BAF complex maintains glioma stem cells in pediatric H3K27M-glioma. Cancer Discov. 2022 Oct 28.
View in:
PubMed
Systematic profiling of conditional degron tag technologies for target validation studies. Nat Commun. 2022 09 20; 13(1):5495.
View in:
PubMed
Liquid biopsy detection of genomic alterations in pediatric brain tumors from cell-free DNA in peripheral blood, CSF, and urine. Neuro Oncol. 2022 08 01; 24(8):1352-1363.
View in:
PubMed
Publisher Correction: DNA-based copy number analysis confirms genomic evolution of PDX models. NPJ Precis Oncol. 2022 Jul 12; 6(1):50.
View in:
PubMed
Proceedings of the fifth international Molecular Pathological Epidemiology (MPE) meeting. Cancer Causes Control. 2022 Aug; 33(8):1107-1120.
View in:
PubMed
DNA-based copy number analysis confirms genomic evolution of PDX models. NPJ Precis Oncol. 2022 Apr 28; 6(1):30.
View in:
PubMed
Phosphate dysregulation via the XPR1-KIDINS220 protein complex is a therapeutic vulnerability in ovarian cancer. Nat Cancer. 2022 06; 3(6):681-695.
View in:
PubMed
Copper induces cell death by targeting lipoylated TCA cycle proteins. Science. 2022 03 18; 375(6586):1254-1261.
View in:
PubMed
Massively parallel enrichment of low-frequency alleles enables duplex sequencing at low depth. Nat Biomed Eng. 2022 03; 6(3):257-266.
View in:
PubMed
Duplex-Repair enables highly accurate sequencing, despite DNA damage. Nucleic Acids Res. 2022 01 11; 50(1):e1.
View in:
PubMed
Author Correction: Fatty acid synthesis is required for breast cancer brain metastasis. Nat Cancer. 2021 11; 2(11):1243.
View in:
PubMed
Publisher Correction: A metastasis map of human cancer cell lines. Nature. 2021 Nov; 599(7885):E7.
View in:
PubMed
Synthetic Lethal Interaction between the ESCRT Paralog Enzymes VPS4A and VPS4B in Cancers Harboring Loss of Chromosome 18q or 16q. Cell Rep. 2021 Jul 13; 36(2):109367.
View in:
PubMed
Genome-scale screens identify factors regulating tumor cell responses to natural killer cells. Nat Genet. 2021 08; 53(8):1196-1206.
View in:
PubMed
Selective Modulation of a Pan-Essential Protein as a Therapeutic Strategy in Cancer. Cancer Discov. 2021 09; 11(9):2282-2299.
View in:
PubMed
FATTY ACID SYNTHESIS IS REQUIRED FOR BREAST CANCER BRAIN METASTASIS. Nat Cancer. 2021 04; 2(4):414-428.
View in:
PubMed
A first-generation pediatric cancer dependency map. Nat Genet. 2021 04; 53(4):529-538.
View in:
PubMed
Noncanonical open reading frames encode functional proteins essential for cancer cell survival. Nat Biotechnol. 2021 06; 39(6):697-704.
View in:
PubMed
Aneuploidy renders cancer cells vulnerable to mitotic checkpoint inhibition. Nature. 2021 02; 590(7846):486-491.
View in:
PubMed
Cancer research needs a better map. Nature. 2021 01; 589(7843):514-516.
View in:
PubMed
Synthetic Lethal Interaction between the ESCRT Paralog Enzymes VPS4A and VPS4B in Cancers Harboring Loss of Chromosome 18q or 16q. Cell Rep. 2020 12 15; 33(11):108493.
View in:
PubMed
A metastasis map of human cancer cell lines. Nature. 2020 12; 588(7837):331-336.
View in:
PubMed
Multiplexed single-cell transcriptional response profiling to define cancer vulnerabilities and therapeutic mechanism of action. Nat Commun. 2020 08 27; 11(1):4296.
View in:
PubMed
Author Correction: Cas9 activates the p53 pathway and selects for p53-inactivating mutations. Nat Genet. 2020 Jul; 52(7):748-749.
View in:
PubMed
The CDK inhibitor CR8 acts as a molecular glue degrader that depletes cyclin K. Nature. 2020 09; 585(7824):293-297.
View in:
PubMed
Cas9 activates the p53 pathway and selects for p53-inactivating mutations. Nat Genet. 2020 07; 52(7):662-668.
View in:
PubMed
Sensitive Detection of Minimal Residual Disease in Patients Treated for Early-Stage Breast Cancer. Clin Cancer Res. 2020 06 01; 26(11):2556-2564.
View in:
PubMed
The Angiosarcoma Project: enabling genomic and clinical discoveries in a rare cancer through patient-partnered research. Nat Med. 2020 02; 26(2):181-187.
View in:
PubMed
Discovering the anti-cancer potential of non-oncology drugs by systematic viability profiling. Nat Cancer. 2020 02; 1(2):235-248.
View in:
PubMed
Agreement between two large pan-cancer CRISPR-Cas9 gene dependency data sets. Nat Commun. 2019 12 20; 10(1):5817.
View in:
PubMed
Author Correction: Liquid versus tissue biopsy for detecting acquired resistance and tumor heterogeneity in gastrointestinal cancers. Nat Med. 2019 Dec; 25(12):1949.
View in:
PubMed
Re-programing Chromatin with a Bifunctional LSD1/HDAC Inhibitor Induces Therapeutic Differentiation in DIPG. Cancer Cell. 2019 11 11; 36(5):528-544.e10.
View in:
PubMed
Liquid versus tissue biopsy for detecting acquired resistance and tumor heterogeneity in gastrointestinal cancers. Nat Med. 2019 09; 25(9):1415-1421.
View in:
PubMed
Small-Molecule and CRISPR Screening Converge to Reveal Receptor Tyrosine Kinase Dependencies in Pediatric Rhabdoid Tumors. Cell Rep. 2019 08 27; 28(9):2331-2344.e8.
View in:
PubMed
Small Molecule Targets TMED9 and Promotes Lysosomal Degradation to Reverse Proteinopathy. Cell. 2019 07 25; 178(3):521-535.e23.
View in:
PubMed
Structural mechanism of synergistic activation of Aurora kinase B/C by phosphorylated INCENP. Nat Commun. 2019 07 18; 10(1):3166.
View in:
PubMed
Author Correction: Mitochondrial metabolism promotes adaptation to proteotoxic stress. Nat Chem Biol. 2019 Jul; 15(7):757.
View in:
PubMed
Mitochondrial metabolism promotes adaptation to proteotoxic stress. Nat Chem Biol. 2019 07; 15(7):681-689.
View in:
PubMed
Next-generation characterization of the Cancer Cell Line Encyclopedia. Nature. 2019 05; 569(7757):503-508.
View in:
PubMed
WRN helicase is a synthetic lethal target in microsatellite unstable cancers. Nature. 2019 04; 568(7753):551-556.
