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Martin E. Hemler, PhD


Researcher

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Martin E. Hemler, PhD

Researcher

  • Principal Investigator, Cancer Immunology and Virology, Dana-Farber Cancer Institute
  • Professor of Pathology, Brigham and Women’s Hospital

Contact Information

  • Office Phone Number(617) 632-3410
  • Fax(617) 632-2662

Bio

Dr. Hemler received his PhD in biological chemistry from the University of Michigan in 1978. After postdoctoral research at DFCI from 1979 to 1984, he received a faculty appointment at DFCI and was promoted to professor in 1994. He is exclusively involved in basic laboratory research, focusing on cell surface molecules that participate in cell adhesion, migration, and invasion.

Research

Novel adhesion and palmitoylation mechanisms that regulate the tumor microenvironment

Cell adhesion is a basic process in cell biology, controlling cell growth, death, differentiation, movement, and tissue organization in normal cells, as well as the proliferation and metastasis of tumor cells. The Hemler Lab focuses on the molecular basis for cell adhesion and migration. In particular, they are interested in the structures and functions of heterodimers in the INTEGRIN family, including studies of the mechanisms whereby integrin functions are rapidly turned on and off, and different integrins link to distinct cellular signaling pathways. In addition, they study other cell surface transmembrane proteins that associate with integrins. Recent studies have shown that transmembrane linker proteins, called tetraspanin proteins, allow the membrane proximal extracellular domains of integrins to play key roles in the recruitment of intracellular signaling enzymes such as protein kinase C, and phosphatidylinositol 4-kinase.

Recent studies have focused on how certain integrins may be linked to regulation of matrix metalloproteinase (MMP) production, a key process during cell and tissue remodeling and tumor cell metastasis. Most recently, they have generated mutant mice in which the tetraspanin CD151 gene has been deleted to investigate the role of CD151 during tumor progression.

