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Mizuki Nishino, MD, MPH


Radiology

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Mizuki Nishino, MD, MPH

Physician

  • Physician
  • Vice Chair of Faculty Development, Department of Imaging
  • Professor of Radiology, Harvard Medical School

Centers/Programs

Clinical Interests

  • Immunotherapy
  • Lung cancer
  • Oncologic imaging
  • Precision oncology
  • Thoracic imaging

Contact Information

  • Office Phone Number617-632-2595
  • Fax617-582-8574

Board Certification:

  • Diagnostic Radiology, 2008

Fellowship:

  • Beth Israel Deaconess Medical Center, Thoracic Imaging

Residency:

  • Beth Israel Deaconess Medical Center, Diagnostic Radiology

Medical School:

  • Kyoto University Faculty of Medicine, Japan

Recent Awards:

  • R01 award from the National Cancer Institute (PI: Nishino, 1R01CA203636, 2017-2021) “Automated in vivo analysis of tumor growth rate as a guide for therapeutic decisions to advance personalized cancer treatment” 2017
  • Magna Cum Laude- Dynamic Chest Radiography Using Flat Panel Detector System: Technique and Application. RSNA 2016, Chicago, IL, Nov 2016
  • Cum Laude- Thoracic Complications of Precision Cancer Therapies: A Practical Guide for Radiologists in the New Era of Cancer Care. RSNA 2016, Chicago, IL, Nov 2016
  • Merck Investigator Studies Program (PI: Nishino, 2016-2018). “Quantitative imaging analysis during pembrolizumab therapy in advanced melanoma patients: providing an objective marker for survival and therapeutic decisions” 2016
  • Editors' Recognition Award for Distinction in Reviewing, Journal of Thoracic Imaging. 2014, 2015
  • Diagnosis Please Award for Cases 205-216 published in 2014. Announcement in: Radiology. 2015; 277: 314-7. 2014
  • Diagnosis Please Award for Cases 181-192 published in 2012. Announcement in: Radiology. 2013; 269: 627-31. 2012
  • Dana-Farber Cancer Institute Fellowship for the Eleanor and Miles Shore 50th Anniversary Fellowship Program. (PI: Nishino, 2012) “Quantification of Apoptotic Activity in Non-small-cell Lung Cancer treated with Targeted Therapy: A pilot study.” 2012
  • K 23 Award from the National Cancer Institute (5K23CA157631, PI: Nishino, 2011-2016) “CT Volume Measurement of Lung Cancer treated with Erlotinib: Genomic Correlation” 2011
  • RSNA Research Scholar Grant, RSNA R&E Foundation (PI: Nishino, 2009-2011) "Chronological Analysis of Tumor Size, Volume and CT attenuation coefficient in Women with Adenocarcinoma of the Lung Treated with Erlotinib" 2009

