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Lee M. Nadler, MD


Medical Oncology

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Lee M. Nadler, MD

Physician

  • Senior Vice President, Experimental Medicine
  • Physician
  • PMC Chair
  • Virginia and D.K. Ludwig Professor of Medicine, Harvard Medical School

Centers/Programs

Clinical Interests

  • Bone marrow transplant
  • Immunotherapy
  • Lymphoma

Diseases Treated

  • Lymphoma, Hodgkin
  • Lymphoma, Non-Hodgkin

Contact Information

  • Office Phone Number617-632-3331
  • Fax617-632-3541

Bio

Dr. Nadler received his MD from Harvard Medical School in 1973. After residency training at Columbia-Presbyterian Medical Center and training at the National Cancer Institute in tumor immunology, he completed a medical oncology fellowship at DFCI, where he joined the staff in 1980. During his tenure at DFCI, he has served as chief and chair of several departments.

Board Certification:

  • Internal Medicine, 1976

Fellowship:

  • Dana-Farber Cancer Institute, Medical Oncology
  • National Cancer Institute, Immunology

Residency:

  • Columbia-Presbyterian Hospital, Internal Medicine

Medical School:

  • Harvard Medical School

Recent Awards:

  • Richard and Hinda Rosenthal Foundation Award, AACR 1998
  • Association of American Physicians 2000
  • American Society for Clinical Investigation 1989
  • Joseph H. Burchenal Clinical Research Award, AACR 2002
  • Virginia and D.K. Ludwig Professor 2002

Research

Induction of Alloantigen-Specific Anergy for Allogeneic HSCT and Antitumor Immunity

Our laboratory focuses on translational bench-to-bedside and bedside-to-bench research. First, we are investigating the mechanisms of tolerance induction to improve the outcome of allogeneic stem cell transplantation. Second, we are attempting to induce antigen-specific tumor immunity. Our studies of anergy and tolerance are direct extensions of our discovery and characterization of the B7 family of costimulatory molecules. Blockade of the B7 family is both necessary and sufficient to induce alloantigen-specific anergy. We have shown that anergy is an active signaling process. Following extensive preclinical studies, we embarked on a clinical trial. The objective of this study was to induce tolerance of donor T cell antigens specific to host antigen anergy ex vivo through blockade of B7 costimulation. Induction of antigen-specific tolerance would eliminate or sharply curtail the need for nonspecific prophylactic immunosuppression and for the subsequent toxic and often inefficacious treatment of severe acute or chronic graft-versus-host disease (GVHD). Similarly, retention of a mature T cell component in the graft with its residual repertoire intact could facilitate engraftment and eliminate the risks of lymphoproliferative disease and increased relapse after transplant that currently attend global T cell depletion strategies. We have completed two phase I studies using anti-B7 blockade to induce alloantigen-specific anergy in patients undergoing haploidentical human stem cell transplantation. We have demonstrated feasibility, less than expected incidence of GVHD, and fewer than expected infections. Going forward, we are focusing on the retention of pathogen and tumor-specific immunity. Our studies in antigen-specific antitumor immunity have focused on the identification and clinical translational of universal tumor antigens. We have shown that hTERT and CYP1B1 are expressed in most human tumors with limited expression in normal tissues. Human T cells directed against these antigens exist in the T cell repertoire of normal individuals and patients with cancer. T cells directed against these antigens can be generated ex vivo, and these T cells can kill human tumor cells in an HLA-restricted, antigen-restricted fashion. Each of these universal tumor antigens has been taken to the clinic to treat patients with advanced-stage multiply relapsed cancer. A phase I trial of hTERT peptide-pulsed dendritic cells demonstrated feasibility, safety, and the generation of peptide-specific T cells. We are now extending this trial. We have also conducted a DNA vaccine trial of CYP1B1. Again, no significant toxicities were observed and patients generated anti-CYP1B1 specific T cells.