Antioxidant and Anticancer Functions of Protein Acyltransferase DHHC3. Antioxidants (Basel). 2022 May 12; 11(5).
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Antioxidant functions of DHHC3 suppress anti-cancer drug activities. Cell Mol Life Sci. 2021 Mar; 78(5):2341-2353.
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Integrin-independent support of cancer drug resistance by tetraspanin CD151. Cell Mol Life Sci. 2019 Apr; 76(8):1595-1604.
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Multiple pro-tumor roles for protein acyltransferase DHHC3. Oncoscience. 2017 Nov; 4(11-12):152-153.
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Protein Acyltransferase DHHC3 Regulates Breast Tumor Growth, Oxidative Stress, and Senescence. Cancer Res. 2017 12 15; 77(24):6880-6890.
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Novel impact of EWI-2, CD9, and CD81 on TGF-ß signaling in melanoma. Mol Cell Oncol. 2015 Oct 02; 2(1).
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EWI-2 negatively regulates TGF-ß signaling leading to altered melanoma growth and metastasis. Cell Res. 2015 Mar; 25(3):370-85.
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Tetraspanin proteins promote multiple cancer stages. Nat Rev Cancer. 2014 Jan; 14(1):49-60.
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Tetraspanin proteins promote multiple cancer stages. Nat Rev Cancer. 2013 Dec 23; 14(1):49-60.
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Tetraspanin TSPAN12 regulates tumor growth and metastasis and inhibits ß-catenin degradation. Cell Mol Life Sci. 2014 Apr; 71(7):1305-14.
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Renal disease appears not to affect carcinogenesis in CD151-null mice. Oncogene. 2013 Sep 12; 32(37):4458.
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Integrin-associated CD151 drives ErbB2-evoked mammary tumor onset and metastasis. Neoplasia. 2012 Aug; 14(8):678-89.
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Tetraspanin CD151 plays a key role in skin squamous cell carcinoma. Oncogene. 2013 Apr 04; 32(14):1772-83.
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Palmitoylation by DHHC3 is critical for the function, expression, and stability of integrin a6ß4. Cell Mol Life Sci. 2012 Jul; 69(13):2233-44.
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Tetraspanin CD151 protects against pulmonary fibrosis by maintaining epithelial integrity. Am J Respir Crit Care Med. 2012 Jul 15; 186(2):170-80.
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Transcriptional profiling of stroma from inflamed and resting lymph nodes defines immunological hallmarks. Nat Immunol. 2012 Apr 01; 13(5):499-510.
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CD151 restricts the a6 integrin diffusion mode. J Cell Sci. 2012 Mar 15; 125(Pt 6):1478-87.
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The C-terminal tail of tetraspanin protein CD9 contributes to its function and molecular organization. J Cell Sci. 2011 Aug 15; 124(Pt 16):2702-10.
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Diminished metastasis in tetraspanin CD151-knockout mice. Blood. 2011 Jul 14; 118(2):464-72.
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Tetraspanin protein contributions to cancer. Biochem Soc Trans. 2011 Apr; 39(2):547-52.
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Disruption of laminin-integrin-CD151-focal adhesion kinase axis sensitizes breast cancer cells to ErbB2 antagonists. Cancer Res. 2010 Mar 15; 70(6):2256-63.
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Tetraspanin12 regulates ADAM10-dependent cleavage of amyloid precursor protein. FASEB J. 2009 Nov; 23(11):3674-81.
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Tetraspanin proteins regulate membrane type-1 matrix metalloproteinase-dependent pericellular proteolysis. Mol Biol Cell. 2009 Apr; 20(7):2030-40.
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Glioblastoma inhibition by cell surface immunoglobulin protein EWI-2, in vitro and in vivo. Neoplasia. 2009 Jan; 11(1):77-86, 4p following 86.
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Overexpression of fatty acid synthase is associated with palmitoylation of Wnt1 and cytoplasmic stabilization of beta-catenin in prostate cancer. Lab Invest. 2008 Dec; 88(12):1340-8.
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Targeting of tetraspanin proteins--potential benefits and strategies. Nat Rev Drug Discov. 2008 Sep; 7(9):747-58.
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DHHC2 affects palmitoylation, stability, and functions of tetraspanins CD9 and CD151. Mol Biol Cell. 2008 Aug; 19(8):3415-25.
