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Sarah Johnstone, MD, PhD


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Sarah Johnstone, MD, PhD


Clinical Interests

  • Gynecologic pathology

Contact Information

  • Office Phone Number857-215-1639


Dr. Johnstone received her Ph.D. from the Massachusetts Institute of Technology in 2008 and graduated from Johns Hopkins School of Medicine in 2012.  She completed her Anatomic Pathology residency and gynecologic pathology fellowship at the Massachusetts General Hospital.  She is a member of the faculty in the Department of Oncologic Pathology at the Dana-Farber Cancer Institute.  

Board Certification:

  • Anatomic Pathology


  • Massachusetts General Hospital

Medical School:

  • Johns Hopkins School of Medicine


The Johnstone Lab is focused on understanding how alterations of chromatin structure and nuclear architecture arise and impact tumor cells.  We employ advanced genomics approaches and high resolution imaging based approaches to study both engineered tumor models and primary tumor samples.  

Polycomb-lamina antagonism partitions heterochromatin at the nuclear periphery. Nat Commun. 2022 07 20; 13(1):4199.
View in: PubMed

Data-Driven Polymer Model for Mechanistic Exploration of Diploid Genome Organization. Biophys J. 2020 11 03; 119(9):1905-1916.
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Large-Scale Topological Changes Restrain Malignant Progression in Colorectal Cancer. Cell. 2020 09 17; 182(6):1474-1489.e23.
View in: PubMed

Prognostic Value of Myogenic Differentiation in Dedifferentiated Liposarcoma. Am J Surg Pathol. 2020 06; 44(6):799-804.
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Altered chromosomal topology drives oncogenic programs in SDH-deficient GISTs. Nature. 2019 11; 575(7781):229-233.
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Altered chromosomal topology drives oncogenic programs in SDH-deficient GIST. Nature. 2019 Oct 16.
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Genomic Analysis of Posterior Fossa Meningioma Demonstrates Frequent AKT1 E17K Mutations in Foramen Magnum Meningiomas. J Neurol Surg B Skull Base. 2019 Dec; 80(6):562-567.
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Cohesin Loss Eliminates All Loop Domains. Cell. 2017 Oct 05; 171(2):305-320.e24.
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A DNA hypermethylation module for the stem/progenitor cell signature of cancer. Genome Res. 2012 May; 22(5):837-49.
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Stress and the epigenetic landscape: a link to the pathobiology of human diseases? Nat Rev Genet. 2010 Nov; 11(11):806-12.
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Connecting microRNA genes to the core transcriptional regulatory circuitry of embryonic stem cells. Cell. 2008 Aug 08; 134(3):521-33.
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Tcf3 is an integral component of the core regulatory circuitry of embryonic stem cells. Genes Dev. 2008 Mar 15; 22(6):746-55.
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Control of developmental regulators by Polycomb in human embryonic stem cells. Cell. 2006 Apr 21; 125(2):301-13.
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Chromatin immunoprecipitation and microarray-based analysis of protein location. Nat Protoc. 2006; 1(2):729-48.
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Core transcriptional regulatory circuitry in human embryonic stem cells. Cell. 2005 Sep 23; 122(6):947-56.
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Gene families from the Arabidopsis thaliana pollen coat proteome. Science. 2001 Jun 29; 292(5526):2482-5.
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