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Cellular Therapies Resources

  • Cellular therapies are designed to improve the immune system's ability to fight cancer. Manufacturing them involves collecting a specific set of cells from the blood, modifying them to produce a more vigorous attack on a patient's cancer cells, and then reinjecting them into the patient. Many types of cellular therapy for cancer are being explored, including CAR T cells, other genetically modified T cells, tumor infiltrating lymphocytes (TIL), vaccines, and NK cells.

    Cellular Therapies Clinical Trials

    Commercial CAR T-Cell Therapy

    CAR T-cell therapies are FDA approved for:

    • Aggressive relapsed or refractory large B-cell lymphoma including diffuse large B-cell lymphoma (DLBCL), primary mediastinal B-cell lymphoma, high-grade B-cell lymphoma, and transformed follicular lymphoma.
    • Relapsed or refractory mantle cell lymphoma
    • Relapsed or refractory follicular lymphoma
    • Relapsed or refractory multiple myeloma
    • Relapsed or refractory B-cell acute lymphoblastic leukemia (ALL)

    We also offer several CAR T-cell therapy clinical trials for several types of blood cancers and for patients at various stages of treatment.

  • Payer & Provider Collaboration: Advancing Patients through Cellular Therapy Treatment
    This webinar from June 14, 2023, provides an update on CAR T-cell therapy, with a focus on which patients may be appropriate for cellular therapy treatment. It covers the current state and future vision for cell therapies, as well as best practices for working together to ensure patients receive timely access to necessary care.

  • Key Moments

    0:03 – Welcome, Introduction
    Amy Emmert, MScPH, Executive Director for Cellular Therapy External Affairs; Kidest Mequanent, Senior Program Manager for Cell Therapies and Shared Care

    7:39 – Current State and Future Vision of Cell Therapies in Lymphoma, Leukemia, and Solid Tumors
    Caron Jacobson, MD, MMSc

    24:56 – Current State and Trends in Multiple Myeloma
    Omar Nadeem, MD

    40:52 – Financial Operations and Workflows Overview
    Pat Kelley, BSN, RN

    51:35 – Q&A

  • Referring for CAR T-Cell Therapy

    Below are guidelines we use to assess patients for CAR T-cell therapy as standard care. Additional criteria may apply for clinical trials:

    CAR T for Lymphoma

    Aggressive non-Hodgkin Lymphoma

    • Confirmed diagnosis of DLBCL, primary mediastinal large B-cell lymphoma, high-grade B-cell lymphoma, or transformed follicular lymphoma to DLBCL that has relapsed or not responded to at least two prior lines of systemic therapy, if the initial response to first-line therapy was longer than 12 months.
      • Patients with these diagnoses who do not achieve remission or relapse within 12 months of first-line therapy are eligible for CAR T as a second-line therapy.
      • Patients with DLBCL that has relapsed or not responded to first-line treatment and are not eligible for stem cell transplant are eligible for CAR T as a second-line therapy.

    Mantle Cell Lymphoma

    • Histologically confirmed diagnosis of mantle cell lymphoma that has either not responded to, or relapsed after first line of therapy.

    Follicular Lymphoma

    • Confirmed diagnosis of follicular lymphoma that has relapsed or not responded to at least two prior lines of systemic therapy.

    CAR T for Leukemia

    • Confirmed diagnosis of B-cell acute lymphoblastic leukemia (ALL) that has either not responded or has relapsed after one line of prior treatment.
    • Adequate organ, cardiac, and pulmonary function (must meet established criteria/measures).

    CAR T for Multiple Myeloma

    • Confirmed diagnosis of multiple myeloma that has relapsed or not responded (refractory) after four or more prior lines of treatment.
    • Prior therapy must have included a proteasome inhibitor, an immunomodulatory drug, and an anti-CD 38 monoclonal antibody.

    Preparing Patients for CAR T-Cell Therapy

    While CAR T-cell therapy is a promising treatment, it is also a complex, lengthy process with the risk of serious side effects. It is important that you and your patients understand:

    • Once CAR T-cell therapy is determined to be appropriate treatment, we collect the patient's T cells through leukapheresis. The T cells are then sent to a lab, either at Dana-Farber or off-site, to be engineered to express the target specific for the patient's cancer. This manufacturing process generally takes two to three weeks.
    • Patients may receive lymphodepleting chemotherapy in the days prior to their CAR T-cell infusion, to make room in their immune system for the CAR T cells to expand and proliferate.
    • Most patients are hospitalized for one to three weeks to monitor for side effects. Some patients may receive their CAR T cells in the outpatient clinic and be monitored for 14 days in the outpatient setting.
    • Potential serious side effects may include fevers, chills, low blood pressure, difficulty breathing, confusion, difficulty speaking or understanding language, or stupor. Our teams are specially trained to address these side effects, though patients may be quite ill for a period of time while in the hospital.
    • Patients must remain within two hours of Dana-Farber Brigham Cancer Center for 30 days after their CAR T-cell infusion for rapid management of side effects after discharge. A caregiver is required to stay with the patient during this period.

    Working Together

    We welcome the opportunity to discuss patients for whom CAR T-cell therapy may be appropriate. Contact us at 877-801-2278 or

    Our team works collaboratively with referring oncologists after CAR T-cell therapy. We provide guidance on what to watch for, and recommended follow-up care. To monitor the long-term effectiveness of CAR T-cell therapy, patients will require follow-up care for up to 15 years.

    More on CAR T-Cell Therapy

  • How does CAR T-cell therapy work?