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CD151 accelerates breast cancer by regulating alpha 6 integrin function, signaling, and molecular organization. Cancer Res. 2008 May 01; 68(9):3204-13.
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A novel cysteine cross-linking method reveals a direct association between claudin-1 and tetraspanin CD9. Mol Cell Proteomics. 2007 Nov; 6(11):1855-67.
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Deletion of tetraspanin Cd151 results in decreased pathologic angiogenesis in vivo and in vitro. Blood. 2007 Feb 15; 109(4):1524-32.
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In vitro interaction between hepatitis C virus (HCV) envelope glycoprotein E2 and serum lipoproteins (LPs) results in enhanced cellular binding of both HCV E2 and LPs. J Infect Dis. 2006 Oct 15; 194(8):1058-67.
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EWI-2 and EWI-F link the tetraspanin web to the actin cytoskeleton through their direct association with ezrin-radixin-moesin proteins. J Biol Chem. 2006 Jul 14; 281(28):19665-75.
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Contrasting effects of EWI proteins, integrins, and protein palmitoylation on cell surface CD9 organization. J Biol Chem. 2006 May 05; 281(18):12976-85.
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Tetraspanin functions and associated microdomains. Nat Rev Mol Cell Biol. 2005 Oct; 6(10):801-11.
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Structural organization and interactions of transmembrane domains in tetraspanin proteins. BMC Struct Biol. 2005 Jun 28; 5:11.
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Metabolic activation-related CD147-CD98 complex. Mol Cell Proteomics. 2005 Aug; 4(8):1061-71.
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Palmitoylation supports assembly and function of integrin-tetraspanin complexes. J Cell Biol. 2004 Dec 20; 167(6):1231-40.
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Links between CD147 function, glycosylation, and caveolin-1. Mol Biol Cell. 2004 Sep; 15(9):4043-50.
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Dynamic regulation of a GPCR-tetraspanin-G protein complex on intact cells: central role of CD81 in facilitating GPR56-Galpha q/11 association. Mol Biol Cell. 2004 May; 15(5):2375-87.
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Evidence for specific tetraspanin homodimers: inhibition of palmitoylation makes cysteine residues available for cross-linking. Biochem J. 2004 Jan 15; 377(Pt 2):407-17.
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Caveolin-1 regulates matrix metalloproteinases-1 induction and CD147/EMMPRIN cell surface clustering. J Biol Chem. 2004 Mar 19; 279(12):11112-8.
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EWI-2 modulates lymphocyte integrin alpha4beta1 functions. Blood. 2004 Apr 15; 103(8):3013-9.
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EWI-2 regulates alpha3beta1 integrin-dependent cell functions on laminin-5. J Cell Biol. 2003 Dec 08; 163(5):1167-77.
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Tetraspanin CD151 regulates alpha6beta1 integrin adhesion strengthening. Proc Natl Acad Sci U S A. 2003 Jun 24; 100(13):7616-21.
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Functional domains in tetraspanin proteins. Trends Biochem Sci. 2003 Feb; 28(2):106-12.
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Tetraspanin proteins mediate cellular penetration, invasion, and fusion events and define a novel type of membrane microdomain. Annu Rev Cell Dev Biol. 2003; 19:397-422.
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An extracellular site on tetraspanin CD151 determines alpha 3 and alpha 6 integrin-dependent cellular morphology. J Cell Biol. 2002 Sep 30; 158(7):1299-309.
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Palmitoylation of tetraspanin proteins: modulation of CD151 lateral interactions, subcellular distribution, and integrin-dependent cell morphology. Mol Biol Cell. 2002 Mar; 13(3):767-81.
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Function of the tetraspanin CD151-alpha6beta1 integrin complex during cellular morphogenesis. Mol Biol Cell. 2002 Jan; 13(1):1-11.
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Specific tetraspanin functions. J Cell Biol. 2001 Dec 24; 155(7):1103-7.
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Retooling of the beta 4 integrin in tumor cells--ligands lost and kinase gained. Dev Cell. 2001 Dec; 1(6):728-30.
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Beta1 integrins show specific association with CD98 protein in low density membranes. BMC Biochem. 2001; 2:10.
