Martin E. Hemler, PhD

Martin E. Hemler, PhD

Researcher

Contact Information

Office Phone Number

(617) 632-3410

Fax

(617) 632-2662

Biography

Martin E. Hemler, PhD

Dr. Hemler received his PhD in biological chemistry from the University of Michigan in 1978. After postdoctoral research at DFCI from 1979 to 1984, he received a faculty appointment at DFCI and was promoted to professor in 1994. He is exclusively involved in basic laboratory research, focusing on cell surface molecules that participate in cell adhesion, migration, and invasion.

Researcher

Physician

Principal Investigator, Cancer Immunology and Virology, Dana-Farber Cancer Institute
Professor of Pathology, Brigham and Women’s Hospital

Research

    Novel adhesion and palmitoylation mechanisms that regulate the tumor microenvironment

    Cell adhesion is a basic process in cell biology, controlling cell growth, death, differentiation, movement, and tissue organization in normal cells, as well as the proliferation and metastasis of tumor cells. The Hemler Lab focuses on the molecular basis for cell adhesion and migration. In particular, they are interested in the structures and functions of heterodimers in the INTEGRIN family, including studies of the mechanisms whereby integrin functions are rapidly turned on and off, and different integrins link to distinct cellular signaling pathways. In addition, they study other cell surface transmembrane proteins that associate with integrins. Recent studies have shown that transmembrane linker proteins, called tetraspanin proteins, allow the membrane proximal extracellular domains of integrins to play key roles in the recruitment of intracellular signaling enzymes such as protein kinase C, and phosphatidylinositol 4-kinase.

    Recent studies have focused on how certain integrins may be linked to regulation of matrix metalloproteinase (MMP) production, a key process during cell and tissue remodeling and tumor cell metastasis. Most recently, they have generated mutant mice in which the tetraspanin CD151 gene has been deleted to investigate the role of CD151 during tumor progression.

    Research Departments

    Publications

      • Antioxidant and Anticancer Functions of Protein Acyltransferase DHHC3. Antioxidants (Basel). 2022 May 12; 11(5). View in: Pubmed

      • Antioxidant functions of DHHC3 suppress anti-cancer drug activities. Cell Mol Life Sci. 2021 Mar; 78(5):2341-2353. View in: Pubmed

      • Integrin-independent support of cancer drug resistance by tetraspanin CD151. Cell Mol Life Sci. 2019 Apr; 76(8):1595-1604. View in: Pubmed

      • Multiple pro-tumor roles for protein acyltransferase DHHC3. Oncoscience. 2017 Nov; 4(11-12):152-153. View in: Pubmed

      • Protein Acyltransferase DHHC3 Regulates Breast Tumor Growth, Oxidative Stress, and Senescence. Cancer Res. 2017 12 15; 77(24):6880-6890. View in: Pubmed

      • Novel impact of EWI-2, CD9, and CD81 on TGF-ß signaling in melanoma. Mol Cell Oncol. 2015 Oct 02; 2(1). View in: Pubmed

      • EWI-2 negatively regulates TGF-ß signaling leading to altered melanoma growth and metastasis. Cell Res. 2015 Mar; 25(3):370-85. View in: Pubmed

      • Tetraspanin proteins promote multiple cancer stages. Nat Rev Cancer. 2014 Jan; 14(1):49-60. View in: Pubmed

      • Tetraspanin proteins promote multiple cancer stages. Nat Rev Cancer. 2013 Dec 23; 14(1):49-60. View in: Pubmed

      • Tetraspanin TSPAN12 regulates tumor growth and metastasis and inhibits ß-catenin degradation. Cell Mol Life Sci. 2014 Apr; 71(7):1305-14. View in: Pubmed

      • Renal disease appears not to affect carcinogenesis in CD151-null mice. Oncogene. 2013 Sep 12; 32(37):4458. View in: Pubmed

      • Integrin-associated CD151 drives ErbB2-evoked mammary tumor onset and metastasis. Neoplasia. 2012 Aug; 14(8):678-89. View in: Pubmed

      • Tetraspanin CD151 plays a key role in skin squamous cell carcinoma. Oncogene. 2013 Apr 04; 32(14):1772-83. View in: Pubmed

      • Palmitoylation by DHHC3 is critical for the function, expression, and stability of integrin a6ß4. Cell Mol Life Sci. 2012 Jul; 69(13):2233-44. View in: Pubmed

