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Michael J. Vasconcelles, MD


Medical Oncology

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Michael J. Vasconcelles, MD

Physician

  • Instructor in Medicine, Harvard Medical School

Centers/Programs

Clinical Interests

  • Hematologic malignancies
  • Thoracic oncology

Contact Information

  • Appointments877-332-4294 (new)
    617-632-6190 (established)
  • Office Phone Number617-632-6049
  • Fax617-632-5786

Bio

Dr. Vasconcelles received his MD from Northwestern University in 1989. He completed his postgraduate training in internal medicine at Beth Israel Hospital and in hematology-oncology at Brigham and Women's Hospital. He then taught at BWH until 1999, when he joined the DFCI staff in the Lowe Center for Thoracic Oncology.

Board Certification:

  • Hematology, 1996
  • Medical Oncology, 1998

Fellowship:

  • Brigham and Women's Hospital, Hematology & Oncology

Residency:

  • Beth Israel Hospital, Internal Medicine

Medical School:

  • Northwestern University Medical School

Research



Novel Oncologic Therapeutics and Oxygen Sensing





Over the past 25 years, Dr. Vasconcelles’ research interests in oncology have primarily focused on areas within tumor biology broadly referred to as non oncogene addiction, and more recently the emerging area of immuno-oncology. Several years ago in the laboratory, we established a eukaryotic model system using Saccharomyces cerevisiae (Baker’s yeast) to better understand the adaptive response to low oxygen tension. We learned that changes in gene expression in yeast, in response to hypoxia, are similar to higher eukaryotes in several fundamental ways, suggesting potential conservation of oxygen-sensing pathways.  



More recently, focus has turned to the development of novel cancer therapeutics based upon important discoveries and observations from several laboratories. Clinical research efforts have led to the development and approval of novel cancer medicines to treat chronic lymphocytic leukemia, pediatric acute lymphoblastic leukemia, Hodgkins’ lymphoma and anaplastic large cell lymphoma, mantle cell lymphoma, and multiple myeloma.  



Currently, our work is directed toward the development of genetically modified autologous T cell therapies in cancer, with potential broad applications across a variety of malignancies.



Our work has been published in peer-reviewed journals such as Eukaryotic Cell, Biology of Blood and Marrow Transplantation, Journal of Biological Chemistry, Molecular and Cellular Biology, Journal of Clinical Oncology, among others.

Vasconcelles MJ, Jiang Y, Wretzel S, Light A, Gilooly L, Martin CE, Goldberg MA. Mga2p processing by hypoxia and unsaturated fatty acids in S. cerevisiae: impact on LORE-dependent gene expression. Eukaryot Cell 2002;1(3):481-90.

Vasconcelles MJ, Bernardo MVP, King C, Weller EA, Antin JH. Aerosolized pentamidine as pneumocystis prophylaxis following bone marrow transplantation is inferior to other regimens and is associated with decreased survival and an increased risk of other infections. Biol Blood Marrow Transplant 2000;6:35-43.

Vasconcelles MJ, Jiang Y, McDaia K, Gilooly L, Wretzel S, Porter DL, Martin CE, Goldberg, MA. Identification and characterization of a low oxygen response element (LORE) involved in the hypoxic induction of a family of S. cerevisiae genes: implications for the conversation of oxygen sensing in eukaryotes. J Biol Chem 2001;276(17):14374-84.

Jiang Y, Vasconcelles MJ, Wretzel S, Light A, Martin CE, Goldberg MA. Mga2 is involved in the low-oxygen response element-dependent hypoxic induction of genes in Saccharomyces cerevisiae. Mol Cell Biol 2001;21(18):6161-9.

Location

Dana-Farber Cancer Institute
450 Brookline Avenue
Dana 1234
Boston, MA 02215
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