000 Oct; 20(20):7624-33.
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Bcl-2 retards cell cycle entry through p27(Kip1), pRB relative p130, and altered E2F regulation. Mol Cell Biol. 2000 Jul; 20(13):4745-53.
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Calcineurin regulation of the mammalian G0/G1 checkpoint element, cyclin dependent kinase 4. Oncogene. 2000 Jun 01; 19(24):2820-7.
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pRB-dependent, J domain-independent function of simian virus 40 large T antigen in override of p53 growth suppression. J Virol. 2000 Jan; 74(2):864-74.
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RBP1 recruits both histone deacetylase-dependent and -independent repression activities to retinoblastoma family proteins. Mol Cell Biol. 1999 Oct; 19(10):6632-41.
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Discrimination between sialic acid-containing receptors and pseudoreceptors regulates polyomavirus spread in the mouse. J Virol. 1999 Jul; 73(7):5826-32.
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Cytoplasmic localization of human cdc25C during interphase requires an intact 14-3-3 binding site. Mol Cell Biol. 1999 Jun; 19(6):4465-79.
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Functional interaction between retinoblastoma protein and stress-activated protein kinase in multiple myeloma cells. Cancer Res. 1999 Mar 15; 59(6):1192-5.
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The role of the J domain of SV40 large T in cellular transformation. Biologicals. 1999 Mar; 27(1):23-8.
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Segregation of steroid receptor coactivator-1 from steroid receptors in mammary epithelium. Proc Natl Acad Sci U S A. 1999 Jan 05; 96(1):208-13.
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Viral oncoproteins discriminate between p53 and the p53 homolog p73. Mol Cell Biol. 1998 Nov; 18(11):6316-24.
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Inhibition of cellular proliferation by the Wilms tumor suppressor WT1 requires association with the inducible chaperone Hsp70. Genes Dev. 1998 Apr 15; 12(8):1108-20.
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The J domain of simian virus 40 large T antigen is required to functionally inactivate RB family proteins. Mol Cell Biol. 1998 Mar; 18(3):1408-15.
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SV40 as an oncogenic virus and possible human pathogen. Dev Biol Stand. 1998; 94:355-60, 369-82.
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The DnaJ domain of polyomavirus large T antigen is required to regulate Rb family tumor suppressor function. J Virol. 1997 Dec; 71(12):9410-6.
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p16INK4A promotes differentiation and inhibits apoptosis of JKB acute lymphoblastic leukemia cells. Blood. 1997 Nov 15; 90(10):4106-15.
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Characterization of p16(INK4A) expression in multiple myeloma and plasma cell leukemia. Clin Cancer Res. 1997 Nov; 3(11):2173-9.
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The fission yeast protein p73res2 is an essential component of the mitotic MBF complex and a master regulator of meiosis. Mol Cell Biol. 1997 Nov; 17(11):6246-54.
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Role of CDK4 and p16INK4A in interleukin-6-mediated growth of multiple myeloma. Leukemia. 1997 Nov; 11(11):1957-63.
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Inactivation of pRB-related proteins p130 and p107 mediated by the J domain of simian virus 40 large T antigen. Mol Cell Biol. 1997 Sep; 17(9):4979-90.
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MDM2 protein overexpression promotes proliferation and survival of multiple myeloma cells. Blood. 1997 Sep 01; 90(5):1982-92.
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Binding and modulation of p53 by p300/CBP coactivators. Nature. 1997 Jun 19; 387(6635):823-7.
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Mitogenic stimulation of resting T cells causes rapid phosphorylation of the transcription factor LSF and increased DNA-binding activity. Genes Dev. 1997 Jun 01; 11(11):1435-46.
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DnaJ/hsp40 chaperone domain of SV40 large T antigen promotes efficient viral DNA replication. Genes Dev. 1997 May 01; 11(9):1098-110.
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Ras signalling linked to the cell-cycle machinery by the retinoblastoma protein. Nature. 1997 Mar 13; 386(6621):177-81.
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Cyclin E, a redundant cyclin in breast cancer. Proc Natl Acad Sci U S A. 1996 Dec 24; 93(26):15215-20.
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A novel pre-B acute lymphoblastic leukemia cell line with chromosomal translocation between p16(INK4A)/p15(INK4B) tumor suppressor and immunoglobulin heavy chain genes: TGFbeta/IL-7 inhibitory signaling mechanism. Leukemia. 1996 Oct; 10(10):1576-83.
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Interleukin-6 promotes multiple myeloma cell growth via phosphorylation of retinoblastoma protein. Blood. 1996 Sep 15; 88(6):2219-27.
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A maize cDNA encoding a member of the retinoblastoma protein family: involvement in endoreduplication. Proc Natl Acad Sci U S A. 1996 Aug 20; 93(17):8962-7.