Research

Interstitial lung abnormalities are associated with decreased mean telomere length. Eur Respir J. 2022 08; 60(2).
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Association of High Tumor Mutation Burden in Non-Small Cell Lung Cancers With Increased Immune Infiltration and Improved Clinical Outcomes of PD-L1 Blockade Across PD-L1 Expression Levels. JAMA Oncol. 2022 08 01; 8(8):1160-1168.
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Dissecting the clinicopathologic, genomic, and immunophenotypic correlates of KRASG12D-mutated non-small-cell lung cancer. Ann Oncol. 2022 10; 33(10):1029-1040.
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The relationship between interstitial lung abnormalities, mortality, and multimorbidity: a cohort study. Thorax. 2022 Jul 01.
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Blood gene expression risk profiles and interstitial lung abnormalities: COPDGene and ECLIPSE cohort studies. Respir Res. 2022 Jun 17; 23(1):157.
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Traction Bronchiectasis/Bronchiolectasis on CT Scans in Relationship to Clinical Outcomes and Mortality: The COPDGene Study. Radiology. 2022 09; 304(3):694-701.
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Concurrent TP53 Mutations Facilitate Resistance Evolution in EGFR-Mutant Lung Adenocarcinoma. J Thorac Oncol. 2022 06; 17(6):779-792.
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Multidisciplinary clinical guidance on trastuzumab deruxtecan (T-DXd)-related interstitial lung disease/pneumonitis-Focus on proactive monitoring, diagnosis, and management. Cancer Treat Rev. 2022 May; 106:102378.
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Radiomics-based Cluster Groups to Predict Clinical-Pathologic and Genomic Characteristics of Stage I Lung Adenocarcinoma. Radiology. 2022 06; 303(3):673-674.
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Interstitial Lung Abnormalities, Emphysema, and Spirometry in Smokers. Chest. 2022 04; 161(4):999-1010.
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Diminished Efficacy of Programmed Death-(Ligand)1 Inhibition in STK11- and KEAP1-Mutant Lung Adenocarcinoma Is Affected by KRAS Mutation Status. J Thorac Oncol. 2022 03; 17(3):399-410.
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Low peripheral blood derived neutrophil-to-lymphocyte ratio (dNLR) is associated with increased tumor T-cell infiltration and favorable outcomes to first-line pembrolizumab in non-small cell lung cancer. J Immunother Cancer. 2021 11; 9(11).
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Tumor Growth Rate After Nadir Is Associated With Survival in Patients With EGFR-Mutant Non-Small-Cell Lung Cancer Treated With Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor. JCO Precis Oncol. 2021 11; 5:1603-1610.
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Diagnosis Please Certificates of Recognition Awarded to Four Individuals and to International and North American Radiology Resident Groups. Radiology. 2021 12; 301(3):497-501.
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Axillary Lymphadenopathy After Coronavirus Disease 2019 Vaccinations in Patients With Thoracic Malignancy: Incidence, Predisposing Factors, and Imaging Characteristics. J Thorac Oncol. 2022 01; 17(1):154-159.
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Prediction Model for Tumor Volume Nadir in EGFR -mutant NSCLC Patients Treated With EGFR Tyrosine Kinase Inhibitors. J Thorac Imaging. 2023 Mar 01; 38(2):82-87.
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SMARCA4 and Other SWItch/Sucrose NonFermentable Family Genomic Alterations in NSCLC: Clinicopathologic Characteristics and Outcomes to Immune Checkpoint Inhibition. J Thorac Oncol. 2021 07; 16(7):1176-1187.
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The Association of Aging Biomarkers, Interstitial Lung Abnormalities, and Mortality. Am J Respir Crit Care Med. 2021 05 01; 203(9):1149-1157.
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Tumor Response Dynamics During First-Line Pembrolizumab Therapy in Patients With Advanced Non-Small-Cell Lung Cancer. JCO Precis Oncol. 2021; 5.
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Progression of traction bronchiectasis/bronchiolectasis in interstitial lung abnormalities is associated with increased all-cause mortality: Age Gene/Environment Susceptibility-Reykjavik Study. Eur J Radiol Open. 2021; 8:100334.
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Early plasma circulating tumor DNA (ctDNA) changes predict response to first-line pembrolizumab-based therapy in non-small cell lung cancer (NSCLC). J Immunother Cancer. 2021 03; 9(3).
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Imaging of Oncologic Treatment-Related Pneumonitis: A Focused Review on Emerging Issues of Immune Checkpoint Inhibitor Pneumonitis, From the AJR Special Series on Inflammation. AJR Am J Roentgenol. 2022 01; 218(1):19-27.
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Interstitial lung abnormalities in patients with stage I non-small cell lung cancer are associated with shorter overall survival: the Boston lung cancer study. Cancer Imaging. 2021 Jan 19; 21(1):14.
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Chest CT Diagnosis and Clinical Management of Drug-Related Pneumonitis in Patients Receiving Molecular Targeting Agents and Immune Checkpoint Inhibitors: A Position Paper From the Fleischner Society. Chest. 2021 03; 159(3):1107-1125.
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Chest CT Diagnosis and Clinical Management of Drug-related Pneumonitis in Patients Receiving Molecular Targeting Agents and Immune Checkpoint Inhibitors: A Position Paper from the Fleischner Society. Radiology. 2021 03; 298(3):550-566.
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Management of Pulmonary Nodules in Oncologic Patients: AJR Expert Panel Narrative Review. AJR Am J Roentgenol. 2021 06; 216(6):1423-1431.
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The associations of interstitial lung abnormalities with cancer diagnoses and mortality. Eur Respir J. 2020 12; 56(6).
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Dynamic Chest X-Ray Using a Flat-Panel Detector System: Technique and Applications. Korean J Radiol. 2021 04; 22(4):634-651.
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Lifestyle and Clinical Risk Factors for Incident Rheumatoid Arthritis-associated Interstitial Lung Disease. J Rheumatol. 2021 05; 48(5):656-663.
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Diagnosis Please Certificates of Recognition Awarded to Five Individuals and to International and North American Radiology Resident Groups. Radiology. 2020 Nov; 297(2):247-250.
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CT Volumetry for Lung-RADS Classification of Solid Nodules. Radiology. 2020 12; 297(3):685-686.
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Projected lung areas using dynamic X-ray (DXR). Eur J Radiol Open. 2020; 7:100263.
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Immune-related adverse events on body CT in patients with small-cell lung cancer treated with immune-checkpoint inhibitors. Eur J Radiol. 2020 Nov; 132:109275.
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Radiomics to Predict Invasiveness of Part-Solid Adenocarcinoma of the Lung. Radiology. 2020 11; 297(2):459-461.
