The Guerriero Lab aims to design clinically effective strategies to promote T-cell activation and weaken the immune-suppressive tumor microenvironment to improve immunotherapy response rates in breast cancer patients. They seek to identify tumor-promoting tumor macrophages in breast tumors before and after therapy, elucidate their molecular and metabolic regulation that promotes immune suppression and therapy-resistance and determine how tumor macrophage phenotype, metabolism and function can be modulated for anti-tumor responses. The overall goal is to accelerate breast cancer immunotherapy by harnessing tumor associated macrophages.