View in:
PubMed
Genomic evolution of cancer models: perils and opportunities. Nat Rev Cancer. 2019 02; 19(2):97-109.
View in:
PubMed
Addendum: The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity. Nature. 2019 01; 565(7738):E5-E6.
View in:
PubMed
Protection of tissue physicochemical properties using polyfunctional crosslinkers. Nat Biotechnol. 2018 Dec 17.
View in:
PubMed
Drug and disease signature integration identifies synergistic combinations in glioblastoma. Nat Commun. 2018 12 14; 9(1):5315.
View in:
PubMed
Improved estimation of cancer dependencies from large-scale RNAi screens using model-based normalization and data integration. Nat Commun. 2018 11 02; 9(1):4610.
View in:
PubMed
Retraction Note: Selective killing of cancer cells by a small molecule targeting the stress response to ROS. Nature. 2018 09; 561(7723):420.
View in:
PubMed
Cytokine sensitivity screening highlights BMP4 pathway signaling as a therapeutic opportunity in ER+ breast cancer. FASEB J. 2019 02; 33(2):1644-1657.
View in:
PubMed
Selective gene dependencies in MYCN-amplified neuroblastoma include the core transcriptional regulatory circuitry. Nat Genet. 2018 09; 50(9):1240-1246.
View in:
PubMed
Genetic and transcriptional evolution alters cancer cell line drug response. Nature. 2018 08; 560(7718):325-330.
View in:
PubMed
Author Correction: Molecular subtypes of diffuse large B cell lymphoma are associated with distinct pathogenic mechanisms and outcomes. Nat Med. 2018 Aug; 24(8):1290-1291.
View in:
PubMed
Publisher Correction: Molecular subtypes of diffuse large B cell lymphoma are associated with distinct pathogenic mechanisms and outcomes. Nat Med. 2018 Aug; 24(8):1292.
View in:
PubMed
Molecular subtypes of diffuse large B cell lymphoma are associated with distinct pathogenic mechanisms and outcomes. Nat Med. 2018 05; 24(5):679-690.
View in:
PubMed
Developmental and oncogenic programs in H3K27M gliomas dissected by single-cell RNA-seq. Science. 2018 04 20; 360(6386):331-335.
View in:
PubMed
A Library of Phosphoproteomic and Chromatin Signatures for Characterizing Cellular Responses to Drug Perturbations. Cell Syst. 2018 Apr 25; 6(4):424-443.e7.
View in:
PubMed
Therapeutically targeting tumor microenvironment-mediated drug resistance in estrogen receptor-positive breast cancer. J Exp Med. 2018 03 05; 215(3):895-910.
View in:
PubMed
Association of Cell-Free DNA Tumor Fraction and Somatic Copy Number Alterations With Survival in Metastatic Triple-Negative Breast Cancer. J Clin Oncol. 2018 02 20; 36(6):543-553.
View in:
PubMed
High-throughput Phenotyping of Lung Cancer Somatic Mutations. Cancer Cell. 2017 12 11; 32(6):884.
View in:
PubMed
CRISPR-Cas9 screen reveals a MYCN-amplified neuroblastoma dependency on EZH2. J Clin Invest. 2018 01 02; 128(1):446-462.
View in:
PubMed
A dataset of images and morphological profiles of 30 000 small-molecule treatments using the Cell Painting assay. Gigascience. 2017 12 01; 6(12):1-5.
View in:
PubMed
Evaluation of RNAi and CRISPR technologies by large-scale gene expression profiling in the Connectivity Map. PLoS Biol. 2017 Nov; 15(11):e2003213.
View in:
PubMed
A Next Generation Connectivity Map: L1000 Platform and the First 1,000,000 Profiles. Cell. 2017 Nov 30; 171(6):1437-1452.e17.
View in:
PubMed
The Library of Integrated Network-Based Cellular Signatures NIH Program: System-Level Cataloging of Human Cells Response to Perturbations. Cell Syst. 2018 01 24; 6(1):13-24.
View in:
PubMed
Scalable whole-exome sequencing of cell-free DNA reveals high concordance with metastatic tumors. Nat Commun. 2017 11 06; 8(1):1324.
View in:
PubMed
Computational correction of copy number effect improves specificity of CRISPR-Cas9 essentiality screens in cancer cells. Nat Genet. 2017 Dec; 49(12):1779-1784.
View in:
PubMed
Common and cell-type specific responses to anti-cancer drugs revealed by high throughput transcript profiling. Nat Commun. 2017 10 30; 8(1):1186.
View in:
PubMed
Patient-derived xenografts undergo mouse-specific tumor evolution. Nat Genet. 2017 Nov; 49(11):1567-1575.
View in:
PubMed
Erratum: The microRNA miR-31 inhibits CD8+ T cell function in chronic viral infection. Nat Immunol. 2017 09 19; 18(10):1173.
View in:
PubMed
Potential role of intratumor bacteria in mediating tumor resistance to the chemotherapeutic drug gemcitabine. Science. 2017 09 15; 357(6356):1156-1160.
View in:
PubMed
A mutational signature reveals alterations underlying deficient homologous recombination repair in breast cancer. Nat Genet. 2017 Oct; 49(10):1476-1486.
View in:
PubMed
Defining a Cancer Dependency Map. Cell. 2017 Jul 27; 170(3):564-576.e16.
View in:
PubMed
Recurrent and functional regulatory mutations in breast cancer. Nature. 2017 07 06; 547(7661):55-60.
View in:
PubMed
High-throughput validation of ceRNA regulatory networks. BMC Genomics. 2017 05 30; 18(1):418.
View in:
PubMed
The microRNA miR-31 inhibits CD8+ T cell function in chronic viral infection. Nat Immunol. 2017 Jul; 18(7):791-799.
View in:
PubMed
Direct evidence for a polygenic etiology in familial multiple myeloma. Blood Adv. 2017 Apr 11; 1(10):619-623.
View in:
PubMed
The Drug Repurposing Hub: a next-generation drug library and information resource. Nat Med. 2017 04 07; 23(4):405-408.
View in:
PubMed
Decoupling genetics, lineages, and microenvironment in IDH-mutant gliomas by single-cell RNA-seq. Science. 2017 03 31; 355(6332).
View in:
PubMed
LACTB is a tumour suppressor that modulates lipid metabolism and cell state. Nature. 2017 03 30; 543(7647):681-686.
View in:
PubMed
DPP8 and DPP9 inhibition induces pro-caspase-1-dependent monocyte and macrophage pyroptosis. Nat Chem Biol. 2017 Jan; 13(1):46-53.
View in:
PubMed
Single-cell RNA-seq supports a developmental hierarchy in human oligodendroglioma. Nature. 2016 11 10; 539(7628):309-313.
View in:
PubMed
Genetic interrogation of circulating multiple myeloma cells at single-cell resolution. Sci Transl Med. 2016 11 02; 8(363):363ra147.