      • Tetraspanin CD151 protects against pulmonary fibrosis by maintaining epithelial integrity. Am J Respir Crit Care Med. 2012 Jul 15; 186(2):170-80. View in: Pubmed

      • Transcriptional profiling of stroma from inflamed and resting lymph nodes defines immunological hallmarks. Nat Immunol. 2012 Apr 01; 13(5):499-510. View in: Pubmed

      • CD151 restricts the a6 integrin diffusion mode. J Cell Sci. 2012 Mar 15; 125(Pt 6):1478-87. View in: Pubmed

      • The C-terminal tail of tetraspanin protein CD9 contributes to its function and molecular organization. J Cell Sci. 2011 Aug 15; 124(Pt 16):2702-10. View in: Pubmed

      • Diminished metastasis in tetraspanin CD151-knockout mice. Blood. 2011 Jul 14; 118(2):464-72. View in: Pubmed

      • Tetraspanin protein contributions to cancer. Biochem Soc Trans. 2011 Apr; 39(2):547-52. View in: Pubmed

      • Disruption of laminin-integrin-CD151-focal adhesion kinase axis sensitizes breast cancer cells to ErbB2 antagonists. Cancer Res. 2010 Mar 15; 70(6):2256-63. View in: Pubmed

      • Tetraspanin12 regulates ADAM10-dependent cleavage of amyloid precursor protein. FASEB J. 2009 Nov; 23(11):3674-81. View in: Pubmed

      • Tetraspanin proteins regulate membrane type-1 matrix metalloproteinase-dependent pericellular proteolysis. Mol Biol Cell. 2009 Apr; 20(7):2030-40. View in: Pubmed

      • Glioblastoma inhibition by cell surface immunoglobulin protein EWI-2, in vitro and in vivo. Neoplasia. 2009 Jan; 11(1):77-86, 4p following 86. View in: Pubmed

      • Overexpression of fatty acid synthase is associated with palmitoylation of Wnt1 and cytoplasmic stabilization of beta-catenin in prostate cancer. Lab Invest. 2008 Dec; 88(12):1340-8. View in: Pubmed

      • Targeting of tetraspanin proteins--potential benefits and strategies. Nat Rev Drug Discov. 2008 Sep; 7(9):747-58. View in: Pubmed

      • DHHC2 affects palmitoylation, stability, and functions of tetraspanins CD9 and CD151. Mol Biol Cell. 2008 Aug; 19(8):3415-25. View in: Pubmed

      • CD151 accelerates breast cancer by regulating alpha 6 integrin function, signaling, and molecular organization. Cancer Res. 2008 May 01; 68(9):3204-13. View in: Pubmed

      • A novel cysteine cross-linking method reveals a direct association between claudin-1 and tetraspanin CD9. Mol Cell Proteomics. 2007 Nov; 6(11):1855-67. View in: Pubmed

      • Deletion of tetraspanin Cd151 results in decreased pathologic angiogenesis in vivo and in vitro. Blood. 2007 Feb 15; 109(4):1524-32. View in: Pubmed

      • In vitro interaction between hepatitis C virus (HCV) envelope glycoprotein E2 and serum lipoproteins (LPs) results in enhanced cellular binding of both HCV E2 and LPs. J Infect Dis. 2006 Oct 15; 194(8):1058-67. View in: Pubmed

      • EWI-2 and EWI-F link the tetraspanin web to the actin cytoskeleton through their direct association with ezrin-radixin-moesin proteins. J Biol Chem. 2006 Jul 14; 281(28):19665-75. View in: Pubmed

      • Contrasting effects of EWI proteins, integrins, and protein palmitoylation on cell surface CD9 organization. J Biol Chem. 2006 May 05; 281(18):12976-85. View in: Pubmed

      • Tetraspanin functions and associated microdomains. Nat Rev Mol Cell Biol. 2005 Oct; 6(10):801-11. View in: Pubmed

      • Structural organization and interactions of transmembrane domains in tetraspanin proteins. BMC Struct Biol. 2005 Jun 28; 5:11. View in: Pubmed

      • Metabolic activation-related CD147-CD98 complex. Mol Cell Proteomics. 2005 Aug; 4(8):1061-71. View in: Pubmed

      • Palmitoylation supports assembly and function of integrin-tetraspanin complexes. J Cell Biol. 2004 Dec 20; 167(6):1231-40. View in: Pubmed

      • Links between CD147 function, glycosylation, and caveolin-1. Mol Biol Cell. 2004 Sep; 15(9):4043-50. View in: Pubmed

