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Dana-Farber Cancer Institute, Novartis and Harvard team up to develop next generation biomaterial systems to deliver immunotherapies

  • Collaboration and licensing agreement combine expertise in tumor biology and materials science
  • Teams will explore the development of novel implantable and injectable biomaterial systems
  • Investigators at Dana-Farber and Harvard’s Wyss Institute have reported evidence of anti-cancer immunity in preclinical experiments of the biomaterial systems.

 

Scientists from Dana-Farber Cancer Institute and Wyss Institute for Biologically Inspired Engineering at Harvard University are teaming up to develop biomaterial systems for Novartis’ portfolio of immuno-oncology therapies.

The licensed biomaterial systems aim to overcome barriers that have hampered traditional cancer vaccines, including their limited duration of action and lack of targeting to specific cancer cells. Through many years’ work, researchers at Dana-Farber and the Harvard John A. Paulson School of Engineering and Applied Sciences (SEAS), and the Wyss Institute have engineered the biomaterial systems with an aim to provide sustained delivery of immunotherapies and target specific types of cancer. Novartis will further collaborate with the team at the Wyss Institute to advance development of the biomaterial systems, investigating their use to deliver agents from its broad and deep portfolio of second-generation immunotherapies.

“This effort has been a tremendous translation of biomedical engineering to cancer therapeutics. It allows an individualized approach to cancer vaccines as well as a novel method to manipulate what we know about the immune system to educate it against cancer, said Stephen Hodi, MD, Director, Center for Immuno-Oncology at Dana-Farber Cancer Institute and Primary Investigator of the Phase 1 trial.

“Our collaborators have combined the fields of immuno-oncology and material science to develop novel platforms for delivering immunotherapies to combat cancer,” said Jay Bradner, President of the Novartis Institutes for BioMedical Research (NIBR). “We look forward to collaborating with the Wyss Institute to further develop this technology in conjunction with our growing immunotherapy portfolio.”

The licensing agreement with Harvard’s Office of Technology Development and the collaboration with the Wyss Institute support Novartis’ efforts to develop combination immunotherapy regimens.  New immunotherapies have benefited subsets of cancer patients, presenting opportunities to develop new immuno-oncology treatment strategies to help more patients. Novartis is developing combination immunotherapies in clinical trials.

The implantable and injectable systems are made of biodegradable materials that assemble into porous, three-dimensional structures. In lab experiments, the systems release cell-recruiting factors to attract host dendritic cells and present tumor antigens to those specialized immune cells, intending to bolster immune responses to cancer. While these systems have yet not been proven in human clinical trials, they hold great promise because of their potential to serve as engineered microenvironments to educate the immune system about cancer and initiate immune responses against tumors over a sustained period of time.

The technologies licensed under this agreement for target-specific applications are owned or co-owned by Harvard University, Dana-Farber, and the University of Michigan.

 

 

Posted on March 20, 2018

  • F. Stephen Hodi, MD
  • Immunotherapy

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Made of the polymer that’s used in biodegradable sutures, this aspirin-sized device is designed to deliver immunotherapy agents that activate the immune system against tumors. Image courtesy of the Wyss Institute at Harvard University