View in:
PubMed
334 A Functional Screen Identifies miRNAs that Induce Radioresistance in Glioblastomas. Neurosurgery. 2016 Aug; 63 Suppl 1:197-8.
View in:
PubMed
High-throughput Phenotyping of Lung Cancer Somatic Mutations. Cancer Cell. 2016 08 08; 30(2):214-228.
View in:
PubMed
Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond. PLoS Pathog. 2016 07; 12(7):e1005763.
View in:
PubMed
The landscape of chromosomal aberrations in breast cancer mouse models reveals driver-specific routes to tumorigenesis. Nat Commun. 2016 07 04; 7:12160.
View in:
PubMed
Genomic Copy Number Dictates a Gene-Independent Cell Response to CRISPR/Cas9 Targeting. Cancer Discov. 2016 08; 6(8):914-29.
View in:
PubMed
Systematic Functional Interrogation of Rare Cancer Variants Identifies Oncogenic Alleles. Cancer Discov. 2016 07; 6(7):714-26.
View in:
PubMed
miR-126 Regulates Distinct Self-Renewal Outcomes in Normal and Malignant Hematopoietic Stem Cells. Cancer Cell. 2016 Apr 11; 29(4):602-606.
View in:
PubMed
High-throughput identification of genotype-specific cancer vulnerabilities in mixtures of barcoded tumor cell lines. Nat Biotechnol. 2016 Apr; 34(4):419-23.
View in:
PubMed
MTAP deletion confers enhanced dependency on the PRMT5 arginine methyltransferase in cancer cells. Science. 2016 Mar 11; 351(6278):1214-8.
View in:
PubMed
miR-126 Regulates Distinct Self-Renewal Outcomes in Normal and Malignant Hematopoietic Stem Cells. Cancer Cell. 2016 Feb 08; 29(2):214-28.
View in:
PubMed
Corrigendum: The genomic landscape of juvenile myelomonocytic leukemia. Nat Genet. 2016 Jan; 48(1):101.
View in:
PubMed
Targetable genetic features of primary testicular and primary central nervous system lymphomas. Blood. 2016 Feb 18; 127(7):869-81.
View in:
PubMed
The genomic landscape of juvenile myelomonocytic leukemia. Nat Genet. 2015 Nov; 47(11):1326-1333.
View in:
PubMed
Comprehensive assessment of cancer missense mutation clustering in protein structures. Proc Natl Acad Sci U S A. 2015 Oct 06; 112(40):E5486-95.
View in:
PubMed
Corrigendum: Selective killing of cancer cells by a small molecule targeting the stress response to ROS. Nature. 2015 Oct 22; 526(7574):596.
View in:
PubMed
An ecosystem of cancer cell line factories to support a cancer dependency map. Nat Rev Genet. 2015 Jul; 16(7):373-4.
View in:
PubMed
Genomic Correlate of Exceptional Erlotinib Response in Head and Neck Squamous Cell Carcinoma. JAMA Oncol. 2015 May; 1(2):238-44.
View in:
PubMed
A Maltose-Binding Protein Fusion Construct Yields a Robust Crystallography Platform for MCL1. PLoS One. 2015; 10(4):e0125010.
View in:
PubMed
Expression profiles of 151 pediatric low-grade gliomas reveal molecular differences associated with location and histological subtype. Neuro Oncol. 2015 Nov; 17(11):1486-96.
View in:
PubMed
Niche-Based Screening in Multiple Myeloma Identifies a Kinesin-5 Inhibitor with Improved Selectivity over Hematopoietic Progenitors. Cell Rep. 2015 Feb 10; 10(5):755-770.
View in:
PubMed
Genetic modifiers of EGFR dependence in non-small cell lung cancer. Proc Natl Acad Sci U S A. 2014 Dec 30; 111(52):18661-6.
View in:
PubMed
Complementary genomic approaches highlight the PI3K/mTOR pathway as a common vulnerability in osteosarcoma. Proc Natl Acad Sci U S A. 2014 Dec 23; 111(51):E5564-73.
View in:
PubMed
Erratum: Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies. Sci Data. 2014; 1:140044.
View in:
PubMed
Single Diastereomer of a Macrolactam Core Binds Specifically to Myeloid Cell Leukemia 1 (MCL1). ACS Med Chem Lett. 2014 Dec 11; 5(12):1308-12.
View in:
PubMed
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies. Sci Data. 2014; 1:140035.
View in:
PubMed
A functional screen identifies miRs that induce radioresistance in glioblastomas. Mol Cancer Res. 2014 Dec; 12(12):1767-78.
View in:
PubMed
The genomic landscape of pediatric Ewing sarcoma. Cancer Discov. 2014 Nov; 4(11):1326-41.
View in:
PubMed
Toward performance-diverse small-molecule libraries for cell-based phenotypic screening using multiplexed high-dimensional profiling. Proc Natl Acad Sci U S A. 2014 Jul 29; 111(30):10911-6.
View in:
PubMed
A high-throughput, multiplexed assay for superfamily-wide profiling of enzyme activity. Nat Chem Biol. 2014 Aug; 10(8):656-63.
View in:
PubMed
LINCS Canvas Browser: interactive web app to query, browse and interrogate LINCS L1000 gene expression signatures. Nucleic Acids Res. 2014 Jul; 42(Web Server issue):W449-60.
View in:
PubMed
Whole-exome sequencing of circulating tumor cells provides a window into metastatic prostate cancer. Nat Biotechnol. 2014 May; 32(5):479-84.
View in:
PubMed
Integrated genomic analysis illustrates the central role of JAK-STAT pathway activation in myeloproliferative neoplasm pathogenesis. Blood. 2014 May 29; 123(22):e123-33.
View in:
PubMed
Epidermal growth factor receptor inhibition attenuates liver fibrosis and development of hepatocellular carcinoma. Hepatology. 2014 Apr; 59(4):1577-90.
View in:
PubMed
Widespread genetic heterogeneity in multiple myeloma: implications for targeted therapy. Cancer Cell. 2014 Jan 13; 25(1):91-101.
View in:
PubMed
Discovery and saturation analysis of cancer genes across 21 tumour types. Nature. 2014 Jan 23; 505(7484):495-501.
View in:
PubMed
Multiplex cytological profiling assay to measure diverse cellular states. PLoS One. 2013; 8(12):e80999.
View in:
PubMed
A phase II study of the EGFR inhibitor gefitinib in patients with acute myeloid leukemia. Leuk Res. 2014 Apr; 38(4):430-4.
View in:
PubMed
Niche-based screening identifies small-molecule inhibitors of leukemia stem cells. Nat Chem Biol. 2013 Dec; 9(12):840-848.
View in:
PubMed
CXCR4 pathway associated with family history of melanoma. Cancer Causes Control. 2014 Jan; 25(1):125-32.
