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Mizuki Nishino, MD, MPH


Radiology

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Physician

  • Physician
  • Associate Professor of Radiology, Harvard Medical School

Centers/Programs

Clinical Interests

  • Oncologic imaging
  • Thoracic imaging

Contact Information

  • Office Phone Number617-632-2595
  • Fax617-582-8574

Board Certification:

  • Diagnostic Radiology, 2008

Fellowship:

  • Beth Israel Deaconess Medical Center, Thoracic Imaging

Residency:

  • Beth Israel Deaconess Medical Center, Diagnostic Radiology

Medical School:

  • Kyoto University Faculty of Medicine, Japan

Recent Awards:

  • R01 award from the National Cancer Institute (PI: Nishino, 1R01CA203636, 2017-2021) “Automated in vivo analysis of tumor growth rate as a guide for therapeutic decisions to advance personalized cancer treatment” 2017
  • Magna Cum Laude- Dynamic Chest Radiography Using Flat Panel Detector System: Technique and Application. RSNA 2016, Chicago, IL, Nov 2016
  • Cum Laude- Thoracic Complications of Precision Cancer Therapies: A Practical Guide for Radiologists in the New Era of Cancer Care. RSNA 2016, Chicago, IL, Nov 2016
  • Merck Investigator Studies Program (PI: Nishino, 2016-2018). “Quantitative imaging analysis during pembrolizumab therapy in advanced melanoma patients: providing an objective marker for survival and therapeutic decisions” 2016
  • Editors' Recognition Award for Distinction in Reviewing, Journal of Thoracic Imaging. 2014, 2015
  • Diagnosis Please Award for Cases 205-216 published in 2014. Announcement in: Radiology. 2015; 277: 314-7. 2014
  • Diagnosis Please Award for Cases 181-192 published in 2012. Announcement in: Radiology. 2013; 269: 627-31. 2012
  • Dana-Farber Cancer Institute Fellowship for the Eleanor and Miles Shore 50th Anniversary Fellowship Program. (PI: Nishino, 2012) “Quantification of Apoptotic Activity in Non-small-cell Lung Cancer treated with Targeted Therapy: A pilot study.” 2012
  • K 23 Award from the National Cancer Institute (5K23CA157631, PI: Nishino, 2011-2016) “CT Volume Measurement of Lung Cancer treated with Erlotinib: Genomic Correlation” 2011
  • RSNA Research Scholar Grant, RSNA R&E Foundation (PI: Nishino, 2009-2011) "Chronological Analysis of Tumor Size, Volume and CT attenuation coefficient in Women with Adenocarcinoma of the Lung Treated with Erlotinib" 2009

