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Rebecca S. Gelman, PhD


Researcher

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Rebecca S. Gelman, PhD

Researcher

  • Associate Professor of Medicine, Harvard Medical School
  • Associate Professor of Biostatistics, Harvard T.H. Chan School of Public Health

Contact Information

  • Office Phone Number(617) 632-3629
  • Fax(617) 632-2444

Bio

Dr. Gelman received her PhD in statistics from the State University of New York, Buffalo, in 1978. In the same year, she joined the Department of Biostatistics at Harvard School of Public Health and DFCI, and in 1990, the Department of Radiation Oncology at Harvard Medical School. She is associate director of the Biostatistics Core of the Dana-Farber/Harvard Cancer Center, principal investigator of the Biostatistics Core of the Harvard Center for AIDS Research, and chief statistician for the National Institute of Allergy and Infectious Diseases (NIAID) Division of AIDS Immunology Laboratory Quality Assessment Program. She is the only statistician member of the Flow Advisory Committee to the NIAID.

Research

Biostatistics in Clinical Cancer Studies and AIDS Research

Our research involves two main areas: collaboration on cancer and HIV studies and the statistical problems arising from them. Our work is focused primarily on studies of breast cancer (both laboratory and clinical), radiation oncology, immunology, and evaluation of new immunology assays, particularly those involving flow cytometry. Recent research activities in cancer include (1) modeling the effects of screening and therapy on breast cancer mortality in the United States (with the NIH CISNET group), (2) designing xenograft growth experiments to assess the cancer-promotion abilities of various stromal and fibroblast cells, (3) assessing longitudinal circulating tumor markers in breast cancer, (4) designing breast cancer prevention pilot studies, and (5) analyzing long-term follow-up on several randomized breast cancer therapy trials. Recent research activities in HIV disease include (1) modeling changes in the distributions of percents and counts of various lymphocyte subsets in healthy children from birth to age 18 (for use as controls in pediatric HIV and cancer studies), (2) quantitating the co-localization of CD8 cells and JC virus (JCV)-infected glial cells in brain biopsies from patients with progressive multifocal leukoencephalopathy (PML) disease, (3) analyzing the effect of various immune maneuvers on the effectiveness of vaccines against simian-human immunodeficiency viruses (SHIV), and (4) designing and analyzing studies that compare the within-laboratory and between-laboratory variability in CD4 counts using either current methods or several cheaper and simpler methods being developed for use in the third world. Our statistical interests include methods (1) to analyze nonindependent competing risks, (2) to assess the surrogate value of longitudinal markers in cancer and HIV disease (particularly methods that incorporate external information on within-laboratory and between-laboratory variation in assessing these markers), and (3) to assess the heterogeneity of distributions of various types of cells in pathology specimens or high-definition imaging techniques.

Impact of Genetic Counseling on Patient-Reported Electronic Cancer Family History Collection. J Natl Compr Canc Netw. 2022 08; 20(8):898-905.e2.
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Phase II trial of veliparib and temozolomide in metastatic breast cancer patients with and without BRCA1/2 mutations. Breast Cancer Res Treat. 2021 Oct; 189(3):641-651.
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Phase II trial of carboplatin and bevacizumab in patients with breast cancer brain metastases. Breast Cancer Res. 2020 11 30; 22(1):131.
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The Incidence of Adjacent Synchronous Invasive Carcinoma and/or Ductal Carcinoma In Situ in Patients with Intraductal Papilloma without Atypia on Core Biopsy: Results from a Prospective Multi-Institutional Registry (TBCRC 034). Ann Surg Oncol. 2021 May; 28(5):2573-2578.
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Pre- and Postoperative Neratinib for HER2-Positive Breast Cancer Brain Metastases: Translational Breast Cancer Research Consortium 022. Clin Breast Cancer. 2020 04; 20(2):145-151.e2.
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TBCRC 022: A Phase II Trial of Neratinib and Capecitabine for Patients With Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer and Brain Metastases. J Clin Oncol. 2019 05 01; 37(13):1081-1089.
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Induction of Tier 1 HIV Neutralizing Antibodies by Envelope Trimers Incorporated into a Replication Competent Vesicular Stomatitis Virus Vector. Viruses. 2019 02 15; 11(2).
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BRCA1-IRIS promotes human tumor progression through PTEN blockade and HIF-1a activation. Proc Natl Acad Sci U S A. 2018 10 09; 115(41):E9600-E9609.
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Differences in TP53 Mutation Carrier Phenotypes Emerge From Panel-Based Testing. J Natl Cancer Inst. 2018 08 01; 110(8):863-870.
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Phase II study of ruxolitinib, a selective JAK1/2 inhibitor, in patients with metastatic triple-negative breast cancer. NPJ Breast Cancer. 2018; 4:10.
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Brief Report: High Sensitivity and Specificity of the Cepheid Xpert HIV-1 Qualitative Point-of-Care Test Among Newborns in Botswana. J Acquir Immune Defic Syndr. 2017 08 15; 75(5):e128-e131.
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HIV Testing Among Black and Hispanic Immigrants in the United States. AIDS Patient Care STDS. 2016 07; 30(7):307-14.
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BRCA1/FANCD2/BRG1-Driven DNA Repair Stabilizes the Differentiation State of Human Mammary Epithelial Cells. Mol Cell. 2016 07 21; 63(2):277-292.
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Translational Breast Cancer Research Consortium (TBCRC) 022: A Phase II Trial of Neratinib for Patients With Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer and Brain Metastases. J Clin Oncol. 2016 Mar 20; 34(9):945-52.