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EWI-2 is a major CD9 and CD81 partner and member of a novel Ig protein subfamily. J Biol Chem. 2001 Nov 02; 276(44):40545-54.
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Transmembrane-4 superfamily proteins associate with activated protein kinase C (PKC) and link PKC to specific beta(1) integrins. J Biol Chem. 2001 Jul 06; 276(27):25005-13.
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Regulation of MMP-1 and MMP-2 production through CD147/extracellular matrix metalloproteinase inducer interactions. Cancer Res. 2001 Mar 01; 61(5):2276-81.
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Phosphorylation of a conserved integrin alpha 3 QPSXXE motif regulates signaling, motility, and cytoskeletal engagement. Mol Biol Cell. 2001 Feb; 12(2):351-65.
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Evaluation of prototype transmembrane 4 superfamily protein complexes and their relation to lipid rafts. J Biol Chem. 2001 Mar 16; 276(11):7974-84.
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FPRP, a major, highly stoichiometric, highly specific CD81- and CD9-associated protein. J Biol Chem. 2001 Feb 16; 276(7):4853-62.
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Specific interactions among transmembrane 4 superfamily (TM4SF) proteins and phosphoinositide 4-kinase. Biochem J. 2000 Nov 01; 351 Pt 3:629-37.
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Cell-to-cell contact and extracellular matrix. Editorial overview Curr Opin Cell Biol. 2000 Oct; 12(5):539-41.
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Transmembrane-4-superfamily proteins CD151 and CD81 associate with alpha 3 beta 1 integrin, and selectively contribute to alpha 3 beta 1-dependent neurite outgrowth. J Cell Sci. 2000 Jun; 113 ( Pt 11):1871-82.
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Direct extracellular contact between integrin alpha(3)beta(1) and TM4SF protein CD151. J Biol Chem. 2000 Mar 31; 275(13):9230-8.
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Role of transmembrane 4 superfamily (TM4SF) proteins CD9 and CD81 in muscle cell fusion and myotube maintenance. J Cell Biol. 1999 Aug 23; 146(4):893-904.
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Trio amino-terminal guanine nucleotide exchange factor domain expression promotes actin cytoskeleton reorganization, cell migration and anchorage-independent cell growth. J Cell Sci. 1999 Jun; 112 ( Pt 12):1825-34.
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Dystroglycan versatility. Cell. 1999 May 28; 97(5):543-6.
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Interaction of the integrin beta1 cytoplasmic domain with ICAP-1 protein. J Biol Chem. 1999 Jan 01; 274(1):11-9.
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The light chain of CD98 is identified as E16/TA1 protein. J Biol Chem. 1998 Dec 11; 273(50):33127-9.
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Highly stoichiometric, stable, and specific association of integrin alpha3beta1 with CD151 provides a major link to phosphatidylinositol 4-kinase, and may regulate cell migration. Mol Biol Cell. 1998 Oct; 9(10):2751-65.
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Beta1 integrin cytoplasmic domain regulates the constitutive conformation detected by MAb 15/7, but not the ligand-induced conformation. J Cell Biochem. 1998 Oct 01; 71(1):63-73.
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Integrin associated proteins. Curr Opin Cell Biol. 1998 Oct; 10(5):578-85.
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Recombinant soluble human alpha 3 beta 1 integrin: purification, processing, regulation, and specific binding to laminin-5 and invasin in a mutually exclusive manner. Biochemistry. 1998 Aug 04; 37(31):10945-55.
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Divalent cations and ligands induce conformational changes that are highly divergent among beta1 integrins. J Biol Chem. 1998 Mar 20; 273(12):6670-8.
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Are changes in integrin affinity and conformation overemphasized? Trends Biochem Sci. 1998 Jan; 23(1):30-4.
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Defining extracellular integrin alpha-chain sites that affect cell adhesion and adhesion strengthening without altering soluble ligand binding. Mol Biol Cell. 1997 Dec; 8(12):2647-57.
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NAG-2, a novel transmembrane-4 superfamily (TM4SF) protein that complexes with integrins and other TM4SF proteins. J Biol Chem. 1997 Nov 14; 272(46):29181-9.