Individual and cumulative health afflictions are associated with greater impairment in physical and mental function in former professional American style football players. PM R. 2022 01; 14(1):30-39.
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Development of a Coronavirus Disease 2019 (COVID-19) Application Ontology for the Accrual to Clinical Trials (ACT) network. JAMIA Open. 2021 Apr; 4(2):ooab036.
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Development of a COVID-19 Application Ontology for the ACT Network. medRxiv. 2021 Apr 14.
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Modifiable Risk Factors for Poor Cognitive Function in Former American-Style Football Players: Findings from the Harvard Football Players Health Study. J Neurotrauma. 2021 01 15; 38(2):189-195.
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Scale-up of the Accrual to Clinical Trials (ACT) network across the Clinical and Translational Science Award Consortium: a mixed-methods evaluation of the first 18 months. J Clin Transl Sci. 2020 Jun 30; 4(6):515-528.
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Premortem Chronic Traumatic Encephalopathy Diagnoses in Professional Football. Ann Neurol. 2020 07; 88(1):106-112.
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Self-Reported Cognitive Function and Mental Health Diagnoses among Former Professional American-Style Football Players. J Neurotrauma. 2020 04 15; 37(8):1021-1028.
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Association of Concussion Symptoms With Testosterone Levels and Erectile Dysfunction in Former Professional US-Style Football Players. JAMA Neurol. 2019 12 01; 76(12):1428-1438.
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Exposure to American Football and Neuropsychiatric Health in Former National Football League Players: Findings From the Football Players Health Study. Am J Sports Med. 2019 10; 47(12):2871-2880.
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The SMART IRB platform: A national resource for IRB review for multisite studies. J Clin Transl Sci. 2019 Aug; 3(4):129-139.
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The Football Players' Health Study at Harvard University: Design and objectives. Am J Ind Med. 2019 08; 62(8):643-654.
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Multisystem afflictions in former National Football League players. Am J Ind Med. 2019 08; 62(8):655-662.
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Mortality Among Professional American-Style Football Players and Professional American Baseball Players. JAMA Netw Open. 2019 05 03; 2(5):e194223.
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Defining Exposures in Professional Football: Professional American-Style Football Players as an Occupational Cohort. Orthop J Sports Med. 2019 Feb; 7(2):2325967119829212.
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Relation of Anterior Cruciate Ligament Tears to Potential Chronic Cardiovascular diseases. Am J Cardiol. 2018 12 01; 122(11):1879-1884.
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Accrual to Clinical Trials (ACT): A Clinical and Translational Science Award Consortium Network. JAMIA Open. 2018 Oct; 1(2):147-152.
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Infusion of Alloanergized Donor Lymphocytes after CD34-selected Haploidentical Myeloablative Hematopoietic Stem Cell Transplantation. Clin Cancer Res. 2018 09 01; 24(17):4098-4109.
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American-Style Football and Cardiovascular Health. J Am Heart Assoc. 2018 04 04; 7(8).
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Alloanergization of human T cells results in expansion of alloantigen-specific CD8(+) CD28(-) suppressor cells. Am J Transplant. 2014 Feb; 14(2):305-18.
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Ex vivo alloanergization with belatacept: a strategy to selectively modulate alloresponses after transplantation. Cell Transplant. 2012; 21(9):2047-61.
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Preparedness of the CTSA's structural and scientific assets to support the mission of the National Center for Advancing Translational Sciences (NCATS). Clin Transl Sci. 2012 Apr; 5(2):121-9.
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Ex vivo expansion of human CD8+ T cells using autologous CD4+ T cell help. PLoS One. 2012; 7(1):e30229.
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IL-21 can supplement suboptimal Lck-independent MAPK activation in a STAT-3-dependent manner in human CD8(+) T cells. J Immunol. 2012 Feb 15; 188(4):1609-19.
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Induction of HLA-DP4-restricted anti-survivin Th1 and Th2 responses using an artificial antigen-presenting cell. Clin Cancer Res. 2011 Aug 15; 17(16):5392-401.
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Aberrant expression of functional BAFF-system receptors by malignant B-cell precursors impacts leukemia cell survival. PLoS One. 2011; 6(6):e20787.
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Establishment of antitumor memory in humans using in vitro-educated CD8+ T cells. Sci Transl Med. 2011 Apr 27; 3(80):80ra34.
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Induction of alloantigen-specific anergy in human peripheral blood mononuclear cells by alloantigen stimulation with co-stimulatory signal blockade. J Vis Exp. 2011 Mar 14; (49).
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A phase III study of anti-B4-blocked ricin as adjuvant therapy post-autologous bone marrow transplant: CALGB 9254. Leuk Lymphoma. 2011 Apr; 52(4):587-96.
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Targeting of active mTOR inhibits primary leukemia T cells and synergizes with cytotoxic drugs and signaling inhibitors. Exp Hematol. 2011 Apr; 39(4):457-472.e3.
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A panel of human cell-based artificial APC enables the expansion of long-lived antigen-specific CD4+ T cells restricted by prevalent HLA-DR alleles. Int Immunol. 2010 Nov; 22(11):863-73.
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Combining CD19 redirection and alloanergization to generate tumor-specific human T cells for allogeneic cell therapy of B-cell malignancies. Cancer Res. 2010 May 15; 70(10):3915-24.
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Expansion of allospecific regulatory T cells after anergized, mismatched bone marrow transplantation. Sci Transl Med. 2009 Oct 07; 1(1):1ra3.
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Cyclin D1-specific cytotoxic T lymphocytes are present in the repertoire of cancer patients: implications for cancer immunotherapy. Clin Cancer Res. 2008 Oct 15; 14(20):6574-9.
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Dissociation of its opposing immunologic effects is critical for the optimization of antitumor CD8+ T-cell responses induced by interleukin 21. Clin Cancer Res. 2008 Oct 01; 14(19):6125-36.
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Induction of alloanergy in human donor T cells without loss of pathogen or tumor immunity. Transplantation. 2008 Sep 27; 86(6):854-64.
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CpG oligodeoxynucleotides alter lymphocyte and dendritic cell trafficking in humans. Clin Cancer Res. 2008 Sep 01; 14(17):5626-34.
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High-throughput gene expression profiling of memory differentiation in primary human T cells. BMC Immunol. 2008 Aug 01; 9:44.
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Identification of an evolutionarily conserved transcriptional signature of CD8 memory differentiation that is shared by T and B cells. J Immunol. 2008 Aug 01; 181(3):1859-68.
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Outcome of alloanergized haploidentical bone marrow transplantation after ex vivo costimulatory blockade: results of 2 phase 1 studies. Blood. 2008 Sep 15; 112(6):2232-41.
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Interleukin-4 stimulates proliferation and growth of T-cell acute lymphoblastic leukemia cells by activating mTOR signaling. Leukemia. 2009 Jan; 23(1):206-8.
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Lee Marshall Nadler, MD: a conversation with the editor. Proc (Bayl Univ Med Cent). 2007 Oct; 20(4):381-9.
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Long-term survival after autologous bone marrow transplantation for follicular lymphoma in first remission. Biol Blood Marrow Transplant. 2007 Sep; 13(9):1057-65.
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Myeloablative therapy with autologous bone marrow transplantation for follicular lymphoma at the time of second or subsequent remission: long-term follow-up. J Clin Oncol. 2007 Jun 20; 25(18):2554-9.
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Long-lived antitumor CD8+ lymphocytes for adoptive therapy generated using an artificial antigen-presenting cell. Clin Cancer Res. 2007 Mar 15; 13(6):1857-67.
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Identification of an immunogenic CD8+ T-cell epitope derived from gamma-globin, a putative tumor-associated antigen for juvenile myelomonocytic leukemia. Blood. 2006 Oct 15; 108(8):2662-8.
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Efficient presentation of naturally processed HLA class I peptides by artificial antigen-presenting cells for the generation of effective antitumor responses. Clin Cancer Res. 2006 May 15; 12(10):2967-75.
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Leukemia-stimulated bone marrow endothelium promotes leukemia cell survival. Exp Hematol. 2006 May; 34(5):610-21.
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Rapid, reliable and inexpensive quality assessment of biotinylated cRNA. Braz J Med Biol Res. 2006 May; 39(5):589-93.
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CD40-activated B cells express full lymph node homing triad and induce T-cell chemotaxis: potential as cellular adjuvants. Blood. 2006 Apr 01; 107(7):2786-9.
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Gene expression profiling identifies BAX-delta as a novel tumor antigen in acute lymphoblastic leukemia. Cancer Res. 2005 Nov 01; 65(21):10050-8.
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Engagement of CD83 ligand induces prolonged expansion of CD8+ T cells and preferential enrichment for antigen specificity. Blood. 2006 Feb 15; 107(4):1528-36.
