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Rachel A. Freedman, MD, MPH


Medical Oncology

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Physician

  • Medical Director, DFCI Cancer Care Collaborative
  • Senior Physician
  • Associate Professor of Medicine, Harvard Medical School

Centers/Programs

Diseases Treated

Contact Information

  • Appointments617-632-2175 (new)
    617-632-3800 (follow-up)
  • Office Phone Number617-632-3800
  • Fax617-632-1930

Bio

Physician Profile Video

Board Certification:

  • Internal Medicine, 2006
  • Medical Oncology, 2008

Fellowship:

  • Dana-Farber/Partners CancerCare, Medical Oncology

Residency:

  • Beth Israel Deaconess Medical Center, Internal Medicine

Medical School:

  • Georgetown University School of Medicine

Research

Factors associated with late risks of breast cancer-specific mortality in the SEER registry. Breast Cancer Res Treat. 2021 Apr 24.
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Weathering the Storm: Managing Older Adults With Breast Cancer Amid COVID-19 and Beyond. J Natl Cancer Inst. 2021 04 06; 113(4):355-359.
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Individualizing Surveillance Mammography for Older Patients After Treatment for Early-Stage Breast Cancer: Multidisciplinary Expert Panel and International Society of Geriatric Oncology Consensus Statement. JAMA Oncol. 2021 Apr 01; 7(4):609-615.
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Tumor subtypes and survival in male breast cancer. Breast Cancer Res Treat. 2021 Mar 26.
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Acceptability of a patient decision aid for women aged 70 and older with stage I, estrogen receptor-positive, HER2-negative breast cancer. J Geriatr Oncol. 2021 Mar 04.
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Twenty-year risks of breast cancer-specific mortality for stage III breast cancer in the surveillance, epidemiology, and end results registry. Breast Cancer Res Treat. 2021 Feb 16.
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Phase I study of JAK1/2 inhibitor ruxolitinib with weekly paclitaxel for the treatment of HER2-negative metastatic breast cancer. Cancer Chemother Pharmacol. 2021 May; 87(5):673-679.
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Development and Validation of a Risk Tool for Predicting Severe Toxicity in Older Adults Receiving Chemotherapy for Early-Stage Breast Cancer. J Clin Oncol. 2021 Feb 20; 39(6):608-618.
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Phase II trial of carboplatin and bevacizumab in patients with breast cancer brain metastases. Breast Cancer Res. 2020 11 30; 22(1):131.
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Selection of Optimal Adjuvant Chemotherapy and Targeted Therapy for Early Breast Cancer: ASCO Guideline Update. J Clin Oncol. 2021 Feb 20; 39(6):685-693.
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A dynamic portrait of adverse events for breast cancer patients: results from a phase II clinical trial of eribulin in advanced HER2-negative breast cancer. Breast Cancer Res Treat. 2021 Jan; 185(1):135-144.
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Older adult participation in cancer clinical trials: A systematic review of barriers and interventions. CA Cancer J Clin. 2021 Jan; 71(1):78-92.
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Oncotype DX testing in node-positive breast cancer strongly impacts chemotherapy use at a comprehensive cancer center. Breast Cancer Res Treat. 2021 Jan; 185(1):215-227.
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Menopausal Hormone Therapy and Long-term Breast Cancer Risk: Further Data From the Women's Health Initiative Trials. JAMA. 2020 07 28; 324(4):347-349.
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Adjuvant Chemotherapy for Older Patients With Breast Cancer: When Is the Pain Worth the Gain? J Natl Cancer Inst. 2020 06 01; 112(6):551-552.
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Translating research into practice: Protocol for a community-engaged, stepped wedge randomized trial to reduce disparities in breast cancer treatment through a regional patient navigation collaborative. Contemp Clin Trials. 2020 06; 93:106007.
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Engaging Patients in Precision Oncology: Development and Usability of a Web-Based Patient-Facing Genomic Sequencing Report. JCO Precis Oncol. 2020; 4.
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HER2-Mediated Internalization of Cytotoxic Agents in ERBB2 Amplified or Mutant Lung Cancers. Cancer Discov. 2020 May; 10(5):674-687.
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Follow-up Care for Breast Cancer Survivors. J Natl Cancer Inst. 2020 01 01; 112(1):111-113.
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Identifying ERBB2 Activating Mutations in HER2-Negative Breast Cancer: Clinical Impact of Institute-Wide Genomic Testing and Enrollment in Matched Therapy Trials. JCO Precis Oncol. 2019; 3.