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Generation of monoclonal antibodies to integrin-associated proteins. Evidence that alpha3beta1 complexes with EMMPRIN/basigin/OX47/M6. J Biol Chem. 1997 Nov 14; 272(46):29174-80.
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Mutational evidence for control of cell adhesion through integrin diffusion/clustering, independent of ligand binding. J Exp Med. 1997 Oct 20; 186(8):1347-55.
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A novel link between integrins, transmembrane-4 superfamily proteins (CD63 and CD81), and phosphatidylinositol 4-kinase. J Biol Chem. 1997 Jan 31; 272(5):2595-8.
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Integrin alpha chain cytoplasmic tails regulate "antibody-redirected" cell adhesion, independently of ligand binding. Eur J Immunol. 1997 Jan; 27(1):78-84.
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Transmembrane-4 superfamily proteins CD81 (TAPA-1), CD82, CD63, and CD53 specifically associated with integrin alpha 4 beta 1 (CD49d/CD29). J Immunol. 1996 Sep 01; 157(5):2039-47.
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Intracellular single-chain antibody inhibits integrin VLA-4 maturation and function. Biochem J. 1996 Sep 01; 318 ( Pt 2):591-6.
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Bcr/Abl expression stimulates integrin function in hematopoietic cell lines. J Clin Invest. 1996 Jul 15; 98(2):521-8.
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Reduction of tumorigenicity by alpha 3 integrin in a rhabdomyosarcoma cell line. Cell Adhes Commun. 1996 Jul; 4(1):41-52.
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Association of TM4SF proteins with integrins: relevance to cancer. Biochim Biophys Acta. 1996 Jun 07; 1287(2-3):67-71.
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Characterization of novel complexes on the cell surface between integrins and proteins with 4 transmembrane domains (TM4 proteins). Mol Biol Cell. 1996 Feb; 7(2):193-207.
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Integrin alpha 4 cysteines 278 and 717 modulate VLA-4 ligand binding and also contribute to alpha 4/180 formation. Biochem J. 1996 Feb 01; 313 ( Pt 3):899-908.
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Investigation of the role of beta 1 integrins in cell-cell adhesion. J Cell Sci. 1995 Nov; 108 ( Pt 11):3635-44.
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Monoclonal antibody 9EG7 defines a novel beta 1 integrin epitope induced by soluble ligand and manganese, but inhibited by calcium. J Biol Chem. 1995 Oct 27; 270(43):25570-7.
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Specific association of CD63 with the VLA-3 and VLA-6 integrins. J Biol Chem. 1995 Jul 28; 270(30):17784-90.
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Molecular mapping of functional antibody binding sites of alpha 4 integrin. J Biol Chem. 1995 Jun 16; 270(24):14270-3.
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Specialized functional properties of the integrin alpha 4 cytoplasmic domain. Mol Biol Cell. 1995 Jun; 6(6):661-74.
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Integrin-ligand binding. Do integrins use a 'MIDAS touch' to grasp an Asp? Curr Biol. 1995 Jun 01; 5(6):615-7.
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The integrin VLA-4 supports tethering and rolling in flow on VCAM-1. J Cell Biol. 1995 Mar; 128(6):1243-53.
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Integrin-mediated collagen matrix reorganization by cultured human vascular smooth muscle cells. Circ Res. 1995 Feb; 76(2):209-14.
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The leukocyte beta 1 integrins. Curr Opin Hematol. 1995 Jan; 2(1):61-7.
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The pathophysiologic role of alpha 4 integrins in vivo. J Clin Invest. 1994 Nov; 94(5):1722-8.
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The I domain is essential for echovirus 1 interaction with VLA-2. Cell Adhes Commun. 1994 Oct; 2(5):455-64.
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Integrin alpha 2 cytoplasmic domain deletion effects: loss of adhesive activity parallels ligand-independent recruitment into focal adhesions. Mol Biol Cell. 1994 Sep; 5(9):977-88.
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Minimum alpha chain cytoplasmic tail sequence needed to support integrin-mediated adhesion. J Biol Chem. 1994 Aug 05; 269(31):19859-67.
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Proteolytic cleavage of the integrin beta 4 subunit. Exp Cell Res. 1994 May; 212(1):2-9.