View in:
PubMed
Tight coordination of protein translation and HSF1 activation supports the anabolic malignant state. Science. 2013 Jul 19; 341(6143):1238303.
View in:
PubMed
Mutational heterogeneity in cancer and the search for new cancer-associated genes. Nature. 2013 Jul 11; 499(7457):214-218.
View in:
PubMed
SYK inhibition modulates distinct PI3K/AKT- dependent survival pathways and cholesterol biosynthesis in diffuse large B cell lymphomas. Cancer Cell. 2013 Jun 10; 23(6):826-38.
View in:
PubMed
Punctuated evolution of prostate cancer genomes. Cell. 2013 Apr 25; 153(3):666-77.
View in:
PubMed
Exome and whole-genome sequencing of esophageal adenocarcinoma identifies recurrent driver events and mutational complexity. Nat Genet. 2013 May; 45(5):478-86.
View in:
PubMed
Prognostic gene expression signature for patients with hepatitis C-related early-stage cirrhosis. Gastroenterology. 2013 May; 144(5):1024-30.
View in:
PubMed
Expression profiling of archival tumors for long-term health studies. Clin Cancer Res. 2012 Nov 15; 18(22):6136-46.
View in:
PubMed
Dual suppression of the cyclin-dependent kinase inhibitors CDKN2C and CDKN1A in human melanoma. J Natl Cancer Inst. 2012 Nov 07; 104(21):1673-9.
View in:
PubMed
AACR Cancer Progress Report 2012. Clin Cancer Res. 2012 Nov 01; 18(21 Suppl):S1-100.
View in:
PubMed
Integrative analysis reveals an outcome-associated and targetable pattern of p53 and cell cycle deregulation in diffuse large B cell lymphoma. Cancer Cell. 2012 Sep 11; 22(3):359-72.
View in:
PubMed
Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion. Nature. 2012 Jul 26; 487(7408):500-4.
View in:
PubMed
A remarkably simple genome underlies highly malignant pediatric rhabdoid cancers. J Clin Invest. 2012 Aug; 122(8):2983-8.
View in:
PubMed
Sequence analysis of mutations and translocations across breast cancer subtypes. Nature. 2012 Jun 20; 486(7403):405-9.
View in:
PubMed
Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer. Nat Genet. 2012 May 20; 44(6):685-9.
View in:
PubMed
Melanoma genome sequencing reveals frequent PREX2 mutations. Nature. 2012 May 09; 485(7399):502-6.
View in:
PubMed
Chemical genomics identifies small-molecule MCL1 repressors and BCL-xL as a predictor of MCL1 dependency. Cancer Cell. 2012 Apr 17; 21(4):547-62.
View in:
PubMed
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity. Nature. 2012 Mar 28; 483(7391):603-7.
View in:
PubMed
Discovery and prioritization of somatic mutations in diffuse large B-cell lymphoma (DLBCL) by whole-exome sequencing. Proc Natl Acad Sci U S A. 2012 Mar 06; 109(10):3879-84.
View in:
PubMed
STK33 kinase inhibitor BRD-8899 has no effect on KRAS-dependent cancer cell viability. Proc Natl Acad Sci U S A. 2012 Feb 21; 109(8):2860-5.
View in:
PubMed
SF3B1 and other novel cancer genes in chronic lymphocytic leukemia. N Engl J Med. 2011 Dec 29; 365(26):2497-506.
View in:
PubMed
PAK1 is a breast cancer oncogene that coordinately activates MAPK and MET signaling. Oncogene. 2012 Jul 19; 31(29):3397-408.
View in:
PubMed
Analysis of genomic aberrations and gene expression profiling identifies novel lesions and pathways in myeloproliferative neoplasms. Blood Cancer J. 2011 Nov; 1(11):e40.
View in:
PubMed
Amplification of CRKL induces transformation and epidermal growth factor receptor inhibitor resistance in human non-small cell lung cancers. Cancer Discov. 2011 Dec; 1(7):608-25.
View in:
PubMed
Stem cell gene expression programs influence clinical outcome in human leukemia. Nat Med. 2011 Aug 28; 17(9):1086-93.
View in:
PubMed
The mutational landscape of head and neck squamous cell carcinoma. Science. 2011 Aug 26; 333(6046):1157-60.
View in:
PubMed
Selective killing of cancer cells by a small molecule targeting the stress response to ROS. Nature. 2011 Jul 13; 475(7355):231-4.
View in:
PubMed
Humanized mice with ectopic artificial liver tissues. Proc Natl Acad Sci U S A. 2011 Jul 19; 108(29):11842-7.
View in:
PubMed
mRNA expression signature of Gleason grade predicts lethal prostate cancer. J Clin Oncol. 2011 Jun 10; 29(17):2391-6.
View in:
PubMed
Initial genome sequencing and analysis of multiple myeloma. Nature. 2011 Mar 24; 471(7339):467-72.
View in:
PubMed
MicroRNA-based classification of hepatocellular carcinoma and oncogenic role of miR-517a. Gastroenterology. 2011 May; 140(5):1618-28.e16.
View in:
PubMed
The genomic complexity of primary human prostate cancer. Nature. 2011 Feb 10; 470(7333):214-20.
View in:
PubMed
SMAD4-dependent barrier constrains prostate cancer growth and metastatic progression. Nature. 2011 Feb 10; 470(7333):269-73.
View in:
PubMed
Signatures of murine B-cell development implicate Yy1 as a regulator of the germinal center-specific program. Proc Natl Acad Sci U S A. 2011 Feb 15; 108(7):2873-8.
View in:
PubMed
Densely interconnected transcriptional circuits control cell states in human hematopoiesis. Cell. 2011 Jan 21; 144(2):296-309.
View in:
PubMed
COT drives resistance to RAF inhibition through MAP kinase pathway reactivation. Nature. 2010 Dec 16; 468(7326):968-72.
View in:
PubMed
Integrative analysis reveals selective 9p24.1 amplification, increased PD-1 ligand expression, and further induction via JAK2 in nodular sclerosing Hodgkin lymphoma and primary mediastinal large B-cell lymphoma. Blood. 2010 Oct 28; 116(17):3268-77.
View in:
PubMed
MicroRNA miR-125a controls hematopoietic stem cell number. Proc Natl Acad Sci U S A. 2010 Aug 10; 107(32):14229-34.
View in:
PubMed
Chemical genetic strategy identifies histone deacetylase 1 (HDAC1) and HDAC2 as therapeutic targets in sickle cell disease. Proc Natl Acad Sci U S A. 2010 Jul 13; 107(28):12617-22.
View in:
PubMed
Integrative genome comparison of primary and metastatic melanomas. PLoS One. 2010 May 24; 5(5):e10770.
View in:
PubMed
Chronic cisplatin treatment promotes enhanced damage repair and tumor progression in a mouse model of lung cancer. Genes Dev. 2010 Apr 15; 24(8):837-52.