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Proangiogenic stimulation of bone marrow endothelium engages mTOR and is inhibited by simultaneous blockade of mTOR and NF-kappaB. Blood. 2006 Jan 01; 107(1):285-92.
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Rare naturally occurring immune responses to three epitopes from the widely expressed tumour antigens hTERT and CYP1B1 in multiple myeloma patients. Clin Exp Immunol. 2005 Sep; 141(3):558-62.
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Autologous and allogeneic stem cell transplantations for poor-risk chronic lymphocytic leukemia. Blood. 2005 Dec 15; 106(13):4389-96.
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Phase I/II combined chemoimmunotherapy with carcinoembryonic antigen-derived HLA-A2-restricted CAP-1 peptide and irinotecan, 5-fluorouracil, and leucovorin in patients with primary metastatic colorectal cancer. Clin Cancer Res. 2005 Aug 15; 11(16):5993-6001.
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Unexpected association between induction of immunity to the universal tumor antigen CYP1B1 and response to next therapy. Clin Cancer Res. 2005 Jun 15; 11(12):4430-6.
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Identification of a new HLA-A*0201-restricted cryptic epitope from CYP1B1. Int J Cancer. 2005 Jun 10; 115(2):333-6.
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Antigen-specific T-cell memory is preserved in children treated for acute lymphoblastic leukemia. Blood. 2005 Sep 01; 106(5):1749-54.
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Increasing incidence of late second malignancies after conditioning with cyclophosphamide and total-body irradiation and autologous bone marrow transplantation for non-Hodgkin's lymphoma. J Clin Oncol. 2005 Apr 01; 23(10):2208-14.
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Failure to define window of time for autologous tumor vaccination in patients with newly diagnosed or relapsed acute lymphoblastic leukemia. Exp Hematol. 2005 Mar; 33(3):286-94.
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Presence of anti-kinectin and anti-PMS1 antibodies in Japanese aplastic anaemia patients. Br J Haematol. 2005 Jan; 128(2):221-3.
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Common gamma chain-signaling cytokines promote proliferation of T-cell acute lymphoblastic leukemia. Haematologica. 2004 Dec; 89(12):1459-67.
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Measuring T cell immunity to influenza vaccination in children after haemopoietic stem cell transplantation. Br J Haematol. 2004 Nov; 127(3):322-5.
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Combination immunotherapy with a CpG oligonucleotide (1018 ISS) and rituximab in patients with non-Hodgkin lymphoma: increased interferon-alpha/beta-inducible gene expression, without significant toxicity. Blood. 2005 Jan 15; 105(2):489-95.
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Activation of PI3K is indispensable for interleukin 7-mediated viability, proliferation, glucose use, and growth of T cell acute lymphoblastic leukemia cells. J Exp Med. 2004 Sep 06; 200(5):659-69.
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pH-triggered microparticles for peptide vaccination. J Immunol. 2004 Aug 15; 173(4):2578-85.
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Correspondence re R. Lapointe et al., CD40-stimulated B lymphocytes pulsed with tumor antigens are effective antigen-presenting cells that can generate specific T cells. Cancer Res 2003;63:2836-43. Cancer Res. 2004 Jun 01; 64(11):4055-6; author reply 4056-7.
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Autologous bone marrow transplantation for marginal zone non-Hodgkin's lymphoma. Leuk Lymphoma. 2004 Feb; 45(2):315-20.
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Vaccination of cancer patients against telomerase induces functional antitumor CD8+ T lymphocytes. Clin Cancer Res. 2004 Feb 01; 10(3):828-39.
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IL-7-dependent human leukemia T-cell line as a valuable tool for drug discovery in T-ALL. Blood. 2004 Mar 01; 103(5):1891-900.
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Autoantibodies frequently detected in patients with aplastic anemia. Blood. 2003 Dec 15; 102(13):4567-75.
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Differential localization and function of ADP-ribosylation factor-6 in anergic human T cells: a potential marker for their identification. J Immunol. 2003 Aug 15; 171(4):1691-6.
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The shared tumor-associated antigen cytochrome P450 1B1 is recognized by specific cytotoxic T cells. Blood. 2003 Nov 01; 102(9):3287-94.
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Viral antigen-specific CD8+ T-cell responses are impaired in multiple myeloma. Br J Haematol. 2003 Jun; 121(6):842-8.
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MUC1-like tandem repeat proteins are broadly immunogenic in cancer patients. Cancer Immun. 2003 Mar 17; 3:3.
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From genomics to cancer vaccines: patient-tailored or universal vaccines? Curr Opin Mol Ther. 2002 Dec; 4(6):572-6.
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cAMP inhibits both Ras and Rap1 activation in primary human T lymphocytes, but only Ras inhibition correlates with blockade of cell cycle progression. Blood. 2003 Feb 01; 101(3):998-1006.
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HER-2/neu and hTERT cryptic epitopes as novel targets for broad spectrum tumor immunotherapy. J Immunol. 2002 Jun 01; 168(11):5900-6.
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Human primary and memory cytotoxic T lymphocyte responses are efficiently induced by means of CD40-activated B cells as antigen-presenting cells: potential for clinical application. Blood. 2002 May 01; 99(9):3319-25.
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CD28 costimulation mediates down-regulation of p27kip1 and cell cycle progression by activation of the PI3K/PKB signaling pathway in primary human T cells. J Immunol. 2002 Mar 15; 168(6):2729-36.
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Blockade of B7/CD28 in mixed lymphocyte reaction cultures results in the generation of alternatively activated macrophages, which suppress T-cell responses. Blood. 2002 Feb 15; 99(4):1465-73.
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Tob is a negative regulator of activation that is expressed in anergic and quiescent T cells. Nat Immunol. 2001 Dec; 2(12):1174-82.
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Equivalent induction of telomerase-specific cytotoxic T lymphocytes from tumor-bearing patients and healthy individuals. Cancer Res. 2001 Dec 01; 61(23):8366-70.
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Characterization of HLA-A3-restricted cytotoxic T lymphocytes reactive against the widely expressed tumor antigen telomerase. Clin Cancer Res. 2001 Nov; 7(11):3343-8.
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Identification of HER-2/neu immunogenic epitopes presented by renal cell carcinoma and other human epithelial tumors. Eur J Immunol. 2001 Nov; 31(11):3261-70.
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CD40 activation of carcinoma cells increases expression of adhesion and major histocompatibility molecules but fails to induce either CD80/CD86 expression or T cell alloreactivity. Int J Oncol. 2001 Oct; 19(4):791-8.
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Interleukin-7 promotes survival and cell cycle progression of T-cell acute lymphoblastic leukemia cells by down-regulating the cyclin-dependent kinase inhibitor p27(kip1). Blood. 2001 Sep 01; 98(5):1524-31.
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Chemoattractants MDC and TARC are secreted by malignant B-cell precursors following CD40 ligation and support the migration of leukemia-specific T cells. Blood. 2001 Aug 01; 98(3):533-40.
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A pilot study of combined immunotherapy with autologous adoptive tumour-specific T-cell transfer, vaccination with CD40-activated malignant B cells and interleukin 2. Br J Haematol. 2001 May; 113(2):455-60.
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The impact of external beam radiation therapy prior to autologous bone marrow transplantation in patients with non-Hodgkin's lymphoma. Biol Blood Marrow Transplant. 2001; 7(8):446-53.
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Loss of marrow reserve from dose-intensified chemotherapy results in impaired hematopoietic reconstitution after autologous transplantation: CD34(+), CD34(+)38(-), and week-6 CAFC assays predict poor engraftment. Exp Hematol. 2000 Dec; 28(12):1325-33.
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Expression of MHC class II-associated invariant chain (Ii;CD74) in thymic epithelial neoplasms. Appl Immunohistochem Mol Morphol. 2000 Sep; 8(3):210-5.
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Lentiviral vectors for efficient delivery of CD80 and granulocyte-macrophage- colony-stimulating factor in human acute lymphoblastic leukemia and acute myeloid leukemia cells to induce antileukemic immune responses. Blood. 2000 Aug 15; 96(4):1317-26.
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Combination chemotherapy followed by an immunotoxin (anti-B4-blocked ricin) in patients with indolent lymphoma: results of a phase II study. Cancer J. 2000 May-Jun; 6(3):146-50.
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p27kip1 functions as an anergy factor inhibiting interleukin 2 transcription and clonal expansion of alloreactive human and mouse helper T lymphocytes. Nat Med. 2000 Mar; 6(3):290-7.
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Adoptive T-cell therapy for B-cell acute lymphoblastic leukemia: preclinical studies. Blood. 1999 Nov 15; 94(10):3531-40.
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Long-term follow-up of autologous bone marrow transplantation in patients with relapsed follicular lymphoma. Blood. 1999 Nov 15; 94(10):3325-33.
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Outcome in patients with myelodysplastic syndrome after autologous bone marrow transplantation for non-Hodgkin's lymphoma. J Clin Oncol. 1999 Oct; 17(10):3128-35.