      • Dynamic regulation of a GPCR-tetraspanin-G protein complex on intact cells: central role of CD81 in facilitating GPR56-Galpha q/11 association. Mol Biol Cell. 2004 May; 15(5):2375-87. View in: Pubmed

      • Evidence for specific tetraspanin homodimers: inhibition of palmitoylation makes cysteine residues available for cross-linking. Biochem J. 2004 Jan 15; 377(Pt 2):407-17. View in: Pubmed

      • Caveolin-1 regulates matrix metalloproteinases-1 induction and CD147/EMMPRIN cell surface clustering. J Biol Chem. 2004 Mar 19; 279(12):11112-8. View in: Pubmed

      • EWI-2 modulates lymphocyte integrin alpha4beta1 functions. Blood. 2004 Apr 15; 103(8):3013-9. View in: Pubmed

      • EWI-2 regulates alpha3beta1 integrin-dependent cell functions on laminin-5. J Cell Biol. 2003 Dec 08; 163(5):1167-77. View in: Pubmed

      • Tetraspanin CD151 regulates alpha6beta1 integrin adhesion strengthening. Proc Natl Acad Sci U S A. 2003 Jun 24; 100(13):7616-21. View in: Pubmed

      • Functional domains in tetraspanin proteins. Trends Biochem Sci. 2003 Feb; 28(2):106-12. View in: Pubmed

      • Tetraspanin proteins mediate cellular penetration, invasion, and fusion events and define a novel type of membrane microdomain. Annu Rev Cell Dev Biol. 2003; 19:397-422. View in: Pubmed

      • An extracellular site on tetraspanin CD151 determines alpha 3 and alpha 6 integrin-dependent cellular morphology. J Cell Biol. 2002 Sep 30; 158(7):1299-309. View in: Pubmed

      • Palmitoylation of tetraspanin proteins: modulation of CD151 lateral interactions, subcellular distribution, and integrin-dependent cell morphology. Mol Biol Cell. 2002 Mar; 13(3):767-81. View in: Pubmed

      • Function of the tetraspanin CD151-alpha6beta1 integrin complex during cellular morphogenesis. Mol Biol Cell. 2002 Jan; 13(1):1-11. View in: Pubmed

      • Specific tetraspanin functions. J Cell Biol. 2001 Dec 24; 155(7):1103-7. View in: Pubmed

      • Retooling of the beta 4 integrin in tumor cells--ligands lost and kinase gained. Dev Cell. 2001 Dec; 1(6):728-30. View in: Pubmed

      • Beta1 integrins show specific association with CD98 protein in low density membranes. BMC Biochem. 2001; 2:10. View in: Pubmed

      • EWI-2 is a major CD9 and CD81 partner and member of a novel Ig protein subfamily. J Biol Chem. 2001 Nov 02; 276(44):40545-54. View in: Pubmed

      • Transmembrane-4 superfamily proteins associate with activated protein kinase C (PKC) and link PKC to specific beta(1) integrins. J Biol Chem. 2001 Jul 06; 276(27):25005-13. View in: Pubmed

      • Regulation of MMP-1 and MMP-2 production through CD147/extracellular matrix metalloproteinase inducer interactions. Cancer Res. 2001 Mar 01; 61(5):2276-81. View in: Pubmed

      • Phosphorylation of a conserved integrin alpha 3 QPSXXE motif regulates signaling, motility, and cytoskeletal engagement. Mol Biol Cell. 2001 Feb; 12(2):351-65. View in: Pubmed

      • Evaluation of prototype transmembrane 4 superfamily protein complexes and their relation to lipid rafts. J Biol Chem. 2001 Mar 16; 276(11):7974-84. View in: Pubmed

      • FPRP, a major, highly stoichiometric, highly specific CD81- and CD9-associated protein. J Biol Chem. 2001 Feb 16; 276(7):4853-62. View in: Pubmed

      • Specific interactions among transmembrane 4 superfamily (TM4SF) proteins and phosphoinositide 4-kinase. Biochem J. 2000 Nov 01; 351 Pt 3:629-37. View in: Pubmed

      • Cell-to-cell contact and extracellular matrix. Editorial overview Curr Opin Cell Biol. 2000 Oct; 12(5):539-41. View in: Pubmed

      • Transmembrane-4-superfamily proteins CD151 and CD81 associate with alpha 3 beta 1 integrin, and selectively contribute to alpha 3 beta 1-dependent neurite outgrowth. J Cell Sci. 2000 Jun; 113 ( Pt 11):1871-82. View in: Pubmed