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A Randomized Phase 2 Study of Pembrolizumab With or Without Radiation in Patients With Recurrent or Metastatic Adenoid Cystic Carcinoma. Int J Radiat Oncol Biol Phys. 2021 01 01; 109(1):134-144.
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Incidence of Pseudoprogression during Immune Checkpoint Inhibitor Therapy for Solid Tumors: A Systematic Review and Meta-Analysis. Radiology. 2020 10; 297(1):87-96.
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Outcomes to first-line pembrolizumab in patients with PD-L1-high (=50%) non-small cell lung cancer and a poor performance status. J Immunother Cancer. 2020 08; 8(2).
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Immune-related (IR)-pneumonitis during the COVID-19 pandemic: multidisciplinary recommendations for diagnosis and management. J Immunother Cancer. 2020 06; 8(1).
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Traction Bronchiectasis/Bronchiolectasis is Associated with Interstitial Lung Abnormality Mortality. Eur J Radiol. 2020 Aug; 129:109073.
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Radiographic patterns of symptomatic radiation pneumonitis in lung cancer patients: Imaging predictors for clinical severity and outcome. Lung Cancer. 2020 07; 145:132-139.
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Clinicopathological and genomic correlates of programmed cell death ligand 1 (PD-L1) expression in nonsquamous non-small-cell lung cancer. Ann Oncol. 2020 06; 31(6):807-814.
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Impact of DNA Damage Response and Repair (DDR) Gene Mutations on Efficacy of PD-(L)1 Immune Checkpoint Inhibition in Non-Small Cell Lung Cancer. Clin Cancer Res. 2020 08 01; 26(15):4135-4142.
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Immune-Related Pneumonitis After Chemoradiotherapy and Subsequent Immune Checkpoint Blockade in Unresectable Stage III Non-Small-Cell Lung Cancer. Clin Lung Cancer. 2020 09; 21(5):e435-e444.
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Tumor Volume Analysis as a Predictive Marker for Prolonged Survival in Anaplastic Lymphoma Kinase-rearranged Advanced Non-Small Cell Lung Cancer Patients Treated With Crizotinib. J Thorac Imaging. 2020 Mar; 35(2):101-107.
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Molecular Mechanisms of Acquired Resistance to MET Tyrosine Kinase Inhibitors in Patients with MET Exon 14-Mutant NSCLC. Clin Cancer Res. 2020 06 01; 26(11):2615-2625.
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Tumor volume dynamics and tumor growth rate in ALK-rearranged advanced non-small-cell lung cancer treated with crizotinib. Eur J Radiol Open. 2020; 7:100210.
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Clinical activity of programmed cell death 1 (PD-1) blockade in never, light, and heavy smokers with non-small-cell lung cancer and PD-L1 expression =50. Ann Oncol. 2020 03; 31(3):404-411.
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Overlap of Genetic Risk between Interstitial Lung Abnormalities and Idiopathic Pulmonary Fibrosis. Am J Respir Crit Care Med. 2019 12 01; 200(11):1402-1413.
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Harmonization of Tumor Mutational Burden Quantification and Association With Response to Immune Checkpoint Blockade in Non-Small-Cell Lung Cancer. JCO Precis Oncol. 2019; 3.
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Assessment of Deep Natural Language Processing in Ascertaining Oncologic Outcomes From Radiology Reports. JAMA Oncol. 2019 Oct 01; 5(10):1421-1429.
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Outcomes to first-line pembrolizumab in patients with non-small-cell lung cancer and very high PD-L1 expression. Ann Oncol. 2019 10 01; 30(10):1653-1659.
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Diagnosis Please Certificates of Recognition Awarded to Three Individuals and to International and North American Radiology Resident Groups. Radiology. 2019 11; 293(2):241-244.
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Knowledge Gaps and Research Priorities in Immune Checkpoint Inhibitor-related Pneumonitis. An Official American Thoracic Society Research Statement. Am J Respir Crit Care Med. 2019 09 15; 200(6):e31-e43.
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Imaging of Precision Therapy for Lung Cancer: Current State of the Art. Radiology. 2019 10; 293(1):15-29.
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Rheumatoid Arthritis Disease Activity Predicting Incident Clinically Apparent Rheumatoid Arthritis-Associated Interstitial Lung Disease: A Prospective Cohort Study. Arthritis Rheumatol. 2019 09; 71(9):1472-1482.
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Using CT to Evaluate Visceral Pleural Invasion: Caution Is Advised. Radiology. 2019 Sep; 292(3):750-751.
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Imaging Patterns Are Associated with Interstitial Lung Abnormality Progression and Mortality. Am J Respir Crit Care Med. 2019 07 15; 200(2):175-183.
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Immune Checkpoint Inhibitor Outcomes for Patients With Non-Small-Cell Lung Cancer Receiving Baseline Corticosteroids for Palliative Versus Nonpalliative Indications. J Clin Oncol. 2019 08 01; 37(22):1927-1934.
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Frequency and imaging features of abdominal immune-related adverse events in metastatic lung cancer patients treated with PD-1 inhibitor. Abdom Radiol (NY). 2019 05; 44(5):1917-1927.
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Pneumonitis resulting from radiation and immune checkpoint blockade illustrates characteristic clinical, radiologic and circulating biomarker features. J Immunother Cancer. 2019 04 24; 7(1):112.
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The incidence of ALK inhibitor-related pneumonitis in advanced non-small-cell lung cancer patients: A systematic review and meta-analysis. Lung Cancer. 2019 06; 132:79-86.
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Increased Airway Wall Thickness in Interstitial Lung Abnormalities and Idiopathic Pulmonary Fibrosis. Ann Am Thorac Soc. 2019 04; 16(4):447-454.
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Interstitial lung abnormality in stage IV non-small cell lung cancer: A validation study for the association with poor clinical outcome. Eur J Radiol Open. 2019; 6:128-131.
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Use of targeted next generation sequencing to characterize tumor mutational burden and efficacy of immune checkpoint inhibition in small cell lung cancer. J Immunother Cancer. 2019 03 28; 7(1):87.
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Measurement Variability in Treatment Response Determination for Non-Small Cell Lung Cancer: Improvements Using Radiomics. J Thorac Imaging. 2019 Mar; 34(2):103-115.
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Time-resolved quantitative evaluation of diaphragmatic motion during forced breathing in a health screening cohort in a standing position: Dynamic chest phrenicography. Eur J Radiol. 2019 Apr; 113:59-65.
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M1b Disease in the 8th Edition of TNM Staging of Lung Cancer: Pattern of Single Extrathoracic Metastasis and Clinical Outcome. Oncologist. 2019 08; 24(8):e749-e754.