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Future strategies toward the cure of indolent B-cell malignancies. Immune recognition and antiself. Semin Hematol. 1999 Oct; 36(4 Suppl 5):9-11.
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A Phase II study of adjuvant therapy with anti-B4-blocked ricin after autologous bone marrow transplantation for patients with relapsed B-cell non-Hodgkin's lymphoma. Clin Cancer Res. 1999 Sep; 5(9):2392-8.
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Transplantation of anergic histoincompatible bone marrow allografts. N Engl J Med. 1999 Jun 03; 340(22):1704-14.
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The telomerase catalytic subunit is a widely expressed tumor-associated antigen recognized by cytotoxic T lymphocytes. Immunity. 1999 Jun; 10(6):673-9.
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Bone marrow transplantation for low-grade lymphoma and chronic lymphocytic leukemia. Semin Hematol. 1999 Apr; 36(2):209-16.
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T cell mediated immunotherapy for B cell lymphoma. J Mol Med (Berl). 1999 Mar; 77(3):322-31.
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Muc-1 core protein is expressed on multiple myeloma cells and is induced by dexamethasone. Blood. 1999 Feb 15; 93(4):1287-98.
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Human non-germinal center B cell interleukin (IL)-12 production is primarily regulated by T cell signals CD40 ligand, interferon gamma, and IL-10: role of B cells in the maintenance of T cell responses. J Exp Med. 1999 Jan 04; 189(1):1-12.
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Human macrophage-derived chemokine (MDC) is strongly expressed following activation of both normal and malignant precursor and mature B cells. Curr Top Microbiol Immunol. 1999; 246:103-10.
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Phase II clinical trial of bolus infusion anti-B4 blocked ricin immunoconjugate in patients with relapsed B-cell non-Hodgkin's lymphoma. Clin Cancer Res. 1998 Nov; 4(11):2599-604.
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Tumor-specific adoptive T-cell therapy for CD40+ B-cell malignancies. Curr Opin Oncol. 1998 Nov; 10(6):542-7.
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No evidence for MUC 1-induced apoptosis. Nat Med. 1998 Oct; 4(10):1093.
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Cloning of BY55, a novel Ig superfamily member expressed on NK cells, CTL, and intestinal intraepithelial lymphocytes. J Immunol. 1998 Sep 15; 161(6):2780-90.
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The BB1 monoclonal antibody recognizes both cell surface CD74 (MHC class II-associated invariant chain) as well as B7-1 (CD80), resolving the question regarding a third CD28/CTLA-4 counterreceptor. J Immunol. 1998 Sep 15; 161(6):2708-15.
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Anti-B4-blocked ricin: a phase II trial of 7 day continuous infusion in patients with multiple myeloma. Br J Haematol. 1998 Jul; 102(2):509-15.
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The leukocyte semaphorin CD100 is expressed in most T-cell, but few B-cell, non-Hodgkin's lymphomas. Am J Pathol. 1998 Jul; 153(1):255-62.
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Predictive value of clonality assays in patients with non-Hodgkin's lymphoma undergoing autologous bone marrow transplant: a single institution study. Blood. 1998 Jun 15; 91(12):4496-503.
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CD6+ T cell-depleted allogeneic bone marrow transplantation for non-Hodgkin's lymphoma. Bone Marrow Transplant. 1998 Jun; 21(12):1177-81.
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High dose therapy and autologous stem cell transplantation in follicular non-Hodgkin's lymphoma. Leuk Lymphoma. 1998 Jan; 28(3-4):219-30.
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Unbalanced expression of bcl-2 family proteins in follicular lymphoma: contribution of CD40 signaling in promoting survival. Blood. 1998 Jan 01; 91(1):244-51.
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High-dose chemoradiotherapy and anti-B-cell monoclonal antibody-purged autologous bone marrow transplantation in mantle-cell lymphoma: no evidence for long-term remission. J Clin Oncol. 1998 Jan; 16(1):13-8.
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Cyclophosphamide, doxorubicin, vincristine, prednisone dose intensification with granulocyte colony-stimulating factor markedly depletes stem cell reserve for autologous bone marrow transplantation. Blood. 1997 Dec 15; 90(12):4996-5001.
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CD40-activated human B cells: an alternative source of highly efficient antigen presenting cells to generate autologous antigen-specific T cells for adoptive immunotherapy. J Clin Invest. 1997 Dec 01; 100(11):2757-65.
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In vivo expression of B7-1 and B7-2 by follicular lymphoma cells can prevent induction of T-cell anergy but is insufficient to induce significant T-cell proliferation. Blood. 1997 Dec 01; 90(11):4297-306.
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Failure of immunologic purging in mantle cell lymphoma assessed by polymerase chain reaction detection of minimal residual disease. Blood. 1997 Nov 15; 90(10):4212-21.
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Maintenance of human T cell anergy: blocking of IL-2 gene transcription by activated Rap1. Science. 1997 Oct 03; 278(5335):124-8.
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Induction of T cell clonal anergy results in resistance, whereas CD28-mediated costimulation primes for susceptibility to Fas- and Bax-mediated programmed cell death. J Immunol. 1997 Oct 01; 159(7):3156-67.
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Recent advances in lymphoma biology. Curr Opin Oncol. 1997 Sep; 9(5):403-12.
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Prediction of therapy-related acute myelogenous leukemia (AML) and myelodysplastic syndrome (MDS) after autologous bone marrow transplant (ABMT) for lymphoma. Am J Hematol. 1997 Sep; 56(1):45-51.
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Ex vivo generation of human anti-pre-B leukemia-specific autologous cytolytic T cells. Blood. 1997 Jul 15; 90(2):549-61.
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Autologous tumor infiltrating T cells cytotoxic for follicular lymphoma cells can be expanded in vitro. Blood. 1997 May 15; 89(10):3806-16.
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Biologic response modifiers in acute lymphoblastic leukemia. Leukemia. 1997 May; 11 Suppl 4:S31-3.
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CD6-depleted allogeneic bone marrow transplantation for acute leukemia in first complete remission. Blood. 1997 Apr 15; 89(8):3039-47.
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CD6+ T cell depleted allogeneic bone marrow transplantation from genotypically HLA nonidentical related donors. Biol Blood Marrow Transplant. 1997 Apr; 3(1):11-7.
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Breast cancer-associated antigen, DF3/MUC1, induces apoptosis of activated human T cells. Nat Med. 1996 Dec; 2(12):1367-70.
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Lymphoma classification--the gap between biology and clinical management is closing. Blood. 1996 Dec 01; 88(11):4085-9.
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Human CD100, a novel leukocyte semaphorin that promotes B-cell aggregation and differentiation. Proc Natl Acad Sci U S A. 1996 Oct 15; 93(21):11780-5.
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The role of B7-1/B7-2:CD28/CLTA-4 pathways in the prevention of anergy, induction of productive immunity and down-regulation of the immune response. Immunol Rev. 1996 Oct; 153:5-26.
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High-dose therapy and autologous bone marrow transplantation in patients with follicular lymphoma during first remission. Blood. 1996 Oct 01; 88(7):2780-6.
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Innovative strategies for the treatment of CLL. Leuk Lymphoma. 1996 Oct; 22 Suppl 2:53-64.
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Eradication of polymerase chain reaction-detectable chronic lymphocytic leukemia cells is associated with improved outcome after bone marrow transplantation. Blood. 1996 Sep 15; 88(6):2228-35.
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R24 anti-GD3 ganglioside antibody can induce costimulation and prevent the induction of alloantigen-specific T cell clonal anergy. Eur J Immunol. 1996 Sep; 26(9):2149-54.
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Sources and sequelae of bacterial contamination of hematopoietic stem cell components: implications for the safety of hematotherapy and graft engineering. Transfusion. 1996 Sep; 36(9):782-8.
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Differential association of protein tyrosine kinases with the T cell receptor is linked to the induction of anergy and its prevention by B7 family-mediated costimulation. J Exp Med. 1996 Aug 01; 184(2):365-76.
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Pre-B acute lymphoblastic leukemia cells may induce T-cell anergy to alloantigen. Blood. 1996 Jul 01; 88(1):41-8.
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B7-mediated costimulation and the immune response. Blood Rev. 1996 Jun; 10(2):111-27.
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Complete blockade of B7 family-mediated costimulation is necessary to induce human alloantigen-specific anergy: a method to ameliorate graft-versus-host disease and extend the donor pool. Blood. 1996 Jun 01; 87(11):4887-93.
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A cell type-specific enhancer in the human B7.1 gene regulated by NF-kappaB. J Exp Med. 1996 Mar 01; 183(3):777-89.
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B7-1 is superior to B7-2 costimulation in the induction and maintenance of T cell-mediated antileukemia immunity. Further evidence that B7-1 and B7-2 are functionally distinct. J Immunol. 1996 Feb 01; 156(3):1126-31.
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Differential expression of alternate mB7-2 transcripts. J Immunol. 1995 Dec 15; 155(12):5490-7.
View in: PubMed