Research

Nishino M, Sholl LM, Awad MM, Hatabu H, Armand P, Hodi FS. Sarcoid-Like Granulomatosis of the Lung Related to Immune-Checkpoint Inhibitors: Distinct Clinical and Imaging Features of a Unique Immune-Related Adverse Event. Cancer Immunol Res. 2018 Jun; 6(6):630-635.
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Miller ER, Putman RK, Vivero M, Hung Y, Araki T, Nishino M, Washko GR, Rosas IO, Hatabu H, Sholl LM, Hunninghake GM. Histopathology of Interstitial Lung Abnormalities in the Context of Lung Nodule Resections. Am J Respir Crit Care Med. 2018 Apr 01; 197(7):955-958.
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Putman RK, Gudmundsson G, Araki T, Nishino M, Sigurdsson S, Gudmundsson EF, Eiríksdottír G, Aspelund T, Ross JC, San José Estépar R, Miller ER, Yamada Y, Yanagawa M, Tomiyama N, Launer LJ, Harris TB, El-Chemaly S, Raby BA, Cho MH, Rosas IO, Washko GR, Schwartz DA, Silverman EK, Gudnason V, Hatabu H, Hunninghake GM. The MUC5B promoter polymorphism is associated with specific interstitial lung abnormality subtypes. Eur Respir J. 2017 Sep; 50(3).
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Nishino M, Hatabu H, Sholl LM, Ramaiya NH. Thoracic Complications of Precision Cancer Therapies: A Practical Guide for Radiologists in the New Era of Cancer Care. Radiographics. 2017 Sep-Oct; 37(5):1371-1387.
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Nishino M, Dahlberg SE, Adeni AE, Lydon CA, Hatabu H, Jänne PA, Hodi FS, Awad MM. Tumor Response Dynamics of Advanced Non-small Cell Lung Cancer Patients Treated with PD-1 Inhibitors: Imaging Markers for Treatment Outcome. Clin Cancer Res. 2017 Oct 01; 23(19):5737-5744.
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Nishino M, Ramaiya NH, Hatabu H, Hodi FS. Monitoring immune-checkpoint blockade: response evaluation and biomarker development. Nat Rev Clin Oncol. 2017 Nov; 14(11):655-668.
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Nishino M, Giobbie-Hurder A, Manos MP, Bailey N, Buchbinder EI, Ott PA, Ramaiya NH, Hodi FS. Immune-Related Tumor Response Dynamics in Melanoma Patients Treated with Pembrolizumab: Identifying Markers for Clinical Outcome and Treatment Decisions. Clin Cancer Res. 2017 Aug 15; 23(16):4671-4679.
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Nishino M, Giobbie-Hurder A, Hodi FS. Risk of Bias and Heterogeneity-Reply. JAMA Oncol. 2017 Jun 01; 3(6):858-859.
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Nishino M, Hatabu H. Osimertinib in EGFR T790M-Positive Lung Cancer. N Engl J Med. 2017 05 18; 376(20):1992-3.
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Araki T, Yanagawa M, Sun FJ, Dupuis J, Nishino M, Yamada Y, Washko GR, Christiani DC, Tomiyama N, O'Connor GT, Hunninghake GM, Hatabu H. Pleural abnormalities in the Framingham Heart Study: prevalence and CT image features. Occup Environ Med. 2017 Oct; 74(10):756-761.
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Comstock DE, Nishino M, Giardino AA. Headache in the Setting of Immunotherapy Treatment for Metastatic Melanoma. JAMA Oncol. 2017 May 01; 3(5):703-704.
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Yamada Y, Ueyama M, Abe T, Araki T, Abe T, Nishino M, Jinzaki M, Hatabu H, Kudoh S. Difference in the craniocaudal gradient of the maximum pixel value change rate between chronic obstructive pulmonary disease patients and normal subjects using sub-mGy dynamic chest radiography with a flat panel detector system. Eur J Radiol. 2017 Jul; 92:37-44.
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Nishino M, Hatabu H. Programmed Death-1/Programmed Death Ligand-1 Inhibitor-Related Pneumonitis and Radiographic Patterns. J Clin Oncol. 2017 May 10; 35(14):1628-1629.
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Braschi-Amirfarzan M, Tirumani SH, Hodi FS, Nishino M. Immune-Checkpoint Inhibitors in the Era of Precision Medicine: What Radiologists Should Know. Korean J Radiol. 2017 Jan-Feb; 18(1):42-53.
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Putman RK, Hunninghake GM, Dieffenbach PB, Barragan-Bradford D, Serhan K, Adams U, Hatabu H, Nishino M, Padera RF, Fredenburgh LE, Baron RM, Englert JA. Interstitial Lung Abnormalities Are Associated with Acute Respiratory Distress Syndrome. Am J Respir Crit Care Med. 2017 01 01; 195(1):138-141.
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Nishino M, Sacher AG, Gandhi L, Chen Z, Akbay E, Fedorov A, Westin CF, Hatabu H, Johnson BE, Hammerman P, Wong KK. Co-clinical quantitative tumor volume imaging in ALK-rearranged NSCLC treated with crizotinib. Eur J Radiol. 2017 Mar; 88:15-20.
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Nishino M, Ramaiya NH, Chambers ES, Adeni AE, Hatabu H, Jänne PA, Hodi FS, Awad MM. Immune-related response assessment during PD-1 inhibitor therapy in advanced non-small-cell lung cancer patients. J Immunother Cancer. 2016; 4:84.
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Yamada Y, Ueyama M, Abe T, Araki T, Abe T, Nishino M, Jinzaki M, Hatabu H, Kudoh S. Difference in diaphragmatic motion during tidal breathing in a standing position between COPD patients and normal subjects: Time-resolved quantitative evaluation using dynamic chest radiography with flat panel detector system ("dynamic X-ray phrenicography"). Eur J Radiol. 2017 Feb; 87:76-82.
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Yamada Y, Ueyama M, Abe T, Araki T, Abe T, Nishino M, Jinzaki M, Hatabu H, Kudoh S. Time-Resolved Quantitative Analysis of the Diaphragms During Tidal Breathing in a Standing Position Using Dynamic Chest Radiography with a Flat Panel Detector System ("Dynamic X-Ray Phrenicography"): Initial Experience in 172 Volunteers. Acad Radiol. 2017 Apr; 24(4):393-400.
