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Kevin H. Kensler, ScD


Medical Oncology


Researcher

  • Instructor in Medicine, Harvard Medical School

Contact Information

  • Office Phone Number617-632-3048

Bio

Dr. Kensler received his ScD in Epidemiology from the Harvard T.H. Chan School of Public Health in 2018 and subsequently completed his postdoctoral training in the Division of Population Sciences at Dana-Farber Cancer Institute. Dr. Kensler joined the faculty of the Division of Population Sciences as an Instructor in Medicine in 2020. His research focuses on the biologic, socioeconomic, behavioral, and environmental drivers of cancer health disparities.

Recent Awards:

  • NCI Pathway to Independence Award, 2020-2024
  • Ruth L. Kirschstein National Research Service Award for Postdoctoral Fellows, 2019-2020
  • Ruth L. Kirschstein National Research Service Award for Predoctoral Fellows, 2015-2018

Research

My research focuses on the biologic, socioeconomic, behavioral, and environmental drivers of cancer health disparities.
The growing burden of cancer due to population aging and changing risk factors represents one of our largest public health challenges, and I aim to engage in research to mitigate this burden. I have a profound interest in the molecular epidemiology of cancer, which contributes to our understanding of the mechanisms of carcinogenesis and cancer progression, thereby leading to the development of new prevention strategies or informing novel therapeutic approaches. The burden of cancer also falls unequally within populations such that addressing cancer health disparities is a critical challenge for improving public health. I apply the tools of molecular epidemiology to understand how tumor heterogeneity contributes to disparities in breast and prostate cancer outcomes, so as to inform interventions that can ameliorate the burden of cancer and advance health equity.

Tegally H, Kensler KH, Mungloo-Dilmohamud Z, Ghoorah AW, Rebbeck TR, Baichoo S. Discovering novel driver mutations from pan-cancer analysis of mutational and gene expression profiles. PLoS One. 2020; 15(11):e0242780.
View in: PubMed

Kensler KH, Pernar CH, Mahal BA, Nguyen PL, Trinh QD, Kibel AS, Rebbeck TR. Racial/ethnic variation in PSA testing and prostate cancer incidence following the 2012 U.S.P.S.T.F. recommendation. J Natl Cancer Inst. 2020 Nov 04.
View in: PubMed

Awasthi S, Berglund A, Abraham-Miranda J, Rounbehler RJ, Kensler K, Serna A, Vidal A, You S, Freeman MR, Davicioni E, Liu Y, Karnes RJ, Klein EA, Den RB, Trock BJ, Campbell JD, Einstein DJ, Gupta R, Balk S, Lal P, Park JY, Cleveland JL, Rebbeck TR, Freedland SJ, Yamoah K. Comparative Genomics Reveals Distinct Immune-oncologic Pathways in African American Men with Prostate Cancer. Clin Cancer Res. 2021 Jan 01; 27(1):320-329.
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Kensler KH, Liu EZF, Wetstein SC, Onken AM, Luffman CI, Baker GM, Collins LC, Schnitt SJ, Bret-Mounet VC, Veta M, Pluim JPW, Liu Y, Colditz GA, Eliassen AH, Hankinson SE, Tamimi RM, Heng YJ. Automated Quantitative Measures of Terminal Duct Lobular Unit Involution and Breast Cancer Risk. Cancer Epidemiol Biomarkers Prev. 2020 Nov; 29(11):2358-2368.
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Mahal BA, Alshalalfa M, Kensler KH, Chowdhury-Paulino I, Kantoff P, Mucci LA, Schaeffer EM, Spratt D, Yamoah K, Nguyen PL, Rebbeck TR. Racial Differences in Genomic Profiling of Prostate Cancer. N Engl J Med. 2020 09 10; 383(11):1083-1085.
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Wetstein SC, Onken AM, Luffman C, Baker GM, Pyle ME, Kensler KH, Liu Y, Bakker B, Vlutters R, van Leeuwen MB, Collins LC, Schnitt SJ, Pluim JPW, Tamimi RM, Heng YJ, Veta M. Deep learning assessment of breast terminal duct lobular unit involution: Towards automated prediction of breast cancer risk. PLoS One. 2020; 15(4):e0231653.
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Peng C, Heng YJ, Lu D, DuPre NC, Kensler KH, Glass K, Zeleznik OA, Kraft P, Feldman D, Hankinson SE, Rexrode K, Eliassen AH, Tamimi RM. Prediagnostic 25-Hydroxyvitamin D Concentrations in Relation to Tumor Molecular Alterations and Risk of Breast Cancer Recurrence. Cancer Epidemiol Biomarkers Prev. 2020 06; 29(6):1253-1263.
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Yuan J, Kensler KH, Hu Z, Zhang Y, Zhang T, Jiang J, Xu M, Pan Y, Long M, Montone KT, Tanyi JL, Fan Y, Zhang R, Hu X, Rebbeck TR, Zhang L. Integrative comparison of the genomic and transcriptomic landscape between prostate cancer patients of predominantly African or European genetic ancestry. PLoS Genet. 2020 02; 16(2):e1008641.
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Kensler KH, Rebbeck TR. Cancer Progress and Priorities: Prostate Cancer. Cancer Epidemiol Biomarkers Prev. 2020 02; 29(2):267-277.
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Chen JG, Johnson J, Egner P, Ng D, Zhu J, Wang JB, Xue XF, Sun Y, Zhang YH, Lu LL, Chen YS, Wu Y, Zhu YR, Carmella S, Hecht S, Jacobson L, Muñoz A, Kensler K, Rule A, Fahey J, Kensler T, Groopman J. Dose-dependent detoxication of the airborne pollutant benzene in a randomized trial of broccoli sprout beverage in Qidong, China. Am J Clin Nutr. 2019 09 01; 110(3):675-684.
View in: PubMed