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Incidence of Adjacent Synchronous Invasive Carcinoma and/or Ductal Carcinoma In-situ in Patients with Lobular Neoplasia on Core Biopsy: Results from a Prospective Multi-Institutional Registry (TBCRC 020). Ann Surg Oncol. 2016 Mar; 23(3):722-8.
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Broad-spectrum antibodies against self-antigens and cytokines in RAG deficiency. J Clin Invest. 2015 Nov 02; 125(11):4135-48.
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Inhibitory Effect of Individual or Combinations of Broadly Neutralizing Antibodies and Antiviral Reagents against Cell-Free and Cell-to-Cell HIV-1 Transmission. J Virol. 2015 Aug; 89(15):7813-28.
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Control lymphocyte subsets: can one country's values serve for another's? J Allergy Clin Immunol. 2014 Sep; 134(3):759-761.e8.
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Eight-year update of a prospective study of wide excision alone for small low- or intermediate-grade ductal carcinoma in situ (DCIS). Breast Cancer Res Treat. 2014 Jan; 143(2):343-50.
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A phase I study of lapatinib with whole brain radiotherapy in patients with Human Epidermal Growth Factor Receptor 2 (HER2)-positive breast cancer brain metastases. Breast Cancer Res Treat. 2013 Nov; 142(2):405-14.
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Personalized medicine in breast cancer: tamoxifen, endoxifen, and CYP2D6 in clinical practice. Breast Cancer Res Treat. 2013 Oct; 141(3):421-7.
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Treatment of high-grade anal dysplasia in high-risk patients: outcome at an urban community health centre. Int J STD AIDS. 2013 Feb; 24(2):134-8.
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A phase II study of bevacizumab in combination with vinorelbine and trastuzumab in HER2-positive metastatic breast cancer. Breast Cancer Res Treat. 2013 Jun; 139(2):403-10.
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Prevalence of germline TP53 mutations in HER2+ breast cancer patients. Breast Cancer Res Treat. 2013 May; 139(1):193-8.
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Combination antiangiogenic therapy in advanced breast cancer: a phase 1 trial of vandetanib, a VEGFR inhibitor, and metronomic chemotherapy, with correlative platelet proteomics. Breast Cancer Res Treat. 2012 Nov; 136(1):169-78.
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Respiratory virus detection in immunocompromised patients with FilmArray respiratory panel compared to conventional methods. J Clin Microbiol. 2012 Oct; 50(10):3216-21.
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Association of activating KIR copy number variation of NK cells with containment of SIV replication in rhesus monkeys. PLoS Pathog. 2011 Dec; 7(12):e1002436.
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A phase II study of sagopilone (ZK 219477; ZK-EPO) in patients with breast cancer and brain metastases. Clin Breast Cancer. 2011 Dec; 11(6):376-83.
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TBCRC 003: Phase II trial of trastuzumab (T) and lapatinib (L) in patients (pts) with HER2+ metastatic breast cancer (MBC). J Clin Oncol. 2011 May 20; 29(15_suppl):527.
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Immune and Genetic Correlates of Vaccine Protection Against Mucosal Infection by SIV in Monkeys. Sci Transl Med. 2011 May 04; 3(81):81ra36.
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Characteristics of lymphocyte subsets in HIV-infected, long-term nonprogressor, and healthy Asian children through 12 years of age. J Allergy Clin Immunol. 2010 Dec; 126(6):1294-301.e10.
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Optimization of storage and shipment of cryopreserved peripheral blood mononuclear cells from HIV-infected and uninfected individuals for ELISPOT assays. J Immunol Methods. 2010 Dec 15; 363(1):42-50.
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Does neoadjuvant bevacizumab increase surgical complications in breast surgery? Ann Surg Oncol. 2011 Mar; 18(3):733-7.
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Contributions of Mamu-A*01 status and TRIM5 allele expression, but not CCL3L copy number variation, to the control of SIVmac251 replication in Indian-origin rhesus monkeys. PLoS Genet. 2010 Jun 24; 6(6):e1000997.
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PIK3CA mutations in in situ and invasive breast carcinomas. Cancer Res. 2010 Jul 15; 70(14):5674-8.
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Patient-reported acute gastrointestinal symptoms during concurrent chemoradiation treatment for rectal cancer. Cancer. 2010 Apr 15; 116(8):1879-86.
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Estrogen receptor positive breast cancers in BRCA1 mutation carriers: clinical risk factors and pathologic features. Breast Cancer Res. 2010; 12(1):R12.
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Heterogeneity for stem cell-related markers according to tumor subtype and histologic stage in breast cancer. Clin Cancer Res. 2010 Feb 01; 16(3):876-87.
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Efficacy of neoadjuvant Cisplatin in triple-negative breast cancer. J Clin Oncol. 2010 Mar 01; 28(7):1145-53.
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Tolerability and efficacy of 500 mg fulvestrant in postmenopausal women with estrogen receptor (ER)+ advanced breast cancer. J Clin Oncol. 2009 May 20; 27(15_suppl):1050.
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Determination of factors predicting for estrogen receptor positive (ER+) breast cancers in BRCA1 mutation carriers. J Clin Oncol. 2009 May 20; 27(15_suppl):11045.
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Neoadjuvant cisplatin and bevacizumab in triple negative breast cancer (TNBC): Safety and efficacy. J Clin Oncol. 2009 May 20; 27(15_suppl):551.
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Tolerability of and adherence to combination oral therapy with gefitinib and capecitabine in metastatic breast cancer. Breast Cancer Res Treat. 2009 Oct; 117(3):615-23.
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Role of COX-2 in epithelial-stromal cell interactions and progression of ductal carcinoma in situ of the breast. Proc Natl Acad Sci U S A. 2009 Mar 03; 106(9):3372-7.
