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Status: RecruitingPhase: Phase 1/Phase 2Diagnosis: Cutaneous Skin CancerNCT ID: NCT01989585
(View complete trial on ClinicalTrials.gov)
DFCI Protocol ID: 13-424
This partially randomized phase I/II trial studies the side effects and best dose of dabrafenib, trametinib, and navitoclax and to see how well they work in treating patients with v-raf murine sarcoma viral oncogene homolog B (BRAF) mutant melanoma or solid tumors that have spread to other parts of the body or cannot be removed by surgery. Dabrafenib, trametinib, and navitoclax may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.
Conducting Institutions: Massachusetts General Hospital, Dana-Farber Cancer Institute
Overall PI: Ryan Sullivan, MD,
Beth Israel Deaconess Medical Center
Contacts: Massachusetts General Hospital:
Cancer Trials Call Center, 877-789-6100