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Acupuncture for Chemotherapy-Induced Peripheral Neuropathy in Breast Cancer Survivors: A Randomized Controlled Pilot Trial. Oncologist. 2020 04; 25(4):310-318.
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Acupuncture for Chemotherapy-Induced Peripheral Neuropathy in Breast Cancer Survivors: A Randomized Controlled Pilot Trial. Oncologist. 2019 Oct 14.
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Patterns of Axillary Management in Stages 2 and 3 Hormone Receptor-Positive Breast Cancer by Initial Treatment Approach. Ann Surg Oncol. 2019 Dec; 26(13):4326-4336.
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Standardized activities for lay patient navigators in breast cancer care: Recommendations from a citywide implementation study. Cancer. 2019 12 15; 125(24):4532-4540.
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Pre- and Postoperative Neratinib for HER2-Positive Breast Cancer Brain Metastases: Translational Breast Cancer Research Consortium 022. Clin Breast Cancer. 2020 04; 20(2):145-151.e2.
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21-Gene Recurrence Score Adds Significant Value for Grade 3 Breast Cancers: Results From a National Cohort. JCO Precis Oncol. 2019; 3.
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Interferon Signaling Is Diminished with Age and Is Associated with Immune Checkpoint Blockade Efficacy in Triple-Negative Breast Cancer. Cancer Discov. 2019 09; 9(9):1208-1227.
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Breast cancer and aging: Standing on the shoulders of a giant. J Geriatr Oncol. 2020 03; 11(2):212-216.
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Arti Hurria, M.D.: A tribute to her shining legacy in the Alliance for Clinical Trials in Oncology. J Geriatr Oncol. 2020 03; 11(2):179-183.
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Developing a patient decision aid for women aged 70 and older with early stage, estrogen receptor positive, HER2 negative, breast cancer. J Geriatr Oncol. 2019 11; 10(6):980-986.
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Impact of a Pre-Operative Exercise Intervention on Breast Cancer Proliferation and Gene Expression: Results from the Pre-Operative Health and Body (PreHAB) Study. Clin Cancer Res. 2019 Sep 01; 25(17):5398-5406.
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Who Are the Patients in Our Clinical Trials for Cancer? J Clin Oncol. 2019 06 20; 37(18):1519-1523.
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Treatment Patterns Among De Novo Metastatic Cancer Patients Who Died Within 1 Month of Diagnosis. JNCI Cancer Spectr. 2019 Jun; 3(2):pkz021.
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Older-Patient-Specific Cancer Trials: A Pooled Analysis of 2,277 Patients (A151715). Oncologist. 2019 06; 24(6):e284-e291.
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TBCRC 022: A Phase II Trial of Neratinib and Capecitabine for Patients With Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer and Brain Metastases. J Clin Oncol. 2019 05 01; 37(13):1081-1089.
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Impact of Subtype on Survival of Young Patients With Stage IV Breast Cancer. Clin Breast Cancer. 2019 06; 19(3):200-207.e1.
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Clinical Impact of Second Opinion Radiology Consultation for Patients With Breast Cancer. J Am Coll Radiol. 2019 Jun; 16(6):814-823.
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Examining Associations of Racial Residential Segregation With Patient Knowledge of Breast Cancer and Treatment Receipt. Clin Breast Cancer. 2019 06; 19(3):178-187.e3.
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Age and the Risk of Paclitaxel-Induced Neuropathy in Women with Early-Stage Breast Cancer (Alliance A151411): Results from 1,881 Patients from Cancer and Leukemia Group B (CALGB) 40101. Oncologist. 2019 05; 24(5):617-623.
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Haemophagocytic lymphohistiocytosis complicating pembrolizumab treatment for metastatic breast cancer in a patient with the PRF1A91V gene polymorphism. J Med Genet. 2019 01; 56(1):39-42.
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Treatment Patterns Among Women Diagnosed With Stage I-III Triple-negative Breast Cancer. Am J Clin Oncol. 2018 10; 41(10):997-1007.
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Functional Decline and Resilience in Older Women Receiving Adjuvant Chemotherapy for Breast Cancer. J Am Geriatr Soc. 2019 05; 67(5):920-927.
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Impact of Genomic Assay Testing and Clinical Factors on Chemotherapy Use After Implementation of Standardized Testing Criteria. Oncologist. 2019 05; 24(5):595-602.