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Araki T, Putman RK, Hatabu H, Gao W, Dupuis J, Latourelle JC, Nishino M, Zazueta OE, Kurugol S, Ross JC, San José Estépar R, Schwartz DA, Rosas IO, Washko GR, O'Connor GT, Hunninghake GM. Development and Progression of Interstitial Lung Abnormalities in the Framingham Heart Study. Am J Respir Crit Care Med. 2016 12 15; 194(12):1514-1522.
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Nishino M, Giobbie-Hurder A, Hatabu H, Ramaiya NH, Hodi FS. Incidence of Programmed Cell Death 1 Inhibitor-Related Pneumonitis in Patients With Advanced Cancer: A Systematic Review and Meta-analysis. JAMA Oncol. 2016 Dec 01; 2(12):1607-1616.
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Nishino M, Ramaiya NH, Hatabu H, Hodi FS, Armand PF. PD-1 inhibitor-related pneumonitis in lymphoma patients treated with single-agent pembrolizumab therapy. Br J Haematol. 2018 Mar; 180(5):752-755.
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Nishino M, Ramaiya NH, Awad MM, Sholl LM, Maattala JA, Taibi M, Hatabu H, Ott PA, Armand PF, Hodi FS. PD-1 Inhibitor-Related Pneumonitis in Advanced Cancer Patients: Radiographic Patterns and Clinical Course. Clin Cancer Res. 2016 Dec 15; 22(24):6051-6060.
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Lampson BL, Nishino M, Dahlberg SE, Paul D, Santos AA, Jänne PA, Oxnard GR. Activity of erlotinib when dosed below the maximum tolerated dose for EGFR-mutant lung cancer: Implications for targeted therapy development. Cancer. 2016 Aug 15.
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Nishino M. Pseudoprogression and Measurement Variability. J Clin Oncol. 2016 10 01; 34(28):3480-1.
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Ho JE, Gao W, Levy D, Santhanakrishnan R, Araki T, Rosas IO, Hatabu H, Latourelle JC, Nishino M, Dupuis J, Washko GR, O'Connor GT, Hunninghake GM. Galectin-3 Is Associated with Restrictive Lung Disease and Interstitial Lung Abnormalities. Am J Respir Crit Care Med. 2016 07 01; 194(1):77-83.
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Chong CR, Bahcall M, Capelletti M, Kosaka T, Ercan D, Sim T, Sholl LM, Nishino M, Johnson BE, Gray NS, Jänne PA. Identification of Existing Drugs That Effectively Target NTRK1 and ROS1 Rearrangements in Lung Cancer. Clin Cancer Res. 2017 Jan 01; 23(1):204-213.
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Nishino M. Immune-related response evaluations during immune-checkpoint inhibitor therapy: establishing a "common language" for the new arena of cancer treatment. J Immunother Cancer. 2016; 4:30.
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Khandelwal A, Sholl LM, Araki T, Ramaiya NH, Hatabu H, Nishino M. Patterns of metastasis and recurrence in thymic epithelial tumours: longitudinal imaging review in correlation with histological subtypes. Clin Radiol. 2016 Oct; 71(10):1010-7.
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Kubo T, Ohno Y, Nishino M, Lin PJ, Gautam S, Kauczor HU, Hatabu H. Low dose chest CT protocol (50 mAs) as a routine protocol for comprehensive assessment of intrathoracic abnormality. Eur J Radiol Open. 2016; 3:86-94.
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Putman RK, Hatabu H, Araki T, Gudmundsson G, Gao W, Nishino M, Okajima Y, Dupuis J, Latourelle JC, Cho MH, El-Chemaly S, Coxson HO, Celli BR, Fernandez IE, Zazueta OE, Ross JC, Harmouche R, Estépar RS, Diaz AA, Sigurdsson S, Gudmundsson EF, Eiríksdottír G, Aspelund T, Budoff MJ, Kinney GL, Hokanson JE, Williams MC, Murchison JT, MacNee W, Hoffmann U, O'Donnell CJ, Launer LJ, Harrris TB, Gudnason V, Silverman EK, O'Connor GT, Washko GR, Rosas IO, Hunninghake GM. Association Between Interstitial Lung Abnormalities and All-Cause Mortality. JAMA. 2016 Feb 16; 315(7):672-81.
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Nishino M, Chambers ES, Chong CR, Ramaiya NH, Gray SW, Marcoux JP, Hatabu H, Jänne PA, Hodi FS, Awad MM. Anti-PD-1 Inhibitor-Related Pneumonitis in Non-Small Cell Lung Cancer. Cancer Immunol Res. 2016 Apr; 4(4):289-93.
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van der Hulle T, den Exter PL, Planquette B, Meyer G, Soler S, Monreal M, Jiménez D, Portillo AK, O'Connell C, Liebman HA, Shteinberg M, Adir Y, Tiseo M, Bersanelli M, Abdel-Razeq HN, Mansour AH, Donnelly OG, Radhakrishna G, Ramasamy S, Bozas G, Maraveyas A, Shinagare AB, Hatabu H, Nishino M, Huisman MV, Klok FA. Risk of recurrent venous thromboembolism and major hemorrhage in cancer-associated incidental pulmonary embolism among treated and untreated patients: a pooled analysis of 926 patients. J Thromb Haemost. 2016 Jan; 14(1):105-13.
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Nishino M, Dahlberg SE, Fulton LE, Digumarthy SR, Hatabu H, Johnson BE, Sequist LV. Volumetric Tumor Response and Progression in EGFR-mutant NSCLC Patients Treated with Erlotinib or Gefitinib. Acad Radiol. 2016 Mar; 23(3):329-36.
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Nishino M, Brais LK, Brooks NV, Hatabu H, Kulke MH, Ramaiya NH. Drug-related pneumonitis during mammalian target of rapamycin inhibitor therapy in patients with neuroendocrine tumors: a radiographic pattern-based approach. Eur J Cancer. 2016 Jan; 53:163-70.
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Gao X, Sholl LM, Nishino M, Heng JC, Jänne PA, Oxnard GR. Clinical Implications of Variant ALK FISH Rearrangement Patterns. J Thorac Oncol. 2015 Nov; 10(11):1648-52.