      • Direct extracellular contact between integrin alpha(3)beta(1) and TM4SF protein CD151. J Biol Chem. 2000 Mar 31; 275(13):9230-8. View in: Pubmed

      • Role of transmembrane 4 superfamily (TM4SF) proteins CD9 and CD81 in muscle cell fusion and myotube maintenance. J Cell Biol. 1999 Aug 23; 146(4):893-904. View in: Pubmed

      • Trio amino-terminal guanine nucleotide exchange factor domain expression promotes actin cytoskeleton reorganization, cell migration and anchorage-independent cell growth. J Cell Sci. 1999 Jun; 112 ( Pt 12):1825-34. View in: Pubmed

      • Dystroglycan versatility. Cell. 1999 May 28; 97(5):543-6. View in: Pubmed

      • Interaction of the integrin beta1 cytoplasmic domain with ICAP-1 protein. J Biol Chem. 1999 Jan 01; 274(1):11-9. View in: Pubmed

      • The light chain of CD98 is identified as E16/TA1 protein. J Biol Chem. 1998 Dec 11; 273(50):33127-9. View in: Pubmed

      • Highly stoichiometric, stable, and specific association of integrin alpha3beta1 with CD151 provides a major link to phosphatidylinositol 4-kinase, and may regulate cell migration. Mol Biol Cell. 1998 Oct; 9(10):2751-65. View in: Pubmed

      • Beta1 integrin cytoplasmic domain regulates the constitutive conformation detected by MAb 15/7, but not the ligand-induced conformation. J Cell Biochem. 1998 Oct 01; 71(1):63-73. View in: Pubmed

      • Integrin associated proteins. Curr Opin Cell Biol. 1998 Oct; 10(5):578-85. View in: Pubmed

      • Recombinant soluble human alpha 3 beta 1 integrin: purification, processing, regulation, and specific binding to laminin-5 and invasin in a mutually exclusive manner. Biochemistry. 1998 Aug 04; 37(31):10945-55. View in: Pubmed

      • Divalent cations and ligands induce conformational changes that are highly divergent among beta1 integrins. J Biol Chem. 1998 Mar 20; 273(12):6670-8. View in: Pubmed

      • Are changes in integrin affinity and conformation overemphasized? Trends Biochem Sci. 1998 Jan; 23(1):30-4. View in: Pubmed

      • Defining extracellular integrin alpha-chain sites that affect cell adhesion and adhesion strengthening without altering soluble ligand binding. Mol Biol Cell. 1997 Dec; 8(12):2647-57. View in: Pubmed

      • NAG-2, a novel transmembrane-4 superfamily (TM4SF) protein that complexes with integrins and other TM4SF proteins. J Biol Chem. 1997 Nov 14; 272(46):29181-9. View in: Pubmed

      • Generation of monoclonal antibodies to integrin-associated proteins. Evidence that alpha3beta1 complexes with EMMPRIN/basigin/OX47/M6. J Biol Chem. 1997 Nov 14; 272(46):29174-80. View in: Pubmed

      • Mutational evidence for control of cell adhesion through integrin diffusion/clustering, independent of ligand binding. J Exp Med. 1997 Oct 20; 186(8):1347-55. View in: Pubmed

      • A novel link between integrins, transmembrane-4 superfamily proteins (CD63 and CD81), and phosphatidylinositol 4-kinase. J Biol Chem. 1997 Jan 31; 272(5):2595-8. View in: Pubmed

      • Integrin alpha chain cytoplasmic tails regulate "antibody-redirected" cell adhesion, independently of ligand binding. Eur J Immunol. 1997 Jan; 27(1):78-84. View in: Pubmed

      • Transmembrane-4 superfamily proteins CD81 (TAPA-1), CD82, CD63, and CD53 specifically associated with integrin alpha 4 beta 1 (CD49d/CD29). J Immunol. 1996 Sep 01; 157(5):2039-47. View in: Pubmed

      • Intracellular single-chain antibody inhibits integrin VLA-4 maturation and function. Biochem J. 1996 Sep 01; 318 ( Pt 2):591-6. View in: Pubmed

      • Bcr/Abl expression stimulates integrin function in hematopoietic cell lines. J Clin Invest. 1996 Jul 15; 98(2):521-8. View in: Pubmed

      • Reduction of tumorigenicity by alpha 3 integrin in a rhabdomyosarcoma cell line. Cell Adhes Commun. 1996 Jul; 4(1):41-52. View in: Pubmed