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Contrasting roles for integrin beta 1 and beta 5 cytoplasmic domains in subcellular localization, cell proliferation, and cell migration. J Cell Biol. 1994 Apr; 125(2):447-60.
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Mutation of putative divalent cation sites in the alpha 4 subunit of the integrin VLA-4: distinct effects on adhesion to CS1/fibronectin, VCAM-1, and invasin. J Cell Biol. 1993 Oct; 123(1):245-53.
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Role of the alpha subunit cytoplasmic domain in regulation of adhesive activity mediated by the integrin VLA-2. J Biol Chem. 1993 Aug 05; 268(22):16279-85.
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Adhesion molecules: cellular recognition mechanisms. The Pezcoller Foundation Symposia, Rovereto, June 24-26, 1992. Ann Oncol. 1993 Aug; 4(7):545-7.
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Interchangeable alpha chain cytoplasmic domains play a positive role in control of cell adhesion mediated by VLA-4, a beta 1 integrin. J Exp Med. 1993 Aug 01; 178(2):649-60.
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The integrin VLA-2 binds echovirus 1 and extracellular matrix ligands by different mechanisms. J Clin Invest. 1993 Jul; 92(1):232-9.
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A study of the structure, function and distribution of beta 5 integrins using novel anti-beta 5 monoclonal antibodies. J Cell Sci. 1993 May; 105 ( Pt 1):101-11.
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Fourth annual Pezcoller Symposium--adhesion molecules: cellular recognition mechanisms. Cancer Res. 1993 May 01; 53(9):2192-4.
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The function and distinctive regulation of the integrin VLA-3 in cell adhesion, spreading, and homotypic cell aggregation. J Biol Chem. 1993 Apr 25; 268(12):8651-7.
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Alpha 4/180, a novel form of the integrin alpha 4 subunit. J Biol Chem. 1993 Apr 05; 268(10):7028-35.
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Multiple activation states of VLA-4. Mechanistic differences between adhesion to CS1/fibronectin and to vascular cell adhesion molecule-1. J Biol Chem. 1993 Jan 05; 268(1):228-34.
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Multiple functional forms of the integrin VLA-2 can be derived from a single alpha 2 cDNA clone: interconversion of forms induced by an anti-beta 1 antibody. J Cell Biol. 1993 Jan; 120(2):537-43.
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Functional role of alpha 2/beta 1 and alpha 4/beta 1 integrins in leukocyte intercellular adhesion induced through the common beta 1 subunit. Eur J Immunol. 1992 Dec; 22(12):3111-9.
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Role of beta 1 and beta 2 integrins in the adhesion of human CD34hi stem cells to bone marrow stroma. J Clin Invest. 1992 Aug; 90(2):358-67.
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Adhesion to vascular cell adhesion molecule 1 and fibronectin. Comparison of alpha 4 beta 1 (VLA-4) and alpha 4 beta 7 on the human B cell line JY. J Biol Chem. 1992 Apr 25; 267(12):8366-70.
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Identification of the integrin VLA-2 as a receptor for echovirus 1. Science. 1992 Mar 27; 255(5052):1718-20.
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Distinct cellular functions mediated by different VLA integrin alpha subunit cytoplasmic domains. Cell. 1992 Mar 20; 68(6):1051-60.
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Functional and structural analysis of VLA-4 integrin alpha 4 subunit cleavage. J Biol Chem. 1992 Jan 25; 267(3):1786-91.
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Analyses of VLA-4 structure and function. Adv Exp Med Biol. 1992; 323:163-70.
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Functional roles for integrin alpha subunit cytoplasmic domains. Cold Spring Harb Symp Quant Biol. 1992; 57:213-20.
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Cloning and expression of cDNAs for the alpha subunit of the murine lymphocyte-Peyer's patch adhesion molecule. J Cell Biol. 1991 Nov; 115(4):1149-58.
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Integrin alpha 2 beta 1 (VLA-2) mediates reorganization and contraction of collagen matrices by human cells. Cell. 1991 Oct 18; 67(2):403-10.
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Molecular cloning and expression of the cDNA for alpha 3 subunit of human alpha 3 beta 1 (VLA-3), an integrin receptor for fibronectin, laminin, and collagen. J Cell Biol. 1991 Oct; 115(1):257-66.