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Kliment CR, Araki T, Doyle TJ, Gao W, Dupuis J, Latourelle JC, Zazueta OE, Fernandez IE, Nishino M, Okajima Y, Ross JC, Estépar RS, Diaz AA, Lederer DJ, Schwartz DA, Silverman EK, Rosas IO, Washko GR, O'Connor GT, Hatabu H, Hunninghake GM. A comparison of visual and quantitative methods to identify interstitial lung abnormalities. BMC Pulm Med. 2015 Oct 29; 15:134.
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Araki T, Nishino M, Gao W, Dupuis J, Putman RK, Washko GR, Hunninghake GM, O'Connor GT, Hatabu H. Pulmonary cysts identified on chest CT: are they part of aging change or of clinical significance? Thorax. 2015 Dec; 70(12):1156-62.
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Nishino M, Boswell EN, Hatabu H, Ghobrial IM, Ramaiya NH. Drug-Related Pneumonitis During Mammalian Target of Rapamycin Inhibitor Therapy: Radiographic Pattern-Based Approach in Waldenström Macroglobulinemia as a Paradigm. Oncologist. 2015 Sep; 20(9):1077-83.
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Nishino M, Sholl LM, Hodi FS, Hatabu H, Ramaiya NH. Anti-PD-1-Related Pneumonitis during Cancer Immunotherapy. N Engl J Med. 2015 Jul 16; 373(3):288-90.
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Tirumani SH, Ramaiya NH, Keraliya A, Bailey ND, Ott PA, Hodi FS, Nishino M. Radiographic Profiling of Immune-Related Adverse Events in Advanced Melanoma Patients Treated with Ipilimumab. Cancer Immunol Res. 2015 Oct; 3(10):1185-92.
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Doyle TJ, Patel AS, Hatabu H, Nishino M, Wu G, Osorio JC, Golzarri MF, Traslosheros A, Chu SG, Frits ML, Iannaccone CK, Koontz D, Fuhrman C, Weinblatt ME, El-Chemaly SY, Washko GR, Hunninghake GM, Choi AM, Dellaripa PF, Oddis CV, Shadick NA, Ascherman DP, Rosas IO. Detection of Rheumatoid Arthritis-Interstitial Lung Disease Is Enhanced by Serum Biomarkers. Am J Respir Crit Care Med. 2015 Jun 15; 191(12):1403-12.
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Shinagare AB, O'Neill AC, Cheng S, Somarouthu B, Tirumani SH, Nishino M, Van den Abbeele AD, Ramaiya NH. Advanced High-Grade Serous Ovarian Cancer: Frequency and Timing of Thoracic Metastases and the Implications for Chest Imaging Follow-up. Radiology. 2015 Dec; 277(3):733-40.
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Sholl LM, Nishino M, Pokharel S, Mino-Kenudson M, French CA, Janne PA, Lathan C. Primary Pulmonary NUT Midline Carcinoma: Clinical, Radiographic, and Pathologic Characterizations. J Thorac Oncol. 2015 Jun; 10(6):951-9.
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Fairchild A, Tirumani SH, Rosenthal MH, Howard SA, Krajewski KM, Nishino M, Shinagare AB, Jagannathan JP, Ramaiya NH. Hormonal therapy in oncology: a primer for the radiologist. AJR Am J Roentgenol. 2015 Jun; 204(6):W620-30.
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Tirumani SH, Shinagare AB, O'Neill AC, Nishino M, Rosenthal MH, Ramaiya NH. Accuracy and feasibility of estimated tumour volumetry in primary gastric gastrointestinal stromal tumours: validation using semiautomated technique in 127 patients. Eur Radiol. 2016 Jan; 26(1):286-95.
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Luke JJ, Donahue H, Nishino M, Giobbie-Hurder A, Davis M, Bailey N, Ott PA, Hodi FS. Single Institution Experience of Ipilimumab 3 mg/kg with Sargramostim (GM-CSF) in Metastatic Melanoma. Cancer Immunol Res. 2015 Sep; 3(9):986-91.
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Araki T, Nishino M, Gao W, Dupuis J, Hunninghake GM, Murakami T, Washko GR, O'Connor GT, Hatabu H. Normal thymus in adults: appearance on CT and associations with age, sex, BMI and smoking. Eur Radiol. 2016 Jan; 26(1):15-24.
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Lo PC, Dahlberg SE, Nishino M, Johnson BE, Sequist LV, Jackman DM, Jänne PA, Oxnard GR. Delay of treatment change after objective progression on first-line erlotinib in epidermal growth factor receptor-mutant lung cancer. Cancer. 2015 Aug 01; 121(15):2570-7.
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Nishino M, Tirumani SH, Ramaiya NH, Hodi FS. Cancer immunotherapy and immune-related response assessment: The role of radiologists in the new arena of cancer treatment. Eur J Radiol. 2015 Jul; 84(7):1259-68.
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Araki T, Nishino M, Zazueta OE, Gao W, Dupuis J, Okajima Y, Latourelle JC, Rosas IO, Murakami T, O'Connor GT, Washko GR, Hunninghake GM, Hatabu H. Paraseptal emphysema: Prevalence and distribution on CT and association with interstitial lung abnormalities. Eur J Radiol. 2015 Jul; 84(7):1413-8.
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Krajewski KM, Nishino M, Ramaiya NH, Choueiri TK. RECIST 1.1 compared with RECIST 1.0 in patients with advanced renal cell carcinoma receiving vascular endothelial growth factor-targeted therapy. AJR Am J Roentgenol. 2015 Mar; 204(3):W282-8.
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Tirumani SH, Fairchild A, Krajewski KM, Nishino M, Howard SA, Baheti AD, Rosenthal MH, Jagannathan JP, Shinagare AB, Ramaiya NH. Anti-VEGF molecular targeted therapies in common solid malignancies: comprehensive update for radiologists. Radiographics. 2015 Mar-Apr; 35(2):455-74.
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Nishino M, Cardarella S, Dahlberg SE, Araki T, Lydon C, Jackman DM, Rabin MS, Hatabu H, Johnson BE. Interstitial lung abnormalities in treatment-naïve advanced non-small-cell lung cancer patients are associated with shorter survival. Eur J Radiol. 2015 May; 84(5):998-1004.
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Araki T, Nishino M, Gao W, Dupuis J, Washko GR, Hunninghake GM, Murakami T, O'Connor GT, Hatabu H. Anterior Mediastinal Masses in the Framingham Heart Study: Prevalence and CT Image Characteristics. Eur J Radiol Open. 2015; 2:26-31.