View in:
PubMed
Counterpoint: Data first. Nature. 2010 Apr 01; 464(7289):679.
View in:
PubMed
The connectivity map links iron regulatory protein-1-mediated inhibition of hypoxia-inducible factor-2a translation to the anti-inflammatory 15-deoxy-delta12,14-prostaglandin J2. Cancer Res. 2010 Apr 15; 70(8):3071-9.
View in:
PubMed
Molecular sampling of prostate cancer: a dilemma for predicting disease progression. BMC Med Genomics. 2010 Mar 16; 3:8.
View in:
PubMed
The landscape of somatic copy-number alteration across human cancers. Nature. 2010 Feb 18; 463(7283):899-905.
View in:
PubMed
Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1. Cancer Cell. 2010 Jan 19; 17(1):98-110.
View in:
PubMed
Dicer1 functions as a haploinsufficient tumor suppressor. Genes Dev. 2009 Dec 01; 23(23):2700-4.
View in:
PubMed
Empirical Bayes analysis of quantitative proteomics experiments. PLoS One. 2009 Oct 14; 4(10):e7454.
View in:
PubMed
Proteomic and genetic approaches identify Syk as an AML target. Cancer Cell. 2009 Oct 06; 16(4):281-94.
View in:
PubMed
MicroRNA dynamics in the stages of tumorigenesis correlate with hallmark capabilities of cancer. Genes Dev. 2009 Sep 15; 23(18):2152-65.
View in:
PubMed
Integrative transcriptome analysis reveals common molecular subclasses of human hepatocellular carcinoma. Cancer Res. 2009 Sep 15; 69(18):7385-92.
View in:
PubMed
microRNA expression during trophectoderm specification. PLoS One. 2009 Jul 03; 4(7):e6143.
View in:
PubMed
Lin28 promotes transformation and is associated with advanced human malignancies. Nat Genet. 2009 Jul; 41(7):843-8.
View in:
PubMed
A single center experience with high-dose (HD) IL-2 treatment for patients with advanced melanoma and pilot investigation of a novel gene expression signature as a predictor of response. J Clin Oncol. 2009 May 20; 27(15_suppl):9003.
View in:
PubMed
Identification of AML1-ETO modulators by chemical genomics. Blood. 2009 Jun 11; 113(24):6193-205.
View in:
PubMed
Prolonged therapy for hepatitis C with low-dose peginterferon. N Engl J Med. 2009 Mar 12; 360(11):1152; author reply 1152-3.
View in:
PubMed
Identifying the proteins to which small-molecule probes and drugs bind in cells. Proc Natl Acad Sci U S A. 2009 Mar 24; 106(12):4617-22.
View in:
PubMed
MicroRNA-1 negatively regulates expression of the hypertrophy-associated calmodulin and Mef2a genes. Mol Cell Biol. 2009 Apr; 29(8):2193-204.
View in:
PubMed
Small-molecule inhibitors of HIF-2a translation link its 5'UTR iron-responsive element to oxygen sensing. Mol Cell. 2008 Dec 26; 32(6):838-48.
View in:
PubMed
Bead-based profiling of tyrosine kinase phosphorylation identifies SRC as a potential target for glioblastoma therapy. Nat Biotechnol. 2009 Jan; 27(1):77-83.
View in:
PubMed
Highly parallel identification of essential genes in cancer cells. Proc Natl Acad Sci U S A. 2008 Dec 23; 105(51):20380-5.
View in:
PubMed
Gene expression in fixed tissues and outcome in hepatocellular carcinoma. N Engl J Med. 2008 Nov 06; 359(19):1995-2004.
View in:
PubMed
Distinct microRNA expression profiles in acute myeloid leukemia with common translocations. Proc Natl Acad Sci U S A. 2008 Oct 07; 105(40):15535-40.
View in:
PubMed
Identification of an evolutionarily conserved transcriptional signature of CD8 memory differentiation that is shared by T and B cells. J Immunol. 2008 Aug 01; 181(3):1859-68.
View in:
PubMed
Gene expression-based survival prediction in lung adenocarcinoma: a multi-site, blinded validation study. Nat Med. 2008 Aug; 14(8):822-7.
View in:
PubMed
Expression-based screening identifies the combination of histone deacetylase inhibitors and retinoids for neuroblastoma differentiation. Proc Natl Acad Sci U S A. 2008 Jul 15; 105(28):9751-6.
View in:
PubMed
15-Hydroxyprostaglandin dehydrogenase is a target of hepatocyte nuclear factor 3beta and a tumor suppressor in lung cancer. Cancer Res. 2008 Jul 01; 68(13):5040-8.
View in:
PubMed
Id1 is a common downstream target of oncogenic tyrosine kinases in leukemic cells. Blood. 2008 Sep 01; 112(5):1981-92.
View in:
PubMed
MicroRNA-mediated control of cell fate in megakaryocyte-erythrocyte progenitors. Dev Cell. 2008 Jun; 14(6):843-53.
View in:
PubMed
Estrogen-dependent signaling in a molecularly distinct subclass of aggressive prostate cancer. J Natl Cancer Inst. 2008 Jun 04; 100(11):815-25.
View in:
PubMed
Gene expression-based screening for inhibitors of PDGFR signaling. Genome Biol. 2008; 9(3):R47.
View in:
PubMed
Large-scale chemical dissection of mitochondrial function. Nat Biotechnol. 2008 Mar; 26(3):343-51.
View in:
PubMed
Modeling genomic diversity and tumor dependency in malignant melanoma. Cancer Res. 2008 Feb 01; 68(3):664-73.
View in:
PubMed
An erythroid differentiation signature predicts response to lenalidomide in myelodysplastic syndrome. PLoS Med. 2008 Feb; 5(2):e35.
View in:
PubMed
Identification of RPS14 as a 5q- syndrome gene by RNA interference screen. Nature. 2008 Jan 17; 451(7176):335-9.
View in:
PubMed
Assessing the significance of chromosomal aberrations in cancer: methodology and application to glioma. Proc Natl Acad Sci U S A. 2007 Dec 11; 104(50):20007-12.
View in:
PubMed
MicroRNA expression signatures accurately discriminate acute lymphoblastic leukemia from acute myeloid leukemia. Proc Natl Acad Sci U S A. 2007 Dec 11; 104(50):19971-6.
View in:
PubMed
Identification of driver and passenger mutations of FLT3 by high-throughput DNA sequence analysis and functional assessment of candidate alleles. Cancer Cell. 2007 Dec; 12(6):501-13.
View in:
PubMed
Subclass mapping: identifying common subtypes in independent disease data sets. PLoS One. 2007 Nov 21; 2(11):e1195.
View in:
PubMed
Identification of prostate cancer modifier pathways using parental strain expression mapping. Proc Natl Acad Sci U S A. 2007 Nov 06; 104(45):17771-6.
View in:
PubMed
Comment on "The consensus coding sequences of human breast and colorectal cancers". Science. 2007 Sep 14; 317(5844):1500.