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T cell receptor-dependent, antigen-specific stimulation of a murine T cell clone induces a transient, VLA protein-mediated binding to extracellular matrix. J Immunol. 1991 Jul 15; 147(2):398-404.
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Functional evidence for three distinct and independently inhibitable adhesion activities mediated by the human integrin VLA-4. Correlation with distinct alpha 4 epitopes. J Biol Chem. 1991 Jun 05; 266(16):10241-5.
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In vitro and in vivo consequences of VLA-2 expression on rhabdomyosarcoma cells. Science. 1991 Mar 29; 251(5001):1600-2.
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Receptor functions for the integrin VLA-3: fibronectin, collagen, and laminin binding are differentially influenced by Arg-Gly-Asp peptide and by divalent cations. J Cell Biol. 1991 Jan; 112(1):169-81.
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Multiple ligand binding functions for VLA-2 (alpha 2 beta 1) and VLA-3 (alpha 3 beta 1) in the integrin family. Cell Differ Dev. 1990 Dec 02; 32(3):229-38.
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Cloning, primary structure and properties of a novel human integrin beta subunit. EMBO J. 1990 May; 9(5):1561-8.
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Structure of the integrin VLA-4 and its cell-cell and cell-matrix adhesion functions. Immunol Rev. 1990 Apr; 114:45-65.
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VCAM-1 on activated endothelium interacts with the leukocyte integrin VLA-4 at a site distinct from the VLA-4/fibronectin binding site. Cell. 1990 Feb 23; 60(4):577-84.
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VLA proteins in the integrin family: structures, functions, and their role on leukocytes. Annu Rev Immunol. 1990; 8:365-400.
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The human integrin VLA-2 is a collagen receptor on some cells and a collagen/laminin receptor on others. Proc Natl Acad Sci U S A. 1989 Dec; 86(24):9906-10.
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Analysis of the tumor-associated antigen TSP-180. Identity with alpha 6-beta 4 in the integrin superfamily. J Biol Chem. 1989 Sep 15; 264(26):15515-21.
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A novel monoclonal antibody, 1B3.1, binds to a new epitope of the VLA-1 molecule. Cell Immunol. 1989 Sep; 122(2):416-23.
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The primary structure of the VLA-2/collagen receptor alpha 2 subunit (platelet GPIa): homology to other integrins and the presence of a possible collagen-binding domain. J Cell Biol. 1989 Jul; 109(1):397-407.
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The primary structure of the alpha 4 subunit of VLA-4: homology to other integrins and a possible cell-cell adhesion function. EMBO J. 1989 May; 8(5):1361-8.
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Association of the VLA alpha 6 subunit with a novel protein. A possible alternative to the common VLA beta 1 subunit on certain cell lines. J Biol Chem. 1989 Apr 15; 264(11):6529-35.
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Regulation of cell adhesion receptors by transforming growth factor-beta. Concomitant regulation of integrins that share a common beta 1 subunit. J Biol Chem. 1989 Jan 05; 264(1):380-8.
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Extracellular matrix receptors, ECMRII and ECMRI, for collagen and fibronectin correspond to VLA-2 and VLA-3 in the VLA family of heterodimers. J Cell Biochem. 1988 Aug; 37(4):385-93.
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Regulation of proteins in the VLA cell substrate adhesion family: influence of cell growth conditions on VLA-1, VLA-2, and VLA-3 expression. Exp Cell Res. 1988 Jul; 177(1):132-42.
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Multiple very late antigen (VLA) heterodimers on platelets. Evidence for distinct VLA-2, VLA-5 (fibronectin receptor), and VLA-6 structures. J Biol Chem. 1988 Jun 05; 263(16):7660-5.
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Adhesive protein receptors on hematopoietic cells. Immunol Today. 1988 Apr; 9(4):109-13.
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T lymphocytes compartmentalized on the epithelial surface of the lower respiratory tract express the very late activation antigen complex VLA-1. Clin Immunol Immunopathol. 1988 Feb; 46(2):221-33.
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Characterization of the cell surface heterodimer VLA-4 and related peptides. J Biol Chem. 1987 Aug 25; 262(24):11478-85.
View in: PubMed