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Nishino M, Araki T, Sholl LM. Reply to "Usefulness of CT in differentiating lymphoid thymic hyperplasia from true thymic hyperplasia: added value of thymic measurements and CT attenuation". AJR Am J Roentgenol. 2015 Jan; 204(1):W115.
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Chen J, Doyle TJ, Liu Y, Aggarwal R, Wang X, Shi Y, Ge SX, Huang H, Lin Q, Liu W, Cai Y, Koontz D, Fuhrman CR, Golzarri MF, Liu Y, Hatabu H, Nishino M, Araki T, Dellaripa PF, Oddis CV, Rosas IO, Ascherman DP. Biomarkers of rheumatoid arthritis-associated interstitial lung disease. Arthritis Rheumatol. 2015 Jan; 67(1):28-38.
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Nishino M, Giobbie-Hurder A, Ramaiya NH, Hodi FS. Response assessment in metastatic melanoma treated with ipilimumab and bevacizumab: CT tumor size and density as markers for response and outcome. J Immunother Cancer. 2014; 2(1):40.
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Tirumani SH, Kim KW, Nishino M, Howard SA, Krajewski KM, Jagannathan JP, Cleary JM, Ramaiya NH, Shinagare AB. Update on the role of imaging in management of metastatic colorectal cancer. Radiographics. 2014 Nov-Dec; 34(7):1908-28.
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Chong CR, Wirth LJ, Nishino M, Chen AB, Sholl LM, Kulke MH, McNamee CJ, Jänne PA, Johnson BE. Chemotherapy for locally advanced and metastatic pulmonary carcinoid tumors. Lung Cancer. 2014 Nov; 86(2):241-6.
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Doyle TJ, Dellaripa PF, Batra K, Frits ML, Iannaccone CK, Hatabu H, Nishino M, Weinblatt ME, Ascherman DP, Washko GR, Hunninghake GM, Choi AMK, Shadick NA, Rosas IO. Functional impact of a spectrum of interstitial lung abnormalities in rheumatoid arthritis. Chest. 2014 Jul; 146(1):41-50.
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Nishino M, Gargano M, Suda M, Ramaiya NH, Hodi FS. Optimizing immune-related tumor response assessment: does reducing the number of lesions impact response assessment in melanoma patients treated with ipilimumab? J Immunother Cancer. 2014; 2:17.
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Araki T, Sholl LM, Gerbaudo VH, Hatabu H, Nishino M. Thymic measurements in pathologically proven normal thymus and thymic hyperplasia: intraobserver and interobserver variabilities. Acad Radiol. 2014 Jun; 21(6):733-42.
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Nishino M, Jackman DM, DiPiro PJ, Hatabu H, Jänne PA, Johnson BE. Revisiting the relationship between tumour volume and diameter in advanced NSCLC patients: An exercise to maximize the utility of each measure to assess response to therapy. Clin Radiol. 2014 Aug; 69(8):841-8.
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Araki T, Sholl LM, Gerbaudo VH, Hatabu H, Nishino M. Intrathymic cyst: clinical and radiological features in surgically resected cases. Clin Radiol. 2014 Jul; 69(7):732-8.
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Krajewski KM, Franchetti Y, Nishino M, Fay AP, Ramaiya N, Van den Abbeele AD, Choueiri TK. 10% Tumor diameter shrinkage on the first follow-up computed tomography predicts clinical outcome in patients with advanced renal cell carcinoma treated with angiogenesis inhibitors: a follow-up validation study. Oncologist. 2014 May; 19(5):507-14.
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Nishino M, Hatabu H, Johnson BE, McLoud TC. State of the art: Response assessment in lung cancer in the era of genomic medicine. Radiology. 2014 Apr; 271(1):6-27.
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Araki T, Sholl LM, Gerbaudo VH, Hatabu H, Nishino M. Imaging characteristics of pathologically proven thymic hyperplasia: identifying features that can differentiate true from lymphoid hyperplasia. AJR Am J Roentgenol. 2014 Mar; 202(3):471-8.
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Cooley C, Nishino M, Jagannathan J, Ramaiya N, Di Salvo D, Krajewski KM. Clinical problem solving: utility of sonography in oncologic patients. J Ultrasound Med. 2014 Jan; 33(1):9-22.
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Krajewski KM, Nishino M, Franchetti Y, Ramaiya NH, Van den Abbeele AD, Choueiri TK. Intraobserver and interobserver variability in computed tomography size and attenuation measurements in patients with renal cell carcinoma receiving antiangiogenic therapy: implications for alternative response criteria. Cancer. 2014 Mar 01; 120(5):711-21.
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Kim KW, Krajewski KM, Nishino M, Jagannathan JP, Shinagare AB, Tirumani SH, Ramaiya NH. Update on the management of gastroenteropancreatic neuroendocrine tumors with emphasis on the role of imaging. AJR Am J Roentgenol. 2013 Oct; 201(4):811-24.
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Nishino M, Dahlberg SE, Cardarella S, Jackman DM, Rabin MS, Ramaiya NH, Hatabu H, Jänne PA, Johnson BE. Volumetric tumor growth in advanced non-small cell lung cancer patients with EGFR mutations during EGFR-tyrosine kinase inhibitor therapy: developing criteria to continue therapy beyond RECIST progression. Cancer. 2013 Nov 01; 119(21):3761-8.
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Nishino M, Dahlberg SE, Cardarella S, Jackman DM, Rabin MS, Hatabu H, Jänne PA, Johnson BE. Tumor volume decrease at 8 weeks is associated with longer survival in EGFR-mutant advanced non-small-cell lung cancer patients treated with EGFR TKI. J Thorac Oncol. 2013 Aug; 8(8):1059-68.
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Kamran SC, Shinagare AB, Howard SA, Nishino M, Hornick JL, Krajewski KM, Ramaiya NH. Intrathoracic malignant peripheral nerve sheath tumors: imaging features and implications for management. Radiol Oncol. 2013; 47(3):230-8.
