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Srinivas R. Viswanathan, MD, PhD

Medical Oncology

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Srinivas R. Viswanathan, MD, PhD


  • Physician
  • Assistant Professor of Medicine, Harvard Medical School


Clinical Interests

  • Genitourinary oncology
  • Prostate cancer

Contact Information

  • Appointments617-582-9725 (follow-up)
    877-332-4294 (new)
  • Office Phone Number617-632-2429
  • Fax617-632-2165

Board Certification:

  • Hematology, 2017
  • Internal Medicine, 2014
  • Medical Oncology, 2017


  • Dana-Farber/Partners CancerCare, Hematology/Oncology


  • Massachusetts General Hospital, Internal Medicine

Medical School:

  • Harvard Medical School

Recent Awards:

  • Jane C. Wright Endowed Young Investigator Award, American Society for Clinical Oncology
  • Physician Research Award, Prostate Cancer Research Program, Department of Defense
  • Young Investigator Award, Prostate Cancer Foundation


A genome-scale CRISPR screen reveals PRMT1 as a critical regulator of androgen receptor signaling in prostate cancer. Cell Rep. 2022 02 22; 38(8):110417.
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Integrative clinical and molecular characterization of translocation renal cell carcinoma. Cell Rep. 2022 01 04; 38(1):110190.
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TSC2 regulates lysosome biogenesis via a non-canonical RAGC and TFEB-dependent mechanism. Nat Commun. 2021 07 12; 12(1):4245.
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Integrative molecular characterization of sarcomatoid and rhabdoid renal cell carcinoma. Nat Commun. 2021 02 05; 12(1):808.
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Prostate cancer reactivates developmental epigenomic programs during metastatic progression. Nat Genet. 2020 08; 52(8):790-799.
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Genome-scale analysis identifies paralog lethality as a vulnerability of chromosome 1p loss in cancer. Nat Genet. 2018 07; 50(7):937-943.
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Structural Alterations Driving Castration-Resistant Prostate Cancer Revealed by Linked-Read Genome Sequencing. Cell. 2018 07 12; 174(2):433-447.e19.
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Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway. Nature. 2017 07 27; 547(7664):453-457.
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Derivation and external validation of the PLASMIC score for rapid assessment of adults with thrombotic microangiopathies: a cohort study. Lancet Haematol. 2017 Apr; 4(4):e157-e164.
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LIN28 cooperates with WNT signaling to drive invasive intestinal and colorectal adenocarcinoma in mice and humans. Genes Dev. 2015 May 15; 29(10):1074-86.
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Lin28a transgenic mice manifest size and puberty phenotypes identified in human genetic association studies. Nat Genet. 2010 Jul; 42(7):626-30.
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Gallbladder lymphoma. Med Oncol. 2011 Sep; 28(3):810-2.
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Lin28: A microRNA regulator with a macro role. Cell. 2010 Feb 19; 140(4):445-9.
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Complex N-linked glycans on Asn-89 of Kaposi sarcoma herpes virus-encoded interleukin-6 mediate optimal function by affecting cytokine protein conformation. J Biol Chem. 2009 Oct 23; 284(43):29269-82.
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A role for Lin28 in primordial germ-cell development and germ-cell malignancy. Nature. 2009 Aug 13; 460(7257):909-13.
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microRNA expression during trophectoderm specification. PLoS One. 2009 Jul 03; 4(7):e6143.
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Lin28 promotes transformation and is associated with advanced human malignancies. Nat Genet. 2009 Jul; 41(7):843-8.
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Determinants of microRNA processing inhibition by the developmentally regulated RNA-binding protein Lin28. J Biol Chem. 2008 Aug 01; 283(31):21310-4.
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Ras-MAPK signaling promotes trophectoderm formation from embryonic stem cells and mouse embryos. Nat Genet. 2008 Jul; 40(7):921-6.
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Selective blockade of microRNA processing by Lin28. Science. 2008 Apr 04; 320(5872):97-100.
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N-linked glycosylation is required for optimal function of Kaposi's sarcoma herpesvirus-encoded, but not cellular, interleukin 6. J Exp Med. 2004 Feb 16; 199(4):503-14.
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