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Incidental nonneoplastic parenchymal findings in patients undergoing lung resection for mass lesions. Hum Pathol. 2019 04; 86:93-101.
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Decreased and slower diaphragmatic motion during forced breathing in severe COPD patients: Time-resolved quantitative analysis using dynamic chest radiography with a flat panel detector system. Eur J Radiol. 2019 Mar; 112:28-36.
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Perinodular Radiomic Features to Assess Nodule Microenvironment: Does It Help to Distinguish Malignant versus Benign Lung Nodules? Radiology. 2019 Mar; 290(3):793-795.
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Imaging of Histiocytosis in the Era of Genomic Medicine. Radiographics. 2019 Jan-Feb; 39(1):95-114.
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Imaging of Cancer Immunotherapy: Current Approaches and Future Directions. Radiology. 2019 01; 290(1):9-22.
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Reply to the comments on: Pneumonitis in advanced non-small-cell lung cancer patients treated with EGFR tyrosine kinase inhibitor: Meta-analysis of 153 cohorts with 15,713 patients: Meta-analysis of incidence and risk factors of EGFR-TKI pneumonitis in NSCLC. Lung Cancer. 2019 01; 127:168.
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Automated image analysis tool for tumor volume growth rate to guide precision cancer therapy: EGFR-mutant non-small-cell lung cancer as a paradigm. Eur J Radiol. 2018 Dec; 109:68-76.
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PD-L1 expression, tumor mutational burden, and response to immunotherapy in patients with MET exon 14 altered lung cancers. Ann Oncol. 2018 10 01; 29(10):2085-2091.
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Diagnosis Please Certificates of Recognition Awarded to Three Individuals and to International and North American Radiology Resident Groups. Radiology. 2018 11; 289(2):277-279.
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Amplification of Wild-type KRAS Imparts Resistance to Crizotinib in MET Exon 14 Mutant Non-Small Cell Lung Cancer. Clin Cancer Res. 2018 12 01; 24(23):5963-5976.
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Pneumonitis in advanced non-small-cell lung cancer patients treated with EGFR tyrosine kinase inhibitor: Meta-analysis of 153 cohorts with 15,713 patients: Meta-analysis of incidence and risk factors of EGFR-TKI pneumonitis in NSCLC. Lung Cancer. 2018 09; 123:60-69.
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Tumor Response Assessment for Precision Cancer Therapy: Response Evaluation Criteria in Solid Tumors and Beyond. Am Soc Clin Oncol Educ Book. 2018 May 23; 38:1019-1029.
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STK11/LKB1 Mutations and PD-1 Inhibitor Resistance in KRAS-Mutant Lung Adenocarcinoma. Cancer Discov. 2018 07; 8(7):822-835.
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An Acquired NRAS Q61K Mutation in BRAF V600E-Mutant Lung Adenocarcinoma Resistant to Dabrafenib Plus Trametinib. J Thorac Oncol. 2018 08; 13(8):e131-e133.
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Sarcoid-Like Granulomatosis of the Lung Related to Immune-Checkpoint Inhibitors: Distinct Clinical and Imaging Features of a Unique Immune-Related Adverse Event. Cancer Immunol Res. 2018 06; 6(6):630-635.
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Histopathology of Interstitial Lung Abnormalities in the Context of Lung Nodule Resections. Am J Respir Crit Care Med. 2018 04 01; 197(7):955-958.
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Immune-Modified Response Evaluation Criteria In Solid Tumors (imRECIST): Refining Guidelines to Assess the Clinical Benefit of Cancer Immunotherapy. J Clin Oncol. 2018 03 20; 36(9):850-858.
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Radiological features and metastatic patterns of thymic neuroendocrine tumours. Clin Radiol. 2018 05; 73(5):479-484.
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The MUC5B promoter polymorphism is associated with specific interstitial lung abnormality subtypes. Eur Respir J. 2017 09; 50(3).
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Thoracic Complications of Precision Cancer Therapies: A Practical Guide for Radiologists in the New Era of Cancer Care. Radiographics. 2017 Sep-Oct; 37(5):1371-1387.
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Glesatinib Exhibits Antitumor Activity in Lung Cancer Models and Patients Harboring MET Exon 14 Mutations and Overcomes Mutation-mediated Resistance to Type I MET Inhibitors in Nonclinical Models. Clin Cancer Res. 2017 Nov 01; 23(21):6661-6672.
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Tumor Response Dynamics of Advanced Non-small Cell Lung Cancer Patients Treated with PD-1 Inhibitors: Imaging Markers for Treatment Outcome. Clin Cancer Res. 2017 Oct 01; 23(19):5737-5744.
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Monitoring immune-checkpoint blockade: response evaluation and biomarker development. Nat Rev Clin Oncol. 2017 Nov; 14(11):655-668.
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Immune-Related Tumor Response Dynamics in Melanoma Patients Treated with Pembrolizumab: Identifying Markers for Clinical Outcome and Treatment Decisions. Clin Cancer Res. 2017 Aug 15; 23(16):4671-4679.
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Risk of Bias and Heterogeneity-Reply. JAMA Oncol. 2017 06 01; 3(6):858-859.
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Drug-Related Pneumonitis in the Era of Precision Cancer Therapy. JCO Precis Oncol. 2017; 1.
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Osimertinib in EGFR T790M-Positive Lung Cancer. N Engl J Med. 2017 05 18; 376(20):1992-3.
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Pleural abnormalities in the Framingham Heart Study: prevalence and CT image features. Occup Environ Med. 2017 10; 74(10):756-761.
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Headache in the Setting of Immunotherapy Treatment for Metastatic Melanoma. JAMA Oncol. 2017 05 01; 3(5):703-704.
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Difference in the craniocaudal gradient of the maximum pixel value change rate between chronic obstructive pulmonary disease patients and normal subjects using sub-mGy dynamic chest radiography with a flat panel detector system. Eur J Radiol. 2017 Jul; 92:37-44.
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Programmed Death-1/Programmed Death Ligand-1 Inhibitor-Related Pneumonitis and Radiographic Patterns. J Clin Oncol. 2017 05 10; 35(14):1628-1629.
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Immune-Checkpoint Inhibitors in the Era of Precision Medicine: What Radiologists Should Know. Korean J Radiol. 2017 Jan-Feb; 18(1):42-53.
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Interstitial Lung Abnormalities Are Associated with Acute Respiratory Distress Syndrome. Am J Respir Crit Care Med. 2017 01 01; 195(1):138-141.
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Co-clinical quantitative tumor volume imaging in ALK-rearranged NSCLC treated with crizotinib. Eur J Radiol. 2017 Mar; 88:15-20.
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Immune-related response assessment during PD-1 inhibitor therapy in advanced non-small-cell lung cancer patients. J Immunother Cancer. 2016; 4:84.
View in: PubMed