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Cardarella S, Ogino A, Nishino M, Butaney M, Shen J, Lydon C, Yeap BY, Sholl LM, Johnson BE, Jänne PA. Clinical, pathologic, and biologic features associated with BRAF mutations in non-small cell lung cancer. Clin Cancer Res. 2013 Aug 15; 19(16):4532-40.
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Nishino M, Cardarella S, Jackman DM, Ramaiya NH, Rabin MS, Hatabu H, Jänne PA, Johnson BE. RECIST 1.1 in NSCLC patients with EGFR mutations treated with EGFR tyrosine kinase inhibitors: comparison with RECIST 1.0. AJR Am J Roentgenol. 2013 Jul; 201(1):W64-71.
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Nishino M, Giobbie-Hurder A, Gargano M, Suda M, Ramaiya NH, Hodi FS. Developing a common language for tumor response to immunotherapy: immune-related response criteria using unidimensional measurements. Clin Cancer Res. 2013 Jul 15; 19(14):3936-43.
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Hunninghake GM, Hatabu H, Okajima Y, Gao W, Dupuis J, Latourelle JC, Nishino M, Araki T, Zazueta OE, Kurugol S, Ross JC, San José Estépar R, Murphy E, Steele MP, Loyd JE, Schwarz MI, Fingerlin TE, Rosas IO, Washko GR, O'Connor GT, Schwartz DA. MUC5B promoter polymorphism and interstitial lung abnormalities. N Engl J Med. 2013 Jun 06; 368(23):2192-200.
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Kim KW, Krajewski KM, Jagannathan JP, Nishino M, Shinagare AB, Hornick JL, Ramaiya NH. Cancer of unknown primary sites: what radiologists need to know and what oncologists want to know. AJR Am J Roentgenol. 2013 Mar; 200(3):484-92.
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Nishino M, Itoh H, Hatabu H. A practical approach to high-resolution CT of diffuse lung disease. Eur J Radiol. 2014 Jan; 83(1):6-19.
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Oxnard GR, Lo PC, Nishino M, Dahlberg SE, Lindeman NI, Butaney M, Jackman DM, Johnson BE, Jänne PA. Natural history and molecular characteristics of lung cancers harboring EGFR exon 20 insertions. J Thorac Oncol. 2013 Feb; 8(2):179-84.
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Nishino M, Cardarella S, Dahlberg SE, Jackman DM, Ramaiya NH, Hatabu H, Rabin MS, Jänne PA, Johnson BE. Radiographic assessment and therapeutic decisions at RECIST progression in EGFR-mutant NSCLC treated with EGFR tyrosine kinase inhibitors. Lung Cancer. 2013 Mar; 79(3):283-8.
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Shinagare AB, Okajima Y, Oxnard GR, Dipiro PJ, Johnson BE, Hatabu H, Nishino M. Unsuspected pulmonary embolism in lung cancer patients: comparison of clinical characteristics and outcome with suspected pulmonary embolism. Lung Cancer. 2012 Nov; 78(2):161-6.
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Nishino M, Cryer SK, Okajima Y, Sholl LM, Hatabu H, Rabin MS, Jackman DM, Johnson BE. Tumoral cavitation in patients with non-small-cell lung cancer treated with antiangiogenic therapy using bevacizumab. Cancer Imaging. 2012 Jun 29; 12:225-35.
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Nishino M, Jagannathan JP, Krajewski KM, O'Regan K, Hatabu H, Shapiro G, Ramaiya NH. Personalized tumor response assessment in the era of molecular medicine: cancer-specific and therapy-specific response criteria to complement pitfalls of RECIST. AJR Am J Roentgenol. 2012 Apr; 198(4):737-45.
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Chen Z, Cheng K, Walton Z, Wang Y, Ebi H, Shimamura T, Liu Y, Tupper T, Ouyang J, Li J, Gao P, Woo MS, Xu C, Yanagita M, Altabef A, Wang S, Lee C, Nakada Y, Peña CG, Sun Y, Franchetti Y, Yao C, Saur A, Cameron MD, Nishino M, Hayes DN, Wilkerson MD, Roberts PJ, Lee CB, Bardeesy N, Butaney M, Chirieac LR, Costa DB, Jackman D, Sharpless NE, Castrillon DH, Demetri GD, Jänne PA, Pandolfi PP, Cantley LC, Kung AL, Engelman JA, Wong KK. A murine lung cancer co-clinical trial identifies genetic modifiers of therapeutic response. Nature. 2012 Mar 18; 483(7391):613-7.
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Doyle TJ, Washko GR, Fernandez IE, Nishino M, Okajima Y, Yamashiro T, Divo MJ, Celli BR, Sciurba FC, Silverman EK, Hatabu H, Rosas IO, Hunninghake GM. Interstitial lung abnormalities and reduced exercise capacity. Am J Respir Crit Care Med. 2012 Apr 01; 185(7):756-62.
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Xu JF, Washko GR, Nakahira K, Hatabu H, Patel AS, Fernandez IE, Nishino M, Okajima Y, Yamashiro T, Ross JC, Estépar RS, Diaz AA, Li HP, Qu JM, Himes BE, Come CE, D'Aco K, Martinez FJ, Han MK, Lynch DA, Crapo JD, Morse D, Ryter SW, Silverman EK, Rosas IO, Choi AM, Hunninghake GM. Statins and pulmonary fibrosis: the potential role of NLRP3 inflammasome activation. Am J Respir Crit Care Med. 2012 Mar 01; 185(5):547-56.
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Washko GR, Hunninghake GM, Fernandez IE, Nishino M, Okajima Y, Yamashiro T, Ross JC, Estépar RS, Lynch DA, Brehm JM, Andriole KP, Diaz AA, Khorasani R, D'Aco K, Sciurba FC, Silverman EK, Hatabu H, Rosas IO. Lung volumes and emphysema in smokers with interstitial lung abnormalities. N Engl J Med. 2011 Mar 10; 364(10):897-906.
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Shinagare AB, Guo M, Hatabu H, Krajewski KM, Andriole K, Van den Abbeele AD, DiPiro PJ, Nishino M. Incidence of pulmonary embolism in oncologic outpatients at a tertiary cancer center. Cancer. 2011 Aug 15; 117(16):3860-6.
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Nishino M, Jackman DM, Hatabu H, Jänne PA, Johnson BE, Van den Abbeele AD. Imaging of lung cancer in the era of molecular medicine. Acad Radiol. 2011 Apr; 18(4):424-36.