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Adherence to Guidelines for Breast Surveillance in Breast Cancer Survivors. J Natl Compr Canc Netw. 2018 05; 16(5):526-534.
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Promoting Accrual of Older Patients with Cancer to Clinical Trials: An Alliance for Clinical Trials in Oncology Member Survey (A171602). Oncologist. 2018 09; 23(9):1016-1023.
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Breast cancer-specific survival by age: Worse outcomes for the oldest patients. Cancer. 2018 05 15; 124(10):2184-2191.
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Morbidity of local therapy for locally advanced metastatic breast cancer: an analysis of the Surveillance, Epidemiology, and End Results (SEER)-Medicare Registry. Breast Cancer Res Treat. 2018 Jun; 169(2):287-293.
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Variation in guideline-concordant care for elderly patients with metastatic breast cancer in the United States. Breast Cancer Res Treat. 2018 Apr; 168(3):727-737.
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Understanding Breast Cancer Knowledge and Barriers to Treatment Adherence: A Qualitative Study Among Breast Cancer Survivors. Biores Open Access. 2017; 6(1):159-168.
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Efficacy and safety in older patient subsets in studies of endocrine monotherapy versus combination therapy in patients with HR+/HER2- advanced breast cancer: a review. Breast Cancer Res Treat. 2018 02; 167(3):607-614.
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Factors That Contributed to Black-White Disparities in Survival Among Nonelderly Women With Breast Cancer Between 2004 and 2013. J Clin Oncol. 2018 01 01; 36(1):14-24.
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Patterns of axillary evaluation in older patients with breast cancer and associations with adjuvant therapy receipt. Breast Cancer Res Treat. 2018 01; 167(2):555-566.
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Breast Cancer Survivorship Care Variations Between Adjuvant Chemotherapy Regimens. Clin Breast Cancer. 2018 08; 18(4):e513-e520.
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Implementation of Surgeon-Initiated Gene Expression Profile Testing (Onco type DX) Among Patients With Early-Stage Breast Cancer to Reduce Delays in Chemotherapy Initiation. J Oncol Pract. 2017 09; 13(9):e815-e820.
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Trends in adjuvant therapies after breast-conserving surgery for hormone receptor-positive ductal carcinoma in situ: findings from the National Cancer Database, 2004-2013. Breast Cancer Res Treat. 2017 Nov; 166(2):583-592.
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Feasibility Assessment of Patient Reporting of Symptomatic Adverse Events in Multicenter Cancer Clinical Trials. JAMA Oncol. 2017 Aug 01; 3(8):1043-1050.
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Use of Surveillance Mammography Among Older Breast Cancer Survivors by Life Expectancy. J Clin Oncol. 2017 Sep 20; 35(27):3123-3130.
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Neratinib Efficacy and Circulating Tumor DNA Detection of HER2 Mutations in HER2 Nonamplified Metastatic Breast Cancer. Clin Cancer Res. 2017 Oct 01; 23(19):5687-5695.
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State Variation in the Receipt of a Contralateral Prophylactic Mastectomy Among Women Who Received a Diagnosis of Invasive Unilateral Early-Stage Breast Cancer in the United States, 2004-2012. JAMA Surg. 2017 07 01; 152(7):648-657.
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Emerging Data and Current Challenges for Young, Old, Obese, or Male Patients with Breast Cancer. Clin Cancer Res. 2017 Jun 01; 23(11):2647-2654.
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Impact of treatment regimen on acute care use during and after adjuvant chemotherapy for early-stage breast cancer. Breast Cancer Res Treat. 2017 Aug; 164(3):515-525.
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Using ePrognosis to estimate 2-year all-cause mortality in older women with breast cancer: Cancer and Leukemia Group B (CALGB) 49907 and 369901 (Alliance A151503). Breast Cancer Res Treat. 2017 Jun; 163(2):391-398.
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Patterns of Utilization of Imaging Studies and Serum Tumor Markers Among Patients With De Novo Metastatic Breast Cancer. J Natl Compr Canc Netw. 2017 03; 15(3):316-324.
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Growing Use of Contralateral Prophylactic Mastectomy Despite no Improvement in Long-term Survival for Invasive Breast Cancer. Ann Surg. 2017 03; 265(3):581-589.
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Surveillance Mammography in Older Patients With Breast Cancer-Can We Ever Stop?: A Review. JAMA Oncol. 2017 Mar 01; 3(3):402-409.
