Prophylactic Antibiotic Regimens in Tumor Surgery (PARITY)

Status: Recruiting
Phase: Phase 3
Diagnosis: Sarcoma
NCT ID: NCT01479283 (View complete trial on
DFCI Protocol ID: 13-222


The Prophylactic Antibiotic Regimens in Tumor Surgery (PARITY) trial is the first ever international multi-center randomized controlled trial in bone cancer surgery. In order to avoid amputation for bone cancer in the leg, complex limb-saving operations are performed. However, infections with devastating complications following surgery are common. Surgeons from across the world will randomize patients to receive either short- or long-duration antibiotic regimens after surgery with the goal of identifying the best regimen to reduce these infections.


Conducting Institutions:
Beth-Israel Deaconess Medical Center, Children's Hospital Boston, Massachusetts General Hospital

Overall PI:
Megan Anderson, MD, Beth Israel Deaconess Medical Center

Site-responsible Investigators:

Beth-Israel Deaconess Medical Center: Cancer Trials Call Center, 617-667-3060

Eligibility Criteria

Inclusion Criteria: - primary malignant or aggressive benign bone tumors of the lower extremity - treated by surgical excision and endoprosthetic replacement Exclusion Criteria: - current known Methicillin-resistant Staphylococcus Aureus (MRSA)colonization - current known Vancomycin Resistant Enterococcus (VRE)colonization - documented anaphylaxis or angioedema to penicillin or cefazolin (Ancef) - prior surgery within the surgical field of the affected limb - prior local infection within the surgical field of the affected limb - current known immunologically-deficient disease conditions (not including recent chemotherapy) - known renal insufficiency with estimated creatinine clearance (eGRF) of less than 54 mL/min - reconstruction to include allograft - enrolled in a competing study
  • Email
  • Print
  • Share
  • Text
Highlight Glossary Terms
  • Make an Appointment

    • For adults:
      877-442-3324 (877-442-DFCI)

    • Quick access:
      Appointments as soon as the next day for new adult patients

    • For children:
      888-733-4662 (888-PEDI-ONC)

    • Request Appointment Online