Skip Navigation

Coronavirus (COVID-19) information for Dana-Farber patients & families Learn more

Sarah Johnstone, MD, PhD


Pathology

No Ratings Available - Why Not? Make an Appointment

Sarah Johnstone, MD, PhD

Physician

Clinical Interests

  • Gynecologic pathology

Contact Information

  • Office Phone Number857-215-1639

Bio

Dr. Johnstone received her Ph.D. from the Massachusetts Institute of Technology in 2008 and graduated from Johns Hopkins School of Medicine in 2012.  She completed her Anatomic Pathology residency and gynecologic pathology fellowship at the Massachusetts General Hospital.  She is a member of the faculty in the Department of Oncologic Pathology at the Dana-Farber Cancer Institute.  

Board Certification:

  • Anatomic Pathology

Residency:

  • Massachusetts General Hospital

Medical School:

  • Johns Hopkins School of Medicine

Research

The Johnstone Lab is focused on understanding how alterations of chromatin structure and nuclear architecture arise and impact tumor cells.  We employ advanced genomics approaches and high resolution imaging based approaches to study both engineered tumor models and primary tumor samples.  

Polycomb-lamina antagonism partitions heterochromatin at the nuclear periphery. Nat Commun. 2022 07 20; 13(1):4199.
View in: PubMed

Data-Driven Polymer Model for Mechanistic Exploration of Diploid Genome Organization. Biophys J. 2020 11 03; 119(9):1905-1916.
View in: PubMed

Large-Scale Topological Changes Restrain Malignant Progression in Colorectal Cancer. Cell. 2020 09 17; 182(6):1474-1489.e23.
View in: PubMed

Prognostic Value of Myogenic Differentiation in Dedifferentiated Liposarcoma. Am J Surg Pathol. 2020 06; 44(6):799-804.
View in: PubMed

Altered chromosomal topology drives oncogenic programs in SDH-deficient GISTs. Nature. 2019 11; 575(7781):229-233.
View in: PubMed

Altered chromosomal topology drives oncogenic programs in SDH-deficient GIST. Nature. 2019 Oct 16.
View in: PubMed

Genomic Analysis of Posterior Fossa Meningioma Demonstrates Frequent AKT1 E17K Mutations in Foramen Magnum Meningiomas. J Neurol Surg B Skull Base. 2019 Dec; 80(6):562-567.
View in: PubMed

Cohesin Loss Eliminates All Loop Domains. Cell. 2017 Oct 05; 171(2):305-320.e24.
View in: PubMed

A DNA hypermethylation module for the stem/progenitor cell signature of cancer. Genome Res. 2012 May; 22(5):837-49.
View in: PubMed

Stress and the epigenetic landscape: a link to the pathobiology of human diseases? Nat Rev Genet. 2010 Nov; 11(11):806-12.
View in: PubMed

Connecting microRNA genes to the core transcriptional regulatory circuitry of embryonic stem cells. Cell. 2008 Aug 08; 134(3):521-33.
View in: PubMed

Tcf3 is an integral component of the core regulatory circuitry of embryonic stem cells. Genes Dev. 2008 Mar 15; 22(6):746-55.
View in: PubMed

Control of developmental regulators by Polycomb in human embryonic stem cells. Cell. 2006 Apr 21; 125(2):301-13.
View in: PubMed

Chromatin immunoprecipitation and microarray-based analysis of protein location. Nat Protoc. 2006; 1(2):729-48.
View in: PubMed

Core transcriptional regulatory circuitry in human embryonic stem cells. Cell. 2005 Sep 23; 122(6):947-56.
View in: PubMed

Gene families from the Arabidopsis thaliana pollen coat proteome. Science. 2001 Jun 29; 292(5526):2482-5.
View in: PubMed

Location

Dana-Farber Cancer Institute
440 Brookline Avenue
Mayer 622B
Boston, MA 02215
Get Directions

Top