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Prior Authorization for Medications in a Breast Oncology Practice: Navigation of a Complex Process. J Oncol Pract. 2017 04; 13(4):e273-e282.
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Factors Associated with Early Mortality Among Patients with De Novo Metastatic Breast Cancer: A Population-Based Study. Oncologist. 2017 04; 22(4):386-393.
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Persistence of dysphagia and odynophagia after mediastinal radiation and chemotherapy in patients with lung cancer or lymphoma. Dis Esophagus. 2017 02 01; 30(2):1-8.
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Accrual of Older Patients With Breast Cancer to Alliance Systemic Therapy Trials Over Time: Protocol A151527. J Clin Oncol. 2017 Feb; 35(4):421-431.
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Effect of the LIVESTRONG at the YMCA exercise program on physical activity, fitness, quality of life, and fatigue in cancer survivors. Cancer. 2017 Apr 01; 123(7):1249-1258.
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Risk of acute myeloid leukemia and myelodysplastic syndrome among older women receiving anthracycline-based adjuvant chemotherapy for breast cancer on Modern Cooperative Group Trials (Alliance A151511). Breast Cancer Res Treat. 2017 01; 161(2):363-373.
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Treatment of early-stage human epidermal growth factor 2-positive cancers among medicare enrollees: age and race strongly associated with non-use of trastuzumab. Breast Cancer Res Treat. 2016 08; 159(1):151-62.
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Reply to K. Lin et al. J Clin Oncol. 2016 10 01; 34(28):3485-6.
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Learning from social media: utilizing advanced data extraction techniques to understand barriers to breast cancer treatment. Breast Cancer Res Treat. 2016 07; 158(2):395-405.
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Time trends in incidence rates and survival of newly diagnosed stage IV breast cancer by tumor histology: a population-based analysis. Breast Cancer Res Treat. 2016 06; 157(3):587-96.
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Association of Breast Cancer Knowledge With Receipt of Guideline-Recommended Breast Cancer Treatment. J Oncol Pract. 2016 06; 12(6):e613-25.
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Growing Use of Contralateral Prophylactic Mastectomy Despite no Improvement in Long-term Survival for Invasive Breast Cancer. Ann Surg. 2016 Mar 08.
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Patient Prognostic Score and Associations With Survival Improvement Offered by Radiotherapy After Breast-Conserving Surgery for Ductal Carcinoma In Situ: A Population-Based Longitudinal Cohort Study. J Clin Oncol. 2016 Apr 10; 34(11):1190-6.
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Translational Breast Cancer Research Consortium (TBCRC) 022: A Phase II Trial of Neratinib for Patients With Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer and Brain Metastases. J Clin Oncol. 2016 Mar 20; 34(9):945-52.
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Location Isn't Everything: Proximity, Hospital Characteristics, Choice of Hospital, and Disparities for Breast Cancer Surgery Patients. Health Serv Res. 2016 Aug; 51(4):1561-83.
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Factors associated with radiation therapy incompletion for patients with early-stage breast cancer. Breast Cancer Res Treat. 2016 Jan; 155(1):187-99.
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Temporal Trends in and Factors Associated With Contralateral Prophylactic Mastectomy Among US Men With Breast Cancer. JAMA Surg. 2015 Dec; 150(12):1192-4.
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Treatment of Breast Cancer in the Elderly. Curr Oncol Rep. 2015 Nov; 17(11):51.
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The effect of Paget disease on axillary lymph node metastases and survival in invasive ductal carcinoma. Cancer. 2015 Dec 15; 121(24):4333-40.
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Higher Stage of Disease Is Associated With Bilateral Mastectomy Among Patients With Breast Cancer: A Population-Based Survey. Clin Breast Cancer. 2016 Apr; 16(2):105-12.
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Modern Trends in the Surgical Management of Paget's Disease. Ann Surg Oncol. 2015 Oct; 22(10):3308-16.
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How Do Payers Respond to Regulatory Actions? The Case of Bevacizumab. J Oncol Pract. 2015 Jul; 11(4):313-8.
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Racial differences in outcomes for patients with metastatic breast cancer by disease subtype. Breast Cancer Res Treat. 2015 Jun; 151(3):697-707.