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VEGF as a marker for outcome among advanced breast cancer patients receiving anti-VEGF therapy with bevacizumab and vinorelbine chemotherapy. Clin Cancer Res. 2008 Dec 01; 14(23):7871-7.
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Cell type-specific DNA methylation patterns in the human breast. Proc Natl Acad Sci U S A. 2008 Sep 16; 105(37):14076-81.
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Potent simian immunodeficiency virus-specific cellular immune responses in the breast milk of simian immunodeficiency virus-infected, lactating rhesus monkeys. J Immunol. 2008 Sep 01; 181(5):3643-50.
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Epithelial and stromal cathepsin K and CXCL14 expression in breast tumor progression. Clin Cancer Res. 2008 Sep 01; 14(17):5357-67.
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The impact of sharing results of a randomized breast cancer clinical trial with study participants. Breast Cancer Res Treat. 2009 May; 115(1):123-9.
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Regulation of in situ to invasive breast carcinoma transition. Cancer Cell. 2008 May; 13(5):394-406.
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Phase II trial of lapatinib for brain metastases in patients with human epidermal growth factor receptor 2-positive breast cancer. J Clin Oncol. 2008 Apr 20; 26(12):1993-9.
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A North American multilaboratory study of CD4 counts using flow cytometric panLeukogating (PLG): a NIAID-DAIDS Immunology Quality Assessment Program Study. Cytometry B Clin Cytom. 2008; 74 Suppl 1:S52-64.
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Incidence of major corrective surgery after post-mastectomy breast reconstruction and radiation therapy. Breast J. 2008 Jan-Feb; 14(1):49-54.
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Network modeling links breast cancer susceptibility and centrosome dysfunction. Nat Genet. 2007 Nov; 39(11):1338-49.
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Trastuzumab plus vinorelbine or taxane chemotherapy for HER2-overexpressing metastatic breast cancer: the trastuzumab and vinorelbine or taxane study. Cancer. 2007 Sep 01; 110(5):965-72.
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The virologic, immunologic, and clinical effects of interleukin 2 with potent antiretroviral therapy in patients with moderately advanced human immunodeficiency virus infection: a randomized controlled clinical trial--AIDS Clinical Trials Group 328. Arch Intern Med. 2007 Mar 26; 167(6):597-605.
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Further evidence for BRCA1 communication with the inactive X chromosome. Cell. 2007 Mar 09; 128(5):991-1002.
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Phase II study of CT-2103 as first- or second-line chemotherapy in patients with metastatic breast cancer: unexpected incidence of hypersensitivity reactions. Invest New Drugs. 2007 Aug; 25(4):369-75.
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Molecular definition of breast tumor heterogeneity. Cancer Cell. 2007 Mar; 11(3):259-73.
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Predictors of resistance to preoperative trastuzumab and vinorelbine for HER2-positive early breast cancer. Clin Cancer Res. 2007 Feb 15; 13(4):1198-207.
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Variability among breast radiation oncologists in delineation of the postsurgical lumpectomy cavity. Int J Radiat Oncol Biol Phys. 2007 Apr 01; 67(5):1299-308.
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Rebeccamycin analog for refractory breast cancer: a randomized phase II trial of dosing schedules. Invest New Drugs. 2007 Apr; 25(2):161-4.
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Germinal center function in the spleen during simian HIV infection in rhesus monkeys. J Immunol. 2006 Jul 15; 177(2):1108-19.
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Combination therapy with gefitinib and capecitabine in metastatic breast cancer (MBC): A phase I trial. J Clin Oncol. 2006 Jun 20; 24(18_suppl):10564.
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Trastuzumab and vinorelbine or taxane chemotherapy for HER2+ metastatic breast cancer: The TRAVIOTA study. J Clin Oncol. 2006 Jun 20; 24(18_suppl):650.
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A prospective study of conservative surgery without radiation therapy in select patients with Stage I breast cancer. Int J Radiat Oncol Biol Phys. 2006 Jul 15; 65(4):1149-54.
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Combined cDNA array comparative genomic hybridization and serial analysis of gene expression analysis of breast tumor progression. Cancer Res. 2006 Apr 15; 66(8):4065-78.
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Characterization of lymphocytic infiltrates in progressive multifocal leukoencephalopathy: co-localization of CD8(+) T cells with JCV-infected glial cells. J Neurovirol. 2006 Apr; 12(2):116-28.
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Prospective study of wide excision alone for ductal carcinoma in situ of the breast. J Clin Oncol. 2006 Mar 01; 24(7):1031-6.
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A putative role for psoriasin in breast tumor progression. Cancer Res. 2005 Dec 15; 65(24):11326-34.
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Dose density in breast cancer: a simple message? J Natl Cancer Inst. 2005 Dec 07; 97(23):1712-4.
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Quality of life in a clinical trial of highly active antiretroviral therapy alone or with intravenous or subcutaneous interleukin-2 administration. J Acquir Immune Defic Syndr. 2005 Dec 01; 40(4):428-33.
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Efficacy of pegfilgrastim and darbepoetin alfa as hematopoietic support for dose-dense every-2-week adjuvant breast cancer chemotherapy. J Clin Oncol. 2005 Nov 20; 23(33):8340-7.
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HIN-1, an inhibitor of cell growth, invasion, and AKT activation. Cancer Res. 2005 Nov 01; 65(21):9659-69.
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Prospective evaluation of concurrent paclitaxel and radiation therapy after adjuvant doxorubicin and cyclophosphamide chemotherapy for Stage II or III breast cancer. Int J Radiat Oncol Biol Phys. 2006 Feb 01; 64(2):496-504.