View in:
PubMed
Altered microRNA expression in human heart disease. Physiol Genomics. 2007 Nov 14; 31(3):367-73.
View in:
PubMed
Lesional gene expression profiling in cutaneous T-cell lymphoma reveals natural clusters associated with disease outcome. Blood. 2007 Oct 15; 110(8):3015-27.
View in:
PubMed
Integrative analysis reveals 53BP1 copy loss and decreased expression in a subset of human diffuse large B-cell lymphomas. Oncogene. 2008 Jan 10; 27(3):318-22.
View in:
PubMed
Identification of the JNK signaling pathway as a functional target of the tumor suppressor PTEN. Cancer Cell. 2007 Jun; 11(6):555-69.
View in:
PubMed
Genomics: global views of leukaemia. Nature. 2007 Apr 12; 446(7137):739-40.
View in:
PubMed
Impaired microRNA processing enhances cellular transformation and tumorigenesis. Nat Genet. 2007 May; 39(5):673-7.
View in:
PubMed
Signature-based small molecule screening identifies cytosine arabinoside as an EWS/FLI modulator in Ewing sarcoma. PLoS Med. 2007 Apr; 4(4):e122.
View in:
PubMed
Semiautomated multiplexed quantum dot-based in situ hybridization and spectral deconvolution. J Mol Diagn. 2007 Feb; 9(1):20-9.
View in:
PubMed
IFN-alpha-stimulated genes and Epstein-Barr virus gene expression distinguish WHO type II and III nasopharyngeal carcinomas. Cancer Res. 2007 Jan 15; 67(2):474-81.
View in:
PubMed
Prospective isolation and global gene expression analysis of definitive and visceral endoderm. Dev Biol. 2007 Apr 15; 304(2):541-55.
View in:
PubMed
Transcriptional profiling identifies cyclin D1 as a critical downstream effector of mutant epidermal growth factor receptor signaling. Cancer Res. 2006 Dec 01; 66(23):11389-98.
View in:
PubMed
The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease. Science. 2006 Sep 29; 313(5795):1929-35.
View in:
PubMed
Gene expression signature-based chemical genomic prediction identifies a novel class of HSP90 pathway modulators. Cancer Cell. 2006 Oct; 10(4):321-30.
View in:
PubMed
Gene expression-based chemical genomics identifies rapamycin as a modulator of MCL1 and glucocorticoid resistance. Cancer Cell. 2006 Oct; 10(4):331-42.
View in:
PubMed
Imaging of multiple mRNA targets using quantum dot based in situ hybridization and spectral deconvolution in clinical biopsies. Biochem Biophys Res Commun. 2006 Sep 22; 348(2):628-36.
View in:
PubMed
Transformation from committed progenitor to leukaemia stem cell initiated by MLL-AF9. Nature. 2006 Aug 17; 442(7104):818-22.
View in:
PubMed
MPLW515L is a novel somatic activating mutation in myelofibrosis with myeloid metaplasia. PLoS Med. 2006 Jul; 3(7):e270.
View in:
PubMed
Expression profiling of EWS/FLI identifies NKX2.2 as a critical target gene in Ewing's sarcoma. Cancer Cell. 2006 May; 9(5):405-16.
View in:
PubMed
Celastrol, Gedunin, and Derivatives Thereof as Hsp90 Inhinitors. 2006.
Increased expression of genes converting adrenal androgens to testosterone in androgen-independent prostate cancer. Cancer Res. 2006 Mar 01; 66(5):2815-25.
View in:
PubMed
Identification of distinct molecular phenotypes in acute megakaryoblastic leukemia by gene expression profiling. Proc Natl Acad Sci U S A. 2006 Feb 28; 103(9):3339-44.
View in:
PubMed
Respiratory failure due to differentiation arrest and expansion of alveolar cells following lung-specific loss of the transcription factor C/EBPalpha in mice. Mol Cell Biol. 2006 Feb; 26(3):1109-23.
View in:
PubMed
A method for high-throughput gene expression signature analysis. Genome Biol. 2006; 7(7):R61.
View in:
PubMed
Application of oligonucleotide microarrays to assess the biological effects of neoadjuvant imatinib mesylate treatment for localized prostate cancer. Clin Cancer Res. 2006 Jan 01; 12(1):152-8.
View in:
PubMed
Epstein-Barr-virus-encoded LMP2A induces primary epithelial cell migration and invasion: possible role in nasopharyngeal carcinoma metastasis. J Virol. 2005 Dec; 79(24):15430-42.
View in:
PubMed
BRAF mutation predicts sensitivity to MEK inhibition. Nature. 2006 Jan 19; 439(7074):358-62.
View in:
PubMed
Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci U S A. 2005 Oct 25; 102(43):15545-50.
View in:
PubMed
A zebrafish bmyb mutation causes genome instability and increased cancer susceptibility. Proc Natl Acad Sci U S A. 2005 Sep 13; 102(37):13194-9.
View in:
PubMed
Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma. Nature. 2005 Jul 07; 436(7047):117-22.
View in:
PubMed
Gefitinib induces myeloid differentiation of acute myeloid leukemia. Blood. 2005 Oct 15; 106(8):2841-8.
View in:
PubMed
MicroRNA expression profiles classify human cancers. Nature. 2005 Jun 09; 435(7043):834-8.
View in:
PubMed
Solution-based methods for RNA expression profiling. 2005.
NFkappaB activity, function, and target-gene signatures in primary mediastinal large B-cell lymphoma and diffuse large B-cell lymphoma subtypes. Blood. 2005 Aug 15; 106(4):1392-9.
View in:
PubMed
Androgen mediated regulation and functional implications of fkbp51 expression in prostate cancer. J Urol. 2005 May; 173(5):1772-7.
View in:
PubMed
Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis. Cancer Cell. 2005 Apr; 7(4):387-97.
View in:
PubMed
An RNA interference model of RPS19 deficiency in Diamond-Blackfan anemia recapitulates defective hematopoiesis and rescue by dexamethasone: identification of dexamethasone-responsive genes by microarray. Blood. 2005 Jun 15; 105(12):4620-6.
View in:
PubMed
Systematic discovery of regulatory motifs in human promoters and 3' UTRs by comparison of several mammals. Nature. 2005 Mar 17; 434(7031):338-45.
View in:
PubMed
Conditional MLL-CBP targets GMP and models therapy-related myeloproliferative disease. EMBO J. 2005 Jan 26; 24(2):368-81.
View in:
PubMed
Acute Myeloid Leukemia. In: Pizzo PA, Poplack DG, eds. Principles and Practice of Pediatric Oncology. 2005; 20:545-589.
An oncogenic KRAS2 expression signature identified by cross-species gene-expression analysis. Nat Genet. 2005 Jan; 37(1):48-55.
