Dr. Joseph Mancias is a radiation oncologist in the Gastrointestinal Oncology disease center at the Dana-Farber Brigham Cancer Center. He specializes in the care of patients with gastrointestinal cancers and runs an independent laboratory at the Dana-Farber Cancer Institute focused on the biology of pancreatic cancer.
He received his medical and graduate degrees as part of the Tri-Institutional Weill Cornell/Rockefeller/Sloan-Kettering M.D.-Ph.D. Program earning a Ph.D. degree from the Weill Cornell Graduate School of Medical Sciences and his M.D. from Weill Cornell Medical College. He performed his internship in Internal Medicine at Brigham and Women’s Hospital followed by a residency in Radiation Oncology in the combined Harvard Radiation Oncology Program. He subsequently completed a research fellowship in pancreatic cancer biology at Harvard Medical School and Dana-Farber Cancer Institute.
His research focuses on critical aspects of the biology of pancreatic cancer including selective autophagy, iron metabolism and therapeutic resistance in order to develop novel therapeutic approaches. His lab takes a comprehensive approach combining biochemical, quantitative mass spectrometry-based proteomic, gene editing, cell biological, and advanced modeling techniques to further our understanding of pancreatic cancer.