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About the Inflammatory Breast Cancer Program

  • Beth Overmoyer, MD, and Filipa Lynce, MD

  • What Is Inflammatory Breast Cancer (IBC)?

    Inflammatory breast cancer is a rare and aggressive form of breast cancer in which cancer cells block the lymph vessels of the skin of the breast, causing the breast to appear red or inflamed. Unlike other types of breast cancer, a lump is usually not a symptom of IBC.


  • illustration of lymphatic drainage of the adult female breast
  • Our Unique Approach to Treating IBC

    At Dana-Farber/Brigham and Women Cancer Center's Susan F. Smith Center for Women's Cancers, we have a program dedicated to IBC treatment, research, and education. Our specialists work together, and with you, to create a personalized treatment plan tailored to your unique medical needs.

    Leading Treatment and Research for IBC

    Our specialized IBC program — the only program of its kind in the Northeast — includes breast cancer surgeons, medical oncologists, and radiation oncologists who have specific expertise in treating IBC. Our clinical team is skilled at identifying this rare and often misdiagnosed disease, ensuring that you receive the care you need as quickly as possible.

    Our physician-scientists lead research efforts that are improving the understanding of IBC and creating new treatment options. Our research scientists and clinicians meet regularly to discuss challenging cases and work together to develop studies to address these challenges. This enables us to provide a personalized approach to care for our IBC patients.

    Second Opinions for IBC

    We welcome patients diagnosed with IBC to get a second opinion with us. We can partner with your local oncologist to review your options at any stage of your treatment.

    • To make an appointment, call 877-442-3324. After scheduling, one of our nurses will call you within 24 hours to answer your questions and help you prepare for the appointment.
    • For referring physicians: To refer a patient for diagnosis and treatment for inflammatory breast cancer, call 617-632-2311 or 877-442-3324.
    • For more information about the Inflammatory Breast Cancer Program, call 617-632-2311.

  • Inflammatory Breast Cancer Program Overview
    Filipa Lynce, MD, director of the Inflammatory Breast Cancer (IBC) Program provides an overview of IBC and our approach to caring for patients.


  • Diagnosis and Treatment of IBC

    Signs and symptoms of inflammatory breast cancer may include:

    • Redness of the breast
    • Breast swelling or enlargement
    • Pain or itchiness of the breast
    • Thickening of the skin on the breast and ridged or dimpled skin texture (peau d'orange)
    • Swelling of the lymph nodes in your armpit or above/below the collarbone
    illustration of IBC symptoms

    Risk factors of inflammatory breast cancer include:

    • Being a woman: Women are more likely to be diagnosed with IBC than men — but men can develop IBC, too.
    • Being younger than 60: Patients with IBC are on average diagnosed at a younger age compared to patients with other forms of breast cancer.
    • Being a person of color: Persons of color are more at risk of developing inflammatory breast cancer than white persons.
    • Being overweight/obese: Overweight or obese persons have a greater risk of developing IBC, regardless of their menopausal status.
    How is IBC different from mastitis?

    IBC shares some outward similarities to mastitis and can be misdiagnosed at first. Mastitis sometimes involves a bacterial infection that is treated with antibiotics. IBC is not an infection and does not respond to antibiotics. If you are diagnosed with mastitis but don't respond to antibiotic treatment within a week, you should ask your doctor about testing for inflammatory breast cancer.

    How is IBC diagnosed?

    If you experience any of the symptoms above, contact your physician immediately. IBC is typically diagnosed through a clinical exam and confirmed with a breast biopsy. We can help coordinate your breast imaging and a clinical evaluation, which may include a biopsy. Prompt and accurate diagnosis and treatment are important because of the aggressive nature of the disease.

    If you have not been diagnosed yet, our IBC specialists at Dana-Farber/Brigham and Women's Cancer Center will work quickly to determine whether your symptoms are IBC or something else (such as a breast infection). If a diagnosis of IBC is determined, your dedicated team of IBC clinicians will work together to create and oversee a personalized treatment plan, based on your specific disease.

    What are the next steps after IBC is diagnosed?

    Once a diagnosis of IBC is confirmed, we will schedule your appointment with a dedicated team, which can include medical, surgical, and radiation oncologists, as soon as possible. Our multidisciplinary team reviews all diagnostic imaging and coordinates further imaging or biopsies as needed, to ensure that the best information is available for treatment planning.

    What are the treatments for inflammatory breast cancer?
    • Chemotherapy: Because IBC involves the entire breast and blood stream, the primary treatment is chemotherapy, sometimes in combination with other medications. This may include a clinical trial.
    • Mastectomy: Once we have achieved the best response possible from chemotherapy, we often recommend surgery in the form of a mastectomy. Since IBC involves the lymphatic system — special blood channels that encompass the entire breast — a mastectomy is the only way to remove the cancer in the breast and lymph nodes under the arm (axilla).
    • Radiation therapy: Radiation therapy is used following surgery to address any residual cancer left behind in the skin or lymph nodes.
    • Additional treatments after surgery: Sometimes additional chemotherapy, hormone therapy, or other medications are recommended after surgery.
    • Treatment for IBC that has spread to other parts of the body: If your IBC has spread to other parts of the body, such as bone, liver, or lungs (known as metastatic cancer), your treatment will require chemotherapy or other drugs that work throughout the body, as well as on the IBC in the breast. Mastectomy and radiation therapy may not be needed but can be beneficial for some women with metastatic IBC. Our specialists will work with you to develop a treatment plan based on your specific disease, as well as your goals and values.
    What are my options for reconstructive surgery?

    While women with other forms of breast cancer may opt for breast reconstruction immediately following a mastectomy, we recommend that IBC patients considering reconstruction delay the procedure. Many patients may safely choose to have reconstruction approximately 6 months to one year after completing radiation.

    What support services are available?

    IBC nurses and staff will connect you with support services both at Dana-Farber and in your community. Through this coordinated approach, your entire clinical team will work with you, not only to treat your IBC, but also to provide support every step of the way.

    IBC specialists coordinate your care with pharmacy, nutrition services, social workers, pain management specialists, and many other support services, to ensure that you feel as well as possible throughout your treatment.


  • Dana-Farber Inflammatory Breast Cancer Program: Celebrating 10 Years of Progress and Innovation
    Beth Overmoyer, MD, and Filipa Lynce, MD, along with their colleagues and patients, celebrate the advances in research, treatment, and support in the decade since the IBC Program was founded.


  • Next: Learn about our inflammatory breast cancer specialists
  • New Patient Appointments
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  • Inflammatory Breast Cancer Program's 10-Year Celebration and Educational Virtual Forum

    On Saturday, April 24, 2021, the Inflammatory Breast Cancer Program held a virtual forum celebrating and providing patient-care-focused scientific information in the field of inflammatory breast cancer to researchers, physicians, nurses, and patients.

    View 2021 IBC Forum Recordings

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