The very late antigen family of heterodimers is part of a superfamily of molecules involved in adhesion and embryogenesis. Proc Natl Acad Sci U S A. 1987 May; 84(10):3239-43.
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Cell matrix adhesion-related proteins VLA-1 and VLA-2: regulation of expression on T cells. J Immunol. 1987 May 01; 138(9):2941-8.
View in: PubMed

Fibronectin receptor structures in the VLA family of heterodimers. Nature. 1987 Apr 9-15; 326(6113):607-9.
View in: PubMed

The VLA protein family. Characterization of five distinct cell surface heterodimers each with a common 130,000 molecular weight beta subunit. J Biol Chem. 1987 Mar 05; 262(7):3300-9.
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Use of the monoclonal antibody 12F1 to characterize the differentiation antigen VLA-2. J Immunol. 1987 Jan 01; 138(1):226-33.
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Very late activation antigens on rheumatoid synovial fluid T lymphocytes. Association with stages of T cell activation. J Clin Invest. 1986 Sep; 78(3):696-702.
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Biochemical characterization of VLA-1 and VLA-2. Cell surface heterodimers on activated T cells. J Biol Chem. 1985 Dec 05; 260(28):15246-52.
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Investigation of in vivo activated T cells in multiple sclerosis and inflammatory central nervous system diseases. Clin Immunol Immunopathol. 1985 Nov; 37(2):163-71.
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VLA-1: a T cell surface antigen which defines a novel late stage of human T cell activation. Eur J Immunol. 1985 May; 15(5):502-8.
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Glycoproteins of 210,000 and 130,000 m.w. on activated T cells: cell distribution and antigenic relation to components on resting cells and T cell lines. J Immunol. 1984 Jun; 132(6):3011-8.
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Genetic and biochemical characterization of human lymphocyte cell surface antigens. The A-1A5 and A-3A4 determinants. J Exp Med. 1984 May 01; 159(5):1441-54.
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Antigenic stimulation regulates the level of expression of interleukin 2 receptor on human T cells. Proc Natl Acad Sci U S A. 1984 Apr; 81(7):2172-5.
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A 55,000 Mr surface antigen on activated human T lymphocytes defined by a monoclonal antibody. Hum Immunol. 1983 Oct; 8(2):153-65.
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Differentiation of human T lymphocytes. I. Acquisition of a novel human cell surface protein (p80) during normal intrathymic T cell maturation. J Immunol. 1983 Sep; 131(3):1195-200.
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Characterization of a novel differentiation antigen complex recognize by a monoclonal antibody (A-1A5): unique activation-specific molecular forms on stimulated T cells. J Immunol. 1983 Jul; 131(1):334-40.
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Cytotoxic T cells directed against HLA-DR antigens and their surface proteins. Diagn Immunol. 1983; 1(3):116-9.
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Monoclonal antibodies reacting with immunogenic mycoplasma proteins present in human hematopoietic cell lines. J Immunol. 1982 Dec; 129(6):2734-8.
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Genetic and biochemical characterization of a human surface determinant on somatic cell hybrids: the 4F2 antigen. Somatic Cell Genet. 1982 Nov; 8(6):825-34.
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Characterization of antigen recognized by the monoclonal antibody (4F2): different molecular forms on human T and B lymphoblastoid cell lines. J Immunol. 1982 Aug; 129(2):623-8.
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Description of monoclonal antibody defining an HLA allotypic determinant that includes specificities within the B5 cross-reacting group. Hum Immunol. 1982 Jul; 4(4):273-85.
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Characterization of a monoclonal antibody (5E9) that defines a human cell surface antigen of cell activation. J Immunol. 1981 Jul; 127(1):347-51.
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Dissection of distinct human immunoregulatory T-cell subsets by a monoclonal antibody recognizing a cell surface antigen with wide tissue distribution. Proc Natl Acad Sci U S A. 1981 May; 78(5):3160-4.
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Characterization of a monoclonal antibody (4F2) that binds to human monocytes and to a subset of activated lymphocytes. J Immunol. 1981 Apr; 126(4):1409-14.
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Human T cell proteins recognized by rabbit heteroantisera and monoclonal antibodies. Int J Immunopharmacol. 1981; 3(3):255-68.
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Development and characterization of allospecific long-term human cytolytic T-cell lines. Proc Natl Acad Sci U S A. 1980 Sep; 77(9):5432-6.
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Evidence for a peroxide-initiated free radical mechanism of prostaglandin biosynthesis. J Biol Chem. 1980 Jul 10; 255(13):6253-61.
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Characterization of a monoclonal antibody that defines an immunoregulatory T cell subset for immunoglobulin synthesis in humans. Proc Natl Acad Sci U S A. 1980 May; 77(5):2914-8.
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Protection of cyclooxygenase activity during heme-induced destabilization. Arch Biochem Biophys. 1980 May; 201(2):586-93.
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Prostaglandin biosynthesis can be triggered by lipid peroxides. Arch Biochem Biophys. 1979 Apr 01; 193(2):340-5.
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Accelerative autoactivation of prostaglandin biosynthesis by PGG2. Biochem Biophys Res Commun. 1978 Dec 29; 85(4):1325-31.
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Lipoxygenation activity of purified prostaglandin-forming cyclooxygenase. Biochemistry. 1978 May 02; 17(9):1772-9.
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Synthesis of prostaglandin synthetase substrate analogues. 2. (8Z,11Z,14Z)-15-Methyl-8,11,14-eicosatrienoic acid. J Med Chem. 1977 Nov; 20(11):1396-400.
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Biosynthesis of prostaglandins. Lipids. 1977 Jul; 12(7):591-5.
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Purification of the cyclooxygenase that forms prostaglandins. Demonstration of two forms of iron in the holoenzyme. J Biol Chem. 1976 Sep 25; 251(18):5575-9.
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