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Effect of CD8+ lymphocyte depletion on virus containment after simian immunodeficiency virus SIVmac251 challenge of live attenuated SIVmac239delta3-vaccinated rhesus macaques. J Virol. 2005 Jul; 79(13):8131-41.
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Antigen-specific T-cell memory is preserved in children treated for acute lymphoblastic leukemia. Blood. 2005 Sep 01; 106(5):1749-54.
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Vaccine-elicited memory cytotoxic T lymphocytes contribute to Mamu-A*01-associated control of simian/human immunodeficiency virus 89.6P replication in rhesus monkeys. J Virol. 2005 Apr; 79(8):4580-8.
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Sequencing of chemotherapy and radiation therapy in early-stage breast cancer: updated results of a prospective randomized trial. J Clin Oncol. 2005 Mar 20; 23(9):1934-40.
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Offering participants results of a clinical trial: sharing results of a negative study. Lancet. 2005 Mar 12-18; 365(9463):963-4.
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Prognosis after local recurrence after conservative surgery and radiation for early-stage breast cancer. Int J Radiat Oncol Biol Phys. 2005 Feb 01; 61(2):348-57.
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Serum levels of matrix extracellular phosphoglycoprotein (MEPE) in normal humans correlate with serum phosphorus, parathyroid hormone and bone mineral density. J Clin Endocrinol Metab. 2004 Aug; 89(8):4158-61.
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Recombinant poxvirus boosting of DNA-primed rhesus monkeys augments peak but not memory T lymphocyte responses. Proc Natl Acad Sci U S A. 2004 Jul 27; 101(30):11088-93.
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Rebeccamycin analog for refractory breast cancer: a randomized phase II trial. J Clin Oncol. 2004 Jul 15; 22(14_suppl):547.
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Heterologous envelope immunogens contribute to AIDS vaccine protection in rhesus monkeys. J Virol. 2004 Jul; 78(14):7490-7.
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Outcome after breast-conserving therapy for patients with stage I or II mucinous, medullary, or tubular breast carcinoma. Int J Radiat Oncol Biol Phys. 2004 May 01; 59(1):152-9.
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Daily low-dose subcutaneous interleukin-2 added to single- or dual-nucleoside therapy in HIV infection does not protect against CD4+ T-cell decline or improve other indices of immune function: results of a randomized controlled clinical trial (ACTG 248). J Acquir Immune Defic Syndr. 2004 May 01; 36(1):576-87.
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Oncology physician and nurse practices and attitudes regarding offering clinical trial results to study participants. J Natl Cancer Inst. 2004 Apr 21; 96(8):629-32.
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A prospective study of concurrent cyclophosphamide/methotrexate/5-fluorouracil and reduced-dose radiotherapy in patients with early-stage breast carcinoma. Cancer. 2004 Apr 01; 100(7):1358-64.
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Lymphocyte subsets in healthy children from birth through 18 years of age: the Pediatric AIDS Clinical Trials Group P1009 study. J Allergy Clin Immunol. 2003 Nov; 112(5):973-80.
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A neural survival factor is a candidate oncogene in breast cancer. Proc Natl Acad Sci U S A. 2003 Sep 16; 100(19):10931-6.
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Trastuzumab and vinorelbine as first-line therapy for HER2-overexpressing metastatic breast cancer: multicenter phase II trial with clinical outcomes, analysis of serum tumor markers as predictive factors, and cardiac surveillance algorithm. J Clin Oncol. 2003 Aug 01; 21(15):2889-95.
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Central nervous system metastases in women who receive trastuzumab-based therapy for metastatic breast carcinoma. Cancer. 2003 Jun 15; 97(12):2972-7.
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Lack of HIN-1 methylation in BRCA1-linked and "BRCA1-like" breast tumors. Cancer Res. 2003 May 01; 63(9):2024-7.
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Complementary medicine use among women enrolled in a genetic testing program. Cancer Epidemiol Biomarkers Prev. 2003 Apr; 12(4):321-6.
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Do patients participating in clinical trials want to know study results? J Natl Cancer Inst. 2003 Mar 19; 95(6):491-2.
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Molecular markers in ductal carcinoma in situ of the breast. Mol Cancer Res. 2003 Mar; 1(5):362-75.
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Effect of humoral immune responses on controlling viremia during primary infection of rhesus monkeys with simian immunodeficiency virus. J Virol. 2003 Feb; 77(3):2165-73.
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Preoperative therapy with trastuzumab and paclitaxel followed by sequential adjuvant doxorubicin/cyclophosphamide for HER2 overexpressing stage II or III breast cancer: a pilot study. J Clin Oncol. 2003 Jan 01; 21(1):46-53.
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BRCA1/2 genetic testing in the community setting. J Clin Oncol. 2002 Nov 15; 20(22):4485-92.
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Effect of etanercept (Enbrel) on interleukin 6, tumor necrosis factor alpha, and markers of immune activation in HIV-infected subjects receiving interleukin 2. AIDS Res Hum Retroviruses. 2002 Jun 10; 18(9):661-5.
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Understanding the basis of CD4(+) T-cell depletion in macaques infected by a simian-human immunodeficiency virus. Vaccine. 2002 May 06; 20(15):1934-7.
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Use of CD45 gating in three and four-color flow cytometric immunophenotyping: guideline from the National Institute of Allergy and Infectious Diseases, Division of AIDS. Cytometry. 2002 Apr 15; 50(2):46-52.
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Second nonbreast malignancies after conservative surgery and radiation therapy for early-stage breast cancer. Int J Radiat Oncol Biol Phys. 2002 Feb 01; 52(2):406-14.
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Respiratory maneuvers decrease irradiated cardiac volume in patients with left-sided breast cancer. J Cardiovasc Magn Reson. 2002; 4(2):265-71.