Difference in diaphragmatic motion during tidal breathing in a standing position between COPD patients and normal subjects: Time-resolved quantitative evaluation using dynamic chest radiography with flat panel detector system ("dynamic X-ray phrenicography"). Eur J Radiol. 2017 Feb; 87:76-82.
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Time-Resolved Quantitative Analysis of the Diaphragms During Tidal Breathing in a Standing Position Using Dynamic Chest Radiography with a Flat Panel Detector System ("Dynamic X-Ray Phrenicography"): Initial Experience in 172 Volunteers. Acad Radiol. 2017 04; 24(4):393-400.
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Development and Progression of Interstitial Lung Abnormalities in the Framingham Heart Study. Am J Respir Crit Care Med. 2016 12 15; 194(12):1514-1522.
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Incidence of Programmed Cell Death 1 Inhibitor-Related Pneumonitis in Patients With Advanced Cancer: A Systematic Review and Meta-analysis. JAMA Oncol. 2016 Dec 01; 2(12):1607-1616.
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Institutional implementation of clinical tumor profiling on an unselected cancer population. JCI Insight. 2016 11 17; 1(19):e87062.
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PD-1 inhibitor-related pneumonitis in lymphoma patients treated with single-agent pembrolizumab therapy. Br J Haematol. 2018 03; 180(5):752-755.
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PD-1 Inhibitor-Related Pneumonitis in Advanced Cancer Patients: Radiographic Patterns and Clinical Course. Clin Cancer Res. 2016 Dec 15; 22(24):6051-6060.
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Activity of erlotinib when dosed below the maximum tolerated dose for EGFR-mutant lung cancer: Implications for targeted therapy development. Cancer. 2016 Nov 15; 122(22):3456-3463.
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Pseudoprogression and Measurement Variability. J Clin Oncol. 2016 10 01; 34(28):3480-1.
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Identification of Existing Drugs That Effectively Target NTRK1 and ROS1 Rearrangements in Lung Cancer. Clin Cancer Res. 2017 Jan 01; 23(1):204-213.
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Galectin-3 Is Associated with Restrictive Lung Disease and Interstitial Lung Abnormalities. Am J Respir Crit Care Med. 2016 07 01; 194(1):77-83.
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Immune-related response evaluations during immune-checkpoint inhibitor therapy: establishing a "common language" for the new arena of cancer treatment. J Immunother Cancer. 2016; 4:30.
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Patterns of metastasis and recurrence in thymic epithelial tumours: longitudinal imaging review in correlation with histological subtypes. Clin Radiol. 2016 Oct; 71(10):1010-1017.
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Low dose chest CT protocol (50 mAs) as a routine protocol for comprehensive assessment of intrathoracic abnormality. Eur J Radiol Open. 2016; 3:86-94.
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Standard-dose vs. low-dose CT protocols in the evaluation of localized lung lesions: Capability for lesion characterization-iLEAD study. Eur J Radiol Open. 2016; 3:67-73.
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Association Between Interstitial Lung Abnormalities and All-Cause Mortality. JAMA. 2016 Feb 16; 315(7):672-81.
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Anti-PD-1 Inhibitor-Related Pneumonitis in Non-Small Cell Lung Cancer. Cancer Immunol Res. 2016 Apr; 4(4):289-93.
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Risk of recurrent venous thromboembolism and major hemorrhage in cancer-associated incidental pulmonary embolism among treated and untreated patients: a pooled analysis of 926 patients. J Thromb Haemost. 2016 Jan; 14(1):105-13.
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Volumetric Tumor Response and Progression in EGFR-mutant NSCLC Patients Treated with Erlotinib or Gefitinib. Acad Radiol. 2016 Mar; 23(3):329-36.
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Drug-related pneumonitis during mammalian target of rapamycin inhibitor therapy in patients with neuroendocrine tumors: a radiographic pattern-based approach. Eur J Cancer. 2016 Jan; 53:163-70.
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Clinical Implications of Variant ALK FISH Rearrangement Patterns. J Thorac Oncol. 2015 Nov; 10(11):1648-52.
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Pulmonary cysts identified on chest CT: are they part of aging change or of clinical significance? Thorax. 2015 Dec; 70(12):1156-62.
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A comparison of visual and quantitative methods to identify interstitial lung abnormalities. BMC Pulm Med. 2015 Oct 29; 15:134.
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Drug-Related Pneumonitis During Mammalian Target of Rapamycin Inhibitor Therapy: Radiographic Pattern-Based Approach in Waldenström Macroglobulinemia as a Paradigm. Oncologist. 2015 Sep; 20(9):1077-83.
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Anti-PD-1-Related Pneumonitis during Cancer Immunotherapy. N Engl J Med. 2015 Jul 16; 373(3):288-90.
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Radiographic Profiling of Immune-Related Adverse Events in Advanced Melanoma Patients Treated with Ipilimumab. Cancer Immunol Res. 2015 Oct; 3(10):1185-92.
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Detection of Rheumatoid Arthritis-Interstitial Lung Disease Is Enhanced by Serum Biomarkers. Am J Respir Crit Care Med. 2015 Jun 15; 191(12):1403-12.
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Advanced High-Grade Serous Ovarian Cancer: Frequency and Timing of Thoracic Metastases and the Implications for Chest Imaging Follow-up. Radiology. 2015 Dec; 277(3):733-40.
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Primary Pulmonary NUT Midline Carcinoma: Clinical, Radiographic, and Pathologic Characterizations. J Thorac Oncol. 2015 Jun; 10(6):951-9.
