Jared H. Rowe, MD, PhD

Jared H. Rowe, MD, PhD

Pediatric Hematology/Oncology

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Contact Information

Fax

617-632-1990

Appointments

617-632-3270 (established patients)
888-733-4662 (new patients)

Biography

Jared H. Rowe, MD, PhD

Jared Rowe, MD, PhD, is an Assistant Professor of Pediatrics at Dana-Farber Cancer Institute and Harvard Medical School, an Attending Physician at the Dana-Farber/Boston Children's Cancer and Blood Disorders Center, and the Principal Investigator of the Rowe Laboratory at Dana-Farber Cancer Institute. He received his MD and PhD degrees from the University of Minnesota in 2014. He then moved to Boston, where he completed his residency at Boston Children’s Hospital in 2017 and his Fellowship in Hematology/Oncology at the Dana-Farber/Boston Children's Cancer and Blood Disorders Center in 2020. Dr. Rowe has been a faculty member at Dana-Farber since 2020 and an Independent Investigator since 2023. 

As a pediatric oncologist and physician-scientist, Dr. Rowe is driven to understand how child development shapes the immune system and to leverage these insights to improve treatments for children with cancer. His work so far has revealed new insights into T cell exhaustion, metabolic control of immunity, and key differences in the transcriptional and signaling programs in neonatal T cells. The Rowe Laboratory uses translational approaches to bridge bench science with the clinic, while remaining centered on the potential for the immune system to enhance both the safety and efficacy of current cancer therapies. 

 

Researcher

Physician

Physician
Assistant Professor of Pediatrics, Harvard Medical School

Clinical Interests

Pediatric Immune Oncology

Board Certification

  • General Pediatrics, 2018
  • Pediatric Hematology/Oncology, 2021

Fellowship

  • Dana-Farber Cancer Institute and Boston Children's Hospital

Residency

  • Boston Children's Hospital

Medical School

  • University of Minnesota Medical School

Research

    The Rowe Laboratory focuses on early life development and its impact on native immunity and adoptive cell therapies for treatment of pediatric malignancies. 

    The human immune system undergoes profound changes during the first years of life. CD8+ T cells from neonates and young infants differ fundamentally from their adult counterparts in differentiation and functional potential. While these differences have traditionally been viewed as deficiencies of an immature system, work from my laboratory shows that early-life CD8+ T cells possess distinct functional properties that, in certain contexts, confer protection that adult T cells cannot match, most strikingly the phenomenon of spontaneous regression in infant neuroblastoma. My research program uses this biology to build a fundamental understanding of immunity in children, with the goal of designing cancer, autoimmune, and infectious disease therapies tailored to the developmental status of an individual's immune system. This work moves in both directions: laboratory discoveries inform clinical strategy, and clinical observations drive new hypotheses about developmental immune biology. 

     

    Locations

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    Dana-Farber Cancer Institute

    450 Brookline Avenue Boston, MA 02215
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    Dana-Farber Cancer Institute

    Location Avtar

    Dana-Farber Cancer Institute

    450 Brookline Avenue Boston, MA 02215
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    42.3374, -71.1083

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