News tagged ‘Genomics’ clear
- Hospitals are using DNA sequencing to generate better treatments and diagnoses for patients, including Dana-Farber, which offers adult patients a test for almost 500 gene variations. Dr. Barrett Rollins say cancer is among the most promising targets because it is essentially a disease in which damaged genes let cells grow without restraint.
- Dr. Pasi Jänne and colleagues found that more than half of lung and colon cancer patients may benefit from high-speed tests that detect DNA flaws doctors can target with existing medicines.
Tags: ColonCancer, Genomics, LungCancer
- Dr. Andrea Richardson and colleagues have identified a genetic marker that may predict which aggressive "triple negative" breast cancers and certain ovarian cancers will likely respond to platinum-based chemotherapies.
Tags: BreastCancer, Genomics, OvarianCancer, GynecologicCancers
- Epigenetics was the subject of a particularly interesting session, held on April 1st, at a meeting of the American Association for Cancer Research in Chicago. James Bradner, MD, described how his group has shown that a substance known as JQ1, which inhibits an epigenetic regulator called BRD4, blocks the activity of a gene by the name of Myc.
- Dana-Farber researchers were part of The Cancer Genome Atlas study that identified four genetically distinct types of breast cancer, each with its own biology and survival outlooks. Matthew Meyerson, MD, PhD, one of the study's co-authors, said the findings could help direct the development of better treatments, adding that it likely will result in new combination therapies rather than one "silver bullet" drug.
Tags: BreastCancer, Genomics
- Judy Garber, MD, MPH, discussed the potential clinical implications of the findings from a study from The Cancer Genome Atlas that identified four genetically distinct types of breast cancer.
Tags: BreastCancer, Genomics
- Dr. Bruce E. Johnson said researchers at Foundation Medicine in Cambridge, Mass., have been routinely testing for certain "alterations" in cancer cells to help target treatments and new technologies.
Tags: Genomics, TargetedTherapy
- Cambridge-based Foundation Medicine is bringing high-tech tools to the battle against cancer. Founded in 2009 by leaders in genome technology including Dana-Farber, the company is analyzing patients' tumors for the entire coding sequence of 200-plus genes known to be altered in human cancers.
- The National Cancer Institute reported successes in the effort to overhaul the publicly funded clinical trials system. Dr. Levi Garraway pointed to the extraordinary possibilities and challenges of designing cutting-edge trials using genomic profiling.
- Dr. John Quackenbush discusses the collaboration of GenoSpace and the Multiple Myeloma Research Foundation to advance cancer research and development. GenoSpace provides tools for genomics research.
Tags: Genomics, MultipleMyeloma