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Nishino M, Guo M, Jackman DM, DiPiro PJ, Yap JT, Ho TK, Hatabu H, Jänne PA, Van den Abbeele AD, Johnson BE. CT tumor volume measurement in advanced non-small-cell lung cancer: Performance characteristics of an emerging clinical tool. Acad Radiol. 2011 Jan; 18(1):54-62.
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O'Regan KN, Nishino M, Armand P, Kelly PJ, Hwang DG, Di Salvo D. Sonographic features of pectoralis muscle necrosis secondary to gemcitabine-induced radiation recall: case report and review of current literature. J Ultrasound Med. 2010 Oct; 29(10):1499-502.
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Nishino M, Jackman DM, Hatabu H, Yeap BY, Cioffredi LA, Yap JT, Jänne PA, Johnson BE, Van den Abbeele AD. New Response Evaluation Criteria in Solid Tumors (RECIST) guidelines for advanced non-small cell lung cancer: comparison with original RECIST and impact on assessment of tumor response to targeted therapy. AJR Am J Roentgenol. 2010 Sep; 195(3):W221-8.
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Nishino M, Jagannathan JP, Ramaiya NH, Van den Abbeele AD. Revised RECIST guideline version 1.1: What oncologists want to know and what radiologists need to know. AJR Am J Roentgenol. 2010 Aug; 195(2):281-9.
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Nishino M, Patrick JL, Connors JM. Case 155: Lane-Hamilton syndrome. Radiology. 2010 Mar; 254(3):985-8.
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Nishino M, Washko GR, Hatabu H. Volumetric expiratory HRCT of the lung: clinical applications. Thorac Surg Clin. 2010 Feb; 20(1):121-7, viii-ix.
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Nishino M, Washko GR, Hatabu H. Volumetric expiratory HRCT of the lung: clinical applications. Radiol Clin North Am. 2010 Jan; 48(1):177-83.
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Nishino M, Lee KS, Itoh H, Hatabu H. The spectrum of pulmonary sarcoidosis: variations of high-resolution CT findings and clues for specific diagnosis. Eur J Radiol. 2010 Jan; 73(1):66-73.
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Kido A, Togashi K, Nishino M, Miyake K, Koyama T, Fujimoto R, Iwasaku K, Fujii S, Hayakawa K. Cine MR imaging of uterine peristalsis in patients with endometriosis. Eur Radiol. 2007 Jul; 17(7):1813-9.
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Kubo T, Nishino M, Kino A, Yoshimura N, Lin PJ, Takahashi M, Raptopoulos V, Hatabu H. 3-dimensional adaptive raw-data filter: evaluation in low dose chest multidetector-row computed tomography. J Comput Assist Tomogr. 2006 Nov-Dec; 30(6):933-8.
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Ward VL, Nishino M, Hatabu H, Estroff JA, Barnewolt CE, Feldman HA, Levine D. Fetal lung volume measurements: determination with MR imaging--effect of various factors. Radiology. 2006 Jul; 240(1):187-93.
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Nishino M, Roberts DH, Sitek A, Raptopoulos V, Boiselle PM, Hatabu H. Loss of anteroposterior intralobar attenuation gradient of the lung: Correlation with pulmonary function. Acad Radiol. 2006 May; 13(5):589-97.
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Kuroki M, Nishino M, Takahashi M, Mori Y, Raptopoulos VD, Boiselle PM, Tamura S, Hatabu H. Incidence of pulmonary embolism in younger versus older patients using CT. J Thorac Imaging. 2006 May; 21(2):167-71.
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Nishino M, Siewert B, Roberts DH, Gautam S, Boiselle PM, Raptopoulos V, Hatabu H. Excessive collapsibility of bronchi in bronchiectasis: evaluation on volumetric expiratory high-resolution CT. J Comput Assist Tomogr. 2006 May-Jun; 30(3):474-8.
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Nishino M, Kubo T, Kataoka ML, Raptopoulos V, Hatabu H. Coronal reformations of the chest on 64-row multi-detector row CT: evaluation of image quality in comparison with 16-, 8- and 4-row multi-detector row CT. Eur J Radiol. 2006 Aug; 59(2):231-7.
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Nishino M, Ashiku SK, Kocher ON, Thurer RL, Boiselle PM, Hatabu H. The thymus: a comprehensive review. Radiographics. 2006 Mar-Apr; 26(2):335-48.
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Nishino M, Kubo T, Kataoka ML, Gautam S, Raptopoulos V, Hatabu H. Evaluation of pulmonary embolisms using coronal reformations on 64-row multidetector-row computed tomography: Comparison with axial images. J Comput Assist Tomogr. 2006 Mar-Apr; 30(2):233-7.
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Nishino M, Kubo T, Kataoka ML, Gautam S, Raptopoulos V, Hatabu H. Evaluation of thoracic abnormalities on 64-row multi-detector row CT: comparison between axial images versus coronal reformations. Eur J Radiol. 2006 Jul; 59(1):33-41.
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Miyake K, Hayakawa K, Nishino M, Nakamura Y, Morimoto T, Urata Y, Ueda H, Tanikake M, Kanao S, Shiozaki T, Yamamoto A. Benign or malignant?: differentiating breast lesions with computed tomography attenuation values on dynamic computed tomography mammography. J Comput Assist Tomogr. 2005 Nov-Dec; 29(6):772-9.
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Nishino M, Hatabu H. Volumetric expiratory HRCT imaging with MSCT. J Thorac Imaging. 2005 Aug; 20(3):176-85.
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Miyake K, Hayakawa K, Nishino M, Morimoto T, Mukaihara S. Effects of oral 5-fluorouracil drugs on hepatic fat content in patients with colon cancer. Acad Radiol. 2005 Jun; 12(6):722-7.