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Hormonal therapy in oncology: a primer for the radiologist. AJR Am J Roentgenol. 2015 Jun; 204(6):W620-30.
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Accuracy and feasibility of estimated tumour volumetry in primary gastric gastrointestinal stromal tumours: validation using semiautomated technique in 127 patients. Eur Radiol. 2016 Jan; 26(1):286-95.
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Single Institution Experience of Ipilimumab 3 mg/kg with Sargramostim (GM-CSF) in Metastatic Melanoma. Cancer Immunol Res. 2015 Sep; 3(9):986-91.
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Normal thymus in adults: appearance on CT and associations with age, sex, BMI and smoking. Eur Radiol. 2016 Jan; 26(1):15-24.
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Delay of treatment change after objective progression on first-line erlotinib in epidermal growth factor receptor-mutant lung cancer. Cancer. 2015 Aug 01; 121(15):2570-7.
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Cancer immunotherapy and immune-related response assessment: The role of radiologists in the new arena of cancer treatment. Eur J Radiol. 2015 Jul; 84(7):1259-68.
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Paraseptal emphysema: Prevalence and distribution on CT and association with interstitial lung abnormalities. Eur J Radiol. 2015 Jul; 84(7):1413-8.
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RECIST 1.1 compared with RECIST 1.0 in patients with advanced renal cell carcinoma receiving vascular endothelial growth factor-targeted therapy. AJR Am J Roentgenol. 2015 Mar; 204(3):W282-8.
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Anti-VEGF molecular targeted therapies in common solid malignancies: comprehensive update for radiologists. Radiographics. 2015 Mar-Apr; 35(2):455-74.
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Interstitial lung abnormalities in treatment-naïve advanced non-small-cell lung cancer patients are associated with shorter survival. Eur J Radiol. 2015 May; 84(5):998-1004.
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Reply to "Usefulness of CT in differentiating lymphoid thymic hyperplasia from true thymic hyperplasia: added value of thymic measurements and CT attenuation". AJR Am J Roentgenol. 2015 Jan; 204(1):W115.
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Biomarkers of rheumatoid arthritis-associated interstitial lung disease. Arthritis Rheumatol. 2015 Jan; 67(1):28-38.
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Anterior Mediastinal Masses in the Framingham Heart Study: Prevalence and CT Image Characteristics. Eur J Radiol Open. 2015; 2:26-31.
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Response assessment in metastatic melanoma treated with ipilimumab and bevacizumab: CT tumor size and density as markers for response and outcome. J Immunother Cancer. 2014; 2(1):40.
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Update on the role of imaging in management of metastatic colorectal cancer. Radiographics. 2014 Nov-Dec; 34(7):1908-28.
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Chemotherapy for locally advanced and metastatic pulmonary carcinoid tumors. Lung Cancer. 2014 Nov; 86(2):241-6.
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Functional impact of a spectrum of interstitial lung abnormalities in rheumatoid arthritis. Chest. 2014 Jul; 146(1):41-50.
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Optimizing immune-related tumor response assessment: does reducing the number of lesions impact response assessment in melanoma patients treated with ipilimumab? J Immunother Cancer. 2014; 2:17.
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Thymic measurements in pathologically proven normal thymus and thymic hyperplasia: intraobserver and interobserver variabilities. Acad Radiol. 2014 Jun; 21(6):733-42.
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Revisiting the relationship between tumour volume and diameter in advanced NSCLC patients: An exercise to maximize the utility of each measure to assess response to therapy. Clin Radiol. 2014 Aug; 69(8):841-8.
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Intrathymic cyst: clinical and radiological features in surgically resected cases. Clin Radiol. 2014 Jul; 69(7):732-8.
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10% Tumor diameter shrinkage on the first follow-up computed tomography predicts clinical outcome in patients with advanced renal cell carcinoma treated with angiogenesis inhibitors: a follow-up validation study. Oncologist. 2014 May; 19(5):507-14.
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State of the art: Response assessment in lung cancer in the era of genomic medicine. Radiology. 2014 Apr; 271(1):6-27.
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Imaging characteristics of pathologically proven thymic hyperplasia: identifying features that can differentiate true from lymphoid hyperplasia. AJR Am J Roentgenol. 2014 Mar; 202(3):471-8.
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Clinical problem solving: utility of sonography in oncologic patients. J Ultrasound Med. 2014 Jan; 33(1):9-22.
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Intraobserver and interobserver variability in computed tomography size and attenuation measurements in patients with renal cell carcinoma receiving antiangiogenic therapy: implications for alternative response criteria. Cancer. 2014 Mar 01; 120(5):711-21.
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Update on the management of gastroenteropancreatic neuroendocrine tumors with emphasis on the role of imaging. AJR Am J Roentgenol. 2013 Oct; 201(4):811-24.
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Volumetric tumor growth in advanced non-small cell lung cancer patients with EGFR mutations during EGFR-tyrosine kinase inhibitor therapy: developing criteria to continue therapy beyond RECIST progression. Cancer. 2013 Nov 01; 119(21):3761-8.