View in:
PubMed
Androgen-induced differentiation and tumorigenicity of human prostate epithelial cells. Cancer Res. 2004 Dec 15; 64(24):8867-75.
View in:
PubMed
Critical role of CDK2 for melanoma growth linked to its melanocyte-specific transcriptional regulation by MITF. Cancer Cell. 2004 Dec; 6(6):565-76.
View in:
PubMed
Molecular profiling of diffuse large B-cell lymphoma identifies robust subtypes including one characterized by host inflammatory response. Blood. 2005 Mar 01; 105(5):1851-61.
View in:
PubMed
Toward a functional taxonomy of cancer. Cancer Cell. 2004 Aug; 6(2):107-8.
View in:
PubMed
A transcriptional profiling study of CCAAT/enhancer binding protein targets identifies hepatocyte nuclear factor 3 beta as a novel tumor suppressor in lung cancer. Cancer Res. 2004 Jun 15; 64(12):4137-47.
View in:
PubMed
mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways. Nat Med. 2004 Jun; 10(6):594-601.
View in:
PubMed
Genomic approaches to hematologic malignancies. Blood. 2004 Aug 15; 104(4):923-32.
View in:
PubMed
The Six1 homeoprotein stimulates tumorigenesis by reactivation of cyclin A1. Proc Natl Acad Sci U S A. 2004 Apr 27; 101(17):6478-83.
View in:
PubMed
Metagenes and molecular pattern discovery using matrix factorization. Proc Natl Acad Sci U S A. 2004 Mar 23; 101(12):4164-9.
View in:
PubMed
Gene expression-based high-throughput screening(GE-HTS) and application to leukemia differentiation. Nat Genet. 2004 Mar; 36(3):257-63.
View in:
PubMed
MLL-rearranged leukemias: insights from gene expression profiling. Semin Hematol. 2003 Oct; 40(4):268-73.
View in:
PubMed
The molecular signature of mediastinal large B-cell lymphoma differs from that of other diffuse large B-cell lymphomas and shares features with classical Hodgkin lymphoma. Blood. 2003 Dec 01; 102(12):3871-9.
View in:
PubMed
A mechanism of cyclin D1 action encoded in the patterns of gene expression in human cancer. Cell. 2003 Aug 08; 114(3):323-34.
View in:
PubMed
PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes. Nat Genet. 2003 Jul; 34(3):267-73.
View in:
PubMed
Prostate intraepithelial neoplasia induced by prostate restricted Akt activation: the MPAKT model. Proc Natl Acad Sci U S A. 2003 Jun 24; 100(13):7841-6.
View in:
PubMed
Mining the genome for combination therapies. Nat Med. 2003 May; 9(5):510-1.
View in:
PubMed
Gene expression-based classification of malignant gliomas correlates better with survival than histological classification. Cancer Res. 2003 Apr 01; 63(7):1602-7.
View in:
PubMed
Inhibition of FLT3 in MLL. Validation of a therapeutic target identified by gene expression based classification. Cancer Cell. 2003 Feb; 3(2):173-83.
View in:
PubMed
Estimating dataset size requirements for classifying DNA microarray data. J Comput Biol. 2003; 10(2):119-42.
View in:
PubMed
The Molecular Basis of Hematologic Malignancy. Nathan DG, Oski SH, eds. Nathan and Oski’s Hematology of Infancy and Childhood. 2003; 2:1219-1258.
A molecular signature of metastasis in primary solid tumors. Nat Genet. 2003 Jan; 33(1):49-54.
View in:
PubMed
A strategy for oligonucleotide microarray probe reduction. Genome Biol. 2002; 3(12):RESEARCH0073.
View in:
PubMed
Identification of endoglin as a functional marker that defines long-term repopulating hematopoietic stem cells. Proc Natl Acad Sci U S A. 2002 Nov 26; 99(24):15468-73.
View in:
PubMed
Gamma interferon triggers interaction between ICSBP (IRF-8) and TEL, recruiting the histone deacetylase HDAC3 to the interferon-responsive element. Mol Cell Biol. 2002 Nov; 22(21):7439-48.
View in:
PubMed
Profiling gene transcription in vivo reveals adipose tissue as an immediate target of tumor necrosis factor-alpha: implications for insulin resistance. Diabetes. 2002 Nov; 51(11):3176-88.
View in:
PubMed
Abnormal gene expression in cloned mice derived from embryonic stem cell and cumulus cell nuclei. Proc Natl Acad Sci U S A. 2002 Oct 01; 99(20):12889-94.
View in:
PubMed
The immunosuppressant rapamycin mimics a starvation-like signal distinct from amino acid and glucose deprivation. Mol Cell Biol. 2002 Aug; 22(15):5575-84.
View in:
PubMed
Bcl2 regulation by the melanocyte master regulator Mitf modulates lineage survival and melanoma cell viability. Cell. 2002 Jun 14; 109(6):707-18.
View in:
PubMed
The Ewing's sarcoma oncoprotein EWS/FLI induces a p53-dependent growth arrest in primary human fibroblasts. Cancer Cell. 2002 May; 1(4):393-401.
View in:
PubMed
Tumor necrosis factor-alpha suppresses adipocyte-specific genes and activates expression of preadipocyte genes in 3T3-L1 adipocytes: nuclear factor-kappaB activation by TNF-alpha is obligatory. Diabetes. 2002 May; 51(5):1319-36.
View in:
PubMed
DNA Microarrays in Clinical Oncology. Journal of Clinical Oncology. 2002; 20(7):1932-41.
DNA microarrays in clinical oncology. J Clin Oncol. 2002 Apr 01; 20(7):1932-41.
View in:
PubMed
UBE1L is a retinoid target that triggers PML/RARalpha degradation and apoptosis in acute promyelocytic leukemia. Proc Natl Acad Sci U S A. 2002 Mar 19; 99(6):3806-11.
View in:
PubMed
Gene expression correlates of clinical prostate cancer behavior. Cancer Cell. 2002 Mar; 1(2):203-9.
View in:
PubMed
Gene expression signatures define novel oncogenic pathways in T cell acute lymphoblastic leukemia. Cancer Cell. 2002 Feb; 1(1):75-87.
View in:
PubMed
Prediction of central nervous system embryonal tumour outcome based on gene expression. Nature. 2002 Jan 24; 415(6870):436-42.
View in:
PubMed
Diffuse large B-cell lymphoma outcome prediction by gene-expression profiling and supervised machine learning. Nat Med. 2002 Jan; 8(1):68-74.
View in:
PubMed
Acute Myeloid Leukemia. Pizzo PA, Poplack DG, eds. Principles and Practice of Pediatric Oncology. 2002; 20:545-589.
Multiclass cancer diagnosis using tumor gene expression signatures. Proc Natl Acad Sci U S A. 2001 Dec 18; 98(26):15149-54.
View in:
PubMed
MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia. Nat Genet. 2002 Jan; 30(1):41-7.