      • Association of TM4SF proteins with integrins: relevance to cancer. Biochim Biophys Acta. 1996 Jun 07; 1287(2-3):67-71. View in: Pubmed

      • Characterization of novel complexes on the cell surface between integrins and proteins with 4 transmembrane domains (TM4 proteins). Mol Biol Cell. 1996 Feb; 7(2):193-207. View in: Pubmed

      • Integrin alpha 4 cysteines 278 and 717 modulate VLA-4 ligand binding and also contribute to alpha 4/180 formation. Biochem J. 1996 Feb 01; 313 ( Pt 3):899-908. View in: Pubmed

      • Investigation of the role of beta 1 integrins in cell-cell adhesion. J Cell Sci. 1995 Nov; 108 ( Pt 11):3635-44. View in: Pubmed

      • Monoclonal antibody 9EG7 defines a novel beta 1 integrin epitope induced by soluble ligand and manganese, but inhibited by calcium. J Biol Chem. 1995 Oct 27; 270(43):25570-7. View in: Pubmed

      • Specific association of CD63 with the VLA-3 and VLA-6 integrins. J Biol Chem. 1995 Jul 28; 270(30):17784-90. View in: Pubmed

      • Molecular mapping of functional antibody binding sites of alpha 4 integrin. J Biol Chem. 1995 Jun 16; 270(24):14270-3. View in: Pubmed

      • Specialized functional properties of the integrin alpha 4 cytoplasmic domain. Mol Biol Cell. 1995 Jun; 6(6):661-74. View in: Pubmed

      • Integrin-ligand binding. Do integrins use a 'MIDAS touch' to grasp an Asp? Curr Biol. 1995 Jun 01; 5(6):615-7. View in: Pubmed

      • The integrin VLA-4 supports tethering and rolling in flow on VCAM-1. J Cell Biol. 1995 Mar; 128(6):1243-53. View in: Pubmed

      • Integrin-mediated collagen matrix reorganization by cultured human vascular smooth muscle cells. Circ Res. 1995 Feb; 76(2):209-14. View in: Pubmed

      • The leukocyte beta 1 integrins. Curr Opin Hematol. 1995 Jan; 2(1):61-7. View in: Pubmed

      • The pathophysiologic role of alpha 4 integrins in vivo. J Clin Invest. 1994 Nov; 94(5):1722-8. View in: Pubmed

      • The I domain is essential for echovirus 1 interaction with VLA-2. Cell Adhes Commun. 1994 Oct; 2(5):455-64. View in: Pubmed

      • Integrin alpha 2 cytoplasmic domain deletion effects: loss of adhesive activity parallels ligand-independent recruitment into focal adhesions. Mol Biol Cell. 1994 Sep; 5(9):977-88. View in: Pubmed

      • Minimum alpha chain cytoplasmic tail sequence needed to support integrin-mediated adhesion. J Biol Chem. 1994 Aug 05; 269(31):19859-67. View in: Pubmed

      • Proteolytic cleavage of the integrin beta 4 subunit. Exp Cell Res. 1994 May; 212(1):2-9. View in: Pubmed

      • Contrasting roles for integrin beta 1 and beta 5 cytoplasmic domains in subcellular localization, cell proliferation, and cell migration. J Cell Biol. 1994 Apr; 125(2):447-60. View in: Pubmed

      • Mutation of putative divalent cation sites in the alpha 4 subunit of the integrin VLA-4: distinct effects on adhesion to CS1/fibronectin, VCAM-1, and invasin. J Cell Biol. 1993 Oct; 123(1):245-53. View in: Pubmed

      • Role of the alpha subunit cytoplasmic domain in regulation of adhesive activity mediated by the integrin VLA-2. J Biol Chem. 1993 Aug 05; 268(22):16279-85. View in: Pubmed

      • Adhesion molecules: cellular recognition mechanisms. The Pezcoller Foundation Symposia, Rovereto, June 24-26, 1992. Ann Oncol. 1993 Aug; 4(7):545-7. View in: Pubmed

      • Interchangeable alpha chain cytoplasmic domains play a positive role in control of cell adhesion mediated by VLA-4, a beta 1 integrin. J Exp Med. 1993 Aug 01; 178(2):649-60. View in: Pubmed

      • The integrin VLA-2 binds echovirus 1 and extracellular matrix ligands by different mechanisms. J Clin Invest. 1993 Jul; 92(1):232-9. View in: Pubmed