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Tumor volume decrease at 8 weeks is associated with longer survival in EGFR-mutant advanced non-small-cell lung cancer patients treated with EGFR TKI. J Thorac Oncol. 2013 Aug; 8(8):1059-68.
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Intrathoracic malignant peripheral nerve sheath tumors: imaging features and implications for management. Radiol Oncol. 2013; 47(3):230-8.
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Clinical, pathologic, and biologic features associated with BRAF mutations in non-small cell lung cancer. Clin Cancer Res. 2013 Aug 15; 19(16):4532-40.
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RECIST 1.1 in NSCLC patients with EGFR mutations treated with EGFR tyrosine kinase inhibitors: comparison with RECIST 1.0. AJR Am J Roentgenol. 2013 Jul; 201(1):W64-71.
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Developing a common language for tumor response to immunotherapy: immune-related response criteria using unidimensional measurements. Clin Cancer Res. 2013 Jul 15; 19(14):3936-43.
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MUC5B promoter polymorphism and interstitial lung abnormalities. N Engl J Med. 2013 Jun 06; 368(23):2192-200.
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Cancer of unknown primary sites: what radiologists need to know and what oncologists want to know. AJR Am J Roentgenol. 2013 Mar; 200(3):484-92.
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A practical approach to high-resolution CT of diffuse lung disease. Eur J Radiol. 2014 Jan; 83(1):6-19.
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Natural history and molecular characteristics of lung cancers harboring EGFR exon 20 insertions. J Thorac Oncol. 2013 Feb; 8(2):179-84.
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Radiographic assessment and therapeutic decisions at RECIST progression in EGFR-mutant NSCLC treated with EGFR tyrosine kinase inhibitors. Lung Cancer. 2013 Mar; 79(3):283-8.
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Unsuspected pulmonary embolism in lung cancer patients: comparison of clinical characteristics and outcome with suspected pulmonary embolism. Lung Cancer. 2012 Nov; 78(2):161-6.
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Tumoral cavitation in patients with non-small-cell lung cancer treated with antiangiogenic therapy using bevacizumab. Cancer Imaging. 2012 Jun 29; 12:225-35.
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Personalized tumor response assessment in the era of molecular medicine: cancer-specific and therapy-specific response criteria to complement pitfalls of RECIST. AJR Am J Roentgenol. 2012 Apr; 198(4):737-45.
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A murine lung cancer co-clinical trial identifies genetic modifiers of therapeutic response. Nature. 2012 Mar 18; 483(7391):613-7.
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Interstitial lung abnormalities and reduced exercise capacity. Am J Respir Crit Care Med. 2012 Apr 01; 185(7):756-62.
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Statins and pulmonary fibrosis: the potential role of NLRP3 inflammasome activation. Am J Respir Crit Care Med. 2012 Mar 01; 185(5):547-56.
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Lung volumes and emphysema in smokers with interstitial lung abnormalities. N Engl J Med. 2011 Mar 10; 364(10):897-906.
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Incidence of pulmonary embolism in oncologic outpatients at a tertiary cancer center. Cancer. 2011 Aug 15; 117(16):3860-6.
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Imaging of lung cancer in the era of molecular medicine. Acad Radiol. 2011 Apr; 18(4):424-36.
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CT tumor volume measurement in advanced non-small-cell lung cancer: Performance characteristics of an emerging clinical tool. Acad Radiol. 2011 Jan; 18(1):54-62.
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Sonographic features of pectoralis muscle necrosis secondary to gemcitabine-induced radiation recall: case report and review of current literature. J Ultrasound Med. 2010 Oct; 29(10):1499-502.
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New Response Evaluation Criteria in Solid Tumors (RECIST) guidelines for advanced non-small cell lung cancer: comparison with original RECIST and impact on assessment of tumor response to targeted therapy. AJR Am J Roentgenol. 2010 Sep; 195(3):W221-8.
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Revised RECIST guideline version 1.1: What oncologists want to know and what radiologists need to know. AJR Am J Roentgenol. 2010 Aug; 195(2):281-9.
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Case 155: Lane-Hamilton syndrome. Radiology. 2010 Mar; 254(3):985-8.
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Volumetric expiratory HRCT of the lung: clinical applications. Thorac Surg Clin. 2010 Feb; 20(1):121-7, viii-ix.
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Volumetric expiratory HRCT of the lung: clinical applications. Radiol Clin North Am. 2010 Jan; 48(1):177-83.
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The spectrum of pulmonary sarcoidosis: variations of high-resolution CT findings and clues for specific diagnosis. Eur J Radiol. 2010 Jan; 73(1):66-73.
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Cine MR imaging of uterine peristalsis in patients with endometriosis. Eur Radiol. 2007 Jul; 17(7):1813-9.
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3-dimensional adaptive raw-data filter: evaluation in low dose chest multidetector-row computed tomography. J Comput Assist Tomogr. 2006 Nov-Dec; 30(6):933-8.
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Fetal lung volume measurements: determination with MR imaging--effect of various factors. Radiology. 2006 Jul; 240(1):187-93.
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Excessive collapsibility of bronchi in bronchiectasis: evaluation on volumetric expiratory high-resolution CT. J Comput Assist Tomogr. 2006 May-Jun; 30(3):474-8.