Follicular lymphomas can be induced to present alloantigen efficiently: a conceptual model to improve their tumor immunogenicity. Proc Natl Acad Sci U S A. 1995 Aug 29; 92(18):8200-4.
View in: PubMed

Both CD28 ligands CD80 (B7-1) and CD86 (B7-2) activate phosphatidylinositol 3-kinase, and wortmannin reveals heterogeneity in the regulation of T cell IL-2 secretion. Int Immunol. 1995 Jun; 7(6):957-66.
View in: PubMed

Role of B7-1 in mediating an immune response to myeloid leukemia cells. Blood. 1995 May 01; 85(9):2507-15.
View in: PubMed

B7-1 and B7-2 do not deliver identical costimulatory signals, since B7-2 but not B7-1 preferentially costimulates the initial production of IL-4. Immunity. 1995 May; 2(5):523-32.
View in: PubMed

Monoclonal antibody-purged bone marrow transplantation therapy for multiple myeloma. Leuk Lymphoma. 1995 Mar; 17(1-2):87-93.
View in: PubMed

The critical role of CD28 signalling in the prevention of human T-cell anergy. Res Immunol. 1995 Mar-Apr; 146(3):140-9.
View in: PubMed

28-kDa mammalian heat shock protein, a novel substrate of a growth regulatory protease involved in differentiation of human leukemia cells. J Biol Chem. 1995 Jan 20; 270(3):1003-6.
View in: PubMed

Ciprofloxacin versus trimethoprim/sulfamethoxazole for prophylaxis of bacterial infections in bone marrow transplant recipients: a randomized, controlled trial. J Clin Oncol. 1995 Jan; 13(1):239-50.
View in: PubMed

Detection of minimal residual disease. Cancer Treat Res. 1995; 76:249-70.
View in: PubMed

Characterization of the murine B7-1 genomic locus reveals an additional exon encoding an alternative cytoplasmic domain and a chromosomal location of chromosome 16, band B5. J Immunol. 1994 Dec 01; 153(11):5038-48.
View in: PubMed

Pivotal role of the B7:CD28 pathway in transplantation tolerance and tumor immunity. Blood. 1994 Nov 15; 84(10):3261-82.
View in: PubMed

Prevention of T cell anergy by signaling through the gamma c chain of the IL-2 receptor. Science. 1994 Nov 11; 266(5187):1039-42.
View in: PubMed

CD2 is involved in maintenance and reversal of human alloantigen-specific clonal anergy. J Exp Med. 1994 Nov 01; 180(5):1665-73.
View in: PubMed

Blockade of the CD28 co-stimulatory pathway: a means to induce tolerance. Curr Opin Immunol. 1994 Oct; 6(5):797-807.
View in: PubMed

Differential up-regulation of the B7-1 and B7-2 costimulatory molecules after Ig receptor engagement by antigen. J Immunol. 1994 Sep 01; 153(5):1990-7.
View in: PubMed

The B7-2 (B70) costimulatory molecule expressed by monocytes and activated B lymphocytes is the CD86 differentiation antigen. Blood. 1994 Sep 01; 84(5):1402-7.
View in: PubMed

Tumor necrosis factor alpha is an autocrine growth factor for normal human B cells. Proc Natl Acad Sci U S A. 1994 Jul 19; 91(15):7007-11.
View in: PubMed

The B7 and CD28 receptor families. Immunol Today. 1994 Jul; 15(7):321-31.
View in: PubMed

Detection of residual lymphoma cells by polymerase chain reaction in peripheral blood is significantly less predictive for relapse than detection in bone marrow. Blood. 1994 Jun 15; 83(12):3800-7.
View in: PubMed

Adhesion of follicular lymphoma cells to lymphoid germinal centers--a potential mechanism of tumor cell homing following autologous transplantation. Leuk Lymphoma. 1994 Mar; 13(1-2):47-52.
View in: PubMed

In vivo expression of the B7 costimulatory molecule by subsets of antigen-presenting cells and the malignant cells of Hodgkin's disease. Blood. 1994 Feb 01; 83(3):793-8.
View in: PubMed

Regulation of the 28 kDa heat shock protein by retinoic acid during differentiation of human leukemic HL-60 cells. FEBS Lett. 1994 Jan 10; 337(2):184-8.
View in: PubMed

Detection of minimal residual disease in patients with lymphomas using the polymerase chain reaction. Important Adv Oncol. 1994; 117-29.
View in: PubMed

Immunotoxin therapy of lymphoid neoplasms. Semin Hematol. 1994 Jan; 31(1):88-97.
View in: PubMed

Myeloablative therapy with autologous bone marrow transplantation as consolidation therapy for follicular lymphoma. Ann Oncol. 1994; 5 Suppl 2:143-6.
View in: PubMed

Activated human B lymphocytes express three CTLA-4 counterreceptors that costimulate T-cell activation. Proc Natl Acad Sci U S A. 1993 Dec 01; 90(23):11059-63.
View in: PubMed

[Failing B7 costimulation engenders a peripheral clonal T-cell anergy in a human antigen-specific model]. Schweiz Med Wochenschr. 1993 Nov 27; 123(47):2255-6.
View in: PubMed

Cloning of B7-2: a CTLA-4 counter-receptor that costimulates human T cell proliferation. Science. 1993 Nov 05; 262(5135):909-11.
View in: PubMed

B7 but not intercellular adhesion molecule-1 costimulation prevents the induction of human alloantigen-specific tolerance. J Exp Med. 1993 Nov 01; 178(5):1753-63.
View in: PubMed

Characterization of CTLA-4 structure and expression on human T cells. J Immunol. 1993 Oct 01; 151(7):3489-99.
View in: PubMed

Monoclonal antibody therapy for indolent lymphomas. Semin Oncol. 1993 Oct; 20(5 Suppl 5):118-35.
View in: PubMed

Monitoring minimal residual disease. Semin Oncol. 1993 Oct; 20(5 Suppl 5):143-55.
View in: PubMed

Which patients with relapsed non-Hodgkin's lymphoma benefit from high-dose therapy and hematopoietic stem-cell transplantation? J Clin Oncol. 1993 Oct; 11(10):1841-3.
View in: PubMed

Prediction of graft-versus-host disease by phenotypic analysis of early immune reconstitution after CD6-depleted allogeneic bone marrow transplantation. Blood. 1993 Oct 01; 82(7):2216-23.
View in: PubMed

Heat shock protein is a unique marker of growth arrest during macrophage differentiation of HL-60 cells. J Cell Physiol. 1993 Sep; 156(3):619-25.
View in: PubMed

Human T-cell clonal anergy is induced by antigen presentation in the absence of B7 costimulation. Proc Natl Acad Sci U S A. 1993 Jul 15; 90(14):6586-90.
View in: PubMed

Constitutive expression of B7 restores immunogenicity of tumor cells expressing truncated major histocompatibility complex class II molecules. Proc Natl Acad Sci U S A. 1993 Jun 15; 90(12):5687-90.
View in: PubMed

Developments in purging in autotransplantation. Hematol Oncol Clin North Am. 1993 Jun; 7(3):687-715.
View in: PubMed

Bone marrow purging for autologous bone marrow transplantation. Leuk Lymphoma. 1993; 11 Suppl 2:141-8.
View in: PubMed

Purging of autologous bone marrow in the treatment of non-Hodgkin's lymphoma. Important Adv Oncol. 1993; 139-56.
View in: PubMed

Immunotoxin therapy of lymphoma. Cancer Treat Res. 1993; 68:111-31.
View in: PubMed

Effects of cyclosporin A, FK 506, and mycalamide A on the activation of murine CD4+ T cells by the murine B7 antigen. Eur J Immunol. 1993 Jan; 23(1):283-6.
View in: PubMed

The immunological treatment of human marrow in vitro in transplantation biology. Cancer Treat Res. 1993; 64:189-211.
View in: PubMed

Murine B7 antigen provides a sufficient costimulatory signal for antigen-specific and MHC-restricted T cell activation. J Immunol. 1992 Dec 15; 149(12):3802-8.
View in: PubMed

Signalling through the MHC class II cytoplasmic domain is required for antigen presentation and induces B7 expression. Nature. 1992 Nov 19; 360(6401):266-8.
View in: PubMed

Follicular dendritic cells inhibit human B-lymphocyte proliferation. Blood. 1992 Sep 01; 80(5):1284-8.
View in: PubMed

Monoclonal antibody-based therapies of leukemia and lymphoma. Blood. 1992 Aug 15; 80(4):863-78.
View in: PubMed

Bone marrows of non-Hodgkin's lymphoma patients with a bcl-2 translocation can be purged of polymerase chain reaction-detectable lymphoma cells using monoclonal antibodies and immunomagnetic bead depletion. Blood. 1992 Aug 15; 80(4):1083-9.
View in: PubMed