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Membrane-fusing capacity of the human immunodeficiency virus envelope proteins determines the efficiency of CD+ T-cell depletion in macaques infected by a simian-human immunodeficiency virus. J Virol. 2001 Jun; 75(12):5646-55.
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Clinical activity of trastuzumab and vinorelbine in women with HER2-overexpressing metastatic breast cancer. J Clin Oncol. 2001 May 15; 19(10):2722-30.
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Control of viremia and prevention of clinical AIDS in rhesus monkeys by cytokine-augmented DNA vaccination. Science. 2000 Oct 20; 290(5491):486-92.
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Is radiation alone adequate treatment to the axilla for patients with limited axillary surgery? Implications for treatment after a positive sentinel node biopsy. Int J Radiat Oncol Biol Phys. 2000 Aug 01; 48(1):125-32.
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Domain specificity and variability in cognitive development. Child Dev. 2000 Jul-Aug; 71(4):854-6; discussion 860-1.
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Multisite comparison of methods for the quantitation of the surface expression of CD38 on CD8(+) T lymphocytes. The ACTG Advanced Flow Cytometry Focus Group. Cytometry. 2000 Jun 15; 42(3):174-9.
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Outcome at 8 years after breast-conserving surgery and radiation therapy for invasive breast cancer: influence of margin status and systemic therapy on local recurrence. J Clin Oncol. 2000 Apr; 18(8):1668-75.
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Analyses of quality assessment studies using CD45 for gating lymphocytes for CD3(+)4(+)%. Cytometry. 2000 Feb 15; 42(1):1-4.
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Prevalence of germline truncating mutations in ATM in women with a second breast cancer after radiation therapy for a contralateral tumor. Genes Chromosomes Cancer. 2000 Feb; 27(2):124-9.
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The significance of extracapsular extension of axillary lymph node metastases in early-stage breast cancer. Int J Radiat Oncol Biol Phys. 2000 Jan 01; 46(1):31-4.
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The influence of infiltrating lobular carcinoma on the outcome of patients treated with breast-conserving surgery and radiation therapy. Breast Cancer Res Treat. 2000 Jan; 59(1):49-54.
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Factors associated with regional nodal failure in patients with early stage breast cancer with 0-3 positive axillary nodes following tangential irradiation alone. Int J Radiat Oncol Biol Phys. 1999 Dec 01; 45(5):1157-66.
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Concurrent CMF and radiation therapy for early stage breast cancer: results of a pilot study. Int J Radiat Oncol Biol Phys. 1999 Nov 01; 45(4):877-84.
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Treatment-related toxicity from a randomized trial of the sequencing of doxorubicin and radiation therapy in patients treated for early stage breast cancer. Int J Radiat Oncol Biol Phys. 1999 Aug 01; 45(1):69-72.
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Effect of complement consumption by cobra venom factor on the course of primary infection with simian immunodeficiency virus in rhesus monkeys. AIDS Res Hum Retroviruses. 1999 Jan 20; 15(2):195-202.
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Predictors of local recurrence following excision alone for ductal carcinoma in situ. Cancer. 1999 Jan 15; 85(2):427-31.
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Monitoring therapeutic response in skeletal metastases using dual-energy x-ray absorptiometry: a prospective feasibility study in breast cancer patients. Cancer Invest. 1999; 17(8):566-74.
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Editorial comment on "the link between local recurrence and distant metastasis in human breast cancer" by Serge Koscielny and Maurice Tubiana. Int J Radiat Oncol Biol Phys. 1999 Jan 01; 43(1):7-9.
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Cardiac effects of adjuvant doxorubicin and radiation therapy in breast cancer patients. J Clin Oncol. 1998 Nov; 16(11):3493-501.
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The envelope glycoprotein ectodomains determine the efficiency of CD4+ T lymphocyte depletion in simian-human immunodeficiency virus-infected macaques. J Exp Med. 1998 Sep 21; 188(6):1159-71.
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Expression of the CD8alpha beta-heterodimer on CD8(+) T lymphocytes in peripheral blood lymphocytes of human immunodeficiency virus- and human immunodeficiency virus+ individuals. Blood. 1998 Jul 01; 92(1):198-206.
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Family history and treatment outcome in young women after breast-conserving surgery and radiation therapy for early-stage breast cancer. J Clin Oncol. 1998 Jun; 16(6):2045-51.
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A putative gene causes variability in lifespan among genotypically identical mice. Nat Genet. 1998 Jun; 19(2):114-6.
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Eastern Cooperative Oncology Group randomized trials of observation versus maintenance therapy for patients with metastatic breast cancer in complete remission following induction treatment. J Clin Oncol. 1998 May; 16(5):1669-76.
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No long-term increase in cardiac-related mortality after breast-conserving surgery and radiation therapy using modern techniques. J Clin Oncol. 1998 Apr; 16(4):1374-9.
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Variations in measurement of the iliac angle of the fetal pelvis in Down syndrome. Radiology. 1998 Mar; 206(3):846-7.
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Induction chemotherapy of dibromodulcitol, Adriamycin, vincristine, tamoxifen, and Halotestin with methotrexate in metastatic breast cancer: an Eastern Cooperative Oncology Group Study (E1181). Am J Clin Oncol. 1998 Feb; 21(1):99-104.
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Impact of respiratory maneuvers on cardiac volume within left-breast radiation portals. Circulation. 1997 Nov 18; 96(10):3269-72.
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Prediction of response to antiestrogen therapy in advanced breast cancer patients by pretreatment circulating levels of extracellular domain of the HER-2/c-neu protein. J Clin Oncol. 1997 Jul; 15(7):2518-25.
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Breast-conserving therapy for stage I-II synchronous bilateral breast carcinoma. Cancer. 1997 Apr 01; 79(7):1362-9.