      • A study of the structure, function and distribution of beta 5 integrins using novel anti-beta 5 monoclonal antibodies. J Cell Sci. 1993 May; 105 ( Pt 1):101-11. View in: Pubmed

      • Fourth annual Pezcoller Symposium--adhesion molecules: cellular recognition mechanisms. Cancer Res. 1993 May 01; 53(9):2192-4. View in: Pubmed

      • The function and distinctive regulation of the integrin VLA-3 in cell adhesion, spreading, and homotypic cell aggregation. J Biol Chem. 1993 Apr 25; 268(12):8651-7. View in: Pubmed

      • Alpha 4/180, a novel form of the integrin alpha 4 subunit. J Biol Chem. 1993 Apr 05; 268(10):7028-35. View in: Pubmed

      • Multiple activation states of VLA-4. Mechanistic differences between adhesion to CS1/fibronectin and to vascular cell adhesion molecule-1. J Biol Chem. 1993 Jan 05; 268(1):228-34. View in: Pubmed

      • Multiple functional forms of the integrin VLA-2 can be derived from a single alpha 2 cDNA clone: interconversion of forms induced by an anti-beta 1 antibody. J Cell Biol. 1993 Jan; 120(2):537-43. View in: Pubmed

      • Functional role of alpha 2/beta 1 and alpha 4/beta 1 integrins in leukocyte intercellular adhesion induced through the common beta 1 subunit. Eur J Immunol. 1992 Dec; 22(12):3111-9. View in: Pubmed

      • Role of beta 1 and beta 2 integrins in the adhesion of human CD34hi stem cells to bone marrow stroma. J Clin Invest. 1992 Aug; 90(2):358-67. View in: Pubmed

      • Adhesion to vascular cell adhesion molecule 1 and fibronectin. Comparison of alpha 4 beta 1 (VLA-4) and alpha 4 beta 7 on the human B cell line JY. J Biol Chem. 1992 Apr 25; 267(12):8366-70. View in: Pubmed

      • Identification of the integrin VLA-2 as a receptor for echovirus 1. Science. 1992 Mar 27; 255(5052):1718-20. View in: Pubmed

      • Distinct cellular functions mediated by different VLA integrin alpha subunit cytoplasmic domains. Cell. 1992 Mar 20; 68(6):1051-60. View in: Pubmed

      • Functional and structural analysis of VLA-4 integrin alpha 4 subunit cleavage. J Biol Chem. 1992 Jan 25; 267(3):1786-91. View in: Pubmed

      • Analyses of VLA-4 structure and function. Adv Exp Med Biol. 1992; 323:163-70. View in: Pubmed

      • Functional roles for integrin alpha subunit cytoplasmic domains. Cold Spring Harb Symp Quant Biol. 1992; 57:213-20. View in: Pubmed

      • Cloning and expression of cDNAs for the alpha subunit of the murine lymphocyte-Peyer's patch adhesion molecule. J Cell Biol. 1991 Nov; 115(4):1149-58. View in: Pubmed

      • Integrin alpha 2 beta 1 (VLA-2) mediates reorganization and contraction of collagen matrices by human cells. Cell. 1991 Oct 18; 67(2):403-10. View in: Pubmed

      • Molecular cloning and expression of the cDNA for alpha 3 subunit of human alpha 3 beta 1 (VLA-3), an integrin receptor for fibronectin, laminin, and collagen. J Cell Biol. 1991 Oct; 115(1):257-66. View in: Pubmed

      • T cell receptor-dependent, antigen-specific stimulation of a murine T cell clone induces a transient, VLA protein-mediated binding to extracellular matrix. J Immunol. 1991 Jul 15; 147(2):398-404. View in: Pubmed

      • Functional evidence for three distinct and independently inhibitable adhesion activities mediated by the human integrin VLA-4. Correlation with distinct alpha 4 epitopes. J Biol Chem. 1991 Jun 05; 266(16):10241-5. View in: Pubmed

      • In vitro and in vivo consequences of VLA-2 expression on rhabdomyosarcoma cells. Science. 1991 Mar 29; 251(5001):1600-2. View in: Pubmed

      • Receptor functions for the integrin VLA-3: fibronectin, collagen, and laminin binding are differentially influenced by Arg-Gly-Asp peptide and by divalent cations. J Cell Biol. 1991 Jan; 112(1):169-81. View in: Pubmed

      • Multiple ligand binding functions for VLA-2 (alpha 2 beta 1) and VLA-3 (alpha 3 beta 1) in the integrin family. Cell Differ Dev. 1990 Dec 02; 32(3):229-38. View in: Pubmed

