Sarah Johnstone, MD, PhD

Sarah Johnstone, MD, PhD

Contact Information

Office Phone Number

2151639

Biography

Sarah Johnstone, MD, PhD

Dr. Johnstone received her Ph.D. from the Massachusetts Institute of Technology in 2008 and graduated from Johns Hopkins School of Medicine in 2012.  She completed her Anatomic Pathology residency and gynecologic pathology fellowship at the Massachusetts General Hospital.  She is a member of the faculty in the Department of Oncologic Pathology at the Dana-Farber Cancer Institute.  

Clinical Interests

Gynecologic pathology

Board Certification

  • Anatomic Pathology

Residency

  • Massachusetts General Hospital

Medical School

  • Johns Hopkins School of Medicine

Research

    The Johnstone Lab is focused on understanding how alterations of chromatin structure and nuclear architecture arise and impact tumor cells.  We employ advanced genomics approaches and high resolution imaging based approaches to study both engineered tumor models and primary tumor samples.  

    Publications

      • Modeling epigenetic lesions that cause gliomas. Cell. 2023 08 17; 186(17):3674-3685.e14. View in: Pubmed

      • Impact of supraphysiologic MDM2 expression on chromatin networks and therapeutic responses in sarcoma. Cell Genom. 2023 Jul 12; 3(7):100321. View in: Pubmed

      • Epigenetic clocks, aging, and cancer. Science. 2022 Dec 23; 378(6626):1276-1277. View in: Pubmed

      • Polycomb-lamina antagonism partitions heterochromatin at the nuclear periphery. Nat Commun. 2022 07 20; 13(1):4199. View in: Pubmed

      • Data-Driven Polymer Model for Mechanistic Exploration of Diploid Genome Organization. Biophys J. 2020 11 03; 119(9):1905-1916. View in: Pubmed

      • Large-Scale Topological Changes Restrain Malignant Progression in Colorectal Cancer. Cell. 2020 09 17; 182(6):1474-1489.e23. View in: Pubmed

      • Prognostic Value of Myogenic Differentiation in Dedifferentiated Liposarcoma. Am J Surg Pathol. 2020 06; 44(6):799-804. View in: Pubmed

      • Altered chromosomal topology drives oncogenic programs in SDH-deficient GISTs. Nature. 2019 11; 575(7781):229-233. View in: Pubmed

      • Altered chromosomal topology drives oncogenic programs in SDH-deficient GIST. Nature. 2019 Oct 16. View in: Pubmed

      • Genomic Analysis of Posterior Fossa Meningioma Demonstrates Frequent AKT1 E17K Mutations in Foramen Magnum Meningiomas. J Neurol Surg B Skull Base. 2019 Dec; 80(6):562-567. View in: Pubmed

      • Cohesin Loss Eliminates All Loop Domains. Cell. 2017 Oct 05; 171(2):305-320.e24. View in: Pubmed

      • A DNA hypermethylation module for the stem/progenitor cell signature of cancer. Genome Res. 2012 May; 22(5):837-49. View in: Pubmed

      • Stress and the epigenetic landscape: a link to the pathobiology of human diseases? Nat Rev Genet. 2010 Nov; 11(11):806-12. View in: Pubmed

      • Connecting microRNA genes to the core transcriptional regulatory circuitry of embryonic stem cells. Cell. 2008 Aug 08; 134(3):521-33. View in: Pubmed

      • Tcf3 is an integral component of the core regulatory circuitry of embryonic stem cells. Genes Dev. 2008 Mar 15; 22(6):746-55. View in: Pubmed

      • Control of developmental regulators by Polycomb in human embryonic stem cells. Cell. 2006 Apr 21; 125(2):301-13. View in: Pubmed

      • Chromatin immunoprecipitation and microarray-based analysis of protein location. Nat Protoc. 2006; 1(2):729-48. View in: Pubmed

      • Strong solute-solute dispersive interactions in a protein-ligand complex. J Am Chem Soc. 2005 Dec 07; 127(48):17061-7. View in: Pubmed

      • Core transcriptional regulatory circuitry in human embryonic stem cells. Cell. 2005 Sep 23; 122(6):947-56. View in: Pubmed

      • Gene families from the Arabidopsis thaliana pollen coat proteome. Science. 2001 Jun 29; 292(5526):2482-5. View in: Pubmed

      Locations

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      Dana-Farber Cancer Institute

      440 Brookline Avenue Mayer 622B Boston, MA 02215
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      Dana-Farber Cancer Institute

      Location Avtar

      Dana-Farber Cancer Institute

      440 Brookline Avenue Mayer 622B Boston, MA 02215
      Get Direction
      42.3382, -71.1078

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