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Inter- and intrainstitutional evaluation of automated volumetric capillary cytometry for the quantitation of CD4- and CD8-positive T lymphocytes in the peripheral blood of persons infected with human immunodeficiency virus. Site Investigators and the NIAID New CD4 Technologies Focus Group. Clin Diagn Lab Immunol. 1997 Mar; 4(2):173-9.
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Repetitive cycles of cyclophosphamide, thiotepa, and carboplatin intensification with peripheral-blood progenitor cells and filgrastim in advanced breast cancer patients. J Clin Oncol. 1997 Feb; 15(2):674-83.
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Pathologic margin involvement and the risk of recurrence in patients treated with breast-conserving therapy. Cancer. 1996 Nov 01; 78(9):1921-8.
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Relationship of tumor grade to other pathologic features and to treatment outcome of patients with early stage breast carcinoma treated with breast-conserving therapy. Cancer. 1996 Oct 01; 78(7):1426-31.
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The sequencing of chemotherapy and radiation therapy after conservative surgery for early-stage breast cancer. N Engl J Med. 1996 May 23; 334(21):1356-61.
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A prospective study of conservative surgery alone in the treatment of selected patients with stage I breast cancer. Cancer. 1996 Mar 15; 77(6):1094-100.
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Analysis of prostate and seminal vesicle motion: implications for treatment planning. Int J Radiat Oncol Biol Phys. 1996 Jan 15; 34(2):451-8.
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Long-term outcome following breast-conserving surgery and radiation therapy. Int J Radiat Oncol Biol Phys. 1995 Sep 30; 33(2):245-51.
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Ten-year follow-up study of premenopausal women with metastatic breast cancer: an Eastern Cooperative Oncology Group study. J Clin Oncol. 1995 Jun; 13(6):1453-8.
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Life-span, T-cell responses, and incidence of lymphomas in congenic mice. Proc Natl Acad Sci U S A. 1995 Apr 25; 92(9):3992-6.
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The relationship between microscopic margins of resection and the risk of local recurrence in patients with breast cancer treated with breast-conserving surgery and radiation therapy. Cancer. 1994 Sep 15; 74(6):1746-51.
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Relationship of patient age to pathologic features of the tumor and prognosis for patients with stage I or II breast cancer. J Clin Oncol. 1994 May; 12(5):888-94.
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Myelodysplastic syndrome and acute myeloid leukemia secondary to mitolactol treatment in patients with breast cancer. J Clin Oncol. 1994 Apr; 12(4):874-5.
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What have we learned about risk factors for local recurrence after breast-conserving surgery and irradiation? J Clin Oncol. 1994 Apr; 12(4):647-9.
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Rate of relapse following treatment for localized prostate cancer: a critical analysis of retrospective reports. Int J Radiat Oncol Biol Phys. 1994 Jan 01; 28(1):303-13.
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Reinduction with the same cytostatic treatment in patients with metastatic breast cancer: an Eastern Cooperative Oncology Group study. J Clin Oncol. 1994 Jan; 12(1):45-9.
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Guideline for flow cytometric immunophenotyping: a report from the National Institute of Allergy and Infectious Diseases, Division of AIDS. Cytometry. 1993 Oct; 14(7):702-15.
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Uses of CD4-lymphocyte count in AIDS treatment decisions. Infect Agents Dis. 1993 Oct; 2(5):304-13.
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Prediction of CD4 count from CD4 percentage: experience from three laboratories. AIDS. 1993 Jul; 7(7):933-40.
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Comparison of adjuvant chemotherapy with methotrexate and fluorouracil with and without cyclophosphamide in breast cancer patients with one to three positive axillary lymph nodes. J Natl Cancer Inst. 1993 May 19; 85(10):812-7.
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NIAID Division of AIDS flow cytometry quality assessment program. Ann N Y Acad Sci. 1993 Mar 20; 677:50-2.
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Assessment of the effects of instrumentation, monoclonal antibody, and fluorochrome on flow cytometric immunophenotyping: a report based on 2 years of the NIAID DAIDS flow cytometry quality assessment program. Clin Immunol Immunopathol. 1993 Feb; 66(2):150-62.
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Interobserver reproducibility in the diagnosis of ductal proliferative breast lesions using standardized criteria. Am J Surg Pathol. 1992 Dec; 16(12):1133-43.
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Metastatic breast cancer: higher versus low dose maintenance treatment when only a partial response or a no change status is obtained following doxorubicin induction treatment. An Eastern Cooperative Oncology Group study. Ann Oncol. 1992 Nov; 3(9):768-70.
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Traits that influence longevity in mice: a second look. Genetics. 1992 Sep; 132(1):229-39.
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Preverbal and verbal counting and computation. Cognition. 1992 Aug; 44(1-2):43-74.
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Lymphocyte subsets in healthy children during the first 5 years of life. JAMA. 1992 Mar 18; 267(11):1484-8.
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Recurrence in the breast following conservative surgery and radiation therapy for early-stage breast cancer. J Natl Cancer Inst Monogr. 1992; (11):33-9.
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Statistical methods for early breast cancer trials. Cancer Treat Res. 1992; 60:27-53.
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Factors predicting for response, time to treatment failure, and survival in women with metastatic breast cancer treated with DAVTH: a prospective Eastern Cooperative Oncology Group study. J Clin Oncol. 1991 Dec; 9(12):2153-61.
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Integration of conservative surgery, radiotherapy, and chemotherapy for the treatment of early-stage, node-positive breast cancer: sequencing, timing, and outcome. J Clin Oncol. 1991 Sep; 9(9):1662-7.