Kensler KH, Poole EM, Heng YJ, Collins LC, Glass B, Beck AH, Hazra A, Rosner BA, Eliassen AH, Hankinson SE, Winer EP, Brown M, Tamimi RM. Androgen Receptor Expression and Breast Cancer Survival: Results From the Nurses' Health Studies. J Natl Cancer Inst. 2019 07 01; 111(7):700-708.
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Kensler KH, Regan MM, Heng YJ, Baker GM, Pyle ME, Schnitt SJ, Hazra A, Kammler R, Thürlimann B, Colleoni M, Viale G, Brown M, Tamimi RM. Prognostic and predictive value of androgen receptor expression in postmenopausal women with estrogen receptor-positive breast cancer: results from the Breast International Group Trial 1-98. Breast Cancer Res. 2019 02 22; 21(1):30.
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Kensler KH, Eliassen AH, Rosner BA, Hankinson SE, Brown M, Tamimi RM. Pre-diagnostic sex hormone levels and survival among breast cancer patients. Breast Cancer Res Treat. 2019 Apr; 174(3):749-758.
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Kensler KH, Sankar VN, Wang J, Zhang X, Rubadue CA, Baker GM, Parker JS, Hoadley KA, Stancu AL, Pyle ME, Collins LC, Hunter DJ, Eliassen AH, Hankinson SE, Tamimi RM, Heng YJ. PAM50 Molecular Intrinsic Subtypes in the Nurses' Health Study Cohorts. Cancer Epidemiol Biomarkers Prev. 2019 04; 28(4):798-806.
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Yuan J, Hu Z, Mahal BA, Zhao SD, Kensler KH, Pi J, Hu X, Zhang Y, Wang Y, Jiang J, Li C, Zhong X, Montone KT, Guan G, Tanyi JL, Fan Y, Xu X, Morgan MA, Long M, Zhang Y, Zhang R, Sood AK, Rebbeck TR, Dang CV, Zhang L. Integrated Analysis of Genetic Ancestry and Genomic Alterations across Cancers. Cancer Cell. 2018 10 08; 34(4):549-560.e9.
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Kensler KH, Beca F, Baker GM, Heng YJ, Beck AH, Schnitt SJ, Hazra A, Rosner BA, Eliassen AH, Hankinson SE, Brown M, Tamimi RM. Androgen receptor expression in normal breast tissue and subsequent breast cancer risk. NPJ Breast Cancer. 2018; 4:33.
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Beca F, Kensler K, Glass B, Schnitt SJ, Tamimi RM, Beck AH. EZH2 protein expression in normal breast epithelium and risk of breast cancer: results from the Nurses' Health Studies. Breast Cancer Res. 2017 03 02; 19(1):21.
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Egner PA, Chen JG, Zarth AT, Ng DK, Wang JB, Kensler KH, Jacobson LP, Muñoz A, Johnson JL, Groopman JD, Fahey JW, Talalay P, Zhu J, Chen TY, Qian GS, Carmella SG, Hecht SS, Kensler TW. Rapid and sustainable detoxication of airborne pollutants by broccoli sprout beverage: results of a randomized clinical trial in China. Cancer Prev Res (Phila). 2014 Aug; 7(8):813-823.
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Kensler KH, Slocum SL, Chartoumpekis DV, Dolan PM, Johnson NM, Ilic Z, Crawford DR, Sell S, Groopman JD, Kensler TW, Egner PA. Genetic or pharmacologic activation of Nrf2 signaling fails to protect against aflatoxin genotoxicity in hypersensitive GSTA3 knockout mice. Toxicol Sci. 2014 Jun; 139(2):293-300.
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Fiala JL, Egner PA, Wiriyachan N, Ruchirawat M, Kensler KH, Wogan GN, Groopman JD, Croy RG, Essigmann JM. Sulforaphane-mediated reduction of aflatoxin B1-N7-guanine in rat liver DNA: impacts of strain and sex. Toxicol Sci. 2011 May; 121(1):57-62.
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Research Departments:

Location

Dana-Farber Cancer Institute
450 Brookline Ave
Dana Building 1109
Boston, MA 02215
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