View in:
PubMed
Classification of human lung carcinomas by mRNA expression profiling reveals distinct adenocarcinoma subclasses. Proc Natl Acad Sci U S A. 2001 Nov 20; 98(24):13790-5.
View in:
PubMed
Chemosensitivity prediction by transcriptional profiling. Proc Natl Acad Sci U S A. 2001 Sep 11; 98(19):10787-92.
View in:
PubMed
Genomic approaches to the pathogenesis of hematologic malignancy. Curr Opin Hematol. 2001 Jul; 8(4):252-61.
View in:
PubMed
c-Myc is a critical target for c/EBPalpha in granulopoiesis. Mol Cell Biol. 2001 Jun; 21(11):3789-806.
View in:
PubMed
Genome-wide views of cancer. N Engl J Med. 2001 Feb 22; 344(8):601-2.
View in:
PubMed
Molecular classification of multiple tumor types. Bioinformatics. 2001; 17 Suppl 1:S316-22.
View in:
PubMed
Discovering functional relationships between RNA expression and chemotherapeutic susceptibility using relevance networks. Proc Natl Acad Sci U S A. 2000 Oct 24; 97(22):12182-6.
View in:
PubMed
Genomic analysis of metastasis reveals an essential role for RhoC. Nature. 2000 Aug 03; 406(6795):532-5.
View in:
PubMed
GAP43, MARCKS, and CAP23 modulate PI(4,5)P(2) at plasmalemmal rafts, and regulate cell cortex actin dynamics through a common mechanism. J Cell Biol. 2000 Jun 26; 149(7):1455-72.
View in:
PubMed
Expression analysis with oligonucleotide microarrays reveals that MYC regulates genes involved in growth, cell cycle, signaling, and adhesion. Proc Natl Acad Sci U S A. 2000 Mar 28; 97(7):3260-5.
View in:
PubMed
Molecular Biology. Holland, James F. and Frei, Emil III, eds. Cancer Medicine. 2000; 1-16.
TEL/ETV6 Gene Rearrangements in Human Leukemias. Transcription Factors: Normal and Malignant Development of Blood Cells. 2000; 425-445.
Molecular classification of cancer: class discovery and class prediction by gene expression monitoring. Science. 1999 Oct 15; 286(5439):531-7.
View in:
PubMed
Interpreting patterns of gene expression with self-organizing maps: methods and application to hematopoietic differentiation. Proc Natl Acad Sci U S A. 1999 Mar 16; 96(6):2907-12.
View in:
PubMed
Methods and Apparatus for Analyzing Gene Expression Data. 1999.
Incidence of TEL/AML1 fusion in children with relapsed acute lymphoblastic leukemia. Blood. 1998 Dec 15; 92(12):4792-7.
View in:
PubMed
Dissecting the regulatory circuitry of a eukaryotic genome. Cell. 1998 Nov 25; 95(5):717-28.
View in:
PubMed
The TEL/ETV6 gene is required specifically for hematopoiesis in the bone marrow. Genes Dev. 1998 Aug 01; 12(15):2392-402.
View in:
PubMed
The Molecular Biology of Cancer. Nathan and Oski’s Hematology of Infancy and Childhood. 1998; 2:1092-1146.
TEL gene rearrangements in myeloid malignancy. Hematol Oncol Clin North Am. 1997 Dec; 11(6):1207-20.
View in:
PubMed
TEL is one of the targets for deletion on 12p in many cases of childhood B-lineage acute lymphoblastic leukemia. Leukemia. 1997 Aug; 11(8):1220-3.
View in:
PubMed
Yolk sac angiogenic defect and intra-embryonic apoptosis in mice lacking the Ets-related factor TEL. EMBO J. 1997 Jul 16; 16(14):4374-83.
View in:
PubMed
Occurrence of TEL-AML1 fusion resulting from (12;21) translocation in human early B-lineage leukemia cell lines. Leukemia. 1997 Mar; 11(3):441-7.
View in:
PubMed
Acute Myelogenous Leukemia. Principles and Practice of Pediatric Oncology. 1997; 463-482.
The TEL gene contributes to the pathogenesis of myeloid and lymphoid leukemias by diverse molecular genetic mechanisms. Curr Top Microbiol Immunol. 1997; 220:67-79.
View in:
PubMed
The TEL/platelet-derived growth factor beta receptor (PDGF beta R) fusion in chronic myelomonocytic leukemia is a transforming protein that self-associates and activates PDGF beta R kinase-dependent signaling pathways. Proc Natl Acad Sci U S A. 1996 Dec 10; 93(25):14845-50.
View in:
PubMed
TEL/AML-1 dimerizes and is associated with a favorable outcome in childhood acute lymphoblastic leukemia. Blood. 1996 Dec 01; 88(11):4252-8.
View in:
PubMed
p210BCR/ABL, p190BCR/ABL, and TEL/ABL activate similar signal transduction pathways in hematopoietic cell lines. Oncogene. 1996 Sep 19; 13(6):1147-52.
View in:
PubMed
The TEL gene and human leukemia. Biochim Biophys Acta. 1996 Aug 08; 1288(1):M7-10.
View in:
PubMed
Oligomerization of the ABL tyrosine kinase by the Ets protein TEL in human leukemia. Mol Cell Biol. 1996 Aug; 16(8):4107-16.
View in:
PubMed
The t(12;21) translocation converts AML-1B from an activator to a repressor of transcription. Mol Cell Biol. 1996 Apr; 16(4):1349-55.
View in:
PubMed
Mutational analysis of the candidate tumor suppressor genes TEL and KIP1 in childhood acute lymphoblastic leukemia. Cancer Res. 1996 Mar 15; 56(6):1413-7.
View in:
PubMed
Involvement of the TEL gene in hematologic malignancy by diverse molecular genetic mechanisms. Curr Top Microbiol Immunol. 1996; 211:279-88.
View in:
PubMed
TEL and KIP1 define the smallest region of deletions on 12p13 in hematopoietic malignancies. Blood. 1995 Aug 15; 86(4):1525-33.
View in:
PubMed
Fusion of the TEL gene on 12p13 to the AML1 gene on 21q22 in acute lymphoblastic leukemia. Proc Natl Acad Sci U S A. 1995 May 23; 92(11):4917-21.
View in:
PubMed
Fusion of PDGF receptor beta to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t(5;12) chromosomal translocation. Cell. 1994 Apr 22; 77(2):307-16.
View in:
PubMed
Amplification of human papillomavirus genomes in vitro is dependent on epithelial differentiation. J Virol. 1991 May; 65(5):2254-60.
View in:
PubMed
In vitro differentiation of epithelial cells from cervical neoplasias resembles in vivo lesions. Oncogene. 1990 Apr; 5(4):571-6.
View in:
PubMed
Growth and characterization of epithelial cells from normal human uterine ectocervix and endocervix. In Vitro Cell Dev Biol. 1989 Jun; 25(6):544-56.
View in:
PubMed