      • Cloning, primary structure and properties of a novel human integrin beta subunit. EMBO J. 1990 May; 9(5):1561-8. View in: Pubmed

      • Structure of the integrin VLA-4 and its cell-cell and cell-matrix adhesion functions. Immunol Rev. 1990 Apr; 114:45-65. View in: Pubmed

      • VCAM-1 on activated endothelium interacts with the leukocyte integrin VLA-4 at a site distinct from the VLA-4/fibronectin binding site. Cell. 1990 Feb 23; 60(4):577-84. View in: Pubmed

      • VLA proteins in the integrin family: structures, functions, and their role on leukocytes. Annu Rev Immunol. 1990; 8:365-400. View in: Pubmed

      • The human integrin VLA-2 is a collagen receptor on some cells and a collagen/laminin receptor on others. Proc Natl Acad Sci U S A. 1989 Dec; 86(24):9906-10. View in: Pubmed

      • Analysis of the tumor-associated antigen TSP-180. Identity with alpha 6-beta 4 in the integrin superfamily. J Biol Chem. 1989 Sep 15; 264(26):15515-21. View in: Pubmed

      • A novel monoclonal antibody, 1B3.1, binds to a new epitope of the VLA-1 molecule. Cell Immunol. 1989 Sep; 122(2):416-23. View in: Pubmed

      • The primary structure of the VLA-2/collagen receptor alpha 2 subunit (platelet GPIa): homology to other integrins and the presence of a possible collagen-binding domain. J Cell Biol. 1989 Jul; 109(1):397-407. View in: Pubmed

      • The primary structure of the alpha 4 subunit of VLA-4: homology to other integrins and a possible cell-cell adhesion function. EMBO J. 1989 May; 8(5):1361-8. View in: Pubmed

      • Association of the VLA alpha 6 subunit with a novel protein. A possible alternative to the common VLA beta 1 subunit on certain cell lines. J Biol Chem. 1989 Apr 15; 264(11):6529-35. View in: Pubmed

      • Regulation of cell adhesion receptors by transforming growth factor-beta. Concomitant regulation of integrins that share a common beta 1 subunit. J Biol Chem. 1989 Jan 05; 264(1):380-8. View in: Pubmed

      • Extracellular matrix receptors, ECMRII and ECMRI, for collagen and fibronectin correspond to VLA-2 and VLA-3 in the VLA family of heterodimers. J Cell Biochem. 1988 Aug; 37(4):385-93. View in: Pubmed

      • Regulation of proteins in the VLA cell substrate adhesion family: influence of cell growth conditions on VLA-1, VLA-2, and VLA-3 expression. Exp Cell Res. 1988 Jul; 177(1):132-42. View in: Pubmed

      • Multiple very late antigen (VLA) heterodimers on platelets. Evidence for distinct VLA-2, VLA-5 (fibronectin receptor), and VLA-6 structures. J Biol Chem. 1988 Jun 05; 263(16):7660-5. View in: Pubmed

      • Adhesive protein receptors on hematopoietic cells. Immunol Today. 1988 Apr; 9(4):109-13. View in: Pubmed

      • T lymphocytes compartmentalized on the epithelial surface of the lower respiratory tract express the very late activation antigen complex VLA-1. Clin Immunol Immunopathol. 1988 Feb; 46(2):221-33. View in: Pubmed

      • Characterization of the cell surface heterodimer VLA-4 and related peptides. J Biol Chem. 1987 Aug 25; 262(24):11478-85. View in: Pubmed

      • The very late antigen family of heterodimers is part of a superfamily of molecules involved in adhesion and embryogenesis. Proc Natl Acad Sci U S A. 1987 May; 84(10):3239-43. View in: Pubmed

      • Cell matrix adhesion-related proteins VLA-1 and VLA-2: regulation of expression on T cells. J Immunol. 1987 May 01; 138(9):2941-8. View in: Pubmed

      • Fibronectin receptor structures in the VLA family of heterodimers. Nature. 1987 Apr 9-15; 326(6113):607-9. View in: Pubmed

      • The VLA protein family. Characterization of five distinct cell surface heterodimers each with a common 130,000 molecular weight beta subunit. J Biol Chem. 1987 Mar 05; 262(7):3300-9. View in: Pubmed

      • Use of the monoclonal antibody 12F1 to characterize the differentiation antigen VLA-2. J Immunol. 1987 Jan 01; 138(1):226-33. View in: Pubmed