Correlation between in vivo toxicity and preclinical in vitro parameters for the immunotoxin anti-B4-blocked ricin. Cancer Res. 1992 Aug 01; 52(15):4200-7.
View in: PubMed

Early signaling defects in human T cells anergized by T cell presentation of autoantigen. J Exp Med. 1992 Jul 01; 176(1):177-86.
View in: PubMed

Expression and function of the murine B7 antigen, the major costimulatory molecule expressed by peritoneal exudate cells. Proc Natl Acad Sci U S A. 1992 May 01; 89(9):4210-4.
View in: PubMed

Human bone marrow depleted of CD33-positive cells mediates delayed but durable reconstitution of hematopoiesis: clinical trial of MY9 monoclonal antibody-purged autografts for the treatment of acute myeloid leukemia. Blood. 1992 May 01; 79(9):2229-36.
View in: PubMed

Antibody and B7/BB1-mediated ligation of the CD28 receptor induces tyrosine phosphorylation in human T cells. J Exp Med. 1992 Apr 01; 175(4):951-60.
View in: PubMed

Growth arrest of human B lymphocytes is accompanied by induction of the low molecular weight mammalian heat shock protein (Hsp28). J Immunol. 1992 Mar 15; 148(6):1668-73.
View in: PubMed

The gene for B7, a costimulatory signal for T-cell activation, maps to chromosomal region 3q13.3-3q21. Blood. 1992 Jan 15; 79(2):489-94.
View in: PubMed

The central role of follicular dendritic cells in lymphoid tissues. Adv Immunol. 1992; 51:243-84.
View in: PubMed

Follicular non-Hodgkin's lymphoma cell adhesion to normal germinal centers and neoplastic follicles involves very late antigen-4 and vascular cell adhesion molecule-1. Blood. 1992 Jan 01; 79(1):206-12.
View in: PubMed

Murine B7 antigen provides an efficient costimulatory signal for activation of murine T lymphocytes via the T-cell receptor/CD3 complex. Proc Natl Acad Sci U S A. 1992 Jan 01; 89(1):271-5.
View in: PubMed

Immunotoxin therapy of malignancy. Important Adv Oncol. 1992; 111-35.
View in: PubMed

All advanced stage non-Hodgkin's lymphomas with a polymerase chain reaction amplifiable breakpoint of bcl-2 have residual cells containing the bcl-2 rearrangement at evaluation and after treatment. Blood. 1991 Dec 15; 78(12):3275-80.
View in: PubMed

An immunotoxin prepared with blocked ricin: a natural plant toxin adapted for therapeutic use. Cancer Res. 1991 Dec 01; 51(23 Pt 1):6236-42.
View in: PubMed

Hepatic dysfunction following T-cell-depleted allogeneic bone marrow transplantation. Transplantation. 1991 Dec; 52(6):1014-9.
View in: PubMed

Selective induction of B7/BB-1 on interferon-gamma stimulated monocytes: a potential mechanism for amplification of T cell activation through the CD28 pathway. Cell Immunol. 1991 Oct 15; 137(2):429-37.
View in: PubMed

Immunologic markers in non-Hodgkin's lymphoma. Hematol Oncol Clin North Am. 1991 Oct; 5(5):871-89.
View in: PubMed

Structure, expression, and T cell costimulatory activity of the murine homologue of the human B lymphocyte activation antigen B7. J Exp Med. 1991 Sep 01; 174(3):625-31.
View in: PubMed

B-cell surface antigen B7 provides a costimulatory signal that induces T cells to proliferate and secrete interleukin 2. Proc Natl Acad Sci U S A. 1991 Aug 01; 88(15):6575-9.
View in: PubMed

The impact of myeloid growth factors on engraftment following autologous bone marrow transplantation for malignant lymphoma. Semin Hematol. 1991 Apr; 28(2 Suppl 2):6-16.
View in: PubMed

Prophylaxis of bacterial infections with ciprofloxacin in patients undergoing bone marrow transplantation. Transplantation. 1991 Mar; 51(3):630-6.
View in: PubMed

Cellular interactions within the germinal centre. Res Immunol. 1991 Mar-Apr; 142(3):232-6.
View in: PubMed

Follicular dendritic cells contain a unique gene repertoire demonstrated by single-cell polymerase chain reaction. Blood. 1991 Feb 15; 77(4):787-91.
View in: PubMed

B-cell monoclonal antibodies and their use in clinical oncology. Cancer Invest. 1991; 9(1):69-84.
View in: PubMed

Gallium-67 imaging: a predictor of residual tumor viability and clinical outcome in patients with diffuse large-cell lymphoma. J Clin Oncol. 1990 Dec; 8(12):1966-70.
View in: PubMed

Acute and chronic pulmonary complications following autologous bone marrow transplantation in non-Hodgkin's lymphoma. Bone Marrow Transplant. 1990 Nov; 6(5):329-31.
View in: PubMed

Hepatic venoocclusive disease in autologous bone marrow transplantation of solid tumors and lymphomas. J Clin Oncol. 1990 Oct; 8(10):1699-706.
View in: PubMed

Adhesion of human B cells to germinal centers in vitro involves VLA-4 and INCAM-110. Science. 1990 Aug 31; 249(4972):1030-3.
View in: PubMed

Association between clonogenic cell growth and clinical risk group in B-cell chronic lymphocytic leukemia. Blood. 1990 Jul 01; 76(1):142-9.
View in: PubMed

T-cell-depleted autologous bone marrow transplantation therapy: analysis of immune deficiency and late complications. Blood. 1990 Jul 01; 76(1):235-44.
View in: PubMed

mAb 104, a new monoclonal antibody, recognizes the B7 antigen that is expressed on activated B cells and HTLV-1-transformed T cells. Immunology. 1990 Apr; 69(4):531-5.
View in: PubMed

The relationship of chronic lymphocytic leukemia to normal activated B cells. Leuk Lymphoma. 1990; 1(5-6):293-300.
View in: PubMed

Natural history of mixed chimerism after bone marrow transplantation with CD6-depleted allogeneic marrow: a stable equilibrium. Blood. 1990 Jan 01; 75(1):296-304.
View in: PubMed

Activation primes human B lymphocytes to respond to heat shock. J Exp Med. 1989 Nov 01; 170(5):1763-8.
View in: PubMed

B7, a new member of the Ig superfamily with unique expression on activated and neoplastic B cells. J Immunol. 1989 Oct 15; 143(8):2714-22.
View in: PubMed

Immunophenotypic profile of CNS lymphoma: a review of eighteen cases. J Neurooncol. 1989 Sep; 7(3):249-54.
View in: PubMed

Autologous bone-marrow transplantation in non-Hodgkin's lymphomas. Biochim Biophys Acta. 1989 Jul 28; 989(1):11-24.
View in: PubMed

Isolated human follicular dendritic cells display a unique antigenic phenotype. J Exp Med. 1989 Jun 01; 169(6):2043-58.
View in: PubMed

Expression and regulation of CD5 on in vitro activated human B cells. Eur J Immunol. 1989 May; 19(5):849-55.
View in: PubMed

Mechanism of graft failure in HLA-matched and HLA-mismatched bone marrow transplant recipients. Bone Marrow Transplant. 1989 May; 4(3):239-45.
View in: PubMed

Interleukin 6 gene expression in normal and neoplastic B cells. J Clin Invest. 1989 May; 83(5):1512-8.
View in: PubMed

Autologous bone marrow transplantation therapy for multiple myeloma. Eur J Haematol Suppl. 1989; 51:157-63.
View in: PubMed

Studies of in vitro activated CD5+ B cells. Blood. 1989 Jan; 73(1):202-8.
View in: PubMed

Pre-exposure of human B cells to recombinant IL-1 enhances subsequent proliferation. J Immunol. 1988 Nov 15; 141(10):3398-404.
View in: PubMed

Autologous bone marrow transplantation in the treatment of malignant lymphoma and Hodgkin's disease. Semin Hematol. 1988 Apr; 25(2 Suppl 2):58-65.
View in: PubMed