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Association of p300 and CBP with simian virus 40 large T antigen. Mol Cell Biol. 1996 Jul; 16(7):3454-64.
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Simian virus 40 large T antigen alters the phosphorylation state of the RB-related proteins p130 and p107. J Virol. 1996 May; 70(5):2781-8.
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Role of pRb-related proteins in simian virus 40 large-T-antigen-mediated transformation. Mol Cell Biol. 1995 Oct; 15(10):5800-10.
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Binding of the von Hippel-Lindau tumor suppressor protein to Elongin B and C. Science. 1995 Sep 08; 269(5229):1444-6.
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The Schizosaccharomyces pombe MBF complex requires heterodimerization for entry into S phase. Mol Cell Biol. 1995 May; 15(5):2589-99.
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Cell synchronization. Methods Enzymol. 1995; 254:114-24.
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E2F-4, a new member of the E2F transcription factor family, interacts with p107. Genes Dev. 1994 Nov 15; 8(22):2665-79.
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Molecular cloning and functional analysis of the adenovirus E1A-associated 300-kD protein (p300) reveals a protein with properties of a transcriptional adaptor. Genes Dev. 1994 Apr 15; 8(8):869-84.
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Cell cycle analysis of E2F in primary human T cells reveals novel E2F complexes and biochemically distinct forms of free E2F. Mol Cell Biol. 1993 Jul; 13(7):3975-83.
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Expression of the human retinoblastoma gene product in mouse fibroblasts: effects on cell proliferation and susceptibility to transformation. Exp Cell Res. 1993 Jul; 207(1):99-106.
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Independent regulation of human D-type cyclin gene expression during G1 phase in primary human T lymphocytes. J Biol Chem. 1993 Feb 25; 268(6):4113-9.
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Expression cloning of a cDNA encoding a retinoblastoma-binding protein with E2F-like properties. Cell. 1992 Jul 24; 70(2):351-64.
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The retinoblastoma-susceptibility gene product becomes phosphorylated in multiple stages during cell cycle entry and progression. Proc Natl Acad Sci U S A. 1992 Mar 01; 89(5):1795-8.
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Treatment of myeloid leukemic cells with the phosphatase inhibitor okadaic acid induces cell cycle arrest at either G1/S or G2/M depending on dose. J Cell Physiol. 1992 Mar; 150(3):484-92.
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The transcription factor E2F interacts with the retinoblastoma product and a p107-cyclin A complex in a cell cycle-regulated manner. Cell. 1992 Jan 10; 68(1):157-66.
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Fluorouracil and high-dose leucovorin in previously untreated patients with advanced adenocarcinoma of the pancreas: results of a phase II trial. J Clin Oncol. 1991 Dec; 9(12):2128-33.
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Heterogeneous expression of the product of the retinoblastoma susceptibility gene in primary human leukemia cells. Oncogene. 1991 Aug; 6(8):1343-6.
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Identification of cellular proteins that can interact specifically with the T/E1A-binding region of the retinoblastoma gene product. Cell. 1991 Feb 08; 64(3):521-32.
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Control of junB and extracellular matrix protein expression by transforming growth factor-beta 1 is independent of simian virus 40 T antigen-sensitive growth-sensitive growth-inhibitory events. Mol Cell Biol. 1991 Feb; 11(2):972-8.
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Growth inhibition by TGF-beta linked to suppression of retinoblastoma protein phosphorylation. Cell. 1990 Jul 13; 62(1):175-85.
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Expression and state of phosphorylation of the retinoblastoma susceptibility gene product in cycling and noncycling human hematopoietic cells. Proc Natl Acad Sci U S A. 1990 Apr; 87(7):2770-4.
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The retinoblastoma susceptibility gene product undergoes cell cycle-dependent dephosphorylation and binding to and release from SV40 large T. Cell. 1990 Feb 09; 60(3):387-96.
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The product of the retinoblastoma susceptibility gene has properties of a cell cycle regulatory element. Cell. 1989 Sep 22; 58(6):1085-95.
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An N-terminal transformation-governing sequence of SV40 large T antigen contributes to the binding of both p110Rb and a second cellular protein, p120. Cell. 1989 Jul 28; 58(2):257-67.
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SV40 large T antigen binds preferentially to an underphosphorylated member of the retinoblastoma susceptibility gene product family. Cell. 1989 Jan 13; 56(1):57-65.
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Does the product of the RB-1 locus have a cell cycle regulatory function? Princess Takamatsu Symp. 1989; 20:187-90.
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SV40 large tumor antigen forms a specific complex with the product of the retinoblastoma susceptibility gene. Cell. 1988 Jul 15; 54(2):275-83.
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