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Nishino M, Kuroki M, Roberts DH, Mori Y, Boiselle PM, Hatabu H. Bronchomalacia in sarcoidosis: evaluation on volumetric expiratory high-resolution CT of the lung. Acad Radiol. 2005 May; 12(5):596-601.
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Boiselle PM, Hasegawa I, Nishino M, Raptopoulos V, Hatabu H. Comparison of artifacts on coronal reformation and axial CT pulmonary angiography images using single-detector and 4- and 8-detector multidetector-row helical CT scanners. Acad Radiol. 2005 May; 12(5):602-7.
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Baroni RH, Feller-Kopman D, Nishino M, Hatabu H, Loring SH, Ernst A, Boiselle PM. Tracheobronchomalacia: comparison between end-expiratory and dynamic expiratory CT for evaluation of central airway collapse. Radiology. 2005 May; 235(2):635-41.
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Nishino M, Iwata S, Hayakawa K, Kanao S, Morimoto T, Mukaihara S, Hatabu H. Functional evaluation of the postoperative gastrointestinal tract using kinematic MR imaging: Quantitative assessment of peristaltic activity. Eur J Radiol. 2005 Feb; 53(2):263-7.
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Yam CS, Levine D, Nishino M, Sitek A, Larson M. A simple method for displaying cine images on web-based teaching files. AJR Am J Roentgenol. 2005 Feb; 184(2):691-4.
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Nishino M, Togashi K, Nakai A, Hayakawa K, Kanao S, Iwasaku K, Fujii S. Uterine contractions evaluated on cine MR imaging in patients with uterine leiomyomas. Eur J Radiol. 2005 Jan; 53(1):142-6.
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Nishino M, Kuroki M, Boiselle PM, Raptopoulos V, Hatabu H. Sagittal reformations of volumetric inspiratory and expiratory high-resolution CT of the lung. Acad Radiol. 2004 Nov; 11(11):1282-90.
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Nishino M, Hatabu H. Volumetric expiratory high-resolution CT of the lung. Eur J Radiol. 2004 Nov; 52(2):180-4.
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Nishino M, Wolfe D, Yam CS, Larson M, Boiselle PM, Hatabu H. Comprehensive innovative solution for resident education using the Intranet Journal of Chest Radiology. Acad Radiol. 2004 Oct; 11(10):1149-52.
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Itoh H, Nishino M, Hatabu H. Architecture of the lung: morphology and function. J Thorac Imaging. 2004 Oct; 19(4):221-7.
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Nishino M, Busch JM, Wei J, Barbaras L, Yam CS, Hatabu H. Use of personal digital assistants in diagnostic radiology resident education. Acad Radiol. 2004 Oct; 11(10):1153-8.
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Busch JM, Barbaras L, Wei J, Nishino M, Yam CS, Hatabu H. A mobile solution: PDA-based platform for radiology information management. AJR Am J Roentgenol. 2004 Jul; 183(1):237-42.
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Nishino M, Hayakawa K, Iwasaku K, Togashi K, Ueda H, Sago T, Noguchi M. MR imaging of ovarian hemorrhage. Eur J Radiol. 2004 Jul; 51(1):34-40.
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Nishino M, Kuroki M, Boiselle PM, Copeland JF, Raptopoulos V, Hatabu H. Coronal reformations of volumetric expiratory high-resolution CT of the lung. AJR Am J Roentgenol. 2004 Apr; 182(4):979-82.
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Nakayama T, Nishino M, Takasu K, Hayakawa K, Toguchida J, Tanaka C. Endovascular papillary angioendothelioma (Dabska tumor) of bone. Orthopedics. 2004 Mar; 27(3):327-8.
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Nishino M, Boiselle PM, Copeland JF, Raptopoulos V, Hatabu H. Value of volumetric data acquisition in expiratory high-resolution computed tomography of the lung. J Comput Assist Tomogr. 2004 Mar-Apr; 28(2):209-14.
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Nishino M, Hayakawa K, Yamamoto A, Nakamura Y, Morimoto T, Mukaihara S, Urata Y. Multiple enhancing lesions detected on dynamic helical computed tomography-mammography. J Comput Assist Tomogr. 2003 Sep-Oct; 27(5):771-8.
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Nishino M, Hayakawa K, Iwasaku K, Takasu K. Magnetic resonance imaging findings in gynecologic emergencies. J Comput Assist Tomogr. 2003 Jul-Aug; 27(4):564-70.
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Nishino M, Hayakawa K, Iwasaku K, Hirasugi Y, Takasu K. Journal of Women’s Imaging. MR Appearance of the Mature Cystic Teratoma of the Ovary with Malignant Transformation to Spindle Cell Carcinoma. 2003; (5):83-86.
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Nishino M, Hayakawa K, Nakamura Y, Morimoto T, Mukaihara S. Effects of tamoxifen on hepatic fat content and the development of hepatic steatosis in patients with breast cancer: high frequency of involvement and rapid reversal after completion of tamoxifen therapy. AJR Am J Roentgenol. 2003 Jan; 180(1):129-34.
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Nishino M, Hayakawa K, Miki Y. . Head and neck tuberculosis. Clinical Imagiology. 2003; (19):508-515. Review (in Japanese)..
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Nishino M, Hayakawa K, Minami M, Yamamoto A, Ueda H, Takasu K. Primary retroperitoneal neoplasms: CT and MR imaging findings with anatomic and pathologic diagnostic clues. Radiographics. 2003 Jan-Feb; 23(1):45-57.
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Nishino M, Hayakawa K, Kawamata K, Iwasaku K, Takasu K. MRI of early unruptured ectopic pregnancy: detection of gestational sac. J Comput Assist Tomogr. 2002 Jan-Feb; 26(1):134-7.
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