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Variables associated with the development of complications from radiosurgery of intracranial tumors. Int J Radiat Oncol Biol Phys. 1991 Aug; 21(3):591-9.
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Making cocktails versus making soup. J Clin Oncol. 1991 Feb; 9(2):200-3.
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Diaphragmatic rupture due to blunt trauma: sensitivity of plain chest radiographs. AJR Am J Roentgenol. 1991 Jan; 156(1):51-7.
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Survival of premenopausal women with metastatic breast cancer. Long-term follow-up of Eastern Cooperative Group and Cancer and Leukemia Group B studies. Cancer. 1990 Oct 01; 66(7):1621-9.
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Nuclear binding of the estrogen receptor: a potential predictor for hormone response in metastatic breast cancer. Breast Cancer Res Treat. 1990 Oct; 16(3):273-8.
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Keeping an open mind about the doses of chemotherapy. J Natl Cancer Inst. 1990 Sep 19; 82(18):1446-7.
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Treatment of breast cancer in elderly patients. Lancet. 1990 Sep 01; 336(8714):564.
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Early breast cancer: predictors of breast recurrence for patients treated with conservative surgery and radiation therapy. Radiother Oncol. 1990 Sep; 19(1):29-41.
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Numerical abstraction by human infants. Cognition. 1990 Aug; 36(2):97-127.
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Genetics of survival in mice: subregions of the major histocompatibility complex. Genetics. 1990 May; 125(1):167-74.
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Improved methodology for analyzing local and distant recurrence. J Clin Oncol. 1990 Mar; 8(3):548-55.
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The what and how of counting. Cognition. 1990 Feb; 34(2):197-9.
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The presence of an extensive intraductal component following a limited excision correlates with prominent residual disease in the remainder of the breast. J Clin Oncol. 1990 Jan; 8(1):113-8.
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Can the clinical and mammographic findings at presentation predict the presence of an extensive intraductal component in early stage breast cancer? Int J Radiat Oncol Biol Phys. 1989 Dec; 17(6):1217-21.
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Mammography in symptomatic and asymptomatic patients. Hematol Oncol Clin North Am. 1989 Dec; 3(4):611-40.
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Complementary versus contrastive classification in preschool children. J Exp Child Psychol. 1989 Dec; 48(3):410-22.
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Can sonographers reliably identify anatomic features associated with Down syndrome in fetuses? Radiology. 1989 Nov; 173(2):377-80.
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The predictors of distant relapse following conservative surgery and radiotherapy for early breast cancer are similar to those following mastectomy. Int J Radiat Oncol Biol Phys. 1989 Oct; 17(4):755-60.
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Premenopausal breast cancer patients treated with conservative surgery, radiotherapy and adjuvant chemotherapy have a low risk of local failure. Int J Radiat Oncol Biol Phys. 1989 Oct; 17(4):711-7.
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A quality-of-life-oriented endpoint for comparing therapies. Biometrics. 1989 Sep; 45(3):781-95.
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Myelodysplastic syndrome and acute nonlymphocytic leukemia secondary to mitolactol treatment in patients with breast cancer. J Clin Oncol. 1989 Sep; 7(9):1252-9.
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Biostatistical considerations for quality assessment of immunologic measurements used in clinical and longitudinal studies. Clin Immunol Immunopathol. 1989 Jul; 52(1):28-37.
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Results of the flow cytometry ACTG quality control program: analysis and findings. Clin Immunol Immunopathol. 1989 Jul; 52(1):68-84.
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Spontaneous mutation rates of tumorigenic and nontumorigenic Chinese hamster embryo fibroblast cell lines. Cancer Res. 1989 Jun 15; 49(12):3374-9.
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Sonographically estimated fetal weights: accuracy and limitation. Am J Obstet Gynecol. 1988 Nov; 159(5):1118-21.
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Dose-response in the treatment of breast cancer: a critical review. J Clin Oncol. 1988 Sep; 6(9):1501-15.
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Time-course of local recurrence following conservative surgery and radiotherapy for early stage breast cancer. Int J Radiat Oncol Biol Phys. 1988 Aug; 15(2):255-61.
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Comparison of CA15-3 and carcinoembryonic antigen in monitoring the clinical course of patients with metastatic breast cancer. Cancer Res. 1988 Jul 15; 48(14):4107-12.
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Murine chromosomal regions correlated with longevity. Genetics. 1988 Apr; 118(4):693-704.
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Is mammography painful? A multicenter patient survey. Arch Intern Med. 1988 Mar; 148(3):521-4.
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Sonographic identification of second-trimester fetuses with Down's syndrome. N Engl J Med. 1987 Nov 26; 317(22):1371-6.
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The 5-year results of a randomized trial of adjuvant radiation therapy after chemotherapy in breast cancer patients treated with mastectomy. J Clin Oncol. 1987 Oct; 5(10):1546-55.
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Actual versus ideal weight in the calculation of surface area: effects on dose of 11 chemotherapy agents. Cancer Treat Rep. 1987 Oct; 71(10):907-11.
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Cardiac disease after mediastinal irradiation for seminoma. Cancer. 1987 Aug 15; 60(4):772-6.
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Second malignancies from adjuvant chemotherapy? Too soon to tell. J Clin Oncol. 1987 Aug; 5(8):1135-7.
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Treatment of metastatic breast cancer in premenopausal women using CAF with or without oophorectomy: an Eastern Cooperative Oncology Group Study. J Clin Oncol. 1987 Jun; 5(6):881-9.
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Young children's understanding of random phenomena. Child Dev. 1986 Jun; 57(3):559-66.
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Age as a prognostic factor in recurrent breast cancer. J Clin Oncol. 1986 May; 4(5):663-71.