      • Very late activation antigens on rheumatoid synovial fluid T lymphocytes. Association with stages of T cell activation. J Clin Invest. 1986 Sep; 78(3):696-702. View in: Pubmed

      • Biochemical characterization of VLA-1 and VLA-2. Cell surface heterodimers on activated T cells. J Biol Chem. 1985 Dec 05; 260(28):15246-52. View in: Pubmed

      • Investigation of in vivo activated T cells in multiple sclerosis and inflammatory central nervous system diseases. Clin Immunol Immunopathol. 1985 Nov; 37(2):163-71. View in: Pubmed

      • VLA-1: a T cell surface antigen which defines a novel late stage of human T cell activation. Eur J Immunol. 1985 May; 15(5):502-8. View in: Pubmed

      • Glycoproteins of 210,000 and 130,000 m.w. on activated T cells: cell distribution and antigenic relation to components on resting cells and T cell lines. J Immunol. 1984 Jun; 132(6):3011-8. View in: Pubmed

      • Genetic and biochemical characterization of human lymphocyte cell surface antigens. The A-1A5 and A-3A4 determinants. J Exp Med. 1984 May 01; 159(5):1441-54. View in: Pubmed

      • Antigenic stimulation regulates the level of expression of interleukin 2 receptor on human T cells. Proc Natl Acad Sci U S A. 1984 Apr; 81(7):2172-5. View in: Pubmed

      • A 55,000 Mr surface antigen on activated human T lymphocytes defined by a monoclonal antibody. Hum Immunol. 1983 Oct; 8(2):153-65. View in: Pubmed

      • Differentiation of human T lymphocytes. I. Acquisition of a novel human cell surface protein (p80) during normal intrathymic T cell maturation. J Immunol. 1983 Sep; 131(3):1195-200. View in: Pubmed

      • Characterization of a novel differentiation antigen complex recognize by a monoclonal antibody (A-1A5): unique activation-specific molecular forms on stimulated T cells. J Immunol. 1983 Jul; 131(1):334-40. View in: Pubmed

      • Cytotoxic T cells directed against HLA-DR antigens and their surface proteins. Diagn Immunol. 1983; 1(3):116-9. View in: Pubmed

      • Monoclonal antibodies reacting with immunogenic mycoplasma proteins present in human hematopoietic cell lines. J Immunol. 1982 Dec; 129(6):2734-8. View in: Pubmed

      • Genetic and biochemical characterization of a human surface determinant on somatic cell hybrids: the 4F2 antigen. Somatic Cell Genet. 1982 Nov; 8(6):825-34. View in: Pubmed

      • Characterization of antigen recognized by the monoclonal antibody (4F2): different molecular forms on human T and B lymphoblastoid cell lines. J Immunol. 1982 Aug; 129(2):623-8. View in: Pubmed

      • Description of monoclonal antibody defining an HLA allotypic determinant that includes specificities within the B5 cross-reacting group. Hum Immunol. 1982 Jul; 4(4):273-85. View in: Pubmed

      • Characterization of a monoclonal antibody (5E9) that defines a human cell surface antigen of cell activation. J Immunol. 1981 Jul; 127(1):347-51. View in: Pubmed

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      • Characterization of a monoclonal antibody (4F2) that binds to human monocytes and to a subset of activated lymphocytes. J Immunol. 1981 Apr; 126(4):1409-14. View in: Pubmed

      • Human T cell proteins recognized by rabbit heteroantisera and monoclonal antibodies. Int J Immunopharmacol. 1981; 3(3):255-68. View in: Pubmed

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      • Evidence for a peroxide-initiated free radical mechanism of prostaglandin biosynthesis. J Biol Chem. 1980 Jul 10; 255(13):6253-61. View in: Pubmed

      • Characterization of a monoclonal antibody that defines an immunoregulatory T cell subset for immunoglobulin synthesis in humans. Proc Natl Acad Sci U S A. 1980 May; 77(5):2914-8. View in: Pubmed

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      • Biosynthesis of prostaglandins. Lipids. 1977 Jul; 12(7):591-5. View in: Pubmed

      • Purification of the cyclooxygenase that forms prostaglandins. Demonstration of two forms of iron in the holoenzyme. J Biol Chem. 1976 Sep 25; 251(18):5575-9. View in: Pubmed

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      450 Brookline Avenue Dana 1430 Boston, MA 02215
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      42.3374, -71.1082

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