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Loss of anteroposterior intralobar attenuation gradient of the lung: Correlation with pulmonary function. Acad Radiol. 2006 May; 13(5):589-97.
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Incidence of pulmonary embolism in younger versus older patients using CT. J Thorac Imaging. 2006 May; 21(2):167-71.
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Coronal reformations of the chest on 64-row multi-detector row CT: evaluation of image quality in comparison with 16-, 8- and 4-row multi-detector row CT. Eur J Radiol. 2006 Aug; 59(2):231-7.
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The thymus: a comprehensive review. Radiographics. 2006 Mar-Apr; 26(2):335-48.
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Evaluation of pulmonary embolisms using coronal reformations on 64-row multidetector-row computed tomography: Comparison with axial images. J Comput Assist Tomogr. 2006 Mar-Apr; 30(2):233-7.
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Evaluation of thoracic abnormalities on 64-row multi-detector row CT: comparison between axial images versus coronal reformations. Eur J Radiol. 2006 Jul; 59(1):33-41.
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Benign or malignant?: differentiating breast lesions with computed tomography attenuation values on dynamic computed tomography mammography. J Comput Assist Tomogr. 2005 Nov-Dec; 29(6):772-9.
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Volumetric expiratory HRCT imaging with MSCT. J Thorac Imaging. 2005 Aug; 20(3):176-85.
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Effects of oral 5-fluorouracil drugs on hepatic fat content in patients with colon cancer. Acad Radiol. 2005 Jun; 12(6):722-7.
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Bronchomalacia in sarcoidosis: evaluation on volumetric expiratory high-resolution CT of the lung. Acad Radiol. 2005 May; 12(5):596-601.
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Comparison of artifacts on coronal reformation and axial CT pulmonary angiography images using single-detector and 4- and 8-detector multidetector-row helical CT scanners. Acad Radiol. 2005 May; 12(5):602-7.
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Tracheobronchomalacia: comparison between end-expiratory and dynamic expiratory CT for evaluation of central airway collapse. Radiology. 2005 May; 235(2):635-41.
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A simple method for displaying cine images on web-based teaching files. AJR Am J Roentgenol. 2005 Feb; 184(2):691-4.
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Functional evaluation of the postoperative gastrointestinal tract using kinematic MR imaging: Quantitative assessment of peristaltic activity. Eur J Radiol. 2005 Feb; 53(2):263-7.
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Uterine contractions evaluated on cine MR imaging in patients with uterine leiomyomas. Eur J Radiol. 2005 Jan; 53(1):142-6.
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Volumetric expiratory high-resolution CT of the lung. Eur J Radiol. 2004 Nov; 52(2):180-4.
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Sagittal reformations of volumetric inspiratory and expiratory high-resolution CT of the lung. Acad Radiol. 2004 Nov; 11(11):1282-90.
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Architecture of the lung: morphology and function. J Thorac Imaging. 2004 Oct; 19(4):221-7.
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Comprehensive innovative solution for resident education using the Intranet Journal of Chest Radiology. Acad Radiol. 2004 Oct; 11(10):1149-52.
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Use of personal digital assistants in diagnostic radiology resident education. Acad Radiol. 2004 Oct; 11(10):1153-8.
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MR imaging of ovarian hemorrhage. Eur J Radiol. 2004 Jul; 51(1):34-40.
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A mobile solution: PDA-based platform for radiology information management. AJR Am J Roentgenol. 2004 Jul; 183(1):237-42.
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Coronal reformations of volumetric expiratory high-resolution CT of the lung. AJR Am J Roentgenol. 2004 Apr; 182(4):979-82.
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Value of volumetric data acquisition in expiratory high-resolution computed tomography of the lung. J Comput Assist Tomogr. 2004 Mar-Apr; 28(2):209-14.
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Endovascular papillary angioendothelioma (Dabska tumor) of bone. Orthopedics. 2004 Mar; 27(3):327-8.
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Multiple enhancing lesions detected on dynamic helical computed tomography-mammography. J Comput Assist Tomogr. 2003 Sep-Oct; 27(5):771-8.
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Magnetic resonance imaging findings in gynecologic emergencies. J Comput Assist Tomogr. 2003 Jul-Aug; 27(4):564-70.
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Primary retroperitoneal neoplasms: CT and MR imaging findings with anatomic and pathologic diagnostic clues. Radiographics. 2003 Jan-Feb; 23(1):45-57.
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Journal of Women’s Imaging. MR Appearance of the Mature Cystic Teratoma of the Ovary with Malignant Transformation to Spindle Cell Carcinoma. 2003; (5):83-86.

Head and neck tuberculosis. Clinical Imagiology. 2003; (19):508-515. Review (in Japanese)..

Effects of tamoxifen on hepatic fat content and the development of hepatic steatosis in patients with breast cancer: high frequency of involvement and rapid reversal after completion of tamoxifen therapy. AJR Am J Roentgenol. 2003 Jan; 180(1):129-34.
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MRI of early unruptured ectopic pregnancy: detection of gestational sac. J Comput Assist Tomogr. 2002 Jan-Feb; 26(1):134-7.
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