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Combination chemotherapy compared to tamoxifen as initial therapy for stage IV breast cancer in elderly women. Ann Intern Med. 1986 Apr; 104(4):455-61.
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Duration of therapy in adjuvant chemotherapy trials. NCI Monogr. 1986; (1):95-8.
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Assessment of adjuvant trials in breast cancer. NCI Monogr. 1986; (1):11-7.
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Clinical comparison of two radiocolloids for internal mammary lymphoscintigraphy. J Nucl Med. 1985 Dec; 26(12):1382-5.
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Analysis and interpretation of the comparison of survival by treatment outcome variables in cancer clinical trials. Cancer Treat Rep. 1985 Oct; 69(10):1139-46.
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Intracranial germ-cell tumors: natural history and pathogenesis. J Neurosurg. 1985 Aug; 63(2):155-67.
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The Eastern Cooperative Oncology Group experience with cyclophosphamide, adriamycin, and 5-fluorouracil (CAF) in patients with metastatic breast cancer. Cancer. 1985 Jul 15; 56(2):219-24.
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Mitomycin and tamoxifen versus mitolactol, doxorubicin, and tamoxifen in patients with previously treated breast cancer. Cancer Treat Rep. 1985 Jul-Aug; 69(7-8):755-60.
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Comparison of CAF versus CMFP in metastatic breast cancer: analysis of prognostic factors. J Clin Oncol. 1985 Jul; 3(7):932-40.
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Cyclophosphamide, methotrexate, and 5-fluorouracil chemotherapy in women more than 65 years old with advanced breast cancer: the elimination of age trends in toxicity by using doses based on creatinine clearance. J Clin Oncol. 1984 Dec; 2(12):1404-13.
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Traits that influence longevity in mice. Genetics. 1984 Dec; 108(4):999-1011.
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Pulmonary uptake of technetium 99m macroaggregated albumin: a predictor of gastrointestinal toxicity during hepatic artery perfusion. J Clin Oncol. 1984 Nov; 2(11):1266-9.
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Utility of differential leukocyte counts in cancer management. JAMA. 1984 Sep 14; 252(10):1312-4.
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Dietary seaweed (Laminaria) and mammary carcinogenesis in rats. Cancer Res. 1984 Jul; 44(7):2758-61.
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The effect of thyroid hormone administration upon survival in patients with differentiated thyroid carcinoma. Surgery. 1983 Dec; 94(6):978-83.
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Preschoolers' counting: principles before skill. Cognition. 1983 May; 13(3):343-59.
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Management of locally advanced carcinoma of the breast by primary radiation therapy. Int J Radiat Oncol Biol Phys. 1983 Mar; 9(3):345-9.
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Prospective evaluation of rotating chemotherapy in advanced breast cancer. An Eastern Cooperative Oncology Group Trial. Am J Clin Oncol. 1983 Feb; 6(1):1-18.
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Sounding board. Fibrocystic "disease" of the breast--a nondisease? N Engl J Med. 1982 Oct 14; 307(16):1010-4.
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Comparison of induction chemotherapies for metastatic breast cancer. An Eastern Cooperative Oncology Group Trial. Cancer. 1982 Oct 01; 50(7):1235-44.
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Tamoxifen and aminoglutethimide in advanced breast cancer. Cancer Res. 1982 Aug; 42(8 Suppl):3409s-3414s.
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Randomized evaluation of combination chemotherapy vs. observation alone following response or stabilization after oophorectomy for metastatic breast cancer in premenopausal women. Am J Clin Oncol. 1982 Jun; 5(3):253-9.
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Effects of reporting lags on interim inferences from clinical trials. Experientia Suppl. 1982; 41:175-86.
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Fads and fashions of early breast cancer clinical trials in the United States over the past decade (1971-1981). Experientia Suppl. 1982; 41:520-41.
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Quality control for estrogen receptor quantification by dextran-coated charcoal assay: a single laboratory's experience. Breast Cancer Res Treat. 1982; 2(1):111-7.
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Corrected group prognostic curves and summary statistics. J Chronic Dis. 1982; 35(8):669-74.
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Phase II trials of Baker's antifol, bleomycin, CCNU, streptozotocin, tilorone, and 5-fluorodeoxyuridine plus arabinosyl cytosine in metastatic breast cancer. Cancer. 1981 Aug 01; 48(3):681-5.
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Prolonged cryopreservation of human bone marrow. Transplantation. 1981 Jun; 31(6):454-7.
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Prolonged disease-free survival in advanced breast cancer treated with "super-CMF" adriamycin: an alternating regimen employing high-dose methotrexate with citrovorum factor rescue. Cancer Treat Rep. 1981; 65 Suppl 1:67-75.
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Adriamycin plus vincristine alone or with dibromodulcitol or ICRF-159 in metastatic breast cancer. Cancer Clin Trials. 1981; 4(3):253-60.
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Relationship between time to treatment failure and survival and between time to response and response duration in metastatic breast cancer. Implications for treatment. Cancer Clin Trials. 1981; 4(4):355-62.
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A prospective evaluation of chemohormonal therapy remission maintenance in advanced breast cancer. Breast Cancer Res Treat. 1981; 1(2):111-9.
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Preschoolers' understanding of simple object transformations. Child Dev. 1980 Sep; 51(3):691-9.
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Combination chemotherapy with adriamycin-cyclophosphamide for advanced ovarian carcinoma. Cancer. 1980 Aug 15; 46(4):669-74.
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Serum long-chain alcohol levels in healthy individuals and in patients with breast cancer. Oncology. 1979; 36(3):144-7.
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The nature and development of early number concepts. Adv Child Dev Behav. 1972; 7:115-67.
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Attention in discrimination learning of young children. J Exp Child Psychol. 1966 Sep; 4(1):9-19.
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