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Black/White Disparities in Receipt of Treatment and Survival Among Men With Early-Stage Breast Cancer. J Clin Oncol. 2015 Jul 20; 33(21):2337-44.
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Racial/Ethnic Differences in Patients' Selection of Surgeons and Hospitals for Breast Cancer Surgery. JAMA Oncol. 2015 May; 1(2):222-30.
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Racial/ethnic disparities in knowledge about one's breast cancer characteristics. Cancer. 2015 Mar 01; 121(5):724-32.
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Patterns of chemotherapy, toxicity, and short-term outcomes for older women receiving adjuvant trastuzumab-based therapy. Breast Cancer Res Treat. 2014 Jun; 145(2):491-501.
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Duration and toxicity of adjuvant trastuzumab in older patients with early-stage breast cancer: a population-based study. J Clin Oncol. 2014 Mar 20; 32(9):927-34.
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A novel community-based delivery model to combat cancer disparities. Healthc (Amst). 2013 Dec; 1(3-4):123-9.
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Using FastTrack to Implement an Academic Medical Center and Community Health Center Collaborative for Cancer Care Delivery. Healthc (Amst). 2013 Dec; 1(3-4):130-135.
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A phase I study of lapatinib with whole brain radiotherapy in patients with Human Epidermal Growth Factor Receptor 2 (HER2)-positive breast cancer brain metastases. Breast Cancer Res Treat. 2013 Nov; 142(2):405-14.
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Managing metastatic human epidermal growth factor receptor 2 (HER2)-positive breast cancer in the older patient. J Geriatr Oncol. 2014 Jan; 5(1):2-7.
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Management of breast cancer in very young women. Breast. 2013 Aug; 22 Suppl 2:S176-9.
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Cognitive function in older women with breast cancer treated with standard chemotherapy and capecitabine on Cancer and Leukemia Group B 49907. Breast Cancer Res Treat. 2013 Jun; 139(2):607-16.
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Racial/Ethnic differences in receipt of timely adjuvant therapy for older women with breast cancer: are delays influenced by the hospitals where patients obtain surgical care? Health Serv Res. 2013 Oct; 48(5):1669-83.
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Trends in co-prescribing of antidepressants and tamoxifen among women with breast cancer, 2004-2010. Breast Cancer Res Treat. 2013 Jan; 137(1):285-96.
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Use of adjuvant trastuzumab in women with human epidermal growth factor receptor 2 (HER2)-positive breast cancer by race/ethnicity and education within the National Comprehensive Cancer Network. Cancer. 2013 Feb 15; 119(4):839-46.
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Receipt of locoregional therapy among young women with breast cancer. Breast Cancer Res Treat. 2012 Oct; 135(3):893-906.
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Treatment of Breast Cancer Brain Metastases. Curr Breast Cancer Rep. 2012 Mar 01; 4(1):1-9.
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Adjuvant therapies for very young women with early stage breast cancer. Breast. 2011 Oct; 20 Suppl 3:S146-9.
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A phase II study of sagopilone (ZK 219477; ZK-EPO) in patients with breast cancer and brain metastases. Clin Breast Cancer. 2011 Dec; 11(6):376-83.
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Family cancer history: healthy skepticism required. J Natl Cancer Inst. 2011 May 18; 103(10):776-7.
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The association of race/ethnicity, insurance status, and socioeconomic factors with breast cancer care. Cancer. 2011 Jan 01; 117(1):180-9.
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Adjuvant therapy for postmenopausal women with endocrine-sensitive breast cancer. Breast. 2010 Apr; 19(2):69-75.
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Trends in racial and age disparities in definitive local therapy of early-stage breast cancer. J Clin Oncol. 2009 Feb 10; 27(5):713-9.
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Reducing disparities in breast cancer care: a daunting but essential responsibility. J Natl Cancer Inst. 2008 Dec 03; 100(23):1661-3.
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Timing of postpartum enoxaparin administration and severe postpartum hemorrhage. Blood Coagul Fibrinolysis. 2008 Jan; 19(1):55-9.
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Glioblastoma in a patient with early-stage tonsil cancer. J Clin Oncol. 2007 Jul 01; 25(19):2848-50.
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