Autologous bone marrow transplantation in acute leukemia and lymphoma following ex vivo treatment with monoclonal antibodies and complement. Cancer Treat Res. 1988; 38:265-83.
View in: PubMed

B7, a B-cell-restricted antigen that identifies preactivated B cells. J Immunol. 1987 Nov 15; 139(10):3260-7.
View in: PubMed

B cell development in chronic lymphocytic leukemia. Semin Hematol. 1987 Oct; 24(4):230-9.
View in: PubMed

Normal cellular counterparts of B cell chronic lymphocytic leukemia. Blood. 1987 Aug; 70(2):418-27.
View in: PubMed

Cell surface markers in hematologic malignancies. Semin Oncol. 1987 Jun; 14(2):193-212.
View in: PubMed

Preexposure of resting B cells to interferon-gamma enhances their proliferative response to subsequent activation signals. Cell Immunol. 1987 May; 106(2):355-65.
View in: PubMed

Undifferentiated leukemia of infancy with t(11:17) chromosomal rearrangement. Coexpressing myeloid and B cell restricted antigens. Cancer. 1987 Mar 15; 59(6):1143-9.
View in: PubMed

Hematologic engraftment and immune reconstitution posttransplantation with anti-B1 purged autologous bone marrow. Blood. 1987 Feb; 69(2):597-604.
View in: PubMed

Expression of B cell activation antigens on normal and malignant B cells. Leukemia. 1987 Jan; 1(1):9-15.
View in: PubMed

Monoclonal antibodies: their use in bone marrow transplantation. Prog Hematol. 1987; 15:137-81.
View in: PubMed

Use of radiolabeled monoclonal anti-B1 antibody for B lymphocyte imaging in rhesus monkeys. Int J Rad Appl Instrum B. 1987; 14(2):99-105.
View in: PubMed

Antibodies reactive with the B1 molecule inhibit cell cycle progression but not activation of human B lymphocytes. Eur J Immunol. 1986 Aug; 16(8):881-7.
View in: PubMed

HD39 (B3), a B lineage-restricted antigen whose cell surface expression is limited to resting and activated human B lymphocytes. J Immunol. 1986 Jun 15; 136(12):4470-9.
View in: PubMed

Dual fluorochrome analysis of human B lymphocytes: phenotypic examination of resting, anti-immunoglobulin stimulated, and in vivo activated B cells. J Immunol. 1986 May 15; 136(10):3612-8.
View in: PubMed

Studies of the in vitro activation and differentiation of human B lymphocytes. II. Optimization of activation by anti-immunoglobulin antibody bound to beads: analysis of the role of autocrine effects on B-cell proliferation and of T-cell help in B-cell differentiation. Cell Immunol. 1986 Apr 15; 99(1):228-40.
View in: PubMed

Elimination of clonogenic tumor cells from human bone marrow using a combination of monoclonal antibody:ricin A chain conjugates. Cancer Res. 1986 Mar; 46(3):1208-13.
View in: PubMed

Gene products of the HLA-D region in normal and malignant tissues of nonlymphoid origin. Hum Immunol. 1986 Feb; 15(2):220-33.
View in: PubMed

Bone marrow transplantation in the therapy of non-Hodgkin's lymphomas. Important Adv Oncol. 1986; 287-310.
View in: PubMed

Acute leukemia with mixed lymphoid and myeloid phenotype. Br J Haematol. 1986 Jan; 62(1):196-7.
View in: PubMed

Antigenic heterogeneity among Burkitt's lymphoma cells surviving treatment with monoclonal antibody and complement. Leuk Res. 1986; 10(1):35-42.
View in: PubMed

Orderly expression of B cell antigens during the in vitro differentiation of nonmalignant human pre-B cells. J Immunol. 1985 Sep; 135(3):1746-51.
View in: PubMed

The B cell surface molecule B1 is functionally linked with B cell activation and differentiation. J Immunol. 1985 Aug; 135(2):973-9.
View in: PubMed

Elimination of clonogenic Burkitt's lymphoma cells from human bone marrow using 4-hydroperoxycyclophosphamide in combination with monoclonal antibodies and complement. Blood. 1985 May; 65(5):1064-70.
View in: PubMed

BLAST-2 [EBVCS], an early cell surface marker of human B cell activation, is superinduced by Epstein Barr virus. J Immunol. 1985 May; 134(5):3007-12.
View in: PubMed

Structural and functional characterization of IL 2 receptors on activated human B cells. J Immunol. 1985 Apr; 134(4):2387-92.
View in: PubMed

B5, a new B cell-restricted activation antigen. J Immunol. 1985 Apr; 134(4):2228-35.
View in: PubMed

Hairy cell leukemia: a tumor of pre-plasma cells. Blood. 1985 Mar; 65(3):620-9.
View in: PubMed

Studies of in vitro activation and differentiation of human B lymphocytes. I. Phenotypic and functional characterization of the B cell population responding to anti-Ig antibody. J Immunol. 1985 Mar; 134(3):1516-23.
View in: PubMed

Immunologic heterogeneity of diffuse large cell lymphoma. Blood. 1985 Mar; 65(3):630-7.
View in: PubMed

Isolation and functional analysis of human B cell populations. I. Characterization of the B1+B2+ and B1+B2- subsets. J Immunol. 1985 Feb; 134(2):820-7.
View in: PubMed

Effects of monoclonal antibody and complement treatment of human marrow on hematopoiesis in continuous bone marrow culture. Cancer Res. 1985 Feb; 45(2):758-67.
View in: PubMed

Elimination of malignant clonogenic cells from human bone marrow using multiple monoclonal antibodies and complement. Cancer Res. 1985 Feb; 45(2):499-503.
View in: PubMed

Cellular distribution of a human I-A-like (DS/DC) antigen on normal and neoplastic lymphoid cells. Hum Immunol. 1985 Jan; 12(1):23-35.
View in: PubMed

Immunohistologic characterization of two malignant lymphomas of germinal center type (centroblastic/centrocytic and centrocytic) with monoclonal antibodies. Follicular and diffuse lymphomas of small-cleaved-cell type are related but distinct entities. Am J Pathol. 1984 Nov; 117(2):262-72.
View in: PubMed

Primary Kaposi's sarcoma of the lung in an immunocompetent 32-year-old heterosexual white man. Cancer. 1984 Oct 15; 54(8):1696-8.
View in: PubMed

Purification of common acute lymphoblastic leukemia antigen positive cells from normal human bone marrow. Blood. 1984 Sep; 64(3):662-6.
View in: PubMed

Anti-B1 monoclonal antibody and complement treatment in autologous bone-marrow transplantation for relapsed B-cell non-Hodgkin's lymphoma. Lancet. 1984 Aug 25; 2(8400):427-31.
View in: PubMed

Molecular localization of human class II MT2 and MT3 determinants. J Exp Med. 1984 Aug 01; 160(2):472-93.
View in: PubMed

B cell origin of non-T cell acute lymphoblastic leukemia. A model for discrete stages of neoplastic and normal pre-B cell differentiation. J Clin Invest. 1984 Aug; 74(2):332-40.
View in: PubMed

Expression of human B cell-associated antigens on leukemias and lymphomas: a model of human B cell differentiation. Blood. 1984 Jun; 63(6):1424-33.
View in: PubMed

A monoclonal antibody with reactivity restricted to normal and neoplastic plasma cells. J Immunol. 1984 Jun; 132(6):3172-9.
View in: PubMed

Discordant expression of human Ia-like antigens on hematopoietic progenitor cells. J Immunol. 1984 May; 132(5):2324-9.
View in: PubMed

Surface antigen changes during B-lymphocyte activation in primates. Cell Immunol. 1984 Mar; 84(1):163-70.
View in: PubMed

