ASH President and Dana-Farber's Ken Anderson, MD, Highlights Key Topics for 2017 ASH Annual Meeting
Targeted therapies and immunotherapy were among the highlights as oncology experts gathered at this year's ASH Annual Meeting. In a far-reaching Q & A, Dr. Anderson previewed exciting presentations of CAR T-cell therapy clinical trial results for
lymphoma and multiple myeloma, and a novel targeted therapy for the treatment of advanced systemic mastocytosis.
Read the full Q & A interview with ASH President Ken Anderson, MD.
Awards and Honors
- Congratulations to Benjamin Ebert, MD, PhD, Dana-Farber's Chair of Medical Oncology, who received the William Dameshek Prize, awarded to an individual no more than 50 years of age (at time of nomination) who has made outstanding contributions in hematology.
- Thank you to Kenneth Anderson, MD, Program Director of Dana-Farber's Jerome Lipper Multiple Myeloma Center, for serving as ASH President in 2017.
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View the schedule of presentations by Dana-Farber faculty.
New Findings from Dana-Farber Researchers, Presented at ASH 2017
Many Dana-Farber investigators have presented new research findings and advances at ASH 2017, including:
Study identifies agent that can reverse resistance to targeted drug in some leukemia cell types
After discovering how some hematologic cancer cells manage to elude death from a targeted therapy, Dana-Farber Cancer Institute scientists have double-crossed the cancer cells with a drug that renders them vulnerable to the targeted agent.
Study explores use of checkpoint inhibitors after relapse from donor stem cell transplant for hematologic cancers
Immunotherapy agents known as checkpoint inhibitors have shown considerable promise in patients with hematologic cancers who relapse after a transplant with donor stem cells. Preliminary results from the first clinical trial in these patients of one such
agent — nivolumab — indicate that along with signs of effectiveness, it also produced significant side effects at the dose initially studied. The findings indicate a need for further clinical trials in this group before being considered for off-label
use with these patients.
Low-dose treatment with interleukin-2 across multiple studies shows benefits in chronic graft-versus-host disease
Daily low doses of the immune signaling protein interleukin-2 (IL-2) can safely benefit patients who develop chronic graft-versus-host disease following stem cell transplants, including particular benefit in pediatric patients in one small study.
Study shows combining chemotherapy with targeted drug boosts response in chronic lymphocytic leukemia
Among younger patients newly diagnosed with chronic lymphocytic leukemia (CLL), treatment with a combination of chemotherapy and a molecularly targeted drug significantly improves response over what is typically seen with chemotherapy alone, according
to an investigator-initiated multi-center phase II clinical trial.
Sequencing offers clues to progression toward multiple myeloma
Researchers at Dana-Farber Cancer Institute have carried out the largest genomic analysis of patients with smoldering multiple myeloma (SMM), a precursor to full-blown blood cancer that doesn't show outward symptoms. The next-generation sequencing project
will help to explain the biology of the disease and how it unfolds through time from asymptomatic stages to symptomatic ones.
Tracking how multiple myeloma evolves by sequencing DNA in the blood
Although people with multiple myeloma usually respond well to treatment, the blood cancer generally keeps coming back. Following genetic changes in how the disease evolves over time will help to understand the disease and, eventually, deliver more effective
treatments. Researchers now have successfully demonstrated techniques to track these alterations over time by analyzing cell-free DNA (cfDNA) found in blood.
Rapid responses, few adverse effects seen with targeted agent in Phase 1 trial in rare blood disorder
In a Phase 1 trial, patients with an advanced or aggressive form of systemic mastocytosis (AdvSM), a rare blood disorder, had rapid and durable responses with few adverse effects following treatment with an investigational drug that targets the genetic
mutation found in more than 90 percent of cases. The once-daily pill, BLU-285, targets a mutation called KIT D816V that is found in almost all cases of AdvSM, a disease that originates in mast cells, a type of white blood cell.