Clinical, pathologic and immunologic features of patients with non-Hodgkin's lymphoma in a leukemic phase. A retrospective analysis of 34 patients. Cancer. 1983 Oct 01; 52(7):1220-8.
View in: PubMed

Identification of the membrane receptor for the complement fragment C3d by means of a monoclonal antibody. J Exp Med. 1983 Oct 01; 158(4):1021-33.
View in: PubMed

Evidence for genetic restriction in the suppression of erythropoiesis by a unique subset of T lymphocytes in man. J Clin Invest. 1983 Aug; 72(2):694-706.
View in: PubMed

Isolation and characterization of human B lymphocyte enriched populations. I. Purification of B cells by immune rosette depletion. J Immunol Methods. 1983 Jul 29; 61(3):283-92.
View in: PubMed

B4, a human B lymphocyte-associated antigen expressed on normal, mitogen-activated, and malignant B lymphocytes. J Immunol. 1983 Jul; 131(1):244-50.
View in: PubMed

Ontogeny of human hematopoietic cells: analysis utilizing monoclonal antibodies. J Immunol. 1983 Jul; 131(1):232-7.
View in: PubMed

Antigens on human plasma cells identified by monoclonal antibodies. J Immunol. 1983 Mar; 130(3):1132-8.
View in: PubMed

Biological behavior of human breast carcinoma-associated antigens expressed during cellular proliferation. Cancer Res. 1983 Feb; 43(2):851-7.
View in: PubMed

Differentiation patterns in the blastic phase of chronic myeloid leukemia. Blood. 1983 Jan; 61(1):85-91.
View in: PubMed

Purification and characterization of fetal hematopoietic cells that express the common acute lymphoblastic leukemia antigen (CALLA). J Exp Med. 1983 Jan 01; 157(1):114-29.
View in: PubMed

Further biochemical studies of the human B-cell differentiation antigens B1 and B2. Hybridoma. 1983; 2(1):17-28.
View in: PubMed

Alpha and beta chains of SB and DR antigens are structurally distinct. J Exp Med. 1982 Nov 01; 156(5):1557-62.
View in: PubMed

Epstein-Barr virus superinduces a new human B cell differentiation antigen (B-LAST 1) expressed on transformed lymphoblasts. Cell. 1982 Sep; 30(2):415-25.
View in: PubMed

Serologic identification of the human secondary B cell antigens. Correlations between function, genetics, and structure. J Exp Med. 1982 Sep 01; 156(3):731-43.
View in: PubMed

Induction of human B cell antigens in non-T cell acute lymphoblastic leukemia. J Clin Invest. 1982 Aug; 70(2):433-42.
View in: PubMed

T-cell lymphoblastic lymphoma with subsequent acute nonlymphocytic leukemia: a case report. Cancer. 1982 Jul 01; 50(1):118-24.
View in: PubMed

Comparison in T- and B-cell markers in patients with Sjögren's syndrome and systemic lupus erythematosus. Clin Immunol Immunopathol. 1982 Feb; 22(2):270-8.
View in: PubMed

The biology of SAA: identification of the inducer, in vitro synthesis, and heterogeneity demonstrated with monoclonal antibodies. Ann N Y Acad Sci. 1982; 389:126-36.
View in: PubMed

Reactivity of a monoclonal antibody with human ovarian carcinoma. J Clin Invest. 1981 Nov; 68(5):1331-7.
View in: PubMed

Expression of myeloid differentiation antigens on normal and malignant myeloid cells. J Clin Invest. 1981 Oct; 68(4):932-41.
View in: PubMed

Expression of a 26,000-dalton glycoprotein on activated human T cells. Cell Immunol. 1981 Oct; 64(1):192-9.
View in: PubMed

Stages of B cell differentiation in human lymphoid tissue. J Exp Med. 1981 Sep 01; 154(3):737-49.
View in: PubMed

Lymphoid subpopulations of peripheral blood and spleen in untreated Hodgkin's disease. Cancer. 1981 Sep 01; 48(5):1170-6.
View in: PubMed

Expression of common acute lymphoblastic leukemia antigen (CALLA) by lymphomas of B-cell and T-cell lineage. Blood. 1981 Sep; 58(3):648-52.
View in: PubMed

Human cell lines express multiple populations of Ia-like molecules. Hum Immunol. 1981 Aug; 3(1):67-76.
View in: PubMed

Cell surface characterization of malignant T cells from lymphoblastic lymphoma using monoclonal antibodies: evidence for phenotypic differences between malignant T cells from patients with acute lymphoblastic leukemia and lymphoblastic lymphoma. Blood. 1981 Jun; 57(6):1105-10.
View in: PubMed

Expression of cell surface markers after human B lymphocyte activation. Proc Natl Acad Sci U S A. 1981 Jun; 78(6):3848-52.
View in: PubMed

Characterization of a human B cell-specific antigen (B2) distinct from B1. J Immunol. 1981 May; 126(5):1941-7.
View in: PubMed

Monoclonal antibody identifies a new Ia-like (p29,34) polymorphic system linked to the HLA-D/DR region. Nature. 1981 Apr 16; 290(5807):591-3.
View in: PubMed

Antigens on human monocytes identified by monoclonal antibodies. J Immunol. 1981 Apr; 126(4):1435-42.
View in: PubMed

Surface antigens on malignant Sézary and T-CLL cells correspond to those of mature T cells. Blood. 1981 Mar; 57(3):526-30.
View in: PubMed

Monoclonal antibodies defining serologically distinct HLA-D/DR related Ia-like antigens in man. Hum Immunol. 1981 Feb; 2(1):77-90.
View in: PubMed

A unique cell surface antigen identifying lymphoid malignancies of B cell origin. J Clin Invest. 1981 Jan; 67(1):134-40.
View in: PubMed

Diagnosis and treatment of human leukemias and lymphomas utilizing monoclonal antibodies. Prog Hematol. 1981; 12:187-225.
View in: PubMed

Expression of normal monocyte-macrophage differentiation antigens on HL60 promyelocytes undergoing differentiation induced by leukocyte-conditioned medium or phorbol diester. Leuk Res. 1981; 5(6):491-5.
View in: PubMed

Characterization of a human B lymphocyte-specific antigen. J Immunol. 1980 Oct; 125(4):1678-85.
View in: PubMed

Serotherapy of a patient with a monoclonal antibody directed against a human lymphoma-associated antigen. Cancer Res. 1980 Sep; 40(9):3147-54.
View in: PubMed

A monoclonal antibody defining a lymphoma-associated antigen in man. J Immunol. 1980 Aug; 125(2):570-7.
View in: PubMed

Heterogeneity of T-cell lymphoblastic malignancies. Blood. 1980 May; 55(5):806-10.
View in: PubMed

The T lymphoblastic malignancies. Cancer Chemother Pharmacol. 1980; 4(1):11-5.
View in: PubMed

alpha-Naphthyl acetate esterase activity--a cytochemical marker for T lymphocytees. Correlation with immunologic studies of normal tissues, lymphocytic leukemias, non-Hodgkin's lymphomas, Hodgkin's disease, and other lymphoproliferative disorders. Am J Pathol. 1979 Oct; 97(1):17-41.
View in: PubMed

Subset derivation of T-cell acute lymphoblastic leukemia in man. J Clin Invest. 1979 Aug; 64(2):392-7.
View in: PubMed

T-cell-subset characterization of human T-CLL. Blood. 1979 Jun; 53(6):1066-75.
View in: PubMed

Regulatory mechanisms in cell-mediated immune responses. III. Antigen-specific and nonspecific suppressor activities generated during MLC. J Immunol. 1977 Sep; 119(3):961-7.
View in: PubMed

Regulatory mechanisms in cell-mediated immune responses. II. Comparison of culture-induced and alloantigen-induced suppressor cells in MLR and CML. J Immunol. 1977 May; 118(5):1886-95.
View in: PubMed

Survival after massive procainamide ingestion. Am J Cardiol. 1973 Oct; 32(5):727-30.
View in: PubMed

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